Microneedle patch production method based on punching, roller cutting, waste tearing and pasting all-in-one machine

Abstract

The invention provides a microneedle patch production method based on a punching, roller cutting, waste tearing and pasting all-in-one machine, and belongs to the technical field of microneedle patch processing. The problem that according to an existing microneedle patch production method, the yield of microneedle patches is not high due to alignment error accumulation after long-time production is solved. According to the microneedle patch production method based on the punching roller cutting, waste tearing and pasting all-in-one machine, the punching roller cutting, waste tearing and pasting all-in-one machine comprises a rack, and a composite film input roller, a composite film winding roller and a waste winding roller are connected to the rack; a cutting roller tool apron, a soluble micro-needle sheet pasting and discharging table located at the rear end of the cutting roller tool apron and a soluble micro-needle sheet punching table located on one side of the soluble micro-needle sheet pasting and discharging table are arranged on the rack, and a truss mechanical arm is arranged on the portion, between the cutting roller tool apron and the soluble micro-needle sheet pasting and discharging table, of the rack in the transverse direction. According to the microneedle patch production method based on the punching, roller cutting, waste tearing and pasting all-in-one machine, it can be guaranteed that in the long-time production process, the yield of microneedle patches is high, and discharging is convenient and fast.

Description

Technical Field

[0001] The invention belongs to the technical field of microneedle patch processing, and relates to a microneedle patch production method based on a punching roller cutting, tearing, scrapping and pasting all-in-one machine. Background Art

[0002] like Figure 1 As shown, the microneedle patch is punched out from the soluble microneedle original sheet into a plurality of groups of arc-shaped soluble microneedle sheets 9, and then the composite film 1 is roll-cut to form a film to be bonded 10 and a cutting waste 8 after rolling. The film to be bonded 10 contains a waist-shaped waist-shaped sheet 2, and the inner edge of the back adhesive layer 22 in the waist-shaped sheet 2 has an inner adhesive surface 22a with the back adhesive exposed. The waist-shaped sheet 2 is provided with a make-way opening 21a opened along its own length direction at the left and right ends of the release paper layer 21. The microneedle patch is formed by pasting the soluble microneedle sheet 9 on the inner adhesive surface 22a of the waist-shaped sheet 2.

[0003] Existing methods for producing microneedle patches, such as Chinese patent application [Authorization Announcement No.: CN113548511B], discloses a method for processing microneedle eye patches, comprising the following steps: S1, synchronously compounding two waste tapes onto a first low-viscosity film tape to form a first conveyor tape, and the two rows of waste tapes are respectively arranged close to the side edges of the first low-viscosity film tape, and the spacing between the two rows of waste tapes is less than the width of the microneedle original sheet; S2, pasting the microneedle original sheet face up onto the first conveyor tape in sequence to form a second conveyor tape; S3, die-cutting the second conveyor tape to die-cut the microneedle original sheet into a plurality of eye patch sheets, and separating the waste tape together with the cut microneedle original sheet contour waste from the second conveyor tape to form a third conveyor tape; S4, peeling the third conveyor tape to remove the eye patch sheet from the first low-viscosity film S5, compound the medical adhesive tape onto the second low-viscosity film tape, and separate and collect the release film on the medical adhesive tape to form a fourth conveyor tape; S6, die-cut the fourth conveyor tape, cut the medical adhesive tape into several medical adhesive sheets, and collect the cut medical adhesive contour waste to obtain a fifth conveyor tape; S7, paste the eye patch sheet peeled off in step 4 onto the medical adhesive sheet on the fifth conveyor tape to form a sixth conveyor tape, and the back side of the eye patch sheet is pasted to one side of the medical adhesive sheet to form a microneedle eye patch; S8, peel off the sixth conveyor tape, peel off the microneedle eye patch from the second low-viscosity film tape, and the peeled microneedle eye patch falls on the conveyor belt in turn for transportation, and collect the second low-viscosity film tape.

[0004] The above structure is achieved by first cutting the microneedle original sheet of the first low-viscosity film tape to form a number of eye patch sheets after cutting, and then compounding the second low-viscosity film tape and the medical adhesive tape, and then cutting the two, and then pasting the eye patch sheets on the first low-viscosity film tape to the medical adhesive sheets on the fifth conveyor belt after cutting, thereby realizing the production of microneedle eye patches. However, the eye patch sheets are pasted on block-shaped medical adhesive sheets, and the entire eye patch sheet cannot be sealed during use, and the water evaporated from the human body cannot be utilized. Another water film needs to be used to provide water to achieve the dissolution of the eye patch sheet, which makes the eye patch sheet inconvenient to use. Moreover, since the cut eye patch sheets need to be pasted on the corresponding medical adhesive sheets, during long-term production, the alignment error will gradually accumulate, resulting in the alignment error between the eye patch sheet and the medical adhesive sheet continuously increasing, reducing the yield of long-term production and affecting the normal production efficiency of the microneedle patch. Summary of the invention

[0005] The purpose of the present invention is to address the above-mentioned problems in the existing technology and propose a microneedle patch production method based on a punching roller cutting, tearing and pasting all-in-one machine. The technical problem to be solved by the present invention is: how to solve the problem of low microneedle patch yield caused by the accumulation of positioning errors after long-term production in the existing microneedle patch production method.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] A method for producing a microneedle patch based on a punching and cutting roller cutting, tearing and pasting integrated machine, the punching and cutting roller cutting, tearing and pasting integrated machine comprising a frame, the frame being connected with a composite film input roller, a composite film winding roller and a waste winding roller, the frame being provided with a cutting roller knife seat, a soluble microneedle sheet pasting unloading platform located at the rear end of the cutting roller knife seat and a soluble microneedle sheet punching platform located at one side of the soluble microneedle sheet pasting unloading platform, the frame being arranged transversely between the cutting roller knife seat and the soluble microneedle sheet pasting unloading platform There is a truss manipulator, the cutting roller knife seat includes a cutting roller and a bottom roller, the cutting roller includes multiple groups of roller blade groups arranged along the circumference of the cutting roller and multiple pairs of connecting roller knives arranged along the circumference of the cutting roller, each group of roller blade groups includes waist-shaped roller blade one, roller blade two and roller blade three, roller blade three is located at the outermost side, the connecting roller knife connects the roller blades two of the two adjacent roller blade groups, and a reserved notch is opened at the intersection of roller blade three and the connecting roller knife. The microneedle patch production method comprises the following steps:

[0008] S1. Film loading: placing the composite film on the composite film input roller, passing one end of the composite film between the cutting roller and the bottom roller, and then pulling the composite film through the soluble microneedle sheet pasting feed table, and one end of the composite film is pulled out from the soluble microneedle sheet pasting feed table and rolled up on the composite film winding roller;

[0009] S2. Debugging and positioning: adjust the pressure of the cutting roller of the cutting roller holder on the pressing roller, and move the cutting roller down to press the composite film tightly on the bottom roller;

[0010] S3, preliminary roller cutting: drive the cutting roller, bottom roller and composite film winding roller to rotate synchronously, the cutting roller and bottom roller cut the composite film and form cutting waste, after continuous cutting, when the cutting waste reaches a certain length, the cutting roller, bottom roller and composite film winding roller stop running, and then the end of the cutting waste is pasted on the waste winding roller;

[0011] S4, roller cutting and forming: drive the cutting roller, bottom roller, composite film winding roller and waste winding roller to rotate synchronously, and at the same time drive the soluble microneedle sheet punching station to punch the soluble microneedle original sheet to form multiple soluble microneedle sheets. The composite film forms a film to be bonded after roller cutting. The two ends of the waist-shaped sheet in the film to be bonded are connected to the film to be bonded at the reserved notch. The soluble microneedle sheet pasting unloading station tensions the film to be bonded, and the truss manipulator is started. The truss manipulator slides to the soluble microneedle punching station and absorbs the soluble microneedle sheet. After absorption, the truss manipulator slides in the opposite direction and slides to the top of the film to be bonded, and then drives the truss manipulator downward and drives the soluble microneedle sheet to press against the waist-shaped sheet of the film to be bonded, so that the soluble microneedle sheet is bonded to the inner bonding surface of the adhesive layer on the waist-shaped sheet;

[0012] S5, unloading: continue to drive the truss manipulator downward, and drive the soluble microneedle sheet to move down and press against the film to be bonded on the unloading table for bonding the soluble microneedle sheet. The unloading plate sucks the waist-shaped sheet and cooperates with the truss manipulator to pull the waist-shaped sheet off the film to be bonded. The unloading plate releases the suction on the waist-shaped sheet and rotates to unload the material.

[0013] Before production, the pressure between the cutting roller and the bottom roller on the cutting roller holder is adjusted so that the cutting roller presses the composite film against the bottom roller. After adjustment, preliminary roll cutting is performed. The cutting roller and the bottom roller of the cutting roller holder are driven to roll cut the composite film. The cutting waste can be pulled out during the rolling process. When the cutting waste accumulates enough, the cutting roller, the bottom roller and the composite film winding roller are directly turned off, and the end of the cutting waste is pasted on the waste winding roller, so that the cutting waste is pulled out and fixed after the preliminary roll cutting. After the cutting waste is fixed, the cutting roller and the bottom roller are driven again to cut the composite film. After cutting, cutting waste and the film to be laminated are formed. At the same time, the soluble microneedle sheet punching station cuts the soluble microneedle original sheet by stamping. , cut into multiple soluble microneedle sheets, the soluble microneedle sheets are grabbed by a truss manipulator arranged between the cutting roller knife seat and the soluble microneedle sheet pasting and unloading table, and then moved and pressed downward on the waist-shaped sheet of the film to be bonded, and the bonding is achieved through the inner adhesive surface reserved in the back adhesive layer of the waist-shaped sheet. At the same time, the truss manipulator continues to press down and presses down the waist-shaped sheet with the soluble microneedle sheet. The cut waist-shaped sheet is only connected to the film to be bonded at the reserved notch. Therefore, under the action of the downward pressure of the truss manipulator and the downward suction force of the unloading tray, the two ends of the waist-shaped sheet are directly broken from the film to be bonded, the unloading tray releases the suction on the waist-shaped sheet, and the unloading tray is rotated to realize the unloading of the waist-shaped sheet, thereby completing the production of the microneedle patch.

[0014] The above structure only uses the cooperation of the cutting roller and the bottom roller to realize the cutting of the annular waist-shaped sheet, and the waist-shaped sheet and the film to be bonded are set with reserved notches, so that the two ends of the waist-shaped sheet are connected to the film to be bonded only at the reserved notches. The cutting waste after cutting is initially positioned by manually taking out and sticking it on the waste winding roller. During production, the waste winding roller rotates synchronously to realize the winding of the cutting waste, and the rotation of the composite film winding roller realizes the winding of the film to be bonded after cutting, and then the soluble microneedle sheet after punching is pressed onto the waist-shaped sheet by the truss manipulator. In the entire production process, the method of compounding after cutting with multiple groups of raw materials is not adopted, which avoids the position error accumulated during roller pressing and compounding. The truss manipulator is also coordinated with the unloading tray to realize the rapid and stable separation of the waist-shaped sheet from the film to be bonded, and the rapid unloading of the waist-shaped sheet is realized. This production method can ensure that the yield of the microneedle patch is high and the unloading is convenient and quick during a long production process.

[0015] A driven gear 1 is sleeved on one end of the cutting roller, a driven gear 2 is sleeved on one end of the bottom roller, a driving rod is rotatably connected to the cutting roller knife seat, a driving gear is sleeved on the driving rod, the driving gear is meshed with the driven gear 2, the driven gear 2 is meshed with the driven gear 1, a cutting motor is connected to the frame, the motor shaft of the cutting motor is fixedly connected to the driving rod, the cutting motor is driven, the motor shaft of the cutting motor drives the driving rod to rotate, the driving gear of the driving rod drives the driven gear 2 to rotate, the driven gear 2 rotates and drives the driven gear 1 to rotate, thereby realizing the cutting of the composite film by the cutting roller and the bottom roller.

[0016] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, in the step S4, when the cutting roller and the bottom roller are in operation, roller blade one fully cuts the inner hole of the waist-shaped sheet, roller blade three fully cuts the outer edge of the waist-shaped sheet, and connecting notches are provided at both ends of roller blade two. The end of the connecting roller knife connects the roller blades two of the two adjacent roller blade groups with the corresponding connecting notches, and the connecting roller knife and roller blade two both cut the release paper layer on the waist-shaped sheet.

[0017] By opening a connecting notch on roller blade two, roller blade two and the connecting roller knife only cut the release paper layer on the composite film during cutting, so that the strip-shaped release paper layer is cut off to form cutting waste, and a reserved notch is opened at the intersection of the connecting roller knife and roller blade three by roller blade three, so that the waist-shaped sheet after cutting is only connected to the film to be bonded at the reserved notch, which is convenient for the subsequent unloading of the waist-shaped sheet. The arrangement of multiple groups of roller blade groups and multiple pairs of connecting roller knives on the cutting roller can not only ensure that the cutting waste after cutting is not a broken sheet, but a strip that can be pulled out, and through the arrangement of the reserved notch, the waist-shaped sheet will not separate from the film to be bonded when the film to be bonded moves, but will quickly separate with the cooperation of the truss manipulator and the unloading tray, thereby realizing stable cutting production and unloading of the microneedle patch, and ensuring the yield of the microneedle patch while improving production efficiency.

[0018] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting integrated machine, in the step S4, the diameter of the reserved gap is 0.1mm to 0.9mm.

[0019] The diameter of the reserved notch is limited. Within this size, the waist-shaped sheet can be stably set on the film to be bonded during movement without detachment, and can also be quickly unloaded with the cooperation of the truss robot and the unloading tray, thereby improving the stability of production and unloading.

[0020] The best diameter of the reserved notch is 0.3mm to 0.6mm.

[0021] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, in the step S4, the edge height of the roller blade one is equal to the edge height of the roller blade three, and the edge height of the roller blade two is equal to the edge height of the connecting roller blade.

[0022] Since roller blade one and roller blade three need to completely cut the release paper layer and the adhesive layer of the composite film, and roller blade two and the connecting roller blade need to cut the adhesive layer on the composite film, the height of the blade edges of the four roller blades are directly set, so that the composite film can be cut stably during the roller cutting process, thereby improving the cutting stability.

[0023] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, two guide rods distributed up and down are connected to the rear end of the cutting roller knife seat. In the step S4, one end of the cut waste after the composite film is cut is pulled out from the lower side of the guide rod located above and abuts against the guide rod and then is wound up by the waste winding roller. The cut film to be pasted is tensioned by the guide rod located below and set on the soluble microneedle patch pasting unloading table.

[0024] The setting of two guide rods can realize the guiding and tensioning of the cutting waste after cutting and the film to be bonded after cutting. In order not to affect the subsequent processing of the film to be bonded, the winding of the cutting waste and the tensioning guide of the film to be bonded are separated up and down, which improves the stability of production and facilitates the winding of the cutting waste.

[0025] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, the waste winding roller is located obliquely above the cutting roller knife seat, and the waste winding roller is arranged parallel to the cutting roller. In the step S3, the composite film is cut by the cutting roller and the bottom roller to produce a plurality of cutting wastes, and the ends of the plurality of cutting wastes are placed along the length direction of the waste winding roller and pasted on the waste winding roller.

[0026] The positions of the waste winding roller and the cutting roller seat are set. When the cut waste is wound up, it is only necessary to make the rotation speed of the waste winding roller equal to the rotation speed of the cutting roller, and the ends of the cut waste can be pasted in sequence along the length direction of the waste winding roller, so that the waste winding roller can quickly and stably wind up the cut waste.

[0027] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, the front end of the soluble microneedle sheet pasting unloading platform is fixedly connected with a tensioning roller, and the tensioning roller is located obliquely below the guide rod. The front and rear ends of the soluble microneedle sheet pasting unloading platform are respectively fixedly connected with support rollers, and the two support rollers are arranged in parallel with the tensioning roller. In the step S4, the tensioning roller is located obliquely below the guide rod and the cut film to be pasted is pulled out from the lower side of the tensioning roller and pasted and tensioned. One end of the film to be pasted is pulled upward from between the tensioning roller and the support roller and tensioned by the tensioning roller. After being pulled out, it is pulled out and tensioned by the upper side of another tensioning roller. The tensioned film to be pasted is arranged horizontally.

[0028] The setting of the tensioning roller allows the film to be bonded to cooperate with the tensioning roller and the corresponding guide rod to achieve tensioning of the film to be bonded and improve the tensioning effect of the film to be bonded. The support roller and the tensioning roller cooperate with each other, and the film to be bonded can be tensioned by the tensioning roller and the support roller, so that the film to be bonded on the unloading table for the soluble microneedle sheet can be set horizontally, which is convenient for the truss robot to press down and the waist-shaped sheet of the film to be bonded to be separated, thereby improving the production efficiency and stability of the microneedle patch.

[0029] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, the truss manipulator has two suction plates that can move in the front and rear directions, and each suction plate is provided with multiple groups of suction heads. In the step S4, there are multiple pairs of soluble microneedle sheets punched out after the punching base, and the suction heads of the two suction plates absorb the multiple pairs of soluble microneedle sheets at intervals. After absorption, the truss manipulator slides laterally to move the two suction plates away from each other, and then the soluble microneedle sheets are placed on the inner bonding surface of the film to be bonded.

[0030] Since it is necessary to cut smaller soluble microneedle sheets as much as possible in order to use them, the cut soluble microneedle sheets are closely spaced. Multiple pairs of soluble microneedle sheets are sucked at intervals by the suction plate, and then the suction plates are moved away from each other to place the soluble microneedle sheets on the inner bonding surface of the film to be bonded. Through the intermittent suction method, the suction plate of the truss robot only moves in one direction, thereby improving the stability of suction.

[0031] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, a plurality of suction holes are opened on the discharge tray, and a cylinder is connected to the soluble microneedle patch pasting discharge table. In the step S5, the cylinder is started, and the discharge tray vacuum adsorbs the waist-shaped sheet on the upper end surface of the discharge tray through the suction hole to separate the waist-shaped sheet from the film to be pasted, and the cylinder is closed to release the suction of the waist-shaped sheet.

[0032] When unloading, multiple suction holes are opened on the unloading tray, and the air cylinder is used to control whether the suction holes are sucking air, so that the waist-shaped piece is vacuum-adsorbed on the upper end surface of the unloading tray, and then the air cylinder is closed to release the suction of the waist-shaped piece by the unloading tray.

[0033] In the above-mentioned microneedle patch production method based on the punching roller cutting, tearing and pasting machine, a feeding shaft is hinged on the soluble microneedle patch pasting feeding table, and the front end of the lower end surface of the feeding tray is fixedly connected to the middle part of the feeding shaft. In the step S5, the cylinder is closed and the feeding cylinder is started, the feeding cylinder drives the feeding shaft to rotate, and the middle part of the feeding shaft drives the rear end of the feeding tray to flip downward.

[0034] When unloading, the unloading tray is driven to swing by the rotation of the unloading shaft. Therefore, in order to reduce the swing amplitude, the middle part of the unloading shaft is directly connected to the front end of the lower end surface of the unloading tray, so that the unloading shaft can quickly drive the rear end of the unloading tray to flip downward when rotating, thereby realizing rapid unloading.

[0035] The unloading cylinder is a rotary cylinder.

[0036] Compared with the prior art, the present microneedle patch production method based on the punching roller cutting, tearing and pasting integrated machine has the following advantages: the cooperation of the cutting roller and the bottom roller realizes the cutting of the annular waist-shaped sheet, and the cut waste after cutting is initially positioned by manually taking out and pasting it on the waste winding roller. During production, the waste winding roller rotates synchronously to realize the winding of the cut waste, and the rotation of the composite film winding roller realizes the winding of the cut film to be bonded, and then the punched soluble microneedle sheet is pressed onto the waist-shaped sheet by the truss manipulator. During the entire production process, the method of compounding after cutting with multiple groups of raw material rollers is not adopted, which avoids the accumulated position error during roller pressing and compounding. The truss manipulator is also coordinated with the unloading tray to realize the rapid and stable separation of the waist-shaped sheet from the film to be bonded, and the rapid unloading of the waist-shaped sheet is realized. The present production method can ensure that the yield of the microneedle patch is high and the unloading is convenient and quick during a long production process. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a schematic diagram of the existing composite film cutting process and the structure of the soluble microneedle sheet.

[0038] Figure 2 yes Figure 1 A partial enlarged view of point A in the middle.

[0039] Figure 3 It is a structural schematic diagram of the roller laminating machine used in the production method during processing.

[0040] Figure 4 It is a partial cross-sectional view of the roller laminating machine used in the production method during processing.

[0041] Figure 5 It is a structural schematic diagram of the cutting roller in the roller laminating machine used in the production method.

[0042] Figure 6 yes Figure 5 A partial enlarged view of point B in the middle.

[0043] Figure 7 It is a structural schematic diagram of a cutting roller knife seat in a roller laminating machine used in the production method.

[0044] Figure 8 It is one of the structural schematic diagrams of the soluble microneedle sheet pasting unloading table in the roller pasting integrated machine used in the production method.

[0045] Fig. 9 This is the second structural schematic diagram of the soluble microneedle sheet pasting unloading platform in the roller pasting integrated machine used in the production method.

[0046] Fig.10 It is a partial structural schematic diagram of the truss manipulator in the roller laminating machine used in the production method.

[0047] Fig.11 It is a schematic diagram showing that the microneedle sheet on the soluble microneedle original sheet is not bonded to the film to be bonded in the production method.

[0048] Fig.12 It is a schematic diagram of the microneedle sheet portion on the soluble microneedle original sheet being bonded to the film to be bonded in the production method.

[0049] In the figure, 1, composite film; 2, waist-shaped sheet; 21, release paper layer; 21a, clearance opening; 22, adhesive layer; 22a, inner adhesive surface; 3, frame; 31, composite film input roller; 32, composite film winding roller; 33, waste winding roller; 34, cutting motor; 35, slide rail; 4, cutting roller blade seat; 41, cutting roller; 41a, pressure ring 2; 41b, roller blade 1; 41c, roller blade 2; 41c1, connecting gap; 41d, roller blade 3; 41d1, reserved gap; 41e, connecting roller blade; 41f, driven gear 1; 42, bottom roller; 42a, driven gear 2; 4 3. Rotating screw; 44. Pressing rod; 44a. Pressing ring 1; 45. Guide rod; 46. Cutting gap; 47. Driving rod; 47a. Driving gear; 5. Soluble microneedle sheet pasting unloading platform; 51. Unloading plate; 51a. Suction hole; 52. Tensioning roller; 53. Support roller; 54. Unloading shaft; 55. Unloading cylinder; 56. Cylinder; 6. Soluble microneedle sheet punching platform; 61. Punching cylinder; 62. Punching base; 7. Truss manipulator; 71. Suction plate; 72. Suction head; 8. Cutting waste; 9. Soluble microneedle sheet; 10. Film to be pasted; 101. Soluble microneedle original sheet. DETAILED DESCRIPTION

[0050] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0051] like Figure 1-3 As shown, the present microneedle patch production method based on the punching roller cutting, tearing and pasting integrated machine, the roller pasting integrated machine includes a frame 3, the frame 3 is connected with a composite film input roller 31, a composite film winding roller 32 and a waste winding roller 33, the frame 3 is provided with a cutting roller knife seat 4, a soluble microneedle sheet pasting unloading platform 5 located at the rear end of the cutting roller knife seat 4 and a soluble microneedle sheet punching platform 6 located at one side of the soluble microneedle sheet pasting unloading platform 5, the frame 3 is provided with a truss manipulator 7 along the horizontal direction between the cutting roller knife seat 4 and the soluble microneedle sheet pasting unloading platform 5, the cutting roller knife seat 4 includes a cutting roller 41 and a bottom roller 42, The cutting roller 41 includes multiple groups of roller blade groups arranged along the circumference of the cutting roller 41 and multiple pairs of connecting roller cutters 41e arranged along the circumference of the cutting roller 41. Each group of roller blade groups includes waist-shaped roller blade one 41b, roller blade two 41c and roller blade three 41d. Roller blade three 41d is located at the outermost side. The connecting roller cutter 41e connects roller blade two 41c of two adjacent roller blade groups. A reserved notch 41d1 is provided at the intersection of roller blade three 41d and connecting roller cutter 41e. The waste winding roller 33 is located obliquely above the cutting roller cutter seat 4, and the waste winding roller 33 is arranged parallel to the cutting roller 41.

[0052] Specifically, Figure 1-12 As shown, the production method comprises the following steps:

[0053] S1, film loading: placing the composite film 1 on the composite film input roller 31, one end of the composite film 1 first passes through the cutting roller 41 and the bottom roller 42, and then the composite film 1 is pulled out through the soluble microneedle sheet pasting feed station 5, and one end of the composite film 1 is pulled out from the soluble microneedle sheet pasting feed station 5 and rolled up on the composite film winding roller 32;

[0054] S2, debugging and positioning: adjust the pressure of the cutting roller 41 of the cutting roller holder 4 on the bottom roller 42, the cutting roller 41 moves downward to press the composite film 1 against the bottom roller 42, adjust the rotating screw 43 on the cutting roller holder 4 to drive the pressure rod 44 to press against the sleeved pressure ring 1 44a of the cutting roller 41, the cutting roller 41 slides downward to press the composite film 1 against the bottom roller 42, adjust the cutting gap 46 between the cutting roller 41 and the bottom roller 42, so that when the cutting roller 41 and the bottom roller 42 are not driven, the composite film 1 cannot be pulled out from between the cutting roller 41 and the bottom roller 42;

[0055] S3, preliminary roller cutting: the machine starts to run, driving the cutting roller 41, the bottom roller 42 and the composite film winding roller 32 to rotate synchronously, the cutting roller 41 and the bottom roller 42 cut the composite film 1, and the cutting waste 8 is formed after cutting. After continuous cutting, when the cutting waste 8 reaches a certain length, the machine is turned off, the cutting roller 41, the bottom roller 42 and the composite film winding roller 32 stop running, and then the end of the cutting waste 8 is pasted on the waste winding roller 33, and the diameter of the reserved gap 41d1 is 0.1mm~0.9mm;

[0056] After the composite film 1 is cut by the cutting roller 41 and the bottom roller 42, a plurality of cutting wastes 8 are generated, and the ends of the plurality of cutting wastes 8 are placed along the length direction of the waste winding roller 33 and pasted on the waste winding roller 33;

[0057] A driven gear 1 41f is sleeved on one end of the cutting roller 41, a driven gear 2 42a is sleeved on one end of the bottom roller 42, a driving rod 47 is rotatably connected to the cutting roller knife seat 4, a driving gear 47a is sleeved on the driving rod 47, the driving gear 47a is meshed with the driven gear 2 42a, the driven gear 2 42a is meshed with the driven gear 1 41f, a cutting motor 34 is connected to the frame 3, the motor shaft of the cutting motor 34 is fixedly connected to the driving rod 47, the cutting motor 34 is driven, the motor shaft of the cutting motor 34 drives the driving rod 47 to rotate, the driving gear 47a of the driving rod 47 drives the driven gear 2 42a to rotate, the driven gear 2 42a rotates and drives the driven gear 1 41f to rotate, so as to realize the cutting of the composite film 1.

[0058] S4, roller cutting and forming: run the machine again, drive the cutting roller 41, the bottom roller 42, the composite film winding roller 32 and the waste winding roller 33 to rotate synchronously, and at the same time drive the soluble microneedle sheet punching station 6 to punch the soluble microneedle original sheet 101, the composite film 1 forms a to-be-bonded film 10 after roller cutting, the two ends of the waist-shaped sheet 2 are connected to the to-be-bonded film 10 at the reserved notch 41d1, the soluble microneedle original sheet 101 is punched into a waist-shaped soluble microneedle sheet 9, the soluble microneedle sheet pasting unloading station 5 tightens the to-be-bonded film 10, start the truss manipulator 7, the truss manipulator 7 slides to the soluble microneedle punching station 6 and absorbs the soluble microneedle sheet 9, and after absorption, start the truss manipulator 7 again to slide in the opposite direction, slide to the top of the to-be-bonded film 10, and then drive the truss manipulator 7 to move downward and drive the soluble microneedle sheet 9 to press against the waist-shaped sheet of the to-be-bonded film 10 2, so that the soluble microneedle sheet 9 is bonded to the inner adhesive surface 22a of the back adhesive layer 22 on the waist-shaped sheet 2, when the cutting roller 41 and the bottom roller 42 are running, the roller blade 1 41b completely cuts the inner hole of the waist-shaped sheet 2, and the roller blade 3 41d completely cuts the outer edge of the waist-shaped sheet 2, and the roller blade 2 41c is provided with a connecting notch 41c1 at both ends, and the end of the connecting roller blade 41e is connected to the roller blades 2 41c of the two adjacent roller blade groups with the corresponding connecting notch 41c1, and the connecting roller blade 41e and the roller blade 2 41c both cut the release paper layer 21 on the waist-shaped sheet 2, and the edge height of the roller blade 1 41b is equal to the edge height of the roller blade 3 41d, and the edge height of the roller blade 2 41c is equal to the edge height of the connecting roller blade 41e, and the waist-shaped sheet 2 after cutting is only connected to the film 10 to be laminated at the reserved notches 41d1 at both ends;

[0059] The soluble microneedle sheet punching station 6 is provided with a punching cylinder 61, and a punching knife is connected to the piston rod of the punching cylinder 61. The frame 1 is fixedly connected with a slide rail 35 arranged along the left and right sides, and a punching base 62 is slidably connected to the slide rail 35. The punching base 62 attracts the soluble microneedle original sheet 101 through the cylinder and the vent hole, and the punching cylinder 61 is started, and the punching cylinder 61 drives the punching knife to punch the soluble microneedle original sheet 101 on the punching base 62;

[0060] The truss manipulator 7 has two suction plates 71 that can move in the front-to-back direction, and each suction plate 71 is provided with multiple groups of suction heads 72. In the step S4, there are multiple pairs of soluble microneedle sheets 9 punched out after the punching base 62, and the suction heads 72 of the two suction plates 71 suck the multiple pairs of soluble microneedle sheets 9 at intervals. After sucking, the truss manipulator 7 slides laterally to move the two suction plates 71 away from each other, and then the soluble microneedle sheet 9 is placed on the inner bonding surface 22a of the film 10 to be bonded.

[0061] S5, unloading: continue to drive the truss manipulator 7 to move downward, and drive the soluble microneedle sheet 9 to move downward and press against the waist-shaped sheet 2 on the soluble microneedle sheet pasting unloading platform 5, the unloading plate 51 sucks the waist-shaped sheet 2 and cooperates with the truss manipulator 7 to pull the waist-shaped sheet 2 off the film to be bonded 10, and the unloading plate 51 releases the suction on the waist-shaped sheet 2 and rotates to unload.

[0062] Furthermore, if Figure 3 , Figure 4 , Figure 7 and Figure 8 As shown, the rear end of the cutting roller knife seat 4 is connected to two guide rods 45 distributed in the upper and lower directions, and the cutting gap 46 between the cutting roller 41 and the bottom roller 42 is located between the two guide rods 45. The front end of the soluble microneedle sheet pasting unloading platform 5 is fixedly connected to a tensioning roller 52 and a supporting roller 53, and the rear end is fixedly connected to another supporting roller 53. The two supporting rollers 53 are arranged in parallel with the tensioning roller 52. In step S4, one end of the cut waste 8 is pulled out from the lower side of the guide rod 45 located above and abuts against the guide rod 45. The rod 45 is then wound up by the waste winding roller 33, and the cut film 10 to be bonded is tensioned by the guide rod 45 located below and set on the soluble microneedle sheet pasting unloading table 5, one end of the film 10 to be bonded is pulled upward from between the tensioning roller 52 and the supporting roller 53 and tensioned by the tensioning roller 52, one end of the film 10 to be bonded is pulled upward from the upper side of the tensioning roller 52 and tensioned, and after being pulled out, it is pulled out and tensioned by the upper side of another tensioning roller 52, and the tensioned film 10 to be bonded is set horizontally.

[0063] Furthermore, if Figure 3 , Figure 4 , Figure 8 and Fig. 9 As shown, a plurality of suction holes 51a are provided on the discharge tray 51, a cylinder 56 is connected to the discharge platform 5 for pasting the soluble microneedle sheet, a discharge shaft 54 ​​is hinged on the discharge platform 5 for pasting the soluble microneedle sheet, the front end of the lower end surface of the discharge tray 51 is fixedly connected to the middle part of the discharge shaft 54, in step S5, the cylinder 56 is started, the discharge tray 51 vacuum adsorbs the waist-shaped sheet 2 on the upper end surface of the discharge tray 51 through the suction holes 51a to separate the waist-shaped sheet 2 from the film 10 to be pasted, the cylinder 56 is closed and the discharge cylinder 55 is started to release the suction of the waist-shaped sheet 2, the discharge cylinder 55 drives the discharge shaft 54 ​​to rotate, and the middle part of the discharge shaft 54 ​​drives the rear end of the discharge tray 51 to flip downward.

[0064] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A method for producing a microneedle patch based on a punching and cutting roller cutting and tearing waste pasting machine, the punching and cutting roller cutting and tearing waste pasting machine comprising a frame (3), the frame (3) being connected to a composite film input roller (31), a composite film winding roller (32) and a waste material winding roller (33), the frame (3) being provided with a cutting roller knife seat (4), a soluble microneedle sheet pasting unloading platform (5) located at the rear end of the cutting roller knife seat (4), and a soluble microneedle sheet punching and cutting platform (6) located at one side of the soluble microneedle sheet pasting unloading platform (5), a unloading tray (51) being provided in the soluble microneedle sheet pasting unloading platform (5), the frame (3) being provided with a plurality of holes between the cutting roller knife seat (4) and the soluble microneedle sheet pasting unloading platform (5) A truss manipulator (7) is arranged in the transverse direction between the two roller blades. The cutting roller blade seat (4) comprises a cutting roller (41) and a bottom roller (42). The cutting roller (41) comprises a plurality of roller blade groups arranged along the circumference of the cutting roller (41) and a plurality of connecting roller blades (41e) arranged along the circumference of the cutting roller (41). Each roller blade group comprises a waist-shaped roller blade one (41b), a roller blade two (41c) and a roller blade three (41d). The roller blade three (41d) is located at the outermost side. The connecting roller blade (41e) connects the roller blades two (41c) of two adjacent roller blade groups. A reserved notch (41d1) is provided at the intersection of the roller blade three (41d) and the connecting roller blade (41e). It is characterized in that The microneedle patch production method comprises the following steps: S1, film loading: placing the composite film (1) on the composite film input roller (31), one end of the composite film (1) first passes through between the cutting roller (41) and the bottom roller (42), then the composite film (1) is pulled out through the soluble microneedle sheet pasting feed table (5), one end of the composite film (1) is pulled out from the soluble microneedle sheet pasting feed table (5) and rolled up on the composite film winding roller (32); S2, debugging and positioning: adjusting the pressure of the cutting roller (41) of the cutting roller holder (4) on the bottom roller (42), and moving the cutting roller (41) downward until the composite film (1) is pressed tightly against the bottom roller (42); S3, preliminary roller cutting: driving the cutting roller (41), the bottom roller (42) and the composite film winding roller (32) to rotate synchronously, the cutting roller (41) and the bottom roller (42) cut the composite film (1) and form cutting waste (8), and when the cutting waste (8) reaches a certain length after continuous cutting, the cutting roller (41), the bottom roller (42) and the composite film winding roller (32) stop running, and then the end of the cutting waste (8) is attached to the waste winding roller (33); S4, roller cutting and forming: driving the cutting roller (41), the bottom roller (42), the composite film winding roller (32) and the waste winding roller (33) to rotate synchronously, and driving the soluble microneedle sheet punching table (6) to punch the soluble microneedle original sheet (101) to form a plurality of soluble microneedle sheets (9), the composite film (1) is formed into a film to be bonded (10) after roller cutting, the two ends of the inner waist-shaped sheet (2) of the film to be bonded (10) are connected to the film to be bonded (10) at the reserved notch (41d1), and the soluble microneedle sheet is pasted to the unloading table (5) The film to be bonded (10) is tensioned, and the truss manipulator (7) is started. The truss manipulator (7) slides to the soluble microneedle punching table (6) and absorbs the soluble microneedle sheet (9). After absorption, the truss manipulator (7) slides in the opposite direction to be located above the film to be bonded (10), and then the truss manipulator (7) is driven downward to drive the soluble microneedle sheet (9) to press against the waist-shaped sheet (2) of the film to be bonded (10), so that the soluble microneedle sheet (9) is bonded to the inner bonding surface (22a) of the back adhesive layer (22) on the waist-shaped sheet (2); S5, unloading: continue to drive the truss manipulator (7) downward, and drive the soluble microneedle sheet (9) downward to press against the waist-shaped sheet (2) on the unloading platform (5) for the soluble microneedle sheet to be pasted, the unloading plate (51) sucks the waist-shaped sheet (2) and cooperates with the truss manipulator (7) to pull the waist-shaped sheet (2) off the film to be bonded (10), and the unloading plate (51) releases the suction force on the waist-shaped sheet (2) and rotates to unload the material.

2. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 1, characterized in that: In step S4, when the cutting roller (41) and the bottom roller (42) are in operation, roller blade one (41b) completely cuts the inner hole of the waist-shaped sheet (2), roller blade three (41d) completely cuts the outer edge of the waist-shaped sheet (2), and roller blade two (41c) is provided with connecting notches (41c1) at both ends. The end of the connecting roller blade (41e) and the corresponding connecting notch (41c1) connect the roller blades (41c) of two adjacent roller blade groups, and the connecting roller blade (41e) and roller blade two (41c) both cut the release paper layer (21) on the waist-shaped sheet (2).

3. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 2, characterized in that: In the step S4, the diameter of the reserved gap (41d1) is 0.1 mm to 0.9 mm.

4. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 2 or 3, characterized in that: In step S4, the cutting edge height of the roller blade one (41b) is equal to the cutting edge height of the roller blade three (41d), and the cutting edge height of the roller blade two (41c) is equal to the cutting edge height of the connecting roller blade (41e).

5. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 4, characterized in that: The rear end of the cutting roller knife seat (4) is connected to two guide rods (45) distributed in an upper and lower direction. In the step S4, one end of the cut waste (8) after the composite film (1) is cut is pulled out from the lower side of the guide rod (45) located at the top and abuts against the guide rod (45) before being rolled up by the waste winding roller (33). The cut film (10) to be bonded is tensioned by the guide rod (45) located at the bottom and is set on the soluble microneedle sheet bonding unloading platform (5).

6. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 5, characterized in that: The scrap winding roller (33) is located obliquely above the cutting roller blade seat (4), and the scrap winding roller (33) is arranged parallel to the cutting roller (41). In the step S3, the composite film (1) is cut by the cutting roller (41) and the bottom roller (42) to generate a plurality of cutting scraps (8). The ends of the plurality of cutting scraps (8) are placed along the length direction of the scrap winding roller (33) and adhered to the scrap winding roller (33).

7. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 5, characterized in that: A tensioning roller (52) is fixedly connected to the front end of the soluble microneedle sheet pasting and unloading platform (5), and the tensioning roller (52) is located obliquely below the guide rod (45). Support rollers (53) are respectively fixedly connected to the front and rear ends of the soluble microneedle sheet pasting and unloading platform (5), and the two support rollers (53) are arranged parallel to the tensioning roller (52). In the step S4, the cut film (10) to be pasted is pulled out from the lower side of the tensioning roller (52) and pasted and tensioned, and one end of the film (10) to be pasted is pulled upward from between the tensioning roller (52) and the support roller (53) and tensioned through the tensioning roller (52), and after being pulled out, it is pulled out and tensioned through the upper side of another tensioning roller (52).

8. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 7, characterized in that: The truss manipulator (7) is provided with two suction plates (71) movable in the front-rear direction, and each suction plate (71) is provided with a plurality of groups of suction heads (72). In the step S4, after the punching base (62), a plurality of pairs of soluble microneedle sheets (9) are punched out, and the suction heads (72) of the two suction plates (71) suck the plurality of pairs of soluble microneedle sheets (9) at intervals. After the sucking, the truss manipulator (7) is moved laterally to move the two suction plates (71) away from each other, and then the soluble microneedle sheets (9) are placed on the inner bonding surface (22a) of the film (10) to be bonded.

9. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 1, 2, or 3, characterized in that: The unloading tray (51) is provided with a plurality of suction holes (51a), and the unloading platform (5) for pasting the soluble microneedle sheet is connected with a cylinder (56). In the step S5, the cylinder (56) is started, and the unloading tray (51) vacuum-adsorbs the waist-shaped sheet (2) onto the upper end surface of the unloading tray (51) through the suction holes (51a) to separate the waist-shaped sheet (2) from the film to be pasted (10), and the cylinder (56) is closed to release the suction of the waist-shaped sheet (2).

10. The method for producing a microneedle patch based on a punching roller cutting, tearing, and pasting integrated machine according to claim 9, characterized in that: A feeding shaft (54) is hingedly connected to the feeding platform (5) for pasting the soluble microneedle sheet, and the front end of the lower end surface of the feeding plate (51) is fixedly connected to the middle part of the feeding shaft (54). In the step S5, the cylinder (56) is closed and the feeding cylinder (55) is started, the feeding cylinder (55) drives the feeding shaft (54) to rotate, and the middle part of the feeding shaft (54) drives the rear end of the feeding plate (51) to flip downward.

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