Mild exfoliating whitening and repairing body care composition as well as preparation method and application thereof

Abstract

The invention relates to a mild exfoliating whitening and repairing body care composition as well as a preparation method and application thereof. The mild exfoliating whitening and repairing body care composition is prepared from the following components in parts by weight: 5 to 10 parts of lipidosome, 0.01 to 1 part of papain and 0.005 to 0.5 part of bromelain, wherein the liposome comprises a shell layer and a core layer, the shell layer comprises lecithin and phytosterol, and the core layer comprises a golden camellia extract and hydrolyzed royal jelly protein; the liposome is prepared from the following raw materials in parts by weight: 2 to 15 parts of lecithin, 0.1 to 5 parts of phytosterol, 0.1 to 3 parts of golden camellia extract and 0.01 to 1 part of hydrolyzed royal jelly protein. The composition can realize multiple effects of brightening skin color, removing waste cutin and strengthening skin, and is safe, mild and non-irritant.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a mild exfoliating, whitening and repairing body care composition, a preparation method and application thereof. Background Art

[0002] The skin on the hands often faces problems such as pigmentation, roughness, and aging due to exposure to the external environment (such as ultraviolet rays, air pollution, etc.). Especially as we age, the water loss and collagen reduction of the skin on the hands are prone to wrinkles and dullness, affecting the overall appearance of the skin.

[0003] There are many hand cream products on the market that aim to improve the skin quality of the hands, but most products have the problem of single efficacy and slow effect. There is also the limitation that they cannot effectively solve multiple needs such as brightening the skin tone, removing old keratin and strengthening the skin at the same time. The existing technology often focuses on one aspect of care, such as whitening or repairing, but lacks a comprehensive effect, and the ingredients in many products may cause skin irritation or discomfort, affecting the consumer's experience. Therefore, the development of a multi-effect hand cream that can brighten the skin tone, remove old keratin and strengthen the skin has a wide market demand and can fill the gaps in the multiple functions of existing products. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a mild exfoliating, whitening and repairing body care composition and a preparation method and application thereof.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] In a first aspect, the present invention provides a mild exfoliating, whitening and repairing body care composition, composed of the following components in parts by weight: 5-10 parts of liposomes, 0.01-1 parts of papain and 0.005-0.5 parts of bromelain; wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes camellia chrysantha extract and hydrolyzed royal jelly protein; the liposomes include the following raw materials in parts by weight: 2-15 parts of lecithin, 0.1-5 parts of phytosterols, 0.1-3 parts of camellia chrysantha extract, and 0.01-1 parts of hydrolyzed royal jelly protein.

[0007] The main components of the mild exfoliating whitening and repairing body care composition are liposomes, papain and bromelain, wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes golden camellia extract and hydrolyzed royal jelly protein. Specifically, the lecithin is a natural phospholipid rich in phosphatidylcholine, which can enhance the repair ability of skin cells and reduce dryness and sagging of the skin caused by aging; the phytosterols are a class of natural ingredients derived from plants, which have a structure similar to cholesterol, have antioxidant and anti-inflammatory effects, can relieve skin oxidative stress and inflammatory aging, and at the same time act as the outer shell of the liposome to stabilize the liposome and promote the release of the liposome in the deep layers of the skin; the golden camellia extract is rich in flavonoids and polysaccharide compounds, has strong antioxidant and anti-inflammatory effects, and can inhibit tyrosinase activity and scavenge free radicals. The effects of whitening and skin protection are achieved; the hydrolyzed royal jelly protein is obtained by hydrolyzing royal jelly protein into a product with a smaller molecular weight using protease, and is a high-nutrient substance that can be absorbed by the skin, and can promote skin repair and regeneration; the papain is a plant enzyme extracted from papaya, and has the effects of mildly exfoliating and promoting cell renewal; the bromelain is a plant enzyme extracted from pineapple, and can deeply decompose the protein in the stratum corneum, making the skin more delicate and smooth. The combination of the two can take into account the exfoliation needs of different depths, and at the same time, the removal of waste keratin can promote the skin absorption and utilization of other active ingredients.

[0008] There are three reasons for encapsulating camellia chrysantha extract and hydrolyzed royal jelly protein in liposomes, namely: 1. Camellia chrysantha extract is rich in flavonoids and polysaccharide compounds, which will affect the activity of papain and bromelain, so the camellia chrysantha extract should be separated from the two proteases; 2. Hydrolyzed royal jelly protein will also be decomposed by papain and bromelain, resulting in reduced activity, so the hydrolyzed royal jelly protein and the two proteases should be separated; 3. Papain and bromelain work on the surface of the skin, and after removing the waste stratum corneum, they can promote the skin absorption of camellia chrysantha extract and hydrolyzed royal jelly protein, and using liposomes to encapsulate camellia chrysantha extract and hydrolyzed royal jelly protein can prevent them from reacting with proteases while further promoting the two to penetrate deep into the skin to work.

[0009] Preferably, the weight ratio of the Camellia chrysantha extract to the hydrolyzed royal jelly protein is (1.5-3.5):1.

[0010] More preferably, the weight ratio of the Camellia chrysantha extract to the hydrolyzed royal jelly protein is (2-3):1.

[0011] Preferably, the mass ratio of the liposome, papain and bromelain is 80:(1-5):(0.5-3).

[0012] More preferably, the mass ratio of the liposome, papain and bromelain is 80:(2-3):(1-2).

[0013] Specifically, the method for preparing the liposome comprises the following steps:

[0014] (1) adding lecithin and phytosterol to an ethanol solution, mixing them evenly, and removing the ethanol to obtain a lipid film;

[0015] (2) The camellia chrysantha extract and the hydrolyzed royal jelly protein are mixed evenly, added to the lipid film, heated at 40-60° C. and stirred evenly, and then homogenized to obtain the product, and then the unencapsulated components are filtered out to obtain the liposome encapsulating the camellia chrysantha extract and the hydrolyzed royal jelly protein.

[0016] Preferably, in step (1) of the liposome preparation method, the mass concentration of the ethanol solution is 70-80%.

[0017] Preferably, in step (2) of the liposome preparation method, the homogenization pressure is 500-800 bar, the homogenization speed is 1000-2000 rpm, and the homogenization time is 3-5 min.

[0018] Specifically, the preparation method of the mild exfoliating whitening and repairing body care composition comprises the following steps:

[0019] After the liposomes, papain and bromelain are mixed, they are stirred at a rotation speed of 300-500 r / min for 10-20 min to obtain the body care composition.

[0020] In a second aspect, the present invention provides use of the mild exfoliating, whitening and repairing body care composition described in the first aspect in the preparation of skin care products.

[0021] In a third aspect, the present invention provides a hand cream according to the second aspect, comprising the following raw materials in weight percentage: 5%-20% of a mild exfoliating whitening and repairing body care composition, 0.1%-0.3% of a thickener, 4%-6% of a moisturizer, 10-13% of an emulsifier, 1%-1.5% of a preservative and 0.1%-0.2% of a pH regulator, with the remainder being deionized water.

[0022] Preferably, the thickener includes at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol.

[0023] Preferably, the moisturizing agent includes at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butylene glycol, glycerol, budding pullulan polysaccharide, and ceramide.

[0024] Preferably, the emulsifier includes at least one of dimethicone, cetearyl alcohol, caprylic / capric triglyceride, glyceryl stearate citrate and PEG-100 stearate.

[0025] Preferably, the preservative includes at least one of 1,2-propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone.

[0026] Preferably, the pH adjuster comprises at least one of arginine, tromethamine, and EDTA-disodium.

[0027] In a fourth aspect, the present invention provides a method for preparing the hand cream in the third aspect, comprising the following steps:

[0028] S1. After the humectant, thickener and part of deionized water are mixed evenly, they are homogenized at 75-85°C to form a uniform aqueous phase, the emulsifier is mixed evenly at 80-90°C, and the aqueous phase and the emulsifier are mixed evenly at 75-85°C to obtain a mixture;

[0029] S2. Add the preservative to the mixture obtained in step S1 and stir evenly. After the temperature drops to 35-45° C., add the body care composition and the remaining deionized water and stir evenly. Finally, add a pH adjuster to adjust the pH to obtain the hand cream.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] The main components of the composition of the present invention are papain, bromelain and a liposome containing a shell composed of lecithin and phytosterols and encapsulating a golden camellia extract and hydrolyzed royal jelly protein. Both papain and bromelain are plant enzymes, and the two are used in combination to take into account the exfoliation requirements of different depths and effectively remove the waste stratum corneum. The golden camellia extract is rich in flavonoids and polysaccharide compounds, and has a strong antioxidant and anti-inflammatory effect, thereby achieving a whitening effect. Lecithin and phytosterols can play a repairing effect, and at the same time, as a liposome shell, they play a role in stabilizing the liposome and promoting the release of the liposome in the deep layer of the skin, which is conducive to the absorption and utilization of other active ingredients. Hydrolyzed royal jelly protein is a high-nutrient substance that can be absorbed by the skin, which can promote the repair and regeneration of the skin and accelerate the recovery of the skin to a healthy state. In addition, the golden camellia extract and the hydrolyzed royal jelly protein are encapsulated in the liposome, which can prevent them from reacting with papain and bromelain to affect the activity, and can also promote them to penetrate into the deep layer of the skin to play a role, further enhancing the whitening and repairing effects. Therefore, these ingredients work synergistically to achieve the multiple benefits of gentle exfoliation, whitening and repairing. DETAILED DESCRIPTION

[0032] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0033] The sources of materials used in the following examples and comparative examples are as follows:

[0034] Lecithin: manufacturer is Shaanxi Denis Biotechnology Co., Ltd., model number is DNS-2023021302;

[0035] Phytosterols: manufacturer is Shaanxi Denis Biotechnology Co., Ltd., model number is DNS-2023081102;

[0036] Camellia chrysantha extract: the manufacturer is Ximuyuan (Xiamen) Biotechnology Co., Ltd., the model is Camellia chrysantha extract;

[0037] Hydrolyzed royal jelly protein: the manufacturer is Japan Katakura & Co-op Agri, the model is ROYALBIOCYTE;

[0038] Papain: manufacturer is Shaanxi Denis Biotechnology Co., Ltd., model number is DNS-2023031503;

[0039] Bromelain: manufacturer is Shanxi Yirun Biotechnology Co., Ltd., model number is 2024112108;

[0040] Unless otherwise specified, other materials, reagents, etc. used in the application examples, comparative application examples, embodiments and comparative examples can be obtained from commercial channels.

[0041] Example 1

[0042] A mild exfoliating, whitening and repairing body care composition is composed of the following components in parts by weight: 8 parts of liposomes, 0.3 parts of papain and 0.2 parts of bromelain; wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes camellia chrysantha extract and hydrolyzed royal jelly protein; the liposomes include the following raw materials in parts by weight: 6 parts of lecithin, 1 part of phytosterols, 0.7 parts of camellia chrysantha extract, and 0.3 parts of hydrolyzed royal jelly protein.

[0043] Wherein, the preparation method of the liposome comprises the following steps:

[0044] (1) adding lecithin and phytosterol to an ethanol solution with a mass concentration of 75%, mixing them evenly, and removing the ethanol to obtain a lipid film;

[0045] (2) The camellia chrysantha extract and the hydrolyzed royal jelly protein are mixed evenly, added to the lipid film, heated and stirred evenly at 50° C., and then homogenized for 10 minutes under the conditions of a pressure of 600 bar and a rotation speed of 1500 rpm to obtain the product, and then the unencapsulated components are filtered out to obtain the liposome encapsulating the camellia chrysantha extract and the hydrolyzed royal jelly protein.

[0046] The preparation method of the whitening and repairing body care composition with mild exfoliation comprises the following steps:

[0047] After the liposomes, papain and bromelain were mixed, the mixture was stirred at a rotation speed of 400 r / min for 15 minutes to obtain the body care composition.

[0048] Example 2

[0049] A mild exfoliating, whitening and repairing body care composition is composed of the following components in parts by weight: 5 parts of liposomes, 0.01 parts of papain and 0.005 parts of bromelain; wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes camellia chrysantha extract and hydrolyzed royal jelly protein; the liposomes include the following raw materials in parts by weight: 2 parts of lecithin, 0.1 parts of phytosterols, 0.1 parts of camellia chrysantha extract, and 0.01 parts of hydrolyzed royal jelly protein.

[0050] Wherein, the preparation method of the liposome comprises the following steps:

[0051] (1) adding lecithin and phytosterol to an ethanol solution with a mass concentration of 70%, mixing them evenly, and removing the ethanol to obtain a lipid film;

[0052] (2) The camellia chrysantha extract and the hydrolyzed royal jelly protein are mixed evenly, added to the lipid film, heated and stirred evenly at 40° C., and then homogenized for 30 minutes under the conditions of a pressure of 500 bar and a rotation speed of 1000 rpm to obtain the product, and then the unencapsulated components are filtered out to obtain the liposome encapsulating the camellia chrysantha extract and the hydrolyzed royal jelly protein.

[0053] The preparation method of the whitening and repairing body care composition with mild exfoliation comprises the following steps:

[0054] After the liposomes, papain and bromelain were mixed, the mixture was stirred at a rotation speed of 300 r / min for 20 minutes to obtain the body care composition.

[0055] Example 3

[0056] A mild exfoliating, whitening and repairing body care composition is composed of the following components in parts by weight: 10 parts of liposomes, 1 part of papain and 0.5 parts of bromelain; wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes camellia chrysantha extract and hydrolyzed royal jelly protein; the liposomes include the following raw materials in parts by weight: 15 parts of lecithin, 5 parts of phytosterols, 3 parts of camellia chrysantha extract, and 1 part of hydrolyzed royal jelly protein.

[0057] Wherein, the preparation method of the liposome comprises the following steps:

[0058] (1) adding lecithin and phytosterol to an ethanol solution with a mass concentration of 80%, mixing them evenly, and removing the ethanol to obtain a lipid film;

[0059] (2) The camellia chrysantha extract and the hydrolyzed royal jelly protein are mixed evenly, added to the lipid film, heated and stirred evenly at 60° C., and then homogenized for 5 minutes under the conditions of a pressure of 800 bar and a rotation speed of 2000 rpm to obtain the product, and then the unencapsulated components are filtered out to obtain the liposome encapsulating the camellia chrysantha extract and the hydrolyzed royal jelly protein.

[0060] The preparation method of the whitening and repairing body care composition with mild exfoliation comprises the following steps:

[0061] After the liposomes, papain and bromelain were mixed, the mixture was stirred at a rotation speed of 500 r / min for 10 minutes to obtain the body care composition.

[0062] Example 4

[0063] The difference between Example 4 and Example 1 is that the amount of raw materials added to the core layer remains unchanged, and the weight ratio of Camellia chrysantha extract to hydrolyzed royal jelly protein is 1.5:1.

[0064] Example 5

[0065] The difference between Example 5 and Example 1 is that the amount of raw materials added to the core layer remains unchanged, and the weight ratio of Camellia chrysantha extract to hydrolyzed royal jelly protein is 3.5:1.

[0066] Example 6

[0067] The difference between Example 6 and Example 1 is that the amount of raw materials added to the core layer remains unchanged, and the weight ratio of Camellia chrysantha extract to hydrolyzed royal jelly protein is 2:1.

[0068] Example 7

[0069] The difference between Example 7 and Example 1 is that the amount of raw materials added to the core layer remains unchanged, and the weight ratio of Camellia chrysantha extract to hydrolyzed royal jelly protein is 3:1.

[0070] Example 8

[0071] The difference between Example 8 and Example 1 is that the total mass of the composition remains unchanged, and the mass ratio of liposomes, papain and bromelain is 80:1:3.

[0072] Example 9

[0073] The difference between Example 9 and Example 1 is that the total mass of the composition remains unchanged, and the mass ratio of liposome, papain and bromelain is 80:5:0.5.

[0074] Example 10

[0075] The difference between Example 10 and Example 1 is that the total mass of the composition remains unchanged, and the mass ratio of liposomes, papain and bromelain is 80:2:2.

[0076] Embodiment 11

[0077] The difference between Example 11 and Example 1 is that the total mass of the composition remains unchanged, and the mass ratio of liposomes, papain and bromelain is 80:3:1.

[0078] Comparative Example 1

[0079] The difference between Comparative Example 1 and Example 1 is that no camellia chrysantha extract is added to the liposomes in Comparative Example 1, and an equal amount of hydrolyzed royal jelly protein is used to make up for the missing amount.

[0080] Comparative Example 2

[0081] The difference between Comparative Example 2 and Example 1 is that: hydrolyzed royal jelly protein is not added to the liposomes of Comparative Example 2, and an equal amount of Camellia chrysantha extract is used to make up for the missing amount.

[0082] Comparative Example 3

[0083] The difference between Comparative Example 3 and Example 1 is that: in Comparative Example 3, liposomes are not added, and equal amounts of lecithin, phytosterols, camellia chrysantha extract and hydrolyzed royal jelly protein are directly added.

[0084] Comparative Example 4

[0085] The difference between Comparative Example 4 and Example 1 is that the total mass of the composition remains unchanged, liposomes are not added in Comparative Example 4, and papain and bromelain are used in a mass ratio of 3:2 to make up for the missing amount.

[0086] Comparative Example 5

[0087] The difference between Comparative Example 5 and Example 1 is that the total mass of the composition remains unchanged, papain is not added in Comparative Example 5, and liposomes and bromelain in a mass ratio of 80:2 are used to make up for the missing amount.

[0088] Comparative Example 6

[0089] The difference between Comparative Example 6 and Example 1 is that the total mass of the composition remains unchanged, bromelain is not added in Comparative Example 6, and liposomes and papain with a mass ratio of 80:3 are used to make up for the missing amount.

[0090] Application Examples 1-11 and Comparative Application Examples 1-6

[0091] The compositions of Examples 1-11 and Comparative Examples 1-6 were added to hand creams at a concentration of 10 wt % to obtain hand creams of Application Examples 1-11 and Comparative Application Examples 1-6. The formulas are shown in Table 1.

[0092] The preparation method of the hand cream of application examples 1-11 and comparative application examples 1-6 comprises the following steps:

[0093] The preparation method of hand cream comprises the following steps:

[0094] S1. Mix the moisturizer, thickener and 1 / 2 amount of deionized water, homogenize at 80° C. to form a uniform aqueous phase, mix the emulsifier at 85° C., and mix the aqueous phase and the emulsifier at 80° C. to obtain a mixture;

[0095] S2. Add the preservative to the mixture obtained in step S1 and stir evenly. After the temperature drops to 40° C., add the body care composition and the remaining deionized water and stir evenly. Finally, add a pH adjuster to adjust the pH to 6 to obtain the hand cream.

[0096] Table 1 Hand cream formula of application examples 1-11 and application comparative examples 1-6

[0097]

[0098]

[0099] Application Examples 12-13

[0100] The difference between Application Examples 12-13 and Application Example 1 is that the amount of the body care composition of Example 1 added in Application Example 12 is 5wt%, and the amount of the body care composition of Example 1 added in Application Example 13 is 20wt%, and the balance is made up by deionized water.

[0101] Application Comparative Example 7

[0102] The hand cream of Application Example 7 is prepared without adding the composition, and an equal amount of deionized water is used to replace the composition. The preparation method is the same as that of Application Example 1.

[0103] Performance Testing

[0104] 1. Cell experiments prove that the combination can exfoliate and increase collagen

[0105] Experimental method: The cell model used was a human 3D epidermal skin model (Guangdong Boxi Biotechnology Co., Ltd.), and the test conditions were: incubator temperature 37±1°C, saturated humidity, carbon dioxide 5±1%; the 3D epidermal model was cultured and processed according to the group, and then tested. The specific test was the determination of stratum corneum thickness and type I collagen content. The test method is as follows:

[0106] (1) The 3D epidermal skin model was cultured using EpiGrowth culture medium (Guangdong Boxi Biotechnology Co., Ltd.);

[0107] (2) Apply 25 μL of 0.1% sodium dodecyl sulfate (Sigma) on the surface of the 3D epidermal skin model and incubate for 30 min;

[0108] (3) The blank control group was uniformly smeared with 12.5 μL of the hand cream of Application Example 7 on the surface of the epidermal model, while the sample group was smeared with 12.5 μL of the hand cream of Application Examples 1-13 and Application Comparative Examples 1-6, respectively, and cultured for 24 hours;

[0109] (4) After the incubation period, the test substance remaining on the surface of the model was cleaned with PBS solution (Biosharp), fixed with 4% paraformaldehyde (Biosharp) for 24 h, and then removed by circular cutting;

[0110] (5) Determination of stratum corneum thickness: The tissue sections were stained with H&E (Biyuntian), photographed and observed under a microscope, and the images were collected and analyzed;

[0111] (6) Detection of type I collagen content: The tissues were lysed with RIPA cell lysis buffer containing protease inhibitors, and the lysed samples were centrifuged at 12000g for 5 minutes. The supernatant was collected and the type I collagen content of the supernatant of each group of tissues was detected using a human type I collagen (Col I) ELISA kit (Cat. No. ml057630, ELISA Biotechnology).

[0112] The following formula was used to calculate the change rate of stratum corneum thickness and collagen in each embodiment and comparative example:

[0113] Stratum corneum thickness reduction rate (%) = (blank control group - sample group) / blank control group * 100%;

[0114] Collagen increase rate (%) = (sample group - blank control group) / blank control group * 100%; the results are shown in Table 2.

[0115] Table 2 Data of stratum corneum reduction rate and collagen increase rate of each group of hand cream samples

[0116] Group Cuticle thickness reduction rate / % Collagen increase rate / % Application Example 1 36.7 244 Application Example 2 35.1 204 Application Example 3 22.5 201 Application Example 4 28.6 225 Application Example 5 28.1 221 Application Example 6 33.4 236 Application Example 7 33.0 239 Application Example 8 29.2 223 Application Example 9 38.6 219 Application Example 10 32.7 232 Application Example 11 36.1 238 Application Example 12 34.4 232 Application Example 13 36.3 240 Application Comparative Example 1 27.8 108 Application Comparative Example 2 26.2 113 Application Comparative Example 3 28.9 63 Application Comparative Example 4 42.3 -10.3 Application Comparative Example 5 10.8 87 Application Comparative Example 6 11.5 93

[0117] Among them, the higher the reduction rate of stratum corneum thickness, the stronger the exfoliating effect of the hand cream; the higher the collagen increase rate, the stronger the skin strengthening effect of the hand cream.

[0118] 2. Human efficacy test of hand cream in exfoliation, whitening, repairing and moisturizing

[0119] Experimental method: According to the "Technical Specification for Safety of Cosmetics" (2015), 120 Asian adult testers aged 18-60 with rough, dull and sensitive hand skin were selected and randomly divided into 20 groups, with 6 people in each group. The volunteers applied the samples on both hands once in the morning and evening every day (the samples were hand creams prepared by Application Examples 1-13 and Comparative Examples 1-7), and visited to collect data on the 0th day and the 28th day. After the visit, the volunteers washed their hands with hand sanitizer, sat in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 30 minutes, and then conducted the following tests: the brightness L value of the back of the hand was measured using the CK skin gloss test probe GL200; the melanin content MI value of the back of the hand was measured using the melanin skin detector Mexameter; the transepidermal water loss value TEWL of the back of the hand was measured using the skin moisture loss test probe TewaMeter; the skin moisture test probe Corneometer was used to measure the skin moisture content of the back of the hand.

[0120] The exfoliating ability is represented by the improvement of the skin brightness L value, the whitening ability is represented by the improvement of the melanin content MI value, the skin barrier repair ability is represented by the improvement of the essence water loss TEWL value, and the moisturizing effect is represented by the improvement of the skin moisture content.

[0121] The formulas for the improvement rate of L value, MI value, TEWL value and skin moisture content are as follows:

[0122] L value improvement rate = (T28-T0) / T0*100%;

[0123] MI value improvement rate = (T0-T28) / T0*100%;

[0124] TEWL value improvement rate = (T0-T28) / T0*100%;

[0125] Skin moisture content improvement rate = (T28-T0) / T0*100%;

[0126] The results are shown in Table 3.

[0127] Table 3 Test results of the human efficacy of each group of hand cream samples in exfoliation, whitening, repairing and moisturizing

[0128]

[0129]

[0130] It can be seen from Table 2-3 that, combined with the data of Application Examples 1 and 4-7, the weight ratio of Camellia chrysantha extract and hydrolyzed royal jelly protein in liposomes has a greater influence on the whitening, repairing and moisturizing effects of the hand cream. Therefore, when the weight ratio of Camellia chrysantha extract and hydrolyzed royal jelly protein is (2-3):1, the whitening, repairing and moisturizing effects of the hand cream can reach a better level.

[0131] Combining the data of Application Examples 1 and 8-11, it can be seen that the mass ratio of the liposome, papain, and bromelain affects exfoliation, whitening, repairing, and moisturizing. When the content of protease is high and the content of liposome is low, the exfoliation and whitening performance are good, but the repairing and moisturizing effects are significantly reduced. When the mass ratio of the liposome, papain, and bromelain is 80:(2-3):(1-2), the exfoliation and repairing of the hand cream are at a relatively good level.

[0132] Combining the data of Application Example 1 and Comparative Application Examples 1-2, it can be seen that adding Camellia chrysantha extract and hydrolyzed royal jelly protein to liposomes can synergistically improve the whitening, moisturizing and repairing properties of hand cream.

[0133] Combining the data of Application Example 1 and Comparative Example 3, it can be seen that encapsulating Camellia chrysantha extract and hydrolyzed royal jelly protein in liposomes can prevent both from being decomposed by proteases. While preventing them from reacting with proteases, it can also further promote the two to penetrate deep into the skin to exert their effects.

[0134] Combining the data of Application Example 1 and Application Comparative Examples 4-6, it can be seen that in Application Comparative Example 4, liposomes are not added, and the thickness of the stratum corneum is significantly reduced compared with Application Example 1, but the content of collagen, repair and moisturizing effects are significantly reduced. This is because the lack of liposomes to buffer and repair the protease causes greater damage to the stratum corneum. Application Comparative Examples 5-6 do not add papain and bromelain, respectively, and their exfoliation, whitening, repair and moisturizing effects are all lower than those of Application Example 1. This may be because the liposomes, papain and bromelain work synergistically to achieve the effects of mild exfoliation, whitening, repair and moisturizing.

[0135] 3. Human skin patch test.

[0136] 30 volunteers were recruited, including 27 males and 28 females, aged 20-50 years old. The closed patch test method was used. An equal amount (0.020mL-0.025mL) of the test sample (hand cream of application examples 1-13) was placed in a specific patch tester, which was applied to the volunteer's arm with a hypoallergenic tape, and gently pressed to evenly apply it on the skin for 24 hours; the blank control group was distilled water, and the blank application example was a lotion without whitening and tenderizing hand cream. After 24 hours, the patch tester was removed, and the skin reaction was observed after 0.5 hours, 24 hours, and 48 hours, and the results were recorded. The level of adverse reactions to the skin is shown in Table 4 below.

[0137] Table 4 Adverse skin reaction grade table

[0138]

[0139] After testing, the hand creams of Application Examples 1-13 all showed negative reactions after human patch tests, and they are safe and non-irritating to human skin.

[0140] In summary, the body care composition of the present invention can be applied to hand cream to achieve multiple functions of brightening skin tone, removing dead skin cells, and strengthening skin, while being safe, mild, and non-irritating.

[0141] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A mild exfoliating whitening and repairing body care composition, characterized in that: The invention is composed of the following components in parts by weight: 5-10 parts of liposomes, 0.01-1 parts of papain and 0.005-0.5 parts of bromelain; wherein the liposomes include a shell layer and a core layer, the shell layer includes lecithin and phytosterols, and the core layer includes camellia chrysantha extract and hydrolyzed royal jelly protein; the liposomes include the following raw materials in parts by weight: 2-15 parts of lecithin, 0.1-5 parts of phytosterols, 0.1-3 parts of camellia chrysantha extract and 0.01-1 parts of hydrolyzed royal jelly protein.

2. The mild exfoliating whitening and repairing body care composition according to claim 1, characterized in that: The weight ratio of the camellia chrysantha extract to the hydrolyzed royal jelly protein is (1.5-3.5):

1.

3. The mild exfoliating whitening and repairing body care composition according to claim 1, characterized in that: The mass ratio of the liposome, papain and bromelain is 80:(1-5):(0.5-3).

4. The mild exfoliating whitening and repairing body care composition according to claim 1, characterized in that: The preparation method of the liposome comprises the following steps: (1) adding lecithin and phytosterol to an ethanol solution, mixing them evenly, and removing the ethanol to obtain a lipid film; (2) The camellia chrysantha extract and the hydrolyzed royal jelly protein are mixed evenly, added to the lipid film, heated at 40-60° C. and stirred evenly, and then homogenized to obtain the product, and then the unencapsulated components are filtered out to obtain the liposome encapsulating the camellia chrysantha extract and the hydrolyzed royal jelly protein.

5. The mild exfoliating whitening and repairing body care composition according to claim 1, characterized in that: In step (2) of the liposome preparation method, the homogenization pressure is 500-800 bar, the homogenization speed is 1000-2000 rpm, and the homogenization time is 3-5 min.

6. Use of the mild exfoliating, whitening and repairing body care composition according to any one of claims 1 to 5 in the preparation of skin care products.

7. A hand cream, characterized in that: The invention comprises the following raw materials in weight percentage: 5%-20% of the mild exfoliating whitening and repairing body care composition according to any one of claims 1 to 5, 0.1%-0.3% of a thickener, 4%-6% of a moisturizer, 10-13% of an emulsifier, 1%-1.5% of a preservative and 0.1%-0.2% of a pH regulator, and the balance is deionized water.

8. The hand cream according to claim 7, characterized in that The raw material is selected from at least one of (a) to (e): (a) the thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol; (b) the moisturizing agent comprises at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butylene glycol, glycerol, budding pullulan polysaccharide, and ceramide; (c) the emulsifier comprises at least one of dimethicone, cetearyl alcohol, caprylic / capric triglyceride, glyceryl stearate citrate and PEG-100 stearate; (d) the preservative comprises at least one of 1,2-propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone; (e) The pH adjuster comprises at least one of arginine, tromethamine, and EDTA-disodium.

9. The method for preparing the hand cream according to claim 7, characterized in that: The following steps are involved: S1. After the humectant, thickener and part of deionized water are mixed evenly, they are homogenized at 75-85°C to form a uniform aqueous phase, the emulsifier is mixed evenly at 80-90°C, and the aqueous phase and the emulsifier are mixed evenly at 75-85°C to obtain a mixture; S2. Add the preservative to the mixture obtained in step S1 and stir evenly. After the temperature drops to 35-45° C., add the body care composition and the remaining deionized water and stir evenly. Finally, add a pH adjuster to adjust the pH to obtain the hand cream.

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