Microplate reader suitable for microorganism drug resistance test

Abstract

The invention relates to the technical field of microplate readers, and discloses a microplate reader suitable for a microorganism drug resistance test. The device comprises a machine shell, the machine shell is in sliding connection with a bracket used for containing a microwell plate through an electric sliding rail arranged in the machine shell, the bracket is provided with a vibration mechanism used for making the microwell plate vibrate through a mounting cavity formed in the bracket, and a correction piece used for adjusting the position of the microwell plate is arranged between the lower surface of the microwell plate and the upper surface of the bracket. The microplate reader suitable for the microbiological drug resistance test can effectively solve the problems that in the prior art, an operator needs to adjust the position of a microplate, the position of the microplate deviates from the center position of a bracket, a light path irradiates the edge or adjacent micropores of the microplate, extra reflection, refraction or scattered light is generated, and the microplate is not prone to damage. The interference light can enter a detection system to influence the accuracy of a detection result, so that the judgment of an operator on the drug resistance of microorganisms is influenced.

Description

Technical Field

[0001] The present invention relates to the technical field of microplate readers, and particularly to a microplate reader suitable for microbial drug resistance tests. Background Art

[0002] A microplate reader, namely an enzyme-linked immunosorbent assay detector, is an instrument that uses enzyme-linked immunosorbent assay technology for detection. In microbial drug resistance tests, relevant samples are added to a microplate, and then the microplate is placed on a bracket. The microplate reader can measure the absorbance value of the bacterial solution at a specific wavelength, thereby judging the sensitivity of the microorganism to the drug.

[0003] In actual operation, the operator cannot ensure that the microplate is accurately placed at the center position of the bracket each time, resulting in the operator needing to adjust the position of the microplate to avoid its deviation from the center position of the bracket, which causes the light path to irradiate the edge of the microplate or adjacent microholes, generating additional reflected, refracted, or scattered light. These interfering lights will enter the detection system, affecting the accuracy of the detection results, and thus affecting the operator's judgment of microbial drug resistance. Summary of the Invention

[0004] Technical Problems to be Solved In view of the above-mentioned drawbacks of the prior art, the present invention provides a microplate reader suitable for microbial drug resistance tests, which can effectively solve the problem in the prior art that the operator needs to adjust the position of the microplate to avoid its deviation from the center position of the bracket, resulting in the light path irradiating the edge of the microplate or adjacent microholes, generating additional reflected, refracted, or scattered light. These interfering lights will enter the detection system, affecting the accuracy of the detection results, and thus affecting the operator's judgment of microbial drug resistance.

[0005] To achieve the above objectives, the present invention is realized through the following technical solutions: The present invention provides a microplate reader suitable for microbial drug resistance tests, comprising: A microplate; A housing, the housing is slidably connected with a bracket for placing the microplate through an electric slide rail arranged inside it. The bracket is provided with a vibration mechanism for vibrating the microplate through an installation cavity arranged inside it. A correction member for adjusting the position of the microplate is arranged between the lower surface of the microplate and the upper surface of the bracket; Among them, the correction member includes correction rods. The correction rods are arranged at the bottom end of the microplate. There are four correction rods and they are symmetrically distributed around the center of the microplate. A correction sleeve that fits the outer circumferential surface of the correction rod is arranged in the cavity of the bracket. When the correction rod is inserted into the correction sleeve, the microplate is in the centered position on the bracket.

[0006] Further, the vibration mechanism includes a rotating shaft rotatably connected inside the cavity of the bracket. An eccentric wheel is fixedly connected to the outer circumferential surface of the rotating shaft, and a driven gear is fixedly connected to one end of the rotating shaft close to the electric slide rail. The bracket is slidably connected with a guide plate through a guide hole opened on its upper surface, and a contact plate that fits against the outer circumferential surface of the eccentric wheel is fixedly connected to the top end of the guide plate. The guide plate is connected to the top end of the bracket through a return spring arranged on its lower surface.

[0007] Further, a driving motor is fixedly connected inside one side of the bracket close to the electric slide rail, and a driving gear meshing with the driven gear is fixedly connected to the output end of the driving motor.

[0008] Further, the microplate includes a frame and a plate body. The plate body is connected to the inner wall of the frame through elastic members arranged on its side walls. Micropores for containing microbial drug resistance test samples are opened on the upper surface of the plate body.

[0009] Further, the calibration rod includes a plugging rod, the top end of the plugging rod is detachably installed at the bottom end of the frame, and a counterweight is fixedly connected to the plugging rod through an installation groove opened on its outer circumferential surface.

[0010] Further, the calibration sleeve includes a plugging sleeve. The outer circumferential surface of the plugging sleeve is detachably installed inside the cavity of the bracket. An activity hole is opened on the outer circumferential surface of the plugging sleeve, and an activity plate is rotatably connected inside the activity hole. An activity sleeve that fits against the outer circumferential surface of the plugging sleeve is rotatably connected to one side of the activity plate away from the central axis of the plugging sleeve. A calibration arc plate that abuts against the top of the activity sleeve is rotatably connected to the top end of the plugging sleeve.

[0011] Further, the plugging sleeve is slidably connected with an activity circular plate through a guide groove opened on its inner wall, and the activity circular plate is connected to the inner bottom end of the plugging sleeve through a compression spring arranged at its bottom end. The outer circumferential surface of the activity circular plate is rotatably connected to one side of the activity plate close to the central axis of the plugging sleeve; An electromagnetic block is fixedly connected to the lower surface of the plugging sleeve, and a magnetic connection is established between one side of the activity circular plate close to the compression spring and the electromagnetic block. A conical space is arranged inside the plugging sleeve.

[0012] The technical solution provided by the present invention has the following beneficial effects compared with the prior art: The present invention is provided with a calibration member. When the insertion rod is in the conical space of the insertion sleeve, the counterweight block in the insertion rod can be used to push the movable circular plate to move. The movable circular plate can drive the movable sleeve to push the calibration arc plate to move through the movable plate. As the calibration arc plate moves, the position of the insertion rod can be gradually calibrated. When the calibration arc plate moves to the vertical state, the central axis of the insertion rod will coincide with the central axis of the insertion sleeve at this time, so that the position of the microplate can be corrected, ensuring that the microplate is placed at the center position of the bracket every time. The operator does not need to deliberately adjust the position of the microplate every time, avoiding the deviation of the microplate from the center position of the bracket and affecting the accuracy of the detection result. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0014] Figure 1 is a three-dimensional structural schematic diagram of an embodiment of the present invention; Figure 2 is a three-dimensional structural schematic diagram of a bracket and a microplate in an embodiment of the present invention; Figure 3 is a three-dimensional separated structural schematic diagram of a vibration mechanism in an embodiment of the present invention; Figure 4 is an embodiment of the present invention Figure 3 is an enlarged schematic diagram of the structure at A in the figure; Figure 5 is an embodiment of the present invention Figure 3 is an enlarged schematic diagram of the structure at B in the figure; Figure 6 is a three-dimensional separated structural schematic diagram of a microplate and a calibration rod in an embodiment of the present invention; Figure 7 is an embodiment of the present invention Figure 6 is an enlarged schematic diagram of the structure at C in the figure; Figure 8 is a three-dimensional exploded structural schematic diagram of a calibration sleeve in an embodiment of the present invention; Figure 9 is a sectional structural schematic diagram of a calibration sleeve in an embodiment of the present invention; Figure 10 is a structural schematic diagram of the three-dimensional state transformation of a calibration arc plate in an embodiment of the present invention.

[0015] The reference numerals in the figure respectively represent: 1, microplate; 2, housing; 21, bracket; 22, vibration mechanism; 221, rotating shaft; 222, eccentric wheel; 223, driven gear; 224, guiding hole; 225, guiding plate; 226, abutting plate; 227, return spring; 228, drive motor; 229, driving gear; 23, calibration member; 231, calibration rod; 2311, inserting rod; 2312, mounting groove; 2313, counterweight; 232, calibration sleeve; 2321, inserting sleeve; 2322, moving hole; 2323, moving plate; 2324, moving sleeve; 2325, calibration arc plate; 2326, moving circular plate; 2327, compression spring; 2328, electromagnet. Detailed implementation manners

[0016] To make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Apparently, the described embodiments are some but not all of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0017] The present invention will be further described below with reference to the embodiments. Embodiment

[0018] Please refer to Figures 1-10 , the present invention provides a technical solution: an ELISA reader applicable to microbial drug resistance tests, comprising: Microplate 1; Housing 2, the housing 2 is slidably connected with a bracket 21 for placing the microplate 1 through an electric slide rail arranged inside it, the bracket 21 is provided with a vibration mechanism 22 for vibrating the microplate 1 through a mounting cavity arranged inside it, and a calibration member 23 for adjusting the position of the microplate 1 is arranged between the lower surface of the microplate 1 and the upper surface of the bracket 21; Among them, the calibration member 23 includes a calibration rod 231, the calibration rod 231 is arranged at the bottom end of the microplate 1, there are four calibration rods 231 and they are symmetrically distributed around the center of the microplate 1, and a calibration sleeve 232 that fits the circumferential outer surface of the calibration rod 231 is arranged in the cavity of the bracket 21. When the calibration rod 231 is inserted into the calibration sleeve 232, the microplate 1 is in the central position of the bracket 21.

[0019] The vibration mechanism 22 includes a rotating shaft 221, the rotating shaft 221 is rotatably connected to the inside of the cavity of the bracket 21, an eccentric wheel 222 is fixedly connected to the circumferential outer surface of the rotating shaft 221, and a driven gear 223 is fixedly connected to one end of the rotating shaft 221 close to the electric slide rail; The bracket 21 is slidably connected with a guide plate 225 through a guide hole 224 formed in its upper surface, and a contact plate 226 that fits against the outer circumferential surface of the eccentric wheel 222 is fixedly connected to the top end of the guide plate 225. The guide plate 225 is connected to the top end of the bracket 21 through a return spring 227 provided on its lower surface.

[0020] Inside the bracket 21 near one side of the electric slide rail, a driving motor 228 is fixedly connected, and a driving gear 229 that meshes with the driven gear 223 is fixedly connected to the output end of the driving motor 228.

[0021] The microplate 1 includes a frame and a plate body. The plate body is connected to the inner wall of the frame through elastic members provided on its side walls, and micro-holes for containing microbial drug resistance test samples are formed on the upper surface of the plate body.

[0022] The calibration rod 231 includes a plug-in rod 2311. The top end of the plug-in rod 2311 is detachably installed at the bottom end of the frame, and a counterweight 2313 is fixedly connected to the plug-in rod 2311 through an installation groove 2312 formed in its outer circumferential surface.

[0023] The calibration sleeve 232 includes a plug-in sleeve 2321. The outer circumferential surface of the plug-in sleeve 2321 is detachably installed in the cavity of the bracket 21. An activity hole 2322 is formed in the outer circumferential surface of the plug-in sleeve 2321, and an activity plate 2323 is rotatably connected in the activity hole 2322. An activity sleeve 2324 that fits against the outer circumferential surface of the plug-in sleeve 2321 is rotatably connected to one side of the activity plate 2323 away from the central axis of the plug-in sleeve 2321. A calibration arc plate 2325 that abuts against the top of the activity sleeve 2324 is rotatably connected to the top end of the plug-in sleeve 2321.

[0024] The plug-in sleeve 2321 is slidably connected with an activity circular plate 2326 through a guide groove formed in its inner wall, and the activity circular plate 2326 is connected to the inner bottom end of the plug-in sleeve 2321 through a compression spring 2327 provided at its bottom end. The outer circumferential surface of the activity circular plate 2326 is rotatably connected to one side of the activity plate 2323 close to the central axis of the plug-in sleeve 2321; An electromagnet 2328 is fixedly connected to the lower surface of the plug-in sleeve 2321. There is a magnetic connection between the side of the activity circular plate 2326 close to the compression spring 2327 and the electromagnet 2328. A conical space is provided inside the plug-in sleeve 2321.

[0025] The working principle and advantages of the microplate reader applicable to microbial drug resistance tests: First, the operator adds the bacterial solution pre-incubated in the incubator into the microplate 1. Then, the operator starts the microplate reader and operates it using the control panel on the housing 2. When the microplate reader starts working, the electric slide rail inside the housing 2 will send out the bracket 21 from the housing 2. At this time, the operator places the insertion rod 2311 at the lower part of the microplate 1 into the insertion sleeve 2321. Since a counterweight 2313 is installed inside the insertion rod 2311, the microplate 1, together with the gravity of the counterweight 2313, can make the insertion rod 2311 move downward along the insertion sleeve 2321.

[0026] When the insertion rod 2311 just enters the insertion sleeve 2321, the abutting rod on the movable circular plate 2326 will come into contact with the bottom end of the insertion rod 2311. As the insertion rod 2311 moves, at this time, the movable circular plate 2326 will move downward along the insertion sleeve 2321 synchronously, and the compression spring 2327 will be compressed. When the movable circular plate 2326 moves downward, the movable plate 2323 connected to its circumferential outer surface will follow the movable circular plate 2326 downward. Since the middle part of the movable plate 2323 is rotatably installed in the movable hole 2322 through a pin shaft, at this time, the side of the movable plate 2323 away from the movable circular plate 2326 will move upward with the pin shaft as the center (there are movable slot holes on both sides of the movable plate 2323. When the movable plate 2323 rotates along the pin shaft, there will be no movement interference between the movable plate 2323 and other components), so as to move the movable sleeve 2324 upward along the circumferential outer surface of the insertion sleeve 2321. At this time, the movable sleeve 2324 will push the calibration arc plate 2325 to gradually approach the central axis position of the insertion sleeve 2321 until the calibration arc plate 2325 moves to the vertical position. When the calibration arc plate 2325 moves from the initial position to the vertical position, during this process, the calibration arc plate 2325 will gradually push the insertion rod 2311 to move toward the central axis position of the insertion sleeve 2321 in the conical space. When the calibration arc plate 2325 moves to the vertical position, multiple calibration arc plates 2325 will form a "collar" with the central axis coinciding with the central axis of the insertion sleeve 2321 (the number of calibration arc plates 2325 can be set according to specific conditions. Here, three are preferred. The three arc plates can be evenly distributed in the circumferential direction of the top end of the insertion sleeve 2321 to form a stable support and guiding structure, and it is relatively simple in processing and installation. When the three calibration arc plates 2325 form a "collar", the diameter of the "collar" is slightly larger than the diameter of the insertion rod 2311, so that the insertion rod 2311 can slide in the "collar" in contact with its inner wall, ensuring that the insertion rod 2311 can move smoothly in the "collar"), so as to realize the coincidence of the central axes between the insertion rods 2311 at the four corners of the bottom end of the microplate 1 and the insertion sleeve 2321. At this time, with the cooperation of the insertion rod 2311, the insertion sleeve 2321 and the calibration arc plate 2325 of the microplate 1, the calibration arc plate 2325 plays a good guiding role, guiding the insertion rod 2311 to accurately enter the insertion sleeve 2321, ensuring that the central axes of the two can finally coincide, reducing the possibility of deviation and misalignment, and being able to realize the automatic calibration of the microplate 1 on the bracket 21, ensuring that the microplate 1 is always in the central position of the bracket 21.

[0027] It should be noted that the upper part of the inner wall of the insertion sleeve 2321 is provided with a conical space. When the insertion rod 2311 moves towards the insertion sleeve 2321, since the large end of the conical space faces outward, even when the insertion rod 2311 is offset to a certain extent, it can still smoothly contact the insertion sleeve 2321. The conical space plays a guiding role. The operator only needs to place the insertion rod 2311 inside the insertion sleeve 2321 without deliberately adjusting the position of the microplate 1. Utilizing the gravity of the counterweight 2313 inside the insertion rod 2311 and cooperating with the abutting arc plate on the insertion sleeve 2321, the central axes of the four insertion rods 2311 at the bottom end of the microplate 1 can be automatically aligned with the central axis of the insertion sleeve 2321, thereby ensuring that the microplate 1 can be in the center position of the bracket 21 each time. And the calibration process of the insertion rod 2311 is completed within the conical space of the insertion rod 2311. After the position calibration of the insertion rod 2311 is completed, the insertion rod 2311 can continue to move along the circular space at the lower part of the insertion sleeve 2321.

[0028] After the calibration of the insertion rod 2311 is completed, the insertion rod 2311 will enter the circular space inside the insertion sleeve 2321 and continue to move (the diameter of the circular space is the same as the diameter of the "loop" formed by the abutting arc plate). When the movable circular plate 2326 approaches the bottom of the insertion sleeve 2321, the electromagnetic block 2328 on the movable circular plate 2326 will quickly attract and combine with the bottom end of the insertion sleeve 2321 by using the magnetism generated by itself. Since the attraction process of the electromagnetic block 2328 is instantaneous, under the cooperation of the electromagnetic block 2328 and its own gravity (the electromagnetic block 2328 can control its magnetic force by controlling the magnitude of the current, and the magnetic force generated by the electromagnetic block 2328 is much greater than the elastic force of the compression spring 2327 itself), the acceleration of the movement of the movable circular plate 2326 will be greater than the acceleration of the movement of the insertion rod 2311. At this time, a drop will be formed between the upper surface of the movable circular plate 2326 and the bottom of the insertion rod 2311, so that the insertion rod 2311 will fall along the inner walls of the insertion sleeve 2321 and the "loop". When the insertion rod 2311 contacts the top of the movable circular plate 2326, the inner plate of the microplate 1 will vibrate in the frame at this time, so that the bubbles in the sample can move, gather and finally be discharged in the sample, thereby eliminating the influence of bubbles on the detection and improving the reliability of the detection data.

[0029] It should be noted that a buffer is provided at the top of the calibration arc plate 2325. When the microplate 1 falls with the insertion rod 2311, the buffer can buffer the microplate 1 to avoid the sample in the microplate from splashing due to excessive vibration amplitude, which affects the accuracy of the detection result.

[0030] After the microplate 1 is placed, the staff can use the control panel of the microplate reader again to move the bracket 21 and the microplate 1 into the housing 2. At this time, the drive motor 228 in the vibration mechanism 22 will drive the driving gear 229 to rotate. Since the driving gear 229 meshes with the driven gear 223, the rotating shaft 221 will drive the eccentric wheel 222 to rotate regularly. When the eccentric wheel 222 rotates under the lower part of the abutting plate 226, the abutting plate 226 will receive a periodically changing external force. Since the magnitude and direction of the centrifugal force change continuously with the rotation of the eccentric wheel 222, the external force received by the abutting plate 226 will also change periodically, so that the abutting plate 226 generates vibration. And the top of the abutting plate 226 is in contact with the bottom end of the microplate 1. Therefore, the microplate 1 can vibrate on the bracket 21, which can make the bacterial liquid and other reagents in the microplate 1 move continuously in the holes, break the concentration gradient that appears, ensure the uniform distribution of the bacterial liquid in the whole hole, make the opportunity for microorganisms in each part to contact the drug equal, thereby improving the accuracy and repeatability of the test results. At the same time, the vibration of the microplate 1 can accelerate the diffusion of drug molecules in the bacterial liquid, make the drug more evenly distributed in the bacterial liquid, fully contact with the microorganisms, and better play the antibacterial role of the drug, so as to accurately detect the sensitivity of microorganisms to the drug.

[0031] When the sample in the microplate 1 is processed, the detection element inside the microplate reader will detect the sample in the microplate 1. After the detection is completed, the electric slide rail in the housing 2 will move the bracket 21 and the microplate 1 out. At this time, the operator can remove the microplate 1 from the bracket 21. After the microplate 1 is removed from the bracket 21, the electromagnet 2328 under the movable circular plate 2326 will lose magnetism. At this time, the compression spring 2327 will reset the movable circular plate 2326, so that the movable plate 2323, the movable sleeve 2324 and the calibration arc plate 2325 will return to the initial position, which is convenient for the staff to use next time.

[0032] It should be noted that the insertion rod 2311 in the calibration rod 23 is detachably installed on the microplate 1. When not in use, the operator can remove it from the microplate 1, which is convenient for the staff to store the microplate 1. At the same time, the insertion sleeve 2321 in the calibration sleeve 232 can be detached from the bracket 21, which is convenient for later maintenance and repair.

[0033] The present invention adopts the calibration member 23 and has the following advantages: Advantage 1: A conical space is provided in the insertion sleeve 2321. The upper end of the conical space has a larger opening. The conical structure of the conical space can play a good guiding role. When inserting the insertion rod 2311, the conical opening end can guide the insertion rod 2311 to smoothly enter the insertion sleeve 2321, making it easier for the operator to align and insert, reducing the difficulty of insertion and improving the operation efficiency.

[0034] Advantage two: When the insertion rod 2311 is in the conical space of the insertion sleeve 2321, the counterweight 2313 in the insertion rod 2311 can be used to push the movable circular plate 2326 to move. The movable circular plate 2326 can drive the movable sleeve 2324 through the movable plate 2323 to push the calibration arc plate 2325 to move. As the calibration arc plate 2325 moves, the position of the insertion rod 2311 can be gradually calibrated. When the calibration arc plate 2325 moves to the vertical state, the central axis of the insertion rod 2311 will coincide with the central axis of the insertion sleeve 2321 at this time, so that the position of the microplate 1 can be corrected, ensuring that the microplate 1 is placed at the center of the bracket 21 each time. The operator does not need to deliberately adjust the position of the microplate 1 each time, avoiding the deviation of the center position of the microplate 1 from the bracket 21 and affecting the accuracy of the detection result.

[0035] Advantage three: When the microplate 1 corrects its position by using the insertion rod 2311 and the insertion sleeve 2321, the vibration of the microplate 1 can be realized by using the difference in the acceleration of motion between the movable circular plate 2326 and the insertion rod 2311. The bubbles in the sample can move, gather and finally be discharged in the sample, thereby eliminating the influence of bubbles on the detection and improving the reliability of the detection data.

[0036] Advantage four: When the calibration arc plate 2325 contacts the bottom end of the microplate 1, the buffer on the calibration arc plate 2325 will buffer the microplate 1 when it falls, which can avoid the excessive vibration amplitude of the microplate 1 and cause the sample in the microplate 1 to splash, affecting the accuracy of the detection result.

[0037] Advantage five: The insertion rod 2311 in the calibration rod 231 is detachably installed on the microplate 1. When not in use, the operator can remove it from the microplate 1, which is convenient for the staff to store the microplate 1. At the same time, the insertion sleeve 2321 in the calibration sleeve 232 can be detached from the bracket 21, which is convenient for later maintenance and repair.

[0038] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements will not make the essence of the corresponding technical solutions deviate from the protection scope of the technical solutions of the embodiments of the present invention.

Claims

1. An ELISA instrument suitable for microbial resistance testing, characterized in that: include: Microplate (1); A casing (2), the casing (2) being slidably connected to a bracket (21) for placing a microplate (1) via an electric slide rail arranged inside the casing (2), the bracket (21) being provided with a vibration mechanism (22) for causing the microplate (1) to vibrate via a mounting cavity arranged inside the bracket (21), and a correction member (23) for adjusting the position of the microplate (1) being provided between a lower surface of the microplate (1) and an upper surface of the bracket (21); The calibration member (23) comprises a calibration rod (231), the calibration rod (231) being arranged at the bottom end of the microplate (1), four calibration rods (231) being provided and symmetrically distributed around the center of the microplate (1), a calibration sleeve (232) being provided in the cavity of the bracket (21) and being in contact with the outer circumferential surface of the calibration rod (231), and when the calibration rod (231) is inserted into the calibration sleeve (232), the microplate (1) is located in the center of the bracket (21).

2. The microbial resistance tester according to claim 1, characterized in that: The vibration mechanism (22) comprises a rotating shaft (221), the rotating shaft (221) being rotatably connected to the interior of the cavity of the bracket (21), an eccentric wheel (222) being fixedly connected to the circumferential outer surface of the rotating shaft (221), and a driven gear (223) being fixedly connected to one end of the rotating shaft (221) close to the electric slide rail; The bracket (21) is slidably connected to a guide plate (225) via a guide hole (224) provided on its upper surface, and a contact plate (226) that fits the circumferential outer surface of the eccentric wheel (222) is fixedly connected to the top of the guide plate (225). The guide plate (225) is connected to the top of the bracket (21) via a return spring (227) provided on its lower surface.

3. The microplate reader suitable for microbial drug resistance test according to claim 1, characterized in that: A driving motor (228) is fixedly connected inside the bracket (21) on one side close to the electric slide rail, and a driving gear (229) meshing with the driven gear (223) is fixedly connected to the output end of the driving motor (228).

4. The microplate reader suitable for microbial drug resistance testing according to claim 1, characterized in that: The microporous plate (1) comprises a frame and a plate body, wherein the plate body is connected to the inner wall of the frame via an elastic member arranged on its side wall, and micropores for containing microorganism drug resistance test samples are provided on the upper surface of the plate body.

5. The microplate reader suitable for microbial drug resistance test according to claim 1, characterized in that: The correction rod (231) comprises a plug-in rod (2311), the top end of the plug-in rod (2311) being detachably mounted on the bottom end of the frame, and the plug-in rod (2311) being fixedly connected to a counterweight block (2313) via a mounting groove (2312) provided on the outer circumferential surface thereof.

6. The microplate reader suitable for microbial drug resistance test according to claim 1, characterized in that: The correction sleeve (232) comprises a plug-in sleeve (2321), the circumferential outer surface of the plug-in sleeve (2321) being detachably mounted in the cavity of the bracket (21), the circumferential outer surface of the plug-in sleeve (2321) being provided with a movable hole (2322), and a movable plate (2323) being rotatably connected in the movable hole (2322), a movable sleeve (2324) being rotatably connected to the circumferential outer surface of the plug-in sleeve (2321) at a side of the movable plate (2323) away from the central axis of the plug-in sleeve (2321), and a correction arc plate (2325) being rotatably connected to the top of the plug-in sleeve (2321) and abutting against the top of the movable sleeve (2324).

7. The microplate reader suitable for microbial drug resistance test according to claim 6, characterized in that: The plug-in sleeve (2321) is slidably connected to a movable circular plate (2326) via a guide groove provided on its inner wall, and the movable circular plate (2326) is connected to the inner bottom end of the plug-in sleeve (2321) via a compression spring (2327) provided at its bottom end, and the outer circumferential surface of the movable circular plate (2326) is rotatably connected to a side of the movable plate (2323) close to the central axis of the plug-in sleeve (2321); An electromagnetic block (2328) is fixedly connected to the lower surface of the plug-in sleeve (2321), a side of the movable circular plate (2326) close to the compression spring (2327) is magnetically connected to the electromagnetic block (2328), and a conical space is provided inside the plug-in sleeve (2321).

Images