Traditional Chinese medicine spray containing agilawood, preparation method of traditional Chinese medicine spray and application of traditional Chinese medicine spray in nasal cavity

Abstract

The invention belongs to the technical field of nasal spray, and provides traditional Chinese medicine spray containing agilawood, a preparation method of the traditional Chinese medicine spray and application of the traditional Chinese medicine spray in nasal cavities. The traditional Chinese medicine spray contains a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared from the following raw materials in parts by mass: 5-10 parts of agilawood, 10-20 parts of folium artemisiae argyi, 20-30 parts of flos magnoliae, 5-10 parts of ampelopsis grossedentata tea, 8-12 parts of fructus xanthii, 8-12 parts of veratrum nigrum, 5-10 parts of galangal, 5-10 parts of rhizoma acori graminei and 2-4 parts of borneol. The traditional Chinese medicine spray disclosed by the invention has an excellent antibacterial rate and a remarkable effect on allergic rhinitis, and the effective rate reaches 96.7% or above. The traditional Chinese medicine spray is locally applied and absorbed in the nasal cavity, is suitable for people of all ages, is safe and free of adverse reaction, and has the advantages of being convenient and simple to use, high in absorption speed, sufficient in absorption, free of side effects on the body, high in patient compliance and the like.

Description

Technical Field

[0001] The invention relates to the technical field of nasal sprays, and in particular to a traditional Chinese medicine spray containing agarwood, a preparation method thereof, and application in the nasal cavity. Background Art

[0002] There are various microorganisms inside the nasal cavity. When the skin and mucous membranes of the nose are damaged, infection is prone to occur. The nasal cavity is closely related to the eyes, ears, and brain. Nasal infections can also cause complications of the eyes, ears, and brain. There are many nasal diseases, the most common of which is rhinitis. Rhinitis mainly includes acute rhinitis, chronic rhinitis, sinusitis, and frontal sinusitis. The main symptoms are dizziness, headache, runny nose, and nasal congestion. There are many drugs for the treatment of rhinitis, mainly oral and spray forms. The main disadvantage of oral drugs is that they must be decomposed by the digestive tract, sent to the liver for processing, and then sent to the nasal mucosa through the systemic circulation. The amount of medicine that can reach the nose is very small, and the effect produced is even less. Therefore, it has the disadvantages of slow onset and low efficacy. Oral drugs not only have large dosages, but also have problems such as intestinal toxicity and side effects and low bioavailability.

[0003] Nasal sprays are administered through the nasal cavity. The nasal mucosal microvilli have a large surface area and high permeability. Their high permeability and high vascularization ensure rapid absorption of drugs and improved therapeutic effects. They are protected from damage by enzymes in the gastrointestinal tract and the first-pass effect of the liver on drugs, making it easier for drugs to be absorbed. However, sprays in the prior art are difficult to have both anti-inflammatory and antibacterial properties and the ability to treat rhinitis.

[0004] Agarwood has the effects of promoting qi and relieving pain, warming the middle and stopping vomiting, and promoting qi and relieving asthma, and can be used to treat symptoms such as cold stagnation and qi stagnation, chest and abdominal distension and pain, asthma due to kidney deficiency, poor appetite and less food intake. Agarwood has certain effects of relieving exterior symptoms and clearing away heat, promoting qi and relieving pain, and can relieve symptoms such as nasal congestion and headache caused by rhinitis. Therefore, it is of great value to provide a Chinese medicine spray containing agarwood with excellent anti-inflammatory and antibacterial effects and rhinitis prevention and treatment effects. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine spray containing agarwood and a preparation method thereof and application in the nasal cavity in view of the deficiencies in the prior art.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a traditional Chinese medicine spray containing agarwood, wherein the traditional Chinese medicine spray contains a traditional Chinese medicine extract; the traditional Chinese medicine extract contains the following raw materials in parts by weight: 5-10 parts of agarwood, 10-20 parts of wormwood leaves, 20-30 parts of magnolia, 5-10 parts of rockberry tea, 8-12 parts of Xanthium sibiricum, 5-10 parts of Veratrum, 8-12 parts of galangal, 5-10 parts of calamus, and 2-4 parts of borneol.

[0008] Preferably, the Chinese medicine extract comprises the following raw materials in parts by mass: 6-9 parts of agarwood, 12-18 parts of mugwort, 22-28 parts of magnolia, 6-9 parts of rockberry tea, 9-11 parts of Xanthium sibiricum, 9-11 parts of Veratrum, 6-9 parts of galangal, 6-9 parts of calamus, and 3 parts of borneol.

[0009] Preferably, the Chinese medicine spray further comprises auxiliary materials, which are water and glycerin.

[0010] Preferably, the volume ratio of water to glycerol is 10:2-3.

[0011] The present invention also provides a method for preparing the Chinese medicine spray containing agarwood, comprising the following steps:

[0012] 1) mixing agarwood, wormwood leaf, magnolia, cyperus rotundus, Xanthium sibiricum, Veratrum, ginger, Acorus calamus and borneol, and then grinding them into mixed powder, adding water to the mixed powder for decoction, combining the extracts, and concentrating them to obtain a Chinese medicine extract;

[0013] 2) The Chinese medicine extract and the auxiliary materials are mixed to obtain a Chinese medicine spray containing agarwood.

[0014] Preferably, the decoction extraction temperature is 90-100°C, and the decoction extraction is performed 2-3 times.

[0015] Preferably, the time for each decoction and extraction is 40 to 60 minutes, and in each decoction and extraction, the mass ratio of the mixed powder to water is 1:6 to 10.

[0016] Preferably, the mass ratio of the Chinese herbal extract to the auxiliary material is 1 to 2:10.

[0017] The present invention also provides the use of the traditional Chinese medicine spray containing agarwood in the nasal cavity.

[0018] The beneficial effects of the present invention include:

[0019] The present invention significantly improves the antibacterial and anti-inflammatory effects and rhinitis treatment effects of the traditional Chinese medicine spray by reasonably selecting various raw materials and controlling the dosage of various raw materials; the traditional Chinese medicine spray has an excellent antibacterial rate and has a significant effect on allergic rhinitis, with an effective rate of more than 96.7%. The traditional Chinese medicine spray of the present invention is locally applied to the nasal cavity and locally absorbed, is suitable for people of all ages, is safe and has no adverse reactions, is easy to use, has a fast absorption speed, is fully absorbed, has no side effects on the body, and has high patient compliance. DETAILED DESCRIPTION

[0020] The present invention provides a traditional Chinese medicine spray containing agarwood, wherein the traditional Chinese medicine spray contains a traditional Chinese medicine extract; the traditional Chinese medicine extract contains the following raw materials in parts by weight: 5-10 parts of agarwood, 10-20 parts of wormwood leaves, 20-30 parts of magnolia, 5-10 parts of rockberry tea, 8-12 parts of Xanthium sibiricum, 5-10 parts of Veratrum, 8-12 parts of galangal, 5-10 parts of calamus, and 2-4 parts of borneol.

[0021] The Chinese medicine extract of the present invention comprises 5 to 10 parts of agarwood, preferably 6 to 9 parts, and more preferably 7 to 8 parts; the Chinese medicine extract of the present invention comprises 10 to 20 parts of mugwort, preferably 12 to 18 parts, more preferably 14 to 16 parts, and more preferably 15 parts; the Chinese medicine extract of the present invention comprises 20 to 30 parts of magnolia, preferably 22 to 28 parts, more preferably 24 to 26 parts, and more preferably 25 parts; the Chinese medicine extract of the present invention comprises 5 to 10 parts of rockberry tea, preferably 6 to 9 parts, and more preferably 7 to 8 parts; the Chinese medicine extract of the present invention comprises 10 to 20 parts of mugwort, preferably 12 to 18 parts, more preferably 14 to 16 parts, and more preferably 15 parts; The extract contains 8 to 12 parts of Xanthium sibiricum, preferably 9 to 11 parts, and more preferably 10 parts; the Chinese medicine extract of the present invention contains 5 to 10 parts of Veratrum, preferably 6 to 9 parts, and more preferably 7 to 8 parts; the Chinese medicine extract of the present invention contains 8 to 12 parts of Ginger galangal, preferably 9 to 11 parts, and more preferably 10 parts; the Chinese medicine extract of the present invention contains 5 to 10 parts of Acorus calamus, preferably 6 to 9 parts, and more preferably 7 to 8 parts; the Chinese medicine extract of the present invention contains 2 to 4 parts of borneol, preferably 2.5 to 3.5 parts, and more preferably 3 parts.

[0022] In the present invention, mugwort has multiple functions such as hemostasis, analgesia, antibacterial, antiviral, antiallergic, antitussive, and antiasthmatic; magnolia has the functions of dispersing wind and cold, clearing the nasal passages, anti-inflammatory, and anti-allergic, and can be used to treat various nasal diseases, such as acute rhinitis, chronic rhinitis, allergic rhinitis, etc.; the flavonoids content of rockberry tea is high, and it has the functions of bactericidal and anti-inflammatory, clearing away heat and detoxifying, analgesic and detumescent, moistening the throat and relieving cough, improving human immunity, and anti-allergic; Xanthium sibiricum has the functions of dispersing wind and dampness, clearing the orifices and relieving pain; Veratrum enters the liver meridian and has antifungal effect; southern ginger is pungent and hot, can promote qi circulation, relieve pain and eliminate phlegm, and has antibacterial effect; Acorus calamus has the functions of eliminating phlegm and opening the orifices, calming the mind, invigorating the spleen and stimulating the appetite; borneol has a certain inhibitory effect on staphylococcus, some pathogenic skin fungi, etc., and has good antibacterial and anti-inflammatory effects.

[0023] In the present invention, the Chinese medicine spray further comprises auxiliary materials, and the auxiliary materials are preferably water and glycerin.

[0024] In the present invention, the volume ratio of water to glycerol is preferably 10:2-3, and more preferably 10:2.5.

[0025] The present invention also provides a method for preparing the Chinese medicine spray containing agarwood, comprising the following steps:

[0026] 1) mixing agarwood, wormwood leaf, magnolia, cyperus rotundus, Xanthium sibiricum, Veratrum, ginger, Acorus calamus and borneol, and then grinding them into mixed powder, adding water to the mixed powder for decoction, combining the extracts, and concentrating them to obtain a Chinese medicine extract;

[0027] 2) The Chinese medicine extract and the auxiliary materials are mixed to obtain a Chinese medicine spray containing agarwood.

[0028] In the present invention, the temperature of the decoction extraction is preferably 90 to 100° C., more preferably 93 to 97° C., and even more preferably 95 to 96° C., and the number of decoction extractions is preferably 2 to 3 times.

[0029] In the present invention, the time for each decoction extraction is preferably 40 to 60 minutes, more preferably 45 to 55 minutes, and more preferably 50 minutes. In each decoction extraction, the mass ratio of the mixed powder to water is preferably 1:6 to 10, more preferably 1:7 to 9, and more preferably 1:8.

[0030] In the present invention, the mass ratio of the traditional Chinese medicine extract to the auxiliary material is preferably 1-2:10, more preferably 1.2-1.8:10, and more preferably 1.5:10.

[0031] The present invention also provides the use of the traditional Chinese medicine spray containing agarwood in the nasal cavity.

[0032] The traditional Chinese medicine spray containing agarwood of the present invention is used for cleaning the nasal cavity, preventing and treating rhinitis, inhibiting bacteria and resisting inflammation.

[0033] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0034] Example 1

[0035] In parts by mass, 5 parts of agarwood, 12 parts of mugwort, 22 parts of magnolia, 6 parts of rockberry tea, 11 parts of Xanthium sibiricum, 9 parts of Veratrum, 8 parts of galangal, 5 parts of Acorus calamus, and 2 parts of borneol were mixed evenly and crushed to obtain a mixed powder, water was added to the mixed powder (the mass ratio of water to the mixed powder was 10:1) for the first decoction extraction, and then water was added (the mass ratio of water to the mixed powder was 9:1) for the second decoction extraction. The temperature of the two decoction extractions was 90°C, and the time was 60 min. The filtrates were filtered, combined, and concentrated to obtain a traditional Chinese medicine extract (the water content of the traditional Chinese medicine extract was 20%).

[0036] The Chinese medicine extract and the auxiliary material are uniformly mixed in a mass ratio of 1:10, wherein the auxiliary material consists of water and glycerin in a volume ratio of 10:2, to obtain a Chinese medicine spray.

[0037] Example 2

[0038] In parts by mass, 10 parts of agarwood, 18 parts of mugwort, 28 parts of magnolia, 10 parts of rockberry tea, 8 parts of Xanthium sibiricum, 5 parts of Veratrum, 12 parts of galangal, 9 parts of calamus, and 4 parts of borneol were mixed evenly and crushed to obtain a mixed powder, water was added to the mixed powder (the mass ratio of water to the mixed powder was 7:1) for the first decoction extraction, and then water was added (the mass ratio of water to the mixed powder was 6:1) for the second decoction extraction, and water was added again (the mass ratio of water to the mixed powder was 6:1) for the third decoction extraction. The temperature of the three decoction extractions was 100°C, and the time was 40 min. The filtrates were filtered, combined, and concentrated to obtain a traditional Chinese medicine extract (the water content of the traditional Chinese medicine extract was 18%).

[0039] The Chinese medicine extract and the auxiliary material are uniformly mixed in a mass ratio of 2:10, wherein the auxiliary material consists of water and glycerin in a volume ratio of 10:3, to obtain a Chinese medicine spray.

[0040] Example 3

[0041] In terms of mass, 8 parts of agarwood, 15 parts of mugwort, 25 parts of magnolia, 8 parts of rockberry tea, 10 parts of Xanthium sibiricum, 8 parts of Veratrum, 10 parts of galangal, 8 parts of Acorus calamus, and 3 parts of borneol were mixed evenly and then crushed to obtain a mixed powder. Water (the mass ratio of water to the mixed powder is 8:1) was added to the mixed powder for the first decoction extraction, and then water (the mass ratio of water to the mixed powder is 7:1) was added for the second decoction extraction. The temperature of the two decoction extractions was 95°C, and the time was 50 min. The filtrates were filtered, combined, and concentrated to obtain a traditional Chinese medicine extract (the water content of the traditional Chinese medicine extract is 20%).

[0042] The Chinese medicine extract and the auxiliary material are uniformly mixed in a mass ratio of 1.5:10, wherein the auxiliary material consists of water and glycerin in a volume ratio of 10:2, to obtain a Chinese medicine spray.

[0043] Comparative Example 1

[0044] The agarwood and magnolia of Example 3 were omitted, 5 parts of wormwood and 20 parts of calamus were used, and one-time decoction extraction was adopted. The other process conditions were the same as those of Example 3.

[0045] Comparative Example 2

[0046] The wormwood leaf, Veratrum and borneol in Example 3 were omitted, 10 parts of magnolia and 20 parts of Xanthium sibiricum were used, the decoction extraction temperature was 70°C, and the other process conditions were the same as those in Example 3.

[0047] The performance tests were performed on the Chinese medicine sprays of Examples 1 to 3 and Comparative Examples 1 to 2.

[0048] Antibacterial performance test: Escherichia coli, Staphylococcus aureus and Streptococcus pneumoniae were cultured to the logarithmic phase, and 0.5 mL of the suspension containing 0.5 mcf of bacterial count turbidity was inoculated to the corresponding sterilized agar plate, and evenly coated, and then the sprays of Examples 1 to 3 and Comparative Examples 1 to 2 (0.5 mL each) were taken and sprayed into each agar plate, and three plates were repeated for each bacteria, and placed in a constant temperature incubator at 37 ° C. for 24 hours, and the diameter of the antibacterial zone was measured, and the average value was taken after 3 times. The results are shown in Table 1.

[0049] Table 1 Antibacterial performance test results of the sprays of the embodiments and comparative examples

[0050]

[0051]

[0052] The sprays of Examples 1 to 3 and Comparative Examples 1 to 2 were tested for allergic rhinitis.

[0053] 150 patients with allergic rhinitis, aged 30 to 50 years old, 80 males and 70 females, were randomly divided into 5 groups, 30 cases in each group. There was no statistical difference in gender, age and course of disease among the 5 groups. The 5 groups were respectively treated with the sprays of Examples 1 to 3 and Comparative Examples 1 to 2, sprayed 3 times a day, 1 mL each time. After 1 month of medication, the efficacy score (Table 2) and the treatment effect evaluation (Table 3) were performed.

[0054] Table 2 Efficacy scores of the sprays of the embodiments and comparative examples

[0055]

[0056] The calculation formula for the therapeutic effect of allergic rhinitis is: [(total score before treatment - total score after treatment) / total score before treatment] × 100%, where marked effect ≥ 60%, effective < 60%, and ≥ 25%, ineffective < 25%. The therapeutic effect is shown in Table 3.

[0057] Table 3 The therapeutic effect of the sprays of the embodiments and comparative examples on allergic rhinitis

[0058] Sprays Significantly effective (example) Valid (Example) Invalid (Example) Effectiveness (%) Example 1 25 4 1 96.7 Example 2 24 6 0 100 Example 3 26 4 0 100 Comparative Example 1 14 8 8 73.3 Comparative Example 2 12 8 10 66.7

[0059] As shown in Tables 1 to 3, the Chinese medicine spray of the present invention has an excellent antibacterial rate and has a significant effect on allergic rhinitis, with an effective rate of more than 96.7%. The present invention significantly improves the antibacterial and anti-inflammatory effects of the Chinese medicine spray and the rhinitis treatment effect by reasonably selecting each raw material and controlling the dosage of each raw material. It can be seen from the effects of the embodiments and comparative examples that changing the raw materials or dosage of the present invention will lead to a decrease in the antibacterial and anti-inflammatory effects of the spray and the rhinitis treatment effect.

[0060] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine spray containing agarwood, characterized in that: The traditional Chinese medicine spray contains traditional Chinese medicine extracts; the traditional Chinese medicine extracts contain the following raw materials in parts by weight: 5-10 parts of agarwood, 10-20 parts of mugwort, 20-30 parts of magnolia, 5-10 parts of rockberry tea, 8-12 parts of Xanthium sibiricum, 5-10 parts of Veratrum, 8-12 parts of galangal, 5-10 parts of calamus, and 2-4 parts of borneol.

2. The Chinese medicine spray containing agarwood according to claim 1, characterized in that: The Chinese medicine extract comprises the following raw materials in parts by weight: 6-9 parts of agarwood, 12-18 parts of mugwort, 22-28 parts of magnolia, 6-9 parts of rockberry tea, 9-11 parts of Xanthium sibiricum, 9-11 parts of Veratrum, 6-9 parts of galangal, 6-9 parts of calamus, and 3 parts of borneol.

3. The Chinese medicine spray containing agarwood according to claim 1 or 2, characterized in that: The traditional Chinese medicine spray also contains auxiliary materials, which are water and glycerin.

4. The Chinese medicine spray containing agarwood according to claim 3, characterized in that: The volume ratio of water to glycerol is 10:2-3.

5. The method for preparing the Chinese medicine spray containing agarwood according to any one of claims 1 to 4, characterized in that: The following steps are included: 1) mixing agarwood, wormwood leaf, magnolia, cyperus rotundus, Xanthium sibiricum, Veratrum, ginger, Acorus calamus and borneol, and then grinding them into mixed powder, adding water to the mixed powder for decoction, combining the extracts, and concentrating them to obtain a Chinese medicine extract; 2) The Chinese medicine extract and the auxiliary materials are mixed to obtain a Chinese medicine spray containing agarwood.

6. The preparation method according to claim 5, characterized in that: The temperature of the decoction extraction is 90-100° C., and the number of decoction extractions is 2-3 times.

7. The preparation method according to claim 5 or 6, characterized in that: The time for each decoction and extraction is 40 to 60 minutes. In each decoction and extraction, the mass ratio of the mixed powder to water is 1:6 to 10.

8. The preparation method according to claim 5, characterized in that: The mass ratio of the traditional Chinese medicine extract to the auxiliary material is 1-2:

10.

9. Use of the traditional Chinese medicine spray containing agarwood as described in any one of claims 1 to 4 in the nasal cavity.

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