Bilirubin adsorber and bilirubin concentration detection method

Abstract

The invention provides a bilirubin adsorber and a bilirubin concentration detection method, the bilirubin adsorber comprises an adsorber main body and a bilirubin detector, the adsorber main body is provided with a limiting groove, and the bilirubin detector is arranged in the limiting groove; a transparent detection window is arranged in an area, corresponding to the limiting groove, of the adsorber main body, so that the bilirubin detector detects the concentration of bilirubin in plasma in the adsorber main body through the detection window. The bilirubin adsorber can accurately detect the concentration of bilirubin, and medical staff can accurately determine the saturation degree of the bilirubin adsorber conveniently.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a bilirubin adsorber and a method for detecting bilirubin concentration. Background Art

[0002] Blood bilirubin adsorption is to separate the plasma from the blood to be adsorbed, and then pass the plasma to be adsorbed through a bilirubin adsorber for specific adsorption, so as to adsorb and remove the bilirubin in the plasma to be adsorbed, and significantly reduce the bilirubin concentration in the blood to be adsorbed.

[0003] Existing bilirubin adsorbers are usually disposable consumables, and the usage time is generally 120 minutes to 180 minutes. In clinical blood purification, medical staff usually confirm the saturation level of the bilirubin adsorber based on the instructions or previous experience. Medical staff cannot accurately determine the saturation time of the bilirubin adsorber, so the bilirubin adsorber ends blood purification before reaching the saturation level, resulting in waste of adsorption materials in the bilirubin adsorber, or the bilirubin adsorber continues to adsorb after reaching saturation, increasing the risk of blood purification. In addition, the prior art usually requires blood drawing to detect bilirubin concentration after blood purification to determine whether blood purification needs to be performed again, but it generally takes a period of time to obtain the blood test results, which reduces the efficiency of bilirubin adsorption. Summary of the invention

[0004] The present invention aims to solve the above-mentioned defects of the prior art and provides a bilirubin adsorber and a method for detecting bilirubin concentration to accurately detect the concentration of bilirubin, so as to facilitate medical staff to accurately determine the saturation degree of the bilirubin adsorber.

[0005] In order to solve the above problems, the first aspect of the present invention provides a bilirubin adsorber, comprising:

[0006] An adsorber body, wherein a limiting groove is provided on the adsorber body;

[0007] A bilirubin detector, wherein the bilirubin detector is arranged in the limiting groove;

[0008] The area on the adsorber body corresponding to the limiting groove has a transparent detection window, so that the bilirubin detector can detect the bilirubin concentration of the plasma inside the adsorber body through the detection window.

[0009] Further, the adsorber body comprises a column and two end-sealing pieces, the column is hollow inside, the two end-sealing pieces are used to seal the two ends of the column along the first direction, at least one end of the column is provided with the detection window, and the detection window has a groove;

[0010] The limiting groove is provided on at least one of the end sealing members, and one end of the limiting groove along the first direction passes through the end sealing member and is connected with the groove.

[0011] Furthermore, the end sealing member includes an end cap and an opaque locking nut, the end cap is used to seal the end of the column along the first direction, the end cap is connected to the column through the locking nut, and the limiting groove is arranged on the locking nut.

[0012] Furthermore, the bilirubin detector includes a detector body and a detection head, the detection head protrudes from the detector body along a second direction and extends to the inside of the groove, a reflective optical sensor is arranged inside the detection head, and the second direction is perpendicular to the first direction.

[0013] Furthermore, the outer peripheral wall of the column is provided with an outwardly protruding limiting ring, the limiting ring is arranged close to the detection window, one end of the detector body abuts against the limiting ring, and the other end of the detector body abuts against the locking nut;

[0014] The end sealing member is provided with a clamping protrusion, the clamping protrusion abuts against an end of the detection head away from the limiting ring, and the clamping protrusion extends to the inside of the groove.

[0015] Furthermore, the detector body comprises a shell, on which a display screen is arranged. The display screen is arranged on one end of the shell away from the detection head along the second direction, and the display screen is used to display the bilirubin concentration of the plasma inside the adsorber body.

[0016] A second aspect of the present invention provides a method for detecting bilirubin concentration, comprising:

[0017] Detecting real-time bilirubin concentration using the bilirubin adsorber described in the first aspect;

[0018] According to the bilirubin concentrations detected at multiple moments, it is determined whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0019] Further, judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes:

[0020] According to the bilirubin concentrations detected at multiple moments, a curve showing the change of bilirubin concentration over time is fitted;

[0021] When the slope of the curve is not greater than a first preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0022] Further, judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes:

[0023] Determining the standard deviation of the bilirubin concentration according to the bilirubin concentrations detected at multiple moments;

[0024] When the standard deviation is not greater than a second preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0025] Furthermore, the real-time bilirubin concentration is detected by the bilirubin adsorber, comprising:

[0026] Detecting the real-time bilirubin concentration at the plasma inlet and the real-time bilirubin concentration at the plasma outlet by means of the bilirubin adsorber;

[0027] The step of judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes:

[0028] Determine the concentration difference between the plasma inlet and the plasma outlet at the same time according to the bilirubin concentration at the plasma inlet and the bilirubin concentration at the plasma outlet at any one of the multiple time points detected;

[0029] When the concentration difference is not greater than a third preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0030] The bilirubin adsorber described in the present invention has a bilirubin detector arranged on the adsorber body. The bilirubin detector can detect the bilirubin concentration of the plasma inside the adsorber body through a transparent detection window, so that medical staff can timely understand the clearance of bilirubin, and the medical staff can infer the saturation of bilirubin in the adsorber body according to the change of bilirubin concentration, thereby realizing accurate detection of the saturation of bilirubin in the adsorber body, which not only avoids the uncertainty based on experience judgment, but also avoids the need to draw blood to detect bilirubin concentration after blood purification, which is conducive to improving the convenience of use for medical staff and improving the use efficiency of the bilirubin adsorber.

[0031] The method for detecting bilirubin concentration of the present invention can detect the real-time bilirubin concentration through a bilirubin adsorber, and according to the bilirubin concentrations at multiple moments detected, it can be timely determined whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, thereby achieving accurate detection of the saturation of bilirubin in the adsorber body, which not only avoids the uncertainty based on empirical judgment, but also avoids blood drawing to detect bilirubin concentration after blood purification, making it convenient for medical staff to quickly determine whether blood purification is needed again, which not only improves the convenience of use for medical staff, but also improves the use efficiency of the bilirubin adsorber. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 A schematic diagram of the main structure of a bilirubin adsorber provided in an embodiment of the present invention;

[0033] Figure 2 A schematic diagram of a partial structure of a bilirubin adsorber provided by an embodiment of the present invention without a bilirubin detector;

[0034] Figure 3 for Figure 2 A schematic cross-sectional structure diagram of ;

[0035] Figure 4 for Figure 1 Schematic diagram of the cross-sectional structure along the AA plane;

[0036] Figure 5 for Figure 4 Schematic diagram of the local structure;

[0037] Figure 6 A schematic diagram of the three-dimensional structure of a bilirubin detector provided in an embodiment of the present invention;

[0038] Figure 7 A schematic diagram of the main structure of a bilirubin detector provided in an embodiment of the present invention;

[0039] Figure 8 A flow chart for detecting bilirubin concentration provided by an embodiment of the present invention;

[0040] Fig. 9 A curve showing the change of bilirubin concentration over time provided by an embodiment of the present invention;

[0041] Fig.10 Another curve of bilirubin concentration changing with time provided by an embodiment of the present invention;

[0042] Fig.11 This is a working schematic diagram of the bilirubin adsorber provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0043] The technical solution of the present invention is described clearly and in detail below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate the orientation or position relationship based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In addition, in the description of the present invention, the meaning of "at least one" is one or more, unless otherwise clearly and specifically defined.

[0044] In the description of this specification, the term "as an optional implementation" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one optional embodiment or optional example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same implementation or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0045] Combination Figure 1 and Figure 3 As shown, the first aspect of this embodiment provides a bilirubin adsorber, comprising: an adsorber body 10 and a bilirubin detector 20, the adsorber body 10 is provided with a limiting groove 30, and the bilirubin detector 20 is arranged in the limiting groove 30, wherein:

[0046] The area on the adsorber body 10 corresponding to the limiting groove 30 has a transparent detection window 111 , so that the bilirubin detector 20 detects the bilirubin concentration of the plasma inside the adsorber body 10 through the detection window 111 .

[0047] The bilirubin adsorber provided in this embodiment has a bilirubin detector arranged on the adsorber body. The bilirubin detector can detect the bilirubin concentration of the plasma inside the adsorber body through a transparent detection window, so that medical staff can timely understand the clearance of bilirubin, and the medical staff can infer the saturation of bilirubin in the adsorber body according to the change of bilirubin concentration, thereby realizing accurate detection of the saturation of bilirubin in the adsorber body, which not only avoids the uncertainty based on experience judgment, but also avoids the need to draw blood to detect bilirubin concentration after blood purification, which is conducive to improving the convenience of use for medical staff and improving the use efficiency of the bilirubin adsorber.

[0048] Based on the above embodiment, as an optional implementation mode, Figure 2 and Figure 3 As shown, the adsorber body 10 includes a column 11 and two end-capping members 12. The column 11 has openings at both ends along the axial direction (i.e., the first direction). The column 11 is hollow inside. The end-capping members 12 are used to seal the openings of the column 11. The two end-capping members 12 are respectively installed at the two openings of the column 11 along the axial direction. A detection window 111 is provided at at least one end of the column 11. The detection window 111 has a groove that is recessed toward the inside of the column 11. The groove can be an arc-shaped groove. A limiting groove 30 is provided on at least one end-capping member 12. One end of the limiting groove 30 along the first direction passes through the end-capping member 12 and is connected to the groove. Therefore, by providing a groove on the column 11, and one end of the limiting groove 30 passes through the end-capping member 12 and is connected to the groove, the distance between the bilirubin detector 20 and the detection window 111 can be reduced, which is conducive to further improving the accuracy of the bilirubin detector 20 in detecting the bilirubin concentration of the plasma inside the adsorber body 10.

[0049] Based on the above embodiment, as an optional implementation mode, Figures 4 to 5 As shown, the end cap 12 includes an end cap 121 and a locking nut 122. The end cap 121 is used to seal the opening of the column 11, and the end cap 121 is connected to the column 11 through the locking nut 122. Specifically, the locking nut 122 is threadedly connected to the outer peripheral wall of the column 11, so that the end cap 121 is fixedly connected to the column 11 through the locking nut 122. The limiting groove 30 is set on the locking nut 122, and the locking nut 122 is an opaque locking nut. Therefore, by setting the limiting groove 30 on the locking nut 122, it is possible to avoid affecting the sealing performance of the end cap 12, thereby not affecting the adsorption performance and safety performance of the adsorber body 10. In addition, the opaque locking nut 122 can play a light shielding role when the bilirubin detector 20 detects, so that the light cannot penetrate the locking nut 122, so that the light can only be received by the bilirubin detector 20, which is conducive to improving the accuracy of the bilirubin detector 20 in detecting the bilirubin concentration.

[0050] On the basis of the above embodiment, as an optional implementation, the end cap 12 further includes a cap 123, a grid 124 and a sealing ring 125. The end cap 121 is provided with a blood nozzle 1211 and a cover body 1212 protruding from the column 11 in the axial direction. The cover body 1212 is arranged around the blood nozzle 211. The cover body 1212 and the blood nozzle 211 are integrally formed, and the blood nozzle 1211 is connected to the inner space of the ring of the cover body 1212. The cover body 1212 extends into the inner cavity of the column 11. The cover body 1212 is provided with a blood nozzle 1211 and a cover body 1212 protruding from the column 11 in the axial direction. Part of the outer peripheral wall surface of 12 contacts part of the inner tube wall surface of the column 11, wherein the grid 124 is arranged between the cover body 1212 and the end of the column 11, and a filter is arranged on the grid 124, and the filter covers the end opening of the column 11, and the sealing ring 125 is arranged in the space enclosed by the outer peripheral wall surface of the cover body 1212, the grid 124 and the inner tube wall surface of the column 11 to ensure the sealing performance of the end sealing member 12, and the cap 123 is used to cover the blood nozzle 1211 to achieve the sealing of the blood nozzle 1211.

[0051] Based on the above embodiment, as an optional implementation mode, Figure 6 and Figure 7As shown, the bilirubin detector 20 includes a detector body and a detection head 21 arranged on the detector body, the detection head 21 protrudes from the detector body along the radial direction (i.e., the second direction), the detector body is located in the limiting groove 30, the detection head 21 extends to the inside of the groove, the detection head 21 can contact the detection window 111, and a reflective optical sensor is arranged inside the detection head 21. The reflective optical sensor detects the bilirubin concentration by a light reflection method. The reflective optical sensor has a light source and a light receiving device. The light source is used to emit light to the inside of the column 11, and the light receiving device is used to receive the reflected light inside the column 11, and the light wave density difference is converted to obtain the bilirubin concentration of the plasma inside the adsorber body 10. As an optional embodiment, the light source emits white light (wavelength of 430nm to 490nm) to illuminate the plasma in the column 11, and the bilirubin in the plasma absorbs part of the light, but the bilirubin cannot absorb blue light (wavelength of 450nm or 460nm) and green light (wavelength of 550nm), and the locking nut 122 is opaque, which can play a light shielding role, and the light cannot pass through the locking nut 122, so that the blue light and green light that are not absorbed by the bilirubin in the plasma are reflected to the light receiving device for reception, and the density difference between the two wavelengths of blue light and green light and the bilirubin concentration conform to the Lambert-Beer law, and the bilirubin concentration is obtained by converting the density difference between the two wavelengths of blue light and green light. Therefore, by setting a reflective optical sensor inside the detection head 21, non-contact measurement of bilirubin concentration can be achieved, and the bilirubin concentration is calculated based on the density difference between the two wavelengths of light waves, which is more accurate than judging the bilirubin concentration based on experience. In this embodiment, the specific type of the light receiving device in the reflective optical sensor is not further limited, and those skilled in the art can select a common light receiving device in the prior art according to actual conditions. Based on the above embodiment, as an optional implementation, the light source of the detection head 21 can continuously emit white light, or the light source of the detection head 21 can intermittently emit white light, and if it is intermittent emission, the interval time is 1 minute to 5 minutes.

[0052] On the basis of the above embodiment, as an optional implementation, the detector body includes a shell 22, the detection head 21 protrudes from the shell 22, a processor and a memory are arranged inside the shell 22, the processor is electrically connected to the memory and the detection head 21 through a bus, the memory stores program instructions that can be executed by the processor, and the processor calls the program instructions to execute the bilirubin concentration detection method as described in the second aspect. In addition, the reflective optical sensor can transmit the density difference between the two wavelengths of blue light and green light detected by it to the processor, and the processor can calculate the bilirubin concentration according to the density difference between the two wavelengths of light waves.

[0053] On the basis of the above embodiment, as an optional implementation, the detector body also includes a display screen 23, which is arranged on the shell 22. The display screen 23 is arranged on one end of the shell 22 away from the detection head 21 in the radial direction. The display screen 23 is used to display the bilirubin concentration of the plasma inside the adsorber body 10. The display screen 23 is electrically connected to the processor. After the processor calculates the bilirubin concentration based on the density difference between the two wavelengths of light waves, the processor transmits the bilirubin concentration to the display screen 23 for display, so that medical staff can view it in real time.

[0054] On the basis of the above embodiment, as an optional implementation, the end face of the shell 22 provided with the display screen 23 is flush with the outer peripheral wall of the end sealing member 12, or the end face of the shell 22 provided with the display screen 23 protrudes from the outer peripheral wall of the end sealing member 12. If the end face of the shell 22 provided with the display screen 23 protrudes from the outer peripheral wall of the end sealing member 12, the distance between the end face of the shell 22 provided with the display screen 23 and the outer peripheral wall of the end sealing member 12 is less than or equal to 5 mm, that is, the end face of the shell 22 provided with the display screen 23 does not protrude from the outer peripheral wall of the locking nut 122, and the distance between the end face of the shell 22 provided with the display screen 23 and the outer peripheral wall of the locking nut 122 is less than or equal to 5 mm. In this way, the outer surface of the bilirubin detector 20 can be made roughly flush with the outer peripheral wall of the end sealing member 12, avoiding increasing the size and floor space of the bilirubin adsorber, and also facilitating packaging and transportation.

[0055] On the basis of the above embodiment, as an optional implementation, the detector body also includes a wireless transmission module and a battery module, both of which are arranged inside the housing 22, and the wireless transmission module is electrically connected to the processor. The processor can transmit the bilirubin concentration to a mobile terminal such as a mobile phone or a computer through the wireless transmission module, so that the mobile terminal such as a mobile phone or a computer can receive the bilirubin concentration, which is convenient for medical staff to understand and view the bilirubin concentration in real time, so as to timely replace the saturated adsorber body 10, or timely understand the patient's blood purification situation, and quickly determine whether it is necessary to continue blood purification on site. The battery module is electrically connected to the detection head 21, the processor, the display screen 23 and the wireless transmission module, respectively, and the battery module supplies power to the detection head 21, the processor, the display screen 23 and the wireless transmission module. The wireless transmission module and the battery module in this embodiment can both adopt common structures in the prior art. For example, the wireless transmission module can be a 4G chip, a 5G chip, a WiFi module or a Bluetooth module, and the battery module can include a lithium battery.

[0056] Based on the above embodiment, as an optional implementation, a switch 24 is further provided on the housing 22, the switch 24 and the display screen 23 are provided on the same end surface of the housing 22, a switch circuit electrically connected to the battery module is provided inside the switch 24, and the switch 24 is used to control the opening or closing of the bilirubin detector 20. The switch circuit in this embodiment can adopt a common structure in the prior art, and those skilled in the art can select it according to actual conditions.

[0057] On the basis of the above embodiment, as an optional implementation, the bilirubin detector 20 is detachably arranged in the limiting groove 30. Specifically, the outer peripheral wall of the column 11 is provided with an outwardly convex limiting ring 112, and the limiting ring 112 is arranged close to the detection window 111. One end of the detector body along the axial direction abuts against the limiting ring, and the other end of the detector body along the axial direction abuts against the locking nut 122 in the end cap 12, so that the bilirubin detector 20 is clamped in the limiting groove 30. Therefore, the limiting ring 122 can play a role in supporting the detector body, and the limiting ring 122 and the locking nut 122 cooperate to enable the bilirubin detector 20 to be clamped in the limiting groove 30. As another optional implementation, a sliding groove can also be provided on the locking nut 122, and a slider that cooperates with the sliding groove can be provided on the detector body, so that the bilirubin detector 20 can be detachably arranged in the limiting groove 30. The bilirubin detector in this embodiment is detachably arranged on the adsorber body through the limiting groove, so that the adsorber body can be used once, and the bilirubin detector is reusable, which can detect the concentration of bilirubin and reduce the use cost of the bilirubin adsorber. Of course, the bilirubin detector 20 in this embodiment can also be fixedly arranged in the limiting groove 30, so that the bilirubin detector 20 is fixedly arranged on the adsorber body 10. Exemplarily, the bilirubin detector 20 can be fixedly connected to the limiting groove 30 by bonding. Preferably, the bilirubin detector 20 is detachably arranged in the limiting groove 30, so that the bilirubin detector can be reused, which is beneficial to reduce the use cost of the bilirubin adsorber.

[0058] On the basis of the above embodiment, as an optional implementation, a cam 1221 is provided on the locking nut 122, and the cam 1221 abuts against the end of the detection head 21 away from the limiting ring 112, and the cam 1221 extends to the inside of the groove. Therefore, when the bilirubin detector 20 is inserted into the limiting groove 30, the detection head 21 is inserted into the inside of the groove, and the cam 1221 can be inserted into the gap between the detection head 21 and the groove, so that the bilirubin detector 20 can be more firmly clamped in the limiting groove 30, improving the stability of the assembly of the bilirubin detector 20, and also helping to improve the accuracy and stability of the assembly between the locking nut 122 and the column 11. As an optional implementation, the cam 1221 can be a flexible cam, and illustratively, the cam 1221 can be a cam made of silicone material.

[0059] On the basis of the above embodiment, as an optional implementation, the locking nuts 122 of the two end-sealing members 12 are both provided with a limiting groove 30, and a bilirubin detector 20 is detachably provided in each limiting groove 30. Therefore, by providing the bilirubin detector 20 on both end-sealing members 12, the bilirubin concentration at the plasma inlet end and the bilirubin concentration at the plasma outlet end of the adsorber body 10 can be detected respectively, so that the concentration change of bilirubin can be judged more timely and accurately, and the saturation of bilirubin in the adsorber body can be detected more accurately.

[0060] Based on the above embodiment, as an optional implementation, the locking nuts of the two end-sealing pieces 12 are of different colors to distinguish the plasma inlet and plasma outlet of the adsorber body 10, thereby avoiding misjudgment of the concentration change of bilirubin. Exemplarily, the locking nut of one end-sealing piece 12 is red, and the locking nut of the other end-sealing piece 12 is blue.

[0061] In this embodiment, the column 11 can be a transparent column 11, and the interior of the column 11 is used to load an adsorbent and a preservation solution. The adsorbent can be a material having the function of adsorbing bilirubin, such as a styrene-based anion exchange resin, cellulose, agarose, etc. The preservation solution can be physiological saline or water for injection. The column 11, the end cap 121, the locking nut 122, the cap 123 and other structures are made of PC or PP materials.

[0062] Figure 8 The flowchart of detecting bilirubin concentration provided in the embodiment of the present invention. Figure 8 As shown, the second aspect of the present invention provides a method for detecting bilirubin concentration, comprising:

[0063] Detecting the real-time bilirubin concentration by the bilirubin adsorber of the first aspect;

[0064] According to the bilirubin concentrations detected at multiple moments, it is determined whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0065] The method for detecting bilirubin concentration provided in this embodiment can detect the real-time bilirubin concentration through a bilirubin adsorber. According to the bilirubin concentrations at multiple moments detected, it can be timely determined whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, thereby achieving accurate detection of the saturation of bilirubin in the adsorber body. This not only avoids the uncertainty based on empirical judgment, but also avoids blood drawing to detect bilirubin concentration after blood purification, making it convenient for medical staff to quickly determine whether blood purification is needed again, which not only improves the convenience of use for medical staff, but also improves the use efficiency of the bilirubin adsorber.

[0066] In this embodiment, a bilirubin detector 20 can be detachably provided on the adsorber body 10. The bilirubin detector 20 is provided on the locking nut 122 at the plasma inlet end of the adsorber body 10, or the bilirubin detector 20 is provided on the locking nut 122 at the plasma outlet end of the adsorber body 10. By detecting the bilirubin concentration at the plasma inlet end or detecting the bilirubin concentration at the plasma outlet end through the bilirubin adsorber, it is possible to accurately determine whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, and to reduce the use cost of the bilirubin adsorber.

[0067] Combination Fig.11 As shown, during the process of the bilirubin adsorber adsorbing bilirubin in the plasma, the plasma circulates, so when a bilirubin detector 20 is provided on the adsorber body 10, the bilirubin detector 20 can be provided on the locking nut 122 at the plasma inlet end of the adsorber body 10, or the bilirubin detector 20 can be provided on the locking nut 122 at the plasma outlet end of the adsorber body 10. Preferably, the bilirubin detector 20 is provided on the locking nut 122 at the plasma outlet end of the adsorber body 10, so that the concentration of bilirubin in the plasma after adsorption by the adsorber body 10 can be more accurately detected.

[0068] Based on the above embodiment, as an optional implementation, if a bilirubin detector 20 is detachably provided on the adsorber body 10, judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes:

[0069] According to the bilirubin concentrations detected at multiple moments, a curve showing the change of bilirubin concentration over time is fitted;

[0070] When the slope of the curve is not greater than the first preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0071] Specifically, the detection head of the bilirubin detector 20 continuously emits white light, and the bilirubin concentration at the plasma inlet or the bilirubin concentration at the plasma outlet at multiple moments is continuously detected. Each moment is used as the horizontal coordinate, and the bilirubin concentration at the plasma inlet or the bilirubin concentration at the plasma outlet corresponding to each moment is used as the vertical coordinate. The curve of the bilirubin concentration changing with time is fitted, and the slope of the curve is calculated in real time. When the slope of the curve is not greater than the first preset threshold value, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0072] Fig. 9 It is a curve of bilirubin concentration changing with time, where the vertical axis unit is μmol / L and the horizontal axis unit is minute. Fig. 9As shown, the inclination of the curve gradually decreases and finally tends to be gentle, that is, the absolute value of the slope of the curve gradually decreases until the slope of the curve is no greater than the first preset threshold value, which also shows that the adsorption capacity of the bilirubin adsorber for bilirubin is gradually weakened until the concentration of bilirubin adsorbed by the bilirubin adsorber reaches saturation. Among them, the first preset threshold value is K, then -0.05<K≤0.

[0073] In this embodiment, by fitting a curve of bilirubin concentration changing with time and judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation by the slope of the curve, the concentration of bilirubin adsorbed by the bilirubin adsorber can be continuously detected, thereby being able to more accurately determine the time when the bilirubin adsorber reaches saturation.

[0074] Based on the above embodiment, as another optional implementation, if a bilirubin detector 20 is detachably provided on the adsorber body 10, then judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes:

[0075] Determining the standard deviation of the bilirubin concentration according to the bilirubin concentrations detected at multiple moments;

[0076] When the standard deviation is not greater than the first preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0077] Specifically, the detection head 21 of the bilirubin detector 20 emits white light intermittently, detects the bilirubin concentration at the plasma inlet end or the bilirubin concentration at the plasma outlet end at least three times, calculates the standard deviation of the bilirubin concentration at least three times, and when the standard deviation is not greater than the second preset value threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, wherein the interval between any two adjacent moments in at least three moments is 1 minute to 5 minutes. Therefore, when the standard deviation is not greater than the second preset threshold, it means that the bilirubin concentration at at least three moments detected by the bilirubin detector 20 changes little, and the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0078] In this embodiment, the second preset threshold is less than or equal to 1.0 μmol / L. Setting the second preset threshold within this range can more accurately determine whether the bilirubin adsorber has reached saturation.

[0079] In this embodiment, by determining the standard deviation of the bilirubin concentration and judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation through the standard deviation, the concentration of bilirubin adsorbed by the bilirubin adsorber can be intermittently detected, thereby improving the efficiency of determining the saturation time of the bilirubin adsorber.

[0080] In this embodiment, two bilirubin detectors 20 can be detachably arranged on the adsorber body 10, and the two bilirubin detectors 20 are respectively arranged on the locking nut 122 at the plasma inlet end of the adsorber body 10 and the locking nut 122 at the plasma outlet end of the adsorber body 10. By detecting the bilirubin concentration at the plasma inlet end and the bilirubin concentration at the plasma outlet end through the bilirubin adsorber, the difference between the bilirubin concentration at the plasma inlet end and the bilirubin concentration at the plasma outlet end can be directly confirmed, which is convenient for medical staff to promptly and accurately judge whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, which is beneficial to improving the detection efficiency.

[0081] Based on the above embodiment, as an optional implementation, if two bilirubin detectors 20 are detachably provided on the adsorber body 10, the real-time bilirubin concentration is detected by the bilirubin adsorber, including:

[0082] The real-time bilirubin concentration at the plasma inlet and the real-time bilirubin concentration at the plasma outlet are detected by a bilirubin adsorber;

[0083] According to the bilirubin concentrations detected at multiple moments, it is judged whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, including:

[0084] Determine the concentration difference between the plasma inlet and the plasma outlet at the same time according to the bilirubin concentration at the plasma inlet and the bilirubin concentration at the plasma outlet at any one of the multiple time points detected;

[0085] When the concentration difference is not greater than the third preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0086] Specifically, the bilirubin detector 20 arranged on the locking nut 122 at the plasma inlet end of the adsorber body 10 detects the bilirubin concentration of the plasma inlet end at multiple moments, and the bilirubin detector 20 arranged on the locking nut 122 at the plasma outlet end of the adsorber body 10 detects the bilirubin concentration of the plasma outlet end at multiple moments. A moment among the multiple moments is arbitrarily selected, and the concentration difference between the bilirubin concentration at the plasma inlet end at that moment and the bilirubin concentration at the plasma outlet end at that moment is calculated. When the concentration difference is not greater than the third preset threshold value, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0087] In this embodiment, the third preset threshold is less than or equal to 1.0 μmol / L. Setting the third preset threshold within this range can more accurately determine whether the bilirubin adsorber has reached saturation.

[0088] In this embodiment, by determining the concentration difference between the bilirubin concentration at the plasma inlet and the bilirubin concentration at the plasma outlet at the same time, and judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation through the concentration difference, it is possible to timely and accurately judge whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, and it is beneficial to improve the detection efficiency.

[0089] Based on the above embodiment, as another optional implementation, if two bilirubin detectors 20 are detachably provided on the adsorber body 10, the real-time bilirubin concentration is detected by the bilirubin adsorber, including:

[0090] The real-time bilirubin concentration at the plasma inlet and the real-time bilirubin concentration at the plasma outlet are detected by a bilirubin adsorber;

[0091] According to the bilirubin concentrations detected at multiple moments, it is judged whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, including:

[0092] According to the bilirubin concentrations at multiple moments detected, respectively fitting a first curve of the bilirubin concentration at the plasma inlet end changing with time and a second curve of the bilirubin concentration at the plasma outlet end changing with time;

[0093] When the slope of the first curve and / or the second curve is not greater than the first preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0094] Fig.10 Another curve showing the change of bilirubin concentration over time, where the vertical axis is in μmol / L and the horizontal axis is in minutes. Fig.10As shown, the change trends of the first curve and the second curve are similar, the inclination of the two curves gradually decreases, and finally tends to be gentle, and as time goes by, the two curves approach or intersect, indicating that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation. Although it can also be judged whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation by whether the first curve and the second curve approach or intersect, in actual use, due to the influence of the sensitivity of the two bilirubin detectors or the plasma components, the concentration of bilirubin detected by the two bilirubin detectors has a certain error, which may cause the bilirubin adsorber to reach saturation, but the first curve and the second curve do not intersect, or the first curve and the second curve both tend to be gentle, but the difference between the two is large, which may cause judgment errors and affect the accuracy of detection. Therefore, in this embodiment, in order to improve the accuracy of detection, it can only be judged whether the slope of at least one of the two curves is not greater than the first preset threshold value to determine whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation. In order to improve the convenience of detection, those skilled in the art may only judge whether the slope of the first curve or the second curve is not greater than the first preset threshold value to determine whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

[0095] Based on the above embodiment, as an optional implementation, the method for detecting bilirubin concentration further includes:

[0096] After determining that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation, the bilirubin adsorber issues an alarm prompt. The alarm prompt can be a sound alarm prompt or a light source alarm prompt to prompt medical staff that the adsorber body 10 is saturated with adsorption, so that medical staff can replace the adsorber body 10 in time, or end blood purification. The bilirubin adsorber or bilirubin detector can also include a sound alarm module and / or a light source alarm module. If the bilirubin concentration value of any one of the plasma inlet end or the plasma outlet end is still higher than the normal value after the adsorber body 10 is adsorbed saturated, the medical staff can replace the adsorber body 10 to continue blood purification; if the bilirubin concentration value of the plasma inlet end is not higher than the normal value after the adsorber body 10 is adsorbed saturated, the medical staff can end blood purification. Therefore, by issuing an alarm prompt through the bilirubin adsorber, it is convenient for medical staff to understand in time that the bilirubin adsorber has reached a saturated state, and it is convenient for medical staff to quickly determine whether blood purification is needed again, thereby improving the feasibility of precision medicine.

[0097] Based on the above embodiment, as an optional implementation, the method for detecting bilirubin concentration further includes:

[0098] The real-time bilirubin concentration detected by the bilirubin adsorber is transmitted to the mobile terminal through the wireless transmission module, and the real-time bilirubin concentration detected by the bilirubin adsorber is stored in the memory to generate a record report. Thus, by transmitting the bilirubin concentration to a mobile terminal such as a mobile phone or a computer through the wireless transmission module, it is convenient for medical staff to observe the concentration change of bilirubin, and it can be more intuitive to judge whether the bilirubin adsorber has reached a saturated state, and when the bilirubin adsorber has reached a saturated state, the mobile terminal can receive an alarm prompt issued by the bilirubin adsorber, so that the medical staff can end the blood purification in time or replace the bilirubin adsorber to perform blood purification again, so as to avoid the medical staff missing the alarm prompt. By storing the real-time bilirubin concentration detected by the bilirubin adsorber in the memory, a record report is generated, which is convenient for medical staff to view and analyze later.

[0099] The bilirubin detector in this embodiment detects the bilirubin concentration of the plasma inside the adsorber body 10 through the detection window 111 in the following manner:

[0100] The bilirubin detector emits white light through the detection window 111 and receives reflected blue light and green light, and calculates the bilirubin concentration based on the density difference between the two wavelengths of blue light and green light received. The density difference between the two wavelengths of blue light and green light and the bilirubin concentration conform to the Lambert-Beer law.

[0101] Specifically, the detection head 21 of the bilirubin detector 20 emits white light (wavelength of 430nm to 490nm) through the detection window 111, and the white light is irradiated to the plasma in the column 11 through the detection window 111. The bilirubin in the plasma absorbs part of the light, but the bilirubin cannot absorb blue light (wavelength of 450nm or 460nm) and green light (wavelength of 550nm), and the locking nut 122 is opaque and can play a light-shielding role. The light cannot pass through the locking nut 122, so that the blue light and green light that are not absorbed by the bilirubin in the plasma are reflected to the detection head 21 and received by the light receiving device inside the detection head 21. The density difference between the two wavelengths of blue light and green light and the bilirubin concentration conform to the Lambert-Beer law. The bilirubin concentration is obtained by converting the density difference between the two wavelengths of blue light and green light.

[0102] The bilirubin adsorber of this embodiment includes a memory and a processor. The memory stores program instructions that can be executed by the processor. The processor calls the program instructions to execute the above-mentioned method for detecting bilirubin concentration.

[0103] The processor may be a CPU (Central Processing Unit), a general-purpose processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field Programmable Gate Array) or other programmable logic devices, transistor logic devices, hardware components or any combination thereof. It may implement or execute various exemplary logic blocks, modules and circuits described in conjunction with the disclosure of this application. The processor may also be a combination that implements computing functions, exemplarily including a combination of one or more microprocessors, a combination of a DSP and a microprocessor, etc.

[0104] The bus may include a path to transmit information between the above components. The bus may be a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus, etc. The bus may be divided into an address bus, a data bus, a control bus, etc.

[0105] The memory can be ROM (Read Only Memory) or other types of static storage devices that can store static information and instructions, RAM (Random Access Memory) or other types of dynamic storage devices that can store information and instructions, or it can be EEPROM (Electrically Erasable Programmable Read Only Memory), CD-ROM (Compact Disc Read Only Memory) or other optical disk storage, optical disk storage (including compressed optical disk, laser disk, optical disk, digital versatile disk, Blu-ray disk, etc.), magnetic disk storage medium or other magnetic storage device, or any other medium that can be used to carry or store the desired program code in the form of instructions or data structures and can be accessed by a computer, but is not limited to this.

[0106] The memory is used to store the application code for executing the solution of the present application, and the execution is controlled by the processor. The processor is used to execute the application code stored in the memory to implement the content shown in the above method embodiment.

[0107] Although the disclosure is disclosed as above, the protection scope of the disclosure is not limited thereto. Those skilled in the art may make various changes and modifications without departing from the spirit and scope of the disclosure, and these changes and modifications will fall within the protection scope of the present invention.

Claims

1. A bilirubin adsorber, characterized in that: include: An adsorber body, wherein a limiting groove is provided on the adsorber body; A bilirubin detector, wherein the bilirubin detector is arranged in the limiting groove; The area on the adsorber body corresponding to the limiting groove has a transparent detection window, so that the bilirubin detector can detect the bilirubin concentration of the plasma inside the adsorber body through the detection window.

2. The bilirubin adsorber according to claim 1, characterized in that: The adsorber body comprises a column and two end-sealing pieces, the column is hollow inside, the two end-sealing pieces are used to seal the two ends of the column along the first direction, at least one end of the column is provided with the detection window, and the detection window has a groove; The limiting groove is provided on at least one of the end sealing members, and one end of the limiting groove along the first direction passes through the end sealing member and is connected with the groove.

3. The bilirubin adsorber according to claim 2, characterized in that: The end sealing member includes an end cap and an opaque locking nut, wherein the end cap is used to seal the end of the column barrel along the first direction, the end cap is connected to the column barrel through the locking nut, and the limiting groove is arranged on the locking nut.

4. The bilirubin adsorber according to claim 3, characterized in that: The bilirubin detector includes a detector body and a detection head, wherein the detection head protrudes from the detector body along a second direction and extends to the inside of the groove, a reflective optical sensor is arranged inside the detection head, and the second direction is perpendicular to the first direction.

5. The bilirubin adsorber according to claim 4, characterized in that: The outer peripheral wall of the column is provided with an outwardly protruding limiting ring, the limiting ring is arranged close to the detection window, one end of the detector body abuts against the limiting ring, and the other end of the detector body abuts against the locking nut; The end sealing member is provided with a clamping protrusion, the clamping protrusion abuts against an end of the detection head away from the limiting ring, and the clamping protrusion extends to the inside of the groove.

6. The bilirubin adsorber according to claim 5, characterized in that: The detector body comprises a shell, on which a display screen is arranged. The display screen is arranged at one end of the shell away from the detection head along the second direction, and is used to display the bilirubin concentration of the plasma inside the adsorber body.

7. A method for detecting bilirubin concentration, characterized in that: include: Detecting real-time bilirubin concentration by the bilirubin adsorber according to any one of claims 1 to 6; According to the bilirubin concentrations detected at multiple moments, it is determined whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

8. The detection method according to claim 7, characterized in that: The step of judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes: According to the bilirubin concentrations detected at multiple moments, a curve showing the change of bilirubin concentration over time is fitted; When the slope of the curve is not greater than a first preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

9. The detection method according to claim 7, characterized in that: The step of judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes: Determining the standard deviation of the bilirubin concentration according to the bilirubin concentrations detected at multiple moments; When the standard deviation is not greater than a second preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

10. The detection method according to claim 7, characterized in that: The real-time bilirubin concentration is detected by the bilirubin adsorber, including: Detecting the real-time bilirubin concentration at the plasma inlet and the real-time bilirubin concentration at the plasma outlet by means of the bilirubin adsorber; The step of judging whether the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation according to the bilirubin concentrations detected at multiple moments includes: Determine the concentration difference between the plasma inlet and the plasma outlet at the same time according to the bilirubin concentration at the plasma inlet and the bilirubin concentration at the plasma outlet at any one of the multiple time points detected; When the concentration difference is not greater than a third preset threshold, it is determined that the concentration of bilirubin adsorbed by the bilirubin adsorber has reached saturation.

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