Self-adhesive bandage for rapidly closing wound and preparation method of self-adhesive bandage

Abstract

The invention discloses a self-adhesive bandage for rapidly closing a wound and a preparation method of the self-adhesive bandage, and particularly relates to the technical field of high-molecular polymer bandings.The preparation method comprises the steps that an alpha, omega-dihydroxyl-terminated ethylene glycol polymer, cyclic oligosaccharide molecules and pure water are mixed, and a polymer solution I is obtained; mixing a cyclic oligosaccharide polymer, a polyether high-molecular compound and pure water to obtain a polymer solution II; mixing and drying the polymer solution I and the polymer solution II to prepare a thin film layer; dissolving a carboxylic acid compound and a protein compound in pure water, and heating to obtain an adhesion layer solution I; adding an ester compound and a keto acid compound into the adhesion layer solution I to obtain an adhesion layer solution II; uniformly dripping the adhesion layer solution II onto the thin film layer prepared in the step S2, and curing the adhesion layer solution II to obtain the bandage; the bandage is stretched, so that crystalline regions in the bandage are arranged in a highly oriented manner, the prepared bandage is high in contraction speed, and the modulus after contraction can be mechanically matched with various human tissues.

Description

Technical Field

[0001] The present invention relates to the technical field of polymer bandages, and more specifically, to a self-adhesive bandage for rapid wound closure and a preparation method thereof. Background Art

[0002] Effective wound closure is crucial for healthcare, and the intervention of bandages helps to stop bleeding, reduce the risk of infection, accelerate wound healing and reduce the probability of scarring.

[0003] Existing stimulus-responsive contraction materials, such as acid-responsive, ultraviolet light-responsive, and temperature-responsive contraction materials, have an incompatible use environment with the physiological environment, and there are problems such as slow contraction rate and mismatch between high modulus and tissue. In contrast, contraction materials driven by physiological conditions (such as water and body fluids) can effectively avoid these problems and precisely align wound edges to promote healing.

[0004] However, none of the above materials can self-adhere, that is, they need external drive to adhere to the human body, which is not conducive to simplifying the surgical operation process. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, an embodiment of the present invention provides a self-adhesive bandage for rapid wound closure and a preparation method thereof. The technical problem to be solved by the present invention is: how to drive a bandage with self-adhesive function to rapidly contract in a physiological environment.

[0006] To achieve the above object, the present invention provides the following technical solution: A preparation method of a self-adhesive bandage for rapid wound closure, including

[0007] S1: Mix an α,ω-dihydroxy ethylene glycol polymer, a cyclic oligosaccharide molecule, and pure water to obtain Polymer Solution I; mix a cyclic oligosaccharide polymer, a polyether polymer compound, and pure water to obtain Polymer Solution II;

[0008] S2: After mixing Polymer Solution I and Polymer Solution II and removing bubbles, heat and dry to form a thin film layer;

[0009] S3: Dissolve a carboxylic acid compound and a protein compound in pure water, uniformly mix and heat to obtain Adhesive Layer Solution I;

[0010] S4: Add an ester compound and a keto acid compound to Adhesive Layer Solution I, and continue stirring until all solids are dissolved to obtain Adhesive Layer Solution II;

[0011] S5: Uniformly drop Adhesive Layer Solution II onto the thin film layer prepared in S2, and cure Adhesive Layer Solution II to obtain the bandage;

[0012] S6: Stretch the bandage to highly orient the crystalline regions inside the bandage.

[0013] In a preferred embodiment, in the polymer solution I of S1, pure water accounts for 82%, the α,ω-dihydroxy-terminated ethylene glycol polymer accounts for 1.6%, and the cyclic oligosaccharide molecules account for 16.4%.

[0014] In a preferred embodiment, in the polymer solution II of S1, pure water accounts for 55.5%, the polyether polymer accounts for 41.7%, and the cyclic oligosaccharide molecules account for 2.8%.

[0015] In a preferred embodiment, the adhesion layer solution I of S2 contains 10 wt% - 20 wt% acrylic acid, 0 - 7 wt% citric acid, and 5 wt% gelatin.

[0016] In a preferred embodiment, the acrylic acid content is 15 wt%.

[0017] In a preferred embodiment, the citric acid content is 3 wt%.

[0018] In a preferred embodiment, the adhesion layer solution II of S3 contains 1 wt% N-hydroxysuccinimide acrylate and 0.2 wt% α-ketoglutaric acid.

[0019] In a preferred embodiment, in S5, an ultraviolet curing device is used to cure the adhesion layer solution II.

[0020] In a preferred embodiment, in S6, a universal tensile testing machine is used to set a preset stress of 2 MPa, stretch the bandage to a stretch ratio of 200%, reset it, and cycle several times.

[0021] A self-adhesive bandage for rapid wound closure is made by the above method.

[0022] Technical effects and advantages of the present invention:

[0023] 1. The bandage has a fast contraction speed, and the modulus after contraction can be mechanically matched with various human tissues.

[0024] 2. The preparation process of the adhesion layer is simple and easy to operate, can self-adhere, has strong adhesion, can fit well with tissues, and is not easy to fall off.

[0025] 3. The bandage has cuttability and self-adhesiveness, and can be widely used for wound closure and hemostasis of skin and organs.

[0026] 4. The preparation process of the bandage is simple and the cost is low, which is convenient for large-scale production from the perspective of industrialization. Description of the Drawings

[0027] The accompanying drawings are used to provide a further understanding of the technical solution of the present invention, and constitute a part of the present invention. The embodiments of the present invention and their descriptions are used to explain the present invention, and do not constitute an improper limitation to the present invention.

[0028] Figure 1 It is a practical schematic diagram of the production and application process of the bandage prepared by the present invention.

[0029] Figure 2 It is a schematic diagram of the adhesion of the bandage in the present invention.

[0030] Figure 3 It is a comparison chart of the citric acid content and the adhesion performance of the bandage in the present invention.

[0031] Figure 4 It is a schematic diagram of tissue wound closure in the present invention.

[0032] Figure 5 It is a schematic diagram of adhesion to tissue in the present invention.

[0033] Figure 6 It is the bandage arrangement styles corresponding to different wounds in the present invention. Detailed implementation manners

[0034] Now, example embodiments will be described more fully with reference to the accompanying drawings. However, the example embodiments can be implemented in various forms and should not be construed as limited to the examples set forth herein; rather, these example embodiments are provided so that this disclosure will be more thorough and complete, and will fully convey the concept of the example embodiments to those skilled in the art. The accompanying drawings are only schematic illustrations of the present disclosure and are not necessarily drawn to scale. The same reference numerals in the drawings denote the same or similar parts, and thus their repeated description will be omitted.

[0035] In addition, the described features, structures, or characteristics can be combined in any suitable manner in one or more example embodiments. In the following description, numerous specific details are provided to give a thorough understanding of the example embodiments of the present disclosure. However, those skilled in the art will realize that the technical solutions of the present disclosure can be practiced without one or more of the specific details, or other methods, components, steps, etc. can be used. In other cases, well-known structures, methods, implementations, or operations are not shown or described in detail to avoid obscuring various aspects of the present disclosure.

[0036] Embodiment

[0037] Such as Figures 1-6 。

[0038] When treating an open wound, some bandages with shrinking ability do not have self-adhesive ability. At this time, doctors need to use additional steps and tools to fix the bandage to the outside of the wound to dress the patient's wound, so as to promote the wound healing speed.

[0039] For example, use medical tape to fit the edge of the bandage attached to the outside of the wound and the human epidermis to fix the bandage.

[0040] For example, in some highly automated surgical disinfection and dressing devices, the bandage winding device can automatically dress the wound, thus achieving high efficiency and reducing the pressure on medical staff.

[0041] However, if a self-adhesive bandage is designed, on the one hand, it simplifies the operation process and difficulty of wound closure, and on the other hand, it may also reduce the expenditure cost of surgical tools.

[0042] The present invention designs a preparation method of a self-adhesive bandage for rapid wound closure, including:

[0043] S1: Uniformly mix ethylene glycol polymer containing 1.6% of α,ω-dihydroxy, 16.4% of cyclic oligosaccharide molecules, and 82% of pure water to obtain polymer solution I; uniformly mix 2.8% of cyclic oligosaccharide polymer, 41.7% of polyether-based polymer compounds, and 55.5% of pure water to obtain polymer solution II;

[0044] S2: After uniformly stirring polymer solution I and polymer solution II and removing bubbles, heat and dry to form a thin film layer. The thickness of the thin film layer is not limited and is specifically designed according to the usage situation;

[0045] S3: Dissolve carboxylic acid compounds containing 15wt% acrylic acid and 3wt% citric acid, and protein compounds containing 5wt% gelatin in pure water, uniformly mix and heat to obtain adhesive layer solution I;

[0046] S4: Add ester compounds containing 1wt% N-hydroxysuccinimide acrylate and keto acid compounds containing 0.2wt% α-ketoglutaric acid to adhesive layer solution I, and continue stirring until all solids are dissolved to obtain adhesive layer solution II;

[0047] S5: Uniformly drop adhesive layer solution II onto the thin film layer prepared in S2, and cure adhesive layer solution II to obtain a bandage;

[0048] S6: Stretch the bandage to make the crystal regions inside the bandage highly oriented.

[0049] Preferably, an ultraviolet curing device is selected to cure adhesive layer solution II in S5 by ultraviolet light.

[0050] Place the adhesion layer solution II of S5 on a horizontal plane, adjust the wavelength of the ultraviolet lamp to 365 nm and the power to 16 W, and cure it at room temperature for 4 hours in an environment with a gentle air flow. Then, completely dry the solution II to graft adhesion molecules on the surface of the bandage. The branched adhesion molecules can change the surface structural properties of the carrier, thereby improving its contraction efficiency in physiological tissues.

[0051] Preferably, measure and record the length, width, and thickness data of the bandage. Set the preset stress to 2 MPa through a universal tensile testing machine, stretch the bandage to a tensile rate of 200% and then reset it to its original state. Perform cyclic stretching in this way to make the crystal regions inside the bandage highly oriented, and rapid contraction driven by physiological conditions can be achieved.

[0052] Preferably, the materials used for the bandage include a composite polymer composed of α,ω-dihydroxy ethylene glycol polymer, polyether-based high molecular compound, and cyclic oligosaccharide. These are all materials with high biocompatibility, low price, and can be mass-produced. Therefore, this method and this product have good economic prospects.

[0053] Preferably, the adhesion layer solution II contains acrylic acid, gelatin, citric acid, N-hydroxysuccinimide acrylate, and α-ketoglutaric acid. The carboxyl groups of the above acids can undergo esterification reactions with the hydroxyl groups on the surface of the thin film layer, so that the thin film layer and the cured adhesion layer solution II are connected by covalent bonds. Covalent bonds are more stable than non-covalent bonds because their electrons are evenly distributed between two atoms, and this kind of bond will not fall off easily, thus providing higher mechanical stability and ensuring a firm connection between the thin film layer and the adhesion layer, which plays a key role in stable adhesion.

[0054] After the adhesion layer is connected to the thin film layer, through the hydrogen bond interaction and the chemical synergistic effect of the side chain of N-hydroxysuccinimide acrylate covalently connecting with the amino and carboxyl groups on the surface of human tissues, that is, reacting with the amino groups abundantly present in human tissues to generate amide covalent bonds, and then realizing adhesion to tissues and excluding the moisture on the surface of human tissues. Citric acid plays a dual role in this study. First, it provides multiple carboxyl groups for esterification reactions with the hydroxyl groups on the surface of the bandage, making the thin film layer and the adhesion layer covalently connected. Second, citric acid helps to repel the N-hydroxysuccinimide side chain outward, increasing the density of N-hydroxysuccinimide and carboxyl groups on the adhesion surface, thereby further improving the adhesion.

[0055] For example, set the mass fractions of citric acid to 0, 3 wt%, 5 wt%, and 7 wt% respectively, and measure the shear strength matching between the bandage and human skin tissue. The results show that when the mass fraction of citric acid is 3 wt%, the shear strength reaches 25.83 MPa. Therefore, 3 wt% is determined as the optimal ratio of the adhesion layer.

[0056] For example, the mass fraction of acrylic acid is selected to be 10 wt% - 20 wt%. When the mass fraction is 15 wt%, the adhesion energy between the bandage and human skin tissue is the strongest.

[0057] For example, the mass fraction of gelatin is selected to be 0 - 10 wt%. When the mass fraction is 5 wt%, the toughness of the bandage is the strongest, which means that when it is subjected to an external force, it can withstand a large deformation without breaking.

[0058] For example, the mass fraction of α-ketoglutaric acid is selected to be 0% - 0.4 wt%. When the mass fraction is 0.2 wt%, it can effectively initiate the polymerization reaction.

[0059] For example, the mass fraction of N-hydroxysuccinimide acrylate is selected to be 0 - 2 wt%. When the mass fraction is 1 wt%, it forms a stable covalent bond with the primary amino group (-NH2) on the tissue. At this time, the adhesion energy between the bandage and the tissue is the highest and it is not easy to fall off.

[0060] Preferably, screen printing technology can be used to fabricate precise patterns on the adhesion layer. The specific method is as follows: The screen is stretched on a frame, and there are holes of specific size (2 cm × 1 cm) on the screen. These holes can selectively allow the adhesion layer solution II to pass through or be blocked, so as to selectively transfer the adhesion layer to the thin film layer. During the printing process, a squeegee applies pressure, enabling the adhesion layer solution II to leak through the mesh holes of the screen onto the thin film layer to form the desired pattern. Among them, by controlling the dosage of the adhesion layer solution II, the size, pattern, and shape of the adhesion layer can be adjusted. This process is easy to scale up production, can significantly reduce production costs, and the screen printing operation is simple, with a wide range of applications, high flexibility, and can quickly and repeatedly achieve pattern replication, ensuring production efficiency and production flexibility.

[0061] It should be noted that the patterned part of the adhered layer molecules will inhibit the shrinkage of the bandage, and the adhesion and shrinkage parts of the bandage can be designed according to the actual situation to ensure excellent wound closure effect and that the bandage at the adhesion site is not easy to fall off.

[0062] For example, when applied to abdominal wound healing, by precisely designing the adhesion and shrinkage properties of the bandage, it is possible to avoid an increase in wound tension or uneven closure caused by excessive shrinkage of the bandage, while ensuring that the adhesion layer can firmly adhere to the abdominal skin, avoiding falling off or discomfort during activities or changes in body position, and achieving abdominal wound healing.

[0063] The thin film layer and the adhesion layer are integrated through screen printing to form an integrated Janus bandage material, that is, one side has adhesiveness and the other side does not. Through such coordinated regulation, it can not only provide stable adhesion force but also achieve rapid shrinkage under physiological conditions.

[0064] In summary, the self - adhesive bandage that can be rapidly contracted driven by physiological conditions prepared by the method of the present invention has the advantages of being arbitrarily cuttable, high contraction rate (within 10 s), high tissue adhesiveness, self - adhesiveness, etc. The stimulus - responsive conditions are simple and can be triggered under physiological conditions. The bandage has a fast contraction speed. The skin elastic modulus of an adult is about 0.9 MPa. After the bandage is triggered under physiological conditions, the modulus of the bandage is about 1.5 MPa, which matches the modulus of human skin tissue. It can meet the needs of various wound closures in vivo and in vitro, and has good application prospects. Moreover, the preparation method of the self - adhesive bandage described in the present invention is simple and has good industrialization prospects.

[0065] The above - mentioned bandage has the advantage of being rapidly contracted driven by physiological conditions, and at the same time has excellent self - adhesive performance. It can be stably adhered to the epidermis by pressing on the tissue for 5 seconds, and can rapidly contract under the drive of liquids such as blood and physiological saline, thereby effectively closing the wound. Rapid wound closure helps to stop bleeding and form blood clots, prevent the generation of tension and infection at the wound site. At the same time, accurate wound alignment helps the myofibroblasts of granulation tissue to be neatly arranged, preventing abnormal scars caused by stress.

[0066] Compared with the prior art, the advantages of this patent include:

[0067] 1. The bandage has a fast contraction speed, and the modulus after contraction can be mechanically matched with various human tissues.

[0068] 2. The preparation process of the adhesion layer is simple and easy to operate, can be self - adhered, has strong adhesion force, can fit well with the tissue, and is not easy to fall off.

[0069] 3. The bandage has cuttability and self - adhesiveness, and can be widely used for wound closure and hemostasis of skin and organs.

[0070] 4. The preparation process of the bandage is simple and the cost is low, which is convenient for large - scale production from the perspective of industrialization.

[0071] Only some exemplary embodiments of the present invention have been described by way of illustration above. Undoubtedly, for those of ordinary skill in the art, without departing from the spirit and scope of the present invention, the described embodiments can be modified in various different ways. Therefore, the above - mentioned drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

[0072] The following points should be noted: First, in the description of this application, it should be noted that unless otherwise specified and defined, the terms "installed", "connected", and "coupled" should be understood in a broad sense. It can be a mechanical connection or an electrical connection, or it can be the internal connection of two components. It can be directly connected. The terms "upper", "lower", "left", "right", etc. are only used to indicate the relative position relationship. When the absolute position of the object being described changes, the relative position relationship may change;

[0073] Second, in the drawings of the disclosed embodiments of the present invention, only the structures related to the disclosed embodiments are involved. For other structures, reference can be made to the general design. Without conflict, the same embodiment and different embodiments of the present invention can be combined with each other;

[0074] Finally, the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing a self-adhesive bandage for rapid wound closure, characterized in that: The method comprises: S1: Mixing α,ω-dihydroxyl-terminated ethylene glycol polymer, cyclic oligosaccharide molecules, and pure water to obtain polymer solution I; mixing cyclic oligosaccharide polymer, polyether polymer compound, and pure water to obtain polymer solution II; S2: mixing polymer solution I and polymer solution II to remove bubbles, and then heating and drying to form a film layer; S3: dissolving the carboxylic acid compound and the protein compound in pure water, uniformly mixing and heating to obtain an adhesion layer solution I; S4: adding the ester compound and the keto acid compound to the adhesion layer solution I, and continuing to stir until the solid is completely dissolved to obtain an adhesion layer solution II; S5: evenly dripping the adhesive layer solution II onto the thin film layer obtained in S2, and curing the adhesive layer solution II to obtain a bandage; S6: The bandage is stretched to allow the crystalline regions inside the bandage to be highly oriented.

2. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: In the polymer solution I of S1, pure water accounts for 82%, α,ω-dihydroxy-terminated ethylene glycol polymer accounts for 1.6%, and cyclic oligosaccharide molecules account for 16.4%.

3. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: In the polymer solution II of S1, pure water accounts for 55.5%, polyether polymer accounts for 41.7%, and cyclic oligosaccharide molecules account for 2.8%.

4. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: The adhesive layer solution I of S2 contains 10wt%-20wt% of acrylic acid, 0-7wt% of citric acid, and 5wt% of gelatin.

5. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 4, characterized in that: The acrylic acid content is 15 wt %.

6. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 4, characterized in that: The citric acid content is 3 wt %.

7. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: The adhesive layer solution II of S3 contains 1 wt % of N-hydroxysuccinimide acrylate and 0.2 wt % of α-ketoglutaric acid.

8. The method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: In the step S5, the adhesive layer solution II is cured by using an ultraviolet curing device.

9. A method for preparing a self-adhesive bandage for rapid wound closure according to claim 1, characterized in that: In S6, a universal tensile testing machine is used to set a preset stress of 2 MPa, and the bandage is stretched to a stretching rate of 200% and then reset, and the cycle is repeated several times.

10. A self-adhesive bandage for rapid wound closure, characterized in that: Prepared by the method described in any one of claims 1 to 9.

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