Traditional Chinese medicine massage paste for treating ejection fraction retention heart failure and preparation method of traditional Chinese medicine massage paste

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine massage ointment for treating ejection fraction retention heart failure and a preparation method thereof. Poria cocos, cassia twig, radix aconiti carmichaeli, rhizoma zingiberis, rhizoma atractylodis macrocephalae and liquorice are adopted as raw materials and are subjected to proper weight proportioning; wherein radix aconiti lateralis praeparata is a monarch drug, can warm heart yang to dredge vessels, can warm spleen yang to dispel cold in the middle, and can help kidney yang to return to origin in the lower part; the cassia twig is used as a ministerial drug and is used together with the monkshood to jointly achieve the effects of exciting yang qi, warming meridians and dredging collaterals; poria cocos, dried ginger and bighead atractylodes rhizome are used as adjuvant drugs, can tonify the spleen to dissipate dampness, warm the spleen to remove dampness and tonify the spleen to produce water, and have the efficacy of warming yang, dispelling cold and excreting dampness. The liquorice can harmonize all the medicines and has the functions of assistant and guide. The traditional Chinese medicine massage paste treats ejection fraction retention heart failure by combining the comprehensive effects of massage and medicine penetration, the effects of warming and supporting yang qi, dredging water channels, dredging channels and collaterals and dispelling cold and removing stasis accord with the pathogenesis of patients suffering from heart failure, yang deficiency and flooding, and the traditional Chinese medicine massage paste is safe and effective in clinical application.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction and a preparation method thereof. Background Art

[0002] Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome, which refers to the reduction of cardiac diastolic function and compliance rather than systolic function. Although the left ventricular ejection fraction ≥ 50%, it also has typical heart failure symptoms, including exercise intolerance, decreased quality of life, dyspnea, edema, cough, etc.

[0003] Due to the complex pathophysiological mechanism of HFpEF, the current treatment methods are limited and the effects are not good. At present, the intervention means for HFpEF are limited, and the treatment means known to be effective for heart failure with reduced ejection fraction have no definite effect on HFpEF.

[0004] Chinese Patent Document CN116173132A discloses the application of a traditional Chinese medicine composition in the preparation of a drug for treating cardiac senility. The traditional Chinese medicine composition is composed of dodder seeds, wolfberry fruits, schisandra fruits, fructus cnidii, fructus rosae laevigatae, semen allii tuberosi, morinda officinalis, cistanche deserticola, raw rehmannia roots, achyranthes bidentata roots, epimedium, fructus rubi, ginseng, pilose antler, hippocampus, and fructus toosendan. The test results show that the drug can reduce the collagen content in the myocardial tissue of HFpEF rats, reduce the degree of myocardial fibrosis, inhibit left ventricular remodeling, thereby improving the cardiac function of rats, preventing and treating heart failure with preserved ejection fraction, and treating cardiac senility, etc.

[0005] However, the above traditional Chinese medicine composition has problems such as too many medicinal flavors, difficult material collection, high price, unclear medicinal effects, and poor treatment effects. Therefore, there is an urgent need for a traditional Chinese medicine composition that has obvious effects in treating heart failure with preserved ejection fraction, few medicinal flavors, practical operability, high compliance, safety and effectiveness. Summary of the Invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides a traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction, which has remarkable effects, few medicinal flavors and high safety, and a preparation method thereof. The traditional Chinese medicine massage paste of the present invention combines the comprehensive effects of massage and drug penetration to treat heart failure with preserved ejection fraction. Its functions of warming and assisting yang qi, regulating water passage, dredging meridians, dispelling cold and removing stasis fit the pathogenesis of patients with heart failure due to yang deficiency and water flooding, and it is safe and effective in clinical application.

[0007] The technical solution adopted by the present invention is as follows: In the first aspect of the present invention, a traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction is provided, and the raw material components include: 2-4 parts by weight of Poria cocos, 2-4 parts by weight of Cinnamomum cassia, 2-4 parts by weight of Aconitum carmichaelii Debx., 2-4 parts by weight of dried ginger, 1-3 parts by weight of Atractylodes macrocephala Koidz., and 1-3 parts by weight of Glycyrrhiza uralensis Fisch.

[0008] Further preferably, the raw material components of the traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction include: 3 parts by weight of Poria cocos, 3 parts by weight of Cinnamomum cassia, 3 parts by weight of Aconitum carmichaelii Debx., 3 parts by weight of dried ginger, 2 parts by weight of Atractylodes macrocephala Koidz., and 2 parts by weight of Glycyrrhiza uralensis Fisch.

[0009] In the second aspect of the present invention, a preparation method of the traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction is provided, including the following steps: (1) Take the above raw material components according to parts by weight, crush them to obtain various traditional Chinese medicine powders, and set aside; (2) Mix the various traditional Chinese medicine powders obtained in step (1) evenly to obtain a traditional Chinese medicine mixed powder; (3) Add vaseline to the traditional Chinese medicine mixed powder obtained in step (2), and mix well to obtain the traditional Chinese medicine massage paste.

[0010] In step (1), the particle size of the various traditional Chinese medicine powders is 80-100 mesh.

[0011] In step (1), the particle size of each traditional Chinese medicine powder is 90 mesh.

[0012] In step (3), the mass ratio of the traditional Chinese medicine mixed powder to vaseline is 3:5-5:5.

[0013] Application of the traditional Chinese medicine massage paste in the preparation of a drug for treating heart failure with preserved ejection fraction.

[0014] Poria cocos, sweet and light in taste, neutral in nature. Promote diuresis and remove dampness, strengthen the spleen and calm the heart. Used for edema with scanty urine, dizziness and palpitation due to phlegm retention, poor appetite due to spleen deficiency, loose stools, restlessness of the mind, palpitations and insomnia.

[0015] Cinnamomum cassia, pungent and sweet in taste, warm in nature. Induce sweating to relieve the exterior syndrome, warm the channels and collaterals, promote yang qi transformation, and calm the adverse qi. Used for wind-cold cold, cold pain in the epigastrium and abdomen, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, and rushing of qi.

[0016] Aconitum carmichaelii Debx., pungent and sweet in taste, extremely hot in nature. Restore yang and rescue from collapse, tonify fire and assist yang, expel wind, cold and dampness pathogens. Used for yang collapse and profuse sweating, cold limbs and faint pulse, impotence, cold uterus, cold pain in the heart and abdomen, deficiency-cold vomiting and diarrhea, yin-cold edema, yang deficiency with exogenous pathogenic factors, and cold-damp arthralgia.

[0017] Dried ginger, pungent in taste, hot in nature. Warm the middle-jiao and expel cold, restore yang and promote blood circulation in the channels. Treat cold pain in the heart and abdomen, vomiting and diarrhea, cold limbs and faint pulse, cold asthma and cough, wind-cold-damp arthralgia, and yang deficiency with hematemesis, epistaxis, and hematochezia.

[0018] Atractylodes macrocephala, bitter and sweet in taste, warm in nature. Tonifies the spleen, benefits the stomach, eliminates dampness, harmonizes the middle energizer, and prevents miscarriage. Treats weakness of the spleen and stomach qi, loss of appetite, lassitude, qi deficiency, distension, diarrhea, phlegm retention, edema, jaundice, damp impediment, difficult urination, dizziness, spontaneous sweating, and restlessness of the fetal qi.

[0019] Licorice, sweet in taste, neutral in nature. Tonifies the spleen and benefits qi, clears heat and detoxifies, reduces phlegm and relieves cough, alleviates spasm and pain, and harmonizes various medicinal herbs. Used for weakness of the spleen and stomach, lassitude and fatigue, palpitations and shortness of breath, profuse phlegm and cough, spasmodic pain in the epigastric and abdominal regions and the extremities, carbuncles and sores, and relieving the toxicity and potency of medicinal herbs.

[0020] The present invention has the following beneficial effects: The present invention provides a traditional Chinese medicine massage paste for treating heart failure with preserved ejection fraction. By using Poria cocos, Cinnamomum cassia, Aconitum carmichaelii, Zingiber officinale, Atractylodes macrocephala, and Licorice as raw materials and carrying out appropriate weight ratios; among them, Aconitum carmichaelii is the sovereign drug, which can warm the heart yang to promote blood circulation, warm the spleen yang to dispel cold in the middle, and assist the kidney yang to return to its origin; Cinnamomum cassia is the ministerial drug, which, used together with Aconitum carmichaelii, can jointly achieve the effect of invigorating yang qi and warming the channels to promote blood circulation; Poria cocos, Zingiber officinale, and Atractylodes macrocephala are the adjuvant drugs, which strengthen the spleen to resolve dampness, warm the spleen to overcome dampness, and tonify the spleen to control water, and have the effect of warming yang and dispelling cold and promoting diuresis; Licorice, on the one hand, can combine with Cinnamomum cassia to transform yang with pungent and sweet flavors to assist the power of warming and tonifying the middle yang; on the other hand, it can combine with Atractylodes macrocephala to benefit qi and strengthen the spleen, and support the earth to facilitate the control of water; thirdly, it can harmonize various medicinal herbs and function as both an adjuvant and a guiding drug. The above prescription is mainly used for treating: symptoms such as cold intolerance, diarrhea, soreness and weakness of the waist and knees, fatigue, listlessness, pale tongue with white coating, and deep and thready and weak pulse caused by deficiency of spleen and kidney yang and obstruction of meridians; or symptoms such as dyspnea, facial edema, or limb edema, and difficult urination caused by deficiency of spleen and kidney yang and unfavorable qi transformation. Clinically, it can be used for the elderly with deficiency of spleen and kidney yang; or patients with chronic heart failure with deficiency of spleen and kidney. The traditional Chinese medicine massage paste of the present invention treats heart failure with preserved ejection fraction through the combined action of massage and drug penetration. Its effects of warming yang qi, regulating the water passage, dredging the meridians, and dispelling cold and removing stasis conform to the pathogenesis of patients with heart failure due to yang deficiency and fluid retention. It is safe and effective in clinical application. Based on the theory of triple energizer qi transformation, the inventors of the present application verified the significant effect of the traditional Chinese medicine paste massage described in the present invention for treating and intervening in heart failure with preserved ejection fraction through preliminary experiments. Detailed implementation manners

[0021] To make the objectives, technical solutions, and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other implementation manners obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope protected by the present invention.

[0022] Unless otherwise specified, the reagents involved in the detailed implementation manners of the present invention are all commercially available products and can be obtained through commercial channels.

[0023] In the following examples, 1 part by weight represents 1 g.

[0024] Example 1 This example provides a traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction, and the raw material components include: 3 parts by weight of Poria cocos, 3 parts by weight of Cinnamomum cassia, 3 parts by weight of Aconitum carmichaelii, 3 parts by weight of Zingiber officinale, 2 parts by weight of Atractylodes macrocephala, and 2 parts by weight of Glycyrrhiza uralensis.

[0025] The preparation method of the traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction includes the following steps: (1) Take the above raw material components by weight, pulverize them, and obtain each traditional Chinese medicine powder with a particle size of 90 mesh for standby; (2) Mix the traditional Chinese medicine powders obtained in step (1) evenly to obtain a traditional Chinese medicine mixed powder; (3) Add vaseline to the traditional Chinese medicine mixed powder obtained in step (2), and the mass ratio of the traditional Chinese medicine mixed powder to vaseline is 3:5. Mix well to obtain the traditional Chinese medicine massage cream.

[0026] Example 2 This example provides a traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction, and the raw material components include: 2 parts by weight of Poria cocos, 4 parts by weight of Cinnamomum cassia, 2 parts by weight of Aconitum carmichaelii, 4 parts by weight of Zingiber officinale, 1 part by weight of Atractylodes macrocephala, and 3 parts by weight of Glycyrrhiza uralensis.

[0027] The preparation method of the traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction includes the following steps: (1) Take the above raw material components by weight, pulverize them, and obtain each traditional Chinese medicine powder with a particle size of 80 mesh for standby; (2) Mix the traditional Chinese medicine powders obtained in step (1) evenly to obtain a traditional Chinese medicine mixed powder; (3) Add vaseline to the traditional Chinese medicine mixed powder obtained in step (2), and the mass ratio of the traditional Chinese medicine mixed powder to vaseline is 4:5. Mix well to obtain the traditional Chinese medicine massage cream.

[0028] Example 3 This example provides a traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction, and the raw material components include: 4 parts by weight of Poria cocos, 2 parts by weight of Cinnamomum cassia, 4 parts by weight of Aconitum carmichaelii, 2 parts by weight of Zingiber officinale, 3 parts by weight of Atractylodes macrocephala, and 1 part by weight of Glycyrrhiza uralensis.

[0029] The preparation method of the traditional Chinese medicine massage cream for treating heart failure with preserved ejection fraction includes the following steps: (1) Take the above raw material components by weight, pulverize them, and obtain each traditional Chinese medicine powder with a particle size of 100 mesh for standby; (2)Mix the Chinese medicine powders obtained in step (1) evenly to obtain a mixed Chinese medicine powder; (3)Add vaseline to the mixed Chinese medicine powder obtained in step (2). The mass ratio of the mixed Chinese medicine powder to vaseline is 5:5. Mix well to obtain the Chinese medicine massage paste.

[0030] Experimental example Based on the theory of triple energizer qi transformation, through preliminary experiments, explore the accompanying symptoms of the Chinese medicine massage paste obtained in Example 1 of the present invention in patients with heart failure with preserved ejection fraction, and provide supporting evidence for the clinical application of the Chinese medicine massage paste in patients with heart failure with preserved ejection fraction.

[0031] The specific preliminary experiment research is as follows: Select 20 patients with metabolic syndrome who visited the First Department of Cardiovascular Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences from August to September 2024. Among them, there are 10 males and 10 females, with an age of (53.75±12.57) years, a height of (168.05±10.29) cm, and a weight of (85.15±13.58) kg.

[0032] Statistical method: Use SPSS 26.0 software for analysis. Measurement data are expressed as mean ± standard deviation ( ), and paired t test is used for comparison before and after by oneself. P <0.05 indicates that the difference is statistically significant. The results are shown in Table 1.

[0033] Table 1 - Comparison of biochemical indexes before and after treatment ( Project Before treatment After treatment Integrated TCM symptoms score of heart failure 42.95±14.58 18.40±8.65 10.583 ＜0.001 Body weight (kg) 85.15±13.58 83.93±13.88 4.954 ＜0.001 Dosage of diuretics (mg / d) 2.59±0.96 2.09±0.86 3.250 0.004 NSNS Nursing satisfaction 74.95±9.64 87.75±13.23 4.691 ＜0.001 It can be seen from Table 1 that after treatment, there are statistically significant differences in the integral of traditional Chinese medicine symptoms of heart failure, changes in body weight, use of diuretics, and NSNS nursing satisfaction in patients with heart failure compared with before treatment.

[0034] To sum up, the Chinese medicine massage paste of the present invention combines the comprehensive effects of massage and drug penetration to treat heart failure with preserved ejection fraction. Its functions of warming and assisting yang qi, regulating water passages, dredging meridians, and dispelling cold and removing stasis fit the pathogenesis of patients with heart failure due to yang deficiency and water flooding, and it is safe and effective in clinical application.

Claims

1. A Chinese medicine ointment for treating heart failure with preserved ejection fraction, characterized in that: The raw material components include: 2-4 parts by weight of Poria cocos, 2-4 parts by weight of cinnamon twig, 2-4 parts by weight of aconite root, 2-4 parts by weight of dried ginger, 1-3 parts by weight of Atractylodes macrocephala, and 1-3 parts by weight of liquorice.

2. The Chinese medicine ointment for treating heart failure with preserved ejection fraction according to claim 1, characterized in that: The raw material components include: 3 parts by weight of Poria cocos, 3 parts by weight of cinnamon twig, 3 parts by weight of aconite root, 3 parts by weight of dried ginger, 2 parts by weight of Atractylodes macrocephala, and 2 parts by weight of liquorice.

3. The method for preparing the traditional Chinese medicine ointment for treating heart failure with preserved ejection fraction according to any one of claims 1 to 2, characterized in that: The steps include: (1) Taking the above raw material components by weight, crushing them to obtain Chinese medicinal powders for later use; (2) mixing the Chinese medicinal powders obtained in step (1) uniformly to obtain a Chinese medicinal mixed powder; (3) Add vaseline to the Chinese medicine mixed powder obtained in step (2), mix thoroughly and evenly, and obtain the Chinese medicine ointment.

4. The method for preparing the traditional Chinese medicine ointment for treating heart failure with preserved ejection fraction according to claim 3, characterized in that: In step (1), the particle size of each Chinese medicine powder is 80-100 mesh.

5. The method for preparing the traditional Chinese medicine ointment for treating heart failure with preserved ejection fraction according to claim 4, characterized in that: In step (1), the particle size of each Chinese medicine powder is 90 mesh.

6. The method for preparing the traditional Chinese medicine ointment for treating heart failure with preserved ejection fraction according to claim 3, characterized in that: In step (3), the mass ratio of the Chinese medicine mixed powder to vaseline is 3:5-5:

5.

7. Use of the Chinese medicinal ointment according to any one of claims 1 to 2 or the Chinese medicinal ointment prepared by the method according to any one of claims 3 to 6 in preparing a medicament for treating heart failure with preserved ejection fraction.