Liquid phase pump calibration method, device and liquid phase pump

Abstract

The present application provides a liquid phase pump calibration method, device and liquid phase pump, relating to the technical field of liquid phase pumps. The method includes: determining a relationship curve according to the correspondence between each sample flow rate and the corresponding main discharge point position; determining a target main cam curve and an intermediate sub-cam curve according to the current flow rate, the relationship curve, the initial main cam curve and the initial sub-cam curve; determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the sub-cam according to the current step position, the phase error, the target main cam curve and the intermediate sub-cam curve; and adjusting the driving speed corresponding to the next position according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the sub-cam and the current flow rate. The present application eliminates the pressure progressive error caused by flow rate coupling by determining the target main cam curve and the intermediate sub-cam curve, and eliminates the pressure pulsation caused by machining and assembly errors by adjusting the driving speed corresponding to the next position according to the phase error.

Description

Technical Field

[0001] The present application relates to the technical field of liquid pumps, and more particularly, to a liquid pump calibration method, device, and liquid pump. Background Art

[0002] The liquid pump is the power device of the liquid chromatograph. Among them, the liquid pump includes a cam liquid pump. The cam liquid pump drives the plunger to reciprocate through the rotation of the main and auxiliary cams, so as to transfer the solvent from the liquid storage bottle to the detector for detection. Each of the main and auxiliary cams has a design zero point and a detection zero point. During the operation of the liquid pump, aligning the design zero point and the detection zero point of the main and auxiliary cams, and aligning the phases of the main and auxiliary cams can ensure the stability of the system pressure.

[0003] With the change of the flow rate of the infusion pump, the pulsation at the non-opening point position shows a regular movement. This progressive error caused by the coupled flow rate may lead to errors between the design zero point and the detection zero point, resulting in periodic pulsation of the system pressure of the liquid pump, and further affecting the accuracy of the analysis and detection results of the liquid chromatograph. In addition, due to the machining error and assembly error of the cam and other fittings in the liquid pump, it may cause the plunger rod corresponding to the main cam and the plunger rod corresponding to the auxiliary cam to not correspond to the main cam curve and the auxiliary cam curve during the working process, resulting in a phase error, which will also cause periodic pulsation of the system pressure of the liquid pump. Summary of the Invention

[0004] The purpose of the present application is to provide a liquid pump calibration method, device, and liquid pump for solving the problem of system pressure fluctuation in the prior art in view of the above deficiencies in the prior art.

[0005] To achieve the above purpose, the technical solutions adopted in the present application are as follows:

[0006] In the first aspect, the present application provides a liquid pump calibration method, and the method includes:

[0007] Determine the main discharge point positions corresponding to multiple sample flow rates, and fit and determine a relationship curve according to the corresponding relationship between each sample flow rate and the main discharge point position. The relationship curve is used to characterize the mapping relationship between the flow rate and the main discharge point position;

[0008] According to the current flow rate of the solvent in the liquid pump, the relationship curve, the initial main cam curve, and the initial auxiliary cam curve, determine the target main cam curve and the intermediate auxiliary cam curve. The initial main cam curve and the initial auxiliary cam curve are respectively generated according to the actual equipment configuration information of the liquid pump. The initial main cam curve characterizes the corresponding relationship between the step position of the main cam in the liquid pump and the displacement increment of the main cam, and the initial auxiliary cam curve characterizes the corresponding relationship between the step position of the auxiliary cam in the liquid pump and the displacement increment of the auxiliary cam;

[0009] Determine the theoretical displacement increment of the main cam and the theoretical displacement increment of the auxiliary cam according to the current step position of the main cam and the auxiliary cam, the phase error between the main cam and the auxiliary cam, the target main cam curve, and the intermediate auxiliary cam curve;

[0010] Adjust the driving speed corresponding to the next position of the current step position according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam, and the current flow rate.

[0011] Optionally, the determining the target main cam curve and the intermediate auxiliary cam curve according to the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve, and the initial auxiliary cam curve includes:

[0012] Determine the current main discharge point position according to the current flow rate and the relationship curve;

[0013] Determine the theoretical main discharge point position according to the initial main cam curve and the initial auxiliary cam curve;

[0014] Determine the target main cam curve and the intermediate auxiliary cam curve according to the current main discharge point position, the theoretical main discharge point position, the initial main cam curve, and the initial auxiliary cam curve.

[0015] Optionally, the determining the target main cam curve and the intermediate auxiliary cam curve according to the current main discharge point position, the theoretical main discharge point position, the initial main cam curve, and the initial auxiliary cam curve includes:

[0016] Calculate the difference between the current main discharge point position and the theoretical main discharge point position to obtain a position difference;

[0017] Determine whether the current main discharge point position is less than the theoretical main discharge point position;

[0018] If so, move the initial main cam curve and the initial auxiliary cam curve in the first direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve;

[0019] If not, move the initial main cam curve and the initial auxiliary cam curve in the second direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve.

[0020] Optionally, the determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the auxiliary cam according to the current step position of the main cam and the auxiliary cam, the phase error between the main cam and the auxiliary cam, the target main cam curve, and the intermediate auxiliary cam curve includes:

[0021] Determine the theoretical displacement increment of the main cam corresponding to the current stepping position according to the current stepping position and the target main cam curve;

[0022] Determine the target sub-cam curve according to the phase error and the intermediate sub-cam curve;

[0023] Determine the theoretical displacement increment of the sub-cam according to the current stepping position and the target sub-cam curve.

[0024] Optionally, the determining the target sub-cam curve according to the phase error and the intermediate sub-cam curve includes:

[0025] Judge whether the phase error is greater than 0;

[0026] If so, move the intermediate sub-cam curve in the first direction by the phase error to obtain the target sub-cam curve;

[0027] If not, move the intermediate sub-cam curve in the second direction by the phase error to obtain the target sub-cam curve.

[0028] Optionally, the determining the main discharge point positions corresponding to multiple sample flow rates includes:

[0029] Operate the liquid-phase pump at a first flow rate, where the first flow rate is any one of the multiple sample flow rates;

[0030] Collect the system pressures at the main discharge point error observation positions when multiple candidate position points are used as the main discharge point positions under multiple cycles, where the candidate position points are non-opening point positions;

[0031] Take the candidate position point corresponding to the minimum system pressure pulsation at the main discharge point error observation position under multiple cycles as the main discharge point position corresponding to the first flow rate.

[0032] Optionally, adjusting the driving speed corresponding to the next position of the current stepping position according to the current stepping position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the sub-cam, and the current flow rate includes:

[0033] Determine the sum of the cam displacement increments according to the current stepping position, the theoretical displacement increment of the main cam, and the theoretical displacement increment of the sub-cam;

[0034] Determine the driving speed corresponding to the next position according to the current flow rate, the sum of the cam displacement increments, and the area of the plunger cross-section of the liquid-phase pump.

[0035] Optionally, the determining the sum of the cam displacement increments according to the current stepping position, the theoretical displacement increment of the main cam, and the theoretical displacement increment of the sub-cam includes:

[0036] Determine whether the main cam is in the liquid suction state at the current step position;

[0037] If so, use the theoretical displacement increment of the secondary cam as the sum of the cam displacement increments;

[0038] If not, use the vector sum of the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam as the sum of the cam displacement increments.

[0039] In a second aspect, the present application provides a liquid phase pump calibration device, the device comprising:

[0040] A fitting module, configured to determine the main discharge point positions corresponding to multiple sample flow rates, and fit and determine a relationship curve according to the corresponding relationship between each of the sample flow rates and the main discharge point positions, the relationship curve being used to characterize the mapping relationship between the flow rate and the main discharge point positions;

[0041] A first calibration module, configured to determine a target main cam curve and an intermediate secondary cam curve according to the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve, and the initial secondary cam curve, the initial main cam curve and the initial secondary cam curve being generated respectively according to the actual equipment configuration information of the liquid phase pump, the initial main cam curve characterizing the corresponding relationship between the step position of the main cam in the liquid phase pump and the main cam displacement increment, and the initial secondary cam curve characterizing the corresponding relationship between the step position of the secondary cam in the liquid phase pump and the secondary cam displacement increment;

[0042] A second calibration module, configured to determine the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam according to the current step positions of the main cam and the secondary cam, the phase errors of the main cam and the secondary cam, the target main cam curve, and the intermediate secondary cam curve;

[0043] An adjustment module, configured to adjust the driving speed corresponding to the next position of the current step position according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the secondary cam, and the current flow rate.

[0044] In a third aspect, the present application provides a liquid phase pump, the liquid phase pump comprising a control module, a main cam module, a secondary cam module, a main transmission module, a secondary transmission module, a main pump head, and a secondary pump head, the control module being configured to execute the liquid phase pump calibration method as described in the first aspect, so as to adjust the driving speeds of the main cam module and the secondary cam module, the main cam module driving the main transmission module, so that the main transmission module drives the plunger in the main pump head to perform reciprocating motion to achieve liquid discharge and liquid suction, and the secondary cam module driving the secondary transmission module, so that the secondary transmission module drives the plunger in the secondary pump head to perform reciprocating motion to achieve liquid discharge and liquid suction.

[0045] The beneficial effects of the present application are as follows: By fitting and determining the relationship curve according to the corresponding relationship between the flow rates of each sample and the positions of the main discharge points, and then determining the target main cam curve and the intermediate sub-cam curve based on the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve, and the initial sub-cam curve, so as to align the design zero point and the detection zero point, and eliminate the pressure progressive error caused by flow rate coupling. Then, by determining the theoretical displacement increment of the main cam and the displacement increment of the sub-cam according to the current stepping positions, phase errors, target main cam curve, and intermediate sub-cam curve of the main cam and the sub-cam, and adjusting the driving speed corresponding to the next position, thus, through the method of phase compensation, the phase error caused by the accumulation of machining and assembly of pump body parts is corrected, and the pressure pulsation deviation is eliminated. Description of the Drawings

[0046] To more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative efforts.

[0047] Figure 1 It is a schematic structural diagram of the liquid phase pump provided by the embodiment of the present application;

[0048] Figure 2 It is a schematic flowchart of a liquid phase pump calibration method provided by the embodiment of the present application;

[0049] Figure 3 It is a schematic diagram of a cam curve provided by the embodiment of the present application;

[0050] Figure 4 It is a schematic flowchart of a method for determining the target main cam curve and the intermediate sub-cam curve provided by the embodiment of the present application;

[0051] Figure 5 It is another schematic flowchart of a method for determining the target main cam curve and the intermediate sub-cam curve provided by the embodiment of the present application;

[0052] Figure 6 It is a schematic flowchart of a method for determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the sub-cam provided by the embodiment of the present application;

[0053] Figure 7 It is a schematic flowchart of a method for determining the target sub-cam curve provided by the embodiment of the present application;

[0054] Figure 8 It is a schematic flowchart of a method for determining the position of the main discharge point provided by the embodiment of the present application;

[0055] Figure 9It is a schematic flow chart for determining the sum of cam displacement increments provided by an embodiment of the present application;

[0056] Figure 10 It is a schematic structural diagram of a liquid phase pump calibration device provided by an embodiment of the present application. Detailed implementation manners

[0057] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It should be understood that the accompanying drawings in the present application are only for the purposes of illustration and description, and are not used to limit the protection scope of the present application. In addition, it should be understood that the schematic drawings are not drawn to actual scale. The flowcharts used in the present application illustrate operations implemented according to some embodiments of the present application. It should be understood that the operations in the flowchart may not be implemented in sequence, and steps without logical context relationships may be reversed or implemented simultaneously. In addition, those skilled in the art can add one or more other operations to the flowchart or remove one or more operations from the flowchart under the guidance of the content of the present application.

[0058] In addition, the described embodiments are only some embodiments of the present application, rather than all embodiments. The components of the embodiments of the present application usually described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application claimed, but only represents the selected embodiments of the present application. All other embodiments obtained by those skilled in the art based on the embodiments of the present application without creative efforts belong to the protection scope of the present application.

[0059] It should be noted that the term "including" will be used in the embodiments of the present application to indicate the existence of the features stated thereafter, but does not exclude adding other features.

[0060] The cam liquid phase pump may include unit pumps, binary pumps, quaternary pumps, etc. In this application, the unit pump is taken as an example to introduce the liquid phase pump calibration method. Figure 1 It is a schematic structural diagram of a liquid phase pump provided by an embodiment of the present application. As Figure 1 shown, the liquid phase pump includes a control module, a main cam module, a sub-cam module, a main transmission module, a sub-transmission module, a main pump head, and a sub-pump head. The main pump head and the sub-pump head each include a plunger.

[0061] Among them, the control module is used to perform liquid phase pump calibration and control the main cam module and the sub-cam module to rotate respectively.

[0062] Specifically, the main cam module includes a main cam and a main cam driving unit, and the main cam driving unit drives the main cam to rotate. The main cam is mechanically connected to the main transmission module, and the main transmission module is mechanically connected to the plunger in the main pump head. The main cam driving unit receives the control signal from the control module and controls the rotation of the main cam, thereby driving the main transmission module. The main transmission module pushes the plunger in the main pump head to reciprocate. When the plunger moves backward, it sucks liquid, and when the plunger is pushed forward, it discharges liquid. It should be noted that during the design of the main cam and the sub-cam, the main cam curve and the sub-cam curve can be determined based on the extended lines of the main cam and the sub-cam. Among them, the main cam curve represents the corresponding relationship between the step position of the main cam in the liquid phase pump and the displacement increment of the main cam. The step position of the main cam can represent the step process of the main cam driving unit, and the displacement increment of the main cam can represent the displacement increment of the plunger in the main pump head driven by the main cam. The sub-cam curve represents the corresponding relationship between the step position of the sub-cam in the liquid phase pump and the displacement increment of the sub-cam. The step position of the sub-cam can represent the step process of the sub-cam driving unit, and the displacement increment of the sub-cam can represent the displacement increment of the plunger in the sub-pump head driven by the sub-cam.

[0063] The sub-cam module includes a sub-cam and a sub-cam driving unit, and the sub-cam driving unit drives the sub-cam to rotate. The sub-cam is mechanically connected to the sub-transmission module, and the sub-transmission module is mechanically connected to the plunger in the sub-pump head. The sub-cam driving unit receives the control signal from the control module and controls the rotation of the sub-cam, thereby driving the sub-transmission module. The sub-transmission module pushes the plunger in the sub-pump head to reciprocate. When the plunger moves backward, it sucks liquid, and when the plunger is pushed forward, it discharges liquid.

[0064] The main cam driving unit and the sub-cam driving unit operate based on the same operating cycle.

[0065] By the main pump head and the sub-pump head sucking and discharging liquid complementarily, continuous solvent output is achieved. In this process, the position where the liquid phase pump starts to discharge liquid when starting is the opening point position, and the position where the liquid phase pump stably discharges liquid is the main discharge point position.

[0066] With the change of the solvent flow rate in the infusion pump, when the main cam driving unit and the sub-cam driving unit are in a non-opening point position, the pulsation of the system pressure will show a regular movement. This progressive error caused by the coupled flow rate may lead to errors in the design zero point and the detection zero point, resulting in periodic pulsation of the system pressure of the liquid phase pump, and further affecting the accuracy of the analysis and detection results of the liquid chromatography instrument. The purpose of this application is to align the design zero point and the detection zero point by aligning the main discharge point position at different flow rates, so as to make the system pressure of the liquid phase pump stable and ensure the accuracy of the analysis and detection results of the liquid chromatography instrument. Among them, the design zero point is the zero point theoretically detected by the detection component configured in the pump body during the cam cycle operation, and the detection zero point is the zero point actually detected by the detection component configured in the pump body during the cam cycle operation.

[0067] In addition, machining errors, assembly errors of components such as cams in the liquid-phase pump, non-parallelism between the main drive module and the sub-cam module, radial drive errors between the main drive module and the sub-drive module, and machining errors of the pump body bracket may all cause the plunger rod corresponding to the main cam and the plunger rod corresponding to the sub-cam to fail to correspond to the main cam curve and the sub-cam curve during operation, resulting in a phase error, which will also cause periodic pulsation of the system pressure of the liquid-phase pump. In this application, the phase error between the main and sub-cams is compensated to eliminate the periodic pulsation of the system pressure of the liquid-phase pump.

[0068] Next, with reference to Figure 2 the specific process of a liquid-phase pump calibration method provided by this application will be introduced. Among them, Figure 2 is a schematic flow chart of a liquid-phase pump calibration method provided by an embodiment of this application.

[0069] S201. Determine the main discharge point positions corresponding to multiple sample flow rates, and fit and determine a relationship curve according to the correspondence between each sample flow rate and the main discharge point position. The relationship curve is used to characterize the mapping relationship between the flow rate and the main discharge point position.

[0070] Optionally, set multiple different sample flow rates in advance, and respectively detect and determine the main discharge point positions corresponding to each sample flow rate based on different sample flow rates. The main discharge point positions corresponding to different flow rates are different. Specifically, the greater the flow rate, the more the main discharge point position corresponding to the flow rate moves backward.

[0071] S202. Determine a target main cam curve and an intermediate sub-cam curve according to the current flow rate of the solvent in the liquid-phase pump, the relationship curve, the initial main cam curve, and the initial sub-cam curve. The initial main cam curve and the initial sub-cam curve are respectively generated according to the actual equipment configuration information of the liquid-phase pump. The initial main cam curve characterizes the correspondence between the stepping position of the main cam and the displacement increment of the main cam in the liquid-phase pump, and the initial sub-cam curve characterizes the correspondence between the stepping position of the sub-cam and the displacement increment of the sub-cam in the liquid-phase pump.

[0072] Among them, the initial main cam curve and the initial sub-cam curve are respectively generated according to the actual equipment configuration information of the liquid-phase pump. Specifically, the initial main cam curve and the initial sub-cam curve are measured based on the current actual equipment configuration of the liquid-phase pump. Figure 3 is a schematic diagram of a cam curve provided by an embodiment of this application. The initial main cam curve and the initial sub-cam curve in one stepping cycle can be as Figure 3 shown in Figure 3Among them, the initial main cam curve indicates that the main pump head completes liquid suction between the stepping position 1 and the stepping position 2 of the main cam, and completes liquid discharge between the stepping position 2 through the stepping position 5 and back to the stepping position 1. The initial secondary cam curve indicates that the secondary pump head completes liquid suction between the stepping position 2 through the stepping position 5 and back to the stepping position 1. The control module controls the main cam driving unit and the secondary cam driving unit to achieve driving based on the initial main cam curve and the initial secondary cam curve, so as to stabilize the system pressure of the current pump head. However, due to different flow rates, the main discharge point positions are different, which affects the periodic pressure pulsation. Therefore, it is necessary to adjust the initial main cam curve and the initial secondary cam curve based on the main discharge point position, so as to stabilize the periodic system pressure.

[0073] As an alternative implementation, the current main discharge point position can be determined according to the current flow rate of the solvent in the liquid phase pump and the relationship curve, and then the target main cam curve and the intermediate secondary cam curve can be determined according to the current main discharge point position, the initial main cam curve, and the initial secondary cam curve.

[0074] Among them, the target main cam curve is a curve obtained by moving the initial main cam curve in the first direction or the second direction. If no movement is required, the initial main cam curve is directly used as the target main cam curve. The intermediate secondary cam curve is a curve obtained by moving the initial secondary cam curve in the first direction or the second direction. If no movement is required, the initial secondary cam curve is directly used as the intermediate secondary cam curve. Among them, the first direction and the second direction are opposite to each other. For example, in Figure 3 it, moving in the first direction can mean moving to the left, and moving in the second direction can mean moving to the right.

[0075] Optionally, the control module controls the main cam driving unit and the secondary cam driving unit to achieve driving based on the target main cam curve and the intermediate secondary cam curve, which can eliminate the pressure progressive error caused by flow rate coupling.

[0076] As an alternative implementation, when the current flow rate changes, step S202 can be re-executed to determine a new target main cam curve and a new intermediate secondary cam curve. When the current flow rate does not change, the target main cam curve and the intermediate secondary cam curve do not need to be adjusted during the driving process.

[0077] S203. Determine the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam according to the current stepping positions of the main cam and the secondary cam, the phase error between the main cam and the secondary cam, the target main cam curve, and the intermediate secondary cam curve.

[0078] Among them, the phase error between the main cam and the auxiliary cam can be determined in advance according to the periodic pulsation of the system pressure at the phase error observation point during the actual operation of the liquid-phase pump. The phase error observation point can be the position of the design zero point. Specifically, at the design zero point, if the system pressure is on the rising trend, the phase error is set to be negative; if the system pressure is on the falling trend, the phase error is set to be positive. The greater the slope, the greater the absolute value of the phase error; the smaller the slope, the smaller the absolute value of the phase error. Exemplarily, the phase error observation point can be Figure 3 positions 5 to 1 in

[0079] Optionally, after determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the auxiliary cam, and finally adjusting the driving speed corresponding to the next position of the current stepping position, the system pressure for multiple cycles can also be collected based on the current phase error, and it is determined whether the system pressure at the phase error observation point is stable. If so, during the use of the liquid-phase pump, the driving speed can be determined based on the current phase error. If it is not stable, a new phase error is determined according to the system pressure pulsation condition, and steps S203 - S204 are re-executed until the system pressure at the phase error observation point is stable.

[0080] On the basis of determining the phase error between the main cam and the auxiliary cam, the target auxiliary cam curve is determined by moving the intermediate auxiliary cam curve, and then according to the current stepping position, the target main cam curve and the target auxiliary cam curve, the theoretical displacement increment of the main cam and the theoretical displacement increment of the auxiliary cam can be determined.

[0081] Among them, the phase error between the target auxiliary cam curve and the target main cam curve is eliminated, so the system pressure pulsation deviation caused by the processing and installation of liquid-phase pump fittings, etc. is eliminated.

[0082] S204. Adjust the driving speed corresponding to the next position of the current stepping position according to the current stepping position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam, and the current flow rate.

[0083] As an optional implementation manner, it is judged whether the main pump head is in the liquid suction position according to the current stepping position, so as to determine the cam displacement increment sum, and then the driving speed corresponding to the next position is determined according to the current flow rate, the cam position increment sum, and the liquid-phase pump hardware configuration parameters, so that the control module drives the main cam driving unit and the auxiliary cam driving unit based on this driving speed at the next position.

[0084] As an optional implementation manner, the above steps S203 - S204 can be executed regularly to eliminate the cam curve phase error caused by hardware errors.

[0085] In this embodiment, by fitting and determining a relationship curve according to the correspondence between the flow rates of each sample and the positions of the main discharge points, and then determining the target main cam curve and the intermediate sub-cam curve based on the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve, and the initial sub-cam curve, the design zero point and the detection zero point are aligned, and the pressure progressive error caused by flow rate coupling is eliminated. Then, by determining the theoretical displacement increment of the main cam and the displacement increment of the sub-cam based on the current step positions, phase errors, target main cam curve, and intermediate sub-cam curve of the main cam and the sub-cam, the driving speed corresponding to the next position is adjusted, so that the phase error caused by the accumulation of pump body part processing and assembly is corrected by means of phase compensation, and the pressure pulsation deviation is eliminated.

[0086] Figure 4 is a schematic flow chart of a process for determining a target main cam curve and an intermediate sub-cam curve provided by an embodiment of the present application. Refer to Figure 4 , and next, the specific steps for determining the target main cam curve and the intermediate sub-cam curve according to the current flow rate, the relationship curve, the initial main cam curve, and the initial sub-cam curve in step S202 above will be introduced:

[0087] S401. Determine the current main discharge point position according to the current flow rate and the relationship curve.

[0088] Optionally, during the actual use of the liquid phase pump, the user may need to adjust the solvent flow rate to complete the solvent detection. The current flow rate is the flow rate set by the user, and the current flow rate may be different from the sample flow rate.

[0089] Specifically, the current flow rate of the solvent is substituted into the relationship curve to obtain the current main discharge point position corresponding to the current flow rate.

[0090] S402. Determine the theoretical main discharge point position according to the initial main cam curve and the initial sub-cam curve.

[0091] Optionally, in the initial main cam curve, the point where the main cam starts to discharge liquid stably is used as the theoretical main discharge point position. Exemplarily, as Figure 3 in, position 2 is the theoretical main discharge point position.

[0092] S403. Determine the target main cam curve and the intermediate sub-cam curve according to the current main discharge point position, the theoretical main discharge point position, the initial main cam curve, and the initial sub-cam curve.

[0093] Specifically, the position difference of the main discharge point can be determined according to the current main discharge point position and the theoretical main discharge point position, and then the initial main cam curve and the initial sub-cam curve are simultaneously moved based on the position difference of the main discharge point to obtain the target main cam curve and the intermediate sub-cam curve.

[0094] In this embodiment, since the relationship curve is fitted based on multiple sample flow rates before the liquid phase pump is used, and the relationship curve represents the position of the main discharge point corresponding to each flow rate, during the use of the liquid phase pump, the current main discharge point position is determined according to the current flow rate and the relationship curve, avoiding the detection of the position of the main discharge point corresponding to the current flow rate, ensuring the normal use of the liquid phase pump and improving efficiency. Then, the theoretical main discharge point position is determined according to the initial main cam curve and the initial sub-cam curve, so as to determine the target main cam curve and the intermediate sub-cam curve, and eliminate the progressive error of the periodic system pressure at the current flow rate.

[0095] Further, Figure 5 FIG. is a schematic flow chart of another method for determining the target main cam curve and the intermediate sub-cam curve provided by the embodiment of the present application. Refer to Figure 5 FIG., the specific process of determining the target main cam curve and the intermediate sub-cam curve according to the current main discharge point position, the theoretical main discharge point position, the initial main cam curve and the initial sub-cam curve in step S403 is introduced as follows:

[0096] S501. Calculate the difference between the current main discharge point position and the theoretical main discharge point position to obtain the position difference.

[0097] Specifically, if the current main discharge point position is less than the theoretical main discharge point position, the difference is negative; if the current main discharge point position is greater than the theoretical main discharge point position, the difference is positive. Refer to Figure 3 FIG., position 1 is less than position 2, and position 5 is greater than position 4.

[0098] S502. Determine whether the current main discharge point position is less than the theoretical main discharge point position.

[0099] For example Figure 3 shown in FIG., if the current main discharge point position is on the left side of the theoretical main discharge point position, it means that the current main discharge point position is less than the theoretical main discharge point position; if the current main discharge point position is on the right side of the theoretical main discharge point position, it means that the current main discharge point position is greater than the theoretical main discharge point position.

[0100] S503. If so, move the initial main cam curve and the initial sub-cam curve in the first direction by the position difference to obtain the target main cam curve and the intermediate sub-cam curve.

[0101] Optionally, if the current main discharge point position is less than the theoretical main discharge point position, move the initial main cam curve and the initial sub-cam curve in the first direction by the distance of the position difference to obtain the target main cam curve and the intermediate sub-cam curve. Wherein, the first direction may be the left side or the direction less than the current step position.

[0102] Optionally, the initial main cam curve and the initial sub-cam curve move the same distance and in the same direction.

[0103] S504. If not, move the initial main cam curve and the initial secondary cam curve in the second direction by the position difference to obtain the target main cam curve and the intermediate secondary cam curve.

[0104] Optionally, if the current main discharge point position is greater than the theoretical main discharge point position, move the initial main cam curve and the initial secondary cam curve in the second direction by the distance of the position difference to obtain the target main cam curve and the intermediate secondary cam curve. Here, the second direction can be the right side or the direction greater than the current step position.

[0105] As an optional implementation, if the current main discharge point position is equal to the theoretical main discharge point position, the position difference is also 0, and the initial main cam curve and the initial secondary cam curve are respectively used as the target main cam curve and the intermediate secondary cam curve.

[0106] In this embodiment, the position difference is obtained based on the current main discharge point position and the theoretical main discharge point position, and then the initial main cam curve and the initial secondary cam curve are moved according to whether the current main discharge point position is less than the theoretical main discharge point position to obtain the target main cam curve and the intermediate secondary cam curve, thereby eliminating the periodic pressure pulsation caused by the flow rate.

[0107] Next, refer to Figure 6 The specific steps for determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam according to the current step positions of the main cam and the secondary cam, the phase error between the main cam and the secondary cam, the target main cam curve, and the intermediate secondary cam curve in step S203 above are introduced. Among them, Figure 6 is a schematic flow chart for determining the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam provided by an embodiment of the present application.

[0108] S601. Determine the theoretical displacement increment of the main cam corresponding to the current step position according to the current step position and the target main cam curve.

[0109] Optionally, substitute the current step position into the target main cam curve to determine the theoretical displacement increment of the main cam corresponding to the current step position.

[0110] S602. Determine the target secondary cam curve according to the phase error and the intermediate secondary cam curve.

[0111] As an optional implementation, move the intermediate secondary cam curve according to the phase error to obtain the target secondary cam curve. Among them, the phase difference between the target secondary cam curve and the target main cam curve is equal to the phase error.

[0112] S603. Determine the theoretical displacement increment of the secondary cam according to the current step position and the target secondary cam curve.

[0113] Optionally, bring the current step position into the target sub-cam curve to obtain the theoretical displacement increment of the sub-cam corresponding to the current step position.

[0114] In this embodiment, the theoretical displacement increment of the main cam is determined according to the current step position and the target main cam curve, the target sub-cam curve is determined according to the phase error and the intermediate sub-cam curve, and then the theoretical displacement increment of the sub-cam is determined according to the current setting position and the target sub-cam curve, so as to eliminate the phase error of the main and sub-cam curves caused by part processing and assembly errors, thereby eliminating the periodic system pressure pulsation.

[0115] Further, referring to Figure 7 , the steps of determining the target sub-cam curve according to the phase error and the intermediate sub-cam curve in step S602 above are as follows. Wherein, Figure 7 is a schematic flow chart of a method for determining a target sub-cam curve provided by an embodiment of the present application.

[0116] S701. Determine whether the phase error is greater than 0.

[0117] Optionally, the phase error is determined by observing the system pressure of multiple cycles in advance.

[0118] S702. If so, move the intermediate sub-cam curve in the first direction by the phase error to obtain the target sub-cam curve.

[0119] Optionally, if the phase error is greater than 0, move the intermediate sub-cam curve in the first direction by the phase error, where the first direction may be the left, that is, move in the direction smaller than the current step position, and the moving distance is the value of the phase error.

[0120] S703. If not, move the intermediate sub-cam curve in the second direction by the phase error to obtain the target sub-cam curve.

[0121] Optionally, if the phase error is less than 0, move the intermediate sub-cam curve in the second direction by the phase error, where the second direction may be the right, that is, move in the direction smaller than the current step position, and the moving distance is the value of the phase error.

[0122] In this embodiment, the intermediate sub-cam curve is moved based on the phase error to obtain the target sub-cam curve, thereby eliminating the periodic system pressure pulsation caused by part processing and assembly.

[0123] Next, referring to Figure 8 introduce the specific process of determining the main discharge point positions corresponding to multiple sample flow rates in step S201 above. Wherein, Figure 8 is a schematic flow chart of a method for determining the main discharge point position provided by an embodiment of the present application.

[0124] S801. Operate the liquid phase pump at the first flow rate, where the first flow rate is any one of multiple sample flow rates.

[0125] Specifically, multiple sample flow rates are determined in advance. The more the number of sample flow rates, the more accurate the relationship curve determined by fitting.

[0126] S802. Collect the system pressures at the main discharge point error observation positions when multiple candidate position points are used as the main discharge point positions under multiple cycles. The candidate position points are non-opening point positions.

[0127] Among them, the candidate position points can be any position points other than the opening point positions.

[0128] As an optional implementation manner, make the solvent in the liquid phase pump be transported at the first flow rate, select multiple candidate position points, respectively use each candidate position point as the main discharge point, and collect the pulsation conditions of the system pressures corresponding to each candidate position point, especially the pulsation conditions of the system pressures at the main discharge point error observation positions. Among them, the main discharge point error observation position can be the position where both the main and auxiliary cams suck or discharge liquid, and the pulsation of the system pressure at this position is relatively obvious. The main discharge point error observation position is, for example Figure 3 positions 3 to 4.

[0129] S803. Use the candidate position point corresponding to the minimum system pressure pulsation at the main discharge point error observation position under multiple cycles as the main discharge point position corresponding to the first flow rate.

[0130] Optionally, when using the candidate position point as the main discharge point position and the system pressure pulsation is the smallest at the main discharge point error observation position, the candidate position point can be used as the main discharge point position corresponding to the first flow rate.

[0131] In this embodiment, by operating the liquid phase pump at the first flow rate, collecting the system pressures of each candidate position point under multiple cycles, and determining the main discharge point position corresponding to the first flow rate according to the system pressure pulsation conditions under multiple cycles, the main discharge point position error at different flow rates can be determined, so as to adjust the driving speed based on the position error and eliminate the pressure progressive error.

[0132] As an optional implementation manner, the specific steps of adjusting the driving speed of the next position corresponding to the current stepping position in step S204 according to the current stepping position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam, and the current flow rate include:

[0133] Optionally, determine the sum of the cam displacement increments according to the current stepping position, the theoretical displacement increment of the main cam, and the theoretical displacement increment of the auxiliary cam.

[0134] As an alternative implementation, it is possible to determine whether the main cam is in the liquid suction position based on the current step position, and based on the determination result, the theoretical position increment of the main cam, and the theoretical displacement increment of the sub-cam, determine the sum of the cam displacement increments.

[0135] Among them, the sum of the cam displacement increments is the displacement increment effect corresponding to the superposition of the liquid suction and liquid discharge actions of the main pump head and the sub-pump head on the solvent. That is, Figure 1 the cam displacement increment corresponding to the solvent system pressure effect in the pipeline where the sub-pump head outputs the liquid.

[0136] Optionally, based on the current flow rate, the sum of the cam displacement increments, and the area of the plunger cross-section of the liquid phase pump, determine the driving speed corresponding to the next position.

[0137] Specifically, the solvent volume can be calculated based on the cam displacement increment and the area of the plunger cross-section of the liquid phase pump. Then, based on the current flow rate, the current step position, and the next step position, the driving speed can be determined, so that the main cam and the sub-cam drive the plunger to move according to the driving speed, and at the current flow rate, the sum of the displacement increments of the main cam and the sub-cam can achieve the effect of the sum of the cam displacement increments.

[0138] Furthermore, Figure 9 is a schematic flow diagram of determining the sum of the cam displacement increments provided by an embodiment of the present application. As Figure 9 shown, the following introduces the specific steps of how to determine the sum of the cam displacement increments based on the current step position, the theoretical displacement increment of the main cam, and the theoretical displacement increment of the sub-cam.

[0139] S901. Determine whether the main cam is in the liquid suction state at the current step position.

[0140] As an alternative implementation, it is possible to determine the displacement increment corresponding to the current step position on the target main cam curve. If the displacement increment is negative, it is determined that the main cam is in the liquid suction state. If the displacement increment is positive, it is determined that the main cam is in the liquid discharge state.

[0141] S902. If so, use the theoretical displacement increment of the sub-cam as the sum of the cam displacement increments.

[0142] Optionally, if the main cam is currently in the liquid suction state, the main cam does not have a pressure effect on the solvent output, and the theoretical displacement increment of the sub-cam is used as the sum of the cam displacement increments.

[0143] S903. If not, use the vector sum of the theoretical displacement increment of the main cam and the theoretical displacement increment of the sub-cam as the sum of the cam displacement increments.

[0144] Optionally, if the main cam is not in the liquid suction state currently, the main cam has a pressure effect on the solvent output. Then, the vector sum of the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam is used as the sum of the cam displacement increments. Exemplarily, when the theoretical displacement increment of the main cam is 3 and the theoretical displacement increment of the secondary cam is -1, the sum of the cam displacement increments is 2. When the theoretical displacement increment of the main cam is 3 and the theoretical displacement increment of the secondary cam is 1, the sum of the cam displacement increments is 4.

[0145] As an alternative implementation, if the main cam is not in the liquid suction position at the current step position, it is determined whether the main cam at the current step position is less than the opening point position. If so, the theoretical displacement increment of the secondary cam is used as the sum of the cam displacement increments. If not, the vector sum of the theoretical displacement increment of the main cam and the theoretical displacement increment of the secondary cam is used as the sum of the cam displacement increments. Here, the opening point position is the position where liquid drainage starts when the liquid phase pump starts.

[0146] In this embodiment, by determining the sum of the cam displacement increments according to whether the main cam is in the liquid suction state, the driving speed at the next position is determined based on the sum of the cam displacement increments, so as to make the pressure of the liquid phase pump system stable.

[0147] Based on the same inventive concept, an embodiment of the present application also provides a liquid phase pump correction device corresponding to the liquid phase pump correction method. Since the principle of problem-solving of the device in the embodiment of the present application is similar to that of the above-mentioned liquid phase pump correction method in the embodiment of the present application, the implementation of the device can refer to the implementation of the method, and the repeated parts will not be elaborated.

[0148] Refer to Figure 10 As shown in the figure, it is a schematic structural diagram of a liquid phase pump correction device provided by an embodiment of the present application. The device includes: a fitting module 1001, a first correction module 1002, a second correction module 1003, and an adjustment module 1004; where:

[0149] The fitting module 1001 is configured to determine the main discharge point positions corresponding to multiple sample flow rates, and fit and determine a relationship curve according to the corresponding relationship between each sample flow rate and the main discharge point position. The relationship curve is used to characterize the mapping relationship between the flow rate and the main discharge point position;

[0150] The first correction module 1002 is configured to determine a target main cam curve and an intermediate secondary cam curve according to the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve, and the initial secondary cam curve. The initial main cam curve and the initial secondary cam curve are respectively generated according to the actual device configuration information of the liquid phase pump. The initial main cam curve characterizes the corresponding relationship between the step position of the main cam in the liquid phase pump and the main cam displacement increment, and the initial secondary cam curve characterizes the corresponding relationship between the step position of the secondary cam in the liquid phase pump and the secondary cam displacement increment;

[0151] The second correction module 1003 is configured to determine a theoretical displacement increment of the main cam and a theoretical displacement increment of the auxiliary cam according to the current step positions of the main cam and the auxiliary cam, the phase error between the main cam and the auxiliary cam, the target main cam curve, and the intermediate auxiliary cam curve;

[0152] The adjustment module 1004 is configured to adjust the driving speed corresponding to the next position of the current step position according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam, and the current flow rate.

[0153] Optionally, the first correction module 1002 is specifically configured to:

[0154] Determine the current main discharge point position according to the current flow rate and the relationship curve;

[0155] Determine the theoretical main discharge point position according to the initial main cam curve and the initial auxiliary cam curve;

[0156] Determine the target main cam curve and the intermediate auxiliary cam curve according to the current main discharge point position, the theoretical main discharge point position, the initial main cam curve, and the initial auxiliary cam curve.

[0157] Optionally, the first correction module 1002 is specifically configured to:

[0158] Calculate the difference between the current main discharge point position and the theoretical main discharge point position to obtain a position difference;

[0159] Determine whether the current main discharge point position is less than the theoretical main discharge point position;

[0160] If so, move the initial main cam curve and the initial auxiliary cam curve in the first direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve;

[0161] If not, move the initial main cam curve and the initial auxiliary cam curve in the second direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve.

[0162] Optionally, the second correction module 1003 is specifically configured to:

[0163] Determine the theoretical displacement increment of the main cam corresponding to the current step position according to the current step position and the target main cam curve;

[0164] Determine the target auxiliary cam curve according to the phase error and the intermediate auxiliary cam curve;

[0165] Determine the theoretical displacement increment of the auxiliary cam according to the current step position and the target auxiliary cam curve.

[0166] Optionally, the second correction module 1003 is specifically configured to:

[0167] Determine whether the phase error is greater than 0;

[0168] If so, move the intermediate sub-cam curve in the first direction by the phase error to obtain the target sub-cam curve;

[0169] If not, move the intermediate sub-cam curve in the second direction by the phase error to obtain the target sub-cam curve.

[0170] Optionally, the fitting module 1001 is specifically configured to:

[0171] Operate the liquid-phase pump at a first flow rate, where the first flow rate is any one of the multiple sample flow rates;

[0172] Collect the system pressures at the main discharge point error observation positions when multiple candidate position points are used as the main discharge point positions under multiple cycles, where the candidate position points are non-opening point positions;

[0173] Use the candidate position point corresponding to the minimum system pressure pulsation at the main discharge point error observation position under multiple cycles as the main discharge point position corresponding to the first flow rate.

[0174] Optionally, the adjustment module 1004 is specifically configured to:

[0175] Determine the sum of the cam displacement increments according to the current step position, the main cam theoretical displacement increment, and the sub-cam theoretical displacement increment;

[0176] Determine the driving speed corresponding to the next position according to the current flow rate, the sum of the cam displacement increments, and the area of the plunger cross-section of the liquid-phase pump.

[0177] Optionally, the adjustment module 1004 is specifically configured to:

[0178] Determine whether the main cam is in the liquid suction state at the current step position;

[0179] If so, use the sub-cam theoretical displacement increment as the sum of the cam displacement increments;

[0180] If not, use the vector sum of the main cam theoretical displacement increment and the sub-cam theoretical displacement increment as the sum of the cam displacement increments.

[0181] For the description of the processing flow of each module in the device and the interaction flow between each module, reference may be made to the relevant descriptions in the above method embodiments, which will not be elaborated here.

[0182] An embodiment of the present application further provides a liquid phase pump, which includes a control module, a main cam module, a secondary cam module, a main transmission module, a secondary transmission module, a main pump head, and a secondary pump head. The control module is configured to execute a liquid phase pump calibration method to adjust the driving speeds of the main cam module and the secondary cam module. The main cam module drives the main transmission module, so that the main transmission module drives the plunger in the main pump head to reciprocate, realizing liquid discharge and liquid suction. The secondary cam module drives the secondary transmission module, so that the secondary transmission module drives the plunger in the secondary pump head to reciprocate, realizing liquid discharge and liquid suction.

[0183] The above are only specific embodiments of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present application can easily think of changes or substitutions, which should all be covered within the protection scope of the present application.

Claims

1. A liquid phase pump calibration method, characterized in that: The method comprises: Determine the main discharge point positions corresponding to multiple sample flow rates, and according to the corresponding relationship between each sample flow rate and the main discharge point position, fit and determine a relationship curve, wherein the relationship curve is used to characterize the mapping relationship between the flow rate and the main discharge point position, and the main discharge point position is the position where the liquid phase pump stably discharges liquid; Determine a target main cam curve and an intermediate auxiliary cam curve according to the current flow rate of the solvent in the liquid phase pump, the relationship curve, an initial main cam curve and an initial auxiliary cam curve, wherein the initial main cam curve and the initial auxiliary cam curve are respectively generated according to the actual device configuration information of the liquid phase pump, the initial main cam curve represents the corresponding relationship between the step position of the main cam in the liquid phase pump and the main cam displacement increment, and the initial auxiliary cam curve represents the corresponding relationship between the step position of the auxiliary cam in the liquid phase pump and the auxiliary cam displacement increment; Determine the main cam theoretical displacement increment and the auxiliary cam theoretical displacement increment according to the current step positions of the main cam and the auxiliary cam, the phase errors of the main cam and the auxiliary cam, the target main cam curve and the intermediate auxiliary cam curve; The driving speed corresponding to the next position of the current step position is adjusted according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam and the current flow rate.

2. The liquid phase pump calibration method according to claim 1, characterized in that: The step of determining a target main cam curve and an intermediate auxiliary cam curve according to the current flow rate of the solvent in the liquid phase pump, the relationship curve, the initial main cam curve and the initial auxiliary cam curve comprises: Determine the current main discharge point position according to the current flow velocity and the relationship curve; Determining a theoretical main cam point position according to the initial main cam curve and the initial auxiliary cam curve; A target main cam curve and an intermediate auxiliary cam curve are determined according to the current main cam point position, the theoretical main cam point position, the initial main cam curve and the initial auxiliary cam curve.

3. The liquid phase pump calibration method according to claim 2, characterized in that: The determining of a target main cam curve and an intermediate auxiliary cam curve according to the current main cam point position, the theoretical main cam point position, the initial main cam curve and the initial auxiliary cam curve comprises: Calculate the difference between the current main row point position and the theoretical main row point position to obtain the position difference; Determine whether the current main row point position is less than the theoretical main row point position; If yes, the initial main cam curve and the initial auxiliary cam curve are moved in a first direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve; If not, the initial main cam curve and the initial auxiliary cam curve are moved in the second direction by the position difference to obtain the target main cam curve and the intermediate auxiliary cam curve.

4. The liquid phase pump calibration method according to claim 1, characterized in that: The method of determining the main cam theoretical displacement increment and the auxiliary cam theoretical displacement increment according to the current step positions of the main cam and the auxiliary cam, the phase errors of the main cam and the auxiliary cam, the target main cam curve and the intermediate auxiliary cam curve comprises: Determining a theoretical displacement increment of the main cam corresponding to the current stepping position according to the current stepping position and the target main cam curve; Determining a target secondary cam curve according to the phase error and the intermediate secondary cam curve; The auxiliary cam theoretical displacement increment is determined according to the current step position and the target auxiliary cam curve.

5. The liquid phase pump calibration method according to claim 4, characterized in that: The step of determining a target secondary cam curve according to the phase error and the intermediate secondary cam curve comprises: Determine whether the phase error is greater than 0; If yes, the intermediate auxiliary cam curve is moved in the first direction by the phase error to obtain the target auxiliary cam curve; If not, the intermediate auxiliary cam curve is moved in the second direction by the phase error to obtain the target auxiliary cam curve.

6. The liquid phase pump calibration method according to claim 1, characterized in that: The determining of the main row point positions corresponding to the plurality of sample flow rates comprises: Running the liquid phase pump at a first flow rate, wherein the first flow rate is any one of the plurality of sample flow rates; Collecting the system pressure of the main arrangement point error observation position when multiple candidate positions are used as the main arrangement point positions under multiple cycles, wherein the candidate positions are non-opening point positions; The candidate position point corresponding to the minimum system pressure pulsation at the main discharge point error observation position under multiple cycles is used as the main discharge point position corresponding to the first flow rate.

7. The liquid phase pump calibration method according to claim 1, characterized in that: The step of adjusting the driving speed corresponding to the next position of the current step position according to the current step position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam, and the current flow rate includes: Determine the cam displacement increment sum according to the current step position, the main cam theoretical displacement increment and the auxiliary cam theoretical displacement increment; The driving speed corresponding to the next position is determined according to the current flow rate, the cam displacement increment and the area of ​​the plunger cross section of the liquid phase pump.

8. The liquid phase pump calibration method according to claim 7, characterized in that: Determining the sum of the cam displacement increments according to the current step position, the main cam theoretical displacement increment, and the auxiliary cam theoretical displacement increment comprises: Determining whether the main cam is in a liquid absorbing state at the current stepping position; If yes, the auxiliary cam theoretical displacement increment is used as the cam displacement increment sum; If not, the vector sum of the main cam theoretical displacement increment and the auxiliary cam theoretical displacement increment is used as the cam displacement increment sum.

9. A liquid phase pump calibration device, characterized in that: The device comprises: A fitting module is used to determine the main discharge point positions corresponding to a plurality of sample flow rates, and to fit and determine a relationship curve according to the corresponding relationship between each of the sample flow rates and the main discharge point positions, wherein the relationship curve is used to characterize the mapping relationship between the flow rate and the main discharge point position, and the main discharge point position is the position where the liquid phase pump stably discharges liquid; A first correction module, for determining a target main cam curve and an intermediate auxiliary cam curve according to a current flow rate of the solvent in the liquid phase pump, the relationship curve, an initial main cam curve and an initial auxiliary cam curve, wherein the initial main cam curve and the initial auxiliary cam curve are respectively generated according to actual device configuration information of the liquid phase pump, the initial main cam curve represents a corresponding relationship between a step position of a main cam in the liquid phase pump and a displacement increment of the main cam, and the initial auxiliary cam curve represents a corresponding relationship between a step position of an auxiliary cam in the liquid phase pump and a displacement increment of the auxiliary cam; A second correction module is used to determine the main cam theoretical displacement increment and the auxiliary cam theoretical displacement increment according to the current step positions of the main cam and the auxiliary cam, the phase errors of the main cam and the auxiliary cam, the target main cam curve and the intermediate auxiliary cam curve; The adjustment module is used to adjust the driving speed corresponding to the next position of the current stepping position according to the current stepping position, the theoretical displacement increment of the main cam, the theoretical displacement increment of the auxiliary cam and the current flow rate.

10. A liquid phase pump, characterized in that: The liquid phase pump includes a control module, a main cam module, a sub-cam module, a main transmission module, a sub-transmission module, a main pump head and a sub-pump head. The control module is used to execute the liquid phase pump calibration method as described in any one of claims 1 to 8, so as to adjust the driving speeds of the main cam module and the sub-cam module. The main cam module drives the main transmission module so that the main transmission module drives the plunger in the main pump head to reciprocate to achieve liquid discharge and liquid suction. The sub-cam module drives the sub-transmission module so that the sub-transmission module drives the plunger in the sub-pump head to reciprocate to achieve liquid discharge and liquid suction.

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