An astaxanthin soft capsule and its preparation process

Abstract

The present invention discloses an astaxanthin soft capsule and its preparation process, belonging to the technical field of functional foods. The soft capsule comprises a core and a capsule wall; the core comprises components in the following parts by mass: 90 - 95 parts of astaxanthin oil, 60 - 64 parts of linseed oil, 8 - 12 parts of γ-aminobutyric acid, and 3 - 5 parts of beeswax; the capsule wall comprises components in the following parts by mass: 36 - 40 parts of gelatin, 20 - 24 parts of glycerol, 5 - 7 parts of black pepper extract, and 36 - 40 parts of purified water. The soft capsule obtained by processing the core and capsule wall materials has the advantages of strong stability and good disintegration effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional foods. Specifically, it relates to an astaxanthin soft capsule and its preparation process. Background Art

[0002] Astaxanthin is the only carotenoid in nature that can cross the blood-brain barrier of the human body and has many physiological activities beneficial to human health. In recent years, astaxanthin has attracted much attention in the fields of food, medicine, biology, cosmetics, etc. due to its extremely strong antioxidant property due to its molecular structure.

[0003] Because astaxanthin products in capsule form have advantages such as convenient transportation, easy to carry, controllable dosage, and good swallowability, most oral astaxanthin products adopt this dosage form.

[0004] The stability and bioavailability of astaxanthin capsules are affected by excipients and the capsule wall. By adding existing excipients, soft capsules with controllable astaxanthin dosage can be made and stable preparations, but the stability and disintegration rate can still be further improved to enhance the product quality. Summary of the Invention

[0005] In order to overcome the problems existing in the prior art, the present invention proposes an astaxanthin soft capsule and its preparation process. The present invention improves the stability and bioavailability of astaxanthin in capsules by optimizing the capsule wall formula.

[0006] To achieve the above object, the first aspect of the present invention provides an astaxanthin soft capsule, comprising a core and a capsule wall;

[0007] The core comprises the following components in parts by mass: 90 - 95 parts of astaxanthin oil, 60 - 64 parts of linseed oil, 8 - 12 parts of γ-aminobutyric acid, and 3 - 5 parts of beeswax;

[0008] The capsule wall comprises the following components in parts by mass: 36 - 40 parts of gelatin, 20 - 24 parts of glycerol, 5 - 7 parts of black pepper extract, and 36 - 40 parts of purified water.

[0009] Further, it comprises a core and a capsule wall;

[0010] The core comprises the following components in parts by mass: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax;

[0011] The capsule wall comprises the following components in parts by mass: 38 parts of gelatin, 22 parts of glycerol, 6 parts of black pepper extract, and 38 parts of purified water.

[0012] Further, it comprises a core and a capsule wall;

[0013] The core of the capsule contains the following components in parts by mass: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax;

[0014] The capsule wall contains the following components in parts by mass: 36 parts of gelatin, 20 parts of glycerol, 5 parts of black pepper extract, and 36 parts of purified water.

[0015] Furthermore, it includes the core and the capsule wall;

[0016] The core of the capsule contains the following components in parts by mass: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax;

[0017] The capsule wall contains the following components in parts by mass: 40 parts of gelatin, 24 parts of glycerol, 7 parts of black pepper extract, and 40 parts of purified water.

[0018] The second aspect of the present invention provides a preparation method of the astaxanthin soft capsule described in the first aspect, which includes the following steps:

[0019] S1. Add 50%-60% of the weighed linseed oil and beeswax into a container, stir and heat until melted; cool to 28-32 °C, and then sequentially add the remaining linseed oil, astaxanthin oil, and γ-aminobutyric acid, and perform nanometer treatment: mix by high-speed shearing method, with a shearing time of 10-30 min and a shearing speed of 10000-15000 r / min to obtain a suspension;

[0020] S2. Transfer the suspension prepared in step S1 to a batching tank and evacuate to obtain the core material of the capsule;

[0021] S3. Heat the purified water to 80 °C in a sol tank, first add the black pepper extract, stir and dissolve it, then add glycerol, mix well and heat to 80 °C again, then turn on the vacuum pump, evacuate, keep stirring at a speed of 140-150 rpm / min, suck the gelatin into the sol tank with a feed pipe, after completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and defoam, continue to keep stirring at a speed of 140-150 rpm / min, when the temperature drops below 60 °C, stop the vacuum; heat the mixture to 60-65 °C for standby to obtain the capsule wall material;

[0022] S4. Encapsulate the core material and the capsule wall material with a soft capsule encapsulating machine, wherein the thickness of the capsule wall is controlled at 0.7-0.9 mm.

[0023] The third aspect of the present invention provides the application of the astaxanthin soft capsule described in the first aspect in the preparation of antioxidant drugs, health foods, functional foods, special medical foods, and special dietary foods.

[0024] Through the above technical solutions, the present invention can at least achieve the following beneficial effects: The present invention creatively adds black pepper extract to the raw materials of the capsule wall, which can reduce the fishy smell of astaxanthin while improving the stability and disintegration effect of astaxanthin soft capsules to a certain extent. Detailed implementation mode

[0025] Unless otherwise specified, the materials and reagents used in the present invention are commercially available.

[0026] In the present invention:

[0027] The astaxanthin oil is extracted by our company (Yunnan Green A Bio-Engineering Co., Ltd.) itself, and the astaxanthin content in the astaxanthin oil is 5%.

[0028] The linseed oil is purchased from Heze Zhonghe Jianyuan Biotechnology Co., Ltd.;

[0029] γ-Aminobutyric acid is purchased from Shandong Kangyou Biotechnology Co., Ltd. and sieved through a 80-mesh sieve.

[0030] The beeswax is purchased from Cangzhou Dongfang Beeswax Glue Industry Co., Ltd.;

[0031] The black pepper extract is purchased from Shanyang Lianfeng Biotechnology Co., Ltd. (aqueous extract, specification 20:1);

[0032] The gelatin is purchased from Kunming Sigui Economic and Trade Co., Ltd.;

[0033] The glycerol is purchased from Jiangxi Yipsen Pharmaceutical Co., Ltd.;

[0034] The purified water is prepared by our company (Yunnan Green A Bio-Engineering Co., Ltd.) itself. Example 1

[0035] An astaxanthin soft capsule, comprising a core and a wall;

[0036] The core comprises the following components in parts by mass: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax;

[0037] The wall comprises the following components in parts by mass: 38 parts of gelatin, 22 parts of glycerol, 6 parts of black pepper extract, and 38 parts of purified water.

[0038] The preparation method of the above astaxanthin soft capsule comprises the following steps:

[0039] S1, Add 60% of the weighed linseed oil and beeswax into a container, stir and heat to melt; cool to 30 °C, and then add the remaining linseed oil, astaxanthin and γ-aminobutyric acid in sequence, and adopt nanonization treatment: mix by high-speed shearing method, with a shearing time of 20 min and a shearing speed of 12000 r / min to obtain a suspension;

[0040] S2. Transfer the suspension obtained in step S1 into a batching tank and evacuate it (vacuum degree: 0.07 - 0.08 MPa) to obtain the core material of the capsule.

[0041] S3. Heat purified water to 80°C in a sol tank. First, add black pepper extract, stir to dissolve it, then add glycerol. After mixing evenly, heat it to 80°C again, turn on the vacuum pump, evacuate, keep stirring at a rotation speed of 140 rpm / min, suck gelatin into the sol tank with a feed pipe, after completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and defoam, continue to keep stirring at a rotation speed of 140 rpm / min, when the temperature drops below 60°C, stop the vacuum; heat the mixture to 62°C for standby to obtain the wall material of the capsule.

[0042] S4. Encapsulate the core material and the wall material with a soft capsule encapsulating machine, and control the wall thickness of the capsule to be 0.7 - 0.9 mm. Example 2

[0043] A soft capsule of astaxanthin, comprising a core and a wall.

[0044] The core contains the following components in parts by mass: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax.

[0045] The wall contains the following components in parts by mass: 36 parts of gelatin, 20 parts of glycerol, 5 parts of black pepper extract, and 36 parts of purified water.

[0046] The preparation method of the above soft capsule of astaxanthin comprises the following steps:

[0047] S1. Add 50% of linseed oil and beeswax weighed into a container, stir and heat to melt; cool to 28°C, and successively add the remaining linseed oil, astaxanthin, and γ-aminobutyric acid, and perform nanometer treatment: mix by high-speed shearing method, with a shearing time of 10 min and a shearing rotation speed of 10000 r / min to obtain a suspension.

[0048] S2. Transfer the suspension obtained in step S1 into a batching tank and evacuate it (vacuum degree: 0.07 - 0.08 MPa) to obtain the core material of the capsule.

[0049] S3. Heat the purified water to 80 °C in the sol tank. First, add the black pepper extract and stir until dissolved. Then add glycerol and mix well. After heating to 80 °C again, turn on the vacuum pump, evacuate the air, keep stirring at a speed of 150 rpm / min, and suck the gelatin into the sol tank through the feed pipe. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes. Turn on the vacuum pump, evacuate the air to remove bubbles, continue stirring at a speed of 150 rpm / min. When the temperature drops below 60 °C, stop the vacuum. Heat the mixture to 60 °C for standby to obtain the wall material of the capsule.

[0050] S4. Encapsulate the core material and the wall material of the capsule with a soft capsule encapsulating machine, and control the wall thickness of the capsule to be 0.7 - 0.9 mm. Example 3

[0051] A soft capsule of astaxanthin, comprising a core and a wall.

[0052] The core of the capsule comprises the following components in parts by mass: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax.

[0053] The wall of the capsule comprises the following components in parts by mass: 40 parts of gelatin, 24 parts of glycerol, 7 parts of black pepper extract, and 40 parts of purified water.

[0054] The preparation method of the above astaxanthin soft capsule comprises the following steps:

[0055] S1. Add 60% of the weighed linseed oil and beeswax into a container, stir and heat until melted. Cool to 28 - 32 °C, and then sequentially add the remaining linseed oil, astaxanthin, and γ-aminobutyric acid, and perform nanometer treatment: mix by high-speed shearing method, with a shearing time of min and a shearing speed of 15000 r / min to obtain a suspension.

[0056] S2. Transfer the suspension prepared in step S1 into a batching tank and evacuate the air (vacuum degree: 0.07 - 0.08 MPa) to obtain the core material of the capsule.

[0057] S3. Heat the purified water to 80 °C in the sol tank. First, add the black pepper extract and stir until dissolved. Then add glycerol and mix well. After heating to 80 °C again, turn on the vacuum pump, evacuate the air, keep stirring at a speed of 150 rpm / min, and suck the gelatin into the sol tank through the feed pipe. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes. Turn on the vacuum pump, evacuate the air to remove bubbles, continue stirring at a speed of 150 rpm / min. When the temperature drops below 60 °C, stop the vacuum. Heat the mixture to 65 °C for standby to obtain the wall material of the capsule.

[0058] S4. Encapsulate the core material and the wall material of the capsule with a soft capsule encapsulating machine, wherein the wall thickness of the capsule is controlled to be 0.7 - 0.9 mm.

[0059] Comparative Example 1

[0060] The difference between Comparative Example 1 and Example 1 is that the capsule wall does not contain black pepper extract.

[0061] Test protocol design: According to the guiding principles for the stability test of raw drugs and preparations (Part IV of the Chinese Pharmacopoeia 2020 Edition, 9001), the raw astaxanthin oil of the soft capsules of the present invention and the soft capsules prepared in Examples 1 to 3 and Comparative Example 1 were respectively placed in clean brown glass bottles, and placed for 6 months under the conditions of a temperature of 40°C ± 2°C and a relative humidity of 75% ± 5%. Samples were taken at 0 month, 1 month, 2 months, 3 months, and 6 months respectively to detect the astaxanthin content in the products. The test results are shown in Table 1 below:

[0062] Table 1 Results of product stability investigation

[0063]

[0064] After storing the soft capsules prepared in Examples 1 to 3 and Comparative Example 1 at room temperature in clean brown glass bottles for 30 days, the disintegration time limit was detected according to the disintegration time limit inspection method in the Chinese Pharmacopoeia 2020 Edition under the condition of a 37°C water bath, with water as the medium; 6 soft capsules were used in each group for parallel testing, and the average value was taken to obtain the average disintegration time of this group.

[0065] The disintegration test results are shown in Table 2 below:

[0066] Table 2 Statistical table of product disintegration test results

[0067]

[0068] As can be seen from Table 2 above, the disintegration effect of the soft capsules prepared in Examples 1 to 3 in water is better than that of the soft capsules prepared in Comparative Example 1, and the soft capsules prepared by the present invention have an excellent disintegration effect.

[0069] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not restrictive. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A soft capsule of astaxanthin, characterized in that: It comprises a core and a wall. The core comprises components in the following parts by mass: 90 - 95 parts of astaxanthin oil, 60 - 64 parts of linseed oil, 8 - 12 parts of γ-aminobutyric acid, and 3 - 5 parts of beeswax. The wall comprises components in the following parts by mass: 36 - 40 parts of gelatin, 20 - 24 parts of glycerol, 5 - 7 parts of water extract of black pepper, and 36 - 40 parts of purified water.

2. The astaxanthin soft capsule according to claim 1, wherein: It comprises a core and a wall. The core comprises components in the following parts by mass: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax. The wall comprises components in the following parts by mass: 38 parts of gelatin, 22 parts of glycerol, 6 parts of water extract of black pepper, and 38 parts of purified water.

3. The astaxanthin soft capsule according to claim 1, characterized in that: It comprises a core and a wall. The core comprises components in the following parts by mass: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax. The wall comprises components in the following parts by mass: 36 parts of gelatin, 20 parts of glycerol, 5 parts of water extract of black pepper, and 36 parts of purified water.

4. The astaxanthin soft capsule according to claim 1, wherein: It comprises a core and a wall. The core comprises components in the following parts by mass: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax. The wall comprises components in the following parts by mass: 40 parts of gelatin, 24 parts of glycerol, 7 parts of water extract of black pepper, and 40 parts of purified water.

5. The preparation method of the astaxanthin soft capsule according to any one of claims 1-4, characterized in that: It comprises the following steps: S1. Add 50% - 60% of the weighed linseed oil and beeswax into a container, stir and heat to melt; cool to 28 - 32°C, then successively add the remaining linseed oil, astaxanthin oil and γ-aminobutyric acid, and carry out nanometer treatment: mix by high-speed shearing method, with a shearing time of 10 - 30 min and a shearing speed of 10000 - 15000 r / min to obtain a suspension. S2. Transfer the suspension prepared in step S1 into a batching tank and evacuate to obtain the core material. S3. Heat the purified water to 80°C in a sol tank, first add the water extract of black pepper, stir to dissolve and then add glycerol, mix well and then heat to 80°C again, turn on the vacuum pump, evacuate, keep stirring at a speed of 140 - 150 rpm / min, suck gelatin into the sol tank with a feed pipe, after completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and defoam, continue to keep stirring at a speed of 140 - 150 rpm / min, when the temperature drops below 60°C, stop the vacuum; heat the mixture to 60 - 65°C for standby to obtain the wall material. S4. Encapsulate the core material and the wall material with a soft capsule encapsulating machine, wherein the wall thickness is controlled at 0.7 - 0.9 mm.

6. Use of the astaxanthin soft capsule according to any one of claims 1 - 4 in the preparation of antioxidant drugs, functional foods, and special dietary foods.

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