Synthesis method of polysulfone group segmented copolymer

Abstract

The invention discloses a synthesis method of a polysulfone group segmented copolymer, which comprises the following steps: (a) in a nitrogen or argon atmosphere, adding an aromatic diphenol monomer, an aromatic dihalogenated compound monomer, a salt-forming agent, an organic solvent and a water-carrying agent into a reaction kettle, heating at 100-150 DEG C to form salt and dehydrate for 1-24 hours, then raising the temperature to 160-250 DEG C, and carrying out high-temperature polymerization reaction for 1-10 hours; (b) under the system in the step (a), reducing the temperature of the reaction kettle to 100-150 DEG C, adding a hydrophilic material, and reacting for 1-6 hours to obtain a reaction material liquid; the hydrophilic material is polyoxazoline or a derivative thereof; and (c) cooling, filtering, precipitating in water, cleaning and drying the reaction material liquid to obtain the polysulfone group segmented copolymer. By controlling the feeding mode, the molecular weight and the feeding ratio of the hydrophilic material, the block copolymers with different molecular weights are synthesized, and the polysulfone group block copolymers can be applied to the fields of biology, medical treatment, mechanical manufacturing, aviation, automobiles, petrochemical engineering, electronic information, membrane separation and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of polymer materials, and particularly to a method for synthesizing a polysulfone-based block copolymer. Background Art

[0002] Polysulfone-based polymer materials are traditional engineering plastics, which have excellent thermal stability, chemical stability, mechanical strength, oxidation resistance, etc., are easy to process and form, and are widely used in the fields of membrane separation, medical treatment, mechanical manufacturing, electronic industry, etc. Polysulfone-based materials are often used in the research and production of separation materials such as microfiltration, ultrafiltration or nanofiltration membranes for water treatment and material separation. However, due to the molecular chain rigidity and hydrophobicity of polysulfone-based materials themselves, the prepared separation membranes have problems such as low flux, poor anti-pollution ability, and short service life, which restrict their application space.

[0003] In order to improve the separation performance and anti-pollution performance of the membrane, preparing a separation membrane by blending a hydrophilic material with a polysulfone-based material is a relatively simple and effective method at present. Chinese Patent CN117098593A discloses an asymmetric membrane, in which polyethersulfone and poly(2-ethyl-2-oxazoline) are blended to prepare a separation membrane. The prepared separation membrane has excellent anti-protein adsorption ability and good anti-pollution performance, improving the separation efficiency and service life of the membrane. However, in the process of using the anti-pollution separation membrane prepared by blending a hydrophilic material into the separation membrane, the hydrophilic material will gradually lose, resulting in the continuous deterioration of the separation membrane performance and the pollution of the feed solution. To endow the polysulfone-based separation membrane with long-term stable permeation selectivity and anti-pollution performance, research scholars have developed amphiphilic polysulfone-based block copolymer membrane materials, introducing hydrophilic materials such as hydrophilic polyethylene glycol (PEG) and polyglycidol into the end of the polysulfone-based material through chemical bonds to improve the hydrophilicity of the polysulfone-based material and use it for membrane preparation. Chinese Patent CN115873259A discloses a synthesis method of a polyethersulfone block copolymer material. First, polyethersulfone is synthesized, and then polyethylene glycol is added to synthesize PES- b -PEG. The synthesized block copolymer is applied to the field of separation membranes. The prepared separation membrane has good mechanical properties and excellent separation performance, but the anti-pollution performance has not been significantly improved, restricting its application in the field of separation membranes. Summary of the Invention

[0004] The object of the present invention is to provide a method for synthesizing a polysulfone-based block copolymer to solve the problem of poor anti-pollution performance of the polyethersulfone block copolymer material as a separation membrane.

[0005] To achieve the above object, the first aspect of the present invention provides a method for synthesizing a polysulfone-based block copolymer, including the following steps: (a) Under a nitrogen or argon atmosphere, an aromatic diol monomer, an aromatic dihalide monomer, a salt-forming agent, an organic solvent, and a water-carrying agent are added to a reaction kettle, and salt formation and dehydration are carried out by heating at 100-150 °C for 1-24 h, and then the temperature is raised to 160-250 °C for high-temperature polymerization reaction for 1-10 h; (b) Under the system of (a) above, after the temperature of the reaction kettle is lowered to 100-150 °C, a hydrophilic material is added and reacted for 1-6 h to obtain a reaction feed liquid; the hydrophilic material is polyoxazoline or its derivative; (c) After the above reaction feed liquid is subjected to cooling filtration, precipitation in water, and washing and drying, a polysulfone-based block copolymer is obtained.

[0006] Preferably, in step (a), the aromatic diol monomer is one or more of bisphenol A, bisphenol S, biphenol, hydroquinone, 4,4'-dihydroxybiphenyl, 4,4'-dihydroxydiphenyl ether, 4,4'-dihydroxydiphenyl sulfide, 4,4'-dihydroxydiphenylmethane, 3,3'-dihydroxydiphenylamine, 2,2'-dihydroxybiphenyl, 2,2'-dihydroxydiphenylmethane, 2,6'-dihydroxynaphthalene, 2,7'-dihydroxynaphthalene.

[0007] Preferably, in step (a), the aromatic dihalide monomer is one or more of p-fluorodiphenyl sulfone, p-chlorodiphenyl sulfone, p-bromodiphenyl sulfone, 4,4'-difluorobenzophenone, 4,4'-dichlorobenzophenone.

[0008] Preferably, in step (a), the salt-forming agent is one or more of potassium carbonate, sodium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride, potassium hydride, metallic sodium, lithium diisopropylamide, lithium bis(trimethylsilyl)amide, sodium bis(trimethylsilyl)amide.

[0009] Preferably, in step (a), the organic solvent is one or more of N,N-dimethylacetamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, sulfolane.

[0010] Preferably, in step (a), the water-carrying agent is one or more of benzene, toluene, xylene, chlorobenzene, ethylbenzene, mesitylene, pyridine, cyclohexane.

[0011] Preferably, the molar ratio of the aromatic diol monomer, the aromatic dihalide monomer, the salt-forming agent, and polyoxazoline or its derivative is 1:(0.8-1.2):(1-6):(0.001-1); wherein the organic solvent required for each mole of the aromatic diol monomer is 0.2-3 L, and the water-carrying agent required is 0.1-2 L.

[0012] Preferably, in step (b), the hydrophilic material is one or more of poly(2-methyl-2-oxazoline), poly(2-ethyl-2-oxazoline), poly(2-isopropyl-2-oxazoline), poly(2-butyl-2-oxazoline), and poly(2-phenyl-2-oxazoline).

[0013] Preferably, the hydrophilic material is poly(2-ethyl-2-oxazoline).

[0014] The second aspect of the present invention provides the application of the polysulfone-based block copolymer prepared by the above synthesis method in the fields of biology, medicine, pharmacy, semiconductor, environmental protection, and membrane separation.

[0015] Preferably, for the application of the polysulfone-based block copolymer in the field of membrane separation, after the polysulfone-based block copolymer is made into a separation membrane, the BSA protein adsorption amount is less than 35 ug / cm 2 , the pure water permeability coefficient is greater than 2000 LMH / bar, and the BSA rejection rate is greater than 95%.

[0016] Therefore, the synthesis method of a polysulfone-based block copolymer of the present invention has the following beneficial effects: (1) The present invention adopts a brand-new synthesis process. By controlling the feeding mode, molecular weight, and feeding ratio of the hydrophilic material, polysulfone-based block copolymers with different molecular weights are synthesized, thereby increasing the molecular weight of the polysulfone-based block copolymer.

[0017] (2) The polysulfone-based block copolymer prepared by the present invention has a wide range of applications and can be applied to the fields of biology, medicine, mechanical manufacturing, aviation, automobile, petrochemical industry, electronic information, membrane separation, etc. Especially for the application of the polysulfone-based block copolymer in the field of membrane separation, after the polysulfone-based block copolymer is made into a separation membrane, the BSA protein adsorption amount is less than 35 ug / cm 2 , the pure water permeability coefficient is greater than 2000 LMH / bar, and the BSA rejection rate is greater than 95%. After the polysulfone-based block copolymer is made into a separation membrane, it takes into account both the water flux and anti-pollution performance of the separation membrane.

[0018] (3) When the synthesis method of the present invention prepares the polysulfone-based block copolymer material, the production cycle is short, the obtained material has a high molecular weight and stable performance, and is suitable for industrial scale-up.

[0019] Next, through examples, the technical solutions of the present invention will be further described in detail. Detailed Embodiments

[0020] The following will further describe the present invention. It should be noted that this embodiment is based on the present technical solution, and detailed implementation manners and specific operation processes are given, but the present invention is not limited to this embodiment.

[0021] Example 1 A method for synthesizing a polysulfone-based block copolymer, comprising the following steps: Add 0.1 mol of bisphenol S and 0.2 mol of KOH into a four-necked flask, perform Schlenk operation on the system to make the system in an inert gas atmosphere, add 150 mL of sulfolane and 140 mL of xylene to the system, and adjust the system temperature to 162 °C for a 5-hour water removal reaction.

[0022] After the water removal is completed, discharge the xylene in the system, add 0.1 mol of p-chlorodiphenyl sulfone to the system, adjust the system temperature to 235 °C and react for 5 h, then lower the system temperature to 140 °C, add 0.0035 mol of poly(2-ethyl-2-oxazoline) with a molecular weight of 2000 Da, continue to react for 2 h, filter the reaction stock solution with a polytetrafluoroethylene filter membrane with a pore size of 5 μm, then settle the filtered reaction stock solution in pure water to obtain solid particles, add a certain amount of hydrochloric acid and wash repeatedly until the pH is neutral, and finally place the obtained solid substance in an oven at 60 °C and dry it thoroughly to obtain the required material. The content of hydrophilic chain segments in the obtained material is 8% by thermogravimetric test.

[0023] Example 2 A method for synthesizing a polysulfone-based block copolymer, comprising the following steps: Add 0.1 mol of bisphenol S and 0.2 mol of KOH into a four-necked flask, perform Schlenk operation on the system to make the system in an inert gas atmosphere, add 150 mL of sulfolane to the system, and react at 110 °C for 24 h. After the reaction is completed, add 0.1 mol of p-chlorodiphenyl sulfone and 140 mL of xylene to the system, and adjust the system temperature to 162 °C for a 2-hour water removal reaction.

[0024] After the water removal is completed, discharge the xylene in the system, adjust the system temperature to 208 °C and react for 7 h, then lower the system temperature to 140 °C, add 0.0035 mol of poly(2-ethyl-2-oxazoline) with a molecular weight of 2000 Da, continue to react for 2 h, filter the reaction stock solution with a polytetrafluoroethylene filter membrane with a pore size of 5 μm, then settle the filtered reaction stock solution in pure water to obtain solid particles, add a certain amount of hydrochloric acid and wash repeatedly until the pH is neutral, and finally place the obtained solid substance in an oven at 60 °C and dry it thoroughly to obtain the required material. The content of hydrophilic chain segments in the obtained material is 13% by thermogravimetric test.

[0025] Example 3 A method for synthesizing a polysulfone-based block copolymer, comprising the following steps: Add 0.1 mol of bisphenol S, 0.2 mol of KOH, and 0.005 mol of potassium carbonate into a four-necked flask. Perform Schlenk operation on the system to make the system in an inert gas atmosphere. After adding 150 mL of sulfolane to the system, react at 110 °C for 24 h. After the reaction is completed, add 0.1 mol of p-chlorodiphenyl sulfone and 140 mL of toluene to the system, and adjust the system temperature to 140 °C for a 5-h water removal reaction.

[0026] After the water removal is completed, discharge the xylene in the system. After adjusting the system temperature to 208 °C and reacting for 5 h, lower the system temperature to 140 °C, add 0.0035 mol of poly(2-ethyl-2-oxazoline) with a molecular weight of 2000 Da, continue the reaction for 2 h, filter the reaction feed liquid with a polytetrafluoroethylene filter membrane with a pore size of 5 μm, then settle the filtered reaction feed liquid in pure water to obtain solid particles, add a certain amount of hydrochloric acid and wash repeatedly until the pH is neutral. Finally, place the obtained solid substance in an oven at 60 °C and dry it thoroughly to obtain the required material. The hydrophilic segment content in the obtained material by thermogravimetric test is 10%.

[0027] Example 4 A method for synthesizing a polysulfone-based block copolymer, comprising the following steps: Add 0.1 mol of bisphenol A, 0.1 mol of p-chlorodiphenyl sulfone, and 0.2 mol of potassium carbonate into a four-necked flask. Perform Schlenk operation on the system to make the system in an inert gas atmosphere. Add 150 mL of N,N-dimethylacetamide and 140 mL of toluene to the system, and adjust the system temperature to 138 °C for a 12-h water removal reaction.

[0028] After the water removal is completed, discharge the toluene in the system. After adjusting the system temperature to 160 °C and reacting for 7.5 h, lower the system temperature to 150 °C, add 0.0035 mol of poly(2-ethyl-2-oxazoline) with a molecular weight of 2000 Da, continue the reaction for 2 h, filter the reaction feed liquid with a polytetrafluoroethylene filter membrane with a pore size of 5 μm, then settle the filtered reaction feed liquid in pure water to obtain solid particles, add a certain amount of hydrochloric acid and wash repeatedly until the pH is neutral. Finally, place the obtained solid substance in an oven at 60 °C and dry it thoroughly to obtain the required material.

[0029] Example 5 A method for synthesizing a polysulfone-based block copolymer, comprising the following steps: Add 0.1 mol of bisphenol A, 0.1 mol of p-chlorodiphenyl sulfone and 0.3 mol of potassium carbonate into a four-necked flask. Conduct Schlenk operation on the system to make the system in an inert gas atmosphere. Add 150 mL of N,N-dimethylacetamide and 140 mL of toluene into the system. Adjust the temperature of the system to 138 °C and carry out a water removal reaction for 12 h.

[0030] After the water removal is completed, drain the toluene in the system. Adjust the temperature of the system to 160 °C and react for 7.5 h. Then, lower the temperature of the system to 150 °C, add 0.0035 mol of poly(2-ethyl-2-oxazoline) with a molecular weight of 2000 Da, continue the reaction for 2 h. Then, filter the reaction feed liquid with a polytetrafluoroethylene filter membrane with a pore size of 5 μm. Then, precipitate the filtered reaction feed liquid into pure water to obtain solid particles. Add a certain amount of hydrochloric acid and wash repeatedly until the pH is neutral. Finally, place the obtained solid substance in an oven at 60 °C and dry it thoroughly to obtain the required material.

[0031] Example 6 The difference between this example and Example 1 lies in the hydrophilic material. In this comparative example, the poly(2-ethyl-2-oxazoline) in Example 1 is replaced by poly(2-methyl-2-oxazoline).

[0032] Example 7 The difference between this example and Example 1 lies in the hydrophilic material. In this comparative example, the poly(2-ethyl-2-oxazoline) in Example 1 is replaced by poly(2-isopropyl-2-oxazoline).

[0033] Example 8 The difference between this example and Example 1 lies in the hydrophilic material. In this comparative example, the poly(2-ethyl-2-oxazoline) in Example 1 is replaced by poly(2-phenyl-2-oxazoline).

[0034] Example 9 The difference between this example and Example 1 lies in the hydrophilic material. In this comparative example, the poly(2-ethyl-2-oxazoline) in Example 1 is replaced by poly(2-butyl-2-oxazoline).

[0035] Comparative Example 1 The difference between this comparative example and Example 1 lies in the hydrophilic material. In this comparative example, the poly(2-ethyl-2-oxazoline) in Example 1 is replaced by polyethylene glycol.

[0036] Test Example Test the properties of the polysulfone-based block copolymers prepared in the examples and comparative examples, and compare them with commercial PES membranes.

[0037] (1) The polysulfone-based block copolymer prepared in the examples was made into an ultrafiltration membrane. The specific preparation process is as follows: First, the polysulfone-based block copolymer was dissolved in a certain amount of DMSO solvent. It was first stirred and dissolved at 60 °C for 12 h, and then left to stand and defoam at 60 °C for 12 h to obtain a clear and transparent casting solution. The defoamed casting solution was slowly and evenly poured onto a clean glass plate, and a scraper with a gap thickness of 150 μm was used to scrape the casting solution into a thin film shape. Then, the glass plate with the casting solution was immersed in the coagulation bath water. The film-forming temperature and humidity were 25 °C and 40 RH% respectively. The solvent in the casting solution was exchanged with the coagulation bath, and phase separation occurred, finally transforming into a solid thin film. The prepared membrane was immersed in deionized water for 12 h to fully displace the organic solvent in the membrane pores. Then, the membrane was immersed in fresh deionized water and transferred to a 4 °C refrigerator for low-temperature storage.

[0038] The prepared ultrafiltration membrane was tested for BSA protein adsorption. The test process is as follows: (1) Preparation of phosphate buffer solution (PBS): Accurately weigh 0.24 g of potassium dihydrogen phosphate (KH 2 PO 4 ), 1.44 g of disodium hydrogen phosphate (Na 2 HPO 4 ), 8 g of sodium chloride (NaCl), and 0.2 g of potassium chloride (KCl). Add about 800 mL of pure water and stir well to dissolve. Then, add concentrated hydrochloric acid to adjust the pH to 7.4, and finally make up the volume to 1 L.

[0039] (2) Preparation of BSA solution: Accurately weigh 0.125 g of BSA with an electronic balance, dissolve it with PBS buffer solution, and finally make up the volume to 0.5 L.

[0040] (3) Immerse the membrane to be tested in pure water for more than 30 min, cut two relatively defect-free membrane pieces with an area of 0.01 m 2 , and then wash the surface of the membrane pieces with pure water and remove the membrane filaments at the edges.

[0041] (4) Put the membrane pieces into two clean 100 mL transparent glass vials with lids respectively, add 120 mL of the prepared BSA solution to completely immerse the membrane pieces; at the same time, take the same vials, do not add membrane pieces, and directly add 120 mL of BSA solution as a blank control. Leave 5 - 10 mL of the remaining BSA solution for testing as the stock solution.

[0042] (5) Place three vials at room temperature (25 ± 2 °C). After static adsorption for 7 hours, take a certain amount of solution in the vials, and use a UV spectrophotometer to measure the absorbance at a wavelength of 280 nm respectively, and record the data. For the above-mentioned stock solution, measure and record the data in the same way.

[0043] (6) Calculate the corresponding concentration using the standard curve, and finally calculate the adsorption amount (mg) per unit area (m 2 ) of the membrane. The test results are shown in Table 1.

[0044]

[0045] It can be seen from Table 1 that introducing polyoxazoline or its derivatives into the block copolymer can further improve the anti-fouling performance of the separation membrane. The manufacturer of Biomax-50 KDa is merck, and the model is Biomax-50. The manufacturer of Zhongke Ruiyang PES is Zhongke Ruiyang Membrane Technology Co., Ltd., and the model is UE030.

[0046] (2) Use the block copolymer materials prepared in the examples and comparative examples to prepare phase inversion membranes. The preparation process is as follows: First, dissolve the block copolymer material in a certain amount of DMSO solvent. Stir and dissolve it at 60 °C for 12 h, and then let it stand and defoam at 60 °C for 12 h to obtain a clear and transparent casting solution. Slowly and evenly pour the defoamed casting solution onto a clean glass plate, and use a doctor blade with a gap thickness of 150 μm to scrape the casting solution into a thin film shape, and then immerse the glass plate with the casting solution in the coagulation bath water. The film formation temperature and humidity are 25 °C and 40 RH% respectively. The solvent exchange between the casting solution and the coagulation bath occurs, and phase separation occurs, and finally it is transformed into a solid thin film. Immerse the prepared membrane in deionized water for 12 h to fully displace the organic solvent in the membrane pores. Then immerse the membrane in fresh deionized water and transfer it to a 4 °C refrigerator for low-temperature storage.

[0047] The test process of the pure water permeability coefficient and BSA rejection rate of the phase inversion membrane is as follows: Test the water flux of the prepared phase inversion membrane and the rejection rate of the membrane to bovine serum albumin (BSA). First, place the fully wet membrane sample in a cross-flow ultrafiltration test device, pre-press the membrane sample at a pressure of 0.1 MPa for 30 minutes, and then test it at 0.1 MPa. Record the mass change of pure water passing through the ultrafiltration membrane under this pressure, and the test process lasts for 30 minutes. Use a 100 ppm BSA solution as the feed solution, measure the rejection rate of the membrane to BSA at 1.0 bar, and measure the concentration of BSA by a UV spectrophotometer (UV 2700, Shimadzu).

[0048] The tests are shown in Table 2 and Table 3.

[0049]

[0050] As can be seen from Table 3, the pure water permeability coefficient of the polysulfone-based block copolymer material prepared by the present invention is about 2000 LMH / bar, far exceeding that of the PES membrane material, and the rejection rate of BSA reaches 98%. The PES material was obtained by direct purchase.

[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that they can still modify or equivalently replace the technical solutions of the present invention, and these modifications or equivalent replacements cannot make the modified technical solutions deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A method for synthesizing a polysulfone block copolymer, characterized in that: The following steps are involved: (a) adding aromatic diphenol monomer, aromatic dihalogenated compound monomer, salt-forming agent, organic solvent and water-carrying agent into a reaction kettle under nitrogen or argon atmosphere, heating at 100-150°C for salt-forming and dehydration for 1-24 h, and then raising the temperature to 160-250°C for high-temperature polymerization reaction for 1-10 h; (b) In the above system (a), the temperature of the reactor is lowered to 100-150° C., and then a hydrophilic material is added to react for 1-6 hours to obtain a reaction liquid; the hydrophilic material is one or more of poly(2-methyl-2-oxazoline), poly(2-ethyl-2-oxazoline), poly(2-isopropyl-2-oxazoline), poly(2-butyl-2-oxazoline), and poly(2-phenyl-2-oxazoline); (c) The reaction solution is cooled, filtered, precipitated in water, washed and dried to obtain a polysulfone block copolymer.

2. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: In step (a), the aromatic diphenol monomer is one or more of bisphenol A, bisphenol S, biphenol, hydroquinone, 4,4'-dihydroxybiphenyl, 4,4'-dihydroxydiphenyl ether, 4,4'-dihydroxydiphenyl sulfide, 4,4'-dihydroxydiphenylmethane, 3,3'-dihydroxydiphenylamine, 2,2'-dihydroxybiphenyl, 2,2'-dihydroxydiphenylmethane, 2,6'-dihydroxynaphthalene, and 2,7'-dihydroxynaphthalene.

3. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: In step (a), the aromatic dihalogenated compound monomer is one or more of p-fluorodiphenyl sulfone, p-chlorodiphenyl sulfone, p-bromodiphenyl sulfone, 4,4'-difluorobenzophenone, and 4,4'-dichlorobenzophenone.

4. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: In step (a), the salt-forming agent is one or more of potassium carbonate, sodium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride, potassium hydride, metallic sodium, lithium diisopropylamide, lithium bistrimethylsilylamide, and sodium bis(trimethylsilyl)amide.

5. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: In step (a), the organic solvent is one or more of N'N-dimethylacetamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, and sulfolane.

6. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: In step (a), the water-carrying agent is one or more of benzene, toluene, xylene, chlorobenzene, ethylbenzene, trimethylbenzene, pyridine and cyclohexane.

7. The method for synthesizing a polysulfone block copolymer according to claim 1, characterized in that: The molar ratio of the aromatic diphenol monomer, the aromatic dihalogenated compound monomer, the salt-forming agent and the polyoxazoline or its derivative is 1: (0.8-1.2): (1-6): (0.001-1); wherein the organic solvent required for each mole of the aromatic diphenol monomer is 0.2-3 L, and the water-carrying agent required is 0.1-2 L.

8. Application of the polysulfone block copolymer prepared by the synthesis method according to any one of claims 1 to 7 in the fields of biology, medicine, pharmaceuticals, semiconductors, environmental protection, and membrane separation.

9. The use of the polysulfone block copolymer according to claim 8, characterized in that: Application of polysulfone block copolymers in membrane separation. After polysulfone block copolymers are made into separation membranes, the BSA protein adsorption capacity is less than 35 ug / cm 2 , the pure water permeability coefficient is greater than 2000 LMH / bar, and the BSA retention rate is greater than 95%.

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