Non-invasive nerve regulation and control device, control method and electronic equipment

Abstract

The invention relates to the technical field of medical instruments, in particular to a non-invasive nerve regulation device which comprises a central controller, an acquisition module, a monitoring module, a data processing module and a display module, the acquisition module, the monitoring module, the data processing module and the display module are in communication connection with the central controller, and the acquisition module comprises at least one wearable flexible ultrasonic transducer in communication connection with the central controller. A signal transmitting end of the wearable flexible ultrasonic transducer is in direct contact with the skin of a part, to be subjected to nerve regulation, of a user; the central controller is used for controlling the working state of the wearable flexible ultrasonic transducer; the monitoring module comprises an echo signal receiver arranged corresponding to the ultrasonic transducer, and the echo signal receiver is used for receiving an echo signal which is transmitted and reflected by the ultrasonic waves in the body tissue of the part to be subjected to nerve regulation and control; the data processing module is used for generating an ultrasonic image according to the echo signal; the display module is used for displaying the ultrasonic image. The comfort of a patient in the nerve regulation and control treatment process can be improved, and meanwhile treatment errors are reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a non-invasive nerve regulation device, a control method and an electronic device. Background Art

[0002] Existing technologies usually use neuromodulation to treat epilepsy patients. Neuromodulation refers to a treatment mode that uses electrical or chemical methods to change the function and state of the nervous system to obtain an effective treatment mode. Existing neuromodulation methods mainly include two approaches: electrical stimulation and ultrasonic regulation. Electrical stimulation technology achieves regulation by directly transmitting electrical signals to the nervous system. Its advantage is that it can achieve fast and precise control of neural activity. However, traditional electrical stimulation methods require the implantation of electrodes to achieve regulation by directly transmitting electrical signals to the nervous system. This method not only places high demands on the quality and durability of the electrodes, but also, due to the invasiveness of surgical implantation, it will cause inevitable damage to organ tissues, increase the risk of infection and other complications, and the electrode stability will also decrease over time, so the long-term stability is poor. Patient acceptance is low, and the complexity and recovery period of the operation are long.

[0003] In contrast, ultrasound control technology uses its mechanical or thermal effects to activate or inhibit neuronal activity. It is non-invasive and has high spatial resolution. It is harmless to the organism and can achieve long-term acquisition of neural signals. However, existing ultrasound control technology also has shortcomings. It requires preoperative target area positioning and delineation. During positioning, the patient's position and different body shapes will affect the delineation results, and thus affect the accuracy of ultrasound stimulation of surrounding organs. Existing ultrasound control technology usually requires B-ultrasound positioning and target area delineation during implementation. However, due to the differences in individual patients, and the patient's position for B-ultrasound positioning cannot be completely consistent with the position during neuromodulation treatment, treatment errors are prone to occur. Summary of the invention

[0004] In order to improve the patient's comfort during neuromodulation treatment and reduce treatment errors, a non-invasive neuromodulation device, control method and electronic equipment are provided.

[0005] In order to achieve the above-mentioned purpose of the present invention, the present invention provides a non-invasive neuromodulatory device.

[0006] A non-invasive nerve regulation device provided by the present invention includes a central controller, and a collection module, a monitoring module, a data processing module and a display module connected to the central controller in communication.

[0007] The acquisition module includes at least one wearable flexible ultrasonic transducer that is communicatively connected to the central controller, and the signal transmitting end of the wearable flexible ultrasonic transducer is in direct contact with the skin of the user's part to be nerve regulated;

[0008] The central controller is used to control the working state of the wearable flexible ultrasonic transducer, and the wearable flexible ultrasonic transducer emits an ultrasonic signal after being turned on;

[0009] The monitoring module includes an echo signal receiver arranged corresponding to the ultrasonic transducer, and the echo signal receiver is used to receive the echo signal transmitted and reflected by the body tissue of the part to be nerve regulated by the ultrasonic wave;

[0010] The data processing module is used to generate an ultrasonic image according to the echo signal;

[0011] The display module is used to display ultrasound images.

[0012] Optionally, the wearable flexible ultrasonic transducer comprises a piezoelectric layer, an electrode layer and a flexible substrate which are stacked in sequence, and a signal receiving end of the echo signal receiver is arranged in contact with the piezoelectric layer;

[0013] The electrode layer is connected to the central controller for communication, and the electrode layer is connected to the power supply, and the electrode layer is used to apply voltage or receive electrical signals;

[0014] The piezoelectric layer is used to convert electrical signals into ultrasonic waves or convert ultrasonic waves into electrical signals.

[0015] Optionally, the material of the piezoelectric layer is polyvinylidene fluoride or piezoelectric ceramics, and the material of the flexible substrate is polyimide or polydimethylsiloxane; the area of ​​the piezoelectric layer is greater than or equal to the area of ​​the electrode layer, and the area of ​​the flexible substrate is greater than the area of ​​the piezoelectric layer.

[0016] Optionally, the step of the data processing module generating an ultrasound image according to the received echo signal includes:

[0017] Preprocessing the echo signal to obtain a preprocessed echo signal;

[0018] Synthesize the pre-processed echo signals of multiple channels into one beam;

[0019] The beamformed signal is scan-converted to convert the beamformed signal into an ultrasonic image.

[0020] Optionally, before performing scan conversion on the beamformed signal and converting the beamformed signal into an ultrasonic image, the method further includes:

[0021] The dynamic range of the echo signal is compressed to a preset reference interval to obtain a dynamically compressed beam signal; the data processing module generates an ultrasound image based on the dynamically compressed beam signal

[0022] Optionally, after the data processing module scans and converts the beamformed signal into an ultrasonic image, it further includes: performing enhancement processing on the ultrasonic image to obtain an enhanced ultrasonic image, and sending the enhanced ultrasonic image to the display module; the step of enhancing the ultrasonic image includes:

[0023] The ultrasonic image is decomposed and reconstructed by wavelet transform to obtain an enhanced ultrasonic image;

[0024] Alternatively, the ultrasound image is enhanced and denoised using deep learning technology to obtain an enhanced ultrasound image.

[0025] Optionally, an input module is also included that is communicatively connected to the central controller, and the input module is used to receive ultrasonic output parameters of the wearable flexible ultrasonic transducer. The ultrasonic output parameters include ultrasonic intensity, frequency, irradiation time and waveform of the output ultrasonic wave.

[0026] Optionally, it also includes a signal generator and a power amplifier that are communicatively connected to the central controller, the signal input end of the signal generator is connected to the central processor, the signal output end of the signal generator is connected to the signal input end of the power amplifier, and the signal output end of the power amplifier is connected to the signal input end of the flexible ultrasonic transducer;

[0027] The signal generator is used to generate a first electrical signal based on the ultrasound output parameter;

[0028] The power amplifier is used to amplify and impedance match the first electrical signal to obtain a second electrical signal;

[0029] The flexible ultrasonic transducer generates ultrasonic waves based on the second electrical signal.

[0030] In order to solve the above problems, the present invention also provides a non-invasive nerve regulation device control method for controlling the above non-invasive nerve regulation device, the method comprising:

[0031] Monitoring the start signal, generating a first start instruction when the start signal is detected and sending the first start instruction to the wearable flexible ultrasonic transducer to control the wearable flexible ultrasonic transducer to emit a first ultrasonic signal;

[0032] Monitor the echo signal transmitted and reflected by ultrasound in the body tissue at the site to be nerve modulated;

[0033] generating an ultrasound image according to the echo signal;

[0034] determining ultrasonic output parameter information of the wearable flexible ultrasonic transducer according to the echo signal and the ultrasonic image;

[0035] A second start instruction is generated based on the ultrasonic output parameter information and sent to the flexible ultrasonic transducer to control the flexible ultrasonic transducer to emit a second ultrasonic signal.

[0036] In order to solve the above problem, the present invention further provides an electronic device, the electronic device comprising:

[0037] at least one processor; and,

[0038] a memory communicatively connected to the at least one processor; wherein,

[0039] The memory stores a computer program that can be executed by the at least one processor, and the computer program is executed by the at least one processor so that the at least one processor can execute the non-invasive neuromodulation device control method described above.

[0040] In summary, this application includes the following beneficial technical effects:

[0041] The wearable flexible ultrasonic transducer has high mechanical flexibility and stretchability. It can fit the human skin, avoiding the tissue damage caused by traditional electrical stimulation and optical fiber implantation, and improving the patient's comfort during the neuromodulation treatment process. When using it, first fix the wearable flexible ultrasonic transducer on the patient's body so that the signal transmitting end of the wearable flexible ultrasonic transducer fits tightly with the patient's skin, and then turn on the non-invasive neuromodulation device. The central controller controls the wearable flexible ultrasonic transducer to emit ultrasonic signals, and the echo signal receiver can receive the ultrasonic waves in the body. The echo signal transmitted and reflected by the tissue is transmitted back to the central controller, and the data processing module can generate an ultrasonic image based on the echo signal. Medical staff can display the ultrasonic image through the display module to observe the specific conditions of the body tissues where the wearable flexible ultrasonic transducer is fixed, and fine-tune the pasting position of the wearable flexible ultrasonic transducer, so that the wearable flexible ultrasonic transducer can be accurately and stably attached to the surface position of the target organ for nerve regulation. When adjusting the position of the wearable flexible ultrasonic transducer, the user's body position does not need to change, thereby avoiding unstable regulation effect caused by position offset. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 A schematic diagram of a module of a non-invasive neuromodulation device provided by an embodiment of the present invention;

[0043] Figure 2 A schematic diagram of the structure of a non-invasive neuromodulatory device provided by an embodiment of the present invention;

[0044] Figure 3 A physical picture of a wearable flexible ultrasonic transducer provided in one embodiment of the present invention;

[0045] Figure 4 A waveform diagram of an echo signal and an ultrasonic image generated based on the echo signal provided by an embodiment of the present invention;

[0046] Figure 5 A schematic diagram showing the control principle of a wearable flexible ultrasonic transducer by an input module provided in one embodiment of the present invention;

[0047] Figure 6 A flow chart of a non-invasive nerve regulation device control method provided by an embodiment of the present invention;

[0048] Figure 7 A schematic diagram of a module of an electronic device provided by an embodiment of the present invention.

[0049] Figure numerals: 10, processor; 11, memory; 12, communication bus; 13, communication interface; 2, central controller; 3, acquisition module; 31, wearable flexible ultrasonic transducer; 4, monitoring module; 41, echo signal receiver; 5, data processing module; 6, display module; 7, input module; 8, signal generator; 9, power amplifier.

[0050] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0051] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0052] In the description of the present invention, it is necessary to understand that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0053] In the description of the present invention, unless otherwise specified and limited, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a mechanical connection or an electrical connection, or it can be the internal connection between two components. It can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances.

[0054] Reference Figure 1 and Figure 2 A non-invasive nerve regulation device of the present invention includes a central controller 2, and a collection module 3, a monitoring module 4, a data processing module 5 and a display module 6 which are connected to the central controller 2 in communication.

[0055] The acquisition module 3 includes at least one wearable flexible ultrasonic transducer 31 that is communicatively connected to the central controller 2, and the signal transmitting end of the wearable flexible ultrasonic transducer 31 is in direct contact with the skin of the user's nerve regulation part; the central controller 2 can control the working state of the wearable flexible ultrasonic transducer 31, and the wearable flexible ultrasonic transducer 31 emits an ultrasonic signal after being turned on;

[0056] Reference Figure 1 and Figure 2 The monitoring module 4 includes an echo signal receiver 41 arranged corresponding to the ultrasonic transducer, and the echo signal receiver 41 is used to receive the echo signal transmitted and reflected by the body tissue of the part to be nerve regulated; the data processing module 5 can generate an ultrasonic image according to the echo signal, and the display module 6 can display the ultrasonic image.

[0057] When in use, the wearable flexible ultrasonic transducer 31 is first fixed on the patient's body so that the signal emitting end of the wearable flexible ultrasonic transducer 31 is in close contact with the patient's skin; in this embodiment, the wearable flexible ultrasonic transducer 31 can be directly placed on the patient's skin, or the wearable flexible ultrasonic transducer 31 can be attached to the patient's body using medical tape, or the wearable flexible ultrasonic transducer 31 can be fixed to the patient's body with the help of gel, or the signal emitting end of the wearable flexible ultrasonic transducer 31 can be attached to the patient's skin in any way, which is not limited in this embodiment.

[0058] After the wearable flexible ultrasonic transducer 31 is fixed, the non-invasive nerve regulation device is turned on, the central controller 2 controls the wearable flexible ultrasonic transducer 31 to emit an ultrasonic signal, the echo signal receiver 41 can receive the echo signal transmitted and reflected by the ultrasonic wave in the body tissue and transmit it back to the central controller 2, the data processing module 5 can generate an ultrasonic image according to the echo signal, and use the reflection characteristics of ultrasonic waves in different tissues to obtain the ultrasonic image of the organ, and the medical staff can display the ultrasonic image through the display module 6 to observe the specific conditions of the body tissue where the wearable flexible ultrasonic transducer 31 is fixed, and fine-tune the pasting position of the wearable flexible ultrasonic transducer 31; the combination of the echo signal receiver 41 and the wearable flexible ultrasonic transducer 31 can make the wearable flexible ultrasonic transducer 31 accurately and stably attached to the surface position of the target organ of nerve regulation, avoiding the instability of the regulation effect caused by position offset.

[0059] Reference Figure 2 and Figure 3 The wearable flexible ultrasonic transducer 31 includes a piezoelectric layer, an electrode layer and a flexible substrate which are stacked in sequence, and the signal receiving end of the echo signal receiver 41 is bonded to the piezoelectric layer;

[0060] The electrode layer is communicatively connected to the central controller 2, and the electrode layer is connected to the power supply. The electrode layer includes an upper electrode and a lower electrode, and is usually made of metal or a conductive polymer. The electrode layer is used to apply voltage or receive electrical signals. The material of the piezoelectric layer is polyvinylidene fluoride or piezoelectric ceramics, and the piezoelectric layer is used to convert electrical signals into ultrasonic waves or convert ultrasonic waves into transmitted electrical signals. Specifically, in the process of controlling the wearable flexible ultrasonic transducer 31 to emit ultrasonic waves, the central controller 2 applies voltage through the electrode layer, and the piezoelectric material in the piezoelectric layer will generate mechanical vibrations. The generated mechanical vibrations are transmitted to the surrounding medium through the flexible substrate to form ultrasonic waves. When the echo signal generated after the ultrasonic wave is reflected by the human tissue acts on the piezoelectric layer, it will cause mechanical vibrations of the piezoelectric material. The mechanical vibrations are converted into recovered electrical signals through the piezoelectric effect, and the electrode layer sends the recovered electrical signals to the central controller 2. The central controller 2 analyzes and processes the recovered electrical signals.

[0061] The area of ​​the piezoelectric layer is greater than or equal to the area of ​​the electrode layer, the area of ​​the flexible substrate is greater than the area of ​​the piezoelectric layer, and the material of the flexible substrate is made of flexible materials such as polyimide or polydimethylsiloxane, so that the wearable flexible ultrasonic transducer 31 has high mechanical flexibility and stretchability, so that the wearable flexible ultrasonic transducer 31 can fit the human skin, provide a comfortable wearing experience, realize non-invasive neural regulation, and avoid the tissue damage problems caused by traditional electrical stimulation and optical fiber implantation.

[0062] The steps of the data processing module 5 generating an ultrasonic image according to the received echo signal include:

[0063] S31. Preprocess the echo signal to obtain a preprocessed echo signal.

[0064] The steps of preprocessing the echo signal include filtering, denoising and gain compensation of the echo signal; first, a low-pass filter is used to remove high-frequency noise and retain useful signal components; then the noise in the signal is further reduced through the wavelet denoising algorithm, and finally time gain compensation or distance-amplitude compensation is performed to adjust the amplitude of the signal to compensate for the attenuation of the signal during the propagation process.

[0065] S32. Synthesize the pre-processed echo signals of multiple channels into a beam.

[0066] Specifically, the delay summation algorithm is used to delay the echo signals of multiple channels so that the signals at the same point are added in phase, thereby synthesizing a clearer image. In the preferred mode of this embodiment, during the beamforming process, the echo signals of multiple channels are windowed in the spatial domain, that is, the echo signals are matched filtered to improve the signal-to-noise ratio of the echo signals.

[0067] S33: Scan the beamformed signal to convert it into an ultrasonic image.

[0068] Specifically, the polar coordinate data of the beamformed signal (ultrasonic signal) is converted into a rectangular coordinate image suitable for display on the display module 6 through a coordinate transformation algorithm.

[0069] Before performing scan conversion on the beamformed signal and converting the beamformed signal into an ultrasonic image, the data processing module 5 further performs the following processing on the beamformed signal:

[0070] The dynamic range of the echo signal is compressed to a preset reference interval to obtain a dynamically compressed beam signal; the dynamic range of the ultrasonic echo signal is compressed to a range that can be displayed by the display so as to more completely display the image details; in this embodiment, the dynamic range of the beamformed signal can be compressed from a larger value (such as 0 to 2047) to a smaller value (such as 0 to 255) through mathematical transformation, so that the ultrasonic image generated by the data processing module 5 based on the dynamically compressed beam signal can be displayed more clearly on the display module 6.

[0071] In order to facilitate the understanding of those skilled in the art, Figure 4 Taking the process of neural regulation of the spleen as an example, the waveform diagram of the echo signal and the ultrasound image generated based on the echo signal are displayed; among them, Figure 4 (a) is the spleen ultrasound echo signal monitored by the echo signal receiver 41, Figure 4 (b) is the beamformed signal synthesized based on the spleen ultrasound echo signal. Figure 4 (c) Schematic diagram of the spleen ultrasound image generated by the synthesized beamformed signal.

[0072] After performing scan conversion on the beamformed signal and converting the beamformed signal into an ultrasonic image, the data processing module 5 further includes:

[0073] S34 , performing enhancement processing on the ultrasonic image to obtain an enhanced ultrasonic image, and sending the enhanced ultrasonic image to the display module 6 .

[0074] The steps of enhancing the ultrasound image include:

[0075] The ultrasonic image is decomposed and reconstructed by wavelet transform to obtain an enhanced ultrasonic image, thereby effectively removing the noise of the ultrasonic image and enhancing the details of the ultrasonic image.

[0076] Alternatively, deep learning techniques (such as convolutional neural networks, autoencoders, or generative adversarial networks, etc.) are used to enhance and denoise the ultrasonic image to obtain an enhanced ultrasonic image, thereby improving the clarity of the ultrasonic image finally displayed on the display module 6.

[0077] The non-invasive neuroregulatory device also includes an input module 7 that is communicatively connected to the central controller 2. The input module 7 is used to receive ultrasonic output parameters of the wearable flexible ultrasonic transducer 31. The input module 7 can obtain the ultrasonic output parameters through an input unit, such as receiving resolution information through keyboard input, touch screen input or audio input; the input module 7 can also obtain the ultrasonic output parameters through a communication unit, such as through wired communication such as a control line, or by receiving wireless signals to receive ultrasonic output parameters; the ultrasonic output parameters include the ultrasonic intensity, frequency, irradiation time and waveform of the output ultrasonic wave.

[0078] Reference Figure 5 The non-invasive nerve regulation device also includes a signal generator 8 and a power amplifier 9 which are communicatively connected to the central controller 2, the signal input end of the signal generator 8 is connected to the central processor, the signal output end of the signal generator 8 is connected to the signal input end of the power amplifier 9, and the signal output end of the power amplifier 9 is connected to the signal input end of the flexible ultrasonic transducer;

[0079] The signal generator 8 is used to generate a first electrical signal based on the ultrasonic output parameter; the power amplifier 9 is used to amplify and impedance match the first electrical signal to obtain a second electrical signal; and the flexible ultrasonic transducer generates ultrasonic waves based on the second electrical signal.

[0080] In the preferred implementation of this embodiment, the central controller 2 realizes precise control of the ultrasound intensity, frequency and irradiation time through a program control module, and can be adjusted according to different experimental requirements, with high flexibility and applicability.

[0081] Medical staff can adjust the ultrasonic output parameters of the wearable flexible ultrasonic transducer 31 according to the actual usage scenario. For example, before performing neuromodulation on the patient, the ultrasonic output parameters of the wearable flexible ultrasonic transducer 31 are set to an ultrasonic intensity not higher than 2W / cm 2 (Watts per square centimeter), the ultrasonic frequency range is 1-5kHz, and the ultrasonic wave is output in pulse wave mode. The signal generator 8 generates a first electrical signal according to the initially set ultrasonic output parameters to drive the wearable flexible ultrasonic transducer 31 to operate.

[0082] Afterwards, the central controller 2 determines the depth of the target organ to be neuroregulated and the ultrasonic image of the target organ according to the received echo signal, so that the medical staff can adjust the ultrasonic output parameters to the ultrasonic parameters required for neuroregulation according to the specific position of the patient's organ to be neuroregulated, and record the ultrasonic parameters required for neuroregulation as the target ultrasonic output parameters. In the subsequent neuroregulation process, the central controller 2 determines the signal strength of the second electrical signal according to the target ultrasonic output parameters, and drives the signal generator 8 to send out the second electrical signal. The second electrical signal is processed by the power amplifier 9 and sent to the wearable flexible ultrasonic transducer 31 to control the wearable flexible ultrasonic transducer 31 to output ultrasonic waves according to the specifications of the target ultrasonic output parameters, thereby improving the treatment effect.

[0083] Referring to FIG. 6 , based on the same inventive concept, an embodiment of the present invention provides a non-invasive nerve regulation device control method, including:

[0084] S1. Monitor a start signal, and when a start signal is detected, generate a first start instruction and send it to the wearable flexible ultrasonic transducer 31 to control the wearable flexible ultrasonic transducer 31 to emit a first ultrasonic signal.

[0085] S2. Monitor the echo signal transmitted and reflected by the ultrasound in the body tissue at the site to be nerve-regulated.

[0086] S3. Generate an ultrasound image according to the echo signal.

[0087] Medical staff can determine the depth and status of the target organ to be neuromodulated based on the received echo signals and ultrasound images; medical staff can adjust the ultrasound output parameters to the ultrasound parameters and treatment time required for neuromodulation based on the specific location of the patient's organ to be neuromodulated, and obtain the target ultrasound output parameters.

[0088] S4. Determine the ultrasonic output parameter information of the wearable flexible ultrasonic transducer 31 according to the echo signal and the ultrasonic image.

[0089] S5. Generate a second start instruction based on the ultrasonic output parameter information and send it to the flexible ultrasonic transducer to control the flexible ultrasonic transducer to emit a second ultrasonic signal.

[0090] In the subsequent neural regulation process, the central controller 2 determines the signal strength of the second electrical signal according to the target ultrasonic output parameters, and drives the signal generator 8 to send a second electrical signal. After the second electrical signal is processed by the power amplifier 9, a second start instruction is generated and the second start instruction is sent to the wearable flexible ultrasonic transducer 31 to control the wearable flexible ultrasonic transducer 31 to output ultrasonic waves according to the specifications of the target ultrasonic output parameters, thereby reducing treatment errors and improving treatment effects.

[0091] The present application also discloses an electronic device, such as Figure 7 , which is a schematic diagram of the structure of an electronic device for a non-invasive nerve regulation device control method provided by an embodiment of the present invention. The electronic device may include at least one processor 10, a memory 11 connected to the at least one processor for communication, a communication bus 12, and a communication interface 13, and may also include a computer program stored in the memory 11 and executable on the processor 10, such as a method program for controlling a non-invasive nerve regulation device.

[0092] In some embodiments, the processor 10 may be composed of an integrated circuit, for example, a single packaged integrated circuit, or a plurality of packaged integrated circuits with the same or different functions, including one or more central processing units (CPUs), microprocessors, digital processing chips, graphics processors, and combinations of various control chips. The processor 10 is the control core (Control Unit) of the electronic device, and uses various interfaces and lines to connect the various components of the entire electronic device, and executes or executes the programs or modules stored in the memory 11 (for example, a method for executing the control of a non-invasive neural regulation device, etc.), and calls the data stored in the memory 11 to execute various functions of the electronic device and process data.

[0093] The memory 11 includes at least one type of readable storage medium, and the readable storage medium includes flash memory, mobile hard disk, multimedia card, card-type memory (for example: SD or DX memory, etc.), magnetic memory, disk, optical disk, etc. In some embodiments, the memory 11 may be an internal storage unit of an electronic device, such as a mobile hard disk of the electronic device. In other embodiments, the memory 11 may also be an external storage device of an electronic device, such as a plug-in mobile hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), etc. equipped on the electronic device. Furthermore, the memory 11 may also include both an internal storage unit of the electronic device and an external storage device. The memory 11 can not only be used to store application software and various types of data installed in the electronic device, such as the code of the method program for controlling a non-invasive neural regulation device, but also can be used to temporarily store data that has been output or is to be output.

[0094] The communication bus 12 may be a Peripheral Component Interconnect (PCI) bus or an Extended Industry Standard Architecture (EISA) bus, etc. The bus may be divided into an address bus, a data bus, a control bus, etc. The bus is configured to realize connection and communication between the memory 11 and at least one processor 10, etc.

[0095] The communication interface 13 is used for communication between the above-mentioned electronic device and other devices, including a network interface and a user interface. Optionally, the network interface may include a wired interface and / or a wireless interface (such as a WI-FI interface, a Bluetooth interface, etc.), which is generally used to establish a communication connection between the electronic device and other electronic devices. The user interface may be a display (Display), an input unit (such as a keyboard (Keyboard)), and optionally, the user interface may also be a standard wired interface, a wireless interface. Optionally, in some embodiments, the display may be an LED display, a liquid crystal display, a touch-sensitive liquid crystal display, and an OLED (Organic Light-Emitting Diode, organic light-emitting diode) touch device, etc. Among them, the display may also be appropriately referred to as a display screen or a display unit, which is used to display information processed in the electronic device and to display a visual user interface.

[0096] Figure 7 Only an electronic device with components is shown, and those skilled in the art will understand that Figure 7The structure shown does not constitute a limitation on the electronic device, and may include fewer or more components than shown, or combine certain components, or arrange the components differently. For example, although not shown, the electronic device may also include a power supply (such as a battery) for supplying power to each component. Preferably, the power supply may be logically connected to at least one processor 10 through a power management device, so that functions such as charging management, discharging management, and power consumption management are implemented through the power management device. The power supply may also include any components such as one or more DC or AC power supplies, recharging devices, power failure detection circuits, power converters or inverters, power status indicators, etc. The electronic device may also include a variety of sensors, Bluetooth modules, Wi-Fi modules, etc., which will not be repeated here.

[0097] It should be understood that the embodiment is for illustration only and the scope of the patent application is not limited by this structure.

[0098] Furthermore, if the module / unit integrated in the electronic device is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. The computer-readable storage medium can be volatile or non-volatile.

[0099] The present application provides a computer-readable storage medium, for example, including: any entity or device, recording medium, USB flash drive, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM) that can carry the computer program code. The computer-readable storage medium stores a computer program that can be loaded by a processor and execute the non-invasive neural regulation device control method of the above embodiment.

[0100] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", "an implementation", "a preferred implementation" or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0101] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A non-invasive neuromodulatory device, characterized in that: It comprises a central controller (2), and a collection module (3), a monitoring module (4), a data processing module (5) and a display module (6) which are connected to the central controller (2) for communication. The acquisition module (3) comprises at least one wearable flexible ultrasonic transducer (31) which is communicatively connected to the central controller (2), and the signal transmitting end of the wearable flexible ultrasonic transducer (31) is used to directly contact the skin of the user's part to be nerve regulated; The central controller (2) is used to control the working state of the wearable flexible ultrasonic transducer (31), and the wearable flexible ultrasonic transducer (31) emits an ultrasonic signal after being turned on; The monitoring module (4) includes a plurality of echo signal receivers arranged corresponding to the ultrasonic transducers, and the echo signal receiver (41) is used to receive the echo signal transmitted by the ultrasonic wave in the body tissue of the part to be nerve regulated and reflected back; The data processing module (5) is used to generate an ultrasonic image according to the echo signal; The display module (6) is used to display ultrasound images.

2. A non-invasive neuromodulatory device as claimed in claim 1, characterized in that: The wearable flexible ultrasonic transducer (31) comprises a piezoelectric layer, an electrode layer and a flexible substrate which are stacked in sequence, and a signal receiving end of an echo signal receiver (41) is arranged in contact with the piezoelectric layer; The electrode layer is communicatively connected to the central controller (2), and the electrode layer is connected to a power source, and the electrode layer is used to apply a voltage or receive an electrical signal; The piezoelectric layer is used to convert electrical signals into ultrasonic waves or convert ultrasonic waves into electrical signals.

3. A non-invasive neuromodulatory device as claimed in claim 2, characterized in that: The material of the piezoelectric layer is polyvinylidene fluoride or piezoelectric ceramics, and the material of the flexible substrate is polyimide or polydimethylsiloxane; the area of ​​the piezoelectric layer is greater than or equal to the area of ​​the electrode layer, and the area of ​​the flexible substrate is greater than the area of ​​the piezoelectric layer.

4. A non-invasive neuromodulatory device as claimed in claim 1, characterized in that: The step of the data processing module (5) generating an ultrasonic image according to the received echo signal comprises: Preprocessing the echo signal to obtain a preprocessed echo signal; Synthesize the pre-processed echo signals of multiple channels into one beam; The beamformed signal is scan-converted to convert the beamformed signal into an ultrasonic image.

5. A non-invasive neuromodulatory device as claimed in claim 4, characterized in that: Before performing scan conversion on the beamformed signal and converting the beamformed signal into an ultrasonic image, the method further includes: The dynamic range of the echo signal is compressed to a preset reference interval to obtain a dynamically compressed beam signal; and a data processing module (5) generates an ultrasonic image based on the dynamically compressed beam signal.

6. A non-invasive neural regulation device as claimed in claim 4, characterized in that: After the data processing module (5) performs scan conversion on the beamformed signal and converts the beamformed signal into an ultrasonic image, it further comprises: performing enhancement processing on the ultrasonic image to obtain an enhanced ultrasonic image, and sending the enhanced ultrasonic image to the display module (6); the step of performing enhancement processing on the ultrasonic image comprises: The ultrasonic image is decomposed and reconstructed by wavelet transform to obtain an enhanced ultrasonic image; Alternatively, the ultrasound image is enhanced and denoised using deep learning technology to obtain an enhanced ultrasound image.

7. The non-invasive neuromodulatory device according to claim 1, characterized in that: It also includes an input module (7) that is communicatively connected to the central controller (2), and the input module (7) is used to receive ultrasonic output parameters of the wearable flexible ultrasonic transducer (31), wherein the ultrasonic output parameters include ultrasonic intensity, frequency, irradiation time and waveform of the output ultrasonic wave.

8. A non-invasive neuromodulatory device as claimed in claim 7, characterized in that: It also includes a signal generator (8) and a power amplifier (9) which are communicatively connected to the central controller (2), wherein the signal input end of the signal generator (8) is connected to the signal output end of the central processor, the signal output end of the signal generator (8) is connected to the signal input end of the power amplifier (9), and the signal output end of the power amplifier (9) is connected to the signal input end of the flexible ultrasonic transducer; The signal generator (8) is used to generate a first electrical signal based on the ultrasonic output parameter; The power amplifier (9) is used to amplify and impedance match the first electrical signal to obtain a second electrical signal; The flexible ultrasonic transducer generates ultrasonic waves based on the second electrical signal.

9. A non-invasive nerve regulation device control method, applied to the non-invasive nerve regulation device according to any one of claims 1 to 8, characterized in that: include: Monitoring the start signal, and generating a first start instruction when the start signal is detected and sending the first start instruction to the wearable flexible ultrasonic transducer (31), so as to control the wearable flexible ultrasonic transducer (31) to emit a first ultrasonic signal; Monitor the echo signal transmitted and reflected by ultrasound in the body tissue at the site to be nerve modulated; generating an ultrasound image according to the echo signal; Determining ultrasonic output parameter information of the wearable flexible ultrasonic transducer (31) according to the echo signal and the ultrasonic image; A second start instruction is generated based on the ultrasonic output parameter information and sent to the flexible ultrasonic transducer to control the flexible ultrasonic transducer to emit a second ultrasonic signal.

10. An electronic device, characterized in that: The electronic device comprises: at least one processor (10); and, a memory (11) communicatively connected to the at least one processor (10); Wherein, the memory (11) stores a computer program that can be executed by the at least one processor (10), and the computer program is executed by the at least one processor (10) so that the at least one processor (10) can execute the non-invasive neuromodulator control method as described in claim 9.

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