A dry powder medicament inhaler with a built-in mouthpiece dispersion unit

Abstract

The present invention relates to a dry powder medicament inhaler with a built-in mouthpiece dispersion unit, belonging to the technical field of medical devices. It includes an inhaler body with a mouthpiece, and a dispersion unit is arranged in the mouthpiece. The dispersion unit includes: a first elastic grid and a second elastic grid that define the inlet and outlet of the dispersion unit; a plurality of elastic depolymerization sheets arranged between the first elastic grid and the second elastic grid; a vibration induction structure associated with the end anchors of the elastic depolymerization sheets; the vibration induction structure is configured to be able to generate vibrations in response to a part of the inhaled air flow and transmit the vibrations to the elastic depolymerization sheets through the anchors. The dispersion unit is designed to partially convert the air flow energy generated by the patient's inhalation into mechanical energy and hydrodynamic energy for overcoming the inter-particle forces of the dry powder medicament particles, so as to effectively disperse the dry powder medicament aggregates.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a dry powder inhaler with an in-built mouthpiece dispersion unit. Background Art

[0002] A dry powder inhaler is a dry powder drug delivery device widely used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease. Compared with traditional metered-dose inhalers, dry powder inhalers usually do not contain propellants and rely on the patient's own inspiratory airflow as the driving force to carry a predetermined dose of dry powder drug out of the device and inhale it into the lungs, having advantages such as portability and relatively convenient use.

[0003] During the dry powder drug delivery process, one challenge lies in ensuring that the dry powder drug can reach the deep part of the lungs in the form of sufficiently fine particles (usually with an aerodynamic particle size less than 5 microns) to exert the best therapeutic effect. However, the dry powder micropowder for inhalation therapy itself has a very large specific surface area and surface energy, and there are strong van der Waals forces, electrostatic forces, and possibly liquid bridge forces (when there is moisture) between the particles, resulting in these fine dry powder drug particles being extremely prone to aggregating with each other to form larger aggregates or lumps during production, storage, and especially during the inhalation delivery process. Even for formulations mixed with carriers such as lactose, the dry powder micropowder of the drug needs to effectively detach from the surface of the carrier and depolymerize itself. Summary of the Invention

[0004] To solve the above-mentioned problems in the prior art, the present invention provides a dry powder inhaler with an in-built mouthpiece dispersion unit.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] Provide a dry powder inhaler with an in-built mouthpiece dispersion unit, including an inhaler body with a mouthpiece, and a dispersion unit is arranged in the mouthpiece, and the dispersion unit includes:

[0007] A first elastic grid and a second elastic grid that define the inlet and outlet of the dispersion unit, and the first elastic grid and the second elastic grid allow the airflow and the drug to pass through;

[0008] A plurality of elastic depolymerization sheets arranged between the first elastic grid and the second elastic grid;

[0009] Wherein, at least a part of the elastic depolymerization sheet has a triangular cross-section, and the elastic depolymerization sheet is arranged such that the edge of its triangular cross-section faces the inlet of the dispersion unit;

[0010] A vibration induction structure associated with the end anchor points of the elastic depolymerization sheet;

[0011] Wherein, the vibration induction structure is configured to be able to generate vibration in response to a part of the inhaled air flow, and transmit the vibration to the elastic disintegration sheet through the anchor point, so that the elastic disintegration sheet vibrates during inhalation.

[0012] Preferably, the dispersion unit further includes:

[0013] At least one purge channel;

[0014] Wherein, the purge channel is configured to guide a part of the inhaled air flow to flow tangentially through at least one windward surface of the elastic disintegration sheet.

[0015] Preferably, the purge channel has:

[0016] At least one slit-shaped outlet;

[0017] Wherein, the slit-shaped outlet is arranged adjacent to the windward surface of the elastic disintegration sheet.

[0018] Preferably, the dispersion unit further includes:

[0019] At least one air flow guiding cavity arranged at the anchor point position of the elastic disintegration sheet;

[0020] Wherein, the vibration induction structure is associated with the air flow guiding cavity and generates vibration in the air flow guiding cavity by receiving the part of the inhaled air flow;

[0021] And, the air flow guiding cavity has at least one outlet, and the outlet constitutes the slit-shaped outlet of the purge channel.

[0022] Preferably, the vibration induction structure includes an extension part of the elastic disintegration sheet itself outside the anchor point, and the extension part is configured to flutter under the action of a part of the inhaled air flow.

[0023] Preferably, the extension part has:

[0024] At least one tuning block;

[0025] Wherein, the tuning block is located at the end of the extension part, and the mass of the tuning block is greater than the unit length mass of the main body part of the elastic disintegration sheet.

[0026] Preferably, the end of the extension part has a serrated edge, and the thickness of the area of the serrated edge is less than the thickness of its area near the anchor point.

[0027] Preferably, the first elastic grid defines a plurality of grid openings;

[0028] And, at least a part of the grid openings are arranged obliquely with respect to the central axis of the mouthpiece;

[0029] In the flow direction of the inhalation airflow, the first elastic grid is located upstream of the elastic depolymerization sheet.

[0030] Preferably, the inhaler body includes:

[0031] A cartridge for accommodating a single dose of medicament;

[0032] Wherein, the cartridge has a medicament outlet channel, and the medicament outlet channel communicates with the mouthpiece;

[0033] And, at least one main airflow cavity is provided on the periphery of the medicament outlet channel, and the main airflow cavity has a main airflow port communicating with the mouthpiece.

[0034] Preferably, the inhaler body includes:

[0035] A medicament release mechanism integrated on the inhaler body and cooperating with the cartridge;

[0036] The medicament release mechanism is used to puncture the single dose of medicament.

[0037] The present invention provides a dry powder medicament inhaler with a built-in mouthpiece dispersion unit. The beneficial effects of the present invention are reflected in:

[0038] A dispersion unit is provided in the internal airflow channel of the mouthpiece. The dispersion unit is designed to partially convert the airflow energy generated by the patient's inhalation into mechanical energy and hydrodynamic energy for overcoming the interaction force between dry powder medicament particles, thereby effectively dispersing the dry powder medicament aggregates. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 Is a perspective view of the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention;

[0040] Figure 2 Is a cross-sectional view of the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention;

[0041] Figure 3 Is a perspective view of the first elastic grid in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention;

[0042] Figure 4 Is a perspective view of the elastic depolymerization sheet in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention;

[0043] Figure 5 Is a schematic structural view of the dispersion unit in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention;

[0044] Figure 6 Schematic diagram of the structure of the medicine outlet channel and the main air flow port in the dry powder medicine inhaler with a built-in mouthpiece dispersion unit proposed by the present invention.

[0045] Explanation of reference numerals:

[0046] 1. Inhaler body; 2. Mouthpiece; 3. Dispersion unit; 301. First elastic grid; 302. Second elastic grid; 303. Elastic depolymerization sheet; 3031. Windward surface; 3041. Slit-shaped outlet; 305. Anchor point; 306. Air flow guiding cavity; 4. Vibration induction structure; 401. Extension part; 402. Tuning block; 5. Single-dose medicine; 6. Bin body; 601. Medicine outlet channel; 7. Main air flow cavity; 701. Main air flow port; 8. Medicine release mechanism. Detailed implementation manners

[0047] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0048] Please refer to Figures 1-6 As shown, the specific embodiments provided by the present invention are as follows:

[0049] As Figures 1 to 2 As shown, this embodiment provides a dry powder medicine inhaler with a built-in mouthpiece 2 dispersion unit 3. This inhaler is used to deliver dry powder medicine to the patient's respiratory tract, especially deep into the lungs, to treat respiratory diseases such as asthma or chronic obstructive pulmonary disease.

[0050] The inhaler includes an inhaler body 1 and a mouthpiece 2. The inhaler body 1 constitutes the main part of the device, and its overall shape can be various shapes convenient for holding and operating, such as a flat oval cylinder, a cylinder, or a specific holding area with an ergonomic curve. This body is preferably made of one or more rigid medical-grade plastics through processes such as injection molding to provide sufficient structural strength and stability.

[0051] On the outer surface of the inhaler body 1, structures for internal mechanism linkage or display are provided.

[0052] For example, it includes the installation position or opening of an operation button or slider for starting dose preparation or release, or a transparent window for observing the remaining dose. One end of the inhaler body 1 is formed as a mating interface specifically for connecting with the mouthpiece 2.

[0053] The mouthpiece 2 is the part for the patient to directly contact and inhale the dry powder medicine from. The mouthpiece 2 is generally tubular, or in the shape of a flat duckbill for better fitting the oral cavity. One end (the connecting end) of the mouthpiece 2 has a connecting structure matching the mating interface of the inhaler body 1, which can be, for example, a snap structure or a threaded structure, so that the mouthpiece 2 can be conveniently installed on or removed from the inhaler body 1.

[0054] Of course, the mouthpiece 2 can also be integrally formed with the body. The mouthpiece 2 is preferably made of a smooth and biocompatible medical-grade plastic. Its other end (the inhalation end) is formed into a nozzle part with a specific contour for the patient to easily hold in the mouth and finally leads to a dry powder medicine outlet, and the shape of this outlet can be circular, oval or other shapes suitable for the injection of dry powder medicine.

[0055] Inside the mouthpiece 2, a central air flow channel is defined. The central air flow channel connects the air flow inlet (carrying the dry powder medicine) from the inhaler body 1 to the final dry powder medicine outlet. In addition, the outside of the mouthpiece 2 can optionally be equipped with a protective cover for covering the nozzle part when not in use to keep it clean and hygienic.

[0056] In this embodiment, a dispersion unit 3 is provided in the central air flow channel of the mouthpiece 2. The dispersion unit 3 is designed to partially convert the air flow energy generated by the patient's inhalation into mechanical energy and hydrodynamic energy for overcoming the interaction force between dry powder medicine particles, so as to effectively disperse the dry powder medicine aggregates.

[0057] As Figures 2 to 5 shown, specifically, the inlet and outlet of the dispersion unit 3 are clearly defined by a first elastic grid 301 and a second elastic grid 302. The first elastic grid 301 and the second elastic grid 302 are preferably made of an elastic material with good biocompatibility and resilience, and both themselves present a porous network structure, ensuring that the main air flow and dry powder medicine particles can pass through with a relatively low resistance, and at the same time forming the upper and lower boundaries of the core depolymerization region. And the elastic characteristics of both also allow them to have a certain passive response to air flow pulsation.

[0058] As Figures 2 to 5 shown, between the first elastic grid 301 and the second elastic grid 302 is the core space where the depolymerization occurs, in which several independent elastic depolymerization sheets 303 are arranged. The elastic depolymerization sheet 303 is also made of an elastic material and has flexibility and fatigue resistance.

[0059] In addition, on the basis described above, the elastic depolymerization sheet 303 has a triangular cross-section. During installation, the elastic depolymerization sheet 303 is positioned such that one sharp edge of its triangular cross-section faces the inlet of the dispersion unit 3, directly facing the oncoming airflow carrying the dry powder medicament. The sharp edge is designed to generate an initial and concentrated interaction with the oncoming airflow and the dry powder medicament aggregates therein, including physical cutting, inducing airflow separation, or generating specific local vortices. The two inclined sides constituting the edge, i.e., the windward surface 3031, guide the airflow and particles and provide the main interaction surface.

[0060] Specifically, when the dry powder medicament (especially the larger medicament aggregates therein) moves with the main airflow and collides with the two inclined windward surfaces 3031 of the elastic depolymerization sheet 303, at the moment of collision, the kinetic energy carried by the medicament aggregates is transferred to the particles constituting the aggregates and their connection structures. When the impact energy is sufficient to overcome the binding forces between the particles (such as van der Waals forces, electrostatic forces), it will cause the structure of the aggregates to be damaged or fragmented, directly decomposing them into several smaller units or individual particles.

[0061] In addition, since the windward surface 3031 is inclined rather than a plane perpendicular to the oncoming airflow direction, this collision is closer to an oblique impact. This causes the dry powder medicament particles or the fragmented aggregates after fragmentation to change their original movement trajectories after the collision, being directed sideways or continuing to move downstream at different angles, rather than simply rebounding vertically. This deflection and scattering helps to initially disperse the originally concentrated medicament aggregates in space, increasing the surface area for the subsequent airflow to act on them and potentially reducing the probability of the particles colliding and aggregating again within a short distance downstream.

[0062] In a specific embodiment, in order to drive these elastic depolymerization sheets 303 to perform effective depolymerization work, their two ends are firmly fixed to the cavity wall of the dispersion unit 3 or the edges of the first elastic grid 301 and the second elastic grid 302 through anchor points 305 (which should be understood as a fixed connection point). And, at or in a position closely associated with these end anchor points 305, a vibration induction structure 4 is provided.

[0063] Specifically, the vibration induction structure 4 is used to utilize the energy of a part of the inhaled airflow guided here. When the patient inhales, a part of the airflow drives the vibration induction structure 4, causing it to generate tiny mechanical vibrations. Since the elastic depolymerization sheet 303 is fixedly connected to the vibration induction structure 4, the vibration energy generated by the vibration induction structure 4 can be efficiently and directly transferred to the elastic depolymerization sheet 303.

[0064] Therefore, during the entire inhalation period, the elastic disintegration sheet 303 with a triangular cross-section will passively receive the drive from the anchor point 305 and accordingly undergo continuous minute vibrations along its length. When the airflow carrying the dry powder medicament aggregates enters the area formed by multiple elastic disintegration sheets 303 through the first elastic grid 301, it will undergo repeated and multi-angle mechanical collisions with the elastically vibrating sheets. As a result, the dry powder medicament aggregates are effectively broken up and disintegrated into fine particles suitable for lung deposition, and then leave the dispersion unit 3 with the main airflow through the second elastic grid 302 and are finally inhaled by the patient.

[0065] In a specific embodiment, after each elastic disintegration sheet 303 is fixedly connected to the cavity wall of the dispersion unit 3 or the first elastic grid 301 and the second elastic grid 302 through its end anchor point 305, its structure does not terminate but continues to extend outward integrally, forming a cantilevered extension part 401. This extension part 401 and the main body of the elastic disintegration sheet 303 are made of the same medical-grade elastic material with specific elastic modulus and damping characteristics.

[0066] To drive this extension part 401, an airflow guiding cavity 306 is provided inside the inhaler body 1 or in the dispersion unit 3. When the patient inhales, this airflow guiding cavity 306 captures a part of the inhaled airflow and guides it to the area where these extension parts 401 are located, so that the airflow acts on it at a preset angle and speed.

[0067] When the airflow speed acting on the extension part 401 reaches its flutter critical speed, due to the coupling effect among the fluid force, elastic force and inertial force, this extension part 401 will enter the aeroelastic flutter state, manifested as continuous and rapid reciprocating vibrations.

[0068] The vibrations generated by this extension part 401 are transmitted through the root part where it is connected to the main body of the elastic disintegration sheet 303 and the anchor point 305 area. The structure of this connection area is configured to be conducive to the effective transmission of vibration energy and minimize damping losses. For example, it has a flexible neck or transition section with a lower stiffness. Therefore, the flutter motion of the extension part 401 can drive the main body part of the elastic disintegration sheet 303 to vibrate accordingly, and then disperse the dry powder medicament aggregates passing through the dispersion unit 3.

[0069] Among them, at least one tuning block 402 is integrally or additionally provided at the free end of this extension part 401, that is, the farthest end that extends cantilevered away from the anchor point 305, so as to make the extension part 401 have a concentrated mass.

[0070] Specifically, the end region of the extension portion 401 can be set to be thicker and wider than its root or middle part to form a geometric mass concentration area; alternatively, during manufacturing, through processes such as two-color injection molding and insert molding, the end tuning block 402 part can be made of another biocompatible material with a density higher than the elastic material used for the main body of the extension portion 401; or, the effective mass of the tuning block 402 is greater than the unit length mass of the main body part of the elastic depolymerization sheet 303, so as to ensure the formation of an effective inertial load.

[0071] Based on this, the extension portion 401 is more easily excited by a lower-speed air flow and is more likely to couple with the aerodynamic force to generate flutter, thereby reducing the critical suction air flow velocity at which flutter occurs. This means that even if the patient's inhalation force is slightly weak, the vibration can be more reliably excited.

[0072] In another embodiment, the free end of the extension portion 401 of the elastic depolymerization sheet 303 is not a smooth or straight edge, but is configured to have a serrated edge. Such a serrated edge can be embodied as a series of tiny tooth-like protrusions with a specific profile arranged along the end edge, such as triangular teeth, square teeth, or wavy teeth. The presence of these serrations changes the way the air flow peels off from the surface of the extension portion 401 to promote its flutter behavior.

[0073] At the same time, this embodiment also defines that the thickness of the end region of the extension portion 401 including the serrated edge is less than the thickness of the extension portion 401 near its root (i.e., the position near the anchor point 305 region). That is to say, the serrated edge presents a thickness distribution that gradually thins from the root to the tip. Thus, the reduced thickness makes the end of the extension portion 401 softer and its ability to resist bending deformation decreases, making it more sensitive to the action of the air flow, which helps to reduce the critical air flow velocity at which flutter occurs and enables vibration to be initiated under weaker inhalation conditions.

[0074] In another embodiment, in order to address the problem that dry powder medicament may deposit or adhere inside the dispersion unit 3 during use, thereby affecting the dosing accuracy and long-term use performance, in this embodiment, the dispersion unit 3 further includes at least one purge channel.

[0075] The purge channel is a specific airflow path integrated into the cavity (such as the side wall) of the dispersion unit 3. It is connected to the suction airflow source (such as the aforementioned airflow guiding cavity 306) through an internal pipe. When the patient inhales, a part of the inhaled airflow is guided into the purge channel. Among them, the inhaled airflow blows onto at least one windward surface 3031 of the elastic disintegration sheet 303 (that is, the two inclined surfaces facing the inlet of the dispersion unit 3 in the triangular cross-section) in a manner that is substantially parallel to the surface of the elastic disintegration sheet 303 and tangential. This tangential purge airflow forms a continuously flowing weak air film or air curtain near the windward surface 3031 of the elastic disintegration sheet 303. For a small number of already attached or about-to-be-attached particles, this tangential airflow close to the surface can effectively strip or blow them away, enabling them to re-enter the mainstream airflow or be carried out of the device.

[0076] As Figure 5 shown, additionally, in a specific embodiment, the outlet of the purge channel is preferably at least one slit-shaped outlet 3041. The slit-shaped outlet 3041 can generate a flat and uniform airflow, and its position is set next to the windward surface 3031 of the elastic disintegration sheet 303, ensuring that the purge airflow can effectively cover the target surface area.

[0077] In some embodiments, the function of the purge channel can be achieved through the outlet of the airflow guiding cavity 306. That is, the airflow used to drive the vibration-induced structure 4, after leaving the airflow guiding cavity 306, directly discharges from the position that constitutes the slit-shaped outlet 3041 of the purge channel, realizing the reuse of the airflow and the integration of functions.

[0078] In other embodiments, it is also possible to consider using a row of tiny, directionally arranged spray holes to replace a single slit, covering the surface through the combination of multiple small air jets. The edges of the outlet can be chamfered or specially shaped to reduce airflow separation and make the ejected airflow more stably attached to the surface of the elastic sheet and flow.

[0079] In summary, by adding a purge channel in the dispersion unit 3 and using a part of the inhaled airflow to continuously tangentially purge the surface of the elastic disintegration sheet 303, the drug residue can be significantly reduced, keeping the disintegration element clean and in an efficient working state, thereby improving the accuracy, consistency, and effectiveness of the entire inhaler's delivered dose.

[0080] In a specific embodiment, the first elastic grid 301 located at the entrance of the dispersion unit 3 is made of an elastic material and defines a plurality of grid openings for the passage of air flow and dry powder medicament. And at least a part of these grid openings, preferably most or all of them, do not penetrate perpendicularly to the grid plane, but are inclined with respect to the central axis of the mouthpiece 2 or the main air flow channel (i.e., the general inhalation air flow direction). This inclination can be achieved in various ways. For example, the channel walls of the grid openings themselves are inclined, or the grid bars forming the grid are inclined.

[0081] Furthermore, the grid can be divided into different regions, and the openings in each region have specific and uniform inclination angles and directions, but the angles / directions between regions are different.

[0082] Alternatively, the inclination directions of all the openings point to the center or to the outer periphery to produce a converging or diverging air flow effect.

[0083] Alternatively, the inclination directions of the openings are arranged tangentially to induce an overall swirling air flow (vortex flow) downstream.

[0084] Thus, the air flow jets ejected from different angles and directions will interact, mix, and shear with each other, thereby generating a stronger and more complex turbulent flow field at the entrance of the region where the elastic depolymerization sheet 303 is located than that of a straight-hole grid, which helps to perform preliminary dispersion before the dry powder medicament contacts the elastic sheet.

[0085] Moreover, through a specific inclined arrangement (such as generating a vortex flow), the overall air flow pattern entering the core region can be shaped so that it can interact more effectively with the vibrating elastic depolymerization sheet 303, improving the depolymerization efficiency or the distribution of particles in the cavity.

[0086] In this embodiment, in order to adapt to the use of a single-dose medicament 5 (such as dry powder medicament pre-filled in a capsule), a chamber 6 is provided inside the inhaler body 1. The size and shape of this chamber 6 are used to accommodate and position a single-dose medicament unit, such as a standard inhalation capsule. The chamber 6 is usually equipped with corresponding mechanisms (such as a movable lid or drawer structure not shown in the figure) to facilitate the user to load or remove the single-dose medicament 5 unit.

[0087] As Figure 1 , Figure 2 and Figure 6 shown, a medicament outlet channel 601 is led out from the top of the chamber 6. This medicament outlet channel 601 is the only path for the drug powder to leave the chamber 6 and be guided to the mouthpiece 2 after the medicament unit is activated (such as the capsule is punctured). The end of this medicament outlet channel 601 is communicated with the connecting end of the mouthpiece 2.

[0088] Around the peripheral side (circumferential side) of the medicament outlet passage 601, at least one (usually two symmetrically arranged or forming a ring) main air flow cavity 7 is further provided within the inhaler body 1. The main air flow cavity 7 occupies a part of the internal space outside the medicament outlet passage 601 and communicates with the main air inlet provided outside the inhaler body 1. This means that when the patient inhales, the main inhaled air flow passes through the main air flow cavity 7 instead of directly passing through the cartridge 6 where the medicament is located.

[0089] Each main air flow cavity 7 also has a main air flow port 701 leading to the mouthpiece 2. The main air flow port 701 also communicates with the connecting end of the mouthpiece 2.

[0090] Preferably, the main air flow port 701 is inclined towards the medicament outlet passage 601.

[0091] Separate the medicament outlet passage 601 and the main air flow port 701 within the inhaler body 1 so that the main inhaled air flow can maintain a relatively high flow rate and energy, for effectively mixing, impinging and preliminarily dispersing with the dry powder medicament flow sucked out from the medicament outlet passage 601 at the entrance of the mouthpiece 2, and then entering the dispersion unit 3 provided downstream within the mouthpiece 2 for further processing together.

[0092] In order to effectively release the single-dose medicament 5 (usually referring to a medicament capsule in this embodiment) accommodated in the cartridge 6 during use, the inhaler body 1 further includes a medicament release mechanism 8 that functions in cooperation with and is integrated thereon.

[0093] The medicament release mechanism 8 is used to pierce the outer shell (such as the capsule wall) of the single-dose medicament 5 so that the internal dry powder medicament can flow out smoothly during subsequent inhalation.

[0094] In a specific embodiment, the medicament release mechanism 8 includes the following structure:

[0095] At least one (usually two or more, such as symmetrically arranged on both sides of the capsule) sharp needle provided at the side or end of the cartridge 6. The needle is mounted on a movable bracket and is connected to a user operation button provided on the outer shell of the inhaler body 1 through a mechanical structure such as an internal link or a cam.

[0096] In the initial state or after loading a new single-dose medicament 5, the lancet is in a retracted position away from the interior of the cartridge body 6. When the user needs to inhale the drug and presses the operation button, the operating force drives the lancet to move towards the center of the cartridge body 6 through the internal transmission mechanism. Its tip penetrates a specific area of the cartridge body 6 (provided with a hole for penetration) and pierces the shell of the single-dose medicament 5 (capsule) placed therein. After piercing, when the button is released or at the end of the button stroke, the lancet will automatically retract (due to the elastic action of the spring) to avoid obstructing the outflow of the dry powder medicament and leave an opening of sufficient size on the capsule wall.

[0097] Through the action of the medicament release mechanism 8, the originally closed single-dose medicament 5 is opened, enabling the dry powder medicament inside it to be carried out of the cartridge body 6 via the medicament outlet channel 601 by the airflow when the patient inhales, and enter the subsequent disaggregation and inhalation process.

[0098] In the description of the embodiments of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "center", "top", "bottom", "top part", "bottom part", "inner", "outer", "inner side", "outer side", etc.

[0099] In the description of the embodiments of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "connected", "joined", "assembled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0100] In the description of the embodiments of the present invention, specific features, structures, materials, or characteristics can be combined in a suitable manner in any one or more embodiments or examples.

[0101] In the description of the embodiments of the present invention, it should be understood that "-" and "~" represent the range between two numerical values, and this range includes the endpoints. For example: "A - B" represents the range greater than or equal to A and less than or equal to B. "A ~ B" represents the range greater than or equal to A and less than or equal to B.

[0102] In the description of the embodiments of the present invention, the term "and / or" herein is merely a description of the association relationship of associated objects, indicating that three relationships can exist. For example, A and / or B can represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " herein generally represents an "or" relationship between the associated objects before and after.

[0103] Although embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A dry powder medicament inhaler with a built-in mouthpiece dispersion unit, comprising an inhaler body with a mouthpiece, characterized in that, A dispersion unit is provided inside the mouthpiece, and the dispersion unit includes: a first elastic grid and a second elastic grid that define the inlet and outlet of the dispersion unit, and the first elastic grid and the second elastic grid allow air flow and medicament to pass through; a plurality of elastic depolymerization sheets disposed between the first elastic grid and the second elastic grid; wherein at least a part of the elastic depolymerization sheet has a triangular cross-section, and the elastic depolymerization sheet is arranged such that the edge of its triangular cross-section faces the inlet of the dispersion unit; a vibration induction structure associated with the end anchor points of the elastic depolymerization sheet; wherein the vibration induction structure is configured to be capable of generating vibrations in response to a part of the inhaled air flow and transmitting the vibrations to the elastic depolymerization sheet through the anchor points, so that the elastic depolymerization sheet vibrates during inhalation.

2. The dry powder medicament inhaler with an in-built mouthpiece dispersion unit according to claim 1, characterized in that, The dispersion unit further includes: at least one purge channel; wherein the purge channel is configured to guide a part of the inhaled air flow to flow tangentially through at least one windward surface of the elastic depolymerization sheet.

3. The dry powder medicament inhaler with an in-built mouthpiece dispersion unit according to claim 2, characterized in that, The purge channel has: at least one slit-shaped outlet; wherein the slit-shaped outlet is disposed adjacent to the windward surface of the elastic depolymerization sheet.

4. The dry powder medicament inhaler with a built-in mouthpiece dispersion unit according to claim 3, characterized in that, The dispersion unit further includes: at least one air flow guiding cavity disposed at the anchor point position of the elastic depolymerization sheet; wherein the vibration induction structure is associated with the air flow guiding cavity and generates vibrations in the air flow guiding cavity by receiving the part of the inhaled air flow; and the air flow guiding cavity has at least one outlet, and the outlet constitutes the slit-shaped outlet of the purge channel.

5. The dry powder medicament inhaler with a built-in mouthpiece dispersion unit according to claim 4, wherein the vibration induction structure includes an extension portion of the elastic depolymerization sheet itself outside the anchor points, and the extension portion is configured to flutter under the action of a part of the inhaled air flow.

6. The dry powder medicament inhaler with an in-built mouthpiece dispersion unit according to claim 5, wherein, The extension portion has: at least one tuning block; wherein the tuning block is located at the end of the extension portion, and the mass of the tuning block is greater than the unit length mass of the main body portion of the elastic depolymerization sheet.

7. The dry powder medicament inhaler with an in-built mouthpiece dispersion unit according to claim 5, characterized in that, The end of the extension portion has a serrated edge, and the thickness of the region of the serrated edge is less than the thickness of its region near the anchor point.

8. The dry powder medicament inhaler with a built-in mouthpiece dispersion unit according to claim 1, wherein the first elastic grid defines a plurality of grid openings; and at least a part of the grid openings are inclined with respect to the central axis of the mouthpiece; in the flowing direction of the inhaled air flow, the first elastic grid is located upstream of the elastic depolymerization sheet.

9. The dry powder medicament inhaler having a built-in mouthpiece dispersion unit according to claim 1, characterized in that, The inhaler body includes: a cartridge for accommodating a single dose of medicament; wherein the cartridge has a medicament outlet channel, and the medicament outlet channel is in communication with the mouthpiece; and, at the periphery of the medicament outlet channel, at least one main air flow cavity is provided, and the main air flow cavity has a main air flow port in communication with the mouthpiece.

10. The dry powder medicament inhaler with a built-in mouthpiece dispersion unit according to claim 9, characterized in that, The inhaler body includes: a medicament release mechanism integrated on the inhaler body and cooperating with the cartridge; the medicament release mechanism is used to puncture the single dose of medicament.

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