Flow cell fixing device, flow cell assembly and biochemical substance reaction device

Abstract

The invention discloses a flow cell fixing device, a flow cell assembly and a biochemical substance reaction device. The flow cell fixing device is used for fixing the flow cell supported on the bearing platform. The flow cell fixing device comprises a pressing mechanism. The pressing mechanism comprises a driving part and a pressing claw assembly, the pressing claw assembly comprises a pressing claw, a guiding part and a first rotating shaft, the pressing claw is connected with the driving part, the guiding part is fixedly connected with the bearing platform, the guiding part is provided with an arc-shaped groove, and the first rotating shaft is in sliding fit with the arc-shaped groove and is rotationally connected with the pressing claw; the arc-shaped groove is provided with a first end close to the flow cell and a second end far away from the flow cell; when the driving piece drives the pressing claw to enable the first rotating shaft to slide from the second end to the first end, the pressing claw moves towards the flow cell to press the flow cell; when the driving piece drives the pressing claw to enable the first rotating shaft to slide from the first end to the second end, the pressing claw is far away from the flow cell to loosen the flow cell.

Description

Technical Field

[0001] The present application relates to the technical field of biochemical reaction, and in particular to a flow cell fixing device, a flow cell assembly and a biochemical substance reaction device. Background Art

[0002] In the field of biochemical reactions, a flow cell is generally configured to carry a sample. A flow cell is a sample carrier for loading a sample of a biochemical substance and performing a detection and analysis reaction, and usually contains a cavity for accommodating the sample and a fluid. In the case of sequencing, the flow cell is a sequencing chip, and in other cases, the flow cell can be other sample carriers. In the field of sequencing, the flow cell is generally also referred to as a flow cell, a reaction cell, a chip, a sequencing chip, a gene sequencing chip or a cartridge, etc. During the sequencing process, the flow cell needs to be fixed by a flow cell fixing device. The existing flow cell fixing device has a complex structure, and the fixing and positioning operations of the flow cell are relatively cumbersome, with low convenience. Summary of the Invention

[0003] An object of the present application is to provide a flow cell fixing device with a simple structure and convenient operation.

[0004] In addition, the present application also provides a flow cell assembly applying the flow cell fixing device and a biological substance reaction device applying the flow cell assembly.

[0005] In the first aspect of the present application, a flow cell fixing device is provided, which is used to fix and support a flow cell on a carrying platform. The flow cell fixing device includes a pressing mechanism, and the pressing mechanism includes a driving member and a claw assembly. The claw assembly includes a claw, a guiding member and a first rotating shaft. The claw is connected to the driving member. The guiding member is configured to be fixedly connected to the carrying platform. The guiding member is provided with an arc-shaped groove. The first rotating shaft is slidably engaged with the arc-shaped groove and is rotatably connected to the claw. The arc-shaped groove has a first end close to the flow cell and a second end far from the flow cell. When the driving member drives the claw to make the first rotating shaft slide from the second end towards the first end, the claw moves towards the flow cell to press the flow cell. When the driving member drives the claw to make the first rotating shaft slide from the first end towards the second end, the claw moves away from the flow cell to release the flow cell.

[0006] According to some embodiments of the present application, the pressing mechanism further includes a connecting plate and a connecting rod. The connecting plate is connected to the driving member. The connecting plate is provided with a through hole. One end of the connecting rod is movably received in the through hole, and the other end of the connecting rod is rotatably connected to the claw.

[0007] According to some embodiments of the present application, one end of the connecting rod is provided with a sliding groove communicating with the through hole. The claw assembly further includes a connecting shaft, and the connecting shaft is slidably engaged with the sliding groove and is fixedly connected to the connecting plate.

[0008] According to some embodiments of the present application, the pressing jaw assembly further includes an elastic member. The connecting rod has a boss protruding from the peripheral edge, and the boss is located between the pressing jaw and the connecting shaft. The elastic member is elastically connected between the boss and the connecting shaft.

[0009] According to some embodiments of the present application, the pressing jaw is provided with a slot, and one end of the connecting rod is received in the slot and rotatably connected to the pressing jaw through a second rotating shaft.

[0010] According to some embodiments of the present application, the guiding member is further provided with a linear groove, and the pressing jaw assembly further includes a third rotating shaft, which is slidably matched with the linear groove and rotatably connected to the pressing jaw.

[0011] According to some embodiments of the present application, the pressing jaw includes a first protrusion, a second protrusion, and a recess located between the first protrusion and the second protrusion. The first protrusion is closer to the flow cell than the second protrusion. The position of the first rotating shaft corresponds to the position of the first protrusion, and the position of the third rotating shaft corresponds to the position of the second protrusion. The pressing jaw assembly further includes a fourth rotating shaft, which is rotatably matched with the recess and fixedly connected to the guiding member.

[0012] According to some embodiments of the present application, the driving member includes a driving body and a driving rod. The driving body is used to drive the driving rod to move towards or away from the flow cell. The driving rod is connected to the pressing jaw. The pressing mechanism further includes a sensor assembly and a controller. The sensor assembly is used to sense the position of the driving rod, and the controller is used to respond to the sensing information of the sensor assembly and control the driving rod to stop moving through the driving body.

[0013] The second aspect of the present application provides a flow cell assembly, including a flow cell, a bearing platform, and any one of the above flow cell fixing devices.

[0014] The third aspect of the present application provides a biochemical substance reaction device, which is used to load the flow cell assembly and input reaction substances into the flow cell to cause a reaction of the sample in the flow cell; or, the biochemical substance reaction device is further used to detect the reacted sample to obtain a signal reflecting the biological characteristics of the sample.

[0015] The flow cell fixing device provided by the embodiments of the present application uses the driving member as a power source to drive the pressing jaw assembly to move, and is configured with an arc groove a for controlling the movement trajectory of the pressing jaw during the movement on the guiding member, so that the driving member can drive the pressing jaw to move towards the flow cell to clamp the flow cell, or drive the pressing jaw to move away from the flow cell to release the flow cell. The overall structure of the device is simple and the operation is convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The above and / or additional aspects and advantages of the present application will become apparent and easy to understand from the description of the embodiments in conjunction with the following drawings, in which:

[0017] Figure 1Schematic three-dimensional structure diagram of the flow cell assembly provided by an embodiment of the present application.

[0018] Figure 2 It is Figure 1 Schematic three-dimensional structure diagram of the pressing mechanism of the flow cell assembly shown.

[0019] Figure 3 It is a cross-sectional view along Figure 2 III-III shown.

[0020] Figure 4 It is Figure 2 Partial exploded view of the pressing mechanism shown.

[0021] Description of main element symbols

[0022] Flow cell assembly 200

[0023] Flow cell 210

[0024] Carrying platform 220

[0025] Flow cell fixing device 100

[0026] Pressing mechanism 10

[0027] Driving part 11

[0028] Pressing jaw assembly 12

[0029] Pressing jaw 121

[0030] Guide part 122

[0031] First rotating shaft 123

[0032] Arc-shaped groove 122a

[0033] First end 122a1, 124a1, 122b1

[0034] Second end 122a2, 124a2, 122b2

[0035] Base 20

[0036] Bottom plate 21

[0037] Side plate 23

[0038] Accommodating space 20a

[0039] Fixing plate 111

[0040] Driving main body 112

[0041] Driving rod 113

[0042] Connecting plate 13

[0043] Plate body part 131

[0044] Bump 132

[0045] Pins 133, 128

[0046] Link 124

[0047] Through hole 131a

[0048] Connecting shaft 1241

[0049] Chute 124a

[0050] Slots 121a, 128

[0051] Second rotating shaft 125

[0052] Elastic member 126

[0053] Boss 1242

[0054] Linear groove 122b

[0055] Third rotating shaft 127

[0056] First protrusion 1211

[0057] Second protrusion 1212

[0058] Recess 1213

[0059] Fourth rotating shaft 129

[0060] Sensor assembly 14

[0061] Position sensor 141

[0062] Inductive sheet 142

[0063] Groove 141a Detailed implementation manner

[0064] The technical solutions in the embodiments of the present application will be described clearly and in detail below. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments, and are not intended to limit this application.

[0065] In addition, for the sake of brevity and clarity, in the accompanying drawings, the sizes or thicknesses of various components and layers may be enlarged. Throughout the text, the same numerical values refer to the same elements. As used herein, the terms "and / or", "as well as / or" include any and all combinations of one or more of the associated listed items. Additionally, it should be understood that when element A is referred to as being "connected" to element B, element A may be directly connected to element B, or there may be an intermediate element C and element A and element B may be indirectly connected to each other.

[0066] Furthermore, when describing the embodiments of the present application, the use of "may" refers to "one or more embodiments of the present application".

[0067] The technical terms used herein are for the purpose of describing specific embodiments and are not intended to limit the present application. As used herein, the singular form is intended to also include the plural form unless the context clearly indicates otherwise. It should be further understood that the term "comprising", when used in this specification, refers to the presence of the recited features, numerical values, steps, operations, elements, and / or components, but does not preclude the presence or addition of one or more other features, numerical values, steps, operations, elements, components, and / or combinations thereof.

[0068] It should be understood that although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers, and / or parts, these elements, components, regions, layers, and / or parts should not be limited by these terms. These terms are used to distinguish one element, component, region, layer, or part from another element, component, region, layer, or part. Thus, the first element, component, region, layer, or part discussed below may be referred to as the second element, component, region, layer, or part without departing from the teachings of the exemplary embodiments.

[0069] Please refer to Figure 1 and Figure 2 , an embodiment of the present application provides a flow cell assembly 200, including a flow cell 210, a carrier platform 220, and a flow cell fixing device 100. The flow cell 210 is supported on the carrier platform 220, and the flow cell fixing device 100 is used to press the flow cell 210 onto the carrier platform 220 to achieve fixation. The flow cell fixing device 100 includes a pressing mechanism 10 located on one side of the flow cell 210. Please refer to Figure 1 and Figure 2, the pressing mechanism 10 includes a driving member 11 and a claw assembly 12. The claw assembly 12 includes a claw 121, a guiding member 122, and a first rotating shaft 123. The claw 121 is connected to the driving member 11, and the driving member 11 is configured to drive the claw 121 to move towards or away from the flow cell 210. The guiding member 122 is fixedly connected to the carrying platform 220 and is provided with an arc-shaped groove 122a. The first rotating shaft 123 is slidably engaged with the arc-shaped groove 122a and is rotatably connected to the claw 121. The arc-shaped groove 122a has a first end 122a1 close to the flow cell 210 and a second end 122a2 far from the flow cell 210. When the driving member 11 drives the claw 121 to make the first rotating shaft 123 slide from the second end 122a2 towards the first end 122a1, the claw 121 moves towards the flow cell 210. When the first rotating shaft 123 is located at the first end 122a1, the claw 121 abuts against the flow cell 210 and presses the flow cell 210 against the carrying platform 220. When the driving member 11 drives the claw 121 to make the first rotating shaft 123 slide from the first end 122a1 towards the second end 122a2, the claw 121 moves in a direction away from the flow cell 210 to release the flow cell 210. When the first rotating shaft 123 is located at the second end 122a2, the claw 121 disengages from the flow cell 210 and is spaced apart from the flow cell 210 by a preset distance to facilitate removing the flow cell 210 from the carrying platform 220. In this embodiment, the number of the pressing mechanisms 10 is two, and the two pressing mechanisms 10 are located on opposite sides of the flow cell 210. In other embodiments, the number of the pressing mechanisms 10 can be set according to actual needs, for example, one, three, or four, etc. Among them, one pressing mechanism 10 can be located on any side of the flow cell 210, three pressing mechanisms 10 can be located on three adjacent sides of the flow cell 210, and four pressing mechanisms 10 can be evenly spaced around the periphery of the flow cell 210.

[0070] Please refer to Figure 1 , in some embodiments, the flow cell fixing device 100 further includes a base 20. The base 20 is used to carry the pressing mechanism 10 and the carrying platform 220. The base 20 includes a bottom plate 21 and two side plates 23 disposed on opposite sides of the bottom plate 21. The bottom plate 21 and the two side plates 23 enclose to form an accommodating space 20a. The carrying platform 220 is disposed at one end of the two side plates 23 away from the bottom plate 21.

[0071] The driving member 11 is fixed to the base plate 21 through the fixing plate 111, and is contained in the containing space 20a, and is located below one side of the carrying platform 220. The driving member 11 includes a driving body 112 and a driving rod 113. The driving body 112 is fixed to the base plate 21 through the fixing plate 111. The driving rod 113 is movably connected to the driving body 112, and is located on the side of the driving body 112 away from the base plate 21. The driving body 112 is used to drive the driving rod 113 to rise or fall to move toward or away from the flow pool 210, and then drive the pressure claw 121 to move toward or away from the flow pool 210. The driving member can be an electric push rod, an electric cylinder, a pneumatic cylinder, etc. In the present embodiment, the driving member 11 is an electric push rod.

[0072] See also Figure 1 , Figure 2 and Figure 3 The clamping mechanism 10 also includes a connecting plate 13 for connecting the pressing claw assembly 12 and the driving member 11. The connecting plate 13 is roughly T-shaped, which is accommodated in the accommodating space 20a and is located below one side of the carrying platform 220. The connecting plate 13 includes a plate body 131 and a protrusion 132 protruding from the plate body 131. The protrusion 132 is provided with a connecting hole (not shown), and one end of the driving rod 113 is accommodated in the connecting hole and is fixedly connected to the protrusion 132 by a latch 133. The latch 133 penetrates the driving rod 113 and the protrusion 132, and is fixedly connected to the driving rod 113 and the protrusion 132. When the driving body 112 drives the driving rod 113 to move toward or away from the flow pool 210, the connecting plate 13 moves toward or away from the flow pool 210 along with the driving rod 113. In this embodiment, the number of the pressure claw assemblies 12 is two, and the two pressure claw assemblies 12 are arranged at opposite ends of the plate body 131, and the protrusion 132 is arranged in the middle of the plate body 131, so that the driving member 11 drives the two pressure claw assemblies 12 to move smoothly. In other embodiments, the number of the pressure claw assemblies 12 can be one or more than two, and the relative positions between the pressure claw assemblies 12, the connecting plate 13 and the driving member 11 can be changed according to actual needs, as long as the driving member 11 can drive the pressure claw assemblies 12 to move smoothly through the connecting plate 13.

[0073] See also Figure 2 , Figure 3 and Figure 4, the pressing jaw assembly 12 further includes a connecting rod 124. The plate body portion 131 is provided with a through hole 131a that penetrates the plate body portion 131. One end of the connecting rod 124 is movably received in the through hole 131a and is connected to the plate body portion 131 through a connecting shaft 1241. A sliding groove 124a communicating with the through hole 131a is provided at one end of the connecting rod 124. The connecting shaft 1241 is slidably engaged with the sliding groove 124a and penetrates the plate body portion 131 to be fixedly connected to the connecting plate 13. The sliding groove 124a includes a first end 124a1 close to the flow cell 210 and a second end 124a2 far from the flow cell 210. A preset distance is provided between the first end 124a1 and the second end 124a2, and the connecting shaft 1241 can slide between the first end 124a1 and the second end 124a2. When the connecting plate 13 moves toward or away from the flow cell 210 along with the driving rod 113, the connecting rod 124 moves toward or away from the flow cell 210 along the through hole 131a along with the connecting plate 13. At the same time, the connecting shaft 1241 moves along the sliding groove 124a.

[0074] The pressing jaw 121 is provided with a slot 121a. One end of the connecting rod 124 far from the connecting plate 13 is received in the slot 121a and is rotatably connected to the pressing jaw 121 through a second rotating shaft 125. In this embodiment, the slot 121a is a groove with two open sides, which penetrates two adjacent surfaces of the pressing jaw 121, so that the rotation angle of the pressing jaw 121 along the second rotating shaft 125 is large enough. In other embodiments, the slot 121a may be a groove with one open side or a groove with three open sides, which is not limited in this application. When the connecting rod 124 moves toward or away from the flow cell 210 along the through hole 131a along with the connecting plate 13, the connecting rod 124 drives the pressing jaw 121 to rotate toward or away from the flow cell 210 around the second rotating shaft 125. At the same time, the pressing jaw 121 moves along the arc-shaped groove 122a.

[0075] The pressing jaw assembly 12 further includes an elastic member 126. The connecting rod 124 has a boss 1242 protruding from the periphery. The boss 1242 is located between the pressing jaw 121 and the connecting shaft 1241. The elastic member 126 is elastically connected between the boss 1242 and the connecting shaft 1241 and is used to provide a floating force for the pressing jaw 121 when the pressing jaw 121 presses the flow cell 210, so as to protect the flow cell 210 from being damaged due to excessive pressure of the pressing jaw 121. In this embodiment, the elastic member 126 is a spring. The elastic member 126 is sleeved on the connecting rod 124 and abuts between the boss 1242 and the connecting shaft 1241. In other embodiments, the elastic member 126 is a spring sheet, and both ends of the elastic member 126 are connected to the boss 1242 and the connecting shaft 1241.

[0076] The guiding member 122 is fixedly connected to the bearing platform 220 and is located below the bearing platform 220. The guiding member 122 is further provided with a linear groove 122b which extends from one end close to the bearing platform 220 towards the other end away from the bearing platform 220. The jaw assembly 12 further includes a third rotating shaft 127. The third rotating shaft 127 is slidably engaged with the linear groove 122b and is rotatably connected to the jaw 121. The linear groove 122b has a first end 122b1 close to the flow cell 210 and a second end 122b2 away from the flow cell 210. When the first rotating shaft 123 moves from the first end 122a1 of the arc-shaped groove 122a towards its second end 122a2, the third rotating shaft 127 moves from the first end 122b1 of the linear groove 122b towards its second end 122b2; conversely, when the first rotating shaft 123 moves from the second end 122a2 of the arc-shaped groove 122a towards its first end 122a1, the third rotating shaft 127 moves from the second end 122b2 of the linear groove 122b towards its first end 122b1. In this embodiment, when the jaw 121 rotates around the second rotating shaft 125 such that the first rotating shaft 123 is located at the first end 122a1 of the arc-shaped groove 122a, the third rotating shaft 127 is located at the first end 122b1 of the linear groove 122b; when the jaw 121 rotates around the second rotating shaft 125 such that the first rotating shaft 123 is located at the second end 122a2 of the arc-shaped groove 122a, the third rotating shaft 127 is located at the second end 122b2 of the linear groove 122b.

[0077] Please refer to Figure 2 , in this embodiment, each jaw assembly 12 includes two guiding members 122. The two guiding members 122 are disposed on opposite sides of the jaw 121 and are connected by a pin 128. The jaw 121 is limited between the two guiding members 122 to prevent the situation where the jaw 121 disengages from the first rotating shaft 123 and / or the third rotating shaft 127 when the jaw 121 rotates.

[0078] Please refer to Figure 1 , Figure 3 and Figure 4 , a part of the jaw 121 extends out of the guiding member 122 and is located above the bearing platform 220. The jaw 121 includes a first protrusion 1211, a second protrusion 1212, and a recess 1213 located between the first protrusion 1211 and the second protrusion 1212. In the moving direction of the driving rod 113, the first protrusion 1211 is closer to the flow cell 210 than the second protrusion 1212. The position of the first rotating shaft 123 corresponds to the position of the first protrusion 1211, and the position of the third rotating shaft 127 corresponds to the position of the second protrusion 1212. The jaw assembly 12 further includes a fourth rotating shaft 129. The fourth rotating shaft 129 is rotatably engaged with the recess 1213 and is fixedly connected to the guiding member 122 for limiting the rotation of the jaw 121.

[0079] Please refer toFigure 1 , the pressing mechanism 10 further includes a sensor assembly 14 and a controller (not shown in the figure). Both the sensor assembly 14 and the driving member 11 are electrically connected to the controller. The sensor assembly 14 is used to sense the position of the driving rod 113, and the controller is used to respond to the sensing information of the sensor assembly 14 and control the driving rod 113 to stop rising or falling through the driving body 112, and control the position where the driving rod 113 stops rising or falling. The sensor assembly 14 includes a position sensor 141 and a sensing piece 142. The sensing piece 142 is fixed to the connecting plate 13. The position sensor 141 is detachably mounted on the side plate 23 and is used to send a sensing signal to the controller when the sensing piece 142 approaches. The controller is used to respond to the sensing signal of the position sensor 141 to control the lifting of the driving rod 113. The position sensor 141 has a groove 141a. The groove 141a is configured to allow the sensing piece 142 to be inserted to sense the position of the driving rod 113. In this embodiment, the sensor assembly 14 includes two position sensors 141. The two position sensors 141 are spaced apart at the edge of the side plate 23. One position sensor 141 is used to sense the position where the driving rod 113 stops rising, and the other position sensor 141 is used to sense the position where the driving rod 113 stops falling.

[0080] The flow cell fixing device 100 provided by the embodiment of the present application uses the driving member 11 as a power source to drive the claw assembly 12 to move, and is configured with an arc-shaped groove 122a on the guide member 122 for controlling the movement trajectory of the claw 121 during the movement, so that the driving member 11 can drive the claw 121 to move towards the flow cell 210 to press the flow cell 210, or drive the claw 121 to move away from the flow cell 210 to release the flow cell 210. The overall structure of the device is simple and the operation is convenient.

[0081] An embodiment of the present application provides a biochemical substance reaction device applying a flow cell assembly 200. The biochemical substance reaction device is used to load the flow cell assembly 200 and input reaction substances into the flow cell 210 to cause the samples in the flow cell 210 to react; or, the biochemical substance reaction device is further used to detect the reacted samples to obtain signals of the biological characteristics of the reaction samples. The biochemical substance reaction device can be a gene sequencer, a liquid chromatograph, a biochemical analyzer, a medical device, etc.

[0082] The above-disclosed is only the preferred embodiment of the present application. Of course, the present application cannot be limited by this. Therefore, the equivalent changes made according to the present application still fall within the scope covered by the present application.

Claims

1. A flow cell fixing device for fixing and supporting a flow cell on a carrying platform, Characterized in that, The flow cell fixing device includes a pressing mechanism, the pressing mechanism includes a driving member and a claw assembly, the claw assembly includes a claw, a guiding member and a first rotating shaft, the claw is connected to the driving member, the guiding member is configured to be fixedly connected to the carrying platform, the guiding member is provided with an arc-shaped groove, the first rotating shaft is slidably matched with the arc-shaped groove and rotatably connected to the claw, the arc-shaped groove has a first end close to the flow cell and a second end far from the flow cell; when the driving member drives the claw to make the first rotating shaft slide from the second end towards the first end, the claw moves towards the flow cell to press the flow cell; When the driving member drives the claw to make the first rotating shaft slide from the first end towards the second end, the claw moves away from the flow cell to release the flow cell.

2. The flow cell fixing device according to claim 1, Characterized in that, The pressing mechanism further includes a connecting plate and a connecting rod, the connecting plate is connected to the driving member, the connecting plate is provided with a through hole, one end of the connecting rod is movably received in the through hole, and the other end of the connecting rod is rotatably connected to the claw.

3. The flow cell fixing device according to claim 2, Characterized in that, One end of the connecting rod is provided with a sliding groove communicating with the through hole, the claw assembly further includes a connecting shaft, the connecting shaft is slidably matched with the sliding groove and fixedly connected to the connecting plate.

4. The flow cell fixing device according to claim 3, Characterized in that, The claw assembly further includes an elastic member, the connecting rod has a boss protruding from the periphery, the boss is located between the claw and the connecting shaft, and the elastic member is elastically connected between the boss and the connecting shaft.

5. The flow cell fixing device according to claim 2, Characterized in that, The claw is provided with a slot, one end of the connecting rod is received in the slot and rotatably connected to the claw through a second rotating shaft.

6. The flow cell fixing device according to claim 1, Characterized in that, The guiding member is further provided with a linear groove, the claw assembly further includes a third rotating shaft, the third rotating shaft is slidably matched with the linear groove and rotatably connected to the claw.

7. The flow cell fixing device according to claim 6, Characterized in that, The claw includes a first protrusion, a second protrusion and a recess located between the first protrusion and the second protrusion, the first protrusion is closer to the flow cell than the second protrusion, the position of the first rotating shaft corresponds to the position of the first protrusion, the position of the third rotating shaft corresponds to the position of the second protrusion, the claw assembly further includes a fourth rotating shaft, the fourth rotating shaft is rotatably matched with the recess and fixedly connected to the guiding member.

8. The flow cell fixing device according to claim 1, Characterized in that, The driving member includes a driving body and a driving rod. The driving body is used to drive the driving rod to move towards or away from the flow cell. The driving rod is connected to the pressing claw. The pressing mechanism further includes a sensor assembly and a controller. The sensor assembly is used to sense the position of the driving rod, and the controller is used to respond to the sensing information of the sensor assembly and control the driving rod to stop moving through the driving body.

9. A flow cell assembly, characterized in that it includes a flow cell, a carrying platform, and the flow cell fixing device according to any one of claims 1-8.

10. A biochemical substance reaction device, characterized in that the biochemical substance reaction device is used to load the flow cell assembly according to claim 9 and input reaction substances into the flow cell to cause the samples in the flow cell to react; or, the biochemical substance reaction device is further used to detect the reacted samples to obtain signals reflecting the biological characteristics of the samples.

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