Dry formulations of active ingredients

Abstract

Described herein is a dry agrochemical formulation, such as a water dispersible particle (WG) or a wettable powder (WP), for an active ingredient having a relatively low melting temperature, such as bifenthrin. The dry formulations provide high active ingredient loading, excellent dispersibility, and excellent storage stability.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Application No. 63 / 411,318, filed on September 29, 2022. Technical Field

[0003] The present disclosure relates to a dry agrochemical formulation, such as water dispersible granules (WG) or wettable powders (WP), for active ingredients with relatively low melting temperatures, such as bifenthrin. The dry formulation provides high active ingredient loading, excellent dispersibility and excellent storage stability. Background Art

[0004] Dry agricultural chemical formulations deliver active ingredients in dry form, and have advantages over liquid formulations in terms of being easy to measure and distribute products and reducing transportation costs. When the active ingredient of concern has a low melting point (typically less than 80° C.), formulation challenges are created, and there are several factors that cause these difficulties. The processing temperature of dry formulation processes (such as grinding, extrusion and drying) is usually close to or exceeds the melting point of the active ingredient. At such a temperature, the active ingredient will melt or soften, and cause the material to adhere or agglomerate to itself, other materials in the formulation or equipment, resulting in poor product physical stability and difficulty in processing.

[0005] Owing to being difficult to ensure the storage stability of this product, the dry preparation of low-melting active ingredient has other challenge.Extend storage condition, especially if being exposed to the high temperature higher than ambient temperature, also may promote the softening or movement of active ingredient, thereby cause undesirable material interaction or reunion and cause product to disperse or suspend poor when using according to instructions.Like this, the dry preparation with low-melting active ingredient typically has the active ingredient of limited quantity and concentration, to ensure physical stability and the processability of preparation.In order to prepare stable and processable dry preparation, particularly when attempting to prepare with higher active ingredient concentration, may also need other non-obvious formulation method.

[0006] It has surprisingly been discovered in the present disclosure that dry agrochemical formulations containing high loadings of low melting active ingredients and having excellent storage stability and processability can be prepared using specific flow aids or anti-caking agents. Summary of the invention

[0007] In one aspect, the present invention provides a dry composition comprising: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to 2 wt % of a defoaming agent; and about 55 wt % to about 90 wt % of a diluent.

[0008] On the other hand, the present invention provides a method for preparing a dry composition, which comprises: (i) forming a mixture, the mixture comprising: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to 2 wt % of a defoaming agent; and about 55 wt % to about 90 wt % of a diluent; (ii) grinding the mixture; (iii) optionally wetting the mixture with water; (iv) optionally kneading the mixture wetted with water; (v) optionally extruding the mixture wetted with water; and (vi) optionally drying the mixture.

[0009] On the other hand, the present invention provides a method of using a dry composition, which comprises: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to 2 wt % of a defoamer; and about 55 wt % to about 90 wt % of a diluent; the method includes using the dry composition to control pests. DETAILED DESCRIPTION

[0010] Described herein is a dry formulation, such as a water dispersible granule (WG) or wettable powder (WP), for an active ingredient with a relatively low melting temperature. In particular, a high loading (10-30 wt%) of bifenthrin WG formulation is described herein. The high loading of bifenthrin is achieved with a flow aid or anti-caking agent based on silica.

[0011] In many embodiments, the dry composition comprises: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to 2 wt % of a defoaming agent; and about 55 wt % to about 90 wt % of a diluent.

[0012] In many embodiments, the active ingredient comprises a pesticide. In many embodiments, the active ingredient is a pesticide.

[0013] Generally, the pesticide may include any suitable pesticide known in the art in any amount. In some embodiments, the pesticide is selected from insecticides, herbicides, nematicides, biopesticides, fungicides, and combinations thereof. In some embodiments, the pesticide is selected from bifenthrin, crystalline bifenthrin, waxy bifenthrin, amorphous bifenthrin, kappa-bifenthrin, and combinations thereof, and the pesticide has a melting point in the range of about 50°C to about 90°C.

[0014] In many embodiments, the melting point of the active ingredient is a critical feature for these compositions.Formulating active ingredients with a melting point of less than 80°C is particularly challenging, especially as a dry formulation.

[0015] In some embodiments, the active ingredient has a melting point of less than about 100°C. In some embodiments, the active ingredient has a melting point of less than about 80°C. In some embodiments, the active ingredient has a melting point in the range of about 50°C to about 100°C. In some embodiments, the active ingredient has a melting point in the range of about 50°C to about 90°C. In some embodiments, the active ingredient has a melting point in the range of about 50°C to about 80°C.

[0016] In many embodiments, the active ingredient is present in high strength. In some embodiments, the active ingredient is present in an amount of at least about 10wt%, at least about 11wt%, at least about 12wt%, at least about 13wt%, at least about 14wt%, at least about 15wt%, at least about 16wt%, at least about 17wt%, at least about 18wt%, at least about 19wt%, at least about 20wt%, at least about 21wt%, at least about 22wt%, at least about 23wt%, at least about 24wt%, at least about 25wt%, at least about 26wt%, at least about 27wt%, at least about 28wt%, at least about 29wt%, or at least about 30wt%.

[0017] In some embodiments, the active ingredient is present in an amount ranging from about 10wt% to about 30wt%. In some embodiments, the active ingredient is present in an amount ranging from about 15wt% to about 30wt%. In some embodiments, the active ingredient is present in an amount ranging from about 25wt% to about 30wt%. In some embodiments, the active ingredient is present in an amount ranging from about 20wt% to about 30wt%. In some embodiments, the active ingredient is present in an amount ranging from about 20wt% to about 25wt%. In some embodiments, the active ingredient is present in an amount ranging from about 25wt% to about 30wt%.

[0018] In some embodiments, the active ingredient is present in an amount ranging from about 20 wt% to about 30 wt%.

[0019] Generally, the wetting agent can be selected from any suitable wetting agent known in the art. In some embodiments, the wetting agent is selected from alkylnaphthalene sulfonates, lauryl sulfate, Stepanol ME Dry, dodecylbenzene sulfonates, sulfosuccinates, Aerosol OT B, Geropon SDS, and combinations thereof.

[0020] In some embodiments, the dry composition comprises from about 0.5 wt% to about 1.5 wt% of a wetting agent. In some embodiments, the dry composition comprises from about 0.5 wt% to about 1.0 wt% of a wetting agent. In some embodiments, the dry composition comprises from about 1.0 wt% to about 1.5 wt% of a wetting agent.

[0021] Typically, the binder can be selected from any suitable binder known in the art. In some embodiments, the binder is selected from sugar, monosaccharide, glucose, dextrose, fructose, disaccharide, sucrose, lactose, lactose monohydrate, maltose, polysaccharide, starch, microcrystalline cellulose, chitin, and combinations thereof.

[0022] In some embodiments, the dry composition comprises from about 0 wt % to about 20 wt % of a binder. In some embodiments, the dry composition comprises from about 0 wt % to about 6 wt % of a binder. In some embodiments, the dry composition comprises from about 0 wt % to about 3 wt % of a binder.

[0023] Typically, the flow aid or anti-caking agent can be selected from any suitable flow aid or anti-caking agent known in the art. Non-limiting examples include Hi Sil SAC, Hi Sil ABS, Hi Sil 233, Aerosil 200, Aerosil 300, Aerosil R972, Aerosil R974, Cab-o-sil M5, Cab-o-sil H5, Cab-o-sil TS-610, Cab-o-sil TS 530, Cab-o-sil TS-720, Sipernat 22S, Zeofree 5161, Sipernat50S, Sipernat340, and combinations thereof. In some embodiments, the flow aid or anti-caking agent is selected from fumed silica, Cab-o-sil M5, Aerosil 200, Aerosil 300, precipitated silica, Hi-Sil SAC, Hi-Sil ABS, Hi Sil 233, flow aids, magnesium silicate monohydrate (talc), magnesium stearate, calcium silicate, sodium aluminum silicate, microcrystalline cellulose, and combinations thereof.

[0024] In some embodiments, the dry composition comprises about 0.5wt% to about 30wt% of a flow aid or anti-caking agent. In some embodiments, the dry composition comprises about 0.5wt% to about 15wt% of a flow aid or anti-caking agent. In some embodiments, the dry composition comprises about 0.5wt% to about 6wt% of a flow aid or anti-caking agent. In some embodiments, the dry composition comprises about 0.5wt% to about 3wt% of a flow aid or anti-caking agent.

[0025] Typically, the dispersant can be selected from any suitable dispersant known in the art. Non-limiting examples include Geropon TA 72, Geropon T36, Geropon T 77, Geropon SC 213, Metasperse 550S, Reax85A, and combinations thereof. In certain embodiments, the dispersant is selected from acrylic polymer dispersants, polycarboxylic acid polymer dispersants, Geropon TA72, Geropon T36, Geropon SC 213, lignin sulfonate, sodium methyl oleoyl taurate, and combinations thereof.

[0026] In some embodiments, the dry composition comprises about 1.0 wt% to about 5.0 wt% of a dispersant. In some embodiments, the dry composition comprises about 1.0 wt% to about 3.0 wt% of a dispersant. In some embodiments, the dry composition comprises about 2.0 wt% to about 3.0 wt% of a dispersant.

[0027] Generally, the defoaming agent can be selected from any suitable defoaming agent known in the art. In some embodiments, the defoaming agent is selected from tallow-based defoaming agents, silicone-based defoaming agents, glycol-based defoaming agents, and combinations thereof.

[0028] In some embodiments, the dry composition comprises from about 0 wt% to about 2 wt% of an antifoaming agent. In some embodiments, the antifoaming agent is optional.

[0029] Typically, the diluent can be selected from any suitable diluent known in the art. In some embodiments, the diluent is selected from talc, starch, microcrystalline cellulose, kaolin, kaolin (barden) clay, suprex clay, ASP 400, sugars, monosaccharides, glucose, dextrose, fructose, disaccharides, sucrose, lactose, lactose monohydrate, maltose, polysaccharides, starch, microcrystalline cellulose, chitin, and combinations thereof.

[0030] In some embodiments, the dry composition comprises about 55wt% to about 90wt% of a diluent. In some embodiments, the dry composition comprises about 55wt% to about 80wt% of a diluent. In some embodiments, the dry composition comprises about 55wt% to about 70wt% of a diluent. In some embodiments, the dry composition comprises a diluent in an amount sufficient to reach 100wt% in combination with the other ingredients of the composition.

[0031] In many embodiments, the dry composition comprises ingredients that serve more than one purpose. In some embodiments, the dry composition comprises ingredients that serve as both a binder and a diluent. In some embodiments, the dry composition comprises ingredients that serve as both a flow aid or anti-caking agent and a diluent.

[0032] In many embodiments, the dry composition comprises no more than 2.5 wt% water. In some embodiments, the dry composition is substantially free of water. In some embodiments, the dry composition is free of water.

[0033] In many embodiments, the particle size of the dry composition is a key feature for these compositions. In some embodiments, the dry composition comprises particles having a D90 in the range of about 5 μm to about 35 μm. In some embodiments, the dry composition comprises particles having a D90 in the range of about 10 μm to about 35 μm. In some embodiments, wherein the dry composition comprises particles having a D90 in the range of about 5 μm to about 20 μm. In some embodiments, wherein the dry composition comprises particles having a D90 in the range of about 10 μm to about 20 μm.

[0034] Generally, the dry composition can be in any suitable form known in the art.In some embodiments, the dry composition is in the form of a water dispersible granule (WG) formulation or a wettable powder (WP) formulation.

[0035] Generally, the dry composition can be prepared according to any suitable method known in the art. In some embodiments, the dry composition is prepared according to the following method, which includes: (i) forming a mixture, the mixture comprising: about 10 wt% to about 30 wt% of an active ingredient having a low melting point; about 0.5 wt% to about 1.5 wt% of a wetting agent; about 0 wt% to about 20 wt% of a binder; about 0.5 wt% to about 30 wt% of a flow aid or anti-caking agent; about 1.0 wt% to about 5.0 wt% of a dispersant; about 0 wt% to 2 wt% of a defoamer; and about 55 wt% to about 90 wt% of a diluent; (ii) grinding the mixture; (iii) optionally wetting the mixture with water; (iv) optionally kneading the mixture wetted with water; (v) optionally extruding the mixture wetted with water; and (vi) optionally drying the mixture. In these embodiments, when steps (i) and (ii) are performed, the method produces a wettable powder (WP) formulation. Also in these embodiments, when steps (i), (ii), (iii), (iv), (v) and (vi) are performed, the process produces a water dispersible granule (WG) formulation.

[0036] Generally, the mixture may be ground according to any suitable grinding method known in the art. In some embodiments, the method step of grinding the mixture is performed in an apparatus designed to reduce the particle size of powders or dry materials.

[0037] In some embodiments, the method step of grinding the mixture comprises grinding the mixture to a particle size having a D90 in a range of about 5 μm to about 35 μm. In some embodiments, the method step of grinding the mixture comprises grinding the mixture to a particle size having a D90 in a range of about 10 μm to about 20 μm.

[0038] In some embodiments, the resulting dry composition method is substantially free of water. In some embodiments, the resulting dry composition method is free of water.

[0039] Generally, the dry composition can be used according to any suitable method known in the art. In some embodiments, the method of using the dry composition includes using the dry composition to control pests.

[0040] In certain embodiments, the method using dry composition comprises wetting this dry composition and using this wetted dry composition to prevent and treat harmful organisms.In certain embodiments, dry composition is added to a sink or reservoir and dispersed.Then dispersed composition is applied according to instructions to prevent and treat harmful organisms.In certain embodiments, dry composition is combined and mixed with other wet or dry harmful organism control compositions in the same sink or reservoir.Then the mixture of harmful organism control agent is applied according to instructions to prevent and treat harmful organisms.In certain embodiments, dry composition is packaged with other dry harmful organism control compositions, then they are combined and mixed with other wet or dry harmful organism control compositions in the same sink or reservoir.

[0041] Generally, the dry composition can be used to control any suitable pest known in the art.In some embodiments, the pest is selected from agronomic pests, non-agronomic pests, vertebrate pests, invertebrate pests, insects, and combinations thereof.

[0042] In some embodiments, the dry composition to be used is substantially free of water. In some embodiments, the dry composition to be used is free of water.

[0043] In some embodiments, the dry formulation further comprises an additional active ingredient selected from the group consisting of abamectin, acephate, acetamiprid, acralathrin, acynonapyr, sulfamethoxam ([(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-[(cyclopropylcarbonyl)oxy]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(3-pyridyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methylcyclopropanecarboxylate), sulfamethoxam , amitraz, avermectin, azadirachtin, azinphos-phos, benfuracarb, chlorpyrifos, benzpyrimoxan, bifenthrin, kappa-bifenthrin, bifenazate, bistrifluan, borate, broflanilide, buprofezin, cadusafos, carbaryl, carbofuran, cartap, chlorfenapyr, chlorfenapyr, chlorpyrifos-e, chlorpyrifos-methyl, chlorfenapyr, clofenazine, chloroprallethrin, thiamethoxam Amine, cyantraniliprole (3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1H-pyrazole-5-carboxamide), cyclobromothranil (3-bromo-N-[2-bromo-4-chloro-6-[[(1-cyclopropylethyl)amino]carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide), cypermethrin, cyclohexidine ((5S,8R)-1-[(6-chloro-3-pyridinyl)methyl]-2,3,5,6,7,8-hexahydro-9-nitro-5,8-epoxy-1H-imidazo[1,2-a]azepine), cypermethrin, cyfluthrin, cyfluthrin, high cypermethrin, cyhalothrin, cyhalothrin, cypermethrin, cis-cypermethrin, ζ-cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, dicloromestolide, dieldrin, diflubenzuron, tetrafluthrin, dimethoate, dimethoate, dimpropyridaz, dimethomorph, fenthiocarb, emamectin, emamectin benzoate, endosulfan, cypermethrin, ethoprolin, ether cypermethrin, ε-methofluthrin, etoxazole, fenbutatin, fenitrothion, fenthiocarb, fenoxycarb, cypermethrin, cypermethrin, fipronil, flumetoquinone (2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]-4-quinolylmethyl carbonate), flonicamid, triflumizone, flubendiamide, flucythrinate, flufenoxuron, flutolan ((αE)-2-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-α-(methoxymethylene)phenylacetic acid methyl ester), diflunisal (5-chloro-2-[(3,4,4-trifluoro-3-butene-1-yl)sulfonyl]thiazole), fluhexen, fluopyram, flupiperidone (1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methyl-2-propen-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile), flupyronil ( 4-[[(6-chloro-3-pyridyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone), flubilin, fluvalinate, fluvalinate, fluoxathrin, fluoxazolidinone, fluoxathrin, fluoxathrin amide, flufenoxim, flumethrin, thiophanate-methyl, chlorfenapyr, tefluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-[(1Z)-3,3,3-trifluoro-1-propene-1-yl]cyclopropanecarboxylate), hexaflumuron, hexathiazox, hydrazone, imidacloprid, indoxacarb, insecticidal soap, isopropylamine, isoxathiazole, κ-tefluthrin, cyhalothrin, cyfluthrin, fenthiocarb, malathion, tefluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-[(1Z)-3,3,3-trifluoro-1-propene-1-yl]cyclopropanecarboxylate), hexaflumuron, hexathiazox, hydrazone, imidacloprid, indoxacarb, insecticidal soap, isopropylamine, isoxathiazole, κ-tefluthrin, cyhalothrin, fenthiocarb, malathion, tefluthrin ([2,3,5,6-tetrafluoro-4- (Methoxymethyl) phenyl] methyl (1R, 3S) -3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate), metaflumizone, metaldehyde, methamidophos, methidathion, methiocarb, methomyl, methoprene, methoxychlor, metofluthrin, methoxyfenozide, ε-metofluthrin, ε-cyfluthrin, monocrotophos, monofluthrin ([2,3,5,6-tetrafluoro-4- (methoxymethyl) phenyl] methyl 3- (2-cyano-1-propen-1-yl) -2,2-dimethylcyclopropanecarboxylate), nicotine, nitenpyram, nithiazine, fluazifop, polyflumuron, N- [1,1-dimethyl-2- (methylthio) ethyl] -7-fluoro-2- (3-pyridyl) -2H-indazole-4-carboxylate amide, N-[1,1-dimethyl-2-(methylsulfinyl)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-(1-methylcyclopropyl)-2-(3-pyridyl)-2H-indazole-4-carboxamide, and N-[1-(difluoromethyl)cyclopropyl]-2-(3-pyridyl)-2H-indazole-4-carboxamide, oxamyl, benzothion, parathion, methyl parathion, permethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, profluthrin, propargyl, profenthrin, pyrimethrin, flubutamide (1,3,5-trimethyl-N-(2-methyl-1-oxypropyl)-N-[3-(2-methylpropyl)-4-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]phenyl]-1H-pyrazole-4-carboxamide), pymetrozine, pyraclostrobin, pyrethroids, pyraclostrobin, pyridabenzyl, pyridamidopropynil, pyrimethamine, pyridamole, pyrimidine, pyrimidine, pyrimidine, pyrimidine, pyrimidine, pyrimidine [trifluoromethyl]-4-pyrimidinyl]oxy]methyl]-α-(methoxymethylene)phenylacetic acid methyl ester), fluopicolide, pyraclostrobin, pyriproxyfen, rotenone, ryanodine, flutosan, ethyl spinosad, spinosad, spirodiclofen, spiromesifen, ethyl methoxypiperidin, spirotetramat, sulfoxaflor (N-[methyl oxide [1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfuron [alkyl] cyanamide), fenpyrad, tebufenamide, flubenzuron, tefluthrin, κ-tefluthrin, terbuthion, tetrachlorvinphos, cypermethrin, tetrafluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2,3,3-tetramethylcyclopropanecarboxylate), tetrazolyl cypermethrin, thiacloprid, thiamethoxam, thiodicarb, dimethoate, thiazoxafin (3-phenyl-5-(2-thienyl)-1 ,2,4-oxadiazole), tolfenpyrad, tralomethrin, triazomethan, trichlorfon, triflubenzuron (2,4-dioxo-1-(5-pyrimidinylmethyl)-3-[3-(trifluoromethyl)phenyl]-2H-pyrido[1,2-a]pyrimidinium salt), triflumuron, cypermethrin, highly effective cypermethrin, Bacillus thuringiensis delta-endotoxin, insect pathogenic bacteria, insect pathogenic viruses, insect pathogenic fungi, and combinations thereof. ,

[0044] The compositions of the present disclosure may optionally include one or more pest control agents selected from insecticides, herbicides, biopesticides, nematicides, bactericides and fungicides. General references for these pest control agents (i.e., insecticides, fungicides, nematicides, miticides, herbicides and biological agents) include The Pesticide Manual, 13th edition, edited by CDS Tomlin, British Crop Protection Council, Farnham, Surrey, UK, 2003 and The Bio Pesticide Manual, 2nd edition, edited by LG Copping, British Crop Protection Council, Farnham, Surrey, UK, 2001.

[0045] Non-limiting examples of insecticides include abamectin, acephate, acetamiprid, acralathrin, aknapyr, cypermethrin ([(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-[(cyclopropylcarbonyl)oxy]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(3-pyridyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methylcyclopropanecarboxylate), sulfamethoxam, amitraz, avermectin, azadirachtin, azoxystrobin, benfuracarb, Insecticidal sulfone, benzpyrimoxan, bifenthrin, kappa-bifenthrin, bifenazate, bistrifluan, borate, broflanilide, buprofezin, cadusafos, carbaryl, carbofuran, cartap, fenamiform, chlorfenapyr, chlorfluazuron, chloroprallethrin, chlorpyrifos, chlorpyrifos-e, methyl chlorpyrifos, chlorfenapyr, chlorfenapyr, clofenazine, chloroprallethrin, clothianidin, cypermethrin, cyclohexidine ((5S,8R)-1-[(6-chloro-3 -pyridyl)methyl]-2,3,5,6,7,8-hexahydro-9-nitro-5,8-epoxy-1H-imidazo[1,2-a]azepine), cypermethrin, cyfluthrin, cypermethrin, beta-cypermethrin, cypermethrin, cypermethrin, cypermethrin, zeta-cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, dicloromesotiaz, dieldrin, diflubenzuron, tetrafluthrin, dimethoate, methamidophos, dimethoate, fenthrin, dimethoate, emamectin, emamectin benzoate, endosulfan, cypermethrin, ethomethin, ε-methoxythrin Oxyfluthrin, etoxazole, fenbutatin, fenitrothion, fenthiocarb, fenoxycarb, cypermethrin, cypermethrin, fipronil, flumetolquinone (2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]-4-quinolylmethyl carbonate), flonicamid, triflumizone, flucythrinate, flufenoxuron, flutolan ((αE)-2-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-α-(methoxymethylene)phenylacetic acid methyl ester), diflunisal (5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]thiazole), fluhexenic acid, fluopyram, flupiprole (1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methyl-2-propen-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile), flupyrone (4-[[(6-chloro-3-pyridyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone), flupyrimin, fluvalinate, fluvalinate, fluoxathiol, fluoxazolidinone, flufenoxam, flufenoxam, flufenoxam, thiophanate-methyl, cyhalothrin, chlorfenapyr, tebuconazole ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-[(1Z)-3,3,3-trifluoro-1-propen-1-yl]cyclopropane esters), hexaflumuron, hexathiazolin, hydrazone, imidacloprid, indoxacarb, insecticidal soap, isopropylamine, isoxathiapiprolin, κ-tefluthrin, high-efficiency cyhalothrin, lufenuron, malathion, cyfluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate), metaflumizone, metaldehyde, methamidophos, methidathion, methiocarb, methomyl, methoprene, methoxychlor, methoxyfluthrin, methoxyfenozide, ε-methofluthrin, ε-cyfluthrin (momfluorothrin), monocrotophos, monofluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2-(2-cyano-1-propen-1-yl)-2,2-dimethylcyclopropanecarboxylate), nicotine, nitenpyram, nithiazine, fluazifop, polyflumuron, N-[1,1-dimethyl-2-(methylthio)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-[1,1-dimethyl-2-(methylsulfinyl)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-[1,1-dimethyl-2-(methylsulfinyl)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-7-fluoro-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-(1-methylcyclopropyl)-2-(3-pyridyl)-2H-indazole-4-carboxamide, N-[1-(dimethyl) [(1,3,5-trimethyl-N-(2-methyl-1-oxypropyl)-N-[3-(2-methylpropyl)-4-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]phenyl]-1H-pyrazole-4-carboxamide), pymetrozine, pyraclostrobin, pyrethrin ...4-dichlorophenyl)amino]-6-(trifluoromethyl)-4-pyrimidinyl]oxy]methyl]-α-(methoxymethylene)phenylacetic acid methyl ester), pyraclostrobin, pyriproxyfen, rotenone, ryanodine, flutosan, ethyl spinetoram, spinosad, spirodiclofen, spiromesifen, spiropidion, spirotetramat, sulfoxaflor (N-[methyl oxide [1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ, 4 -sulfuryl] cyanamide), tebufenozide, tebufenpyrad, flubenzuron, tefluthrin, κ-tefluthrin, terbufophos, cypermethrin, tetrathrin, tetrafluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2,3,3-tetramethylcyclopropanecarboxylate), thiacloprid, thiamethoxam, thiodicarb, dimethoate, thiazoxan (3-phenyl-5-(2-thienyl)-1,2,4-oxadiazole), tofenac amine, tralomethrin, triazomethin, trichlorfon, triflubenzuron (2,4-dioxo-1-(5-pyrimidinylmethyl)-3-[3-(trifluoromethyl)phenyl]-2H-pyrido[1,2-a]pyrimidinium inner salt), triflumuron, tyclopyrazoflor, highly effective cypermethrin, Bacillus thuringiensis delta-endotoxin, insect pathogenic bacteria, insect pathogenic viruses or insect pathogenic fungi, and combinations thereof.

[0046] Non-limiting examples of fungicides include fungicides such as benzothiadiazole, dimethylmorpholine, azoxystrobin, aminopyrifen, indazolsulfuron, captopril, azaconazole, azoxystrobin, benalaxyl (including benalaxyl-M), oxadone, benomyl, benthiavalicarb (including benthiavalicarb-isopropyl), benzovindiazole, bethoxazin, binapacryl, biphenyl, bifenthrin, bifenthrin, blasticidin-S, boscalid, oxadone, bupirimate, thiopyralid, carboxin, cyclopropane , captamipan, captan, carbendazim, chloroneb, thiophanate, chlozolinate, copper hydroxide, cupric oxychloride, copper sulfate, syringostyrin, cyazofamid, cyfluanid, cymoxanil, cyproconazole, cyprodinil, dichlobentiazox, diclofenac, diclocymet, diclomezine, dicloran, diethofencarb, difenoconazole, diflumetorim, dimethirimol, dimethomorph, dimethomorph, diniconazole, including diniconazole M)), diclofenac, dipymetitrone, dithianon, dithiocarb, dodecacyclic morpholine, docodine, econazole, ethoconazole, kefansan, enoxastrobin,Also known as enestroburin), epoxiconazole, ethaboxam, ethirimol, etridiazole, famoxadone, fenamidone, enoxaquinone, chlorfenapyr, fenbuconazole, furamide, fenhexamide, fenoxanil, fenpicoxamid, fenpropidine, fenpropimorph, fenpyraclostrobin, triphenyltin acetate, triphenyltin hydroxide, ferbam , ferimzone, flutoquinone, florylpicoxamid, fluoxadiazole, fluazinam, fludioxonil, flutolanil, fluindapyr, flumorph, fluopicolide, fluopicolide, fluoxapiprolin, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, fluthiazolin, flutolanil, flutriafol, fluopicolide, folpet, fthalide,Also known as phthalide), furaxyl, furaxyl, furazone, hexaconazole, hymexazole, guazatine, imazalil, iminoctadine albesilate, iminoctadine triacetate, inpyrfluxam, thiodicarb, ipconazole, ipfentrifluconazole, ipflufenoquin, isoprobenfos, isoprobenfos, propiconazole, isoflurane, isoflurane, isoflurane, isoflurane, kasugamycin, kresoxim-methyl, lancotrione, mancozeb, mandipropanil ndipropamid), mandestrobin, maneb, mapanipyrin, clofothiazide, mefenoxam, meptyldinocap, metalaxyl (including metalaxyl-M / mefenoxam), metconazole, methasulfocarb, metiram, mefenoxam, metyltetraprole, mefentrazone, myclobutanil, naftitine, ferric ammonium arsenate (ferric arsenate), methanearsonate), flufenamic acid, oxathiapiprolin, furamide, orysastrobin, oxadixyl, oxathiapiprolin, oxolinic acid, oxpoconazole, oxycarboxin, oxytetracycline, penconazole, pencycuron, fluopicolide, penthiopyrad, perfurazoate, phosphorous acid (including salts thereof, for example, fosetyl-aluminum), picoxystrobin, piperalin, polyoxin, thiabendazole, prochloraz, procymidone, propamocarb, propiconazole, propineb, proquinazid, prothiocarb, prothioconazole, fluopicolide, Pyraclostrobin, pyraclostrobin, pyrapropoyne, pyraclostrobin, pyraziflumid, pyraclofos, pyraclofos, pyributacarb, pyridachlometyl, pyrifenox, pyriofenone, perisoxazole, pyrimethanil, pyrrolnitrin, pyroquilon, fluquinazole, quinmethionate , quinofumelin, quinoxyfen, pentachloronitrobenzene, silthiofam, sedaxane, simeconazole, spiroxafil, streptomycin, sulfur, tebuconazole, isobutylethoxyquin, teclofthalam, teclofthalam, tetrachloronitrobenzene, terbinafine, fluconazole, thiabendazole, thiofuranamide, thiophanate, methyl thiophanate, serene, thiocarbamide, methyl tolprocarb, tolfluanid, triadimefon, triadimenol, myclobutanil, triazoxide, basic copper sulfate (tribasic copper sulfate), chlorpyrifos-butyl, tridemorph, trifloxystrobin, triflumizole, trimoprhamide tricyclazole, trifloxystrobin, triamcin, trichlorfonazole, uniconazole, validamycin, valifenalate (also known as valifenal), vinclozoline, mancozeb, ziram, zoxamide, 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, and combinations thereof.

[0047] Non-limiting examples of nematicides include fluopyram, spirotetramat, thiodicarb, thiothiazolyl, abatin, iprodione, diflunisal, dimethyl disulfide, thiothiazolyl, 1,3-dichloropropylene (1,3-D), metamidine (sodium and potassium), dazomet, chloropicrin, fenamiphos, ethanophos, cadusaphos, terbuthion, imicyafos, oxamyl, carbofuran, thiothiazolyl, Bacillus firmus, Pasteuria nishizawae, and combinations thereof. Non-limiting examples of bactericides are streptomycin. Non-limiting examples of miticides include amitraz, chlorpyrifos, chlorfenapyr, cyhexatin, dicofol, cyfluthrin, etoxazole, fenazaquin, fenbutatin, cypermethrin, fenpyroxithrin, hexythiazox, propargyl, pyridaben, tebufenpyrad, and combinations thereof.

[0048] Herbivorous insects

[0049] Herbivorous insects are invertebrate pests that damage plants by feeding, such as by eating foliage, stems, leaves, fruit, or seed tissue or by sucking the plant's vascular fluid. Leaf feeders can be external (exophytic) or they can mine tissue, sometimes even specifically targeting specific cell types. Herbivorous insect species exist in most insect orders, including Hemiptera, Thysanoptera, Orthoptera, Lepidoptera, Coleoptera, Heteroptera, Hymenoptera, and Diptera.

[0050] Examples of agronomic or non-agronomic invertebrate pests include eggs, larvae and adults of the order Lepidoptera, such as armyworms, cutworms, loopers and heliothines of the family Noctuidae (e.g., Sesamia inferens Walker, Sesamia nonagrioides Lefebvre, Spodoptera eridania Cramer, Spodoptera frugiperda J.E. Smith, Spodoptera exigua Hübner, Spodoptera littoralis Boisduval, Spodoptera ornithogalli Guenée, Agrotis ipsilon Hufnagel, Anticarsia gemmatalis Hübner, Lithophane antennata Walker, Barathra brassicae Linnaeus, Pseudoplusia includens Walker, Trichoplusia ni Hübner, Heliothis virescens Fabricius); borers, casebearers, webworms, coneworms, cabbageworms and skeletonizers from the family Pyralidae (e.g., European corn borer (Ostrinia nubilalis Hübner), navel orange borer (Amyelois transitella Walker), corn root webworm (Crambus caliginosellus Clemens), sod borer (Crambus caliginosellus Clemens), webworms (Crambinae: Crambinae),Such as sod worm (Herpetogrammalicarsisalis Walker), sugarcane stem borer (Chiloinfuscatellus Snellen), tomato small borer (Neoleucinodeselegantalis Guenée), green leaf roller (Cnaphalocrocismedinalis), grape leaf folder (Desmia funeralis Hübner), melon worm (Diaphania nitidalis Stoll), cabbage center grub (Helluala hydralis Guenée), yellow stem borer (Scirpophaga incertulas Walker), early shoot borer (Scirpophaga infuscatellus Snellen), white stem borer (Scirpophaga innotata Walker), top shoot borer (Scirpophaga nivella Fabricius), dark-headed rice borer (Chilo polychrysus Meyrick), striped rice borer (Chilo suppressalis Walker), cabbage cluster caterpillar (Crocidolomia binotalis English); leaf rollers, budworms, seed worms and fruit worms of the family Tortricidae (e.g., codling moth, Cydia pomonella Linnaeus), grape berry moth (Endopiza viteana Clemens), oriental fruit moth,Grapholita molesta Busck), citrus false codling moth (Cryptophlebia leucotreta Meyrick), citrus borer (Ecdytolophaaurantiana Lima), redbanded leafroller (Argyrotaenia velutinana Walker), obliquebanded leafroller (Choristoneura rosaceana Harris), light brown apple moth (Eupoecilia ambiguella Hübner), apple bud moth (Pandemis pyrusana Kearfott), omnivorous leafroller (Platynota stultana Walsingham), barred fruit-tree tortrix (Pandemis cerasana Hübner), applebrown tortrix (Pandemis heparana Denis & Schiffermüller); and many other economically important Lepidoptera (e.g.diamondback moth (Plutella xylostella Linnaeus), pink bollworm (Pectinophoragossypiella Saunders), gypsy moth (Lymantria dispar Linnaeus), peach borer (Carposinaniponensis Walsingham), peach moth (Anarsia lineatella Zeller), potato tuber moth (Phthorimaea operculella Zeller), (Lithocolletis blancardella Fabricius), apple moth (Lithocolletis ringoniella Matsumura), rice leaf folder (Lerodea eufala Edwards), spiral leaf miner (Leucoptera scitella Zeller); eggs, nymphs and adults of the order Blattellidae, including cockroaches from the families Blattellidae and Blattaria (e.g.,Oriental cockroach (Blatta orientalis Linnaeus), Asian cockroach (Blatella asahinai Mizukubo), German cockroach (Blattella germanica Linnaeus), brownbanded cockroach (Supella longipalpa Fabricius), American cockroach (Periplaneta americana Linnaeus), brown cockroach (Periplaneta brunnea Burmeister), Madeira cockroach (Leucophaea maderae Fabricius), smoky brown cockroach (Periplaneta fuliginosa Service), Australian cockroach ( cockroach (Periplaneta australasiae Fabr.), lobster cockroach (Nauphoeta cinerea Olivier), and smooth cockroach (Symplocepallens Stephens); eggs, leaf-feeding, fruit-feeding, root-feeding, seed-feeding, and vesicular tissue-feeding larvae and adults of the order Coleoptera, including weevils from the families Anthribidae, Bruchidae, and Curculionidae (e.g., boll weevil (Anthonomus grandis Boheman), rice water weevil (Lissorhoptrusoryzophilus Kuschel), granary weevil (Sitophilus granarius Linnaeus), rice weevil (Rice weevil weevil,oryzae Linnaeus), annual bluegrassweevil (Listronotus maculicollis Dietz), bluegrass billbug (Sphenophorus parvulus Gyllenhal), hunting billbug (Sphenophorus venatus vestitus), Denver billbug (Sphenophorus cicatristriatus Fahraeus); flea beetles, cucumber beetles, rootworms, leaf beetles, potato beetles, and leaf miners (e.g., Colorado potato beetle (Leptinotarsa ​​decemlineata) of the family Chrysomelidae. Say), western cornrootworm (Diabrotica virgifera LeConte); scarab beetles and other beetles from the family Scarabaeidae (e.g., Japanese beetle (Popilliajaponica Newman), oriental beetle (Popilliajaponica Newman),Anomala orientalis Waterhouse, Exomala orientalis (Waterhouse) Baraud), northern masked chafer (Cyclocephala borealis Arrow), southern masked chafer (Cyclocephala immaculata Olivier or C. lurida Bland), dung beetle and white grub (Aphodius species), black turfgrass ataenius (Ataenius spretulus Haldeman), green June beetle (Cotinis nitida Linnaeus), Asiatic garden beetle (Maladera castanea Arrow), May / June beetles (Phyllophaga juncea species) and European chafer (Rhizotrogus majalis Razoumowsky); carpet beetles from the family Dermestidae; wireworms from the family Elateridae; bark beetles from the family Scolytidae and flourbeetles from the family Tenebrionidae.

[0051] In addition, agronomic and non-agronomic pests include: eggs, adults and larvae of the order Dermoptera, including earwigs from the family Forficulidae (e.g., European earwig (Forficulaauricularia Linnaeus), black earwig (Chelisoches morio Fabricius));Eggs, larvae, adults and nymphs of the orders Hemiptera and Homoptera, such as plant bugs from the family Miridae, cicadas from the family Cicadidae, leafhoppers from the family Cicadellidae (e.g., Empoasca species), potato leafhoppers, bed bugs from the family Cimicidae (e.g., Cimex lectularius Linnaeus), planthoppers from the families Fulgoroidae and Delphacidae, treehoppers from the family Membracidae, psyllids from the family Psyllidae, whiteflies from the family Aleyrodidae, aphids from the family Aphididae, phylloxera from the family Phylloxeridae, mealybugs from the family Pseudococcidae, scales from the families Coccidae, Diaspididae, and Margarodidae, lace bugs from the family Tingidae, stink bugs from the family Pentatomidae, bugs), chinchbugs from the Lygaeidae family (e.g., hairy chinch bugs (Blissus leucopterus hirtus Montandon) and southern chinch bugs (Blissus insularis Barber)), and other seed bugs from the Lygaeidae family, spittlebugs from the Cercopidae family, squash bugs from the Coreidae family, and red bugs and cotton stainers from the Coreidae family. ;

[0052] Agronomic and non-agronomic pests also include: eggs, larvae, nymphs and adults of the order Acari (mites), such as spider mites and red mites of the family Tetranychidae (e.g., Panonychus ulmi Koch, Tetranychus urticae Koch, Tetranychusmcdanieli McGregor); flat mites of the family Tenuipalpidae (e.g., citrus flat mite (Brevipalpus lewisi McGregor)); rust mites and bud mites of the family Eriophyidae. mite, as well as other leaf-feeding mites and mites of importance in human and animal health, namely, dust mites of the family Epidermoptidae, hair follicle mites of the family Demodicidae, grain mites of the family Glycyphagidae; ticks of the family Ixodidae, commonly known as hard ticks (e.g., deer tick (Ixodes scapularis Say), Australian paralysis tick (Ixodes holocyclus Neumann), American dog tick (Dermacentor variabilis Say), lone star tick (Amblyomma americanum Linnaeus)) and ticks of the family Argasidae, commonly known as soft ticks (e.g., relapsing fever tick (Ornithodoros turicata), common fowl tick (Argas radiatus); scab mites and itch mites of the families Psoroptidae, Pyemotidae, and Sarcoptidae; eggs, adults, and larvae of Orthoptera, including grasshoppers, locusts, and crickets (e.g., migratory grasshoppers (e.g., Melanoplus sanguinipes Fabricius), M.differentialis Thomas), American grasshoppers (e.g., American desert locust (Schistocerca americana Drury), desert locust (Schistocerca gregaria Forskal), migratory locust (Locustamigratoria Linnaeus), bush locust (Zonocerus species), house cricket (Acheta domesticus Linnaeus), mole crickets (e.g., tawny mole cricket (Scapteriscus vicinus Scudder) and southern mole cricket (Scapteriscus borellii Giglio-Tos)); eggs, adults and larvae of Diptera, including leaf miners (e.g., Liriomyza species, such as serpentine vegetable leafminer (Lyriomyza spp.), and larvae of Diptera. leafminer (Liriomyza sativae Blanchard), midges, fruit flies (Tephritidae), frit flies (e.g., Oscinella frit Linnaeus), soil maggots, house flies (e.g., Musca domestica Linnaeus), lesser house flies (e.g., Fannia canicularis Linnaeus), lesser house flies (e.g., F.femoralis Stein), stable flies (e.g., Stomoxys calcitrans Linnaeus), face flies, horn flies, blow flies (e.g., Chrysomya species, Phormia species) and other muscoid fly pests, horse flies (e.g., Tabanus species), bot flies (e.g., Gastrophilus species, Oestrus species), cattle grubs (e.g., Hypoderma species), deer flies (e.g., Chrysops species), keds (e.g., Melophagus ovinus Linnaeus) and other Brachycera, mosquitoes (e.g., Aedes species, Anopheles species, Culex species), black flies (e.g., Prosimulium species, Simulium species), biting midges, sand flies, sciarids, and other Nematocera; eggs, adults, and larvae of Thysanoptera, including onion thrips.

[0053] (Thrips tabaci Lindeman), flower thrips (Thrips spp.

[0054] (Frankliniella species) and other leaf-feeding thrips; insect pests of the order Hymenoptera, including ants of the family Formicidae, including Florida carpenter ants (Camponotus floridanus Buckley), red carpenter ants (Camponotusferrugineus Fabricius), black carpenter ants (Camponotus pennsylvanicusDe Geer), white-footed ants (Technomyrmex albipes fr. Smith), bigheaded ants (Pheidole species), ghost ants (Tapinomamelanocephalum Fabricius); Pharaoh ants (Monomorium pharaonisLinnaeus), little fire ants (Wasmannia auropunctata Roger), fire ant (Solenopsis geminata Fabricius), red imported fire ant (Solenopsis invicta Buren), Argentine ant (Iridomyrmex humilis Mayr), crazy ant (Paratrechina longicornis Latreille), pavement ant

[0055] (Tetramorium caespitum Linnaeus), cornfield ant (Lasius alienus ) and odorous house ants (Tapinoma sessileSay). Other Hymenoptera, including bees (including carpenter bees), hornets, yellow jackets, wasps, and sawflies (Neodiprion species; Cephus species); insect pests of the order Isoptera, including the family Termitidae

[0056] The termites include the family of termites (e.g., Macrotermes species, Odontotermes obesus Rambur), the family of Kalotermitidae (e.g., Cryptotermes species), and the family of Rhinotermitidae (e.g., Reticulitermes species, Coptotermes

[0057] (Coptotermes) species, Heterotermes tenuis Hagen), Eastern subterranean termites (Reticulitermes flavipes Kollar), Western subterranean termites (Reticulitermes hesperusBank), House termites, West Indian drywood termites (Incisitermesimmigrans Snyder), Cryptotermesbrevis Walker, Drywood termites (Incisitermes snyderi Light), Southeastern subterranean termites

[0058] (Reticulitermes virginicus Banks), western drywood termites (Incisitermes minor Hagen), arboreal termites such as species of the genus Nasutitermes, and other termites of economic importance; insect pests of the order Thysanura, such as silverfish (Lepismasaccharina Linnaeus) and firebrat (Thermobia domestica Packard); insect pests of the order Trichophagus, including head louse (Pediculus humanus capitis De Geer), body louse (Pediculus humanus Linnaeus), chicken body louse (Menacanthus stramineus Nitszch), dog biting louse (Trichodectes canis De Geer), fluff louse (Goniocotes gallinae De Geer), sheep body louse (Euphorbia edulis), and scurvy louse. louse) (Bovicolaovis Schrank), short-nosed cattle louse (Haematopinus eurysternus Nitzsch), long-nosed cattle louse (Linognathus vituli Linnaeus), and other sucking and chewing parasitic lice that attack humans and animals;Insect pests of the order Siphonoptera, including theoriental rat flea (Xenopsylla cheopis Rothschild), cat flea (Ctenocephalides felis Bouche), dog flea (Ctenocephalides canis Curtis), hen flea (Ceratophyllus gallinae Schrank), sticktight flea (Echidnophaga gallinacea Westwood), human flea (Pulex irritans Linnaeus), and other fleas that afflict mammals and birds. Additional arthropod pests covered include spiders of the order Araneae, such as the brown recluse spider (Loxosceles reclusa Gertsch & Mulaik) and the black widow spider (Latrodectus mactans Fabricius), and centipedes of the order Scolopendra, such as the house centipede (Scutigera coleoptrata Linnaeus).

[0059] Examples of invertebrate pests in stored grain include larger grain borer (Prostephanus truncatus), lesser grain borer (Rhyzopertha dominica), rice weevil (Stiophilus oryzae), maize weevil (Stiophilus zeamais), cowpea weevil (Callosobruchus maculatus), red flourbeetle (Tribolium castaneum), granary weevil (Stiophilus granarius), Indian meal moth (Plodia interpunctella), Mediterranean flourbeetle (Ephestia kuhniella), and flat or rusty grain beetle (Ephestia kuhniella). beetle)(Rusty red flat grain beetle (Cryptolestis ferrugineus)).

[0060] The compounds of the disclosure may have activity against members of the classes Nematoda, Cestoda, Trematoda, and Acanthocephala, including economically important members of the orders Strongylida, Ascaridida, Oxyurida, Rhabditida, Spirurida, and Enoplida, such as, but not limited to, economically important agricultural pests (i.e., root-knot nematodes in the genus Meloidogyne, lesion nematodes in the genus Pratylenchus, stubby root nematodes in the genus Trichodorus, etc.), as well as animal and human health pests (i.e., all economically important trematodes, tapeworms, and roundworms, such as Strongylus vulgaris in horses, etc.). vulgaris in dogs, Toxocara canis in dogs, Haemonchus contortus in sheep, Dirofilaria immitis Leidy in dogs, Anoplocephala perfoliata in horses, Fasciola hepatica Linnaeus in ruminants, etc.

[0061] The compositions of the present disclosure may have activity against pests in the order Lepidoptera (e.g., Alabama argillacea Hübner (cotton leafworm), Archips argyrospila Walker (fruit leaf roller), A.rosana Linnaeus (European leaf roller) and other species of Archips, Chilo suppressalis Walker (rice borer), Cnaphalocrosis medinalis Guenée (rice leaf roller), Crambus caliginosellus Clemens (corn root webworm), Crambus teterrellus Zincken (bluegrass webworm), Cydiapomonella Linnaeus (codling moth), Earias insulana Boisduval (spiny stem borer), Earias vittella Fabricius (spotted stem borer), Helicoverpaarmigera Hübner (American bollworm), Helicoverpa zea Boddie (corn earworm), Heliothis virescens Fabricius (tobacco budworm), Herpetogramma licarsisalis Walker (sod webworm), Lobesia botrana Denis & Schiffermüller (grape leafroller), Pectinophora gossypiella Saunders (pink bollworm), Phyllocnistis citrella Stainton (citrus leafminer), Pieris brassicae Linnaeus (large white cabbage butterfly), Pieris rapae Linnaeus (small white cabbage butterfly), Plutella xylostella Linnaeus (diamond back moth), Spodoptera exigua Hübner (beet armyworm), Spodoptera litura Fabricius (tobacco armyworm) cutworm, cluster caterpillar), Spodopterafrugiperda JESmith (fall armyworm), Trichoplusia ni Hübner (cabbage looper) and Tutaabsoluta Meyrick (tomato leafminer).

[0062] The compositions of the present disclosure can have significant activity against members from the order Homoptera, including: Acyrthosiphon pisum Harris, pea aphid, Aphis craccivora Koch (cowpea aphid), Aphis fabae Scopoli (black bean aphid), Aphis gossypii Glover (cotton aphid, melon aphid), Aphis pomi De Geer (apple aphid), Aphis spiraecola Patch (spirea aphid), Aulacorthum solani Kaltenbach (foxglove aphid), Chaetosiphon fragaefolii Cockerell (strawberry aphid), Diuraphis noxia (Diuraphis noxia) and Diuraphis spp. Kurdjumov / Mordvilko (Russian wheat aphid), Dysaphis plantaginea Paaserini (rosy apple aphid), Eriosoma lanigerum Hausmann (wooly apple aphid), Hyalopterus pruniGeoffroy (mealy plum aphid), Lipaphis erysimi Kaltenbach (turnip aphid), Metopolophium dirrhodum Walker (cereal aphid), Macrosiphum euphorbiae Thomas (potato aphid), Myzus persicae Sulzer (peach-potato aphid, green peach aphid), Nasonovia ribisnigri Mosley (lettuce aphid),lettuce aphid), Pemphigus species (root aphids and gallaphids), corn leaf aphid (Rhopalosiphum maidis Fitch), bird cherry-oat aphid (Rhopalosiphum padi Linnaeus), greenbug (Schizaphis graminum Rondani), English grain aphid (Sitobion avenae Fabricius), spotted alfalfa aphid (Therioaphis maculata Buckton), black citrus aphid (Toxoptera aurantii Boyer de Fonscolombe), and brown citrus aphid (Toxoptera citricida Kirkaldy). aphid; Adelges species (adelgids); Phylloxera devastatrix Pergande (pecanphylloxera); Bemisia tabaci Gennadius (tobacco whitefly, sweetpotato whitefly), Bemisia argentifolii Bellows & Perring (silverleaf whitefly), Dialeurodes citri Ashmead (citrus whitefly), and Trialeurodes vaporariorum Westwood (greenhouse whitefly; Empoasca fabae Harris (potato leafhopper), Laodelphax striatellus Fallen (smaller brown planthopper), Macrolestes quadrilineatus Forbes (aster leafhopper), Nephotettix cinticeps Uhler (green leafhopper), Nephotettix nigropictus, ) (rice leafhopper), brown planthopper (Nilaparvata lugens brown planthopper), Peregrinus maidis Ashmead (corn planthopper), Sogatellafurcifera Horvath (white-backed planthopper), Sogatodes orizicola Muir (rice delphacid), Typhlocyba pomaria McAtee (white appleleafhopper), Erythroneoura species (grape leafhoppers); Magicidada septendecim Linnaeus (periodical cicada); Icerya purchasi Maskell (cottony cushion scale), Quadraspidiotusperniciosus Comstock (San Jose scale); Planococcus citri Risso (citrus mealybug); mealybug); Pseudococcus species (other mealybug groups); pear psylla (Cacopsyllapyricola Foerster), persimmon psylla (Trioza diospyri Ashmead).

[0063] The compositions of the disclosure may also have activity against members from the order Hemiptera, including: Acrosternum hilare Say (green stink bug), Anasa tristis DeGeer (squash bug), Blissus leucopterus Say (chinchbug), Cimex lectularius Linnaeus (bedbug), Corythuca gossypiiFabricius (cotton lace bug), Cyrtopeltis modesta Distant (tomatobug), Dysdercus suturellus (blackwinged stink ... ) (cotton stainer), brown stink bug (Euchistus servus Say), one-spotted stink bug (Euchistus variolarius Palisot de Beauvois), Graptosthetus species (complex of seed bugs), Halymorpha halys )(brownmarmorated stink bug), Leptoglossus corculus Say, leaf-footed pineseed bug, Lygus lineolaris Palisot de Beauvois, tarnished plantbug, Nezara viridula Linnaeus (southern green stink bug), Oebalus pugnax Fabricius (rice stink bug), Oncopeltus fasciatus Dallas (large milkweed bug), Pseudatomoscelis seriatus Reuter, cotton fleahopper. Other insect orders controlled by the compounds of the present disclosure include Thysanoptera (e.g., Frankliniella occidentalis Pergande, westernflower thrips, Scirthothrips citri Moulton (citrus thrips), Sericothrips variabilis Beach, soybean thrips, and Thrips tabaci (onion thrips)); and Coleoptera (e.g., Colorado potato beetle, Mexican bean beetle, and wireworms of the genera Agriotes, Athous, or Limonius).

[0064] In some aspects, the compositions of the present disclosure can be used to control western flower thrips (Frankliniella occidentalis). In some aspects, the compositions of the present disclosure can be used to control potato leafhoppers (Empoasca fabae). In some aspects, the compositions of the present disclosure can be used to control cotton aphids (Aphis gossypii). In some aspects, the compositions of the present disclosure can be used to control diamondback moths (Plutella xylostella L.). In some aspects, the compositions of the present disclosure can be used to control silverleaf whiteflies (Bemisia argentifolii Bellows & Perring).

[0065] In terms of cyantraniliprole of the present disclosure, the compositions of the present disclosure are effective against the following: Coleoptera, Chrysomelidae, Cerotoma trifurcata bean leaf beetle, Chaetocnema concinna beet flea beetle, Epilax varivestis Mexican beetle, Epitrix cucumeris potato flea beetle, Leptinotarsa ​​decemlineata Colorado potato beetle, Oulema melanopus cereal leaf beetle, Oulemaoryzae rice leaf beetle, Phyllotreta cruciiferae cabbage flea beetle, Phyllotreta striolata striped flea beetle, Psylliodes spp. spp.flea beetles), Curculionidae, Anthonomuseugenii pepper weevil, Ceutorhynchus napi cabbage stem weevil, Ceutorhynchus quadridens cabbage seed-stalk curculio, Conotrachelus nenuphar plumcurculio, Hypera bruneipennis Egyptianalfalfa weevil, Hypera postica alfalfa weevil, Lissorhoptrus oryzophilus rice water weevil, Nitidulidae, Meligethes aeneus pollen beetle, blossom beetle, Scarabaeidae, Cotinis nitida green June beetlebeetle, Phyllophaga spp. June beetles, grubs, Popilliajaponica Japanese beetle, Diptera, Agromyzidae, Liromyza chinensis stone leek leafminer, Liromyza huidobrensis pea leafminer, Liriomyza sativae serpentine / vegetable leafminer, Liromyza trifolii American serpentine leafminer, Anthomyiidae, Delia antiqua onion fly, Delia platuraseedcorn maggot, Muscidae, Atherigona oryzae rice seedlingfly), Psilidae, Psila rosae carrot fly, Tephritidae, Anastrepha fraterculus South American fruit fly, Anastrepha ludens Mexican fruit fly, Anasterpha striata guavafruit fly, Bactrocera cucurbitae melon fly, Bactroceradorsalis oriental fruit fly, Bactrocera oleae olive fly, Ceratitis capitata Mediterranean fruit fly, Chromatomyiahorticola garden pea leafminer, Rhagoletis cerasi cherry fruitfly, Rhagoletis cingulata cherry fruitfly, Rhagoletisindifferens western cherry fruit fly), Rhagoletispomonella apple maggot, Hemiptera, Aleyrodidae, Aleyrodes proletella cabbage whitefly, Bemisia tabaci sweet potato whitefly, cotton whitefly, Dialeurodes citri citrus whitefly, Trialeurodes vaporariorum, greenhouse whitefly, Aphididae, Acyrthosiphon pisum pea aphid, Aphis craccivora cowpea aphid, Aphis fabae black bean aphid, Aphis glycines soybean aphid, Aphis gossypii cotton aphid, melonaphid, Aphis nasturtii buckthorn aphid, Aphis pomi greenapple aphid, Aphis spiraceola spirea aphid, Aulacorthumsolani foxglove aphid, Brachycaudus persicae black peach aphid, Brevicoryne brassicae cabbage aphid, Chromaphisjuglandicola European walnut aphid, Dysaphis plantaginea rosyapple aphid, Hyalopterus pruni mealy plum aphid, Lipaphiserysimi mustard aphid, turnip aphid, Macrosiphumeuphorbiae potato aphid, Myzuspersicae green peach aphid, peachpotato aphid, Rhopalosiphum padi bird cherry oat aphid, Rhopalosiphum nymphaeae plum aphid, Schizaphis graminumgreenbug, Sitobion avenae English grain aphid, Therioaphis maculata spotted alfalfa aphid, Toxoptera citricidabrown citrus aphid, oriental citrus aphid, Cicadellidae, Empoasca fabae leafhopper / jassid complex, Empoasca vitisgreen frogfly, Hortensia similis common green leafhopper leafhopper), Idioscopus spp.mango leafhopper, Jacobiascalybica cotton jassid, Nephotettix spp.rice greenleafhopper complex, Typhlocyba rosae rose leafhopper, Typhlocyba pomaria white apple leafhopper, Coreidae Leptocorisaoratorius rice bug, rice ear bug, paddy bug, Delphacidae, Nilaparvata lugens rice brown planthopper, Diaspididae, Aonidiella aurantii citrus scale, Flatidae, Metcalfa pruinosa citrus flatidplanthopper), Pentatomidae, Euschistus spp. brown stinkbugs, Edessa spp. stink bugs, Psyllidae, Diaphorina citri Asian citrus psyllid, Paratrioza cockerelli potato psyllid, tomato psyllid, Trioza eugeniae eugenia psyllid, lillypilly psyllid, Hymenoptera Tenthredinidae, Hoplocampa testudinea European apple sawfly, Lepidoptera, Crambidae, Scirpophaga incertulas yellow (rice) stemborer), Gelechiidae, Anarsia lineatella peach twig borer, Keiferia lycopersicella tomato pinworm, Pectinophora gossypiellapink bollworm, Tuta absoluta tomato leafminer, Gracilariariidae, Gracilaria theivora tea leafroller, Phyllonorycter blancardella spotted tentiform leafminer, Phyllonorycter coryfoliella nut leaf blister moth, Phyllonorycter crataegella apple blotch leafminer, Phyllonorycter ringoniella apple leafminer, Phyllonorycterelmaella western tentiform leafminerleafminer), Hesperiidae, Borbocinara rice leafroller, Lyonetiidae, Leucoptera coffeellawhite coffee leafminer, Leucoptera scitella pear leaf blistermoth, Lyonetia clerkella peach, leaf miner, Noctuidae, Agrotis segetum common cutworm, Alabamaargillacea cotton leafworn, Autographa californica alfalfalooper, Barathra brassicae cabbage armyworm, Chrysodeixis chalcites green garden looper, Chrysodeixis eriosomagreen semi-looper, Earias insulana Egyptian bollworm, Earias vittella northern rough bollworm, Feltia subterranea granulate cutworm, Helicoverpa armigera American bollworm, cotton bollworm, Helicoverpa punctigera climbing cutworm, Heliothis virescens tobacco budworm, Helicoverpa zea corn earworm, Prodenia ornithogalli yellow-striped armyworm, Pseudaletia unipuncta true armyworm, Pseudoplusia includens soybean looper, Sesamia inferenspink(rice)stemworm), Spodopteraeridania southern armyworm, Spodoptera exigua beet armyworm, Spodoptera frugiperda fall armyworm, Spodoptera littoraliscotton leafworm, Spodoptera litura cluster caterpillar, Thermesia gemmatalis velvetbean caterpillar, Trichoplusia nicabbage looper, Phyllocnistidae, Phyllocnistis citrellacitrus leafminer, Pieridae, Colias eurytheme alfalfacaterpillar, Leptophobia aripa green-eyed white, Pieris brassicaecabbage butterfly), large white, Pieris rapae imported cabbage worm, cabbage white, Plutellidae, Plutellaxylostella diamondback moth, Pyralidae, Chilo suppressalis Asiatic rice stemborer, Cnaphalocerus medinalis rice leaffolder, Crocidolomia binotalis cabbage caterpillar, Desmia funeralis grape leaffolder, Diaphania indica cotton caterpillar, Diaphania nitidaltis melonworm, Hellula hydralis cabbage center grub, Hellula undalis cabbagewebworm), Lerodea eufala rice leaffolder, Leucinodes orbonalis brinjal fruit borer, Maruca testulalis bean pod borer, Neoleucinodes elegantalis small tomato borer, Nymphula depunctalis rice caseworm, Ostrinia furnicalis Asiancorn borer, Ostrinia nubilalis European corn borer, Sphingidae, Manduca sexta tomato hornworm, tobacco hornworm, Smerinthus spp. sphinx moths, Tortricidae, Adoxophyes orana summer fruit borer tortrix), Argyrotaenia pulchellana grape tortrix, Argyrotaenia velutinana red-banded leafroller, Choristoneura rosaceana oblique-banded leafroller, Eupoecilia ambiguella grape berry moth, Cydia pomonella codling moth, Cydia prunivora lesser apple worm, Grapholita molesta oriental fruit moth, Lobesia botrana grape vine moth, Pandemis heparana apple brown tortrix, Pandemis limitata three-lined leaf roller, Paramyelois transitella navelorangeworm), Platynota idaeusalis tufted applebud moth, Platynota stultana omnivorus leafroller, Thysanoptera, Thripidae, Enneothrips flavens, Frankliniellafusca tobacco thrips, Frankliniella intonsa European flowerthrips, Frankliniella occidentalis western flower thrips, Frankliniella schultzei common blossom thrips, Frankliniellatritici eastern flower thrips, Megalurothrips sjostedti cowpeathrips, Megalurothrips usitatus bean blossom thrips, Scirthothrips citri citrus thrips), Scirthothrips dorsalis yellowtea thrips, chilli thrips, Sericothrips variabilis soybeanthrips, Stenchaetothrips biformis oriental rice thrips, Thrips arizonensis cotton thrips, Thrips meridionalis peach thrips, Thrips palmi melon thrips and Thrips tabaci onion thrips, common cotton thrips.

[0066] In some cyantraniliprole aspects of the present disclosure, the compositions of the present disclosure are effective against: Leptinotarsa ​​decemlineata Colorado potato beetle, Oulema oryzae leaf beetle, Phyllotreta cruciiferae cabbage flea beetle, Phyllotreta striolata striped flea beetle, Psylliodes spp. flea beetles, Anthonomus eugenii pepper weevil, Conotrachelus nenuphar plum curculio, Lissorhoptrus oryzophilus rice water weevil, Meligethes aeneus pollen beetle, blossom beetle, Liromyza chinensis stone leek leafminer), Liromyza huidobrensis pea leafminer, Liriomyza sativaeserpentine / vegetable leafminer, Liromyza trifolii Americanserpentine leafminer, Delia antiqua onion fly, Deliaplatura seedcorn maggot, Psila rosae carrot fly, Bactrocera dorsalis oriental fruit fly, Bactrocera oleae olivefly, Ceratitis capitata Mediterranean fruit fly, Rhagoletis indifferens western cherry fruit fly, Rhagoletispomonella apple maggot, Bemisia tabaci sweet potato whiteflywhitefly, cotton whitefly, Trialeurodes vaporariorum, greenhouse whitefly, Acyrthosiphon pisum pea aphid, Aphis craccivoracowpea aphid, Aphis fabae black bean aphid, Aphis gossypii cottonaphid, melon aphid, Aphis pomi green apple aphid, Aphis spiraceola spirea aphid, Aulacorthum solani foxglove aphid, Brevicoryne brassicae cabbage aphid, Dysaphis plantaginearosy apple aphid, Lipaphis erysimi mustard aphid aphid, turnip aphid, Macrosiphum euphorbiae potato aphid, Myzuspersicae green peach aphid, peach potato aphid, Rhopalosiphumpadi bird cherry oat aphid, Schizaphis graminum greenbug, Sitobion avenae English grain aphid, Toxoptera citricida browncitrus aphid, oriental citrus aphid, Empoasca vitis green frogfly, Idioscopus spp. mango leafhopper, Nilaparvata lugens rice brown planthopper, Aonidiella aurantii citrus scale), Euschistus spp. brownstinkbugs), Diaphorina citri Asian citrus psyllid, Paratriozacockerelli potato psyllid, tomato psyllid, Scirpophagaincertulas yellow (rice) stemborer, Anarsia lineatella peach twigborer, Tuta absoluta tomato leafminer, Leucopteracoffeella white coffee leafminer, Alabama argillacea cottonleafworn, Helicoverpa armigera American bollworm, cotton bollworm, Helicoverpa punctigera climbing cutworm, Heliothis virescens tobacco budworm, Helicoverpa zea corn earworm earworm), Pseudoplusia includens soybean looper, Sesamia inferenspink (rice) stem borer, Spodoptera eridania southern armyworm, Spodoptera exigua beet armyworm, Spodoptera frugiperda fallarmyworm, Spodoptera littoralis cotton leafworm, Spodopteralitura cluster caterpillar, Thermesia gemmatalis velvetbeancaterpillar, Trichoplusia ni cabbage looper, Phyllocnistis citrella citrus leafminer, Pieris brassicaecabbagebutterfly、large white、Pieris rapae imported cabbageworm、cabbage white、Plutella xylostella diamondback moth、Chilo suppressalis Asiatic rice stemborer、Cnaphalocerusmedinalis rice leaffolder、Leucinodes orbonalis brinjal fruitborer、Ostrinia furnicalis Asian corn borer、Ostrinia nubilalis European corn borer、Choristoneura rosaceana oblique-bandedleafroller、Eupoecilia ambiguella grape berry moth、Cydia pomonella codling moth、Grapholita molesta oriental fruitmoth, Lobesia botrana grape vine moth, Frankliniellafusca tobacco thrips, Frankliniella intonsa European flowerthrips, Frankliniella occidentalis western flower thrips, Scirthothrips citri citrus thrips, Scirthothrips dorsalis yellowtea thrips, chilli thrips, Thrips palmi melon thrips and Thrips tabaci onion thrips, common cotton thrips.

[0067] In some cyantraniliprole aspects of the present disclosure, the compositions of the present disclosure are effective against: Conotrachelus nenuphar plum curculio, Liromyza huidobrensis pealeafminer, Liriomyza sativae serpentine / vegetable leafminer, Liromyza trifolii American serpentine leafminer, Bemisia tabaci sweet potato whitefly, cotton whitefly, Trialeurodes vaporariorum, greenhouse whitefly, Acyrthosiphon pisumpea aphid, Aphis craccivora cowpea aphid, Aphis gossypii cottonaphid, melon aphid, Brevicoryne brassicae cabbage aphid, Dysaphis plantaginea rosy apple aphid, Myzus persicae green peach aphid, peach potato aphid, Diaphorina citri Asian citrus psyllid, Paratrioza cockerelli potato psyllid, tomato psyllid, Scirpophaga incertulas yellow (rice) stemborer, Anarsia lineatella peach twig borer, Tuta absoluta tomatoleafminer, Leucoptera coffeella white coffee leafminer, Alabama argillacea cotton leafworn, Helicoverpa armigera American cotton bollwormbollworm, cotton bollworm, Helicoverpa punctigeraclimbing cutworm, Heliothis virescens tobacco budworm, Helicoverpa zea corn earworm, Pseudoplusia includens soybean looper, Sesamia inferens pink (rice) stem borer, Spodoptera eridania southern armyworm, Spodoptera exigua beetarmyworm, Spodoptera frugiperda fall armyworm, Spodopteralittoralis cotton leafworm, Spodoptera litura cluster caterpillar, Phyllocnistis citrella citrus leafminer, Plutella xylostella diamondback moth, Chilo suppressalis Asiatic rice stemborer, Cnaphalocerus medinalis rice leaffolder, Choristoneura rosaceana oblique-banded leafroller, Eupoeciliaambiguella grape berry moth, Cydia pomonella codling moth, Grapholita molesta oriental fruit moth, Lobesia botrana grape vine moth, Frankliniella fusca tobacco thrips, Frankliniella occidentalis western flower thrips, Scirthothripsdorsalis yellow teathrips), chilli thrips, Thrips palmi melonthrips and Thrips tabaci onion thrips, common cottonthrips.

[0068] In terms of the chlorantraniliprole of the present disclosure, the composition of the present disclosure is effective against the following: Coleoptera (Chrysomelida, Leptinotarsa ​​decemlineata Colorado potato beetle, Curculionidae, Lissorhoptrusoryzophilus rice water weevil, Listronotus maculicollis annualbluegrass weevil, Oryzophagus oryzae rice water weevil, Sphenophorus spp. Billbug, Scarabaeidae Ataenius spretulus black turfgrass ataenius, Aphodius spp. scarab beetles, Cotinis nitida green June beetle, beetle, Cyclocephala spp. masked chafers, Exomala orientalis oriental beetle grub, Maladera castanea Asiatic garden beetle, Phyllophaga spp. June beetles, Popillia japonica Japanese beetle and Rhizotrogus majalis European chafer); Diptera (Agromyzidae, Chromatomyiahorticola garden pea leafminer and Liriomyza spp. Leafminers); Hemiptera (Aleyrodidae, Bemisia spp.Whitefly, Trialeurodes abutiloneus bandedwinged whitefly, Cicadellidae, and Typhlocyba pomaria white appleleafhopper); Isoptera (Rhinotermitidae, Heterotermestenuis sugarcane termite, Termitidae, Microtermes obesisugarcane termite, and Odontotermes obesus sugarcane termite); and Lepidoptera (Arctiidae, Estigmene acrea saltmarsh caterpillar, Crambidae, Achyra rantalis garden webworm, Desmia funeralis grape leaffolder, etc.). leaffolder), Ostrinia nubilalisEuropean corn borer, Gelechiidae, Anarsia lineatella peachtwig borer, Keiferia lycopersicella tomato pinworm, Phthorimaea operculella potato tuberworm, Tuta absolutaS.American tomato pinworm, Geometridae, Operophtherabrumata winter moth, Gracilaridae, Phyllocnistis citrellacitrus leafminer, Lithocolletis ringoniella apple leafminer, Phyllonorycter blancardella spotted tentiform leafminer, Lyonetidae, Leucoptera spp. (i.e., malifoliella, coffee leafminer), pear leaf blister moth, Noctuidae, Agrotis ipsilon black cutworm, Alabamaargillacea cotton leafworm, Amphipyra pyramidoides humped greenfruitworm), Anticarsia gemmatalis velvetbean caterpillar, Autographa gamma common silver Y moth, Barathra brassicae cabbagearmyworm, Earias spp. (i.e. huegeliana, insulana, vitella) rough, spiny, northern rough bollworm, Helicoverpa spp.(i.e., armigera, punctigera, zea) bollworms / budworms / fruitworms), Heliothis virescens tobacco budworm, Lithophane antennata green fruitworm, Mamestra brassicae cabbage moth, Orthosia hibisci green fruitworm, Phalaenoides glycinae grape vine moth, Phytometra acuta tomato semi-looper, Pseudoplusia includens soybean looper, Spodoptera spp. (i.e., exigua, frugiperda, littoralis) beet armyworm, fall armyworm, Egyptian cotton leafworm, Trichoplusia ni cabbage moth looper), Pieridae, Pieris spp. (i.e., brassica, rapae) large white, imported cabbageworm, Plutellidae, Plutella xylostella diamondbackmoth, Pyralidae, Amyelois transitella navel orangeworm, Chilo spp. (i.e., infuscatellus, polychrysus, suppressalis) sugarcane / rice stem borers, Cnaphalocrocis medinalis rice leafroller, Crambus spp. sod webworm, Crocidolomia binotalis cabbage clustercaterpillar, Diaphania species melon borer spp.(i.e., Hyalinata, Nitidalis) melonworm), pickleworm, Diatraea saccharalis, Brazilian sugarcane borer, Elasmopalpus lignosellus lesserstalk borer, Evergestis rimosalis cross-stripped cabbageworm, Hedylepta indicata soybean leaffolder, Hellula spp. (i.e., Hydralis, Undalis) cabbage centre-grub, cabbage webworm, Leucinodes orbonalis eggplant shoot and fruit borer, Maruca spp. pod borer, Neoleucinodes elegantalistomato small borer), Scirpophaga spp. sugarcane / rice stemborer, Sesamia spp. (i.e. inferens, nonagrioides) pink stemborer / corn stalk borer, Sphingidae, Manducaspp. (i.e. quinquemaculata, sexta) tomato / tobacco hornworm, Tortricidae, Adoxophyes orana summer fruit tortrix, Argyrotaenia spp. (i.e. pulchellana, velutinana) grape tortrix, redbanded leafroller, Bonagota cranaodes Brazilian appleleafroller), Carposina spp.niponensis, sasak peach fruit borer), peach fruit moth, Choristoneurarosaceana obliquebanded leafroller, Cryptophlebia leucotreta false codling moth, Cydia pomonella codling moth, Ecdytolopha aurantiana citrus borer, Endopiza vitana grapeberry moth, Epiphyas postvittana light brown apple moth, Eupoecilia ambiguella European grape berry moth, Grapholita molesta oriental fruit moth, Lobesia botrana European grapevine moth, Pandemis spp. (i.e., cerasana, heparana, barred fruit tree tortrix, limitata, pyrusana) apple brown tortrix), three-lined leafroller, (apple pandemic), Platynota spp. (i.e., idaeusalis, stultana) tufted apple bud moth, omnivorous leafroller, Zygaenidae, and Harrisina spp. (i.e., americana, brillian) grapeleaf / western grapeleaf skeletonizer.

[0069] In some chlorantraniliprole aspects of the present disclosure, the compositions of the present disclosure are effective against: Leptinotarsa ​​decemlineata Colorado potato beetle, Liriomyza spp. Leafminers, Bemisia spp. Whitefly, Trialeurodes abutiloneus bandedwinged whitefly, Heterotermestenuis sugarcane termite, Microtermes obesi sugarcane termite, and Odontotermes obesus sugarcane termite, Ostrinianubilalis European corn borer, Anarsia lineatella peach twig borer, Phthorimaea operculella potato tuberworm, Tutaabsoluta S. American tomato pinworm), Phyllocnistis citrella citrusleafminer, Phyllonorycter blancardella spotted tentiformleafminer, Leucoptera spp. (i.e. malifoliella, coffeeella) coffee leafminer, Agrotis ipsilon black cutworm, Alabama argillacea cotton leafworm, Anticarsia gemmatalisvelvetbean caterpillar, Helicoverpa spp.(i.e., armigera, punctigera, zea) bollworms / budworms / fruitworms), Heliothis virescens tobacco budworm, Pseudoplusia includens soybean looper, Spodoptera spp. (i.e., exigua, frugiperda, littoralis) beet armyworm, (fall armyworm), Egyptian cotton leafworm, Trichoplusia ni cabbage looper, Pieris spp. (i.e., brassica, rapae) large white, imported cabbageworm, Plutella xylostella diamondback moth, Amyelois transitella navel orangeworm, Chilo spp. (i.e., infuscatellus, polychrysus, suppressalis) sugarcane / rice stem borers), Cnaphalocrocis medinalis riceleafroller, Diatraea saccharalis, Brazilian sugarcaneborer, Leucinodes orbonalis eggplant shoot and fruit borer, Scirpophaga spp. sugarcane / rice stem borer, Sesamia spp. (i.e., inferens, nonagrioides) pink stem borer / corn stalk borer, Carposina spp.niponensis, sasaki peach fruit borer), peach fruit moth, Choristoneura rosaceana obliquebanded leafroller, Cydia pomonella codling moth, Eupoecilia ambiguella European grape berry moth, Grapholitamolesta oriental fruit moth, and Lobesia botrana European grapevine moth.

[0070] In some chlorantraniliprole aspects of the present disclosure, the compositions of the present disclosure are effective against: Liriomyza spp. Leafminers, Bemisia spp. Whitefly, Trialeurodes abutiloneus bandedwinged whitefly, Heterotermes tenuis sugarcane termite, Microtermes obesi sugarcane termite, and Odontotermes obesus sugarcane termite, Ostrinia nubilalis European corn borer, Anarsia lineatella peach twig borer, Tuta absoluta S. American tomato pinworm, Anticarsia gemmatalis velvet bean borer, caterpillar), Helicoverpa spp. (i.e., armigera, punctigera, zea) bollworms / budworms / fruitworms), Heliothis virescens tobacco budworm, Pseudoplusia includens soybean looper, Spodoptera spp. (i.e., exigua, frugiperda, littoralis) beet armyworm), (fall armyworm), Egyptian cotton leafworm, Plutella xylostella diamondback moth, Amyelois transitella navel orangeworm, Chilo spp.Infuscatellus, polychrysus, suppressalis sugarcane / rice stem borers), Cnaphalocrocis medinalis rice leafroller, Diatraea saccharalis, Brazilian sugarcane borer, Scirpophaga spp. sugarcane / rice stem borer, Cydia pomonella codling moth, Grapholita molesta oriental fruit moth and Lobesia botrana European grapevine moth.

[0071] plant

[0072] Therefore, these compositions of the present invention can be used to protect agronomic field crops, other non-agronomic horticultural crops and plants from the infringement of herbivorous invertebrate pests. This utility includes protecting crops and other plants (i.e., agronomy and non-agronomy) containing genetic materials introduced by genetic engineering (i.e., transgenic) or modified by mutagenesis to provide favorable traits. Examples of such traits include tolerance to herbicides, resistance to herbivorous pests (e.g., insects, mites, aphids, spiders, nematodes, snails, plant pathogenic fungi, bacteria and viruses), improved plant growth, increased tolerance to adverse growth conditions (such as high or low temperatures, low soil moisture or high soil moisture, and high salinity), increased flowering or fruiting, greater harvest yields, faster maturation, higher quality and / or nutritional value of harvested products, or improved storage or processing characteristics of harvested products. Transgenic plants can be modified to express a variety of traits. Examples of plants containing traits provided by genetic engineering or mutagenesis include corn, cotton, soybean and potato varieties expressing Bacillus thuringiensis insecticidal toxins, such as YIELD and INVICTA RR2 PRO TM , and herbicide-tolerant corn, cotton, soybean, and canola varieties, such as ROUNDUP LIBERTY and As well as crops expressing N-acetyltransferase (GAT) to provide resistance to glyphosate herbicides, or crops containing HRA genes that provide resistance to herbicides that inhibit acetolactate synthase (ALS). The compositions of the present invention can interact synergistically with traits introduced by genetic engineering or modified by mutagenesis to enhance the phenotypic expression or effectiveness of the traits, or increase the invertebrate pest control effectiveness of the compounds and compositions of the present invention. Specifically, the compositions of the present invention can interact synergistically with the phenotypic expression of proteins or other natural products that are toxic to invertebrate pests to provide greater than additive control of these pests, i.e., produce a combined effect greater than the sum of their individual effects.

[0073] Plants within the scope of the present disclosure include crops, vegetables, fruits, trees other than fruit trees, lawns and other uses (flowers, biofuel plants and ornamental foliage). Crops include: corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, sugar beets, rapeseed, sunflowers, sugar cane, tobacco and other crops known in the art. Vegetables include: Solanaceae vegetables (e.g., eggplant, tomato, bell pepper, pepper, and potato); Cucurbitaceae vegetables (e.g., cucumber, pumpkin, zucchini, watermelon, and melon); Cruciferae vegetables (e.g., Japanese radish, white radish, horseradish, Brussels sprouts, Chinese cabbage, kale, mustard greens, broccoli, and cauliflower); Asteraceae vegetables (e.g., burdock, chrysanthemum, artichoke, and lettuce); Liliaceae vegetables (e.g., green onion, onion, garlic, and asparagus); Apiaceae vegetables (e.g., carrot, parsley, celery, and parsnip); Chenopodiaceae vegetables (e.g., spinach and Swiss chard); and Mint family vegetables (e.g., basil, mint, and basil). Fruits include: pome fruits (e.g., apples, pears, Japanese pears, tangerines, plums, cherries, apricots, and prunes); hard-fleshed fruits (e.g., peaches, plums, nectarines, apricots, cherry fruits, apricots, and prunes); citrus fruits (e.g., mandarins, oranges, lemons, limes, and grapefruits); nuts (e.g., chestnuts, walnuts, hazelnuts, almonds, pistachios, cashews, and macadamia nuts); berry fruits (e.g., blueberries, cranberries, blackberries, strawberries, and raspberries); grapes; kaki; persimmon; olives; Japanese plums; bananas; coffee; date palms; coconuts; and oil palms. Trees other than fruit trees include: tea; mulberry; and other trees (e.g., ash, birch, dogwood, eucalyptus, ginkgo, lilac, maple, oak, poplar, Judas tree, sweet gum, plane tree, beech, Japanese arborvitae, fir, hemlock, juniper, pine, spruce, northeastern yew, elm and Japanese horse chestnut, coral tree, podocarp, Japanese cedar, Japanese cypress, croton, Japanese sea euonymus and photinia). Lawn uses include: turf (e.g., zoysia, abaca); bermudagrass; chaff; fescue; ryegrass. Flowers include: roses, carnations, chrysanthemums, lisianthus, baby's breath, gerberas, marigolds, sage, petunias, verbena, tulips, asters, gentians, lilies, pansies, cyclamen, orchids, lily of the valley, lavender, violets, ornamental cabbages, primroses, poinsettias, gladiolus, cattleyas, daisies, orchids, and begonias. Plants for biofuels include: jatropha, safflower, camelina, switchgrass, migratoria, phalaenopsis, arundo donax, kenaf, cassava, and willow.

[0074] Non-agricultural uses

[0075] Non-agricultural uses refer to invertebrate pest control in areas outside of crop plant fields. Non-agricultural uses of the compositions of the present invention include invertebrate pest control in stored grains, beans and other foods and textiles such as clothing and carpets. Non-agricultural uses of the compositions of the present invention also include invertebrate pest control in ornamental plants, forests, gardens, roadsides and railroad lands and turf such as lawns, golf courses and pastures. Non-agricultural uses of the compositions of the present invention also include invertebrate pest control in houses and other buildings that may be occupied by humans and / or companion animals, farm animals, ranch animals, zoo animals or other animals. Non-agricultural uses of the compositions of the present invention also include the control of pests such as termites that may damage wood or other structural materials used in buildings.

[0076] The non-agricultural uses of the composition of the present invention also include protecting human and animal health by preventing and controlling invertebrate pests that parasitize or spread infectious diseases. The prevention and control of animal parasites includes preventing and controlling external parasites that parasitize on the surface of the host animal (e.g., shoulders, armpits, abdomen, inner thighs) and internal parasites that parasitize in the host animal (e.g., stomach, intestines, lungs, veins, subcutaneous, lymphatic tissue). External parasitic or disease-propagating pests include, for example, chiggers, ticks, lice, mosquitoes, flies, mites and fleas. Internal parasites include heartworms, hookworms and worms. The composition of the present disclosure is suitable for systemic and / or non-systemic prevention and control of parasites on animals or infections. The composition of the present disclosure is particularly suitable for resisting external parasitic or disease-propagating pests. The compositions of the present disclosure are suitable for combating parasites that infest the following animals: agricultural working animals, such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, hens, turkeys, ducks, geese and bees; pet animals and domestic animals, such as dogs, cats, pet birds and aquarium fish; and so-called laboratory animals, such as hamsters, guinea pigs, rats and mice. By combating these parasites, mortality and performance decline (in meat, milk, wool, fur, eggs, honey, etc.) are reduced, so the application of the compositions of the present disclosure allows more economical and simple animal husbandry.

[0077] Can handle all plants or any part of plant according to this disclosure.Term " plant " as used herein should be construed as all plants or plant population, for example as desired or undesirable wild plants or crop plants (comprising naturally occurring crop plants).Crop plants can be the plants that can be obtained by conventional breeding and optimization method or biotechnology and genetic engineering method or the combination of these methods, comprise transgenic plants and comprise the plant cultivars that can or can not be protected by plant breeders' rights.Plant parts should be construed as meaning all parts and the organ of plant above and below the ground, such as plumule, leaf, flower and root, and the example that can mention is leaf, needle leaf, stalk, stem, flower, fruit body, fruit and seed and root, tuber and rhizome.Plant parts also comprise harvesting material and vegetative and reproductive propagation material, for example cutting, tuber, rhizome, branch and seed.

[0078] The treatment of plants and plant parts with the compositions according to the present disclosure is carried out by direct contact with the plants or plant parts or by acting on the environment, habitat or storage space of the plants using conventional treatment methods. For example, the treatment as described herein can be carried out by dipping, spraying, evaporating, atomizing, broadcasting, spreading, injection, and in the case of propagation materials, in particular in the case of seeds, applying a coating comprising the composition (optionally with additional layers).

[0079] In one embodiment, the composition of the present disclosure is delivered to the plant aerially. In another embodiment, the composition of the present disclosure is delivered via an unmanned aerial vehicle (UAV).

[0080] Wild plant species and plant cultivars or those obtained by conventional biological breeding methods such as hybridization or protoplast fusion, and parts thereof, can be processed. Moreover, transgenic plants and plant cultivars, and parts thereof, obtained by genetic engineering methods, if appropriate in combination with conventional methods (genetically modified organisms), have been processed. Plants of plant cultivars commercially available or in use in each case are processed according to this disclosure. Plant cultivars should be understood to mean plants with novel characteristics ("traits"), which have been obtained by conventional breeding, mutagenesis or recombinant DNA technology. These can be cultivation types, biotypes or genotypes.

[0081] Transgenic plants and plant cultivars (obtained by genetic engineering) that can be treated according to the present disclosure include all plants that have obtained genetic material by genetic modification, which confers particularly advantageous, useful traits to these plants. Examples of such traits are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or water or soil salinity, increased flowering performance, easier harvesting, faster maturation, higher harvest yields, higher quality and / or higher nutritional value of harvested products, better storage stability and / or better processability of harvested products. More and particularly emphasized examples of such traits are better resistance of plants to harmful organisms of animals and microorganisms (such as insects, mites, plant pathogenic fungi, bacteria and / or viruses), and increased tolerance of plants to certain herbicidally active compounds. Examples of transgenic plants include important crop plants such as cereals (wheat, rice), corn, soybeans, potatoes, beets, tomatoes, peas and other vegetable varieties, cotton, tobacco, rapeseed and fruit plants (fruits are apples, pears, citrus fruits and grapes), with emphasis on corn, soybeans, potatoes, cotton, tobacco and rapeseed. Traits include increased resistance of plants to insects, spiders, nematodes and slugs and snails by toxins formed in the plant, in particular by genetic material from Bacillus thuringiensis (e.g. genes CryIA (a), CryIA (b), CryIA (c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF, and combinations thereof) ("Bt plants"). Other traits are increased resistance of plants to fungi, bacteria and viruses by systemic acquired tolerance (SAR), systemins, phytoalexins, elicitors and resistance genes and correspondingly expressed proteins and toxins. Traits also include increased tolerance of plants to certain herbicidally active compounds such as imidazolinone, sulfonylurea, glyphosate or phosphinotricin (e.g. "PAT" gene). The genes that confer the desired trait in question may also be present in combination with one another in transgenic plants. Examples of "Bt plants" include those sold under the trade name (e.g. corn, cotton, soybeans), (such as corn), (such as corn), (cotton), (cotton) and (potato) corn varieties, cotton varieties, soybean varieties and potato varieties sold under the trade name Roundup (glyphosate tolerant, e.g. corn, cotton, soybean), Liberty (tolerant to glufosinate, such as rapeseed), (resistant to imidazolinone) and Herbicide-tolerant plants (plants bred in a conventional manner for tolerance to herbicides) include those sold under the names The agricultural crop is selected from the group consisting of cereals, fruit trees, citrus fruits, pulses, horticultural crops, melons, oil plants, tobacco, coffee, tea, cocoa, sugar beets, sugar cane and cotton.

[0082] Depending on the plant species or plant cultivars, their location and growth conditions (soil, climate, vegetation period, diet), treatment according to the present disclosure may also result in superadditive ("synergistic") effects. Thus, for example, it is possible to reduce the application rate and / or broaden the activity spectrum and / or increase the activity of the substances and compositions that can be used according to the present disclosure, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or water or soil salinity, increased flowering performance, easier harvesting, faster maturation, higher harvest yields, higher quality and / or higher nutritional value of the harvested products, better storage stability and / or processability of the harvested products, which go beyond the actual expected effects.

[0083] Crops that can be protected with the compositions according to the present disclosure include, for example, cereals (wheat, barley, rye, oats, rice, corn, sorghum, etc.), fruit trees (apples, pears, plums, peaches, almonds, cherries, bananas, grapes, strawberries, raspberries, blackberries, etc.), citrus trees (oranges, lemons, tangerines, grapefruits, etc.), legumes (beans, peas, lentils, soybeans, etc.), vegetables (spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, eggplants, peppers, etc.), melons (pumpkin, zucchini, cucumbers, melons, watermelons, etc.), oil plants (sunflowers, rapeseed, peanuts, castor beans, coconuts, etc.), tobacco, coffee, tea, cocoa, sugar beets, sugar cane, and cotton.

[0084] For the protection of agricultural crops, the compositions of the disclosure may be applied to any part of the plant, or applied to the seeds before sowing, or applied to the soil in which the plants are growing.

[0085] Embodiments of the present disclosure include:

[0086] Embodiment 1. A dry composition comprising:

[0087] about 10 wt % to about 30 wt % of an active ingredient having a low melting point;

[0088] about 0.5 wt % to about 1.5 wt % of a wetting agent;

[0089] about 0 wt % to about 20 wt % of a binder;

[0090] about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent;

[0091] about 1.0 wt % to about 5.0 wt % of a dispersant;

[0092] about 0 wt % to about 2 wt % of a defoaming agent; and

[0093] About 55 wt % to about 90 wt % of a diluent.

[0094] Embodiment 2. The dry composition of embodiment 1, wherein the active ingredient is present in an amount ranging from about 20 wt % to about 30 wt %.

[0095] Embodiment 3. The dry composition of any one of embodiments 1-2, wherein the active ingredient has a melting point in the range of about 50°C to about 90°C.

[0096] Embodiment 4. The dry composition of any one of embodiments 1-3, wherein the active ingredient is a pesticide selected from the group consisting of insecticides, herbicides, nematicides, biopesticides, fungicides, and combinations thereof.

[0097] Embodiment 5. A dry composition as described in any one of embodiments 1-4, wherein the active ingredient is a pesticide selected from bifenthrin, crystalline bifenthrin, waxy bifenthrin, amorphous bifenthrin, kappa-bifenthrin and combinations thereof, the pesticide having a melting point in the range of about 50°C to about 90°C.

[0098] Embodiment 6. The dry composition of any one of embodiments 1-5, wherein the wetting agent is selected from alkylnaphthalene sulfonates, lauryl sulfate, dodecylbenzene sulfonates, sulfosuccinates, and combinations thereof.

[0099] Embodiment 7. A dry composition as described in any one of embodiments 1-6, wherein the binder is selected from sugars, monosaccharides, glucose, dextrose, fructose, disaccharides, sucrose, lactose, lactose monohydrate, maltose, polysaccharides, starch, microcrystalline cellulose, chitin, and combinations thereof.

[0100] Embodiment 8. A dry composition as described in any one of embodiments 1-7, wherein the flow aid or anti-caking agent is selected from fumed silica, precipitated silica, a flow aid, magnesium silicate monohydrate (talc), magnesium stearate, calcium silicate, sodium aluminum silicate, and combinations thereof.

[0101] Embodiment 9. The dry composition of any one of embodiments 1-8, wherein the dispersant is selected from acrylic polymer dispersants, polycarboxylic acid polymer dispersants, lignin sulfonates, sodium methyl oleyl taurate, and combinations thereof.

[0102] Embodiment 10. A dry composition as described in any one of embodiments 1-9, wherein the diluent is selected from talc, starch, microcrystalline cellulose, kaolin, sugar, monosaccharide, glucose, dextrose, fructose, disaccharide, sucrose, lactose, lactose monohydrate, maltose, polysaccharide, starch, microcrystalline cellulose, chitin, and combinations thereof.

[0103] Embodiment 11. The dry composition of any one of embodiments 1-10, wherein the dry composition is substantially free of water.

[0104] Embodiment 12. The dry composition of any of embodiments 1-11, wherein the dry composition comprises particles having a D90 in the range of about 10 μm to about 35 μm.

[0105] Embodiment 13. The dry composition of any of embodiments 1-12, wherein the dry composition comprises particles having a D90 in the range of about 5 μm to about 20 μm.

[0106] Embodiment 14. The dry composition of any one of embodiments 1-13, wherein the dry composition is in the form of a water dispersible granule (WG) formulation or a wettable powder (WP) formulation.

[0107] Embodiment 15. A method for preparing a dry composition, the method comprising:

[0108] A mixture is formed, the mixture comprising:

[0109] about 10 wt % to about 30 wt % of an active ingredient having a low melting point;

[0110] about 0.5 wt % to about 1.5 wt % of a wetting agent;

[0111] about 0 wt % to about 20 wt % of a binder;

[0112] about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent;

[0113] about 1.0 wt % to about 5.0 wt % of a dispersant;

[0114] about 0 wt % to about 2 wt % of a defoaming agent; and

[0115] about 55 wt % to about 90 wt % of a diluent;

[0116] grinding the mixture;

[0117] optionally wetting the mixture with water;

[0118] optionally kneading the mixture moistened with water;

[0119] optionally extruding the mixture moistened with water; and

[0120] The mixture is optionally dried.

[0121] Embodiment 16. The method of embodiment 15, wherein the method step of grinding the mixture comprises grinding the mixture to a particle size having a D90 in the range of about 5 μm to about 35 μm.

[0122] Embodiment 17. The dry composition of any one of embodiments 15-16, wherein the dry composition is substantially free of water.

[0123] Embodiment 18. A method of using a dry composition comprising:

[0124] about 10 wt % to about 30 wt % of an active ingredient having a low melting point;

[0125] about 0.5 wt % to about 1.5 wt % of a wetting agent;

[0126] about 0 wt % to about 20 wt % of a binder;

[0127] about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent;

[0128] about 1.0 wt % to about 5.0 wt % of a dispersant;

[0129] about 0 wt % to about 2 wt % of a defoaming agent; and

[0130] about 55 wt % to about 90 wt % of a diluent;

[0131] The method comprises using the dry composition to control pests.

[0132] Embodiment 19. The method of embodiment 18, wherein the pests are selected from agronomic pests, non-agronomic pests, vertebrate pests, invertebrate pests, insects, and combinations thereof.

[0133] Embodiment 20. The method of any one of embodiments 18-19, wherein the dry composition comprises no more than 2.5 wt % water.

[0134] Embodiment 21. The method of any one of embodiments 18-20, wherein the dry composition is substantially free of water.

[0135] Examples

[0136] Without further elaboration, it is believed that one skilled in the art can utilize the present disclosure to its fullest extent using the preceding description.Therefore, the following examples should be construed as merely illustrative, and not limiting of the present disclosure in any way.

[0137] Example 1. Dry formulation.

[0138] Dry formulations were prepared according to the compositions shown in Table 1. The table shows the weight percentage of each component in the formulation. The total dry weight of each formulation is 100 wt%. Each dry formulation was prepared via a dry grinding device.

[0139] Table 1. Dry preparations.

[0140]

[0141]

[0142] After processing, the dry formulations of Table 1 were evaluated. Their performance is evaluated in Table 2. The cumulative wet sieving % is for a 200 mesh screen and is measured after being placed at 54°C for two weeks. In the wet sieving evaluation, the formulation is added to water and mixed for a specified amount of time. The mixture is then poured onto the screen, and the cumulative wet sieving % is the amount retained on the screen, calculated as a percentage of the original sample weight. The smaller the value, the better the dispersion quality of the indicated formulation.

[0143] Table 2. Performance evaluation of dry formulations.

[0144]

[0145]

[0146] Inventive Examples E1-E11 were easily processed into fine powders and provided excellent cumulative wet sieving % values. In contrast, Comparative Examples CE1-CE3 were not easily processed into fine powders that could be made into a usable dry product.

[0147] It has been unexpectedly found that using the listed ingredient combination, high loadings of bifenthrin can be incorporated into dry formulations (such as WG formulations or WP formulations) with relative ease and good physical stability. The resulting dry composition has good dispersibility and storage stability.

[0148] This written description uses examples to illustrate the disclosure, including the best mode, and also to enable any person skilled in the art to practice the disclosure, including making and using any devices or systems and performing any incorporated methods. The patentable scope of the disclosure is defined by the claims, and may include other examples that occur to those skilled in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal language of the claims.

[0149] As used herein, the terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," "characterized by," or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation expressly stated. For example, a composition, mixture, process, or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, or method.

[0150] The transitional phrase "consisting of" excludes any unrecited element, step, or ingredient. If in a claim, this phrase will make the claim closed-ended, excluding materials other than those recited, except for impurities normally associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the preamble, the phrase limits only the elements recited in that clause; the claim as a whole does not exclude other elements.

[0151] The transitional phrase "consisting essentially of is used to qualify compositions or methods that include materials, steps, features, components, or elements in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristics of the claimed disclosure. The term "consisting essentially of is intermediate between "comprising" and "consisting of."

[0152] When a disclosure or a portion thereof is defined by an open-ended term such as "comprising," it should be readily understood that (unless otherwise indicated) the description should be interpreted as also using the term "consisting essentially of" or "consisting of" to describe such disclosure.

[0153] In addition, unless expressly stated to the contrary, "or" refers to an inclusive or rather than an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or exists) and B is false (or does not exist), A is false (or does not exist) and B is true (or exists), and both A and B are true (or exist).

[0154] Likewise, the indefinite article "a / an" before an element or component of the present disclosure is intended to be non-restrictive with respect to the number of instances (i.e., occurrences) of the element or component. Thus, "a / an" should be understood to include one or at least one, and the singular word form of an element or component also includes the plural, unless the number obviously means the singular.

[0155] It should also be understood that any numerical ranges listed herein include all values ​​from the lower limit to the upper limit. For example, if the weight ratio range is specified as 1:50, it is expected that values ​​such as 2:40, 10:30, or 1:3 are explicitly listed in this specification. These are only examples of specific intent, and all possible combinations of numerical values ​​between (and including) the lowest and highest values ​​listed will be considered to be explicitly stated in this application.

[0156] As used herein, the term "about" means plus or minus 10% of the value.

Claims

1. A dry composition comprising: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to about 2 wt % of a defoaming agent; and About 55 wt % to about 90 wt % of a diluent.

2. The dry composition according to claim 1, wherein The active ingredient is present in an amount ranging from about 20 wt % to about 30 wt %.

3. The dry composition according to any one of claims 1 to 2, wherein The active ingredient has a melting point in the range of about 50°C to about 90°C.

4. The dry composition according to any one of claims 1 to 3, wherein The active ingredient is a pesticide selected from the group consisting of insecticides, herbicides, nematicides, biopesticides, fungicides, and combinations thereof.

5. The dry composition according to any one of claims 1 to 4, wherein The active ingredient is a pesticide selected from the group consisting of bifenthrin, crystalline bifenthrin, waxy bifenthrin, amorphous bifenthrin, kappa-bifenthrin, and combinations thereof, the pesticide having a melting point in the range of about 50°C to about 90°C.

6. The dry composition according to any one of claims 1 to 5, wherein The wetting agent is selected from the group consisting of alkylnaphthalene sulfonates, lauryl sulfates, dodecylbenzene sulfonates, sulfosuccinates, and combinations thereof.

7. A dry composition according to any one of claims 1 to 6, wherein The binder is selected from the group consisting of sugars, monosaccharides, glucose, dextrose, fructose, disaccharides, sucrose, lactose, lactose monohydrate, maltose, polysaccharides, starch, microcrystalline cellulose, chitin, and combinations thereof.

8. A dry composition according to any one of claims 1 to 7, wherein The flow aid or anti-caking agent is selected from fumed silica, precipitated silica, a flow aid, magnesium silicate monohydrate (talc), magnesium stearate, calcium silicate, sodium aluminum silicate, and combinations thereof.

9. The dry composition according to any one of claims 1 to 8, wherein The dispersant is selected from acrylic polymer dispersants, polycarboxylic acid polymer dispersants, lignin sulfonates, sodium methyl oleyl taurate, and combinations thereof.

10. The dry composition according to any one of claims 1 to 9, wherein The diluent is selected from the group consisting of talc, starch, microcrystalline cellulose, kaolin, sugar, monosaccharide, glucose, dextrose, fructose, disaccharide, sucrose, lactose, lactose monohydrate, maltose, polysaccharide, starch, microcrystalline cellulose, chitin, and combinations thereof.

11. The dry composition according to any one of claims 1 to 10, wherein The dry composition is substantially free of water.

12. The dry composition according to any one of claims 1 to 11, wherein The dry composition comprises particles having a D90 in the range of about 5 μm to about 35 μm.

13. A dry composition according to any one of claims 1 to 12, wherein The dry composition comprises particles having a D90 in the range of about 5 μm to about 20 μm.

14. A dry composition according to any one of claims 1 to 13, wherein The dry composition is in the form of a water dispersible granule (WG) formulation or a wettable powder (WP) formulation.

15. A method for preparing a dry composition, the method comprising: A mixture is formed, the mixture comprising: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to about 2 wt % of a defoaming agent; and about 55 wt % to about 90 wt % of a diluent; grinding the mixture; optionally wetting the mixture with water; optionally kneading the mixture moistened with water; optionally extruding the mixture moistened with water; and The mixture is optionally dried.

16. The method of claim 15, wherein: The method step of milling the mixture includes milling the mixture to a particle size having a D90 in the range of about 5 μm to about 35 μm.

17. A dry composition according to any one of claims 15 to 16, wherein The dry composition is substantially free of water.

18. A method of using a dry composition comprising: about 10 wt % to about 30 wt % of an active ingredient having a low melting point; about 0.5 wt % to about 1.5 wt % of a wetting agent; about 0 wt % to about 20 wt % of a binder; about 0.5 wt % to about 30 wt % of a flow aid or anti-caking agent; about 1.0 wt % to about 5.0 wt % of a dispersant; about 0 wt % to about 2 wt % of a defoaming agent; and about 55 wt % to about 90 wt % of a diluent; The method comprises using the dry composition to control pests.

19. The method of claim 18, wherein: The pests are selected from the group consisting of agronomic pests, non-agronomic pests, vertebrate pests, invertebrate pests, insects, and combinations thereof.

20. The method according to any one of claims 18 to 19, wherein: The dry composition is substantially free of water.

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