Compound nasopharyngitis nasal drops and preparation method thereof

Abstract

The invention relates to the technical field of medicine, and particularly discloses compound nasopharyngitis nasal drops and a preparation method thereof.The compound nasopharyngitis nasal drops are prepared from 10-15 parts of xanthium sibiricum, 8-12 parts of liquorice, 10-15 parts of platycodon grandiflorum, 12-18 parts of magnolia flowers, 8-12 parts of radix angelicae and 15-20 parts of centipeda minima; according to the traditional Chinese medicine composition, a natural plant formula is adopted, the nasopharyngitis symptom can be effectively improved through cooperation of all the components, the effective components of all the components can be effectively extracted through a secondary decoction preparation method, the extraction rate of the effective components in all the components is greatly increased, and then the medicine effect of the traditional Chinese medicine composition is improved; meanwhile, the nasal drops are prepared into water emulsion, so that a layer of protective film can be formed on the mucous membrane surface of the nasal cavity when the nasal drops are used, the retention time of the medicine in the nasal cavity is prolonged, and the absorption and treatment effects of the medicine are enhanced.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, and in particular to a compound nasopharyngitis nasal drops and a preparation method thereof. Background Art

[0002] Nasopharyngitis is an inflammation of the nasopharyngeal mucosa, submucosal and lymphoid tissues. The nasopharynx is in a special location, at the junction of the posterior end of the nasal cavity and the pharynx. It is a passage for breathing and a part of the body's defense system. Nasopharyngitis can be divided into acute nasopharyngitis and chronic nasopharyngitis. Acute nasopharyngitis is often part of an upper respiratory tract infection, mostly caused by viral infections such as rhinoviruses and coronaviruses, which may be followed by secondary bacterial infections such as hemolytic streptococci and staphylococci. Chronic nasopharyngitis can be caused by multiple factors, such as repeated attacks of acute nasopharyngitis, the influence of nasal and sinus diseases, environmental factors (such as long-term exposure to chemicals, dust, etc.) or bad living habits (such as long-term smoking and drinking).

[0003] For the treatment of nasopharyngitis, the existing treatment methods are mainly divided into two types: local therapeutic drugs and systemic therapeutic drugs. Among them, systemic therapeutic drugs, whose main ingredients are antibiotics such as penicillin or cephalosporin, have good therapeutic effects on acute nasopharyngitis caused by viruses, but repeated use will not only produce drug resistance but also cause harm to the body, so they are not suitable for recurrent chronic nasopharyngitis; local therapeutic drugs, mainly sprays, use nasal sprays to alleviate the symptoms of nasopharyngitis, and are mainly used for chronic nasopharyngitis.

[0004] Existing sprays for the treatment of nasopharyngitis are divided into chemical synthesis type and natural plant extraction type according to their main ingredients. Chemical synthesis type sprays have a quick effect, but their long-term use not only has obvious side effects, but also will produce drug resistance, affecting the treatment effect; and although natural plant extraction type sprays do not have the above problems, their treatment effect is not obvious and the duration of drug effect is short.

[0005] Therefore, it is necessary to design a compound nasopharyngitis nasal drops to solve the problem that the existing natural plant extract sprays have an insignificant therapeutic effect and a short duration of efficacy. Summary of the invention

[0006] In view of this, the present invention proposes a compound nasopharyngitis nasal drops, which aims to solve the problem that the natural plant extract spray has an insignificant therapeutic effect and a short duration of drug effect.

[0007] On the one hand, the present invention provides a compound nasopharyngitis nasal drops, comprising the following components in parts by weight:

[0008] 10-15 parts of Xanthium sibiricum, 8-12 parts of Licorice, 10-15 parts of Platycodon grandiflorum, 12-18 parts of Magnolia flos, 8-12 parts of Angelica dahurica and 15-20 parts of Herba Capillaris;

[0009] On the other hand, the present invention provides a method for preparing a compound nasopharyngitis nasal drops, comprising the following preparation steps:

[0010] Pre-treat Xanthium sibiricum, Licorice root, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Herba Caprifoliaceae for later use;

[0011] The pretreated Xanthium sibiricum, Licorice, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Herba Capillaris are soaked in water, and then decocted for the first time, and then filtered to obtain a first filtrate and a filter residue;

[0012] Add the filter residue into water and perform a second decocting, and filter after the decocting to obtain a second filtrate;

[0013] The first filtrate and the second filtrate are mixed, and an emulsifier is added and stirred to form an aqueous emulsion to obtain the compound nasopharyngitis nasal drops.

[0014] Furthermore, the pretreatment is specifically as follows: rinsing Xanthium sibiricum and Herba Glechomae for 3-5 minutes; cutting Licorice into small pieces of 0.5-1 cm; rinsing Platycodon grandiflorum and Angelica dahurica for 3-5 minutes and then cutting into thin slices of 0.2-0.3 cm; rubbing off the fluff on the surface of Magnolia officinalis flower and rinsing for 10-15 seconds and then drying naturally;

[0015] Furthermore, the first frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 10 minutes, and then lowering the temperature to 80° C. and frying for 30 minutes.

[0016] Furthermore, the second frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 5 minutes, and then lowering the temperature to 80° C. and frying for 25 minutes.

[0017] Furthermore, the stirring is performed at a speed of 50-60 revolutions per minute during the first frying and the second frying.

[0018] Furthermore, the volume of the emulsifier is 3%-5% of the total volume of the first filtrate and the second filtrate.

[0019] Furthermore, when the emulsifier is added for stirring, the stirring speed is 200-300 revolutions per minute.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows: by adopting a natural plant formula, the side effects of the drug are reduced to the greatest extent, and the problems of drug dependence and drug resistance are avoided; at the same time, the preparation method of double decoction can effectively extract the effective ingredients of each component, greatly improving the extraction rate of the effective ingredients of each component, thereby improving the drug efficacy of the present invention; at the same time, the present invention makes the nasal drops into an emulsion so that a protective film can be formed on the surface of the nasal mucosa when used, prolonging the residence time of the drug in the nasal cavity, thereby enhancing the absorption and therapeutic effect of the drug. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Moreover, the same reference symbols are used throughout the accompanying drawings to represent the same components. In the accompanying drawings:

[0022] Figure 1 The present invention provides a flow chart of a method for preparing the compound nasopharyngeal nasal drops. DETAILED DESCRIPTION

[0023] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art. It should be noted that, in the absence of conflict, the embodiments of the present invention and the features described in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0024] For the treatment of nasopharyngitis, the existing treatment methods are mainly divided into two types: local therapeutic drugs and systemic therapeutic drugs. Among them, systemic therapeutic drugs, whose main ingredients are mainly antibiotics such as penicillin or cephalosporin, have a good therapeutic effect on acute nasopharyngitis caused by viruses, but repeated use will not only produce drug resistance but also cause harm to the body, so they are not suitable for recurrent chronic nasopharyngitis; while local therapeutic drugs are mainly sprays, which are used to relieve the symptoms of nasopharyngitis through nasal sprays, and are mainly used for chronic nasopharyngitis; the existing sprays for the treatment of nasopharyngitis are divided into chemical synthesis and natural plant extraction according to their main ingredients. The chemical synthesis sprays have a faster effect, but in long-term use, not only are there obvious side effects, but also drug resistance will be produced, affecting the therapeutic effect; and although the natural plant extraction sprays do not have the above problems, their therapeutic effect is not obvious and the duration of drug effect is short. Therefore, it is necessary to design a compound nasopharyngitis nasal drops to solve the problems of the existing natural plant extraction sprays having an insignificant therapeutic effect and a short duration of drug effect.

[0025] On the one hand, in some embodiments of the present application, a compound nasopharyngitis nasal drops comprises the following components in parts by weight: 10-15 parts of Xanthium sibiricum, 8-12 parts of Licorice, 10-15 parts of Platycodon grandiflorum, 12-18 parts of Magnolia officinalis flower, 8-12 parts of Angelica dahurica and 15-20 parts of Herba Capillaris;

[0026] Preferably, 13-15 parts of Xanthium sibiricum, 10-12 parts of Licorice, 13-15 parts of Platycodon grandiflorum, 16-18 parts of Magnolia officinalis flower, 10-12 parts of Angelica dahurica and 18-20 parts of Herba Capillaris;

[0027] More preferably, 13 parts of Xanthium sibiricum, 10 parts of Licorice, 13 parts of Platycodon grandiflorum, 16 parts of Magnolia flos, 10 parts of Angelica dahurica and 18 parts of Herba Lysimachiae;

[0028] It is understandable that Xanthium sibiricum has the effects of dispersing wind and dampness, opening the orifices and relieving pain. The active ingredients in Xanthium sibiricum seeds can reduce the congestion and swelling of the nasal mucosa, have a good effect on relieving nasal congestion symptoms caused by nasopharyngitis, and can help restore the normal ventilation function of the nasal cavity.

[0029] It is understandable that licorice has many functions such as tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, etc. At the same time, the anti-inflammatory and anti-allergic properties of licorice can reduce the inflammatory response of the nasal mucosa, relieve the itching, pain and other discomfort symptoms caused by inflammatory stimulation, and help prevent the occurrence of allergic reactions.

[0030] It is understandable that Platycodon grandiflorum can clear the lungs, relieve sore throat and eliminate phlegm. It can improve discomfort in the throat, reduce symptoms such as sore throat, dryness, and foreign body sensation caused by pharyngitis, and at the same time promote the discharge of phlegm, which is beneficial to reduce the inflammatory burden of the respiratory tract.

[0031] It is understandable that magnolia flowers can dilate nasal blood vessels, improve nasal blood circulation, reduce congestion and swelling of the nasal mucosa, and thus effectively relieve symptoms such as nasal congestion and runny nose.

[0032] It is understandable that Angelica dahurica has the effects of dispelling wind and relieving pain, reducing swelling and discharging pus, and opening the orifices and dispersing cold. It can reduce inflammation and swelling of the nasal mucosa, relieve symptoms such as nasal pain, and promote the discharge of inflammatory products in the nasal cavity, helping to repair the nasal mucosa.

[0033] It is understandable that goose grass has the effect of clearing nasal air and benefiting the nine orifices. Goose grass can stimulate the nasal mucosa, increase nasal secretions, help clean the nasal cavity, and at the same time relieve nasal congestion and enhance the nasal ventilation capacity.

[0034] On the other hand, in some embodiments of the present application, a method for preparing a compound nasopharyngitis nasal drops comprises:

[0035] Pre-treat Xanthium sibiricum, Licorice root, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Herba Caprifoliaceae for later use;

[0036] The pretreated Xanthium sibiricum, Licorice, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Herba Capillaris are soaked in water, and then decocted for the first time, and then filtered to obtain a first filtrate and a filter residue;

[0037] Add the filter residue into water and perform a second decocting, and filter after the decocting to obtain a second filtrate;

[0038] The first filtrate and the second filtrate are mixed, and an emulsifier is added and stirred until the mixture is in an emulsion state to obtain the compound nasopharyngitis nasal drops.

[0039] Specifically, the present invention improves the therapeutic effect through the synergy of various components. After the first decoction, the proportion of various components will not completely meet the optimal synergistic state due to the difference in extraction efficiency. The second decoction can further adjust the proportion of various components to make the synergistic effect between the active ingredients in the compound nasal drops more stable and optimized; for example, after the first decoction, the proportion of the active ingredients of Platycodon grandiflorum and Licorice is not conducive to fully exerting the synergistic effect of expectoration and anti-inflammatory. The second decoction can strengthen this synergistic effect, thereby enhancing the overall efficacy of the nasal drops.

[0040] Specifically, when the pretreated Xanthium sibiricum, Licorice, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Schisandra chinensis are soaked in water, the soaking time is 35 minutes; the first amount of water added is 7 times the total mass of the medicinal materials, and the second amount of water added is one third of the first amount of water added.

[0041] It is understandable that the active ingredients in Chinese herbal medicines have different dissolution characteristics. During the first decoction, those ingredients with high solubility and easy dissolution, such as volatile oils in magnolia flowers and glycyrrhizic acid in licorice, will be extracted; and during the second decoction, as the solvent contacts the drug residue again, some ingredients that were not fully dissolved in the first decoction, such as some fat-soluble ingredients in Xanthium sibiricum, will be more easily dissolved in the second decoction after the drug residue structure is destroyed after the first decoction; at the same time, through the second decoction, the active ingredients in the medicinal materials can be extracted to the greatest extent. This makes the use of medicinal materials more complete, and compared with a single decoction, it reduces the waste of active ingredients, thereby ensuring the efficacy while also improving the utilization efficiency of raw materials.

[0042] In some embodiments of the present application, the pretreatment is specifically as follows: rinse Xanthium sibiricum and Schefflera indica for 3-5 minutes; cut licorice into small segments of 0.5-1 cm; rinse Platycodon grandiflorum and Angelica dahurica for 3-5 minutes and cut into thin slices of 0.2-0.3 cm; rub off the fluff on the surface of magnolia flower, rinse for 10-15 seconds and dry naturally; the rinsing time of Xanthium sibiricum, Schefflera indica, Platycodon grandiflorum and Angelica dahurica is preferably 4 minutes, and the rinsing time of magnolia flower is preferably 13 seconds.

[0043] In some embodiments of the present application, the first frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 10 minutes, and then lowering the temperature to 80° C. and frying for 30 minutes.

[0044] It is understandable that during the 10-minute decocting stage at 100°C, the higher temperature is conducive to the extraction of some low-boiling-point, volatile active ingredients. For example, magnolia flowers contain volatile oils, which can be quickly dissolved at high temperatures. If a lower temperature is used for decocting, the extraction efficiency of the volatile oil components will be relatively low. The initial high temperature can make these volatile components that play an important role in the treatment of nasopharyngitis, such as linalool, citral, etc., fully released from the medicinal materials, ensuring that the nasal drops can improve nasal ventilation and reduce inflammation. During the 30-minute decocting stage at 80°C, this temperature is more suitable for extracting those components that are not resistant to high temperatures, such as glycyrrhizic acid in licorice and saponins in platycodon. They will decompose or change their structure at too high a temperature, affecting their efficacy. Prolonging the decocting time at a lower temperature can fully extract these components from the medicinal materials while ensuring their stability, so that the nasal drops contain a variety of different types of active ingredients, which can play a therapeutic role in nasopharyngitis from multiple angles.

[0045] It is understandable that in addition to the effective ingredients, Chinese herbal medicines also contain some components that are prone to change at high temperatures. If they are decocted at a high temperature of 100°C for a long time, some components will decompose, polymerize or produce harmful substances.

[0046] It is understandable that this method of decocting at high temperatures first and then low temperatures can better control the extraction ratios of different ingredients, so that various effective ingredients can be extracted in a more ideal ratio, which is conducive to the synergistic effect between different ingredients; for example, the coumarin components in Angelica dahurica and the flavonoid components in Herba Epimedii can be dissolved in a suitable ratio under this temperature control, thereby enhancing the comprehensive medicinal effects of the nasal drops such as anti-inflammatory and orifice-opening, and improving the quality of the product.

[0047] In some embodiments of the present application, the second frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 5 minutes, and then lowering the temperature to 80° C. and frying for 25 minutes.

[0048] In some embodiments of the present application, the stirring speed during the first frying and the second frying is 50-60 revolutions per minute; the stirring speed is preferably 55 revolutions per minute.

[0049] In some embodiments of the present application, the volume of the emulsifier is 3%-5% of the total volume of the first filtrate and the second filtrate; the volume of the emulsifier is preferably 4% of the total volume of the first filtrate and the second filtrate.

[0050] Specifically, the emulsifier is preferably Tween-80.

[0051] Specifically, water-emulsion dosage forms can encapsulate some unstable drug ingredients inside the emulsion to protect them from external factors (such as light, oxidation, etc.). In particular, plant extracts that are sensitive to light or oxygen can be better protected in the water-emulsion structure, thereby extending the shelf life of the product and ensuring that the effectiveness of the drug will not drop significantly during the storage period.

[0052] It is understandable that aqueous emulsion nasal drops have better physical stability and are less prone to stratification, precipitation and the like under normal storage and transportation conditions; this makes it easy to store and carry, and patients can conveniently keep it with them and use it whenever needed without worrying about the quality of the nasal drops being affected.

[0053] It is understandable that when the nasal drops are prepared into an aqueous emulsion and are dropped into the nasal cavity, the oil phase components in the emulsion will form a thin film on the surface of the nasal mucosa. This thin film can slow down the release rate of the drug, thereby prolonging the residence time of the drug in the nasal cavity. The active ingredients of the drug can be in contact with the nasal mucosa for a longer period of time, thereby having more time to be absorbed into the mucosal tissue, thereby enhancing the therapeutic effect of the drug.

[0054] It is understandable that emulsifiers can help drugs better penetrate mucosal epithelial cells, making them more easily absorbed into the blood circulation or local tissues, thereby more effectively playing a therapeutic role in nasopharyngitis.

[0055] It is understandable that the nasal mucosa is relatively sensitive, and traditional nasal drops can cause nasal discomfort due to excessively high drug concentrations or irritating ingredients; aqueous emulsions are relatively milder, the water phase can dilute the drug concentration, and the oil phase can isolate the direct contact between the drug and the mucosa to a certain extent, reducing drug irritation to the mucosa.

[0056] In some embodiments of the present application, when the emulsifier is added for stirring, the stirring speed is 200-300 revolutions per minute, and the stirring speed is preferably 250 revolutions per minute.

[0057] Example 1

[0058] S1. Rinse Xanthium sibiricum and Herba Glechomae var. truncatum for 3-5 minutes; cut licorice into small pieces of 0.5-1 cm; rinse Platycodon grandiflorum and Angelica dahuricae dahuricae for 3-5 minutes and cut into thin slices of 0.2-0.3 cm; rub off the fluff on the surface of Magnolia officinalis flower, rinse for 10-15 seconds and dry naturally;

[0059] S2, taking 10 parts of pretreated Xanthium sibiricum, 8 parts of Licorice, 10 parts of Platycodon grandiflorum, 12 parts of Magnolia flos, 8 parts of Angelica dahurica and 15 parts of Herba Capillaris, and soaking them in 441 parts of water for 35 minutes, first raising the temperature to 100°C and decocting for 10 minutes, then lowering the temperature to 80°C and decocting for 30 minutes, stirring continuously at a speed of 50 revolutions per minute during the decocting period, and filtering after completion to obtain a first filtrate and a filter residue;

[0060] S3, after adding the filter residue into 147 parts of water, raising the temperature to 100°C and boiling for 5 minutes, then lowering the temperature to 80°C and boiling for 25 minutes, stirring continuously at a speed of 50 revolutions per minute during boiling, filtering after completion to obtain a second filtrate;.

[0061] S4. The first filtrate and the second filtrate are mixed, 3% of the total volume of Tween-80 of the first filtrate and the second filtrate are added, and then stirred at a speed of 200 revolutions per minute until the mixture becomes an aqueous emulsion, to obtain the compound nasopharyngeal nasal drops.

[0062] Example 2

[0063] S1. Rinse Xanthium sibiricum and Herba Glechomae var. erythrorhizome for 3 minutes; cut licorice into small pieces of 0.5-1 cm; rinse Platycodon grandiflorum and Angelica dahuricae dahuricae var. erythrorhizome for 3 minutes and cut into thin slices of 0.2-0.3 cm; rub off the fluff on the surface of Magnolia officinalis flower, rinse for 13 seconds and dry naturally;

[0064] S2, taking 13 parts of Xanthium sibiricum, 10 parts of Licorice, 13 parts of Platycodon grandiflorum, 16 parts of Magnolia flos, 10 parts of Angelica dahurica and 18 parts of Herba Capillaris after pretreatment, and soaking them in 560 parts of water for 35 minutes, first raising the temperature to 100°C and decocting for 10 minutes, then lowering the temperature to 80°C and decocting for 30 minutes, stirring continuously at a speed of 55 revolutions per minute during the decocting period, and filtering after completion to obtain a first filtrate and a filter residue;

[0065] S3, after adding the filter residue into 186 parts of water, raising the temperature to 100°C and boiling for 5 minutes, then lowering the temperature to 80°C and boiling for 25 minutes, stirring continuously at a speed of 55 revolutions per minute during boiling, filtering after completion to obtain a second filtrate;.

[0066] S4. The first filtrate and the second filtrate are mixed, 4% of the total volume of Tween-80 of the first filtrate and the second filtrate are added, and then stirred at a speed of 250 revolutions per minute until the mixture becomes an aqueous emulsion, to obtain the compound nasopharyngeal nasal drops.

[0067] Example 3

[0068] S1. Rinse Xanthium sibiricum and Herba Glechomae Semen for 5 minutes; cut licorice into small pieces of 0.5-1 cm; rinse Platycodon grandiflorum and Angelica dahurica for 5 minutes and cut into thin slices of 0.2-0.3 cm; rub off the fluff on the surface of Magnolia officinalis, rinse for 15 seconds and dry naturally;

[0069] S2, taking 15 parts of pretreated Xanthium sibiricum, 12 parts of Licorice, 15 parts of Platycodon grandiflorum, 18 parts of Magnolia flos, 12 parts of Angelica dahurica and 20 parts of Herba Capillaris, and soaking them in 644 parts of water for 35 minutes, first raising the temperature to 100°C and decocting for 10 minutes, then lowering the temperature to 80°C and decocting for 30 minutes, stirring continuously at a speed of 60 revolutions per minute during the decocting period, and filtering after completion to obtain a first filtrate and a filter residue;

[0070] S3, after adding the filter residue into 214 parts of water, raising the temperature to 100°C and boiling for 5 minutes, then lowering the temperature to 80°C and boiling for 25 minutes, stirring continuously at a speed of 60 revolutions per minute during boiling, filtering after completion to obtain a second filtrate;.

[0071] S4. The first filtrate and the second filtrate are mixed, 5% of the total volume of Tween-80 of the first filtrate and the second filtrate are added, and then stirred at a speed of 350 revolutions per minute until the mixture becomes an aqueous emulsion, to obtain the compound nasopharyngeal nasal drops.

[0072] It should be noted that:

[0073] In the description provided herein, a large number of specific details are described. However, it is understood that the embodiments of the present application can be practiced without these specific details. In some instances, well-known structures and technologies are not shown in detail so as not to obscure the understanding of this description.

[0074] Similarly, it should be understood that in order to streamline the present application and aid in understanding one or more of the various inventive aspects, in the above description of the exemplary embodiments of the present application, the various features of the present application are sometimes grouped together into a single embodiment, figure, or description thereof. However, the disclosed system should not be interpreted as reflecting the following schematic diagram: the claimed application requires more features than those explicitly recited in each claim.

[0075] Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment.The claims following the Detailed Description are thus hereby expressly incorporated into this Detailed Description, with each claim standing on its own as a separate embodiment of this application.

[0076] Furthermore, those skilled in the art will appreciate that although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features from different embodiments is meant to be within the scope of the present application and to form different embodiments.

[0077] For example, in the following claims, any of the claimed embodiments can be used in any combination.

[0078] The above is only a preferred specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed in the present application should be included in the protection scope of the present application. Therefore, the protection scope of the present application shall be based on the protection scope of the claims.

Claims

1. A compound nasopharyngitis nasal drops, characterized in that: The invention comprises the following components in parts by weight: 10-15 parts of Xanthium sibiricum, 8-12 parts of Licorice, 10-15 parts of Platycodon grandiflorum, 12-18 parts of Magnolia officinalis flower, 8-12 parts of Angelica dahurica and 15-20 parts of Herba Capillaris.

2. A method for preparing the compound nasopharyngitis nasal drops according to claim 1, characterized in that: The method comprises the following preparation steps: Pre-treat Xanthium sibiricum, Licorice root, Platycodon grandiflorum, Magnolia flower, Angelica dahurica and Herba Caprifoliaceae for later use; The pretreated Xanthium sibiricum, licorice, platycodon grandiflorum, magnolia flower, angelica dahurica and schefflera are soaked in water, and then decocted for the first time, and filtered after the decoction is completed to obtain a first filtrate and a filter residue; Add the filter residue into water and perform a second decocting, and filter after the decocting to obtain a second filtrate; The first filtrate and the second filtrate are mixed, and an emulsifier is added and stirred until the mixture is in an emulsion state to obtain the compound nasopharyngitis nasal drops.

3. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: The pretreatment is specifically as follows: rinsing Xanthium sibiricum and Herba Glechomae for 3-5 minutes; cutting Licorice into small segments of 0.5-1 cm; rinsing Platycodon grandiflorum and Angelica dahurica for 3-5 minutes and then cutting into thin slices of 0.2-0.3 cm; rubbing off the fluff on the surface of Magnolia officinalis flower, rinsing for 10-15 seconds and then drying naturally.

4. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: The first frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 10 minutes, and then lowering the temperature to 80° C. and frying for 30 minutes.

5. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: The second frying is specifically as follows: firstly raising the temperature to 100° C. and frying for 5 minutes, and then lowering the temperature to 80° C. and frying for 25 minutes.

6. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: During the first frying and the second frying, stirring is continued at a speed of 50-60 revolutions per minute.

7. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: The volume of the emulsifier is 3%-5% of the total volume of the first filtrate and the second filtrate.

8. The method for preparing the compound nasopharyngitis nasal drops according to claim 2, characterized in that: When the emulsifier is added for stirring, the stirring speed is 200-300 revolutions per minute.

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