Medicinal and edible composition for tonifying spleen and eliminating dampness as well as preparation method and application of medicinal and edible composition

Abstract

The invention belongs to the field of health-care food, and particularly relates to a medicinal and edible composition for tonifying spleen and eliminating dampness as well as a preparation method and application thereof. The medicinal and edible composition comprises the following raw materials in parts by mass: 3-30 parts of codonopsis pilosula, 5-40 parts of lotus seeds, 10-40 parts of coix seeds, 10-40 parts of gordon euryale seeds, 1-15 parts of pericarpium citri reticulatae and 5-30 parts of Chinese wolfberry fruits. Aiming at people with spleen deficiency and dampness with main manifestations of fat body, tired and heavy hands and feet or head and body, weak or astringent mouth, thin or rotten stool and the like, the traditional Chinese medicine composition adopts a traditional Chinese medicine syndrome differentiation and treatment method to tonify the spleen, clear damp and stop diarrhea with astringents; meanwhile, the congenital root is considered, and the kidney yang is regulated. The medicinal and edible composition for tonifying spleen and eliminating dampness can effectively improve the symptoms of fat body, tired and heavy hands and feet or head and body, weak or astringent mouth, thin or rotten stool and the like of people with spleen deficiency and dampness.

Description

Technical Field

[0001] The present invention belongs to the field of health foods, and particularly relates to a medicine and food homologous composition for invigorating the spleen and removing dampness, and a preparation method and application thereof. Background Art

[0002] In the Lingnan region of China, the climate is humid. He Mengyao, a medical expert in Guangdong during the Qing Dynasty, mentioned in "Medical Notes on Dampness" that "due to the low-lying terrain, humidity is extremely strong, with morning and evening fogs and spring and summer rains, and many people are affected by dampness." Moreover, as the spleen corresponds to the earth in the five elements and dampness is the qi of the late summer season, from Major Heat to the Autumn Equinox every year, there are more cases of spleen diseases and dampness diseases. If one stays in such a region and climate for a long time, it is easy to damage the qi of the spleen and stomach, accumulate phlegm-dampness, and present manifestations of spleen deficiency with dampness such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools. However, "dampness causes the most diseases, and people often don't notice the coming of dampness. They only know to avoid cold and wind, but don't know to avoid dampness, because its harm is the slowest, the most hidden, and difficult to detect" (from "General Remarks on Medicine"). Sometimes, even if one is affected by dampness pathogens, there may be no related symptoms, but at this time, it is still necessary to "prevent diseases before they occur". For "preventing diseases before they occur", traditional Chinese medicine advocates taking care of and strengthening the healthy qi of the human body through methods such as dietary nourishment, acupuncture, massage, qigong, and adjusting work and rest.

[0003] Dampness pathogens are heavy, turbid, sticky, and prone to transmission and transformation, often accompanied by other pathogens and difficult to get rid of. Although there are many methods for removing dampness, if the balance between removing pathogens and strengthening the healthy qi is not grasped accurately, it is easy to cause damage to the healthy qi when removing pathogens or stagnation when strengthening the healthy qi, especially for people with spleen deficiency and dampness with unclear symptoms. Since the symptoms of people with spleen deficiency and dampness are not severe, they generally tend to take health products or substitute teas to improve the symptoms. At present, the taking effects of health products or substitute teas on the market for people with spleen deficiency and dampness are not satisfactory, and the symptoms of spleen deficiency and dampness such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools cannot be significantly improved. Therefore, it is necessary to develop a health product or a medicine and food homologous substitute tea that can effectively improve the symptoms of spleen deficiency and dampness in people with spleen deficiency and dampness. Summary of the Invention

[0004] The first object of the present invention is to provide a medicine and food homologous composition for invigorating the spleen and removing dampness. The second object of the present invention is to provide a preparation method of the medicine and food homologous composition for invigorating the spleen and removing dampness. The third object of the present invention is to provide an application of the medicine and food homologous composition for invigorating the spleen and removing dampness.

[0005] According to the first aspect of the present invention, there is provided a medicine and food homologous composition for invigorating the spleen and removing dampness. The raw material composition thereof by mass parts includes: 3 - 30 parts of Codonopsis pilosula, 5 - 40 parts of lotus seeds, 10 - 40 parts of coix seeds, 10 - 40 parts of gorgon fruits, 1 - 15 parts of dried tangerine peel, and 5 - 30 parts of wolfberries.

[0006] The present invention believes that in the Lingnan region, dampness evils are prevalent, and diseases mostly involve spleen deficiency with dampness, often presenting symptoms of spleen deficiency diarrhea. Although the treatment should mainly focus on the method of strengthening the spleen and dispelling dampness, it should also be supplemented by strengthening the kidney and astringing the intestine to stop diarrhea, so as to prevent further consumption of the yang qi in the kidney, which is the congenital foundation, due to continuous diarrhea. For the population with spleen deficiency and dampness mainly manifested as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools, the present invention adopts the method of syndrome differentiation and treatment in traditional Chinese medicine, and proposes a medicated and edible homologous composition of the present invention to strengthen the spleen and dispel dampness, and at the same time astringe the intestine to stop diarrhea; while taking into account the congenital foundation, it also regulates the kidney yang.

[0007] In the formula, Codonopsis pilosula has a sweet taste and a neutral nature, strengthening the spleen and nourishing the stomach, and promoting the transportation of the middle qi; Coix seed has a sweet and light taste and a cool nature, strengthening the spleen, dispelling dampness and stopping diarrhea; the two together serve as the monarch drugs, jointly exerting the effect of strengthening the spleen and dispelling dampness. Lotus seeds and Gorgon fruits have a sweet and astringent taste and a neutral nature. Lotus seeds "are very beneficial to the spleen and stomach, and their astringent nature is most suitable for those with slippery diarrhea, spermatorrhea and loose stools" (Record of Materia Medica Explanation by Yuqiu), and Gorgon fruits "tonify the middle and remove dampness, and its nature is not dry, so it can remove pathogenic water and supplement true water. When used together with various yin-tonifying drugs, it can especially help to add essence, and there is no need to worry about excessive dosage causing more dampness. Gorgon fruits not only benefit essence, but also astringe essence and strengthen the kidney" (New Compilation of Materia Medica). Chinese wolfberry has a sweet taste and a neutral nature, and belongs to the liver, kidney and spleen meridians. "Its taste is thick and pure, so it can nourish yin. There is yang in yin, so it can tonify qi. Therefore, nourishing yin will not lead to decline of yin, and promoting yang can make yang flourish" (Correct Explanation of Materia Medica). Lotus seeds, Gorgon fruits and Chinese wolfberry together serve as the minister drugs. When used in combination with the monarch drugs, it can promote diuresis without damaging yin, and tonify without stagnation, achieving the effects of strengthening the spleen, strengthening the kidney, astringing the intestine and stopping diarrhea. Tangerine peel has a bitter, pungent taste and a warm nature, helping the monarch drug to strengthen the spleen and dispel dampness, and also promoting qi movement and relieving stagnation, and supplementing qi to prevent stagnation, serving as the assistant and guiding drug. The medicated and edible homologous composition of the present invention has a mild nature. The combination of strengthening the spleen and dispelling dampness, taking into account both percolating dampness and astringing the intestine, jointly exerts the effects of strengthening the spleen, dispelling dampness, strengthening the kidney, astringing the intestine and stopping diarrhea, and can significantly improve the clinical symptoms such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools in the population with spleen deficiency and dampness.

[0008] The raw material sources of this formula are as follows:

[0009] Codonopsis pilosula: The roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or Codonopsis tangshen Oliv. of the genus Codonopsis in the family Campanulaceae.

[0010] Lotus seeds: The mature seeds of Nelumbo nucifera Gaertn. of the genus Nelumbo in the family Nymphaeaceae.

[0011] Coix seed: The dried and mature semen of Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf of the genus Coix in the family Poaceae.

[0012] Gorgon Fruit: The mature seed kernel of Euryale ferox Salisb., a plant of the genus Euryale in the water lily family.

[0013] Dried Tangerine Peel: The dried mature pericarp of Citrus reticulata Blanco, a plant of the genus Citrus in the Rutaceae family, and its cultivated varieties.

[0014] Wolfberry Fruit: The mature fruit of Lycium barbarum L., a plant of the Solanaceae family.

[0015] In some embodiments, the coix seed is stir-fried coix seed. After stir-frying, the cold nature of the coix seed is removed, and its ability to strengthen the spleen, remove dampness, and relieve diarrhea is enhanced.

[0016] In some embodiments, the dosage form of the medicine and food homologous composition for strengthening the spleen and removing dampness is an oral solution, powder, or granule.

[0017] In some embodiments, food-acceptable excipients can also be added.

[0018] In some embodiments, the excipient is at least one of a sustained-release agent, excipient, filler, binder, wetting agent, disintegrant, absorption promoter, adsorption carrier, surfactant, and lubricant.

[0019] According to the second aspect of the present invention, there is provided a method for preparing the above-mentioned medicine and food homologous composition for strengthening the spleen and removing dampness. When the dosage form of the medicine and food homologous composition for strengthening the spleen and removing dampness is an oral solution, the preparation method includes the following steps:

[0020] Add the raw materials to 8 - 12 times the weight of water and soak for 20 - 40 minutes, then heat to boiling, maintain gentle boiling for 1 - 2 hours, filter, repeat decocting the filter residue 1 - 2 times, and combine the filtrates to obtain it. After the oral solution cools, it is also sub-packed, thus facilitating carrying and distribution.

[0021] According to the third aspect of the present invention, there is provided a method for preparing the above-mentioned medicine and food homologous composition for strengthening the spleen and removing dampness. When the dosage form of the medicine and food homologous composition for strengthening the spleen and removing dampness is a powder, the preparation method includes the following steps:

[0022] Crush or cut each raw material separately, then pass the crushed or cut raw materials through 10-mesh and 50-mesh sieves respectively. Continue to crush or cut the coarse particles that cannot pass through the 10-mesh sieve, take the powder between the 10-mesh sieve and the 50-mesh sieve, then mix the powder of each raw material according to the ratio, and pack it into a packaging bag and seal it.

[0023] According to the fourth aspect of the present invention, there is provided an application of the above-mentioned medicated and edible homologous composition for strengthening the spleen and removing dampness in the preparation of a medicated and edible homologous health food for improving the symptoms of spleen deficiency with dampness. Specifically, the symptoms of spleen deficiency with dampness include being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools. The medicated and edible homologous health food includes medicated and edible substitute tea, lozenges, and effervescent tablets.

[0024] The raw materials in the medicated and edible homologous composition of the present invention, namely Codonopsis pilosula, lotus seeds, coix seeds, gorgon fruits, tangerine peel, and wolfberries, belong to substances that are "both food and Chinese medicinal materials" (Notification of the Ministry of Health on Further Regulating the Management of Health Food Raw Materials (No. 51

[2002] of the Ministry of Health of the People's Republic of China), Announcement on 9 New Substances that are Both Food and Chinese Medicinal Materials in Accordance with Tradition (No. 9

[2023] )). The raw materials of the formula all belong to Chinese medicinal materials that can be used in health foods, and their sources are safe and reliable.

[0025] The raw materials of the medicated and edible homologous composition for strengthening the spleen and removing dampness of the present invention have the characteristics of being both medicated and edible and having safe medication, and can be prepared into medicated and edible homologous health foods such as medicated and edible substitute tea, lozenges, and effervescent tablets.

[0026] Exemplarily, the preparation method of the medicated and edible substitute tea includes the following steps: drying Codonopsis pilosula, lotus seeds, coix seeds, gorgon fruits, tangerine peel, and wolfberries to a moisture content of <3.0%, removing impurities and inferior raw materials, sterilizing with ultraviolet light, weighing each raw material according to the raw material ratio, and mixing evenly to obtain the product.

[0027] The obtained medicated and edible substitute tea is packaged in a gauze tea bag and brewed with about 100 mL of warm boiled water for drinking when in use. The medicated and edible substitute tea of the present invention has a good improvement effect on symptoms such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools in people with spleen deficiency and dampness, and is suitable for long-term drinking.

[0028] The beneficial effects of the present invention include:

[0029] (1) The medicated and edible homologous composition for strengthening the spleen and removing dampness of the present invention can effectively improve symptoms such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools in people with spleen deficiency and dampness.

[0030] (2) The present invention does not use greasy and highly tonic products, but mainly uses mild and neutral products, supplemented with qi-regulating herbs. Through ingenious compatibility, it can tonify without stagnation, and take into account both the root cause and the symptoms. While strengthening the spleen and promoting diuresis to remove dampness, it also takes into account strengthening the kidney and astringing the intestine to stop diarrhea to prevent excessive diuresis. Clinical studies have shown that the medicated and edible homologous composition for strengthening the spleen and removing dampness of the present invention can significantly improve symptoms such as being overweight, feeling heavy and tired in hands, feet, or the whole body, having a bland or astringent taste in the mouth, and having loose or mushy stools in people with spleen deficiency and dampness. Detailed implementation mode

[0031] The present invention will be further described in detail below in conjunction with specific embodiments. It should be noted that the following embodiments are only for better explaining the content of the present invention and do not limit the scope of protection of the present invention. The process steps not disclosed in the embodiments are prior art. Unless otherwise specified, the following raw materials are commercially available.

[0032] Example 1

[0033] The raw material composition of the oral solution of medicated and edible homologous substances for strengthening the spleen and removing dampness in this example is: 10 g of Codonopsis pilosula, 20 g of lotus seeds, 20 g of stir-fried coix seeds, 30 g of gorgon fruits, 2 g of dried tangerine peel, and 10 g of wolfberries.

[0034] Its preparation method includes the following steps:

[0035] (1) Add the raw materials to 10 times the weight of water and soak for 30 minutes, then heat to boiling, keep slightly boiling for 1 hour, and separate to obtain the first decoction and the medicinal residues; take the medicinal residues obtained after the first decoction, add 8 times the weight of water equivalent to the total mass of the raw materials, heat to boiling, keep slightly boiling for 1 hour, and separate to obtain the second decoction and the medicinal residues; combine the first decoction and the second decoction to obtain the oral solution.

[0036] (2) After cooling the obtained oral solution, package it in portions. This ratio is the amount of medicine for one dose, and the amount of one dose is about 150 mL.

[0037] Example 2

[0038] The raw material composition of the powder of medicated and edible homologous substances for strengthening the spleen and removing dampness in this example is: 10 g of Codonopsis pilosula, 20 g of lotus seeds, 20 g of stir-fried coix seeds, 30 g of gorgon fruits, 2 g of dried tangerine peel, and 10 g of wolfberries.

[0039] Its preparation method includes the following steps:

[0040] (1) Take Codonopsis pilosula, pulverize it, and pass through 10-mesh and 50-mesh sieve meshes at the same time. The coarse particles that cannot pass through the 10-mesh sieve are pulverized continuously, and the powder between the 10-mesh sieve and the 50-mesh sieve is taken;

[0041] (2) Pulverize lotus seeds, stir-fried coix seeds, gorgon fruits, dried tangerine peel, and wolfberries into powder respectively according to the method in step (1);

[0042] (3) Mix the powder of each raw material evenly, put it into a packaging bag, and seal it. When taking, it can be taken with about 150 mL of warm boiled water.

[0043] Example 3

[0044] The raw material composition of the oral solution of medicated and edible homologous substances for strengthening the spleen and removing dampness in this example is: 30 g of Codonopsis pilosula, 40 g of lotus seeds, 40 g of stir-fried coix seeds, 40 g of gorgon fruits, 15 g of dried tangerine peel, and 30 g of wolfberries.

[0045] Its preparation method is the same as that of Example 1.

[0046] Example 4

[0047] The medicated and edible powder for strengthening the spleen and removing dampness in this example has the following raw material composition: 3 g of Codonopsis pilosula, 5 g of lotus seeds, 10 g of stir-fried Coix lacryma-jobi, 10 g of Euryale ferox, 1 g of dried tangerine peel, and 5 g of wolfberries.

[0048] Its preparation method is the same as that of Example 2.

[0049] The medicated and edible oral solution for strengthening the spleen and removing dampness prepared in Example 1 was used for people with spleen deficiency and dampness. The administration method was: one dose per day, with a dose of about 150 mL per dose, taken twice in the morning and evening, and continuously taken for 7 days. The gender, age, symptom information, and follow-up symptom information of 31 patients with spleen deficiency and dampness from August 5, 2024, to August 30, 2024, were collected, and their main symptoms were scored.

[0050] The 31 patients with spleen deficiency and dampness were aged 22 - 67 years old, with an average age of 36.7 years. Among them, 16 were male and 15 were female. The main symptoms before taking the medicine included heaviness of the head and body, tastelessness or astringency in the mouth, loose or mushy stools, etc. The self-symptoms of the 31 patients with spleen deficiency and dampness before and after taking the medicated and edible oral solution for strengthening the spleen and removing dampness in Example 1 were compared, and the results are shown in Table 1.

[0051] Table 1 Statistical analysis table of the effect of the medicated and edible oral solution for strengthening the spleen and removing dampness on the symptoms of patients with spleen deficiency and dampness

[0052]

[0053] It can be seen from Table 1 that after taking the medicated and edible oral solution for strengthening the spleen and removing dampness of the present invention, the average scores of the symptoms of heavy head, tastelessness in the mouth, astringency in the mouth, loose or mushy stools in patients were all lower than those before taking the medicine (P < 0.05), indicating that taking the medicated and edible composition for strengthening the spleen and removing dampness of the present invention is significantly effective in improving the symptoms of heaviness of the head and body, tastelessness in the mouth, astringency in the mouth, loose or mushy stools, etc. in patients with spleen deficiency and dampness.

[0054] The above are only some specific embodiments of the present invention. For those of ordinary skill in the art, without departing from the creative concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A medicine-food composition for strengthening the spleen and removing dampness, characterized in that: The raw material composition comprises, by weight, 3-30 parts of codonopsis pilosula, 5-40 parts of lotus seeds, 10-40 parts of coix seeds, 10-40 parts of euryale seeds, 1-15 parts of tangerine peel and 5-30 parts of wolfberry.

2. The medicine-food composition for strengthening the spleen and removing dampness according to claim 1, characterized in that: The coix seeds are fried coix seeds.

3. The medicine-food composition for strengthening the spleen and removing dampness according to claim 1 or 2, characterized in that: The dosage form of the medicine-food homologous composition for strengthening the spleen and removing dampness is oral solution, powder or granule.

4. The medicine-food composition for strengthening the spleen and removing dampness according to claim 1 or 2, characterized in that: Food-acceptable excipients may also be added.

5. The medicine-food composition for strengthening the spleen and removing dampness according to claim 4, characterized in that: The auxiliary material is at least one of a sustained-release agent, an excipient, a filler, a binder, a wetting agent, a disintegrant, an absorption promoter, an adsorption carrier, a surfactant, and a lubricant.

6. The method for preparing the spleen-strengthening and dampness-eliminating medicinal and edible composition according to any one of claims 1 to 5, characterized in that: When the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is an oral solution, the preparation method thereof comprises the following steps: The raw material is added into 8-12 times of the weight of water and soaked for 20-40 minutes, then heated to boiling, kept slightly boiling for 1-2 hours, filtered, and the filter residue is repeatedly decocted 1-2 times, and the filtrate is combined to obtain the product.

7. The method for preparing the spleen-strengthening and dampness-eliminating medicinal and edible composition according to any one of claims 1 to 5, characterized in that: When the dosage form of the medicine-food homologous composition for strengthening the spleen and removing dampness is a powder, the preparation method thereof comprises the following steps: The raw materials are crushed or chopped separately, and then the crushed or chopped raw materials are passed through 10-mesh and 50-mesh sieves respectively, and the coarse particles that cannot pass through the 10-mesh sieve are further crushed or chopped, and the powder between the 10-mesh sieve and the 50-mesh sieve is taken, and then the raw material powders are mixed according to the proportion, put into the packaging bag, and sealed.

8. Use of the spleen-strengthening and dampness-eliminating medicinal and edible composition according to any one of claims 1 to 5 in the preparation of a medicinal and edible health food for improving the symptoms of spleen deficiency and dampness.

9. The use according to claim 8, characterized in that: The symptoms of spleen deficiency and dampness include obesity, heaviness in hands and feet or head and body, bland or astringent taste in the mouth, and loose or rotten stools.

10. The use according to claim 8 or 9, characterized in that: The medicine-food homologous health-care food comprises medicine-food homologous substitute tea, lozenges and effervescent tablets.

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