Diaphragm electrical stimulation method and related device

Abstract

The invention discloses a diaphragm electrical stimulation method and a related device, and the method comprises the steps: a gastrointestinal tube provided with a plurality of electrodes is arranged, and the farthest end of the gastrointestinal tube is located in the stomach or the small intestine; the electrode is arranged on the outer surface of the gastrointestinal tube and used for collecting diaphragm electromyographic signals and amplifying the diaphragm electromyographic signals by 1000 times to 5000 times through the differential amplifier; judging whether the diaphragm has a contraction intention and a respiratory reaction according to the diaphragm electromyographic signal so as to determine whether to trigger electrical stimulation; wherein if the diaphragm electromyographic signals are not detected within the preset time or the diaphragm electromyographic signals are weak and cannot cause enough respiratory response, diaphragm electrical stimulation is started to cause enough respiratory response, and diaphragm disuse atrophy is prevented. The electrical stimulation parameters are dynamically adjusted according to the diaphragm electromyographic signals and the respiratory response of the patient, it is ensured that electrical stimulation occurs at the best time and under the best condition, and therefore the treatment effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical fields of medical devices and electrophysiological signal monitoring, and particularly relates to a method and device for diaphragmatic electrical stimulation, and a computing device. Background Art

[0002] The diaphragm is a muscle-fiber structure located between the chest cavity and the abdominal cavity and is the main respiratory muscle. Abnormalities in the function of the diaphragm or phrenic nerve, or the absence of diaphragmatic contraction and relaxation activities for a long time, may lead to diaphragmatic weakness or disuse atrophy, resulting in a significant decline or loss of functions such as breathing, coughing, and sneezing. In severe cases, it may lead to pneumonia, inability to wean from the ventilator, and even death. The traditional percutaneous diaphragmatic electrical stimulation method usually uses electrodes at fixed positions to transmit electrical stimulation signals to promote diaphragmatic contraction. Due to the lack of the function of real-time adjustment of the amplifier gain, the signal amplification effect is inconsistent. In addition, due to mainly relying on preset current amplitude and frequency, there is a lack of the ability to dynamically adjust according to the real-time diaphragmatic electromyogram signal and the patient's respiratory response.

[0003] To solve the above problems, the present invention proposes a method for diaphragmatic electrical stimulation, which dynamically adjusts the electrical stimulation parameters according to the patient's respiratory response and the diaphragmatic voluntary contraction intention to ensure that the electrical stimulation occurs at the best timing and under the best conditions, thereby improving the treatment effect. Summary of the Invention

[0004] In view of the above problems, the present invention provides a method and device for diaphragmatic electrical stimulation, and a computing device.

[0005] According to one aspect of the present invention, there is provided a method for diaphragmatic electrical stimulation, including:

[0006] A gastrointestinal tube provided with a plurality of electrodes is sent to the stomach or small intestine through the gastrointestinal tract. The electrodes on the wall of the gastrointestinal tube are close to the diaphragm and are used to collect diaphragmatic electromyogram signals and amplify the diaphragmatic electromyogram signals 1000 times to 5000 times through a differential amplifier;

[0007] Judging whether the diaphragm has a voluntary contraction intention and a respiratory response according to the diaphragmatic electromyogram signal to determine whether to trigger electrical stimulation; dynamically adjusting the diaphragmatic electromyogram signal according to the patient's respiratory response and the voluntary contraction intention; wherein, if no diaphragmatic electromyogram signal is detected within a predetermined time or the diaphragmatic electromyogram signal is weak and cannot cause a sufficient respiratory response, electrical stimulation of the diaphragm is started to cause a sufficient respiratory response and prevent diaphragmatic disuse atrophy.

[0008] In an optional manner, the collecting of the diaphragmatic electromyogram signal and amplifying the diaphragmatic electromyogram signal 1000 times to 5000 times through a differential amplifier further includes:

[0009] Real-time measuring the input voltage and output voltage of the amplifier;

[0010] Dynamically adjust the gain of the amplifier according to a preset gain coefficient, a non - linear adjustment factor, and a threshold voltage to ensure that the diaphragmatic electromyogram signal is amplified within the range of 1000 times to 5000 times; wherein, the gain adjustment formula of the amplifier is:

[0011]

[0012] wherein, k is the gain coefficient; γ is the non - linear adjustment factor; V thresh is the threshold voltage of the amplifier; V in is the input voltage; V out is the output voltage.

[0013] In an alternative embodiment, the method further includes:

[0014] Dynamically adjust the diaphragmatic electromyogram signal according to the patient's respiratory response and the voluntary contraction intention; wherein, according to the mean and standard deviation of the diaphragmatic electromyogram signal in the most recent N sampling periods; dynamically adjust the judgment threshold according to a preset significance level coefficient, a time decay constant, and the time interval from the most recent sampling to the current time; and adjust the diaphragmatic electromyogram signal according to the judgment threshold.

[0015] In an alternative embodiment, the method further includes:

[0016] After starting the diaphragmatic electrical stimulation, gradually increase the current amplitude of the diaphragmatic electromyogram signal, wherein the increment calculation formula of the current amplitude is:

[0017]

[0018] wherein, α is the scaling factor; β is the curve parameter; t is the current time; t ref is the reference time point; I max , I min are the maximum and minimum allowable values of the electrical stimulation current; I current is the current electrical stimulation current value; γ is the non - linear adjustment factor.

[0019] In an alternative embodiment, the method further includes:

[0020] After starting the diaphragmatic electrical stimulation, adjust the frequency and pulse width of the diaphragmatic electromyogram signal, wherein the calculation formula of the frequency is:

[0021]

[0022] wherein, f is the variable of the stimulation frequency; f min , f max respectively represent the minimum and maximum allowable values of the stimulation frequency; is the rate of voltage change; f crit is the critical frequency; γ is the non - linear adjustment factor;

[0023] The calculation formula for the pulse width is:

[0024]

[0025] where w is the variable of the pulse width; w min , w max represent the minimum and maximum allowable values of the pulse width respectively; η is the adjustment factor; w crit is the critical pulse width; δ is the non - linear adjustment factor.

[0026] In an alternative way, the calculation of the preset frequency of the diaphragmatic electromyogram signal further includes:

[0027] Based on the patient's age, weight and health status score, calculate the respiratory rate according to a preset empirical formula; where the preset empirical formula for the respiratory rate is:

[0028] RR = a·Age -b ·Weight c ·e d·HealthScore

[0029] where a, b, c, d are empirical coefficients; Age is the patient's age; Weight is the patient's weight; HealthScore is the patient's health status score;

[0030] Calculate the preset frequency according to the difference between the patient's respiratory rate, the current health status score and the reference health status score; where the calculation formula for the preset frequency is:

[0031]

[0032] where HealthScore base is the reference health status score; γ is the non - linear adjustment factor; ΔhealthScore is the difference between the current health status score and the reference health status score.

[0033] In an alternative way, the most distal end of the gastrointestinal tube is located in the stomach or small intestine;

[0034] The multiple electrodes are configured as a circular electrode array;

[0035] The electrodes in the circular electrode array can be electrically stimulated individually or in groups.

[0036] In an alternative embodiment, a plurality of electrode arrays are disposed on the wall of the gastrointestinal tube. The electrode arrays surround the wall of the gastrointestinal tube and are used to collect diaphragmatic electromyogram signals in different regions respectively. The electrode arrays are connected to an independent differential amplifier.

[0037] According to another aspect of the present invention, a diaphragmatic electrical stimulation device is provided, comprising:

[0038] A diaphragmatic electrical signal monitoring module. The gastrointestinal tube is sent to the stomach or small intestine via the gastrointestinal tract. The electrodes on the wall of the gastrointestinal tube are close to the diaphragm and are used to collect diaphragmatic electromyogram signals and amplify the diaphragmatic electromyogram signals by 1000 to 5000 times through a differential amplifier.

[0039] A contraction intention judgment module, including a microprocessor and a digital signal processor, is used to judge the presence of an autonomous contraction intention of the diaphragm according to the diaphragmatic electromyogram signal and trigger electrical stimulation.

[0040] An electrical stimulation control module is used to dynamically adjust the diaphragmatic electromyogram signal according to the patient's respiratory response and the autonomous contraction intention. Among them, if diaphragmatic activity caused by electrical stimulation is not detected within a predetermined time, the current amplitude is gradually increased and the frequency and pulse width of the diaphragmatic electromyogram signal are adjusted to maximize the diaphragmatic contraction efficiency; if a diaphragmatic autonomous contraction signal is not detected within a predetermined time, rhythmic electrical stimulation with a preset frequency is started to prevent diaphragmatic disuse atrophy.

[0041] According to yet another aspect of the present invention, a computing device is provided, comprising: a processor, a memory, a communication interface and a communication bus. The processor, the memory and the communication interface complete communication with each other through the communication bus.

[0042] The memory is used to store at least one executable instruction, and the executable instruction causes the processor to execute the operations corresponding to the above diaphragmatic electrical stimulation method.

[0043] According to the solution provided by the present invention, a gastrointestinal tube with multiple electrodes is provided. The gastrointestinal tube is sent through the gastrointestinal tract to a position close to the diaphragm, and the electrodes are close to the diaphragm for collecting diaphragmatic electromyogram signals and amplifying the diaphragmatic electromyogram signals by 1000 to 5000 times through a differential amplifier; judging the presence of an autonomous contraction intention of the diaphragm according to the diaphragmatic electromyogram signal and triggering electrical stimulation; dynamically adjusting the diaphragmatic electromyogram signal according to the patient's respiratory response and the autonomous contraction intention; wherein, if diaphragmatic activity caused by electrical stimulation is not detected within a predetermined time, the current amplitude is gradually increased and the frequency and pulse width of the diaphragmatic electromyogram signal are adjusted to maximize the diaphragmatic contraction efficiency; if a diaphragmatic autonomous contraction signal is not detected within a predetermined time, rhythmic electrical stimulation with a preset frequency is started to prevent diaphragmatic disuse atrophy. The present invention dynamically adjusts the electrical stimulation parameters according to the patient's respiratory response and the autonomous contraction intention of the diaphragm, ensuring that the electrical stimulation occurs at the best time and under the best conditions, thereby improving the treatment effect.

[0044] The above description is only an overview of the technical solution of the present invention. In order to be able to understand the technical means of the present invention more clearly, it can be implemented according to the content of the description. And in order to make the above and other purposes, features and advantages of the present invention more obvious and understandable, the following specifically describes the embodiments of the present invention. Brief Description of the Drawings

[0045] By reading the following detailed description of the preferred embodiments, various other advantages and benefits will become clear to those of ordinary skill in the art. The drawings are only for the purpose of showing the preferred embodiments and are not considered to be a limitation of the present invention. And throughout the drawings, the same reference numerals are used to represent the same components. In the drawings:

[0046] Figure 1 A flowchart showing the method of diaphragmatic electrical stimulation according to an embodiment of the present invention is shown;

[0047] Figure 2 A framework diagram showing the diaphragmatic electrical stimulation device according to an embodiment of the present invention is shown;

[0048] Figure 3 A structural diagram showing the computing device according to an embodiment of the present invention is shown. Detailed Embodiments

[0049] The exemplary embodiments of the present invention will be described in more detail below with reference to the drawings. Although the exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present invention and to be able to fully convey the scope of the present invention to those skilled in the art.

[0050] Figure 1FIG. 2 is a flow chart of a method for electrical stimulation of the diaphragm muscle according to an embodiment of the present invention. Specifically, Figure 1 As shown, the following steps are included:

[0051] Step S101, a gastrointestinal tube is provided with a plurality of electrodes, which is delivered to a position close to the diaphragm through the gastrointestinal tract, and the electrodes are close to the diaphragm for collecting diaphragm electromyographic signals and amplifying the diaphragm electromyographic signals by 1000 to 5000 times through a differential amplifier.

[0052] In this embodiment, a gastrointestinal tube is used as a carrier, which can enter the stomach through the esophagus and approach the diaphragm. Compared with traditional surgical implantation of electrodes, the surgical trauma is significantly reduced. If multiple diaphragm electrical stimulation treatments are required, they can be easily repeated, reducing the patient's pain and risks, and improving patient acceptance.

[0053] In an optional embodiment, the distal end of the gastrointestinal tube is located in the stomach or small intestine.

[0054] The plurality of electrodes are configured as a ring-shaped electrode array;

[0055] The electrodes in the annular electrode array can be electrically stimulated individually or in groups.

[0056] In an optional manner, a plurality of electrode arrays are provided on the wall of the gastrointestinal tube, the electrode arrays surround the wall of the gastrointestinal tube, and the electrode arrays are used to collect diaphragm electromyographic signals in different regions respectively; the electrode arrays are connected to an independent differential amplifier.

[0057] In this embodiment, the gastrointestinal tube may move due to body position and other reasons. Multiple electrode arrays collect diaphragm electromyographic signals respectively, which can avoid as much as possible that a single electrode array cannot accurately capture the diaphragm electromyographic signals.

[0058] In an optional manner, the collecting of diaphragm electromyographic signals and amplifying the diaphragm electromyographic signals by 1000 to 5000 times through a differential amplifier further comprises:

[0059] Real-time measurement of the input voltage and output voltage of the amplifier;

[0060] According to the preset gain coefficient, nonlinear adjustment factor and threshold voltage, the gain of the amplifier is dynamically adjusted to ensure that the diaphragm electromyographic signal is amplified to a range of 1000 to 5000 times; wherein the gain adjustment formula of the amplifier is:

[0061]

[0062] Where k is the gain coefficient; γ is the nonlinear adjustment factor; V thresh is the threshold voltage of the amplifier; V in Input voltage; Vout is the output voltage.

[0063] In this embodiment, the diaphragmatic electromyogram signal itself has a large dynamic range, and its amplitude will change with factors such as breathing intensity and muscle state. A fixed amplification factor may cause small signals to be submerged in noise, while large signals may cause saturation distortion. By dynamically adjusting the gain, the amplification factor can be adjusted in real time according to the intensity of the input signal, ensuring that signals of any size can be effectively amplified to an appropriate range. Even when the signal intensity fluctuates greatly, the clarity of the signal can be guaranteed.

[0064] Step S102, determining whether the diaphragm has an intention of voluntary contraction and a respiratory response according to the diaphragmatic electromyogram signal to determine whether to trigger electrical stimulation; dynamically adjusting the diaphragmatic electromyogram signal according to the patient's respiratory response and the intention of voluntary contraction; wherein, if the diaphragmatic electromyogram signal is not detected or the diaphragmatic electromyogram signal is weak and cannot cause a sufficient respiratory response within a predetermined time, electrical stimulation of the diaphragm is initiated to cause a sufficient respiratory response to prevent diaphragmatic disuse atrophy.

[0065] In this embodiment, by real-time monitoring of the diaphragmatic electromyogram signal, electrical stimulation of the diaphragm is initiated only when the patient has a respiratory intention or the electromyogram activity is insufficient to support effective breathing, avoiding unnecessary stimulation. When the diaphragm itself cannot generate sufficient respiratory effort, electrical stimulation is initiated to avoid atrophy and functional decline of the diaphragm due to long-term inactivity.

[0066] In an alternative manner, the method further includes:

[0067] Dynamically adjusting the diaphragmatic electromyogram signal according to the patient's respiratory response and the intention of voluntary contraction; wherein, according to the mean and standard deviation of the diaphragmatic electromyogram signal within the most recent N sampling periods; dynamically adjusting the judgment threshold according to a preset significance level coefficient, a time decay constant, and the time interval from the most recent sampling to the current; and adjusting the diaphragmatic electromyogram signal according to the judgment threshold.

[0068] In this embodiment, continuously monitoring the electromyogram signal of the diaphragm and calculating the mean and standard deviation within the most recent N sampling periods can effectively remove noise interference and provide a more stable reference for the intensity of the diaphragm electromyogram signal. Among them, the mean reflects the overall intensity level of the current diaphragm electromyogram signal, and the standard deviation reflects the degree of signal fluctuation. The preset significance level coefficient is used to control the sensitivity to changes in the diaphragm electromyogram signal. A larger significance level coefficient means that it will also respond to smaller changes in the diaphragm electromyogram signal. The time decay constant is used to control the weight decay rate of past diaphragm electromyogram signal data. The older the data, the smaller its impact on the current judgment. The time interval from the most recent sampling to the present can respond more quickly to new changes in the diaphragm electromyogram signal. Comparing the real-time diaphragm electromyogram signal with the dynamically adjusted judgment threshold, if the diaphragm electromyogram signal exceeds the threshold, it is determined that the patient has the intention of voluntary contraction, and thus the diaphragm stimulation is adjusted, such as increasing the stimulation intensity to assist breathing; if the diaphragm electromyogram signal is lower than the threshold, the stimulation intensity is reduced or the stimulation is paused.

[0069] In an alternative manner, the method further includes: after starting the diaphragm electrical stimulation, gradually increasing the current amplitude of the diaphragm electromyogram signal, where the increment calculation formula of the current amplitude is:

[0070]

[0071] where α is a scaling factor; β is a curve parameter; t is the current time; t ref is a reference time point; I max , I min are the maximum and minimum allowable values of the electrical stimulation current; I current is the current value of the electrical stimulation current; γ is a non-linear adjustment factor.

[0072] In this embodiment, constitutes an S-shaped curve, making the increment of the current continuous and smooth in time, and avoiding abrupt current changes. When the current value is close to the maximum value, the current increment will decrease to prevent over-stimulation.

[0073] In an alternative manner, the method further includes: after starting the diaphragm electrical stimulation, adjusting the frequency and pulse width of the diaphragm electromyogram signal, where the calculation formula of the frequency is:

[0074]

[0075] where f is the variable of the stimulation frequency; f min , f max respectively represent the minimum and maximum allowable values of the stimulation frequency; is the rate of voltage change; f critis the critical frequency; γ is the non - linear adjustment factor;

[0076] The calculation formula for the pulse width is as follows:

[0077]

[0078] where w is the variable of the pulse width; w min , w max respectively represent the minimum and maximum allowable values of the pulse width; η is the adjustment factor; w crit is the critical pulse width; δ is the non - linear adjustment factor.

[0079] In this embodiment, the critical frequency and the critical pulse width can be adjusted according to different patients or target tissues to achieve personalized stimulation. Introducing the voltage change rate enables the selection of both the frequency and the pulse width to consider the intensity of the stimulation, avoiding the risks of ineffective low - intensity stimulation or excessive high - intensity stimulation.

[0080] In an alternative way, the calculation of the preset frequency of the diaphragmatic electromyogram signal further includes:

[0081] Based on the patient's age, weight, and health status score, calculate the respiratory rate according to a preset empirical formula; where the preset empirical formula for the respiratory rate is:

[0082] RR = a·Age -b ·Weight c ·e d·HealthScore

[0083] where a, b, c, d are empirical coefficients; Age is the patient's age; Weight is the patient's weight; HealthScore is the patient's health status score;

[0084] Calculate the preset frequency according to the patient's respiratory rate, the difference between the current health status score and the baseline health status score; where the calculation formula for the preset frequency is:

[0085]

[0086] where HealthScore base is the baseline health status score; γ is the non - linear adjustment factor; ΔhealthScore is the difference between the current health status score and the baseline health status score.

[0087] In this embodiment, adjustment is made according to the difference between the current health status score and the baseline health status score, which can reflect the change of the patient's health status in real time and provide a more accurate respiratory rate setting. Among them, the baseline health status score represents the health score of the patient in a relatively stable and healthy state, and is a reference value used to measure the patient's initial health level or expected health level. Generally, the health status score when the patient is admitted to the hospital (or before receiving treatment) is taken as the baseline. If there is historical health data of the patient, the health score of the patient in a relatively healthy period or a period with better treatment effect can be taken as the baseline. If the patient has no historical data, the average health score of patients of the same age group or with similar conditions can also be used as a reference value. The current health status score represents the health score of the patient at the current moment and is updated in real time as the patient's health status changes. The health status of the patient can be scored through regular health assessments (including clinical examinations, vital sign monitoring, laboratory tests, patient complaints, etc.).

[0088] According to the solution provided by the present invention, a gastrointestinal tube provided with a plurality of electrodes is sent through the gastrointestinal tract to a position close to the diaphragm, and the electrodes are close to the diaphragm for collecting diaphragmatic electromyogram signals and amplifying the diaphragmatic electromyogram signals by 1000 to 5000 times through a differential amplifier; judging the presence of an autonomous contraction intention of the diaphragm according to the diaphragmatic electromyogram signal and triggering electrical stimulation; dynamically adjusting the diaphragmatic electromyogram signal according to the patient's respiratory response and the autonomous contraction intention; wherein, if diaphragmatic activity caused by electrical stimulation is not detected within a predetermined time, the current amplitude is gradually increased and the frequency and pulse width of the diaphragmatic electromyogram signal are adjusted to maximize the diaphragmatic contraction efficiency; if the diaphragmatic autonomous contraction signal is not detected within a predetermined time, rhythmic electrical stimulation with a preset frequency is started to prevent diaphragmatic disuse atrophy. The present invention dynamically adjusts the electrical stimulation parameters according to the patient's respiratory response and the autonomous contraction intention of the diaphragm, ensuring that the electrical stimulation occurs at the best time and under the best conditions, thereby improving the treatment effect.

[0089] Figure 2 The frame schematic diagram of the diaphragmatic electrical stimulation device according to the embodiment of the present invention is shown. The diaphragmatic electrical stimulation device includes:

[0090] A diaphragmatic electrical signal monitoring module 210, which is close to the diaphragm and includes a gastrointestinal tube provided with a plurality of electrodes. The gastrointestinal tube is sent through the gastrointestinal tract to a position close to the diaphragm, and the electrodes are close to the diaphragm for collecting diaphragmatic electromyogram signals and amplifying the diaphragmatic electromyogram signals by 1000 to 5000 times through a differential amplifier;

[0091] The electrical stimulation control module 220 is configured to determine whether there is an intention of voluntary contraction of the diaphragm and a respiratory response based on the diaphragmatic electromyogram signal to determine whether to trigger electrical stimulation; dynamically adjust the diaphragmatic electromyogram signal according to the patient's respiratory response and the intention of voluntary contraction; wherein, if the diaphragmatic electromyogram signal is not detected or the diaphragmatic electromyogram signal is weak and cannot cause a sufficient respiratory response within a predetermined time, electrical stimulation of the diaphragm is initiated to cause a sufficient respiratory response and prevent disuse atrophy of the diaphragm.

[0092] Figure 3 FIG. shows a schematic structural diagram of an embodiment of the computing device of the present invention. The specific embodiments of the present invention do not limit the specific implementation of the computing device.

[0093] As Figure 3 shown, the computing device may include: a processor 302, a communications interface 304, a memory 306, and a communication bus 308.

[0094] Wherein: the processor 302, the communications interface 304, and the memory 306 communicate with each other through the communication bus 308. The communications interface 304 is used to communicate with network elements of other devices such as clients or other servers. The processor 302 is configured to execute the program 310, and specifically may execute the relevant steps in the above-described embodiment of the method for electrical stimulation of the diaphragm.

[0095] Specifically, the program 310 may include program code, and the program code includes computer operation instructions.

[0096] The processor 302 may be a central processing unit CPU, or a specific integrated circuit ASIC (Application Specific Integrated Circuit), or one or more integrated circuits configured to implement the embodiments of the present invention. One or more processors included in the computing device may be of the same type of processor, such as one or more CPUs; or may be of different types of processors, such as one or more CPUs and one or more ASICs.

[0097] The memory 306 is used to store the program 310. The memory 306 may include high-speed RAM memory, and may also include non-volatile memory, such as at least one disk memory.

[0098] According to the solution provided by the present invention, a gastrointestinal tube with multiple electrodes is provided. The gastrointestinal tube is sent through the gastrointestinal tract to a position close to the diaphragm, and the electrodes are close to the diaphragm for collecting diaphragmatic electromyogram signals and amplifying the diaphragmatic electromyogram signals by 1000 to 5000 times through a differential amplifier; judging the existence of the autonomous contraction intention of the diaphragm according to the diaphragmatic electromyogram signals and triggering electrical stimulation; dynamically adjusting the diaphragmatic electromyogram signals according to the patient's respiratory response and the autonomous contraction intention; wherein, if diaphragmatic activity caused by electrical stimulation is not detected within a predetermined time, the current amplitude is gradually increased and the frequency and pulse width of the diaphragmatic electromyogram signals are adjusted to maximize the diaphragmatic contraction efficiency; if the diaphragmatic autonomous contraction signal is not detected within a predetermined time, rhythmic electrical stimulation with a preset frequency is started to prevent diaphragmatic disuse atrophy. The present invention dynamically adjusts the electrical stimulation parameters according to the patient's respiratory response and the autonomous contraction intention of the diaphragm, ensuring that the electrical stimulation occurs at the best time and under the best conditions, thereby improving the treatment effect.

[0099] Those skilled in the art can understand that the modules in the devices in the embodiments can be adaptively changed and arranged in one or more devices different from this embodiment. The modules or units or components in the embodiments can be combined into one module or unit or component, and in addition, they can be divided into multiple sub-modules or sub-units or sub-components. Except that at least some of such features and / or processes or units are mutually exclusive, any combination can be used to combine all the features disclosed in this specification (including the accompanying claims, abstract and drawings) and all the processes or units of any method or device so disclosed. Unless otherwise explicitly stated, each feature disclosed in this specification (including the accompanying claims, abstract and drawings) can be replaced by an alternative feature that provides the same, equivalent or similar purpose. In addition, those skilled in the art can understand that although some of the embodiments herein include certain features included in other embodiments but not other features, the combination of the features of different embodiments means that it is within the scope of the present invention and forms different embodiments. For example, in the following claims, any one of the claimed embodiments can be used in any combination. The present invention can be implemented by means of hardware including several different elements and by means of a properly programmed computer. In the unit claims listing several devices, several of these devices can be embodied by the same hardware item. The steps in the above embodiments, unless otherwise specified, should not be construed as a limitation on the execution order.

Claims

1. A method for electrical stimulation of the diaphragm, characterized in that: include: A gastrointestinal tube provided with multiple electrodes, the gastrointestinal tube is delivered to the stomach or small intestine via the gastrointestinal tract, the electrodes on the wall of the gastrointestinal tube are close to the diaphragm, and are used to collect diaphragm electromyographic signals and amplify the diaphragm electromyographic signals by 1000 to 5000 times through a differential amplifier; Judging whether the diaphragm has autonomous contraction intention and respiratory response based on the diaphragm electromyographic signal to determine whether to trigger electrical stimulation; dynamically adjusting the diaphragm electromyographic signal according to the patient's respiratory response and the autonomous contraction intention; wherein, if the diaphragm electromyographic signal is not detected within a predetermined time or the diaphragm electromyographic signal is too weak to induce sufficient respiratory response, diaphragm electrical stimulation is initiated to induce sufficient respiratory response and prevent disuse atrophy of the diaphragm.

2. The diaphragm electrical signal acquisition method according to claim 1, characterized in that: The collecting of diaphragm electromyographic signals and amplifying the diaphragm electromyographic signals by 1000 to 5000 times through a differential amplifier further comprises: Real-time measurement of the amplifier input voltage and output voltage; According to the preset gain coefficient, nonlinear adjustment factor and threshold voltage, the gain of the amplifier is dynamically adjusted to ensure that the diaphragm electromyographic signal is amplified to a range of 1000 to 5000 times; wherein the gain adjustment formula of the amplifier is: Where k is the gain coefficient; γ is the nonlinear adjustment factor; V thresh is the threshold voltage of the amplifier; V in Input voltage; V out is the output voltage.

3. The diaphragm electrical stimulation method according to claim 1, characterized in that: The method further comprises: The diaphragm electromyographic signal is dynamically adjusted according to the patient's respiratory response and the autonomous contraction intention; wherein, the judgment threshold is dynamically adjusted according to the mean and standard deviation of the diaphragm electromyographic signal in the most recent N sampling cycles; according to a preset significance level coefficient, a time decay constant and the time interval from the most recent sampling to the present; and the diaphragm electromyographic signal is adjusted according to the judgment threshold.

4. The diaphragm electrical stimulation method according to claim 1, characterized in that: The method further comprises: After starting the diaphragm electrical stimulation, the current amplitude of the diaphragm electromyographic signal is gradually increased, wherein the increment calculation formula of the current amplitude is: Among them, α is the scaling factor; β is the curve parameter; t is the current time; t ref is the reference time point; I max ,I min is the maximum and minimum permissible values ​​of the electrical stimulation current; I current is the current electrical stimulation current value; γ is the nonlinear adjustment factor.

5. The diaphragm electrical stimulation method according to claim 1, characterized in that: The method further comprises: After starting diaphragm electrical stimulation, the frequency and pulse width of the diaphragm electromyographic signal are adjusted, wherein the frequency is calculated as follows: Where, f is the variable of stimulation frequency; f min ,f max Respectively represent the minimum and maximum allowed values ​​of stimulation frequency; is the rate of voltage change; f crit is the critical frequency; γ is the nonlinear adjustment factor; The calculation formula of the pulse width is: Where, w is the variable of pulse width; w min ,w max They represent the minimum and maximum permissible values ​​of the pulse width respectively; η is the adjustment factor; w crit is the critical pulse width; δ is the nonlinear adjustment factor.

6. The diaphragm electrical stimulation method according to claim 1, characterized in that: The calculation of the preset frequency of the diaphragm electromyographic signal further includes: The respiratory rate is calculated based on the patient's age, weight, and health status score according to a preset empirical formula; the preset empirical formula for the respiratory rate is: RR=a·Age -b ·Weight c ·e d·HealthScore Among them, a, b, c, d are empirical coefficients; Age is the patient's age; Weight is the patient's weight; HealthScore is the patient's health status score; The preset frequency is calculated according to the patient's respiratory rate, the difference between the current health status score and the baseline health status score; wherein the calculation formula of the preset frequency is: Among them, HealthScore base is the baseline health score; γ is the nonlinear adjustment factor; ΔhealthScore is the difference between the current health score and the baseline health score.

7. The diaphragm electrical stimulation method according to claim 1, characterized in that: The distal end of the gastrointestinal tube is located in the stomach or small intestine; The plurality of electrodes are configured as a ring-shaped electrode array; The electrodes in the annular electrode array can be electrically stimulated individually or in groups.

8. The diaphragm electrical stimulation method according to claim 1, characterized in that: A plurality of electrode arrays are arranged on the wall of the gastrointestinal tube, the electrode arrays surround the wall of the gastrointestinal tube, and the electrode arrays are used to collect diaphragm electromyographic signals in different areas respectively; the electrode arrays are connected to an independent differential amplifier.

9. A diaphragm electrical stimulation device, characterized in that: include: A diaphragm electrical signal monitoring module, wherein a gastrointestinal tube is delivered to the stomach or small intestine via the gastrointestinal tract, and electrodes on the wall of the gastrointestinal tube are close to the diaphragm, and are used to collect diaphragm electromyographic signals and amplify the diaphragm electromyographic signals by 1000 to 5000 times through a differential amplifier; The electrical stimulation control module is used to determine whether the diaphragm has autonomous contraction intention and respiratory response based on the diaphragm electromyographic signal to determine whether to trigger electrical stimulation; dynamically adjust the diaphragm electromyographic signal according to the patient's respiratory response and the autonomous contraction intention; wherein, if the diaphragm electromyographic signal is not detected within a predetermined time or the diaphragm electromyographic signal is weak and cannot cause sufficient respiratory response, then start diaphragm electrical stimulation to cause sufficient respiratory response to prevent disuse atrophy of the diaphragm.

10. A computing device comprising: A processor, a memory, a communication interface and a communication bus, wherein the processor, the memory and the communication interface communicate with each other via the communication bus; The memory is used to store at least one executable instruction, and the executable instruction enables the processor to execute operations corresponding to the above-mentioned diaphragm electrical stimulation method.

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