Newborn jaundice-removing medicated bath soup as well as preparation method and application thereof

Abstract

The invention provides a neonatal jaundice-removing medicated bath soup and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparation, the neonatal jaundice-removing medicated bath soup is prepared from the following raw materials: oriental wormwood, radix bupleuri, cape jasmine, salvia miltiorrhiza, rheum officinale, schizonepeta spike, divaricate saposhnikovia root, belvedere fruit and liquorice. The preparation method comprises the following steps: (1) mixing oriental wormwood, radix bupleuri, cape jasmine, salvia miltiorrhiza, rheum officinale, schizonepeta spike, divaricate saposhnikovia root, fructus kochiae and liquorice to obtain a mixture; and (2) grinding the mixture into fine residues by using a traditional Chinese medicine grinder, filling the fine residues into a non-woven bag, adding water, decocting, filtering, and removing filter residues to obtain the medicated bath soup. The medicated bath soup disclosed by the invention not only can prevent jaundice, but also can effectively treat jaundice, and has a very remarkable curative effect on neonatal eczema.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparation, and particularly relates to a medicated bath soup for relieving jaundice in newborns, a preparation method thereof, and an application thereof. Background Art

[0002] Neonatal jaundice refers to the phenomenon that due to abnormal bilirubin metabolism during the neonatal period, the bilirubin level in the blood increases, resulting in yellowing of the skin and mucous membranes. It may be a symptom that appears during the normal development process or a manifestation of certain diseases. In severe cases, it can cause brain damage or even death. Currently, the international diagnosis of neonatal jaundice no longer emphasizes determining whether neonatal jaundice is physiological or pathological, but pays more attention to the early intervention of jaundice. Blue light irradiation is currently the internationally recognized method for treating hyperbilirubinemia. Through blue light irradiation, bilirubin is transformed from a lipid-soluble state to a water-soluble state, and without going through the conjugation in the liver, it is excreted out of the body through bile or urine. Taking a baby for blue light irradiation is very troublesome. Medicated bath with traditional Chinese medicine dissolves traditional Chinese medicine in water, enabling the medicine to directly act on the meridians and blood vessels through the skin, acupoints, etc., and distributing throughout the body, having the effects of promoting blood circulation and qi movement, clearing heat and detoxifying, and warming and dredging the meridians. By absorbing the effective components of the drugs for promoting diuresis and relieving jaundice, the excretion of bilirubin is accelerated, the subsidence of neonatal jaundice is accelerated, the course of disease is shortened, and it is safe and effective.

[0003] The history of medicated bath is long and has a history of more than 3,000 years of application. The external washing formula of traditional Chinese medicine for relieving jaundice is prepared based on the classic prescriptions for treating jaundice recorded in traditional Chinese medicine ancient books such as "Treatise on Febrile Diseases of the Lung" and "Complete Works of Jingyue. Jaundice" and the characteristics of neonatal jaundice, and is formulated through repeated demonstration and practice by traditional Chinese medicine clinical experts. It has been clinically proven to have the characteristics of quick onset, simplicity and easy operation, high safety, and few side effects. Due to the tender and thin skin and large body surface area of newborns, the medicine is easily permeated through the skin into the capillaries, thereby promoting blood circulation and achieving the effect of promoting diuresis and relieving jaundice. At the same time, the combination of medicated bath with traditional Chinese medicine and an Ai salt pack can also promote the gastrointestinal peristalsis of newborns, increase defecation, reduce bilirubin, and promote the enterohepatic circulation, and can relieve the symptoms of jaundice.

[0004] In addition, neonatal medicated bath can improve the immunity of infants, improve various skin problems, avoid the irritation of neonatal infusion treatment and oral drugs to the oral mucosa and digestive tract of newborns, and also avoid the side effects of drugs directly entering the systemic circulation on organs such as the liver and kidneys. Medicated bath hydrotherapy belongs to external treatment methods, and there is no pain during the treatment, which is especially suitable for newborns. Summary of the Invention

[0005] The purpose of the present invention is to provide a medicated bath soup for relieving jaundice in newborns, a preparation method thereof, and an application thereof, which have good effects in preventing and treating neonatal jaundice and treating neonatal eczema.

[0006] The technical solution of the present invention is realized as follows: The present invention provides a medicinal bath decoction for reducing jaundice in newborns, which is prepared from the following raw materials: Artemisia capillaris Thunb., Bupleurum chinense DC., Gardenia jasminoides Ellis, Salvia miltiorrhiza Bunge, Rheum palmatum L., Schizonepeta tenuifolia Briq., Saposhnikovia divaricata (Turcz.) Schischk., Kochia scoparia (L.) Schrad., and Glycyrrhiza uralensis Fisch.

[0007] As a further improvement of the present invention, it is prepared from the following raw materials in parts by weight: 20-30 parts of Artemisia capillaris Thunb., 10-12 parts of Bupleurum chinense DC., 10-15 parts of Gardenia jasminoides Ellis, 20-30 parts of Salvia miltiorrhiza Bunge, 8-10 parts of Rheum palmatum L., 10-12 parts of Schizonepeta tenuifolia Briq., 6-9 parts of Saposhnikovia divaricata (Turcz.) Schischk., 10-15 parts of Kochia scoparia (L.) Schrad., and 6-9 parts of Glycyrrhiza uralensis Fisch.

[0008] As a further improvement of the present invention, it is prepared from the following raw materials in parts by weight: 24-28 parts of Artemisia capillaris Thunb., 10-11 parts of Bupleurum chinense DC., 12-14 parts of Gardenia jasminoides Ellis, 24-28 parts of Salvia miltiorrhiza Bunge, 8-9 parts of Rheum palmatum L., 10-11 parts of Schizonepeta tenuifolia Briq., 6-8 parts of Saposhnikovia divaricata (Turcz.) Schischk., 12-14 parts of Kochia scoparia (L.) Schrad., and 6-8 parts of Glycyrrhiza uralensis Fisch.

[0009] As a further improvement of the present invention, it is prepared from the following raw materials in parts by weight: 25 parts of Artemisia capillaris Thunb., 10 parts of Bupleurum chinense DC., 13 parts of Gardenia jasminoides Ellis, 25 parts of Salvia miltiorrhiza Bunge, 8 parts of Rheum palmatum L., 10 parts of Schizonepeta tenuifolia Briq., 7 parts of Saposhnikovia divaricata (Turcz.) Schischk., 13 parts of Kochia scoparia (L.) Schrad., and 7 parts of Glycyrrhiza uralensis Fisch.

[0010] The present invention further protects a preparation method of the medicinal bath decoction for reducing jaundice in newborns, which comprises the following steps: (1) Mix Artemisia capillaris Thunb., Bupleurum chinense DC., Gardenia jasminoides Ellis, Salvia miltiorrhiza Bunge, Rheum palmatum L., Schizonepeta tenuifolia Briq., Saposhnikovia divaricata (Turcz.) Schischk., Kochia scoparia (L.) Schrad., and Glycyrrhiza uralensis Fisch. to obtain a mixture; (2) Grind the above mixture into fine residues with a traditional Chinese medicine grinder, put it into a non-woven bag, add water, boil, filter, and remove the filter residues to obtain the medicinal bath decoction.

[0011] As a further improvement of the present invention, the mass of the added water is 6-10 times the mass of the mixture As a further improvement of the present invention, the boiling time is 30-60 min.

[0012] The present invention further protects the application of the medicinal bath decoction for reducing jaundice in newborns in the preparation of drugs for preventing and treating neonatal jaundice.

[0013] As a further improvement of the present invention, in the above application, the medicinal bath decoction needs to be placed in 5-10 times the volume of clear water, and the newborn is bathed in the decoction for 15-20 min.

[0014] The present invention further protects the application of the medicinal bath decoction for reducing jaundice in newborns in the preparation of drugs for treating neonatal eczema.

[0015] The present invention has the following beneficial effects: Artemisia capillaris, Bupleurum chinense, and Gardenia jasminoides are the principal drugs, which soothe the liver, promote bile secretion, remove dampness, and relieve jaundice. Salvia miltiorrhiza and Rheum palmatum are the secondary drugs, which cool the blood, dispel stasis, and assist the principal drugs. Schizonepeta tenuifolia, Saposhnikovia divaricata, and Kochia scoparia are the adjuvant drugs, which dispel wind and relieve itching. Glycyrrhiza uralensis is the guiding drug, which harmonizes all the drugs. This prescription together exerts the effects of promoting bile secretion and relieving jaundice, clearing heat and detoxifying, regulating the physique, and dispelling wind and relieving itching. The skin of newborns is relatively delicate. The method of traditional Chinese medicine medicated bath can enable the skin of the child to come into extensive contact with the drugs. Through transdermal administration through the skin, meridians, acupoints, etc., it can promote the body metabolism and blood circulation of the child, accelerate the drug absorption, and play the role of external treatment for internal disease treatment. Detailed implementation mode

[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Apparently, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0017] Embodiment 1 Preparation method of medicated bath soup for newborns to relieve jaundice Artemisia capillaris 25 g, Bupleurum chinense 10 g, Gardenia jasminoides 13 g, Salvia miltiorrhiza 25 g, Rheum palmatum 8 g, Schizonepeta tenuifolia 10 g, Saposhnikovia divaricata 7 g, Kochia scoparia 13 g, Glycyrrhiza uralensis 7 g.

[0018] Mix the above nine herbs, grind them into fine residues with a traditional Chinese medicine grinder, put them into a non-woven cloth bag, add 708 g of water, boil for 30 min, filter, remove the filter residues, and obtain the medicated bath soup. Embodiment 2 Preparation method of medicated bath soup for newborns to relieve jaundice Artemisia capillaris 20 g, Bupleurum chinense 10 g, Gardenia jasminoides 10 g, Salvia miltiorrhiza 20 g, Rheum palmatum 8 g, Schizonepeta tenuifolia 10 g, Saposhnikovia divaricata 6 g, Kochia scoparia 10 g, Glycyrrhiza uralensis 6 g.

[0019] Mix the above nine herbs, grind them into fine residues with a traditional Chinese medicine grinder, put them into a non-woven cloth bag, add 1000 g of water, boil for 60 min, filter, remove the filter residues, and obtain the medicated bath soup. Embodiment 3 Preparation method of medicated bath soup for newborns to relieve jaundice Artemisia capillaris 28 g, Bupleurum chinense 11 g, Gardenia jasminoides 14 g, Salvia miltiorrhiza 28 g, Rheum palmatum 9 g, Schizonepeta tenuifolia 11 g, Saposhnikovia divaricata 8 g, Kochia scoparia 14 g, Glycyrrhiza uralensis 8 g.

[0020] Mix the above nine herbs, grind them into fine residues with a traditional Chinese medicine grinder, put them into a non-woven cloth bag, add 1000 g of water, boil for 60 min, filter, remove the filter residues, and obtain the medicated bath soup.

[0021] Embodiment 4 Preparation method of medicated bath soup for newborns to relieve jaundice 30 g of Artemisia scoparia, 12 g of Bupleurum chinense, 15 g of Gardenia jasminoides, 30 g of Salvia miltiorrhiza, 10 g of Rheum palmatum, 12 g of Schizonepeta tenuifolia, 9 g of Saposhnikovia divaricata, 15 g of Kochia scoparia, 9 g of Glycyrrhiza uralensis.

[0022] The above nine herbs are mixed, ground into fine residues with a traditional Chinese medicine grinder, put into a non-woven cloth bag, added with 1000 g of water, boiled for 60 min, filtered, and the filter residues are removed to obtain a medicated bath soup. Example 5 Clinical study of the jaundice-relieving medicated bath soup for newborn infants Control group: The infants were treated with double-sided phototherapy in an infant incubator, with intermittent blue light irradiation. The eyes were covered with blue light eye masks and the infants wore blue light diapers, and the rest of the body was exposed to receive light. During the treatment, the skin of the infants was evenly irradiated with light for 6 - 8 h every day.

[0023] Treatment group: On the basis of the control group, the medicated bath soup of Example 1 was used, added to 5000 ml of water, and the temperature was adjusted to about 37°C. Newborn infants were bathed in the decoction for 20 min and showered once a day.

[0024] The treatment time for both the control group and the treatment group was 5 days, and the changes in the serum total bilirubin values (TSB) of the two groups of infants before and after treatment were recorded.

[0025]

[0026] As can be seen from Table 1, the effective rate of the control group was 85%, and the total effective rate of the treatment group was 97.5%. The total effective rate of the treatment group was higher than that of the control group, and the difference between the two groups was statistically significant (P < 0.05). Cure: After treatment, the TSB value < 85.5 μmol / L (5 mg / dl), and the jaundice of the skin and face completely subsided; Marked effect: After treatment, the decrease amplitude of the TSB value compared with that before treatment > 60%, and the symptoms and signs such as jaundice of the skin and face improved significantly; Effective: After treatment, the decrease amplitude of the TSB value compared with that before treatment > 25%, and the symptoms and signs such as jaundice of the skin and face improved slightly; Ineffective: After treatment, the TSB value did not decrease or even increased, and the symptoms and signs such as jaundice of the skin and face did not improve or even worsened. It can be seen that on the basis of Western medicine treatment (phototherapy), the auxiliary treatment with the jaundice-relieving medicated bath soup of the present invention has a significant effect on clearing serum bilirubin compared with Western medicine treatment (phototherapy) for jaundice relief.

[0027] i. Source of cases: Inpatients in the Second People's Hospital of Lanzhou City; ii. Traditional Chinese medicine diagnostic criteria The clinical manifestations are deep jaundice, jaundice of the whole body skin and mucosa, jaundice of the whole body skin, etc.; iii. Age: Born 1 - 6 days.

[0028] Male, 3 days old.

[0029] Chief complaint: Jaundice of the whole body skin for 1 day; History of present illness: The family members of the child reported that the child developed jaundice of the skin and mucous membranes 1 day after birth, and no other discomfort was reported.

[0030] Past history: The child had been in good health.

[0031] Physical examination: All vital signs were stable, and the skin and mucous membranes were slightly jaundiced.

[0032] Initial diagnosis: Neonatal jaundice Suggested examination: Transcutaneous bilirubinometry in neonates (at three sites) Treatment advice: Neonatal medicated bath (using the medicated bath soup in Example 1, adding it to 5000 ml of water, adjusting the temperature to about 37°C, and the newborn child takes a bath in the decoction for 20 minutes, once a day.) Symptoms on admission: Transcutaneous bilirubinometry in neonates (at three sites): 12.6 / 14.0 / 14.0 mg / dl; Symptoms on the third day of admission: Transcutaneous bilirubinometry in neonates (at three sites): 9.1 / 11.2 / 9.0 mg / dl, and the skin and mucous membranes of the newborn improved compared with before.

[0033] Male, 1 day old.

[0034] Chief complaint: Generalized skin jaundice for half a day; History of present illness: The family members of the child reported that the child developed jaundice of the skin and mucous membranes half a day after birth, and no other discomfort was reported. Transcutaneous bilirubinometry in neonates (at three sites): 7.9 / 7.3 / 10.2 mg / dl; Past history: The child had been in good health.

[0035] Physical examination: All vital signs were stable, and the skin and mucous membranes were slightly jaundiced.

[0036] Initial diagnosis: Neonatal jaundice Suggested examination: Transcutaneous bilirubinometry in neonates (at three sites) Treatment advice: Neonatal medicated bath (using the medicated bath soup in Example 1, adding it to 5000 ml of water, adjusting the temperature to about 37°C, and the newborn child takes a bath in the decoction for 20 minutes, once a day.) Symptoms on the third day of admission: Transcutaneous bilirubinometry in neonates (at three sites): 7.0 / 7.3 / 9.0 mg / dl, and the skin jaundice improved compared with before.

[0037] Female, 2 days old.

[0038] Chief complaint: Generalized skin and mucous membrane jaundice for 2 days; History of present illness: The family members of the child reported that the child developed jaundice of the skin and mucous membranes 2 days after birth, and no other discomfort was reported. Transcutaneous bilirubinometry in neonates (at three sites): 11.8 / 14.4 / 14.1 mg / dl; Past medical history: Healthy

[0039] Physical examination: All vital signs are stable, and the skin and mucous membranes of the whole body are slightly jaundiced

[0040] Initial diagnosis: Neonatal jaundice Suggested examination: Transcutaneous bilirubinometry in neonates (at three sites) Treatment advice: Neonatal medicated bath (using the medicated bath soup in Example 1, adding it to 5000 ml of water, adjusting the temperature to about 37°C, and the neonate takes a bath in the decoction for 20 minutes, once a day) Symptoms on the fourth day of admission: Transcutaneous bilirubinometry in neonates (at three sites): 9.7 / 7.7 / 7.8 mg / dl, and the skin jaundice has improved compared to before The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention

Claims

1. A medicinal bath soup for relieving jaundice in newborns, characterized in that: It is prepared from the following raw materials: Artemisia capillaris, bupleurum, gardenia, salvia miltiorrhiza, rhubarb, schizonepeta spicate, siler, kochia scoparia, and liquorice.

2. The medicinal bath soup for relieving jaundice in newborns according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 20-30 parts of Artemisia capillaris, 10-12 parts of Bupleurum chinense, 10-15 parts of Gardenia jasminoides, 20-30 parts of Salvia miltiorrhiza, 8-10 parts of Rhubarb, 10-12 parts of Schizonepeta spicate, 6-9 parts of Saposhnikovia divaricata, 10-15 parts of Kochia scoparia and 6-9 parts of Licorice.

3. The medicinal bath soup for relieving jaundice in newborns according to claim 2, characterized in that: The invention is prepared from the following raw materials in parts by weight: 24-28 parts of Artemisia capillaris, 10-11 parts of Bupleurum chinense, 12-14 parts of Gardenia jasminoides, 24-28 parts of Salvia miltiorrhiza, 8-9 parts of Rhubarb, 10-11 parts of Schizonepeta spicate, 6-8 parts of Saposhnikovia divaricata, 12-14 parts of Kochia scoparia and 6-8 parts of Licorice.

4. The medicinal bath soup for relieving jaundice in newborns according to claim 3, characterized in that: The invention is prepared from the following raw materials in parts by weight: 25 parts of Artemisia capillaris, 10 parts of Bupleurum chinense, 13 parts of Gardenia jasminoides, 25 parts of Salvia miltiorrhiza, 8 parts of Rhubarb, 10 parts of Schizonepeta spicate, 7 parts of Saposhnikovia divaricata, 13 parts of Kochia scoparia and 7 parts of Licorice.

5. A method for preparing the jaundice-reducing medicinal bath soup for newborns as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Mix Artemisia capillaris, Bupleurum root, Gardenia jasminoides, Salvia miltiorrhiza, Rhubarb, Schizonepeta spicate, Saposhnikovia divaricata, Kochia scoparia, and Licorice root to obtain a mixture; (2) Grind the mixture into fine residue using a Chinese medicine grinder, put it into a non-woven bag, add water, boil it, filter it, remove the residue, and obtain a medicinal bath soup.

6. The preparation method according to claim 5, characterized in that: The mass of water added is 6-10 times the mass of the mixture.

7. The preparation method according to claim 5, characterized in that: The cooking time is 30-60 minutes.

8. Use of the neonatal jaundice-reducing medicinal bath soup as claimed in any one of claims 1 to 4 in the preparation of medicines for preventing and treating neonatal jaundice.

9. The use according to claim 8, characterized in that: In the application, the medicinal bath soup needs to be placed in 5-10 times the volume of clean water, and the newborn baby bathes in the soup for 15-20 minutes.

10. Use of the neonatal jaundice-reducing medicinal bath soup as claimed in any one of claims 1 to 4 in the preparation of medicines for treating neonatal eczema.

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