Mosquito-repelling and itching-relieving liquid and preparation method thereof

Abstract

The invention belongs to the technical field of daily chemical products, and provides mosquito-repelling and itching-relieving liquid and a preparation method thereof.The mosquito-repelling and itching-relieving liquid is prepared from, by mass, 0.1-1 part of mint essential oil, 0.1-1 part of rosemary essential oil, 0.01-1 part of geniposide, 0.01-0.3 part of sodium hyaluronate, 3-5 parts of water, 10-40 parts of eucalyptus citriodora essential oil, 0.01-1 part of phenoxyethanol and 50-87 parts of mint hydrolat. Essential oil and hydrolat are extracted from mint, rosemary and lemon eucalyptus leaves, the components are definite in effect, safe and free of toxic and side effects, natural plants are fully utilized, the resource utilization rate is increased, and the bacteriostatic, nerve soothing and eye-catching effects of the product are improved. Essential oil and hydrolat in various plant raw materials such as mint, rosemary and lemon eucalyptus leaves are extracted by adopting a traditional process, active pharmaceutical ingredients in natural plants are well protected, and the method is green, pollution-free, free of solvent residues and beneficial to mass production conversion.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, and in particular to a mosquito repellent and itching relieving liquid and a preparation method thereof. Background Art

[0002] As residents' daily health awareness increases, daily chemical products will continue to increase for a long time in the future, and the market size of human skin protection products will continue to expand, especially the demand for mosquito repellent and itching relief in daily life, which is indispensable and has become a must-have item for the general public at home and on the go. There are many types of mosquito repellent and itching relief moisturizing spray products on the market, but most of them are added with various chemical synthetic substances, which are generally not easy to degrade and will pollute the environment; in addition, this type of moisturizing spray generally has a single effect and only has moisturizing and skin care functions.

[0003] Chinese patent CN 104887593 A "A pure plant natural mosquito repellent liquid" mainly introduces the mixing and stirring of lemon flavor, lemongrass hydrosol, jojoba oil, and other medicinal material concentrates including mosquito repellents, moisturizers, antipruritic agents, etc., of various types, and some chemical cosolvents, among which the preparation process of the medicinal material concentrate is relatively complicated; Chinese patent CN104688574A "An improved mosquito repellent floral water" introduces the use of chemical repellents such as pyrethrum and chlorpyrifos to repel mosquitoes, and the main solvent used is ethanol, which will cause certain damage to human skin; Chinese patent CN104920491 A "A pure natural mosquito repellent combination" introduces the mixing of a variety of plant composite extracts such as laurel, eucalyptus, honeysuckle, tuberose, and fly repellent, as well as Mirabilis jalapa essential oil, lavender essential oil, diluents, etc., with complicated processes and relatively simple efficacy.

[0004] Therefore, developing a spray product containing natural plant active ingredients and having multiple functions is a major demand in the protection field. Summary of the invention

[0005] The purpose of the present invention is to overcome the defects in the prior art and provide a mosquito repellent and itching relief liquid and a preparation method thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a mosquito repellent and antipruritic liquid, comprising the following components in parts by weight:

[0008] 0.1-1 part of peppermint essential oil, 0.1-1 part of rosemary essential oil, 0.01-1 part of gardenia glycoside, 0.01-0.3 part of sodium hyaluronate, 3-5 parts of water, 10-40 parts of lemon eucalyptus essential oil, 0.01-1 part of phenoxyethanol, and 50-87 parts of peppermint hydrosol.

[0009] Preferably, the preparation method of the peppermint essential oil and peppermint hydrosol comprises the following steps:

[0010] Peppermint and water are mixed and extracted to obtain peppermint essential oil, which is then distilled to obtain peppermint hydrosol.

[0011] Preferably, the mass ratio of mint to water is 1:10-14;

[0012] The mixing time is 12 to 14 hours; the extraction temperature is 100 to 120° C. and the extraction time is 2 to 6 hours;

[0013] The distillation time is 2 to 3 hours.

[0014] Preferably, the preparation method of the rosemary essential oil comprises the following steps:

[0015] Rosemary essential oil is obtained by mixing rosemary and water and extracting them.

[0016] Preferably, the mass ratio of rosemary to water is 1:10-14;

[0017] The mixing time is 6 to 8 hours; the extraction temperature is 100 to 120° C. and the extraction time is 2 to 6 hours.

[0018] Preferably, the preparation method of lemon eucalyptus essential oil comprises the following steps:

[0019] Lemon eucalyptus essential oil is obtained by mixing lemon eucalyptus and water and extracting them.

[0020] Preferably, the mass ratio of lemon eucalyptus to water is 1:10-14;

[0021] The mixing time is 10 to 12 hours; the extraction temperature is 100 to 120° C. and the extraction time is 4 to 8 hours.

[0022] The present invention also provides a method for preparing the mosquito repellent and antipruritic liquid, comprising the following steps:

[0023] (1) mixing peppermint essential oil and rosemary essential oil to obtain a phase A mixed solution;

[0024] (2) mixing gardenia jasminoides, sodium hyaluronate and water to obtain a phase B mixed solution;

[0025] (3) mixing lemon eucalyptus essential oil, phenoxyethanol and peppermint hydrosol to obtain a phase C mixed solution;

[0026] (4) After the mixed solution of phase B and the mixed solution of phase C are preliminarily mixed, the mixed solution of phase A is added thereto for secondary mixing, and the mixture is allowed to stand to obtain a mosquito repellent and antipruritic liquid.

[0027] Preferably, the mixing time in step (1) is 1 to 5 minutes;

[0028] The mixing time in step (2) is 5 to 10 minutes;

[0029] The mixing time in step (3) is 5 to 30 minutes.

[0030] Preferably, the time for the preliminary mixing in step (4) is 30 to 60 minutes;

[0031] The time of the secondary mixing in step (4) is 30 to 60 minutes;

[0032] The standing time in step (4) is 1 to 72 hours.

[0033] The present invention provides a mosquito repellent and antipruritic liquid, comprising the following components by mass: 0.1-1 part of peppermint essential oil, 0.1-1 part of rosemary essential oil, 0.01-1 part of gardenia glycoside, 0.01-0.3 part of sodium hyaluronate, 3-5 parts of water, 10-40 parts of lemon eucalyptus essential oil, 0.01-1 part of phenoxyethanol, and 50-87 parts of peppermint hydrosol. The present invention extracts essential oil and hydrosol from peppermint, rosemary, and lemon eucalyptus leaves, has clear ingredients and efficacy, is safe and has no toxic side effects, makes full use of natural plants, improves resource utilization, and improves the antibacterial, calming, and eye-catching effects of the product.

[0034] Among them, the main chemical components of peppermint essential oil are menthol, menthone, eucalyptol, pinene or pinene, sabinene hydroxide and pulegone. These ingredients have fresh smell, boost spirits, refresh the mind, anti-inflammatory and analgesic, antibacterial and insecticidal effects; rosemary essential oil has fresh air, clean and refreshing, antioxidant, anti-inflammatory, bactericidal, insect repellent, anti-aging, sedative and hypnotic, and antiseptic effects; lemon eucalyptus essential oil mainly has antibacterial, insecticidal, antioxidant, anti-inflammatory, heat-clearing, mosquito repellent and other effects. Gardenia glycoside has laxative, analgesic, choleretic, anti-inflammatory, and soft tissue injury treatment effects. These combined effects can achieve a synergistic effect, enhance the repellence of mosquito bites and the reduction of swelling, pain and itching, enhance the calming of human skin, and achieve moisturizing, soothing, antipruritic and anti-inflammatory effects; the main solvent system is peppermint hydrosol, which contains a small amount of chemical ingredients such as menthol, menthone, limonene, eucalyptol, sesquiterpene, etc., with a fresh and refreshing smell; experimental results show that the combination of the above-mentioned several plant essential oils and hydrosols can achieve the best use effect.

[0035] The present invention uses traditional technology to extract essential oils and hydrosols from several plant raw materials such as mint, rosemary, lemon eucalyptus, etc., which plays a good role in protecting the active pharmaceutical ingredients in natural plants. It is green and pollution-free, has no solvent residue, and is also conducive to large-scale production. Through steam extraction, compounding and adding and other process technologies, a variety of natural active substance components are integrated, and mint hydrosol is selected as the main solvent system. Without adding chemical flavors, the product can be rich in fresh, cool, and sweet smells, and the advantages are fully utilized. The products of this project are mild, safe and non-irritating, do not harm human skin, have mature preparation technology, low equipment investment, and overall stable system, and can quickly achieve mass production.

[0036] The invention realizes antibacterial and anti-inflammatory effects, and the solvent evaporates and is absorbed quickly. The residual substances can repel mosquitoes, relieve itching, inhibit bacteria, reduce inflammation, moisturize, and protect the skin. The skin is moisturized without being tight, and it is safe and non-irritating. Experimental verification shows that the invention meets the requirements of "GB / T Indoor Efficacy Test and Evaluation of Sanitary Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power. The invention meets the requirements of "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", and has significant moisturizing effect on human skin. The invention has a significant reducing effect on redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens pallens that have not sucked blood 4-7 days after emergence. DETAILED DESCRIPTION

[0037] The present invention provides a mosquito repellent and antipruritic liquid, comprising the following components in parts by weight:

[0038] 0.1-1 part of peppermint essential oil, 0.1-1 part of rosemary essential oil, 0.01-1 part of gardenia glycoside, 0.01-0.3 part of sodium hyaluronate, 3-5 parts of water, 10-40 parts of lemon eucalyptus essential oil, 0.01-1 part of phenoxyethanol, and 50-87 parts of peppermint hydrosol.

[0039] In the present invention, the mass fraction of the peppermint essential oil is preferably 0.2 to 0.9 parts, more preferably 0.3 to 0.8 parts, and even more preferably 0.4 to 0.6 parts.

[0040] In the present invention, the mass fraction of the rosemary essential oil is preferably 0.2 to 0.9 parts, more preferably 0.3 to 0.8 parts, and more preferably 0.4 to 0.6 parts.

[0041] In the present invention, the mass fraction of the geniposide is preferably 0.1 to 0.9 parts, more preferably 0.2 to 0.8 parts, and even more preferably 0.4 to 0.6 parts.

[0042] In the present invention, the mass fraction of the sodium hyaluronate is preferably 0.05 to 0.25 parts, more preferably 0.1 to 0.2 parts, and even more preferably 0.14 to 0.16 parts.

[0043] In the present invention, the mass fraction of water is preferably 3.5 to 4.5 parts, more preferably 3.6 to 4.4 parts, and even more preferably 3.8 to 4.2 parts.

[0044] In the present invention, the mass fraction of the lemon eucalyptus essential oil is preferably 15 to 35 parts, more preferably 20 to 30 parts, and more preferably 24 to 26 parts.

[0045] In the present invention, the mass fraction of phenoxyethanol is preferably 0.1 to 0.9 parts, more preferably 0.2 to 0.8 parts, and even more preferably 0.3 to 0.7 parts.

[0046] In the present invention, the mass fraction of the mint hydrosol is preferably 52 to 85 parts, more preferably 55 to 80 parts, and even more preferably 60 to 70 parts.

[0047] In the present invention, the preparation method of the peppermint essential oil and peppermint hydrosol comprises the following steps:

[0048] Peppermint and water are mixed and extracted to obtain peppermint essential oil, which is then distilled to obtain peppermint hydrosol.

[0049] In the present invention, the mass ratio of the mint to water is preferably 1:10-14, more preferably 1:11-13, and even more preferably 1:11.5-12.5.

[0050] In the present invention, the mixing time is preferably 12 to 14 hours, more preferably 12.5 to 13.5 hours, and more preferably 12.8 to 13.2 hours; the extraction temperature is preferably 100 to 120°C, more preferably 105 to 115°C, and more preferably 108 to 112°C; the time is preferably 2 to 6 hours, more preferably 3 to 5 hours, and more preferably 3.5 to 4.5 hours.

[0051] In the present invention, an oily substance is extracted, and the oily substance is taken out and then distilled. The taken out oily substance is dried using anhydrous sodium sulfate, and filtered to obtain peppermint essential oil.

[0052] In the present invention, the distillation time is preferably 2 to 3 hours, more preferably 2.2 to 2.8 hours, and more preferably 2.4 to 2.6 hours. The distilled water is filtered to obtain mint hydrosol.

[0053] In the present invention, the preparation method of rosemary essential oil comprises the following steps:

[0054] Rosemary essential oil is obtained by mixing rosemary and water and extracting them.

[0055] In the present invention, the mass ratio of rosemary to water is preferably 1:10-14, more preferably 1:11-13, and more preferably 1:11.5-12.5.

[0056] In the present invention, the mixing time is preferably 6 to 8 hours, more preferably 6.5 to 7.5 hours, and more preferably 6.8 to 7.2 hours; the extraction temperature is preferably 100 to 120°C, more preferably 105 to 115°C, and more preferably 108 to 112°C; the time is preferably 2 to 6 hours, more preferably 3 to 5 hours, and more preferably 3.5 to 4.5 hours.

[0057] In the present invention, an oily substance is obtained by extraction, and the oily substance is dried using anhydrous sodium sulfate, and filtered to obtain rosemary essential oil.

[0058] In the present invention, the preparation method of lemon eucalyptus essential oil comprises the following steps:

[0059] Lemon eucalyptus essential oil is obtained by mixing lemon eucalyptus and water and extracting them.

[0060] In the present invention, the mass ratio of eucalyptus citriodora to water is preferably 1:10-14, more preferably 1:11-13, and even more preferably 1:11.5-12.5.

[0061] In the present invention, the mixing time is preferably 10 to 12 hours, more preferably 10.5 to 11.5 hours, and more preferably 10.8 to 11.2 hours; the extraction temperature is preferably 100 to 120°C, more preferably 105 to 115°C, and more preferably 108 to 112°C; the time is preferably 4 to 8 hours, more preferably 4.5 to 7.5 hours, and more preferably 5 to 7 hours.

[0062] In the present invention, an oily substance is obtained by extraction, and the oily substance is dried using anhydrous sodium sulfate, and filtered to obtain lemon eucalyptus essential oil.

[0063] The present invention also provides a method for preparing the mosquito repellent and antipruritic liquid, comprising the following steps:

[0064] (1) mixing peppermint essential oil and rosemary essential oil to obtain a phase A mixed solution;

[0065] (2) mixing gardenia jasminoides, sodium hyaluronate and water to obtain a phase B mixed solution;

[0066] (3) mixing lemon eucalyptus essential oil, phenoxyethanol and peppermint hydrosol to obtain a phase C mixed solution;

[0067] (4) After the mixed solution of phase B and the mixed solution of phase C are preliminarily mixed, the mixed solution of phase A is added thereto for secondary mixing, and the mixture is allowed to stand to obtain a mosquito repellent and antipruritic liquid.

[0068] In the present invention, the mixing time in step (1) is preferably 1 to 5 min, more preferably 1.5 to 4.5 min, and even more preferably 2 to 3 min.

[0069] In the present invention, the mixing time in step (2) is preferably 5 to 10 minutes, more preferably 6 to 9 minutes, and even more preferably 7 to 8 minutes.

[0070] In the present invention, the mixing time in step (3) is preferably 5 to 30 min, more preferably 10 to 25 min, more preferably 15 to 20 min; the temperature is preferably 20 to 30°C, more preferably 22 to 28°C, more preferably 24 to 26°C.

[0071] In the present invention, the time for the preliminary mixing in step (4) is preferably 30 to 60 min, more preferably 35 to 55 min, and even more preferably 40 to 50 min.

[0072] In the present invention, the time of the secondary mixing in step (4) is preferably 30 to 60 min, more preferably 35 to 55 min, and even more preferably 40 to 50 min.

[0073] In the present invention, the standing time in step (4) is preferably 1 to 72 hours, more preferably 10 to 60 hours, and even more preferably 30 to 40 hours.

[0074] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0075] Example 1

[0076] Mix mint and water in a mass ratio of 1:12, soak for 13 hours, and heat in an oil bath at 110°C for 4 hours to obtain an oily substance; after taking out the oily substance, continue to distill for 2.5 hours to obtain distilled water; dry the oily substance using anhydrous sodium sulfate, and filter to obtain mint essential oil; filter the distilled water to obtain mint hydrosol.

[0077] Rosemary and water were mixed in a mass ratio of 1:12, and after soaking for 7 hours, the mixture was heated in an oil bath at 110°C for extraction for 4 hours to obtain an oily substance; the oily substance was dried using anhydrous sodium sulfate, and the rosemary essential oil was obtained by filtration.

[0078] Lemon eucalyptus and water were mixed in a mass ratio of 1:12, and after soaking for 11 hours, heated in an oil bath at 110°C for extraction for 6 hours to obtain an oily substance; the oily substance was dried using anhydrous sodium sulfate, and filtered to obtain lemon eucalyptus essential oil.

[0079] Take 0.5 parts of peppermint essential oil and 0.1 parts of rosemary essential oil and mix them for 5 minutes to obtain a phase A mixed solution; take 1 part of gardenia glycoside, 0.3 parts of sodium hyaluronate and 5 parts of water and mix them for 10 minutes to obtain a phase B mixed solution; take 30 parts of lemon eucalyptus essential oil, 0.1 parts of phenoxyethanol and 63 parts of peppermint hydrosol and mix them at 25°C for 20 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 40 minutes, then add the phase A mixed solution and continue mixing for 40 minutes, and let it stand for 40 hours to obtain a mosquito repellent and antipruritic liquid.

[0080] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Sanitary Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 6 hours.

[0081] This embodiment is tested according to the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", the test environment temperature is 20.1-21.4°C, the relative humidity is 44.0-55.3%, which meets the requirements of the scheme design, 32 subjects are aged 25-52 years old, and the average age is 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 12.38%; the moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after four weeks of product use (p<0.001), and the increase rate is 20.28%.

[0082] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4 to 7 days after emergence, and the itching completely disappears after 15 minutes.

[0083] Example 2

[0084] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0085] Take 0.4 parts of peppermint essential oil and 0.2 parts of rosemary essential oil and mix them for 3 minutes to obtain a phase A mixed solution; take 1 part of gardenia glycoside, 0.3 parts of sodium hyaluronate and 4 parts of water and mix them for 8 minutes to obtain a phase B mixed solution; take 40 parts of lemon eucalyptus essential oil, 0.2 parts of phenoxyethanol and 53.9 parts of peppermint hydrosol and mix them at 25°C for 15 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 35 minutes, then add the phase A mixed solution and continue mixing for 35 minutes, and let it stand for 40 hours to obtain a mosquito repellent and antipruritic liquid.

[0086] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 8 hours.

[0087] This embodiment is tested according to the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", the test environment temperature is 20.1-21.4°C, the relative humidity is 44.0-55.3%, which meets the requirements of the scheme design, 32 subjects are aged 25-52 years old, and the average age is 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 12.98%; the moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after four weeks of product use (p<0.001), and the increase rate is 20.98%.

[0088] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0089] Example 3

[0090] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0091] Take 0.3 parts of peppermint essential oil and 0.3 parts of rosemary essential oil and mix them for 4 minutes to obtain a phase A mixed solution; take 0.8 parts of gardenia glycoside, 0.2 parts of sodium hyaluronate and 3 parts of water and mix them for 10 minutes to obtain a phase B mixed solution; take 35 parts of lemon eucalyptus essential oil, 0.1 parts of phenoxyethanol and 60.3 parts of peppermint hydrosol and mix them at 25°C for 20 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 50 minutes, then add the phase A mixed solution and continue mixing for 50 minutes, and let it stand for 50 hours to obtain a mosquito repellent and antipruritic liquid.

[0092] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 7 hours.

[0093] This embodiment is tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with a test environment temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which meets the requirements of the scheme design. The 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", on the premise that no adverse reactions occur according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 12.68%; the moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after four weeks of product use (p<0.001), and the increase rate is 20.68%.

[0094] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0095] Example 4

[0096] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0097] Take 0.6 parts of peppermint essential oil and 0.2 parts of rosemary essential oil and mix them for 2 minutes to obtain a phase A mixed solution; take 0.7 parts of gardenia glycoside, 0.2 parts of sodium hyaluronate and 3 parts of water and mix them for 7 minutes to obtain a phase B mixed solution; take 30 parts of lemon eucalyptus essential oil, 0.2 parts of phenoxyethanol and 65.1 parts of peppermint hydrosol and mix them at 25°C for 10 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 40 minutes, then add the phase A mixed solution and continue mixing for 30 minutes, and let it stand for 50 hours to obtain a mosquito repellent and antipruritic liquid.

[0098] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Sanitary Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 6 hours.

[0099] This embodiment is tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with a test environment temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which meets the requirements of the scheme design. The 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", on the premise that no adverse reactions occur according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the stratum corneum of the cheek is significantly increased (p<0.001) compared with the baseline value (43%) after one week of product use, and the increase rate is 12.26%; the moisture content of the stratum corneum of the cheek is significantly increased (p<0.001) compared with the baseline value after four weeks of product use, and the increase rate is 20.18%.

[0100] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0101] Example 5

[0102] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0103] Take 0.2 parts of peppermint essential oil and 0.4 parts of rosemary essential oil and mix them for 2 minutes to obtain a phase A mixed solution; take 0.8 parts of gardenia glycoside, 0.3 parts of sodium hyaluronate and 3 parts of water and mix them for 6 minutes to obtain a phase B mixed solution; take 20 parts of lemon eucalyptus essential oil, 0.1 parts of phenoxyethanol and 75.2 parts of peppermint hydrosol and mix them at 25°C for 30 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 20°C for 55 minutes, then add the phase A mixed solution and continue mixing for 55 minutes, and let it stand for 2 hours to obtain a mosquito repellent and antipruritic liquid.

[0104] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 5 hours.

[0105] This embodiment is tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with a test environment temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which meets the requirements of the scheme design. The 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", on the premise that no adverse reactions occur according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 11.26%; it is significantly increased compared with the baseline value after four weeks of product use (p<0.001), and the increase rate is 19.68%.

[0106] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0107] Example 6

[0108] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0109] Take 0.1 parts of peppermint essential oil and 0.5 parts of rosemary essential oil and mix them for 4 minutes to obtain a phase A mixed solution; take 0.9 parts of gardenia glycoside, 0.1 parts of sodium hyaluronate and 5 parts of water and mix them for 8 minutes to obtain a phase B mixed solution; take 15 parts of lemon eucalyptus essential oil, 0.2 parts of phenoxyethanol and 78.2 parts of peppermint hydrosol and mix them at 25°C for 10 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 20°C for 50 minutes, then add the phase A mixed solution and continue mixing for 30 minutes, and let it stand for 2 hours to obtain a mosquito repellent and antipruritic liquid.

[0110] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 3 hours.

[0111] This embodiment is tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with a test environment temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which meets the requirements of the scheme design. The 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", on the premise that no adverse reactions occur according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 10.68%; it is significantly increased compared with the baseline value after four weeks of product use (p<0.001), and the increase rate is 19.78%.

[0112] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0113] Example 7

[0114] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0115] Take 0.7 parts of peppermint essential oil and 0.1 parts of rosemary essential oil and mix them for 5 minutes to obtain a phase A mixed solution; take 0.7 parts of gardenia glycoside, 0.3 parts of sodium hyaluronate and 5 parts of water and mix them for 9 minutes to obtain a phase B mixed solution; take 10 parts of lemon eucalyptus essential oil, 0.3 parts of phenoxyethanol and 82.9 parts of peppermint hydrosol and mix them at 25°C for 30 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 40 minutes, then add the phase A mixed solution and continue mixing for 50 minutes, and let it stand for 18 hours to obtain a mosquito repellent and antipruritic liquid.

[0116] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 2 hours.

[0117] This embodiment is tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with a test environment temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which meets the requirements of the scheme design. The 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", on the premise that no adverse reactions occur according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 10.66%; it is significantly increased compared with the baseline value after four weeks of product use (p<0.001), and the increase rate is 19.28%.

[0118] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0119] Example 8

[0120] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0121] Take 0.8 parts of peppermint essential oil and 0.2 parts of rosemary essential oil and mix them for 2 minutes to obtain a phase A mixed solution; take 0.9 parts of gardenia glycoside, 0.3 parts of sodium hyaluronate and 4 parts of water and mix them for 10 minutes to obtain a phase B mixed solution; take 25 parts of lemon eucalyptus essential oil, 0.1 parts of phenoxyethanol and 68.7 parts of peppermint hydrosol and mix them at 25°C for 23 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 50 minutes, then add the phase A mixed solution and continue mixing for 50 minutes, and let it stand for 18 hours to obtain a mosquito repellent and antipruritic liquid.

[0122] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 4 hours.

[0123] This embodiment is tested according to the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", the test environment temperature is 20.1-21.4°C, the relative humidity is 44.0-55.3%, which meets the requirements of the scheme design, and the 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 11.88%; it is significantly increased compared with the baseline value after four weeks of product use (p<0.001), and the increase rate is 19.88%.

[0124] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0125] Example 9

[0126] This example uses the peppermint essential oil, peppermint hydrosol, rosemary essential oil and lemon eucalyptus essential oil prepared in Example 1.

[0127] Take 0.5 parts of peppermint essential oil and 0.5 parts of rosemary essential oil and mix them for 4 minutes to obtain a phase A mixed solution; take 0.8 parts of gardenia glycoside, 0.2 parts of sodium hyaluronate and 3 parts of water and mix them for 8 minutes to obtain a phase B mixed solution; take 20 parts of lemon eucalyptus essential oil, 0.2 parts of phenoxyethanol and 74.8 parts of peppermint hydrosol and mix them at 25°C for 15 minutes to obtain a phase C mixed solution; mix the phase B mixed solution and the phase C mixed solution at 25°C for 40 minutes, then add the phase A mixed solution and continue mixing for 40 minutes, and let it stand for 24 hours to obtain a mosquito repellent and antipruritic liquid.

[0128] This embodiment is based on the requirements of "GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents", and has effective protection for human skin against test insects with qualified attack power, and the protection time is 5 hours.

[0129] This embodiment is tested according to the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", the test environment temperature is 20.1-21.4°C, the relative humidity is 44.0-55.3%, which meets the requirements of the scheme design, and the 32 subjects are aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject uses the test sample as required at the specified time. According to the "Cosmetic Safety Technical Specifications 2015", according to the adverse reaction record results, the product is used continuously for four weeks. The moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after one week of product use (p<0.001), and the increase rate is 11.96%; the moisture content of the skin stratum corneum of the cheek is significantly increased compared with the baseline value (43%) after four weeks of product use (p<0.001), and the increase rate is 20.86%.

[0130] This embodiment has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0131] Comparative Example 1

[0132] The difference between Comparative Example 1 and Example 1 is that no peppermint essential oil is added, the rosemary essential oil is 1 part, and the peppermint hydrosol is 62.6 parts. The rest of the process is the same as Example 1.

[0133] This comparative example is based on the requirements of GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents. It has effective protection for human skin against test insects with qualified attack power, and the protection time is 6 hours.

[0134] This comparative example was tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with an ambient temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which met the requirements of the program design. The 32 subjects were aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject used the test sample as required at the specified time. According to the "Technical Specifications for Safety of Cosmetics 2015", on the premise that no adverse reactions occurred according to the adverse reaction record results, the product was used continuously for four weeks. The moisture content of the stratum corneum of the cheek skin increased significantly (p<0.001) compared with the baseline value (43%) after one week of product use, and the increase rate was 7.83%; it increased significantly (p<0.001) compared with the baseline value after four weeks of product use, and the increase rate was 8.67%.

[0135] This comparative example has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0136] Comparative Example 2

[0137] The difference between Comparative Example 2 and Example 1 is that no rosemary essential oil is contained, the peppermint hydrosol is 63.1 parts, and the other processes are the same as Example 1.

[0138] This comparative example is based on the requirements of GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents. It has effective protection for human skin against test insects with qualified attack power, and the protection time is 6 hours.

[0139] This comparative example was tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with an ambient temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which met the requirements of the program design. The 32 subjects were aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject used the test sample as required at the specified time. According to the "Technical Specifications for Safety of Cosmetics 2015", on the premise that no adverse reactions occurred according to the adverse reaction record results, the product was used continuously for four weeks. The moisture content of the stratum corneum of the cheek skin increased significantly (p<0.001) compared with the baseline value (43%) after one week of product use, and the increase rate was 8.77%; it increased significantly (p<0.001) compared with the baseline value after four weeks of product use, and the increase rate was 9.58%.

[0140] This comparative example has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0141] Comparative Example 3

[0142] The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not contain gardenia glycoside, the amount of mint hydrosol is 64 parts, and the rest of the process is the same as Example 1.

[0143] This comparative example is based on the requirements of GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents. It has effective protection for human skin against test insects with qualified attack power, and the protection time is 6 hours.

[0144] This comparative example was tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with an ambient temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which met the requirements of the program design. The 32 subjects were aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject used the test sample as required at the specified time. According to the "Technical Specifications for Safety of Cosmetics 2015", on the premise that no adverse reactions occurred according to the adverse reaction record results, the product was used continuously for four weeks. The moisture content of the stratum corneum of the cheek skin increased significantly (p<0.001) compared with the baseline value (43%) after one week of product use, and the increase rate was 12.26%; the moisture content of the stratum corneum of the cheek skin increased significantly (p<0.001) compared with the baseline value after four weeks of product use, and the increase rate was 20.18%.

[0145] This comparative example has no effect on reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching still occurs after 15 minutes.

[0146] Comparative Example 4

[0147] The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 does not contain lemon eucalyptus essential oil, the mint hydrosol is 93 parts, and the other processes are the same as Example 1.

[0148] This comparative example is based on the requirements of GB / T Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration Part 9: Repellents, and does not provide effective protection for human skin against test insects with qualified attack power.

[0149] This comparative example was tested in accordance with the "QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", with an ambient temperature of 20.1-21.4°C and a relative humidity of 44.0-55.3%, which met the requirements of the program design. The 32 subjects were aged 25-52 years old, with an average age of 38.44±1.36 years old. Each subject used the test sample as required at the specified time. According to the "Technical Specifications for Safety of Cosmetics 2015", on the premise that no adverse reactions occurred according to the adverse reaction record results, the product was used continuously for four weeks. The moisture content of the stratum corneum of the cheek skin increased significantly (p<0.001) compared with the baseline value (43%) after one week of product use, and the increase rate was 6.26%; it increased significantly (p<0.001) compared with the baseline value after four weeks of product use, and the increase rate was 7.86%.

[0150] This comparative example has a significant effect of reducing the redness, swelling, red spots, pain and itching on human skin caused by female adults of Aedes albopictus or Culex pipiens that have not sucked blood 4-7 days after emergence, and the itching completely disappears after 15 minutes.

[0151] Examples 1 and 2, Comparative Examples 1 to 4 and commercially available antibacterial spray products were subjected to performance tests. The test process and standards are shown in Table 1, and the results are recorded in Table 2.

[0152] Table 1 Test process and standards

[0153]

[0154] Table 2 Test results

[0155]

[0156]

[0157] It can be seen from the above embodiments that the mosquito repellent and antipruritic liquid of the present invention has a strong mosquito repellent and antipruritic effect, and the moisturizing effect is also very obvious. Gardenia glycoside is an cyclopentane compound, which has the effects of anti-inflammatory, anti-inflammatory, analgesic, detumescence and treatment of soft tissue damage. Among different plant essential oils, peppermint essential oil and rosemary essential oil have a good regulating and improving effect on product odor; lemon eucalyptus essential oil has a good mosquito repellent effect; the three essential oils cover volatile components of organic compounds such as alcohols, aldehydes, acids, phenols, esters, ketones and terpenes, and have good antioxidant, anti-inflammatory, nursing and moisturizing effects on human skin, soothing skin function, and the skin moisture content increase rate is also higher than that of using a single essential oil.

[0158] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A mosquito repellent and antipruritic liquid, characterized in that: Contains the following components in parts by weight: 0.1-1 part of peppermint essential oil, 0.1-1 part of rosemary essential oil, 0.01-1 part of gardenia glycoside, 0.01-0.3 part of sodium hyaluronate, 3-5 parts of water, 10-40 parts of lemon eucalyptus essential oil, 0.01-1 part of phenoxyethanol, and 50-87 parts of peppermint hydrosol.

2. The mosquito repellent and antipruritic liquid according to claim 1, characterized in that: The preparation method of the peppermint essential oil and peppermint hydrosol comprises the following steps: Peppermint and water are mixed and extracted to obtain peppermint essential oil, which is then distilled to obtain peppermint hydrosol.

3. The mosquito repellent and antipruritic liquid according to claim 2, characterized in that: The mass ratio of mint to water is 1:10-14; The mixing time is 12 to 14 hours; the extraction temperature is 100 to 120° C. and the extraction time is 2 to 6 hours; The distillation time is 2 to 3 hours.

4. The mosquito repellent and antipruritic liquid according to any one of claims 1 to 3, characterized in that: The preparation method of the rosemary essential oil comprises the following steps: Rosemary essential oil is obtained by mixing rosemary and water and extracting them.

5. The mosquito repellent and antipruritic liquid according to claim 4, characterized in that: The mass ratio of rosemary to water is 1:10-14; The mixing time is 6 to 8 hours; the extraction temperature is 100 to 120° C. and the extraction time is 2 to 6 hours.

6. The mosquito repellent and antipruritic liquid according to claim 1 or 5, characterized in that: The preparation method of the lemon eucalyptus essential oil comprises the following steps: Lemon eucalyptus essential oil is obtained by mixing lemon eucalyptus and water and extracting them.

7. The mosquito repellent and antipruritic liquid according to claim 6, characterized in that: The mass ratio of lemon eucalyptus to water is 1:10-14; The mixing time is 10 to 12 hours; the extraction temperature is 100 to 120° C. and the extraction time is 4 to 8 hours.

8. The method for preparing the mosquito repellent and antipruritic liquid according to any one of claims 1 to 7, characterized in that: It includes the following steps: (1) mixing peppermint essential oil and rosemary essential oil to obtain a phase A mixed solution; (2) mixing gardenia jasminoides, sodium hyaluronate and water to obtain a phase B mixed solution; (3) mixing lemon eucalyptus essential oil, phenoxyethanol and peppermint hydrosol to obtain a phase C mixed solution; (4) After the mixed solution of phase B and the mixed solution of phase C are preliminarily mixed, the mixed solution of phase A is added thereto for secondary mixing, and the mixture is allowed to stand to obtain a mosquito repellent and antipruritic liquid.

9. The method for preparing the mosquito repellent and antipruritic liquid as claimed in claim 8, characterized in that: The mixing time in step (1) is 1 to 5 minutes; The mixing time in step (2) is 5 to 10 minutes; The mixing time in step (3) is 5 to 30 minutes.

10. The method for preparing the mosquito repellent and antipruritic liquid according to claim 8 or 9, characterized in that: The time for the preliminary mixing in step (4) is 30 to 60 minutes; The time of the secondary mixing in step (4) is 30 to 60 minutes; The standing time in step (4) is 1 to 72 hours.

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