Traditional Chinese medicine composition for treating oral ulcer as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating oral ulcer as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines: 10-30 parts of ginseng, 10-30 parts of radix ophiopogonis, 5-15 parts of astragalus membranaceus, 5-15 parts of schisandra chinensis, 3-10 parts of pericarpium citri reticulatae, 3-10 parts of liquorice, 5-15 parts of scutellaria baicalensis and 0.1-1 part of borneol. The traditional Chinese medicine composition with scientific and reasonable proportion is provided by taking the traditional Chinese medicine theory as the core and on the basis of the theory of tonifying yin and yang. Animal experiments show that the traditional Chinese medicine composition can significantly reduce the area of the oral ulcer and effectively reduce the levels of proinflammatory factors IL-1beta, IL-6 and TNF-alpha in serum, which indicates that the traditional Chinese medicine composition can have an obvious treatment effect on the oral ulcer. A large number of clinical practices show that the traditional Chinese medicine composition can effectively reduce recurrence of the oral ulcer and relieve attack symptoms, and a new idea and choice are provided for treating the oral ulcer caused by deficiency of both qi and yin.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating oral ulcers, a preparation method thereof, and an application thereof. Background Art

[0002] Oral ulcer is one of the most common oral mucosal diseases in clinical practice, specifically referring to a type of oral mucosal ulcerative lesion with unknown causes, recurrent periodically but with limitations. It is commonly seen on the mucous membranes of the lips, cheeks, soft palate, or gums in the oral cavity. The ulcer surface is generally round or oval, sunken, with a white or yellow center, and surrounded by congested and slightly swollen areas. Once it occurs, it will be accompanied by spontaneous burning sensation and irritating pain, and generally can heal on its own in about 10 days. According to the statistics of "Analysis of the Market Competition Pattern and Industry Market Size of Oral Ulcer Medications in China in 2022", the incidence rate of common oral diseases is as high as 60%, and the incidence rate of oral ulcers is about 30%, ranking first among oral mucosal diseases in terms of prevalence. Among them, intractable recurrent oral ulcers account for 10%. These recurrent patients relapse at least 3 times a year. In recent years, with the deterioration of the environment and the change of the pace of life, the number of relapses is showing an increasing trend year by year. The patients have severe pain, seriously affecting their daily lives.

[0003] Oral ulcer is called "aphtha" in traditional Chinese medicine. Traditionally, its causes are mainly divided into deficiency fire and excess fire. For those with excess fire, the heat of various meridians burns and scorches the mouth, resulting in oral ulcers. For those with deficiency fire, the lung and kidney yin are deficient, and the deficiency fire flares up to the mouth, also causing aphtha. Simply put, the biggest difference between the two causes lies in the amount of the body's own substances, which can also be understood as the quality of the constitution. People with excess fire as the cause usually have a relatively good constitution, and their oral ulcers are caused by the influence of the external damp and hot climate. While people with deficiency fire as the cause are usually not very healthy, such as being tired or staying up late often. This deficiency fire is related to the deficiency of yin fluid in the body and has little to do with the external environment. Therefore, most prescriptions usually adopt the method of clearing heat to treat excess fire, such as Wanglaoji herbal tea, watermelon frost, etc.; while for deficiency fire, the method of nourishing yin (supplementing body fluids) is used to restore balance, such as Kouyanqing granules, turtle jelly, etc.

[0004] Sheng Jiating et al. summarized the current status of drug treatment for oral ulcers in "A Brief Discussion on the Research Status of Drug Treatment for Recurrent Oral Ulcers" and found that Western medicine generally habitually uses anti-inflammatory and pain-relieving drugs, supplemented by glucocorticoids and immunomodulatory drugs, in order to achieve the effects of reducing pain, prolonging the inter-attack period, and promoting self-healing. However, drugs such as hormones have relatively large side effects and cannot achieve the purpose of targeted treatment, and can only play an auxiliary role. Traditional Chinese medicine, on the other hand, adopts a treatment method of combining oral administration and external application, mainly following the view of the theory of zang-fu organs for syndrome differentiation and treatment. For example, for the syndrome of heart fire flaring up, "Xiexin Daochi San" is used for modification, and for the syndrome of yin deficiency and excessive fire, "Zhibai Dihuang Pills" is used for modification, etc. Although the components of each prescription are different, most of them have the functions of clearing heat and detoxifying, promoting granulation and astringing sores, with small adverse reactions and high safety. However, most prescriptions can only relieve the distress for a while, with short-term effects, and there is a lack of unified effective traditional Chinese medicine preparations. Modern research has found that most patients with oral ulcers are troubled by oral ulcers throughout the year, not only limited to the hot summer. Therefore, contemporary traditional Chinese medicine scholars tend to treat oral ulcers from the perspective of yin deficiency, but the effect is often not ideal. Summary of the Invention

[0005] Aiming at the deficiencies of the above-mentioned existing technologies, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating oral ulcers. The composition ratio of this traditional Chinese medicine composition is scientific and reasonable, more targeted for the treatment of oral ulcers in contemporary sub-healthy people, safe for clinical use, and has low adverse reactions.

[0006] The present invention is achieved through the following technical solutions:

[0007] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating oral ulcers, which is made from the following raw materials in parts by weight:

[0008] Ginseng 10 - 30 parts, Ophiopogon japonicus 10 - 30 parts, Astragalus membranaceus 5 - 15 parts, Schisandra chinensis 5 - 15 parts, Tangerine peel 3 - 10 parts, Licorice 3 - 10 parts, Scutellaria baicalensis 5 - 15 parts, Borneol 0.1 - 1 part.

[0009] As a preferred technical solution, in the traditional Chinese medicine composition, the weight fractions of each raw material are as follows:

[0010] Ginseng 15 - 20 parts, Ophiopogon japonicus 15 - 20 parts, Astragalus membranaceus 8 - 10 parts, Schisandra chinensis 8 - 10 parts, Tangerine peel 5 - 8 parts, Licorice 5 - 8 parts, Scutellaria baicalensis 8 - 10 parts, Borneol 0.1 - 0.5 part.

[0011] As a further preferred technical solution, in the traditional Chinese medicine composition, the weight fractions of each raw material are as follows:

[0012] Ginseng 15 parts, Ophiopogon japonicus 15 parts, Astragalus membranaceus 10 parts, Schisandra chinensis 10 parts, Tangerine peel 5 parts, Licorice 5 parts, Scutellaria baicalensis 8 parts, Borneol 0.3 part.

[0013] The present invention takes traditional Chinese medicine theory as the core, upholds the concept of "Yin and Yang complement", ginseng is the main drug, plays the main therapeutic effect of replenishing qi; Ophiopogon japonicus is the ministerial drug, plays the secondary role of nourishing yin; Schisandra chinensis is the adjuvant, assists ginseng and Ophiopogon japonicus to enhance the efficacy, and finally achieves the effects of Qi and Yin, clearing dryness and saving lungs. Astragalus is warm and sweet in nature, has the functions of replenishing qi and raising yang, promoting body fluid and nourishing blood, and can be used with ginseng to enhance the original efficacy; Astragalus as a "holy medicine for sores and carbuncles" can also be used with Schisandra chinensis to enhance the power of draining pus and collecting sores; Licorice can clear away heat and detoxify, reconcile various drugs, and as a drug, each drug can work synergistically. "Chinese Pharmacopoeia" records: "Borneolum has the effects of opening the mind, clearing heat and relieving pain", can treat mouth sores, sore throat, etc., and Borneolum is slightly cold, can restrict the warm nature of ginseng and Astragalus, and is used as an adjuvant with Scutellaria baicalensis, which clears heat and detoxifies, and relieves fire and relieves throat. Modern pharmacological studies have shown that borneol has the effect of promoting transdermal absorption, while scutellaria baicalensis can effectively relieve local discomfort symptoms such as oral sores, swollen and painful gums. Adding tangerine peel as a guiding drug, its pungent and warm nature can guide the replenished qi into the spleen and stomach, so that the qi can run normally. Traditional Chinese medicine regards the spleen and stomach as the source of qi and blood biochemical transformation. If the spleen and stomach are healthy, the diet can nourish the body. Ophiopogon japonicus and tangerine peel "help" each other to increase the moisturizing power. The combination of these drugs has a significant therapeutic effect on the qi and yin deficiency syndrome of oral ulcers.

[0014] In a second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0015] (1) Ginseng is crushed into coarse powder and soaked in 60-70% ethanol, then percolated, the percolation liquid is collected, and concentrated under reduced pressure into a ginseng concentrate;

[0016] (2) soaking the ginseng residue after percolation with Ophiopogon japonicus, Astragalus membranaceus, Schisandra chinensis, Tangerine peel, Licorice root, and Scutellaria baicalensis in water for 0.5-2 hours, and then decocting twice in succession, adding 8-15 times the total weight of the raw materials in water for the first decoction, filtering to obtain a first decoction liquid and a residue, adding 6-12 times the weight of the residue in water to the residue for a second decoction, filtering to obtain a second decoction liquid;

[0017] (3) Concentrating the first decoction and the second decoction under reduced pressure, adding the ginseng concentrate obtained in step (1), letting it stand, absorbing the supernatant, and continuing to concentrate under reduced pressure to obtain a dry paste, and then mixing the dry paste with borneol to obtain the dry paste.

[0018] Preferably, in step (2), the first decoction and the second decoction are both performed for 2-3 hours.

[0019] Preferably, in step (3), the temperature of the reduced pressure concentration is 50-60°C.

[0020] In a third aspect, the present invention provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating oral ulcers. The oral ulcers described in the present invention are applicable to the syndrome of deficiency of both qi and yin, accompanied by recurrent oral ulcers, fatigue, shortness of breath, lack of appetite, restlessness, or nausea, vomiting, dry mouth and throat, feverish sensation in the palms and soles, light yellow urine, dry stools, red tongue with little coating, and thready and rapid pulse and other related symptoms. The medicament includes an effective amount of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. Pharmaceutically acceptable carriers include, but are not limited to, lubricants, pH regulators, penetration enhancers, plasticizers, antioxidants, preservatives, etc.

[0021] The medicament of the present invention can be prepared according to conventional methods in the art. The dosage forms of the medicament include oral liquids, granules, sprays, powders, sprays, capsules, patches or tablets.

[0022] Compared with the prior art, the present invention has the following advantages:

[0023] The present invention takes the traditional Chinese medicine theory as the core and provides a traditional Chinese medicine composition with a scientific and reasonable ratio based on the theory of "tonifying both yin and yang". Animal experiments show that the traditional Chinese medicine composition of the present invention can significantly reduce the area of oral ulcers and effectively reduce the levels of pro-inflammatory factors IL-1β, IL-6, and TNF-α in the serum, indicating that the traditional Chinese medicine composition of the present invention can play an obvious therapeutic role in oral ulcers. A large number of clinical practices show that the traditional Chinese medicine composition of the present invention can effectively reduce the recurrence of oral ulcers and relieve the symptoms during the attack, providing new ideas and options for the treatment of oral ulcers with the syndrome of deficiency of both qi and yin.

[0024] The traditional Chinese medicine composition of the present invention is more targeted for the treatment of oral ulcers in contemporary sub-healthy populations, and has the characteristics of unique compatibility, remarkable curative effect and no toxic side effects. Detailed implementation manners

[0025] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. The described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0026] Example 1: Experiment on the effect on the mouse model of oral ulcers with deficiency of both qi and yin

[0027] I. Preparation of the traditional Chinese medicine composition

[0028] The formula of the traditional Chinese medicine composition for treating oral ulcers is: 15 g of ginseng, 15 g of ophiopogon root, 10 g of astragalus membranaceus, 10 g of schisandra chinensis, 5 g of tangerine peel, 5 g of licorice root, 8 g of scutellaria baicalensis, and 0.3 g of borneol.

[0029] Preparation method:

[0030] (1) The ginseng is crushed into coarse powder, impregnated with 65% ethanol for 24 hours, and then percolated. After collecting 60 times the percolate, it is concentrated under reduced pressure to a concentrated solution 2 - 2.5 times the weight of the raw material.

[0031] (2) The ginseng residue after percolation, along with Ophiopogon japonicus, Astragalus membranaceus, Schisandra chinensis, Citrus reticulata Blanco, Glycyrrhiza uralensis Fisch., and Scutellaria baicalensis Georgi, are soaked in water for 2 hours, and then decocted continuously twice. For the first decoction, 12 times the total weight of the raw material of water is added and decocted for 2 hours. The first decoction liquid and residue are filtered. To the residue, 8 times the weight of the residue of water is added and decocted for 2 hours. After filtering and discarding the residue, the second decoction liquid is obtained.

[0032] (3) The first decoction liquid and the second decoction liquid are concentrated under reduced pressure at 60°C to a concentrated solution 3 - 3.5 times the weight of the raw material. Then, the ginseng concentrated solution is added, and it is allowed to stand for 48 hours. The supernatant is sucked out, and it is continuously concentrated under reduced pressure to obtain a dry extract. After mixing the dry extract evenly with borneol, it is obtained.

[0033] II. Test method

[0034] 1. Model establishment

[0035] The mice are randomly divided into a normal control group, a model control group, a positive control group of Kouyanqing granules, a low-dose group of the traditional Chinese medicine composition, a medium-dose group of the traditional Chinese medicine composition, and a high-dose group of the traditional Chinese medicine composition, with 10 mice in each group. After acclimatizing for 3 days, from the 4th day, the mice in the normal control group are gavaged with an equal amount of clear water for 4 consecutive days. On the 4th day, the mice in the model control group, the positive control group of Kouyanqing granules, the low-dose group of the traditional Chinese medicine composition, the medium-dose group of the traditional Chinese medicine composition, and the high-dose group of the traditional Chinese medicine composition are anesthetized with ether. A small cotton ball is placed at one end of a glass tube with a diameter of 1 mm. The glass tube is placed in 95% phenol solution to soak the cotton ball with the liquid medicine, and then the cotton ball end of the glass tube is placed on the buccal mucosa of one side of the mouse and burned for 30 s to create an ulcer surface. After that, it is observed 24 hours later.

[0036] 2. Grouping and administration

[0037] The mice are treated with high, medium, and low doses respectively. Among them, the low-dose group of the traditional Chinese medicine composition: 4.42 g of crude drug / kg / day, which is equivalent to 1 / 2 of the clinical dosage. The dosage is calculated according to the body weight of the mice and dissolved in 0.8 mL of clear water for gavage, once a day; the medium-dose group of the traditional Chinese medicine composition: 8.84 g of crude drug / kg / day, which is equivalent to the clinical dosage. The dosage is calculated according to the body weight of the mice and dissolved in 0.8 mL of clear water for gavage, once a day; the high-dose group of the traditional Chinese medicine composition: 17.69 g of crude drug / kg / day. The dosage is calculated according to the body weight of the mice and dissolved in 0.8 mL of clear water for gavage, once a day; the normal control group and the model control group are gavaged with 0.2 ml / 10 g of clear water every day. The control group of Kouyanqing granules, the high, medium, and low-dose groups of the traditional Chinese medicine composition are all gavaged with 0.2 ml per 10 g of the body weight of the mice every day.

[0038] 3. Observation and Index Detection

[0039] After modeling, the ulcer area was observed macroscopically, and the ulcer area was measured with a vernier caliper. After the last administration, the mice were anesthetized and blood was collected from the orbital cavity. The serum was taken to determine the content of pro-inflammatory factors using mouse IL-1β, IL-6, TNF-α ELISA kits.

[0040] 4. Experimental Results

[0041] (1) Wound Area Measurement:

[0042] The results showed that no ulcers formed in the normal control group (the area was 0 at each time point). After modeling, ulcers appeared in the model control group on the 1st day with an area of 1.00 mm 2 After ulceration, the area continued to expand until the peak on the 3rd day (2.99 ± 0.10 mm 2 ), and slightly decreased to 2.82 ± 0.33 mm on the 4th day 2 . The positive control (Kouyanqing Granules) and each dose group of the traditional Chinese medicine composition could inhibit the progression of ulcers: the area in the positive control group of Kouyanqing Granules (2.05 ± 0.29 mm 2 ) was significantly lower than that of the model control group from the 2nd day (P < 0.05), and shrank to 1.93 ± 0.25 mm on the 4th day 2 (P < 0.05); the low, medium, and high dose groups of the traditional Chinese medicine composition showed enhanced effects with increasing doses, and the ulcer areas in the medium and high dose groups from the 2nd to 4th days were significantly better than those of the model control group (P < 0.05). See Table 1.

[0043] Table 1 Observation and Wound Area Measurement

[0044]

[0045] Note: "*" P < 0.05 compared with the normal control group; "#" P < 0.05 compared with the model control group.

[0046] (2) Pro-inflammatory factors IL-1β, IL-6, TNF-α in serum:

[0047] The results showed that the positive control (Kouyanqing Granule group) significantly reduced the levels of IL-1β (30.42 ± 2.47 ng / L), IL-6 (40.80 ± 3.11 ng / L) and TNF-α (144.30 ± 10.70 ng / L), with P < 0.05 compared with the model control group. The low-dose group of the traditional Chinese medicine composition only partially improved the inflammation, while for the medium- and high-dose groups, the levels of IL-1β (31.40 ± 3.34, 30.26 ± 6.33 ng / L) and IL-6 (42.34 ± 4.70, 41.34 ± 2.83 ng / L) were significantly different from those of the model control group with P < 0.05. There were significant differences between the medium-, high-dose groups of the traditional Chinese medicine composition and the model control group. The results are shown in Table 2.

[0048] Table 2 Effects of pro-inflammatory factors IL-1β, IL-6, TNF-α in serum

[0049]

[0050] Note: "*" P < 0.05 compared with the normal control group; "#" P < 0.05 compared with the model control group.

[0051] 5. Experimental conclusion

[0052] The above experimental animal data indicate that the traditional Chinese medicine composition of the present invention can significantly reduce the area of oral ulcers and effectively decrease the levels of pro-inflammatory factors IL-1β, IL-6, TNF-α in serum, demonstrating that the traditional Chinese medicine composition of the present invention can play an obvious therapeutic role in oral ulcers.

[0053] Example 2: Clinical cases

[0054] Chen: First visit: Recurrent oral ulcers for 8 years, aggravated for 2 days. Usually, oral ulcers occur irregularly without obvious inducement, and heat-clearing and detoxifying traditional Chinese patent medicines and antibiotics have been taken for a long time with no obvious effect. When coming for diagnosis, multiple small white ulcers can be seen on the oral mucosa, with an area of about 0.3 cm × 0.3 cm, severe pain, unable to sleep at night, dry mouth and thirst, normal urination, dry stools, pale tongue with tooth marks on the sides, and slow and weak pulse. The traditional Chinese medicine diagnosis is oral ulcer (syndrome of qi and yin deficiency). The western medicine diagnosis is recurrent oral ulcer. Treatment: 10 g of ginseng, 10 g of astragalus membranaceus, 15 g of ophiopogon japonicus, 6 g of schisandra chinensis, 5 g of tangerine peel, 5 g of roasted licorice root, 8 g of scutellaria baicalensis, 0.3 g of borneol. Second visit: The number of oral ulcers decreased to some extent and the pain was relieved. The original prescription was taken for another 3 doses. Third visit: Most of the oral ulcers disappeared. The original prescription was taken for another 3 doses. The patient was followed up and the oral ulcers completely healed about 5 days later.

[0055] Li: Initial diagnosis: recurrent oral ulcers for more than 3 years, aggravated for 2 months. The patient has often had oral ulcers since high school, with an average of about 3 months of attacks, and severe pain during attacks. Recently, the number of oral ulcer attacks has increased, about once every half a month. When he came to the clinic, there was an ulcer on the side wall of the mouth, with an area of ​​about 0.5cm×0.6cm, obvious pain, yellow-white mucosa on the ulcer surface, red and swollen around, yellow and white mucosa on the ulcer surface, red tongue with thin yellow fur, and weak pulse. The patient is thin, usually irritable, poor appetite, poor physical strength, not active, and normal bowel movements. Chinese medicine diagnosis: oral ulcers (Qi and Yin deficiency syndrome). Western medicine diagnosis: recurrent oral ulcers. Treatment: 15g ginseng, 6g astragalus, 15g ophiopogon, 6g schisandra, 5g tangerine peel, 5g roasted licorice, 8g scutellaria, 0.3g borneol. 3 pairs (granules), warm water, once a day. Second visit: The patient reported that the pain was significantly relieved and the ulcer surface was significantly reduced after taking the medicine for 2 days. The original prescription was continued for 3 doses. During the follow-up, the patient's oral ulcer healed, the number of attacks decreased, and the pain was improved compared with before.

[0056] Zhang: Initial diagnosis: oral ulcers recurred for 2 years. The patient had repeated ulcers in the mouth for 2 years, which came and went. When the ulcers recurred, they were painful and uncomfortable, affecting eating and sleeping. He had sprayed watermelon frost spray locally, but the effect was not obvious. There are now 3 white ulcers in the mouth, with light red around, pain, pale complexion, fatigue, tasteless mouth, normal bowel movements, red tongue with thin white fur, and fine pulse. The patient denied past history, chronic disease history, surgery and trauma history, denied drug allergy history, and there were no special circumstances in personal and family history. Chinese medicine diagnosis: oral ulcers (Qi and Yin deficiency syndrome). Western medicine diagnosis: recurrent oral ulcers. Treatment: 10g ginseng, 10g astragalus, 10g ophiopogon, 6g schisandra, 5g tangerine peel, 5g licorice, 8g scutellaria, 0.1g borneol. 3 pairs (granules), taken with warm water, once a day. The pain was relieved, the ulcer surface gradually shrank, and fatigue was relieved. The patient continued to take 5 doses of the original prescription. During follow-up, the oral ulcer had healed.

[0057] Cao: Initial diagnosis: oral ulcers have recurred for 2 years. The patient has had repeated oral mucosal erosion and pain without obvious causes since two years ago. He has taken Qingwei San and other fire-clearing prescriptions many times. They were effective at first, but then there were problems such as increased frequency of ulcer attacks and prolonged healing time. The patient is now diagnosed with a yellow-white ulcer of about 0.8cm×0.6cm in the mouth, pain, dry throat and mouth, fatigue, normal bowel movements, pale tongue, tooth marks on the edges, thin white fur, and thin pulse. Chinese medicine diagnosis: oral ulcers (Qi and Yin deficiency syndrome). Western medicine diagnosis: recurrent oral ulcers. Treatment: 10g ginseng, 10g astragalus, 10g ophiopogon, 6g schisandra, 5g tangerine peel, 5g licorice, 5g scutellaria, and 0.1g borneol. 3 pairs (granules), taken with warm water, once a day. Second diagnosis: The ulcer surface is smaller than before, and the pain is relieved. The original prescription is continued for 6 doses. Follow-up showed that the oral ulcer was cured and no recurrence was observed.

[0058] The above clinical data indicate that the traditional Chinese medicine composition of the present invention is applicable to oral ulcers with qi-yin deficiency syndrome, accompanied by recurrent oral ulcers, fatigue, shortness of breath, lack of appetite, restlessness, or symptoms such as nausea and vomiting, dry mouth and throat, feverish sensation in the palms and soles, light yellow urine, dry stools, red tongue with less coating, and thready and rapid pulse.

Claims

1. A Chinese medicine composition for treating oral ulcers, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 10-30 parts of ginseng, 10-30 parts of ophiopogon japonicus, 5-15 parts of astragalus, 5-15 parts of schisandra chinensis, 3-10 parts of tangerine peel, 3-10 parts of liquorice, 5-15 parts of scutellaria baicalensis, and 0.1-1 part of borneol.

2. The Chinese medicine composition according to claim 1, characterized in that: The weight fractions of each raw material are as follows: 15-20 parts of ginseng, 15-20 parts of ophiopogon japonicus, 8-10 parts of astragalus, 8-10 parts of schisandra chinensis, 5-8 parts of tangerine peel, 5-8 parts of liquorice, 8-10 parts of Scutellaria baicalensis, 0.1-0.5 parts of Borneol.

3. The Chinese medicine composition according to claim 2, characterized in that: The weight fractions of each raw material are as follows: 15 parts of ginseng, 15 parts of ophiopogon, 10 parts of astragalus, 10 parts of schisandra, 5 parts of tangerine peel, 5 parts of liquorice, 8 parts of scutellaria, ice 0.3 tablets.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Grinding ginseng into coarse powder and adding 60-70% ethanol to soak and then percolating, collecting the percolation liquid, and concentrating it under reduced pressure to obtain ginseng concentrate; (2) soaking the ginseng residue after percolation with Ophiopogon japonicus, Astragalus membranaceus, Schisandra chinensis, Tangerine peel, Licorice root and Scutellaria baicalensis in water for 0.5-2 hours, and then decocting them twice in succession, adding 8-15 times the total weight of water of the raw materials for the first decoction, filtering to obtain a first decoction liquid and residue, adding 6-12 times the weight of water of the residue to the residue for the second decoction, filtering to obtain a second decoction liquid; (3) The first decoction and the second decoction are concentrated under reduced pressure, and then the ginseng concentrate obtained in step (1) is added, and the mixture is allowed to stand, and the supernatant is absorbed, and the mixture is further concentrated under reduced pressure to obtain a dry paste, and the dry paste is evenly mixed with borneol to obtain the dry paste.

5. The method for preparing the Chinese medicine composition according to claim 4, characterized in that: In step (2), the first decoction and the second decoction are both performed for 2-3 hours.

6. The method for preparing the Chinese medicine composition according to claim 4, characterized in that: In step (3), the temperature of the reduced pressure concentration is 50-60 °C.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicine for treating oral ulcers.

8. The use according to claim 7, characterized in that: The oral ulcer is suitable for Qi and Yin deficiency syndrome, accompanied by symptoms of repeated attacks of oral ulcer.

9. The use according to claim 7, characterized in that: The medicine comprises an effective amount of a traditional Chinese medicine composition and a pharmaceutically acceptable carrier.

10. The use according to claim 7, characterized in that: The dosage form of the drug includes oral liquid, granules, spray, powder, spray, capsule, patch or tablet.

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