Traditional Chinese medicine composition for treating phlegm-damp heat transforming type femoral head necrosis as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for treating phlegm-dampness and heat-transforming type femoral head necrosis as well as a preparation method and application of the traditional Chinese medicine composition, which can effectively solve the medication problem of phlegm-dampness and heat-transforming type ulcerative femoral head necrosis. The traditional Chinese medicine is prepared from, by weight, 10-20 g of poria cocos, 10-20 g of coix seeds, 6-12 g of rhizoma alismatis, 14-26 g of Chinese yam, 8-16 g of capillary artemisia, 8-16 g of rhizoma dioscoreae septemlobae, 10-20 g of radix paeoniae rubra, 6-12 g of rhizoma atractylodis, 6-14 g of pericarpium citri reticulatae, 6-14 g of rhizoma pinelliae preparata, 6-12 g of vinegar rhizoma sparganii, 6-12 g of vinegar curcuma zedoary, 8-16 g of eucommia ulmoides, 4-8 g of liquorice, 6-12 g of rhizoma anemarrhenae, 6-12 g of cortex phellodendri, 8-16 g of fructus psoraleae and 6-14 g of radix achyranthis bidentatae. The traditional Chinese medicine composition is scientific in preparation, has the effects of warming kidney yang, clearing damp and tonifying spleen, has a remarkable effect of treating the phlegm-damp heat type femoral head necrosis, has a good long-term curative effect, is not easy to relapse, is easily accepted by patients, and is an innovation of medicines for treating the phlegm-damp heat type femoral head necrosis.

Description

1. Technical Field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating phlegm-dampness-heat-transforming femoral head necrosis and a preparation method and application thereof. 2. Background Technology

[0002] Femoral head necrosis is a common clinical orthopedic disease. It is difficult to treat and disabling. It is a pathological evolution process. It often starts in the weight-bearing area of ​​the femoral head. Under the action of force, the necrotic bone structure is damaged, resulting in repeated imperfect repair, resulting in changes in the femoral head structure or collapse and deformation. Femoral head necrosis will cause severe pain and joint mobility dysfunction in patients. Common clinical symptoms include pain, which is mostly located in the hip joint and proximal thigh, resulting in limited hip movement, especially limited rotational movement, or painful and shortened claudication, which seriously endangers the patient's quality of life and even life safety. The current incidence of ONFH is increasing year by year, seriously affecting the quality of life of patients and bringing a considerable economic burden to their families. Studies have shown that patients with ONFH who have not been effectively treated will experience femoral head collapse within 1 to 5 years of onset, which directly affects the function of the hip joint, and ultimately can only be improved through joint replacement surgery. At present, hip preservation treatment is mainly adopted for early and middle-stage ONFH at home and abroad to stabilize the morphology of the femoral head and delay collapse, thereby delaying the time for hip replacement surgery.

[0003] Femoral head necrosis belongs to the category of "bone atrophy" and "bone failure" in traditional Chinese medicine. "The kidney governs bones, the liver governs tendons, and bones produce marrow." Traditional Chinese medicine believes that the main causes of this disease are liver and kidney deficiency, insufficient qi and blood, lack of nourishment to tendons and bones, joint strain, cold and dampness, and blood stasis. The root cause of this disease is liver and kidney deficiency. This disease is prone to recurrence. For this reason, traditional Chinese medicine treatment advocates that this disease is mostly due to deficiency in the root and excess in the superficial, with liver and kidney deficiency and spleen and stomach dysfunction. The kidney-tonifying and bone-strengthening method has the effect of nourishing the liver and kidney and strengthening tendons and bones, which can effectively improve the symptoms of such patients. Chinese herbal decoctions can improve the Harris and JOA scores of patients with femoral head ischemic necrosis, relieve their pain, and are safer. Traditional Chinese medicine conservative treatment has unique therapeutic advantages in preventing and treating femoral head necrosis, and has an improving effect on blood rheology and blood lipids. We believe that the pathogenesis of femoral head necrosis is not single, and it is related to multiple organs such as liver, kidney, spleen, bladder, etc., but it is most closely related to liver and kidney. Kidney governs bones, and bone diseases are treated from the perspective of kidney. It is in line with the theory of traditional Chinese medicine to take kidney tonification as the fundamental treatment goal to strengthen tendons and bones. However, patients with phlegm-dampness turning into heat are also part of the treatment in clinical work, but there are few existing studies. In view of this, the inventors proposed phlegm-dampness turning into heat type femoral head necrosis, and invented a Chinese medicine composition for treating phlegm-dampness turning into heat type femoral head necrosis, as well as its preparation method and use. III. Summary of the invention

[0004] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating phlegm-dampness-heat type femoral head necrosis and its preparation method and application, which can effectively solve the medication problem of phlegm-dampness-heat type ulcerative femoral head necrosis.

[0005] The inventor found that the body shape of the TCM syndrome of phlegm-dampness turning into heat is often obese, the face and nose tip are often oily, the face is prone to acne, the skin is prone to itching, sweating, often feeling bitter in the mouth, bad breath, bad smell in the mouth, sticky and smelly stool, hot feeling in urine, yellow urine, and irritability. The tongue is reddish, the tongue coating is yellow and greasy, and the pulse is often slippery and rapid.

[0006] Based on this, the technical solution solved by the present invention is a traditional Chinese medicine composition for treating femoral head necrosis of phlegm-dampness-heat type, which is made of the following raw materials by weight: 10-20g of Poria cocos, 10-20g of Coix seed, 6-12g of Alisma orientalis, 14-26g of Dioscorea opposita, 8-16g of Artemisia capillaris, 8-16g of Cyathula capitata, 10-20g of Red Peony Root, 6-12g of Atractylodes macrocephala, 6-14g of Citrus reticulata, 6-14g of Pinellia ternata, 6-12g of Vinegar Trillium, 6-12g of Vinegar Curcuma, 8-16g of Eucommia ulmoides, 4-8g of Licorice, 6-12g of Anemarrhena asphodeloides, 6-12g of Phellodendron chinense, 8-16g of Psoralea corylifolia, and 6-14g of Achyranthes bidentata.

[0007] Preferably, the Chinese medicine composition is made of the following raw materials by weight: 15g Poria, 15g Coix seed, 9g Alisma, 20g Dioscorea, 12g Artemisia Capillaris, 12g Trichosanthes, 15g Red Peony Root, 9g Atractylodes, 10g Tangerine Peel, 10g Pinellia, 9g Vinegar Trigonosciadium, 9g Vinegar Curcuma, 12g Eucommia, 6g Licorice, 9g Anemarrhena, 9g Phellodendron, 12g Psoralea, and 10g Achyranthes.

[0008] Furthermore, the Chinese medicine composition can be prepared into pills, tablets, decoctions, granules and capsules.

[0009] Furthermore, the decoction preparation method is as follows: add 400-600 ml of water to the above-mentioned raw material drugs, soak for 15-25 minutes at 18-25°C, then boil over high heat, then turn to low heat, boil for 20-30 minutes, filter, obtain filtrate, and set aside; add 300-400 ml of water to the residue, boil over high heat, then turn to low heat, boil for 10-15 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 2-1 / 3 of the amount of water added twice.

[0010] Furthermore, the Chinese medicine composition is used in the preparation of a drug for treating phlegm-dampness-heat type femoral head necrosis.

[0011] The invention has abundant raw materials, simple preparation method, effective combination of prescription drugs, mutual support, and scientific preparation, and has the effects of warming kidney yang, removing dampness and strengthening spleen. It has significant effect in treating femoral head necrosis of phlegm-dampness-heat type, and has good long-term efficacy, is not easy to recur, and is easily accepted by patients. It is an innovation in drugs for treating femoral head necrosis of phlegm-dampness-heat type. IV. Description of the drawings

[0012] Figure 1 These are the results of the in vitro cell experiments of the present invention. V. Specific implementation methods

[0013] The specific implementation modes of the present invention are further described in detail below in conjunction with the embodiments.

[0014] Example 1

[0015] When the present invention is implemented, the Chinese medicine soup can be prepared from the following raw materials by weight: 10g of Poria, 10g of Coix seed, 6g of Alisma, 14g of Dioscorea, 8g of Artemisia Capillaris, 8g of Herba Cynomorii, 10g of Paeonia lactiflora, 6g of Atractylodes, 6g of Tangerine Peel, 6g of Pinellia Ternatea, 6g of Vinegar Trillium, 6g of Vinegar Curcuma, 8g of Eucommia, 4g of Licorice, 6g of Anemarrhena, 6g of Phellodendron, 8g of Psoralea corylifolia, and 6g of Achyranthes bidentata.

[0016] The preparation method is as follows: add 400 ml of water to the above raw material drugs, soak for 15 minutes at 18°C, then boil over high heat, then turn to low heat, boil for 20 minutes, filter, obtain filtrate, and set aside; add 300 ml of water to the residue, boil over high heat, then turn to low heat, boil for 10 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 2 of the amount of water added twice.

[0017] Example 2

[0018] When the present invention is implemented, the Chinese medicine soup can also be made from the following raw materials by weight: 15g of Poria, 15g of Coix seed, 9g of Alisma, 20g of Dioscorea, 12g of Artemisia Capillaris, 12g of Herba Polygoni Multiflori, 15g of Paeonia lactiflora, 9g of Atractylodes, 10g of Citrus reticulata, 10g of Pinellia ternata, 9g of Vinegar Trillium, 9g of Vinegar Curcuma, 12g of Eucommia, 6g of Licorice, 9g of Anemarrhena, 9g of Phellodendron, 12g of Psoralea corylifolia, and 10g of Achyranthes bidentata.

[0019] The preparation method is as follows: add 500 ml of water to the above raw material drugs, soak for 20 minutes at 21°C, then boil over high heat, then turn to low heat, boil for 25 minutes, filter, obtain filtrate, and set aside; add 350 ml of water to the residue, boil over high heat, then turn to low heat, boil for 12 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 3 of the amount of water added twice.

[0020] Example 3

[0021] When the present invention is implemented, the Chinese medicine soup can also be made from the following raw materials by weight: it is made from the following raw materials by weight: 20g of Poria, 20g of Coix Seed, 12g of Alisma, 26g of Dioscorea, 16g of Artemisia Capillaris, 16g of Cyathula capitata, 20g of Red Peony Root, 12g of Atractylodes, 14g of Tangerine Peel, 14g of Pinellia Ternate, 12g of Vinegar Trillium, 12g of Vinegar Curcuma, 16g of Eucommia, 8g of Licorice, 12g of Anemarrhena, 12g of Phellodendron, 16g of Psoralea corylifolia, and 14g of Achyranthes bidentata.

[0022] The preparation method is as follows: add 600 ml of water to the above raw material drugs, soak for 25 minutes at 25°C, then boil over high heat, then turn to low heat, boil for 30 minutes, filter, obtain filtrate, and set aside; add 400 ml of water to the residue, boil over high heat, then turn to low heat, boil for 15 minutes, filter, discard the residue, obtain filtrate, combine the two filtrates, and concentrate to 1 / 2 of the amount of water added twice.

[0023] In the prescription of the present invention:

[0024] Poria cocos tastes sweet and mild, and is neutral in nature. It enters the spleen, kidney, heart, and lung meridians. It strengthens the spleen and calms the heart, and promotes diuresis and eliminates dampness.

[0025] Coix seeds are sweet, light, and cool in nature. They enter the spleen, stomach, and lung meridians. They can promote diuresis and eliminate dampness, strengthen the spleen and stop diarrhea, and eliminate numbness.

[0026] Alisma orientalis is sweet and light in taste, and cold in nature. It enters the kidney and bladder meridians. It can promote diuresis, dissipate dampness, relieve heat, clear turbidity and reduce fat.

[0027] Chinese yam is sweet and neutral in nature. It enters the spleen, lung and kidney meridians. It has the functions of replenishing qi and nourishing yin, tonifying spleen, lung and kidney, consolidating essence and stopping leukorrhea.

[0028] Artemisia capillaris tastes bitter and pungent, and is slightly cold in nature. It enters the spleen, stomach, liver, and gallbladder meridians. It clears away heat and dampness, promotes bile secretion, and relieves jaundice.

[0029] Herba Dioscoreae is bitter in taste and neutral in nature. It enters the kidney and stomach meridians. It can remove dampness, turbidity, wind and numbness.

[0030] Red peony root is bitter and cold in nature. It enters the liver meridian. It clears away heat, cools blood, disperses blood stasis and relieves pain.

[0031] Atractylodes lancea tastes pungent and bitter, and is warm in nature. It enters the spleen and stomach meridians. It dries dampness, strengthens the spleen, and eliminates filth and turbidity.

[0032] Tangerine peel tastes bitter and spicy, and is warm in nature. It enters the spleen and lung meridians. It regulates qi and strengthens the spleen, dries dampness and resolves phlegm.

[0033] Pinellia tuber is pungent in taste and warm in nature. It enters the spleen, stomach and lung meridians. It dries dampness and resolves phlegm, relieves adverse reactions and stops vomiting, and eliminates lumps and resolves lumps.

[0034] Vinegar Trigonum multiflorum tastes bitter and is neutral in nature. It enters the liver and spleen meridians. It can promote blood circulation, relieve swelling and relieve pain.

[0035] Vinegar Curcuma Atractylodes tastes pungent and bitter, and is warm in nature. It enters the liver, spleen, and stomach meridians. It promotes qi and resolves blood, eliminates stagnation, and relieves pain.

[0036] Eucommia ulmoides is sweet and warm in nature. It enters the liver and kidney meridians. It nourishes the liver and kidneys and strengthens the tendons and bones.

[0037] Licorice root is sweet and neutral in nature. It enters the spleen, stomach, heart and lung meridians. It nourishes the spleen and replenishes qi, relieves pain and harmonizes various medicines.

[0038] Anemarrhena is bitter in taste and cold in nature. It enters the lung, stomach and kidney meridians. It clears away heat and purges fire, nourishes yin and moistens dryness, quenches thirst and relieves restlessness.

[0039] Phellodendron chinense is bitter in taste and cold in nature. It enters the kidney and bladder meridians. It clears away heat and dampness, relieves fire and relieves restlessness, detoxifies and treats sores.

[0040] Psoralea corylifolia tastes pungent and bitter, and is warm in nature. It enters the spleen and kidney meridians. It nourishes the kidney and strengthens yang, warms the spleen and stops diarrhea, consolidates semen and reduces urine.

[0041] Achyranthes bidentata tastes sweet and slightly bitter, and is neutral in nature. It enters the liver and kidney meridians. It nourishes the liver and kidneys, strengthens tendons and bones, removes blood stasis, dredges the meridians, and guides blood downward.

[0042] The effective combination of the above drugs supports each other and is scientifically prepared to have the function of clearing heat and removing dampness. In the prescription, Poria cocos and Coix seed are the main drugs for strengthening the spleen, promoting diuresis and removing dampness. Alisma orientalis is good at relieving heat and can enhance the effect of promoting diuresis and removing dampness; Chinese yam nourishes the spleen and lungs, nourishes the kidneys and consolidates essence, and can alleviate the side effects of damaging body fluids caused by diuretic and dampness-removing drugs; Artemisia capillaris, Codonopsis pilosula, Anemarrhena asphodeloides, and Phellodendron chinense clear dampness and heat, and enhance the effect of the prescription in clearing dampness and heat; Red peony root clears heat and cools blood, disperses blood stasis and relieves pain, and can assist drugs that clear dampness and heat, and at the same time has a certain effect on relieving pain caused by blood stasis; Eucommia ulmoides, Psoralea corylifolia, and Achyranthes bidentata nourish the liver and kidneys, strengthen tendons and bones, and can counteract the damage to body fluids caused by diuretic and dampness-removing drugs; they are all ministerial drugs, enhancing the effect of clearing heat and removing dampness. Atractylodes lancea, dried tangerine peel, and Pinellia ternata strengthen the spleen and dry dampness, which not only strengthens the spleen and regulates qi, but also can resolve phlegm; Vinegar Trillium and Vinegar Curcuma enhance the effect of promoting blood circulation and relieving pain; they are all adjuvant drugs. Licorice harmonizes all the medicines, and also has the functions of harmonizing the middle and replenishing qi, clearing away heat and detoxifying. The compatibility of the whole prescription takes into account multiple aspects such as strengthening the spleen, removing dampness, clearing heat, activating blood circulation, and tonifying the kidney. The mutual compatibility is effective in treating phlegm-dampness-heat type femoral head necrosis, and has achieved very good beneficial technical effects through experiments. The relevant experimental data are as follows:

[0043] 1Case Source

[0044] This study selected 60 patients with femoral head necrosis of phlegm-dampness-heat type who visited the inpatient department of osteonecrosis at Luoyang Orthopedic Hospital of Henan Province from January 2022 to October 2023 as the research subjects.

[0045] 2 Diagnostic criteria

[0046] The diagnostic criteria were developed based on the 2012 edition of the Expert Consensus on Diagnosis and Treatment Standards for Femoral Head Necrosis in Adults.

[0047] (1) Clinical symptoms, signs and medical history: joint pain mainly in the groin, buttocks and thighs, occasionally accompanied by knee pain, limited hip flexion, internal rotation and external rotation, often with a history of hip trauma, corticosteroid use, alcoholism and occupational history such as diving;

[0048] (2) X-ray changes: In the early stage of femoral head necrosis, the femoral head will show increased density (sclerosis) and translucent areas (cystic changes); as the disease progresses, a typical crescent sign will appear; in the late stage, the femoral head may collapse, the joint space may narrow, and severe bone and joint changes may occur, with sclerosis and cystic changes in the acetabulum being common;

[0049] (3) CT scan changes: sclerotic bands surrounding necrotic bone, repaired bone, or subchondral bone fractures can be seen in the femoral head;

[0050] (4) MRI signs: T1WI shows a band-like low signal in the necrotic area or T2WI shows a double-line sign;

[0051] (5) Radionuclide bone scan: In the early stage of necrosis, there is a perfusion defect (cold area); as the disease progresses, there is a cold area in the hot area, which is a "doughnut-like" change;

[0052] (6) Bone biopsy: showed that the empty pits of osteocytes in trabeculae accounted for more than 50% and involved multiple adjacent trabeculae, with bone marrow necrosis.

[0053] The diagnosis can be confirmed if two or more of the above six criteria are met. Except for (1) and (5), the diagnosis can be confirmed if one of (2, 3, 4, 6) is met.

[0054] 3 The staging criteria are based on the 2019 Association Research Circulation Osseuse (ARCO) osteonecrosis staging criteria, as shown in Table 1.

[0055] Table 1 ARCO staging of femoral head necrosis

[0056]

[0057] The body is often obese, the face and nose are often oily, the face is prone to acne, the skin is prone to itching, sweating, often bitter taste in the mouth, bad breath, bad breath, the stool is often sticky and smelly, the urine feels hot and yellow, and the temper is easy to be irritable. The tongue is reddish, the coating is yellow and greasy, and the pulse is often slippery and rapid.

[0058] 4 Inclusion criteria

[0059] (1) Meet the diagnostic criteria for femoral head necrosis;

[0060] (2) those receiving conservative treatment;

[0061] (3) The primary disease is cured or in a stable stage;

[0062] (4) Those who are not accompanied by bone metabolic diseases, ankylosing spondylitis, bone tumors, various arthritis and other bone diseases;

[0063] (5) Be at least 18 years old and have the capacity to act independently;

[0064] (6) Patients who voluntarily participate in clinical research and sign the informed consent form.

[0065] 5 Exclusion criteria

[0066] (1) The primary disease has not been effectively controlled or is in the active stage;

[0067] (2) Patients with femoral head necrosis who refuse conservative treatment;

[0068] (3) Patients with other internal and external diseases other than the primary disease who require long-term medication;

[0069] (4) Pregnant or lactating women;

[0070] (5) Those who are currently participating in clinical trials of other drugs;

[0071] (6) Those who dropped out of the study or were lost to follow-up due to various reasons.

[0072] 6 Research Groups

[0073] The patients were numbered from 1 to 60 according to the order of their visits, and random numbers were generated using SPSS27.0. The patients were randomly divided into a treatment group and a control group according to the principle of random grouping, with 30 cases in each group.

[0074] 7. Medication

[0075] Treatment duration: 12 weeks

[0076] Control group: Xianling Gubao.

[0077] Treatment group: Xianling Gubao (specific usage is the same as the control group) combined with the Chinese medicine soup prepared in Example 2 of the present invention, 200 ml each time, once in the morning and once in the evening.

[0078] 8. Efficacy evaluation criteria

[0079] Harris score of hip joint function and visual analogue scale (VAS pain score) were observed in the two groups before treatment and 12 weeks after treatment, and the differences between the two groups before and after treatment were compared and analyzed.

[0080] 9 Clinical efficacy evaluation

[0081] After treatment, the P values ​​of Harris score and VAS pain score were less than 0.05, and the difference between the two groups was statistically significant. The therapeutic effect of the treatment group was better than that of the control group. The clinical efficacy evaluation is shown in Table 2.

[0082] Table 2 Comparison of Harris score and VAS pain score

[0083]

[0084] 10 In vitro cell experiments

[0085] Twelve 4-week-old SD rats were randomly divided into two groups, a control group and an experimental group. The control group was given Xianlinggubao solution by gavage, and the experimental group was given a mixture of Xianlinggubao and Chinese medicine decoction by gavage once a day for a total of 14 days. Two hours after the last gavage intervention, the abdominal aorta blood of the rats was collected, centrifuged, inactivated, sterilized, and packaged, and the serum was stored at -20℃ for later use.

[0086] Four SD rats were anesthetized with 20% urethane and then killed. The femoral and tibia bone marrow of the rats were removed for BMSCs culture. The cells were passaged when the confluence reached 80% to 90%, and the cell morphology and growth were observed under an inverted microscope. The third-generation rat BMSCs were made into a single cell suspension, and the cells were inoculated into a 6-well plate and divided into a control group and an experimental group. The control group was cultured with an osteogenic induction agent containing rat serum containing Xianling Gubao, and the experimental group was cultured with an osteogenic induction agent containing rat serum containing Xianling Gubao and Chinese herbal decoctions. After 21 days of culture, alizarin red staining was performed to observe the cell osteogenesis. The results showed that the formation and deposition of extracellular mineralized nodules occurred in all groups, among which the experimental group had a larger positive staining area and obvious mineralized nodules. This suggests that Chinese herbal decoctions can enhance the osteogenic differentiation of BMSCs (such as Figure 1 shown).

[0087] 11. Safety Assessment

[0088] No adverse reactions occurred in the 60 patients during the treatment period, and no obvious abnormalities were found in vital signs, blood routine, urine routine, stool routine, electrocardiogram, liver and kidney function, and coagulation function after taking the medicine, indicating that the Chinese medicine of the present invention has good safety.

[0089] After repeated tests and practices, other embodiments all obtained the same or similar test results as Embodiment 2, which will not be described in detail one by one.

[0090] 12 Conclusion

[0091] It can be seen from the above that the present invention has abundant raw materials, simple preparation method, easy to take, low cost, good effect, and the components support each other. It has the effects of warming the kidney yang and tending to strengthen the spleen. The whole prescription not only has stable efficacy, but also good long-term efficacy, is not easy to recur, and is easily accepted by patients. It is effectively used to treat phlegm-dampness-heat type femoral head necrosis. The Chinese medicine soup of the present invention, which is characterized by simplicity, convenience, low cost and effectiveness, not only conforms to the pathogenesis of femoral head necrosis, but also conforms to the theory of warming and tonifying the spleen and kidney in traditional Chinese medicine. It is an innovation in drugs for treating femoral head necrosis, and has huge economic and social benefits.

[0092] It should be pointed out that the above is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any technician familiar with the profession can make changes or modify the technical contents disclosed above into equivalent embodiments with equivalent changes without departing from the scope of the technical solution of the present invention, which all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating phlegm-dampness-heat type femoral head necrosis, characterized in that: It is made from the following raw materials by weight: Poria 10-20g, Coix seed 10-20g, Alisma 6-12g, Dioscorea opposita 14-26g, Artemisia capillaris 8-16g, Herba Cynomorii 8-16g, Paeonia lactiflora 10-20g, Atractylodes 6-12g, Tangerine peel 6-14g, Pinellia 6-14g, Vinegar Trillium 6-12g, Vinegar Curcuma 6-12g, Eucommia 8-16g, Licorice 4-8g, Anemarrhena asphodeloides 6-12g, Phellodendron chinense 6-12g, Psoralea corylifolia 8-16g, Achyranthes bidentata 6-14g.

2. The Chinese medicine composition for treating phlegm-dampness-heat type femoral head necrosis according to claim 1, characterized in that: It is made from the following raw materials by weight: 15g of Poria cocos, 15g of Coix seed, 9g of Alisma orientalis, 20g of Dioscorea opposita, 12g of Artemisia capillaris, 12g of Cynomorium wilfordii, 15g of Paeonia lactiflora, 9g of Atractylodes macrocephala, 10g of Citrus reticulata, 10g of Pinellia ternata, 9g of Vinegar Trillium, 9g of Vinegar Curcuma, 12g of Eucommia ulmoides, 6g of Licorice, 9g of Anemarrhena asphodeloides, 9g of Phellodendron amurense, 12g of Psoralea corylifolia, and 10g of Achyranthes bidentata.

3. The method for preparing the Chinese medicine composition for treating phlegm-dampness-heat type femoral head necrosis according to claim 1 or 2, characterized in that: The drug is mixed with medically acceptable auxiliary materials and prepared into pills, tablets, decoctions, granules and capsules according to conventional preparation methods.

4. The method for preparing the Chinese medicine composition for treating phlegm-dampness-heat-type femoral head necrosis according to claim 3, characterized in that: The decoction preparation method comprises the following steps: adding 400-600 ml of water to all raw medicines, soaking them at 18-25°C for 15-25 minutes, then boiling them over high heat, then decocting them over low heat for 20-30 minutes, filtering them, and obtaining a filtrate for later use; adding 300-400 ml of water to the filter residue, boiling them over high heat, then decocting them over low heat for 10-15 minutes, filtering them, discarding the filter residue, obtaining a filtrate, combining the two filtrates, and concentrating them to 1 / 2-1 / 3 of the amount of water added twice.

5. Use of the Chinese medicine composition for treating phlegm-dampness-heat type femoral head necrosis according to claim 1 or 2 in the preparation of drugs for treating phlegm-dampness-heat type femoral head necrosis.

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