Current detection method, equipment and system for continuous glucose monitoring devices

Abstract

This disclosure relates to a current detection method, device, and system for a continuous glucose monitoring device. The continuous glucose monitoring device includes an electrochemical sensor and an AFE unit. The current generated by the electrochemical reaction of the electrochemical sensor flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit, and then flows back in through the auxiliary electrode of the electrochemical sensor. The method includes: acquiring the current operating temperature value of the continuous glucose monitoring device; obtaining the bias voltage of the working electrode corresponding to the current operating temperature value as the input voltage of the feedback resistor; obtaining the output voltage of the feedback resistor; and determining the current value generated by the electrochemical reaction of the electrochemical sensor based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor.

Description

TECHNICAL FIELD

[0001] The present disclosure relates to blood glucose monitoring technology, and more particularly, to a current detection method, device and system of a continuous blood glucose monitoring device. BACKGROUND

[0002] In a continuous glucose monitoring (CGM) device, the current generated by the electrochemical reaction of glucose in tissue fluid and active substances on an electrochemical sensor is very small, usually in the order of nA. In the prior art, the calculation of the current value generated by the electrochemical reaction does not consider the influence of temperature, resulting in inaccurate detection of the current value. SUMMARY

[0003] An object of the present application is to provide a new technical solution for a current detection method of a continuous blood glucose monitoring device.

[0004] According to a first aspect of the present application, a current detection method of a continuous blood glucose monitoring device is provided, the continuous blood glucose monitoring device comprising an electrochemical sensor and an AFE unit, the electrochemical sensor generating a current by an electrochemical reaction, the current flowing out of a working electrode of the electrochemical sensor, flowing through a feedback resistor in the AFE unit, and flowing into an auxiliary electrode of the electrochemical sensor, wherein the method comprises: obtaining a current working temperature value of the continuous blood glucose monitoring device;

[0005] According to the current working temperature value, a bias voltage of the working electrode corresponding to the current working temperature value is obtained as an input voltage of the feedback resistor;

[0006] An output voltage of the feedback resistor is obtained;

[0007] According to the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor and the resistance value of the feedback resistor, a current value generated by the electrochemical reaction of the electrochemical sensor is determined.

[0008] Optionally, the cloud server stores bias voltages of working electrodes at different working temperature values of each continuous blood glucose monitoring device, and the bias voltage of the working electrode corresponding to the current working temperature value is obtained according to the current working temperature value, comprising:

[0009] A request for obtaining the bias voltage of the working electrode corresponding to the current working temperature value is sent to the cloud server, wherein the request includes identification information of the continuous blood glucose monitoring device and the current working temperature value of the continuous blood glucose monitoring device;

[0010] The cloud server receives the bias voltage of the working electrode corresponding to the current operating temperature value, wherein the bias voltage of the working electrode corresponding to the current temperature value is determined by the cloud server based on the identification information of the continuous blood glucose monitoring device, the current operating temperature value of the continuous blood glucose monitoring device, and the bias voltage of the working electrode of each continuous blood glucose monitoring device at different operating temperature values.

[0011] Optionally, the continuous glucose monitoring device stores the correspondence between temperature values ​​and bias voltages of the working electrode for different temperature ranges, wherein obtaining the bias voltage of the working electrode corresponding to the current working temperature value includes:

[0012] Based on the correspondence between the current operating temperature value, the temperature values ​​corresponding to different temperature ranges, and the bias voltage of the working electrode, determine the correspondence between the temperature value corresponding to the current operating temperature value and the bias voltage of the working electrode.

[0013] Based on the current operating temperature value, the corresponding temperature value, and the bias voltage of the working electrode, the bias voltage of the working electrode corresponding to the current operating temperature value is determined.

[0014] Optionally, the correspondence between the temperature values ​​corresponding to different temperature ranges and the bias voltage of the working electrode is obtained from the cloud server and determined by the cloud server based on the bias voltage of the working electrode corresponding to different temperature values.

[0015] Optionally, the bias voltage of the working electrode corresponding to different temperature values ​​is obtained by embedding the continuous blood glucose monitoring device in a variable temperature chamber and measuring it with a multimeter.

[0016] Optionally, the continuous glucose monitoring device further includes a temperature sensor, wherein acquiring the current operating temperature value of the continuous glucose monitoring device includes:

[0017] The temperature value collected by the temperature sensor is obtained as the current operating temperature value of the continuous monitoring device.

[0018] Optionally, the method further includes: obtaining the theoretical bias voltage and the actual bias voltage of the working electrode, wherein the actual bias voltage of the working electrode is determined by the AFE unit based on the DAC value obtained from the cloud server;

[0019] If the difference between the theoretical bias voltage and the actual bias voltage of the working electrode exceeds a preset threshold, it is determined that the AFE unit is abnormal.

[0020] If the AFE unit is found to be malfunctioning, the continuous blood glucose monitoring device is also found to be malfunctioning.

[0021] According to a second aspect of the present invention, a continuous blood glucose monitoring device is provided, comprising: an electrochemical sensor, an AFE unit, and a control unit, wherein the current generated by the electrochemical sensor through an electrochemical reaction flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit, and then flows in through the auxiliary electrode of the electrochemical sensor;

[0022] The control unit is used to acquire the current operating temperature value of the continuous glucose monitoring device; based on the current operating temperature value, obtain the bias voltage of the working electrode corresponding to the current operating temperature value, as the input voltage of the feedback resistor; acquire the output voltage of the feedback resistor; and determine the current value generated by the electrochemical reaction of the electrochemical sensor based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor.

[0023] Optionally, the device further includes a temperature sensor for detecting the current operating temperature value of the continuous monitoring device.

[0024] According to a third aspect of the present invention, a continuous glucose monitoring system is provided, comprising: a continuous glucose monitoring device as described in the second aspect, a terminal device, and a cloud server, wherein...

[0025] The continuous glucose monitoring device establishes a communication connection with the terminal device, the terminal device establishes a communication connection with the cloud server, and the terminal device has an APP corresponding to continuous glucose monitoring installed.

[0026] The current detection method for a continuous blood glucose monitoring device provided by this invention obtains the bias voltage of the working electrode corresponding to the current working temperature value, which is used as the input voltage of the feedback resistor, taking into account the influence of temperature. Then, based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor, the current value generated by the electrochemical reaction of the electrochemical sensor is determined, which improves the accuracy of current detection and thus improves the accuracy of blood glucose detection.

[0027] The features and advantages of the embodiments of this specification will become clear from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0028] The accompanying drawings, which are incorporated in and form a part of this specification, illustrate embodiments of this specification and, together with their description, serve to explain the principles of these embodiments.

[0029] Figure 1This is a schematic diagram of a continuous blood glucose monitoring system according to an embodiment of the present invention.

[0030] Figure 2 This is a schematic flowchart of a current detection method for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0031] Figure 3 This is a flowchart illustrating a specific method for measuring the bias voltage of the working electrode at different temperature values ​​according to an embodiment of the present invention.

[0032] Figure 4 This is a schematic flowchart of a current detection method for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0033] Figure 5 This is a schematic flowchart of a current detection method for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0034] Figure 6 This is a schematic diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention. Detailed Implementation

[0035] Various exemplary embodiments of this specification will now be described in detail with reference to the accompanying drawings.

[0036] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the embodiments of this specification or their application or use.

[0037] It should be noted that similar labels and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be discussed further in subsequent figures.

[0038] In one embodiment of the present invention, a current detection method for a continuous glucose monitoring device is provided. This method is applied to a continuous glucose monitoring device.

[0039] according to Figure 1 As shown, the continuous glucose monitoring device establishes a communication connection with the terminal device. This communication connection is wireless, such as via Bluetooth or Wi-Fi. The terminal device has a corresponding app installed. The continuous glucose monitoring device interacts with the cloud server through this app. For example, the continuous glucose monitoring device sends its monitored blood glucose values ​​to the cloud server through the app, and the cloud server sends pre-stored device parameters to the corresponding continuous glucose monitoring device through the app.

[0040] Continuous glucose monitoring devices consist of an electrochemical sensor and an AFE (Active Front End) unit. The electrochemical sensor has a three-electrode structure: a working electrode, a reference electrode, and an auxiliary electrode. Glucose from the tissue fluid extracted by the extraction electrode reacts electrochemically with the enzymes in the electrochemical sensor. The current generated by this electrochemical reaction flows out through the working electrode of the electrochemical sensor, through the feedback resistor in the AFE unit, and then back into the device through the auxiliary electrode.

[0041] according to Figure 2 As shown, the current detection method of the continuous blood glucose monitoring device in this embodiment includes the following steps S210 to S230.

[0042] Step S210: Obtain the current operating temperature value of the continuous blood glucose monitoring device.

[0043] In some embodiments, the continuous glucose monitoring device is equipped with a temperature sensor. The current operating temperature of the continuous glucose monitoring device is determined based on the temperature value collected by the temperature sensor. This temperature sensor may be an NTC (Negative Temperature Coefficient Sensor).

[0044] Step S220: Based on the current operating temperature value, obtain the bias voltage of the working electrode corresponding to the current operating temperature value, and use it as the input voltage of the feedback resistor.

[0045] The bias voltage of the working electrode is a voltage used to ensure the normal operation of the electrochemical sensor, and it is susceptible to temperature. Therefore, the influence of temperature needs to be considered in this embodiment.

[0046] In some embodiments, the cloud server stores the bias voltages of the working electrodes of each continuous glucose monitoring device at different operating temperatures. Step S220 specifically includes: sending a request to the cloud server to obtain the bias voltage of the working electrode corresponding to the current operating temperature, wherein the request includes the identification information of the continuous glucose monitoring device and the current operating temperature value of the continuous glucose monitoring device; receiving the bias voltage of the working electrode corresponding to the current operating temperature value returned by the cloud server, wherein the bias voltage of the working electrode corresponding to the current temperature value is determined by the cloud server based on the identification information of the continuous glucose monitoring device, the current operating temperature value of the continuous glucose monitoring device, and the bias voltages of the working electrodes of each continuous glucose monitoring device at different operating temperatures.

[0047] The continuous glucose monitoring (CGM) device sends a request to the terminal device to obtain the bias voltage of the working electrode corresponding to the current operating temperature. The terminal device has a corresponding CGM app installed. The terminal device sends this request to the cloud server corresponding to the CGM app. Based on the identification information of the CGM device in the request, the cloud server obtains the bias voltage of the working electrode corresponding to different operating temperatures. Then, based on the current operating temperature in the request and the obtained bias voltages of the working electrode corresponding to different operating temperatures, the cloud server determines the bias voltage of the working electrode corresponding to the current operating temperature of the CGM device.

[0048] The identification information of the continuous glucose monitoring device included in the request is the identity information of the continuous glucose monitoring device, which can be the Bluetooth address information of the continuous glucose monitoring device.

[0049] The method for obtaining the bias voltage of the working electrode corresponding to the current operating temperature provided in this embodiment is applicable to continuous glucose monitoring devices that can interact with a cloud server via a terminal device equipped with a corresponding continuous glucose monitoring app. This eliminates the need for the continuous glucose monitoring device to store the bias voltage of the working electrode at different temperatures, reducing storage capacity requirements and consequently lowering the device's manufacturing cost.

[0050] In some embodiments, the continuous glucose monitoring device stores the correspondence between temperature values ​​and bias voltages of the working electrode for different temperature ranges. Step S120 specifically includes: determining the correspondence between the temperature value corresponding to the current operating temperature and the bias voltage of the working electrode based on the current operating temperature value and the correspondence between temperature values ​​and bias voltages of the working electrode for different temperature ranges; and determining the bias voltage of the working electrode corresponding to the current operating temperature based on the current operating temperature value and the correspondence between temperature values ​​and bias voltages of the working electrode for the current operating temperature.

[0051] The relationship between the temperature values ​​corresponding to different temperature ranges and the bias voltage of the working electrode is obtained from the cloud server and determined by the cloud server based on the bias voltage of the working electrode corresponding to different temperature values.

[0052] For example, a continuous glucose monitoring device (CGM) stores the correspondence between temperature values ​​and the bias voltage of the working electrode for three different temperature ranges: (10℃, 20℃), (20℃, 30℃), and (30℃, 40℃). If the current operating temperature of the CGM is 25℃, the correspondence between the temperature value and the bias voltage of the working electrode at the current operating temperature of 25℃ is determined to be the correspondence between the temperature value and the bias voltage of the working electrode at the current operating temperature of 25℃ and the current operating temperature of 30℃. Then, based on the correspondence between the temperature value and the bias voltage of the working electrode at the current operating temperature of 25℃ and the current operating temperature of 30℃, the CGM determines the bias voltage of the working electrode at the current operating temperature of 25℃.

[0053] The method for obtaining the bias voltage of the working electrode corresponding to the current operating temperature provided in this embodiment is applied when the continuous blood glucose monitoring device cannot interact with the cloud server through a terminal device with a corresponding continuous blood glucose monitoring APP. This ensures that current detection can still be achieved even when the continuous blood glucose monitoring device cannot interact with the cloud server. Furthermore, the continuous blood glucose monitoring device only stores the correspondence between temperature values ​​and the bias voltage of the working electrode for different temperature ranges, thus saving storage resources.

[0054] Step S230: Obtain the output voltage of the feedback resistor.

[0055] The output voltage of the feedback resistor is directly acquired by the AFE unit.

[0056] Step S240: Determine the current value generated by the electrochemical reaction of the electrochemical sensor based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor.

[0057] Based on the bias voltage of the working electrode corresponding to the current temperature and the output voltage of the feedback resistor, the voltage across the feedback resistor is calculated. Then, based on the voltage across the feedback resistor and the resistance of the feedback resistor, the current generated by the electrochemical reaction of the electrochemical sensor is determined. Specifically, the current generated by the electrochemical reaction of the electrochemical sensor is determined based on the following formula:

[0058]

[0059] Where U1 is the bias voltage of the working electrode corresponding to the current temperature value, U2 is the output voltage of the feedback resistor, and R is the resistance value of the feedback resistor.

[0060] After determining the current value generated by the electrochemical reaction of the chemical sensor, the continuous glucose monitoring device determines the corresponding blood glucose value based on the current value.

[0061] The bias voltage of the working electrode is a voltage used to ensure the normal operation of the electrochemical sensor and is susceptible to temperature fluctuations. The current detection method for a continuous glucose monitoring device provided by this invention obtains the bias voltage of the working electrode corresponding to the current operating temperature, using it as the input voltage of the feedback resistor. This takes temperature into account. Then, based on the bias voltage of the working electrode corresponding to the current temperature, the output voltage of the feedback resistor, and the resistance value of the feedback resistor, the current value generated by the electrochemical reaction of the electrochemical sensor is determined, improving the accuracy of current detection and thus improving the accuracy of glucose detection.

[0062] In some embodiments, the bias voltage of the working electrode corresponding to different temperature values ​​is measured using a multimeter by embedding the continuous glucose monitoring device within a variable temperature chamber. It should be noted that the measurement of the bias voltage of the working electrode corresponding to different temperature values ​​is performed before the continuous glucose monitoring device leaves the factory.

[0063] according to Figure 3 As shown, the specific measurement method for the bias voltage of the working electrode corresponding to different temperature values ​​includes the following steps S310 to S340.

[0064] Step S310: Place the continuous blood glucose monitoring device in a variable temperature chamber, and place a multimeter in the variable temperature chamber to collect the bias voltage of the continuous blood glucose monitoring device.

[0065] In step S320, within the preset operating temperature range of the continuous blood glucose monitoring device, the temperature of the variable temperature chamber is adjusted in 1°C increments. The multimeter transmits the bias voltage of the continuous blood glucose monitoring device collected at different temperatures to the terminal device. This terminal device is equipped with a continuous blood glucose monitoring app.

[0066] In step S330, the terminal device obtains the identification information of the continuous blood glucose monitoring device placed in the variable temperature box.

[0067] In step S340, the terminal device will obtain the identification information of the continuous blood glucose monitoring device and the corresponding bias voltage of the continuous blood glucose monitoring device at different temperatures, and send them to the cloud server corresponding to the continuous blood glucose monitoring APP.

[0068] In some embodiments, the method further includes: obtaining the theoretical bias voltage and the actual bias voltage of the working electrode, wherein the actual bias voltage of the working electrode is determined by the AFE unit based on the DAC value obtained from a cloud server; determining that the AFE unit is abnormal if the difference between the theoretical bias voltage and the actual bias voltage of the working electrode exceeds a preset threshold; determining that the continuous glucose monitoring device is abnormal if the AFE unit is determined to be abnormal, and step S210 is not executed. If the difference between the theoretical bias voltage and the actual bias voltage of the working electrode does not exceed the preset threshold, determining that the AFE unit is not abnormal, and then executing step S210. This allows for timely detection of whether the AFE unit is abnormal when the continuous glucose monitoring device is started, thereby ensuring the readiness of current detection.

[0069] The theoretical bias voltage of the working electrode is pre-stored in the continuous glucose monitoring device.

[0070] The DAC value obtained from the cloud server is determined by the AFE unit based on the bias voltage of the working electrode measured by a multimeter before the continuous glucose monitoring device leaves the factory.

[0071] Figure 4 This is a schematic flowchart of a current detection method for a continuous glucose monitoring device according to an embodiment of the present invention. Figure 4 As shown, the method includes the following steps S410 to S490.

[0072] Step S410: The continuous blood glucose monitoring device obtains the current operating temperature value.

[0073] In step S420, the continuous glucose monitoring device sends a request to the terminal device via Bluetooth to obtain the bias voltage of the working electrode corresponding to the current operating temperature value. The request includes the identification information of the continuous glucose monitoring device and the current operating temperature value of the continuous glucose monitoring device.

[0074] In step S430, the terminal device sends the obtained acquisition request to the cloud server corresponding to the APP for continuous blood glucose monitoring.

[0075] In step S440, the cloud server obtains the bias voltage of the working electrode corresponding to different temperature values ​​based on the identification information of the continuous blood glucose monitoring device in the acquisition request.

[0076] In step S450, the cloud server determines the bias voltage of the working electrode corresponding to the current operating temperature value of the continuous blood glucose monitoring device based on the current operating temperature value and the bias voltage of the working electrode corresponding to different temperature values ​​in the acquisition request.

[0077] In step S460, the cloud server sends the bias voltage of the working electrode corresponding to the current operating temperature value of the continuous blood glucose monitoring device to the terminal device.

[0078] In step S470, the terminal device sends the bias voltage of the working electrode corresponding to the received current operating temperature value to the corresponding continuous blood glucose monitoring device.

[0079] In step S480, the continuous blood glucose monitoring device obtains the output voltage of the feedback resistor.

[0080] In step S490, the continuous blood glucose monitoring device determines the current value generated by the electrochemical reaction of the electrochemical sensor based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor.

[0081] Figure 5 This is a schematic flowchart of a current detection method for a continuous glucose monitoring device according to an embodiment of the present invention. Figure 5 As shown, the method includes the following steps S510 to S550.

[0082] Step S510: The continuous blood glucose monitoring device obtains the current operating temperature value, the corresponding temperature values ​​for different temperature ranges, and the corresponding relationship between the bias voltage of the working electrode.

[0083] Step S520: The continuous blood glucose monitoring device determines the correspondence between the current operating temperature value and the bias voltage of the working electrode based on the current operating temperature value, the corresponding temperature values ​​for different temperature ranges, and the bias voltage of the working electrode.

[0084] In step S530, the continuous blood glucose monitoring device determines the bias voltage of the working electrode corresponding to the current working temperature value based on the current working temperature value and the corresponding relationship between the temperature value corresponding to the current working temperature value and the bias voltage of the working electrode.

[0085] In step S540, the continuous blood glucose monitoring device obtains the output voltage of the feedback resistor.

[0086] In step S550, the continuous blood glucose monitoring device determines the current value generated by the electrochemical reaction of the electrochemical sensor based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor.

[0087] One embodiment of the present invention provides a continuous glucose monitoring device. According to... Figure 6As shown, the continuous glucose monitoring device includes an electrochemical sensor, an AFE unit, and a control unit. The current generated by the electrochemical reaction in the electrochemical sensor flows out through the working electrode of the electrochemical sensor, passes through the feedback resistor in the AFE unit, and then flows back in through the auxiliary electrode of the electrochemical sensor.

[0088] The control unit is used to acquire the current operating temperature value of the continuous glucose monitoring device; based on the current operating temperature value, it obtains the bias voltage of the working electrode corresponding to the current operating temperature value, which is used as the input voltage of the feedback resistor; it obtains the output voltage of the feedback resistor; and based on the bias voltage of the working electrode corresponding to the current temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor, it determines the current value generated by the electrochemical reaction of the electrochemical sensor.

[0089] The control unit is an MCU (Microcontroller Unit).

[0090] according to Figure 6 As shown, the continuous glucose monitoring device also includes extraction electrodes and a temperature sensor. The extraction electrodes are used to extract tissue fluid, allowing the glucose in the tissue fluid to undergo an electrochemical reaction with the electrochemical sensor. The temperature sensor is used to detect the current operating temperature of the continuous monitoring device.

[0091] One embodiment of the present invention provides a continuous blood glucose monitoring system. According to... Figure 1 As shown, the system includes a continuous glucose monitoring device, a terminal device, and a cloud server. The continuous glucose monitoring device establishes a communication connection with the terminal device, and the terminal device establishes a communication connection with the cloud server. The terminal device has a corresponding APP for continuous glucose monitoring installed.

[0092] Continuous glucose monitoring (CGM) devices interact with the cloud server via this app. For example, the CGM device sends its monitored blood glucose value to the cloud server through the app, and the cloud server sends pre-stored device parameters to the corresponding CGM device through the app. By storing and processing data on the cloud server, data integration and intelligent management are achieved, facilitating the analysis and optimization of large amounts of device and user data, and further enhancing the intelligence level of the monitoring system.

[0093] The various embodiments in this specification are described in a progressive manner. The same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on describing the differences from other embodiments.

[0094] The foregoing has described specific embodiments of this specification. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims may be performed in a different order than that shown in the embodiments and may still achieve the desired result. Furthermore, the processes depicted in the drawings do not necessarily require the specific or sequential order shown to achieve the desired result. In some embodiments, multitasking and parallel processing are possible or may be advantageous.

[0095] Embodiments of this specification may be systems, methods, and / or computer program products. A computer program product may include a computer-readable storage medium having computer instructions stored thereon for causing a processor to implement various aspects of the embodiments of this specification.

[0096] Computer-readable storage media can be tangible devices capable of holding and storing computer instructions for use by computer instruction execution devices. Computer-readable storage media can be, for example—but not limited to—electrical storage devices, magnetic storage devices, optical storage devices, electromagnetic storage devices, semiconductor storage devices, or any suitable combination thereof. More specific examples (a non-exhaustive list) of computer-readable storage media include: portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), static random access memory (SRAM), portable compact disc read-only memory (CD-ROM), digital multifunction disc (DVD), memory sticks, floppy disks, mechanical encoding devices, such as punch cards or recessed protrusions storing computer instructions thereon, and any suitable combination thereof. The computer-readable storage media used herein are not to be construed as transient signals themselves, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through waveguides or other transmission media (e.g., light pulses through fiber optic cables), or electrical signals transmitted through wires.

[0097] The computer instructions described herein can be downloaded from computer-readable storage media to various computing / processing devices, or downloaded via a network, such as the Internet, local area network, wide area network, and / or wireless network, to an external computer or external storage device. The network may include copper cables, fiber optic cables, wireless transmission, routers, firewalls, switches, gateway computers, and / or edge servers. A network adapter card or network interface in each computing / processing device receives computer instructions from the network and forwards them to computer-readable storage media within the respective computing / processing device.

[0098] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of this specification. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of computer instructions, which contains one or more executable computer instructions for implementing a specified logical function. In some alternative implementations, the functions indicated in the blocks may occur in a different order than those indicated in the drawings. For example, two consecutive blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, may be implemented using a dedicated hardware-based system that performs the specified function or action, or using a combination of dedicated hardware and computer instructions. It will be known to those skilled in the art that implementation in hardware, implementation in software, and implementation using a combination of software and hardware are equivalent.

[0099] Various embodiments of this specification have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A current detection method of a continuous glucose monitoring device, characterized in that, The continuous glucose monitoring device comprises an electrochemical sensor, an AFE unit, a feedback resistor, and a cloud server. The electrochemical sensor generates an electric current through a working electrode, the feedback resistor, and an auxiliary electrode. The cloud server stores bias voltages of the working electrode at different working temperature values of the continuous glucose monitoring device. The method comprises the following steps. The method comprises the following steps. According to the current working temperature value, the bias voltage of the working electrode corresponding to the current working temperature value is obtained as the input voltage of the feedback resistor, comprising the following steps. The output voltage of the feedback resistor is obtained. According to the bias voltage of the working electrode corresponding to the current working temperature value, the output voltage of the feedback resistor, and the resistance value of the feedback resistor, the current value generated by the electrochemical reaction of the electrochemical sensor is determined.

2. The method of claim 1, wherein, The continuous glucose monitoring device stores a corresponding relationship between temperature values and bias voltages of working electrodes corresponding to different temperature ranges. According to the current working temperature value, the bias voltage of the working electrode corresponding to the current working temperature value is obtained, comprising the following steps. According to the current working temperature value, the corresponding relationship between the temperature value and the bias voltage of the working electrode corresponding to the current working temperature value is determined. According to the current working temperature value, the corresponding relationship between the temperature value and the bias voltage of the working electrode corresponding to the current working temperature value is determined.

3. The method of claim 2, wherein, The corresponding relationship between the temperature value and the bias voltage of the working electrode corresponding to the different temperature ranges is obtained from the cloud server and determined by the cloud server based on the bias voltage of the working electrode corresponding to different temperature values.

4. The method of claim 1, wherein, The bias voltage of the working electrode at different working temperature values is obtained by placing the corresponding continuous glucose monitoring device in a temperature chamber and using a multimeter.

5. The method of claim 1, wherein, The continuous glucose monitoring device further comprises a temperature sensor. The current working temperature value of the continuous glucose monitoring device is obtained, comprising the following steps. The temperature value collected by the temperature sensor is obtained as the current working temperature value of the continuous glucose monitoring device.

6. The method according to any one of claims 1 to 5, characterized in that, The method further comprises the following steps. obtain a theoretical bias voltage of a working electrode and an actual bias voltage of the working electrode, the actual bias voltage of the working electrode being determined by the AFE unit based on a DAC value obtained from a cloud server; in a case where a difference between the theoretical bias voltage of the working electrode and the actual bias voltage of the working electrode exceeds a preset threshold value, determine that the AFE unit is abnormal; in a case where it is determined that the AFE unit is abnormal, determine that the continuous glucose monitoring device is abnormal.

7. A continuous glucose monitoring device, characterized by, The continuous glucose monitoring device comprises an electrochemical sensor, an AFE unit, a control unit, a working electrode of the electrochemical sensor, a feedback resistor in the AFE unit, and an auxiliary electrode of the electrochemical sensor, and a cloud server storing bias voltages of the working electrode at different working temperature values of each continuous glucose monitoring device; The control unit is configured to obtain a current working temperature value of the continuous glucose monitoring device; According to the current working temperature value, the bias voltage of the working electrode corresponding to the current working temperature value is obtained as the input voltage of the feedback resistor, specifically including: sending a request for obtaining the bias voltage of the working electrode corresponding to the current working temperature value to the cloud server, wherein the request includes the identification information of the continuous glucose monitoring device and the current working temperature value of the continuous glucose monitoring device, receiving the bias voltage of the working electrode corresponding to the current working temperature value returned by the cloud server, wherein the bias voltage of the working electrode corresponding to the current working temperature value is determined by the cloud server based on the identification information of the continuous glucose monitoring device, the current working temperature value of the continuous glucose monitoring device, and the bias voltages of the working electrode at different working temperature values of each continuous glucose monitoring device; obtaining the output voltage of the feedback resistor; and determining the current value of the current generated by the electrochemical reaction of the electrochemical sensor according to the bias voltage of the working electrode corresponding to the current working temperature value, the output voltage of the feedback resistor and the resistance value of the feedback resistor.

8. The continuous glucose monitoring device of claim 7, wherein, The device further comprises a temperature sensor for detecting the current working temperature value of the continuous glucose monitoring device.

9. A continuous glucose monitoring system, characterized in that, Comprise: The continuous glucose monitoring device, the terminal device and the cloud server of claim 7 or 8, wherein, The continuous glucose monitoring device and the terminal device establish a communication connection, the terminal device and the cloud server establish a communication connection, and the terminal device is installed with a continuous glucose monitoring corresponding APP.

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