Sample analyzer and liquid suction control method

Abstract

The embodiment of the invention provides a sample analyzer and a liquid absorption control method, the sample analyzer is provided with a magnetic separation device and a controller, and the controller is used for controlling a liquid injection mechanism to execute liquid injection operation to a reaction container and controlling a magnetic adsorption mechanism to execute magnetic adsorption operation on magnetic particles in reaction liquid in the reaction container. And controlling the liquid suction mechanism to perform liquid suction operation on the liquid in the reaction container. Wherein the liquid suction operation at least comprises the following steps: controlling a first needle moving assembly of the liquid suction mechanism to drive a liquid suction needle to move below the liquid level in the reaction container, and controlling a first power assembly of the liquid suction mechanism to drive the liquid suction needle to execute liquid suction action; after the continuous liquid suction time of the liquid suction action reaches a preset time, controlling the first needle moving assembly to drive the liquid suction needle to move above the liquid level of the liquid in the reaction container; and after the liquid suction needle moves to the position above the liquid level of the liquid in the reaction container, the first power assembly is controlled to continuously drive the liquid suction needle to execute the liquid suction action.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and particularly to a sample analyzer and a liquid suction control method. Background Art

[0002] Taking an immunoassay analyzer as an example, it is a type of highly sensitive and highly specific analytical instrument, which is often used in clinical laboratories to detect various immune indexes in blood, urine or other body fluids. The principle is the combination of antibody-antigen reaction and chemiluminescence technologies to achieve high specificity and high sensitivity.

[0003] The main operation process in an immunoassay analyzer includes a magnetic separation and cleaning process. In the magnetic separation and cleaning process, small particles with magnetic materials on the surface are processed so that they can adsorb the required effective substances. Then, after being adsorbed and enriched by a magnet, a liquid injection mechanism is used to inject liquid for cleaning the enriched magnetic beads, and a liquid suction mechanism is used to suck the cleaning waste liquid to remove impurities on the surface of the magnetic beads, so that the effective substances required for detection are retained because they are adsorbed on the magnetic beads.

[0004] However, during the magnetic separation and cleaning process, the liquid suction mechanism may suck away some magnetic beads during the liquid suction process, resulting in magnetic loss, and the effective substances enriched on the magnetic beads are taken away together, thus affecting the accuracy of the detection results. Summary of the Invention

[0005] The main purpose of the embodiments of the present application is to provide a sample analyzer and a liquid suction control method, aiming to reduce the magnetic loss during the magnetic separation process of the sample analyzer to improve the accuracy of the detection results.

[0006] In a first aspect, the embodiments of the present application provide a sample analyzer, including:

[0007] A reaction solution preparation device for adding a sample and a reagent to a reaction container to prepare a reaction solution;

[0008] A reaction device provided with a reaction position for placing the reaction container and for providing an incubation place for the reaction solution in the reaction container;

[0009] A magnetic separation device for performing magnetic separation and cleaning on the reaction solution in the reaction container, and the magnetic separation device at least includes a magnetic adsorption mechanism for performing magnetic adsorption operation on magnetic particles in the reaction solution in the reaction container, a liquid injection mechanism for injecting a cleaning solution into the reaction container to clean impurities attached to the surface of the magnetic particles, and a liquid suction mechanism for performing a liquid suction operation on the liquid in the reaction container. Among them, the liquid suction mechanism includes a liquid suction needle, a first needle moving assembly for driving the liquid suction needle to move, a liquid suction pipeline connected to the liquid suction needle, and a first power assembly connected to the liquid suction needle through the liquid suction pipeline and for providing liquid suction power; and

[0010] A controller, communicatively connected to the magnetic separation device, and during the magnetic separation cleaning process of the magnetic separation device, the controller is configured to:

[0011] Control the liquid injection mechanism to perform a liquid injection operation on the reaction vessel, control the magnetic adsorption mechanism to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel, and control the liquid suction mechanism to perform a liquid suction operation on the liquid in the reaction vessel;

[0012] Wherein, the liquid suction operation at least includes: controlling the first needle moving assembly to drive the liquid suction needle to move below the liquid level in the reaction vessel, and controlling the first power assembly to drive the liquid suction needle to perform a liquid suction action;

[0013] After the continuous liquid suction time of the liquid suction action reaches a preset time, controlling the first needle moving assembly to drive the liquid suction needle to move above the liquid level of the liquid in the reaction vessel; and after the liquid suction needle moves above the liquid level of the liquid in the reaction vessel, controlling the first power assembly to continuously drive the liquid suction needle to perform a liquid suction action.

[0014] In a second aspect, an embodiment of the present application further provides a liquid suction control method, which is applied to a sample analyzer. The sample analyzer includes a reaction liquid preparation device and a magnetic separation device. The method includes:

[0015] Controlling the reaction liquid preparation device to add a sample and a reagent to the reaction vessel to prepare a reaction liquid;

[0016] Controlling the magnetic separation device to perform magnetic separation cleaning on the reaction vessel carrying the reaction liquid. The magnetic separation cleaning includes: controlling the liquid injection mechanism of the magnetic separation device to perform a liquid injection operation on the reaction vessel containing the reaction liquid, controlling the magnetic adsorption mechanism of the magnetic separation device to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel, and controlling the liquid suction mechanism of the magnetic separation device to perform a liquid suction operation on the liquid in the reaction vessel;

[0017] Wherein, the liquid suction operation at least includes: controlling the first needle moving assembly of the liquid suction mechanism to drive the liquid suction needle of the liquid suction mechanism to move below the liquid level in the reaction vessel, and controlling the first power assembly of the liquid suction mechanism to drive the liquid suction needle to perform a liquid suction action;

[0018] After the continuous liquid suction time of the liquid suction action reaches a preset time, controlling the first needle moving assembly to drive the liquid suction needle to move above the liquid level of the liquid in the reaction vessel; and after the liquid suction needle moves above the liquid level of the liquid in the reaction vessel, the first power assembly continuously drives the liquid suction needle to perform a liquid suction action.

[0019] The embodiments of the present application provide a sample analyzer and a liquid suction control method. The sample analyzer includes a reaction solution preparation device, a reaction device, a magnetic separation device, and a controller. The reaction solution preparation device is used to add a sample and a reagent to a reaction container to prepare a reaction solution. The reaction device is provided with a reaction position for placing the reaction container and is used to provide an incubation place for the reaction solution in the reaction container. The magnetic separation device is used to perform magnetic separation cleaning on the reaction solution in the reaction container. The magnetic separation device at least includes a magnetic adsorption mechanism for performing a magnetic adsorption operation on magnetic particles in the reaction solution in the reaction container, a liquid injection mechanism for performing a cleaning liquid injection operation on the reaction container to clean impurities attached to the surface of the magnetic particles, and a liquid suction mechanism for performing a liquid suction operation on the liquid in the reaction container. The liquid suction mechanism includes a liquid suction needle, a first needle movement component for driving the liquid suction needle to move, a liquid suction pipeline connected to the liquid suction needle, and a first power component connected to the liquid suction needle through the liquid suction pipeline and used to provide liquid suction power. And

[0020] A controller, communicatively connected to the magnetic separation device. During the magnetic separation cleaning process of the magnetic separation device, the controller is configured to: control the liquid injection mechanism to perform a liquid injection operation on the reaction container, control the magnetic adsorption mechanism to perform a magnetic adsorption operation on the magnetic particles in the reaction solution in the reaction container, and control the liquid suction mechanism to perform a liquid suction operation on the liquid in the reaction container. The liquid suction operation at least includes: controlling the first needle movement component to drive the liquid suction needle to move below the liquid level in the reaction container, and controlling the first power component to drive the liquid suction needle to perform a liquid suction action; after the continuous liquid suction time of the liquid suction action reaches a preset time, controlling the first needle movement component to drive the liquid suction needle to move above the liquid level of the liquid in the reaction container; and after the liquid suction needle moves above the liquid level of the liquid in the reaction container, controlling the first power component to continuously drive the liquid suction needle to perform a liquid suction action.

[0021] Based on the fact that the liquid suction operation of the liquid suction mechanism on the liquid in the reaction container during the magnetic separation process is one of the important reasons for magnetic loss, when the liquid suction mechanism performs a liquid suction operation on the liquid in the reaction container, after controlling the liquid suction needle to perform a liquid suction action below the liquid level in the reaction container for a preset time, then lifting the liquid suction needle above the liquid level, it is possible to avoid the liquid suction needle sucking away the magnetic beads in the reaction container for a long time below the liquid level, causing magnetic loss. Furthermore, it can effectively reduce the magnetic loss of the sample analyzer during the magnetic separation process, to a large extent retain the effective substances attached to the magnetic beads, and improve the accuracy of the detection results.

[0022] At the same time, after the liquid suction needle moves above the liquid level in the reaction container, since the liquid suction needle continuously performs a liquid suction action, the liquid in the liquid suction needle, or the liquid in the liquid suction needle and the liquid suction pipeline can be pumped out, so that the liquid suction mechanism can accurately suck the corresponding amount of liquid during the next liquid suction operation, realizing accurate liquid suction and reducing the overflow probability of the reaction container during the liquid injection process.

[0023] That is, if there is unextracted liquid in the liquid suction needle and the liquid suction pipeline during the magnetic separation process, it will cause the liquid suction amount of the liquid in the reaction vessel to be less than the preset liquid suction amount during the liquid suction operation of the liquid suction mechanism on the reaction vessel. That is, after the liquid suction mechanism completes the liquid suction operation, there is excessive remaining liquid in the reaction vessel, which in turn increases the probability of liquid overflow in the reaction vessel after the liquid injection mechanism performs the liquid injection operation, resulting in the liquid volume in the reaction vessel exceeding the volume of the reaction vessel.

[0024] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure of the embodiments of the present application. Brief Description of the Drawings

[0025] To more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0026] Figure 1 is the test principle diagram of the immunoassay performed by the sample analyzer;

[0027] Figure 2 is the block diagrammatic structural schematic diagram of the sample analyzer in one embodiment;

[0028] Figure 3 is the structural layout schematic diagram of the sample analyzer in one embodiment;

[0029] Figure 4 is the structural schematic diagram of the dispensing device of the sample analyzer in one embodiment;

[0030] Figure 5 is the block diagrammatic structural schematic diagram of the magnetic separation device of the sample analyzer in one embodiment;

[0031] Figure 6A is the block diagrammatic structural schematic diagram of the liquid suction mechanism of the sample analyzer in one embodiment;

[0032] Figure 6B is the block diagrammatic structural schematic diagram of the liquid injection mechanism of the sample analyzer in one embodiment;

[0033] Figure 6C is the scene schematic diagram of the liquid suction and injection of the liquid suction and injection component of the sample analyzer in one embodiment;

[0034] Figures 7A - 7B is the scene schematic diagram of the liquid suction operation of the liquid suction mechanism of the sample analyzer in one embodiment;

[0035] Figure 8 It is a schematic diagram of the scenario where the liquid suction mechanism of the sample analyzer in one embodiment performs two liquid suction operations on the same reaction vessel at the same operation position;

[0036] Figure 9A It is a schematic diagram of the scenario where the liquid suction mechanism and the liquid injection machine of the sample analyzer in one embodiment perform a liquid suction operation and a liquid injection operation respectively on the same reaction vessel at the same operation position;

[0037] Figure 9B It is a schematic diagram of the scenario where the liquid suction mechanism and the liquid injection machine of the sample analyzer in one embodiment perform a liquid suction operation and a liquid injection operation respectively on the same reaction vessel at different operation positions;

[0038] Figure 10 It is a schematic diagram of the scenario where the liquid suction mechanism of the sample analyzer in one embodiment performs two liquid suction operations on the same reaction vessel at different operation positions. Detailed implementation manners

[0039] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative efforts shall fall within the protection scope of the present application.

[0040] In the description of the present application, unless otherwise clearly defined and limited, the terms "installation", "connection", and "connection" shall be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be a direct connection or an indirect connection through an intermediate medium, and it may be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific situations.

[0041] The flowcharts shown in the accompanying drawings are only illustrative examples, and do not necessarily include all contents and operations / steps, nor do they necessarily need to be executed in the described order. For example, some operations / steps can also be decomposed, combined, or partially merged, so the actual execution order may be changed according to the actual situation.

[0042] Next, some embodiments of the present application will be described in detail in conjunction with the accompanying drawings. Without conflict, the features in the following embodiments and embodiments can be combined with each other.

[0043] Please refer to Figure 1 and Figure 2, this application provides a sample analyzer for analyzing a sample to be tested to obtain corresponding analysis results.

[0044] In some embodiments, the sample analyzer includes but is not limited to at least one of the following: biochemical analyzer, immunoassay analyzer, coagulation analyzer, urine analyzer.

[0045] Taking the immunoassay analyzer as an example for illustration, the immunoassay analyzer is a type of highly sensitive and specific analytical instrument, which is often used in clinical laboratories to detect various analysis indicators in blood, urine or other body fluids. Traditional immunoassay analyzers have various implementation principles, such as chemiluminescence method, electrochemiluminescence method, etc.

[0046] As Figure 1 shown, taking the chemiluminescence immunoassay analyzer as an example, its main working principle is as follows: when it is necessary to measure a certain component in the sample, the corresponding antibody / antigen can be coated on the magnetic beads to form a magnetic bead reagent, and a specific label is labeled on the antibody to form a labeled reagent (the reagent for measuring a certain analysis item generally has multiple components, such as the magnetic bead reagent component and the labeled reagent component here. Different components of the same item can be dispensed in different reagent containers or different cavities of the same reagent container). In the test process, the sample containing the analyte is first mixed with the magnetic bead reagent, the labeled reagent and other reagents to form a sample reagent reaction solution (abbreviated as reaction solution, also called mixture), and incubated under certain conditions to make the sample and the reagent react fully. At this time, the reaction solution contains the analyte and impurities. Usually, the analyte will be enriched on the surface of the magnetic particles of the added reagent (such as the surface of the magnetic beads). Then, through the washing and separation (Bound-free, generally abbreviated as B / F) technology, the impurities in the reaction solution (such as unbound labels and other reagents, samples) are removed; then a signal reagent (also called substrate) is added thereto, and the label on the analyte reacts with the signal reagent (or catalyzes the signal reagent) to emit light. By detecting the luminescence intensity of the analyte and using the calibration curve, the concentration of the analyte component in the sample can be calculated. The signal reagent can be one or more, such as luminescent substrate solution, pre-excitation solution, excitation solution and luminescence enhancement solution, etc.

[0047] As Figure 2 shown, the sample analyzer 100 includes a reaction solution preparation device 50, a reaction device 40, a detection device 60, a magnetic separation device 80 and a controller 70. Among them, the reaction solution preparation device 50 is used to fill the reaction container with the sample and the reagent to prepare a reaction solution. The reaction device 40 is provided with a reaction position for placing the reaction container and is used to provide an incubation place for the reaction solution in the reaction container.

[0048] The magnetic separation device 80 is used to perform magnetic separation cleaning (also known as magnetic separation) on the reaction solution in the reaction vessel, so as to extract the magnetic particles enriched with the analyte in the reaction solution, and clean the impurities attached to the surface of the magnetic particles, improve the purity of the analyte in the reaction solution, and further improve the accuracy of the sample detection result. For example, after the sample and the reagent react to form a reaction solution, the reaction device 40 incubates the reaction solution in the reaction vessel. After the incubation is completed, the reaction vessel is scheduled to the magnetic separation position on the magnetic separation device to perform magnetic separation on the reaction solution in the reaction vessel at the magnetic separation position.

[0049] The detection device 60 is used to detect the reaction solution to obtain the corresponding detection result. For example, after the sample and the reagent are mixed to form a reaction solution, they are incubated through the reaction device 40. After the incubation is completed, the magnetic separation device 80 performs magnetic separation cleaning on the incubated reaction solution, and then the detection device detects the reaction solution after magnetic separation cleaning to obtain the corresponding detection result. Another example is that after the sample and the reagent are mixed to form a reaction solution, they are incubated through the reaction device 40. After the incubation is completed, the magnetic separation device 80 performs magnetic separation cleaning on the incubated reaction solution. The reaction solution after magnetic separation cleaning is scheduled to the reaction device 40 again for incubation, and then the detection device detects the incubated reaction solution to obtain the corresponding detection result.

[0050] Optionally, the detection device 60 includes a photometric mechanism. The photometric mechanism is used to detect the luminescence intensity of the reaction solution, and calculate the concentration of the analyte in the sample through a calibration curve, etc. Optionally, the detection device 60 is separately arranged on the periphery of the reaction device 40. In another embodiment, the detection device 60 includes an electrical detection mechanism (such as an impedance measurement mechanism) or a detection mechanism based on other principles (such as an imaging measurement mechanism).

[0051] It can be understood that the reaction vessel includes but is not limited to reaction cups and reaction tubes. In the embodiments of the present application, the reaction vessel is taken as an example of a reaction cup for illustration.

[0052] In this application, the reaction solution is magnetically separated by the magnetic separation device 80, and the active ingredient in the reaction solution, that is, the analyte, can be extracted. At the same time, for the convenience of understanding the names of each stage of the sample and the reagent, the names of each stage of the sample and the reagent are described in detail here: the sample and the reagent in the reaction vessel are called the reaction solution after mixing, also called the mixture. The reaction device 40 can incubate the reaction solution in the reaction vessel to enable the sample and the reagent to react fully. At this time, the reaction solution in the reaction vessel after the full reaction includes the analyte and impurities. Among them, the reaction solution refers to the substance formed after the sample and the reagent are mixed, regardless of the ratio and concentration of the sample and the reagent, and is called the reaction solution here. The incubated reaction solution is presented in the reaction vessel in the form of the analyte and impurities. The impurities can be substances that have not reacted fully, by-products generated by side reactions, or other substances that affect the detection of the detection device 60, etc., or a combination of at least two of the above. The magnetic separation device 80 cleans the analyte and impurities in the reaction vessel to better remove the impurities in the reaction vessel and retain the analyte in the reaction vessel. The detection device 60 can detect the analyte in the reaction solution carried in the reaction vessel to obtain various parameters of the sample.

[0053] Optionally, after the magnetic separation is completed, a substrate can also be added to the reaction vessel after magnetic separation and cleaning. If a substrate is added to the reaction vessel after magnetic separation and cleaning, at this time, the inside of the reaction vessel is a mixture of the substrate and the analyte. Since the substrate does not change the properties of the analyte and only increases the luminescence value of the analyte, the reaction solution still has the analyte after the substrate and the analyte are mixed.

[0054] The detection device 60 detects the reaction solution containing the analyte to obtain the corresponding detection result. For example, the detection device 60 includes a photometric mechanism, and the photometric mechanism is used to detect the luminescence intensity of the reaction solution. Through the calibration curve, the concentration of the analyte (analyte) in the sample is calculated, etc.

[0055] As Figure 2 shown, in some embodiments, the reaction solution preparation device 50 includes a dispensing device 10, a sample supply device 20, and a reagent supply device 30. Among them, the sample supply device 20 is used to provide the sample to be tested, and the reagent supply device 30 is used to provide the reagent that reacts with the sample. The dispensing device 10 is used to dispense the sample provided by the sample supply device 20 and the reagent provided by the reagent supply device 30 into the reaction vessel so that the sample and the reagent are mixed to form a reaction solution.

[0056] Please refer to Figures 3 to 4, in some embodiments, the sample supply device 20 may include a sample dispensing module (SDM, Sample Delivery Module) and a front-end track; the sample supply device 20 may also be a sample tray, which includes a plurality of sample positions for placing samples such as sample tubes. By rotating its disc assembly, the sample tray can schedule the sample liquid placed in the sample tube to the corresponding position, for example, scheduling the sample tube carrying the sample liquid to the position where the dispensing device 10 sucks the sample. The dispensing device 10 is used to suck the sample liquid and discharge it into the reaction container to be loaded with the sample.

[0057] In some embodiments, the dispensing device 10 includes a sample dispensing device 10a. Among them, the sample dispensing device 10a is used to suck the sample supplied by the sample supply device 20 and transfer the sample to a preset position. For example, the sample supply device 20 carries a sample tube containing the sample to be tested. The sample dispensing device 10a sucks the sample to be tested from the sample tube carried by the sample supply device 20 and discharges the sample into the reaction container to be loaded with the sample.

[0058] Among them, the sample dispensing device 10a includes a sample needle 101, a first driving component 102, and a first pipetting driving part 103. The first driving component 102 is used to support the sample needle 101 and drive the sample needle 101 to move. For example, the sample needle 101 performs two-dimensional or three-dimensional movement in space through the two-dimensional or three-dimensional first driving component 102, so that the sample needle 101 can move to suck the sample carried by the sample supply device 20.

[0059] The first pipetting driving part 103 is used to suck the sample through the sample needle 101. For example, when the sample to be tested is a blood sample to be tested, the sample needle 101 moves to the sample tube containing the blood sample carried on the sample supply device 20 under the drive of the first driving component 102, and sucks the blood sample to be tested under the drive of the first pipetting driving part 103, and transports the blood sample to be tested into the reaction container at the reaction position in the reaction device 40. Thus, the blood sample to be tested sucked by the dispensing device 10 is mixed with the reagent provided by the reagent supply device 20 in the reaction container to prepare a reaction solution.

[0060] Such as Figure 4As shown, in some embodiments, the first driving assembly 102 includes a support frame 1021 fixed on a support rod 1022. The support rod 1022 can move vertically and rotate. Driven by the support rod 1022, the support frame 1021 realizes vertical movement and horizontal rotation. The sample needle 101 is arranged on the support frame 1021 and can reach the target position driven by the support frame 1021. Exemplarily, the first driving assembly 102 further includes a driver 1023 for driving the movement of the support rod 1022. For example, the driver is a stepper motor, but of course it is not limited thereto. Optionally, the sample needle 101 is detachably or fixedly connected to the first driving assembly 102.

[0061] In some embodiments, the dispensing device 10 further includes a reagent dispensing device 10b. The reagent supply device 30 includes a reagent carrying member 301 for carrying reagents. The reagent dispensing device 10b of the dispensing device 10 sucks the reagents carried by the reagent supply device 30 and provides them to the reaction device 40. Among them, the reagents include, but are not limited to, chromogenic reagents, diluents, substrate solutions, enzyme-labeled reagents, magnetic bead reagents, etc.

[0062] In some embodiments, the reagent carrying member 301 can be a reagent tray. The reagent tray is arranged as a disc-shaped assembly and has a plurality of positions for carrying reagent containers. The reagent carrying member 301 can rotate and drive the reagent containers carried by it to rotate, so as to rotate the reagent containers to specific positions, such as the reagent suction position where the reagent is sucked by the reagent dispensing device 10b. Among them, the number of the reagent carrying members 301 can be one or more.

[0063] In some embodiments, the reagent dispensing device 10b can include a reagent needle, a second driving assembly, and a second pipetting driving part. The reagent needle moves in two or three dimensions in space through the two-dimensional or three-dimensional second driving assembly, so that the reagent needle can move and cooperate with the second pipetting driving part to suck the reagents carried by the reagent carrying member 301, and move to the reaction container to be added with reagents and discharge the reagents into the reaction container.

[0064] In some embodiments, the second driving assembly and the first driving assembly 102 have the same structure, and / or the second pipetting driving part and the first pipetting driving part 103 have the same structure, which will not be elaborated here.

[0065] In some embodiments, the reagent dispensing device 10b does not add reagents by means of a reagent needle, but adds the reagents in the reagent tube to the reaction container through a dedicated pipeline. In such embodiments, there is only the sample needle 101 and no reagent needle.

[0066] It can be understood that, depending on the type of body fluid to be detected and the type of detection item, the sample and the reagent are added in different ways. For example, both the sample and the reagent can be added using the sample needle 101, or the sample is added using the sample needle 101 and the reagent is added using the reagent needle, or only the sample is added using the sample needle 101 and the reagent is added in other ways. That is to say, the sample dispensing device 10a of the dispensing device 10 is used for both transferring the sample and transferring the reagent; or the sample dispensing device 10a of the dispensing device 10 is used for sample transfer, and the reagent dispensing device 10b is used for reagent transfer; or the sample dispensing device 10a of the dispensing device 10 is used for sample transfer, and the reagent is connected to the reagent container carrying the reagent through a dedicated pipeline to add the reagent to the reaction container. Therefore, the sample needle 101 and / or the reagent needle are also called pipetting needles, that is, the pipetting needle includes at least any one of the sample needle 101 and the reagent needle.

[0067] In some embodiments, the reaction device 40 has a support portion 401, and at least one reaction position is provided on the support portion 401. The reaction position is used to place a reaction container, such as a reaction cup 4011. The reaction container is used to receive the sample supplied by the sample supply device 20 and the reagent supplied by the reagent supply device 30, and provides a reaction site for the sample and the reagent, so that the sample and the reagent are mixed to form a reaction solution. Optionally, the reaction device 40 is also used to incubate the reaction solution in the reaction container to make the reaction between the sample and the reagent more sufficient.

[0068] For example, the support portion 401 of the reaction device 40 can be a reaction disk, such as Figure 3 shown, which is arranged as a disk-shaped component and has one or more reaction positions for placing reaction containers. The reaction disk can incubate the reaction solution in the reaction container and can rotate to drive the reaction container placed in the reaction position to rotate, realizing the scheduling of the reaction containers in the reaction disk within a preset area.

[0069] It can be understood that the reaction position for the reaction cup can be provided not only on the reaction disk of the reaction device 40, but also independently of the reaction disk of the reaction device 40. The reaction position being provided independently of the reaction disk means that the setting of the reaction position does not interfere with the rotation of the reaction disk itself.

[0070] In some embodiments, as Figure 2 shown, the sample analyzer 100 further includes a scheduling device 90. The scheduling device 90 is used to perform the scheduling of the target object, where the target object includes but is not limited to the reaction container. For example, the scheduling device 90 grabs the reaction container and drives the reaction container to move in a two-dimensional or three-dimensional space. Or, after the reaction container is placed on the scheduling position provided on the scheduling device 90, the scheduling device 90 drives the reaction container placed on the scheduling position to move in a two-dimensional or three-dimensional space. The scheduling device 90 includes but is not limited to a gripper and a turntable.

[0071] For example, during the preparation of the reaction solution, the scheduling device 90 schedules the reaction vessel to be sampled to the sample position in the sample analyzer, so that the sample dispensing device 10a performs a sample addition operation on the reaction vessel placed at the sample position. After the sample addition operation is completed, the reaction vessel carrying the sample is scheduled to the reagent position, so that the reagent dispensing device 10b performs a reagent addition operation on the reaction vessel placed at the reagent position, thereby enabling the sample and the reagent to be mixed in the reaction vessel to form a reaction solution.

[0072] Alternatively, during the preparation of the reaction solution, the scheduling device 90 schedules the reaction vessel to the reagent position, so that the reagent dispensing device 10b performs a reagent addition operation on the reaction vessel placed at the reagent position. After the reagent addition operation is completed, the reaction vessel carrying the reagent is scheduled to the sample position, so that the sample dispensing device 10a performs a sample addition operation on the reaction vessel placed at the sample position, thereby enabling the sample and the reagent to be mixed in the reaction vessel to form a reaction solution.

[0073] Please refer to Figure 5 , in some embodiments, the magnetic separation device 80 includes a liquid injection mechanism 801, a magnetic adsorption mechanism 802, and a liquid suction mechanism 803. Among them, the liquid injection mechanism 801 is used to perform a cleaning liquid injection operation on the reaction vessel to clean the impurities attached to the surface of the magnetic particles; the magnetic adsorption mechanism 802 is used to perform a magnetic adsorption operation on the magnetic particles in the reaction solution in the reaction vessel; the liquid suction mechanism 803 is used to perform a liquid suction operation on the reaction vessel to suck the waste liquid generated during the magnetic separation process in the reaction vessel.

[0074] Such as Figure 5 shown, optionally, the magnetic separation device 80 further includes a mixing mechanism 804 for performing a mixing operation on the reaction solution in the reaction vessel. For example, after the liquid injection mechanism 801 completes the liquid injection operation on the reaction vessel, the mixing mechanism 804 performs a mixing operation on the reaction vessel, and the mixing operation includes but is not limited to mechanical mixing and ultrasonic mixing.

[0075] Please refer to Figure 6A , in some embodiments, the liquid suction mechanism 803 includes a liquid suction needle 8031, a first needle movement assembly 8032 for driving the movement of the liquid suction needle 8031, a liquid suction pipeline 8033 connected to the liquid suction needle 8031, and a first power assembly 8034 connected to the liquid suction needle 8031 through the liquid suction pipeline 8033 and used to provide liquid suction power.

[0076] Please refer to Figure 6B, in some embodiments, the liquid injection mechanism 801 includes a liquid injection needle 8011, a second needle movement assembly 8012 for driving the movement of the liquid injection needle 8011, a liquid injection pipeline 8013 connected to the liquid injection needle 8011, and a second power assembly 8014 connected to the liquid injection needle 8011 through the liquid injection pipeline 8013 and for providing liquid injection power.

[0077] In one embodiment, the liquid suction mechanism 803 includes a liquid suction needle 8031, a needle movement assembly for driving the movement of the liquid suction needle 8031, a liquid suction pipeline 8033 connected to the liquid suction needle 8031, and a first power assembly 8034 connected to the liquid suction needle 8031 through the liquid suction pipeline 8033 and for providing liquid suction power.

[0078] The liquid injection mechanism 801 includes a liquid injection needle 8011, a needle movement assembly for driving the movement of the liquid injection needle 8011, a liquid injection pipeline 8013 connected to the liquid injection needle 8011, and a second power assembly 8014 connected to the liquid injection needle 8011 through the liquid injection pipeline 8013 and for providing liquid injection power. Among them, the liquid suction needle 8031 and the liquid injection needle 8011 are integrally or separately provided and fixedly connected, and are driven by a common needle movement assembly (for example, driven by the first needle movement assembly or the second needle movement assembly) to move in a two-dimensional or three-dimensional space.

[0079] As Figure 6C shown, for example, the way that the liquid suction needle 8031 and the liquid injection needle 8011 are integrally provided can be that the sample analyzer 100 includes a liquid suction and injection component 800, and the liquid suction and injection component 800 is formed with a liquid suction channel 800a for sucking liquid from the reaction vessel and a liquid injection channel 800b for injecting liquid into the reaction vessel. When the liquid suction and injection component 800 performs liquid suction on the reaction vessel through the liquid suction channel 800a, the liquid suction and injection component 800 can be used as a liquid suction needle; when the liquid suction and injection component 800 performs liquid injection on the reaction vessel through the liquid injection channel 800b, the liquid suction and injection component 800 can be used as a liquid injection needle; when the liquid suction and injection component 800 performs liquid suction on the reaction vessel through the liquid suction channel 800a and performs liquid injection on the reaction vessel through the liquid injection channel 800b, the liquid suction and injection component 800 can be used as both a liquid suction needle and a liquid injection needle at the same time.

[0080] It can be understood that the power assemblies for providing power for the liquid suction operation and the liquid discharge operation include but are not limited to pumps and syringes.

[0081] In some embodiments, the magnetic separation device 80 further includes a substrate injection mechanism 805 for adding a substrate to the reaction vessel that has completed magnetic separation cleaning. Exemplarily, after the reaction vessel carrying the reaction solution formed by mixing the sample and the reagent is transferred to the reaction device 40, the reaction device 40 incubates the sample and the reagent in the reaction vessel. The incubated reaction vessel is transferred to the magnetic separation device 80 for magnetic separation cleaning. The reaction vessel after the magnetic separation cleaning is injected with the substrate through the substrate injection mechanism 805. The reaction vessel after the substrate injection is transferred to the reaction device 40 for incubation. The incubated reaction vessel is then transferred to the corresponding detection position so that the detection device 60 can detect the reaction solution in the reaction vessel (e.g., perform luminescence detection) to obtain the corresponding parameters of the sample. Among them, the transfer of the reaction vessel can be carried out by the scheduling device 90 in the sample analyzer 100.

[0082] The controller 70 is communicatively connected to the reaction solution preparation device 50, the reaction device 40, the magnetic separation device 80, and the detection device 60 to control at least one of the reaction solution preparation device 50, the reaction device 40, the magnetic separation device 80, and the detection device 60 to complete a preset operation. For example, control the reaction solution preparation device 50 to complete the preparation of the reaction solution, or control the magnetic separation device 80 to complete the magnetic separation cleaning of the reaction solution.

[0083] It can be understood that the controller 70 can be one or more, and can be disposed in at least any one of the reaction solution preparation device 50, the reaction device 40, the magnetic separation device 80, and the detection device 60, or can be independently disposed, which is not limited herein.

[0084] In some embodiments, the controller 70 at least includes a processor 701, a memory 702, a communication interface (not shown in the figure), and an I / O interface (not shown in the figure). The processor 701, the memory 702, the communication interface, and the I / O interface communicate through a bus. The processor 701 can be a central processing unit (CPU), and this processor can also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Among them, the general-purpose processor can be a microprocessor or this processor can also be any conventional processor, etc.

[0085] The memory 702 stores various computer programs for the processor 701 to execute, such as an operating system and application programs, as well as data required for executing the computer programs. During the analysis of the sample to be tested, any data that needs to be locally stored can be stored in the memory 702. The I / O interface includes, but is not limited to, serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces composed of D / A converters and converters, etc. An input component is connected to the I / O interface. The user can directly input data to the controller 70 using the input component, and the input component includes, but is not limited to, a keyboard, a mouse, a touch screen, or control buttons. The display component can be communicatively connected to the controller 70 through the I / O interface for relevant information prompting. The communication interface can be an interface of any currently known communication protocol. The communication interface communicates with the outside world through a network. The controller 70 can transmit data to any component connected through the network in a preset communication protocol through the communication interface.

[0086] In some embodiments, communicatively connected to the magnetic separation device 80, and during the magnetic separation cleaning process of the reaction solution in the reaction vessel by the magnetic separation device 80, the controller 70 is at least used for:

[0087] Controlling the liquid injection mechanism 801 to perform a liquid injection operation on the reaction vessel, controlling the magnetic adsorption mechanism 802 to perform a magnetic adsorption operation on the magnetic particles in the reaction solution in the reaction vessel, and controlling the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the reaction vessel;

[0088] Wherein, the liquid suction operation at least includes: controlling the first needle moving component 8032 to drive the liquid suction needle 8031 to move below the liquid level in the reaction vessel, and controlling the first power component 8034 to drive the liquid suction needle 8031 to perform a liquid suction action;

[0089] After the continuous liquid suction time of the liquid suction action reaches a preset time, controlling the first needle moving component 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel, and after the liquid suction needle 8031 moves above the liquid level of the liquid in the reaction vessel, controlling the first power component 8034 to continuously drive the liquid suction needle 8031 to perform a liquid suction action.

[0090] Exemplarily, after the sample and the reagent are prepared into a reaction solution, the reaction solution contains the analyte and impurities. The magnetic separation device 80 is used to perform magnetic separation on the reaction solution in the reaction vessel. That is, by performing at least a liquid injection operation, a magnetic adsorption operation, and a liquid suction operation on the reaction solution containing the analyte and impurities, the analyte and impurities can be better separated, so as to effectively remove the impurities in the reaction solution and retain the effective analyte in the reaction solution.

[0091] Specifically, the sample analyzer 100 is provided with operation positions. During the magnetic separation process of the reaction liquid in the reaction vessel by the magnetic separation device 80, the reaction vessel is scheduled to pass through one or more operation positions, so that the liquid injection mechanism 801, the magnetic adsorption mechanism 802, and the liquid suction mechanism 803 of the magnetic separation device 80 perform corresponding operations at the corresponding operation positions. Among them, the corresponding operations include the liquid injection operation performed by the liquid injection mechanism 801 on the reaction vessel located at the corresponding operation position, the liquid suction operation performed by the liquid suction mechanism 803 on the reaction vessel located at the corresponding operation position, and the magnetic adsorption operation performed by the magnetic adsorption mechanism 802 on the reaction vessel located at the corresponding operation position. The execution sequence and the operation positions of the liquid injection operation, the liquid suction operation, and the magnetic adsorption operation are not limited herein.

[0092] That is, the liquid injection operation, the magnetic adsorption operation, and the liquid suction operation can be allocated to one operation position for simultaneous execution, or the liquid injection operation, the magnetic adsorption operation, and the liquid suction operation can be allocated to one operation position for time-sharing execution according to a preset execution sequence. It can also be that the liquid injection operation, the magnetic adsorption operation, and the liquid suction operation are allocated to at least two different operation positions for simultaneous execution. Moreover, the liquid injection operation, the magnetic adsorption operation, and the liquid suction operation can be allocated to at least two different operation positions and are time-sharing executed according to a preset execution sequence.

[0093] For example, taking the operation positions including at least a first cleaning position and a second cleaning position as an example, during the magnetic separation process of the reaction liquid in the reaction vessel by the magnetic separation device 80, after the reaction vessel is scheduled to the first cleaning position, the liquid suction mechanism 803 performs a liquid suction operation on the reaction vessel located at the first cleaning position to pump out the waste liquid in the reaction vessel. After the liquid suction operation is completed, the liquid injection mechanism 801 performs a liquid injection operation on the reaction vessel located at the first cleaning position. After the liquid injection operation is completed, the reaction vessel is scheduled from the first cleaning position to the second cleaning position. After the reaction vessel is scheduled to the second cleaning position, the liquid suction mechanism 803 performs a liquid suction operation on the reaction vessel located at the second cleaning position to pump out the waste liquid in the reaction vessel.

[0094] Among them, at least before the liquid suction mechanism 803 performs a liquid suction operation on the reaction vessel located at the corresponding cleaning position (the first cleaning position and / or the second cleaning position), or during the liquid suction operation on the reaction vessel located at the corresponding cleaning position, the magnetic adsorption mechanism 802 performs a magnetic adsorption operation on the reaction vessel located at the corresponding cleaning position, so as to agglomerate magnetic particles on the vessel wall of the reaction vessel through magnetic adsorption, so as to reduce the probability of effective analytes being pumped away with the waste liquid during the waste liquid suction process of the liquid suction mechanism 803, and retain the effective analytes to a greater extent. Alternatively, the operation position further includes a magnetic adsorption position. Before the reaction vessel is scheduled to the corresponding cleaning position (such as the first cleaning position and / or the second cleaning position), the reaction vessel is scheduled to the magnetic adsorption position, so that the magnetic adsorption mechanism 802 performs a magnetic adsorption operation on the reaction vessel located at the magnetic adsorption position.

[0095] Moreover, during the magnetic separation process, the liquid suction operation performed by the controller 70 controlling the liquid suction mechanism 803 at least includes: controlling the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move below the liquid level in the reaction vessel, and controlling the first power assembly 8034 to drive the liquid suction needle 8031 to perform a liquid suction action, such as Figure 7A As shown, the liquid suction needle 8031 moves below the liquid level of the reaction vessel under the drive of the first needle moving assembly 8032, and the tip of the liquid suction needle 8031 is at a distance D from the bottom of the reaction vessel.

[0096] Among them, the liquid suction action can be performed by the first power assembly 8034 driving the liquid suction needle 8031 before the liquid suction needle 8031 enters below the liquid level of the reaction vessel. It can also be performed by the first power assembly 8034 driving the liquid suction needle 8031 after the liquid suction needle 8031 enters below the liquid level of the reaction vessel. And whether the liquid suction needle 8031 enters the liquid level can be determined by the distance that the first needle moving assembly 8032 drives the liquid suction needle 8031 to move, or can be determined by the liquid level detection device set by the sample analyzer, which is not limited here.

[0097] After the continuous liquid suction time of the liquid suction action reaches the preset time, control the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel. After the liquid suction needle 8031 moves above the liquid level of the liquid in the reaction vessel, the first power assembly 8034 continuously drives the liquid suction needle 8031 to perform a liquid suction action. Such as Figure 7BAs shown, after the duration of the liquid suction operation performed by the liquid suction needle 8031 reaches the preset time, the liquid volume in the reaction vessel will decrease. If the liquid suction needle 8031 continues to perform the liquid suction operation, the probability of magnetic loss caused by sucking magnetic particles (such as magnetic beads) attached with the active substance will increase. Therefore, by lifting the liquid suction needle 8031 above the liquid level and keeping the tip of the liquid suction needle 8031 at a distance D1 from the bottom of the reaction vessel, where D1 > D, the liquid suction needle 8031 cannot suck the remaining liquid in the reaction vessel, effectively reducing the magnetic loss during the liquid suction process.

[0098] In this embodiment, based on the fact that the liquid suction operation performed by the liquid suction mechanism 803 on the liquid in the reaction vessel during the magnetic separation process is one of the important reasons for magnetic loss. In this embodiment, when the liquid suction mechanism 803 performs the liquid suction operation on the liquid in the reaction vessel, after controlling the liquid suction needle 8031 to perform the liquid suction operation under the liquid level in the reaction vessel for a preset time, then the liquid suction needle 8031 is lifted above the liquid level, avoiding the liquid suction needle 8031 sucking the magnetic particles in the reaction vessel under the liquid level for a long time and causing magnetic loss, thereby effectively reducing the magnetic loss of the sample analyzer during the magnetic separation process, retaining the active substance attached to the magnetic beads to a large extent, and improving the accuracy of the detection results.

[0099] At the same time, after the liquid suction needle 8031 moves above the liquid level in the reaction vessel, since the liquid suction needle 8031 continues to perform the liquid suction operation, the liquid in the liquid suction needle 8031, or the liquid in the liquid suction needle 8031 and the liquid suction pipeline 8033 can be pumped out, enabling the liquid suction mechanism 803 to accurately suck the corresponding amount of liquid during the next liquid suction operation, achieving accurate liquid suction and reducing the overflow probability of the reaction vessel during the liquid injection process.

[0100] That is, during the magnetic separation process, if there is un-pumped liquid in the liquid suction needle 8031 and the liquid suction pipeline 8033, it will cause the situation that the liquid suction amount of the liquid in the reaction vessel by the liquid suction mechanism 803 is less than the preset liquid suction amount during the liquid suction operation on the reaction vessel, that is, after the liquid suction mechanism 803 finishes the liquid suction operation, there is excessive remaining liquid in the reaction vessel, and then when the liquid injection mechanism 801 performs the liquid injection operation on the reaction vessel, the liquid volume in the reaction vessel may exceed the volume of the reaction vessel, resulting in liquid overflow.

[0101] In some embodiments, during the process of controlling the first power component 8034 to drive the liquid suction needle 8031 to perform the liquid suction operation, the controller 70 performs:

[0102] Control the liquid suction needle 8031 to move under the liquid level in the reaction vessel when the first power component 8034 is in the closed state;

[0103] After the liquid suction needle 8031 moves to the first position below the liquid level in the reaction vessel, the first power assembly 8034 is controlled to start 8034 to drive the liquid suction needle 8031 to perform a liquid suction operation.

[0104] Optionally, the controller 70 is further configured to: adjust the continuous liquid suction time corresponding to the liquid suction operation performed by the liquid suction needle 8031 below the liquid level in the reaction vessel by controlling the starting driving time of the first power assembly 8034 for the liquid suction needle 8031.

[0105] Exemplarily, for the liquid suction operation, after the liquid suction needle 8031 moves to the first position below the liquid level in the reaction vessel, the first power assembly 8034 starts, so as to drive the liquid suction needle 8031 to suck liquid, which is convenient for controlling the starting time of the first power assembly 8034 to regulate the continuous liquid suction time of the liquid suction needle 8031 performing the liquid suction operation below the liquid level, thereby realizing accurate liquid suction of the liquid suction needle 8031 below the liquid level.

[0106] In some embodiments, the controller 70 is further configured to: determine the continuous liquid suction time corresponding to controlling the first power assembly 8034 to drive the liquid suction needle 9031 to perform a liquid suction operation according to the item parameters of the current detection item of the sample analyzer 100.

[0107] Alternatively, determine the continuous liquid suction time corresponding to controlling the first power assembly 8034 to drive the liquid suction needle 9031 to perform a liquid suction operation below the liquid level of the liquid in the reaction vessel according to the item parameters of the current detection item of the sample analyzer 100.

[0108] Exemplarily, there are multiple detection items performed by the sample analyzer 100 on the sample to be tested, and corresponding item parameters are adapted to different detection items. The current detection item performed by the sample analyzer 100 is determined according to the item parameters.

[0109] During the magnetic separation process, in order to improve the magnetic separation effect, the continuous liquid suction time corresponding to the liquid suction operation of the liquid suction needle 8031 above and / or below the liquid level is different for different detection items. Therefore, the continuous liquid suction time corresponding to controlling the first power assembly 8034 to drive the liquid suction needle 8031 to perform a liquid suction operation above and / or below the liquid level of the liquid in the reaction vessel is determined through the item parameters of the current detection item, so as to realize accurate liquid suction of the liquid in the reaction vessel, and further improve the magnetic separation effect.

[0110] In some embodiments, during the magnetic separation cleaning process performed by the magnetic separation device 80, the controller 70 is further configured to:

[0111] Control the liquid injection mechanism 801 to perform a liquid injection operation with a first liquid injection volume into the reaction vessel, and after the liquid injection operation with the first liquid injection volume is completed, control the liquid suction mechanism 803 to perform a liquid suction operation with a first liquid suction volume on the liquid in the reaction vessel;

[0112] After the liquid suction operation with the first liquid suction volume is completed, control the liquid injection mechanism 801 to perform a liquid injection operation with a second liquid injection volume into the reaction vessel, and after the liquid injection operation with the second liquid injection volume is completed, control the liquid suction mechanism 803 to perform a liquid suction operation with a second liquid suction volume on the liquid in the reaction vessel;

[0113] Wherein, when the second liquid injection volume is greater than the first liquid injection volume, the second liquid suction volume is greater than the first liquid suction volume.

[0114] Exemplarily, during the magnetic separation cleaning process of the magnetic separation device 80, the liquid injection mechanism 801 and the liquid suction mechanism 803 need to perform at least two injection-suction cycles. One injection-suction cycle includes one liquid injection operation and one liquid suction operation. The liquid injection volume of the liquid injection operation and / or the liquid suction volume corresponding to the liquid suction operation in different injection-suction cycles can be the same or different. It only needs to satisfy that the greater the liquid injection volume corresponding to the liquid injection operation in the current injection-suction cycle, the greater the liquid suction volume corresponding to the liquid suction operation in the current injection-suction cycle, so as to reduce the probability of the reaction vessel overflowing.

[0115] In some embodiments, the controller 70 is further configured to: control the magnetic separation device 80 to perform at least two-stage magnetic separation cleaning on the reaction liquid in the reaction vessel, and in different-stage magnetic separation cleaning, the liquid injection volume corresponding to the liquid injection operation performed by the liquid injection mechanism 801 into the reaction vessel increases sequentially following the stage number corresponding to the magnetic separation cleaning.

[0116] Exemplarily, the magnetic separation device 80 performs at least two-stage magnetic separation cleaning on the reaction liquid in the reaction vessel. Each stage of magnetic separation cleaning at least includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, and a liquid suction sub-cycle. Among them, the controller 70 controls the liquid injection mechanism 801 to perform a liquid injection operation into the reaction vessel during the liquid injection sub-cycle; controls the magnetic adsorption mechanism 802 to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel during the magnetic adsorption sub-cycle; and controls the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the reaction vessel during the liquid suction sub-cycle.

[0117] Taking two-stage magnetic separation cleaning as an example, in the first-stage magnetic separation cleaning, the liquid injection volume corresponding to the liquid injection operation performed by the liquid injection mechanism 801 is Q1. After the first-stage magnetic separation cleaning is completed, the second-stage magnetic separation cleaning is performed, and in the second-stage magnetic separation cleaning, the liquid injection volume corresponding to the liquid injection operation performed by the liquid injection mechanism 801 is Q2, and Q2 is greater than Q1. By increasing the liquid injection volume of the liquid injection operation in different-stage magnetic separations, the effect of magnetic separation cleaning can be effectively improved.

[0118] In some embodiments, during the magnetic separation cleaning process performed by the magnetic separation device 80, the controller 70 is further configured to:

[0119] After the reaction vessel is scheduled to the cleaning position, control the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the reaction vessel; after the liquid suction operation is completed, control the liquid suction mechanism 803 to perform liquid suction on the same reaction vessel located at the same cleaning position.

[0120] Please refer to Figure 8 , for example, the magnetic separation device 80 performs at least one - order magnetic separation cleaning on the reaction vessel, and in at least the first - order magnetic separation cleaning, the liquid suction mechanism 803 performs liquid suction on the reaction vessel at the same operation position (such as the cleaning position) twice, and the liquid suction operations corresponding to the first liquid suction and the second liquid suction may be the same or different.

[0121] Taking the case where the liquid suction operations corresponding to the first liquid suction and the second liquid suction are different as an example, the liquid suction operation corresponding to the first liquid suction may be: the controller 70 controls the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move below the liquid level in the reaction vessel, and controls the first power assembly 8034 to drive the liquid suction needle 8031 to perform a liquid suction action; after the continuous liquid suction time of the liquid suction action reaches a preset time, control the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel; and after the liquid suction needle 8031 moves above the liquid level of the liquid in the reaction vessel, the first power assembly 8034 continuously drives the liquid suction needle 8031 to perform a liquid suction action.

[0122] The liquid suction operation corresponding to the second liquid suction may be: after the first liquid suction is completed, the controller 70 controls the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move below the liquid level in the reaction vessel, and controls the first power assembly 8034 to drive the liquid suction needle 8031 to perform a liquid suction action; after the continuous liquid suction time of the liquid suction action reaches a preset duration, control the first power assembly 8034 to stop driving the liquid suction needle 8031 to perform a liquid suction action, and then control the first needle moving assembly 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel.

[0123] Optionally, between the first liquid suction and the second liquid suction performed by the liquid suction mechanism 803, the liquid injection mechanism 801 does not perform a liquid injection operation on the reaction vessel located at this operation position, so as to improve the liquid suction effect of the liquid suction mechanism 803 on the reaction vessel.

[0124] Please refer to Figure 9A , in some embodiments, during the magnetic separation cleaning process performed by the magnetic separation device 80 on the reaction liquid in the reaction vessel, the controller 70 is further configured to:

[0125] After the reaction vessel is scheduled to the cleaning position, control the first needle moving component 8032 to drive the liquid suction needle to move below the liquid level in the reaction vessel at the cleaning position, and control the first power component 8034 to drive the liquid suction needle to perform the liquid suction action; after the continuous liquid suction time of the liquid suction action reaches the preset time, control the first needle moving component 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel, and after the liquid suction needle 8031 moves above the liquid level of the liquid in the reaction vessel, the first power component 8034 continuously drives the liquid suction needle 8031 to perform the liquid suction action.

[0126] After the continuous liquid suction time of the liquid suction action performed by the liquid suction needle 8031 above the liquid level of the liquid in the reaction vessel reaches the first time, control the liquid injection mechanism 801 to move into the same reaction vessel at the same cleaning position and perform the liquid injection operation on the reaction vessel, that is, the liquid injection needle 8011 moves into the reaction vessel at the same cleaning position and injects liquid into the reaction vessel.

[0127] Please refer to Figure 9B , in some embodiments, during the magnetic separation cleaning process of the reaction liquid in the reaction vessel by the magnetic separation device 80, the controller 70 is further configured to:

[0128] After the reaction vessel is scheduled to the cleaning position, control the first needle moving component 8032 to drive the liquid suction needle to move below the liquid level in the reaction vessel at the cleaning position, and control the first power component 8034 to drive the liquid suction needle to perform the liquid suction action; after the continuous liquid suction time of the liquid suction action reaches the preset time, control the first needle moving component 8032 to drive the liquid suction needle 8031 to move above the liquid level of the liquid in the reaction vessel, and after the liquid suction needle 8031 moves above the liquid level of the liquid in the reaction vessel, the first power component 8034 continuously drives the liquid suction needle 8031 to perform the liquid suction action.

[0129] After the continuous liquid suction time of the liquid suction action performed by the liquid suction needle 8031 above the liquid level of the liquid in the reaction vessel reaches the first time, control the liquid injection mechanism 801 to move into the same reaction vessel at the first cleaning position and perform the liquid injection operation on the reaction vessel, that is, the liquid injection needle 8011 moves into the reaction vessel at the first cleaning position and injects liquid into the reaction vessel.

[0130] After the liquid injection mechanism 801 completes the liquid injection operation, control the scheduling device 90 to schedule the reaction vessel to the next operation position (such as, the second cleaning position), and control the liquid suction mechanism 803 to perform the liquid suction operation on the reaction vessel at the second cleaning position.

[0131] Optionally, a liquid suction mechanism 803 and a liquid injection mechanism 801 are correspondingly arranged for each cleaning position. The liquid suction mechanism 803 includes a liquid suction needle 8031, a needle moving assembly for driving the movement of the liquid suction needle 8031, a liquid suction pipeline 8033 connected to the liquid suction needle 8031, and a first power assembly 8034 connected to the liquid suction needle 8031 through the liquid suction pipeline 8033 and used for providing liquid suction power. The liquid injection mechanism 801 includes a liquid injection needle 8011, a second needle moving assembly 8012 for driving the movement of the liquid injection needle 8011, a liquid injection pipeline 8013 connected to the liquid injection needle 8011, and a second power assembly 8014 connected to the liquid injection needle 8011 through the liquid injection pipeline 8013 and used for providing liquid injection power.

[0132] Optionally, a liquid suction and injection component 800 is correspondingly arranged for each cleaning position. The liquid suction and injection component 800 is formed with a liquid suction channel 800a for sucking liquid from the reaction vessel and a liquid injection channel 800b for injecting liquid into the reaction vessel. When the liquid suction and injection component 800 performs liquid suction on the reaction vessel through the liquid suction channel 800a, the liquid suction and injection component 800 can be used as a liquid suction needle; when the liquid suction and injection component 800 performs liquid injection on the reaction vessel through the liquid injection channel 800b, the liquid suction and injection component 800 can be used as a liquid injection needle; when the liquid suction and injection component 800 performs liquid suction on the reaction vessel through the liquid suction channel 800a and performs liquid injection on the reaction vessel through the liquid injection channel 800b, the liquid suction and injection component 800 can be used as both a liquid suction needle and a liquid injection needle at the same time.

[0133] Please refer to Figure 10 , in some embodiments, the operation of the sample analyzer 100 includes a first cleaning position and a second cleaning position. The magnetic separation device 80 performs at least two-stage magnetic separation cleaning on the reaction liquid in the reaction vessel. At least one stage of magnetic separation cleaning has at least two liquid suction sub-cycles, that is, at least one stage of magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, a first liquid suction sub-cycle, and a second liquid suction sub-cycle.

[0134] The controller 70 is further configured to: control the liquid injection mechanism 801 to perform a liquid injection operation on the reaction vessel located at the liquid injection position during the liquid injection sub-cycle; control the magnetic adsorption mechanism 802 to perform a magnetic adsorption operation on the magnetic particulate matter in the reaction liquid in the reaction vessel located at the magnetic adsorption position during the magnetic adsorption sub-cycle; control the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the reaction vessel located at the first cleaning position during the first liquid suction sub-cycle; and control the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the same reaction vessel that has completed liquid suction at the first cleaning position and has been scheduled to the second cleaning position during the second liquid suction sub-cycle. During the period after the liquid suction mechanism 803 completes the liquid suction operation at the first cleaning position and before it completes the liquid suction operation at the second cleaning position, the liquid injection mechanism 801 does not perform a liquid injection operation on this reaction vessel.

[0135] That is, after the liquid suction mechanism 803 performs a liquid suction operation on the reaction vessel at the first cleaning position, the reaction vessel at the first cleaning position is scheduled to the second cleaning position, and the liquid suction mechanism 803 continuously performs a liquid suction operation on the reaction vessel at the second cleaning position.

[0136] Optionally, to improve the liquid suction effect of the liquid suction mechanism 803 at the second cleaning position, when the liquid suction mechanism 803 performs a liquid suction operation at the first cleaning position, the distance between the liquid suction needle and the bottom of the reaction vessel is a first distance; when the liquid suction mechanism 803 performs a liquid suction operation at the second cleaning position, the distance between the liquid suction needle and the bottom of the reaction vessel is a second distance, and the second distance is less than or equal to the first distance.

[0137] In some embodiments, the magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, and a liquid suction sub-cycle; the controller 70 is further configured to: control the liquid injection mechanism 801 to perform a liquid injection operation on the reaction vessel during the liquid injection sub-cycle, and control the magnetic adsorption mechanism 802 to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel during the magnetic adsorption sub-cycle, and control the liquid suction mechanism 803 to perform a liquid suction operation on the liquid in the reaction vessel during the liquid suction sub-cycle;

[0138] Wherein, the number of liquid suction sub-cycles is N, N is a positive integer, N≥2, and in the Nth liquid suction sub-cycle, the first power assembly 8034 drives the liquid suction needle 8031 to perform a liquid suction action below the liquid level of the reaction vessel for the longest continuous liquid suction time.

[0139] Exemplarily, the magnetic separation device 80 performs at least first-order magnetic separation cleaning on the test sample, and any order of magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, and a liquid suction sub-cycle, and the number of liquid suction sub-cycles is greater than or equal to 2. When there are at least two liquid suction sub-cycles in the magnetic separation cleaning, to improve the liquid suction effect of the liquid suction operation, the last liquid suction sub-cycle performs a liquid suction action below the liquid level of the reaction vessel for the longest continuous liquid suction time.

[0140] Hereinafter, in combination with the working principle of the sample analyzer 100, the liquid suction control method provided by the embodiments of the present application will be described.

[0141] The embodiments of the present application further provide a liquid suction control method, which is applied to the aforementioned sample analyzer 100. The sample analyzer 100 is provided with a reaction liquid preparation device and a magnetic separation device. The method includes:

[0142] Controlling the reaction liquid preparation device to add a sample and a reagent to the reaction vessel to prepare a reaction liquid;

[0143] Control the magnetic separation device to perform magnetic separation cleaning on the reaction vessel carrying the reaction liquid. The magnetic separation cleaning includes: controlling the liquid injection mechanism of the magnetic separation device to perform a liquid injection operation on the reaction vessel filled with the reaction liquid, controlling the magnetic adsorption mechanism of the magnetic separation device to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel, and controlling the liquid suction mechanism of the magnetic separation device to perform a liquid suction operation on the liquid in the reaction vessel;

[0144] Wherein, the liquid suction operation at least includes: controlling the first needle moving component of the liquid suction mechanism to drive the liquid suction needle of the liquid suction mechanism to move below the liquid level in the reaction vessel, and controlling the first power component of the liquid suction mechanism to drive the liquid suction needle to perform a liquid suction action;

[0145] After the continuous liquid suction time of the liquid suction action reaches a preset time, control the first needle moving component to drive the liquid suction needle to move above the liquid level of the liquid in the reaction vessel; and after the liquid suction needle moves above the liquid level of the liquid in the reaction vessel, control the first power component to continuously drive the liquid suction needle to perform the liquid suction action

[0146] In some embodiments, controlling the first power component to drive the liquid suction needle to perform a liquid suction action includes:

[0147] Controlling the liquid suction needle to move below the liquid level in the reaction vessel when the first power component is in a closed state;

[0148] After the liquid suction needle moves to the first position below the liquid level in the reaction vessel, control the first power component to start to drive the liquid suction needle to perform the liquid suction action.

[0149] In some embodiments, the method further includes: adjusting the continuous liquid suction time corresponding to the liquid suction action performed by the liquid suction needle below the liquid level of the liquid in the reaction vessel by controlling the starting driving time of the first power component for the liquid suction needle.

[0150] In some embodiments, the method further includes: determining the continuous liquid suction time corresponding to the liquid suction action performed by the liquid suction needle below the liquid level of the liquid in the reaction vessel by controlling the first power component according to the item parameters of the current detection item of the sample analyzer.

[0151] In some embodiments, the method further includes: controlling the liquid injection mechanism to perform the liquid injection operation with a first liquid injection volume on the reaction vessel, and after the liquid injection operation with the first liquid injection volume is completed, controlling the liquid suction mechanism to perform the liquid suction operation with a first liquid suction volume on the liquid in the reaction vessel;

[0152] After the liquid suction operation with the first liquid suction volume is completed, control the liquid injection mechanism to perform the liquid injection operation with the second liquid injection volume into the reaction vessel, and after the liquid injection operation with the second liquid injection volume is completed, control the liquid suction mechanism to perform the liquid suction operation with the second liquid suction volume on the liquid in the reaction vessel;

[0153] Wherein, when the second liquid injection volume is greater than the first liquid injection volume, the second liquid suction volume is greater than the first liquid suction volume.

[0154] In some embodiments, the method further includes: controlling the magnetic separation device to perform at least two stages of magnetic separation cleaning on the reaction liquid in the reaction vessel, and in different stages of magnetic separation cleaning, the liquid injection volume corresponding to the liquid injection operation performed by the liquid injection mechanism into the reaction vessel increases sequentially following the stage number corresponding to the magnetic separation cleaning.

[0155] In some embodiments, the method further includes: when the reaction vessel is scheduled to the cleaning position, controlling the liquid suction mechanism to perform the liquid suction operation on the liquid in the reaction vessel; after the liquid suction operation is completed, controlling the liquid suction mechanism to perform liquid suction on the same reaction vessel located at the same cleaning position.

[0156] In some embodiments, the method further includes: when the reaction vessel is scheduled to the cleaning position, controlling the first needle moving assembly to drive the liquid suction needle to move below the liquid level in the reaction vessel at the cleaning position, and controlling the first power assembly to drive the liquid suction needle to perform the liquid suction action; after the continuous liquid suction time of the liquid suction action reaches the preset time, controlling the first needle moving assembly to drive the liquid suction needle to move above the liquid level of the liquid in the reaction vessel, and after the liquid suction needle moves above the liquid level of the liquid in the reaction vessel, the first power assembly continuously drives the liquid suction needle to perform the liquid suction action;

[0157] When the continuous liquid suction time of the liquid suction action performed by the liquid suction needle above the liquid level of the liquid in the reaction vessel reaches the first time, control the liquid injection mechanism to move into the same reaction vessel located at the same cleaning position and perform the liquid injection operation on the reaction vessel.

[0158] In some embodiments, one liquid suction mechanism and one liquid injection mechanism are correspondingly arranged at each cleaning position, wherein the liquid injection mechanism includes a liquid injection needle, a liquid injection pipeline connected to the liquid injection needle, a second needle moving assembly for driving the liquid injection needle to move, and a second power assembly connected to the liquid injection needle through the liquid injection pipeline and used for providing liquid injection power;

[0159] Alternatively, each of the cleaning positions is correspondingly provided with a suction and injection component, and the suction and injection component is formed with a liquid suction channel for sucking liquid from the reaction vessel and a liquid injection channel for injecting liquid into the reaction vessel.

[0160] In some embodiments, the sample analyzer is further provided with a first cleaning position and a second cleaning position, and the magnetic separation device performs at least two-stage magnetic separation cleaning on the reaction liquid in the reaction vessel. At least one stage of the magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, a first liquid suction sub-cycle, and a second liquid suction sub-cycle;

[0161] The method further includes: controlling the liquid injection mechanism to perform the liquid injection operation on the reaction vessel during the liquid injection sub-cycle; controlling the magnetic adsorption mechanism to perform the magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel during the magnetic adsorption sub-cycle; controlling the liquid suction mechanism to perform the liquid suction operation on the liquid in the reaction vessel located at the first cleaning position during the first liquid suction sub-cycle; and controlling the liquid suction mechanism to perform the liquid suction operation on the liquid in the same reaction vessel that has completed liquid suction at the first cleaning position and has been scheduled to the second cleaning position during the second liquid suction sub-cycle.

[0162] In some embodiments, when the liquid suction mechanism performs the liquid suction operation at the first cleaning position, the distance between the liquid suction needle and the bottom of the reaction vessel is a first distance;

[0163] When the liquid suction mechanism performs the liquid suction operation at the second cleaning position, the distance between the liquid suction needle and the bottom of the reaction vessel is a second distance, and the second distance is less than or equal to the first distance.

[0164] In some embodiments, the magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, and a liquid suction sub-cycle; the method further includes: controlling the liquid injection mechanism to perform the liquid injection operation on the reaction vessel during the liquid injection sub-cycle, controlling the magnetic adsorption mechanism to perform the magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction vessel during the magnetic adsorption sub-cycle, and controlling the liquid suction mechanism to perform the liquid suction operation on the liquid in the reaction vessel during the liquid suction sub-cycle;

[0165] Wherein, the number of the liquid suction sub-cycles is N, N is a positive integer, N≥2, and in the Nth liquid suction sub-cycle, the first power component drives the liquid suction needle to perform the liquid suction action below the liquid level of the reaction vessel for the longest continuous liquid suction time.

[0166] It should be noted that those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working process of the above-described liquid suction control method can refer to the corresponding working process of the foregoing sample analyzer, and will not be elaborated herein.

[0167] It should be understood that the terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. As used in the specification of this application and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are intended to include the plural forms.

[0168] It should also be understood that the term "and / or" used in the specification of this application and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations. It should be noted that in this text, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or system comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent in such process, method, article or system. Without further limitation, an element defined by the statement "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or system comprising that element.

[0169] The serial numbers of the embodiments of the present application above are only for description and do not represent the superiority or inferiority of the embodiments. The above are only specific embodiments of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should be covered by the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A sample analyzer, characterized in that: include: A reaction liquid preparation device, used for adding samples and reagents into the reaction container to prepare a reaction liquid; A reaction device, provided with a reaction position for placing the reaction container and used to provide an incubation place for the reaction liquid in the reaction container; A magnetic separation device, used for performing magnetic separation and cleaning of the reaction liquid in the reaction container, and the magnetic separation device at least includes a magnetic adsorption mechanism for performing magnetic adsorption operations on magnetic particles in the reaction liquid in the reaction container, an injection mechanism for performing a liquid injection operation into the reaction container to clean impurities attached to the surface of the magnetic particles, and an aspiration mechanism for performing a liquid aspiration operation on the liquid in the reaction container, wherein the aspiration mechanism includes a liquid aspiration needle, a first needle moving component for driving the liquid aspiration needle to move, a liquid aspiration pipeline connected to the aspiration needle, and a first power component connected to the liquid aspiration needle through the liquid aspiration pipeline and used to provide liquid aspiration power; and A controller is connected to the magnetic separation device for communication, and when the magnetic separation device performs the magnetic separation cleaning process, the controller is used to: Controlling the liquid injection mechanism to perform a liquid injection operation into the reaction container, controlling the magnetic adsorption mechanism to perform a magnetic adsorption operation on magnetic particles in the reaction liquid in the reaction container, and controlling the liquid aspiration mechanism to perform a liquid aspiration operation on the liquid in the reaction container; The aspiration operation at least includes: controlling the first needle moving assembly to drive the aspiration needle to move below the liquid surface in the reaction container, and controlling the first power assembly to drive the aspiration needle to perform aspiration; After the continuous aspiration time of the aspiration action reaches a preset time, the first needle moving component is controlled to drive the aspiration needle to move above the liquid surface of the liquid in the reaction container; and after the aspiration needle moves above the liquid surface of the liquid in the reaction container, the first power component is controlled to continuously drive the aspiration needle to perform the aspiration action.

2. The sample analyzer according to claim 1, characterized in that: In the process of controlling the first power assembly to drive the liquid aspiration needle to perform the liquid aspiration action, the controller executes: Controlling the liquid aspiration needle to move below the liquid level in the reaction container when the first power assembly is in a closed state; After the aspiration needle moves to a first position below the liquid surface in the reaction container, the first power component is controlled to start to drive the aspiration needle to perform the aspiration action.

3. The sample analyzer according to claim 1, characterized in that: The controller is also used for: By controlling the starting driving time of the aspiration needle by the first power component, the continuous aspiration time corresponding to the aspiration action performed by the aspiration needle below the liquid surface in the reaction container is adjusted.

4. The sample analyzer according to claim 1, characterized in that: The controller is also used for: According to the project parameters of the current detection project of the sample analyzer, the continuous liquid aspiration time corresponding to the liquid aspiration action performed below the liquid surface of the liquid in the reaction container is determined for controlling the first power component to drive the liquid aspiration needle.

5. The sample analyzer according to claim 1, characterized in that: During the magnetic separation cleaning process performed by the magnetic separation device, the controller is further used for: Controlling the liquid injection mechanism to perform the liquid injection operation with a first liquid injection amount into the reaction container, and after the liquid injection operation with the first liquid injection amount is completed, controlling the liquid aspirating mechanism to perform the liquid aspirating operation with a first liquid aspirating amount on the liquid in the reaction container; After the liquid aspiration operation of the first liquid aspiration amount is completed, the liquid injection mechanism is controlled to perform the liquid injection operation of the second liquid aspiration amount on the reaction container, and after the liquid injection operation of the second liquid aspiration amount is completed, the liquid aspiration mechanism is controlled to perform the liquid aspiration operation of the second liquid aspiration amount on the liquid in the reaction container; When the second liquid injection amount is greater than the first liquid injection amount, the second liquid absorption amount is greater than the first liquid absorption amount.

6. The sample analyzer according to claim 1, characterized in that: The controller is also used for: The magnetic separation device is controlled to perform at least two stages of magnetic separation cleaning on the reaction liquid in the reaction container, and in different stages of the magnetic separation cleaning, the injection amount corresponding to the injection operation performed by the injection mechanism into the reaction container increases sequentially with the number of stages corresponding to the magnetic separation cleaning.

7. The sample analyzer according to claim 1, characterized in that: During the magnetic separation cleaning process performed by the magnetic separation device, the controller is further used to: When the reaction container is dispatched to the cleaning position, controlling the liquid suction mechanism to perform the liquid suction operation on the liquid in the reaction container; After the liquid aspiration operation is completed, the liquid aspiration mechanism is controlled to perform liquid aspiration on the same reaction container located at the same cleaning position.

8. The sample analyzer according to claim 1, characterized in that: During the process in which the magnetic separation device performs the magnetic separation and cleaning on the reaction liquid in the reaction container, the controller is further used to: When the reaction container is dispatched to the cleaning position, the first needle moving component is controlled to drive the liquid-absorbing needle to move below the liquid surface in the reaction container at the cleaning position, and the first power component is controlled to drive the liquid-absorbing needle to perform the liquid-absorbing action; after the continuous liquid-absorbing time of the liquid-absorbing action reaches the preset time, the first needle moving component is controlled to drive the liquid-absorbing needle to move above the liquid surface of the liquid in the reaction container, and after the liquid-absorbing needle moves above the liquid surface of the liquid in the reaction container, the first power component continues to drive the liquid-absorbing needle to perform the liquid-absorbing action; When the duration of the aspiration action performed by the aspiration needle above the liquid surface in the reaction container reaches a first time, the injection mechanism is controlled to move to the same reaction container located at the same cleaning position, and the injection operation is performed on the reaction container.

9. The sample analyzer according to claim 8, characterized in that: Each of the cleaning positions is correspondingly provided with one of the liquid suction mechanisms and one of the liquid injection mechanisms, wherein the liquid injection mechanism comprises a liquid injection needle, a liquid injection pipeline connected to the liquid injection needle, a second needle moving component for driving the liquid injection needle to move, and a second power component connected to the liquid injection needle through the liquid injection pipeline and used for providing liquid injection power; Alternatively, each cleaning position is correspondingly provided with a suction component, and the suction component is formed with a suction channel for sucking liquid from the reaction container and a liquid injection channel for injecting liquid into the reaction container.

10. The sample analyzer according to any one of claims 1 to 9, characterized in that: The sample analyzer is also provided with a first cleaning position and a second cleaning position, and the magnetic separation device performs at least two stages of magnetic separation cleaning on the reaction liquid in the reaction container, and at least one stage of magnetic separation cleaning includes a liquid injection sub-cycle, a magnetic adsorption sub-cycle, a first liquid aspiration sub-cycle and a second liquid aspiration sub-cycle; The controller is also used to: control the injection mechanism to perform the injection operation on the reaction container in the injection sub-cycle; control the magnetic adsorption mechanism to perform the magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction container in the magnetic adsorption sub-cycle; control the aspiration mechanism to perform the aspiration operation on the liquid in the reaction container located at the first cleaning position in the first aspiration sub-cycle; and control the aspiration mechanism to perform the aspiration operation on the liquid in the same reaction container that has completed aspiration from the first cleaning position and is dispatched to the second cleaning position in the second aspiration sub-cycle.

11. The sample analyzer according to claim 10, characterized in that: When the liquid aspiration mechanism performs a liquid aspiration operation at the first cleaning position, the distance between the liquid aspiration needle and the bottom of the reaction container is a first distance; When the liquid aspiration mechanism performs a liquid aspiration operation at the second cleaning position, the distance between the liquid aspiration needle and the bottom of the reaction container is a second distance, and the second distance is less than or equal to the first distance.

12. The sample analyzer according to any one of claims 1 to 9, characterized in that: The magnetic separation cleaning comprises a liquid injection sub-cycle, a magnetic adsorption sub-cycle and a liquid absorption sub-cycle; The controller is further used to: control the liquid injection mechanism to perform the liquid injection operation into the reaction container in the liquid injection sub-period, control the magnetic adsorption mechanism to perform the magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction container in the magnetic adsorption sub-period, and control the liquid aspiration mechanism to perform the liquid aspiration operation on the liquid in the reaction container in the liquid aspiration sub-period; Among them, the number of the aspiration sub-cycles is N, N is a positive integer, N≥2, and in the Nth aspiration sub-cycle, the first power component drives the aspiration needle to perform the aspiration action below the liquid surface of the reaction container, and the continuous aspiration time corresponding to the aspiration action is the longest.

13. A liquid aspiration control method, applied to a sample analyzer, the method comprising: Controlling the reaction liquid preparation device to add samples and reagents into the reaction container to prepare a reaction liquid; Controlling the magnetic separation device to perform magnetic separation and cleaning on the reaction container carrying the reaction liquid, the magnetic separation and cleaning comprising: controlling the liquid injection mechanism of the magnetic separation device to perform a liquid injection operation on the reaction container containing the reaction liquid, controlling the magnetic adsorption mechanism of the magnetic separation device to perform a magnetic adsorption operation on the magnetic particles in the reaction liquid in the reaction container, and controlling the liquid aspiration mechanism of the magnetic separation device to perform a liquid aspiration operation on the liquid in the reaction container; The aspiration operation at least includes: controlling the first needle moving component of the aspiration mechanism to drive the aspiration needle of the aspiration mechanism to move below the liquid surface in the reaction container, and controlling the first power component of the aspiration mechanism to drive the aspiration needle to perform the aspiration action; After the continuous aspiration time of the aspiration action reaches a preset time, the first needle moving component is controlled to drive the aspiration needle to move above the liquid surface of the liquid in the reaction container; and after the aspiration needle moves above the liquid surface of the liquid in the reaction container, the first power component is controlled to continuously drive the aspiration needle to perform the aspiration action.

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