A disintegration time limit sensing sensor with anti-refraction interference

Abstract

The present invention relates to the field of automatic sensing technology for disintegration time limit, and specifically to a disintegration time limit sensing sensor that is resistant to refraction interference. A disintegration time limit sensing sensor that is resistant to refraction interference comprises: a tube body, a medicine soaking chamber is provided in the tube body; a conical screen cover corresponding to the bottom of the medicine soaking chamber, the upper end diameter of the conical screen cover is larger than the lower end diameter, the lower end of the conical screen cover corresponds to the central position of the medicine soaking chamber and is provided with an opening; a photoelectric sensor, the photoelectric sensor comprises a transmitter and a receiver, the transmitter is fixed under the conical screen cover, and the transmitting port of the transmitter is directly opposite to the opening at the lower end of the conical screen cover; a floating head is placed in the medicine soaking chamber, the receiver is installed in the floating head, and the receiving end of the receiver is exposed at the bottom of the floating head and is directly opposite to the transmitting port of the transmitter. It can effectively prevent the detection accuracy of the photoelectric sensor from being affected by refraction and liquid splashing.

Description

Technical Field

[0001] The present invention relates to the technical field of automatic disintegration time sensing, and in particular to a disintegration time sensing sensor capable of preventing refraction interference. Background Art

[0002] Disintegration refers to the complete disintegration, dissolution, or fragmentation of a solid dosage form within the inspection time limit. Except for insoluble coating materials or broken capsule shells, the dosage form should pass through a 2mm sieve. Disintegration time is determined using a lift-type disintegrator. Standard tablets should completely disintegrate within 15 minutes, hard capsules within 30 minutes, and soft capsules within one hour. Confirmation of disintegration time is typically done visually, which is subject to subjective error and consumes time.

[0003] In order to reduce labor costs and avoid errors in manual inspection, underwater photoelectric sensors can be used to monitor the disintegration time of drugs. However, there are the following manifestations of poor stability:

[0004] On the one hand, during the disintegration operation, the tube body needs to move up and down, which means that the receiver of the photoelectric sensor may be placed above the liquid surface. In this case, the light signal from the transmitter needs to pass through the solution and air to be received by the receiver. During this process, refraction occurs, resulting in the receiver not being able to receive the light signal in time.

[0005] On the other hand, when the tube moves up and down, the solution in the tube will shake, causing the solution in the tube to splash, thereby interfering with the accuracy of the receiver receiving the optical signal. Summary of the Invention

[0006] In order to overcome the above-mentioned deficiencies of the prior art, the present application provides a disintegration time limit sensing sensor that is resistant to refraction interference, which can effectively prevent the detection accuracy of the photoelectric sensor from being affected by refraction and liquid splashing.

[0007] In order to achieve the above object, the present invention is implemented through the following technical solution: a disintegration time limit sensing sensor with anti-refraction interference, comprising:

[0008] A tube body, wherein a medicine soaking cavity is provided in the tube body;

[0009] A conical screen cover corresponding to the bottom of the medicine soaking chamber, wherein the upper end diameter of the conical screen cover is larger than the lower end diameter, and the lower end of the conical screen cover corresponds to the central position of the medicine soaking chamber and is provided with an opening;

[0010] The photoelectric sensor includes a transmitter and a receiver. The transmitter is fixed below the conical screen cover, and the transmitting port of the transmitter is directly opposite to the opening at the lower end of the conical screen cover.

[0011] The floating head is placed in the medicine soaking chamber, and the receiver is installed in the floating head. The receiving end of the receiver is exposed at the bottom of the floating head and is opposite to the transmitting port of the transmitter.

[0012] Furthermore, a disintegration time limit sensing sensor with anti-refraction interference in the present application also includes a transmitter mounting bracket, which is connected to the lower end of the tube body. The transmitter mounting bracket includes a base, and a mounting countersunk hole is provided at the bottom of the base. The transmitter end is arranged in the mounting countersunk hole, and a light-transmitting through-hole corresponding to the emission port of the transmitter is penetrated at the top of the mounting countersunk hole.

[0013] Furthermore, in the present application, a disintegration time limit induction sensor with anti-refraction interference is provided with a conical fitting surface at the upper end of the base, and the lower end of the conical bottom surface of the conical screen cover is fitted with the conical fitting surface.

[0014] Furthermore, in the present application, a disintegration time limit induction sensor with anti-refraction interference, the conical screen cover includes a conical bottom and an annular sleeve connected in one piece, the conical bottom is arranged below the annular sleeve, and the annular sleeve is arranged on the outer wall of the tube body;

[0015] The launcher mounting bracket also includes a ring, which is arranged above the base. A group of connecting plates are circumferentially provided at the lower end of the ring. The bottom of the connecting plate is connected to the base. A limiting groove is provided on the inner wall of the ring. The top of the annular sleeve is arranged in the limiting groove on the inner wall of the ring. The ring is sleeved on the outer wall of the tube body.

[0016] Furthermore, in the present application, a disintegration time limit sensing sensor with anti-refraction interference is provided, wherein the radial dimension of the floating head is adapted to the radial dimension of the medicine soaking chamber.

[0017] Furthermore, in the present application, a disintegration time limit sensing sensor that is resistant to refraction interference is provided with a set of notches that pass through from top to bottom on the side wall of the floating head.

[0018] It can be seen from the above technical solution that the present invention has the following beneficial effects:

[0019] Based on the above device, the disintegration time limit sensing sensor with anti-refraction interference in the present application, when performing the disintegration operation, the medicine is placed in the medicine immersion chamber, the tube body is immersed in the solvent and moved up and down by external drive, the solvent penetrates into the medicine immersion chamber from the mesh of the conical screen cover to dissolve the medicine, in this process, the floating head floats on the solvent in the medicine immersion chamber, the medicine is between the transmitter and the receiver, and the receiving end of the receiver is always immersed in the liquid surface. Therefore, the disintegration time limit sensing sensor with anti-refraction interference in the present application, on the one hand, due to the setting of the floating head, can ensure that the receiving end of the receiver is always immersed in the solvent, so that it can ensure that the light signal emitted by the transmitter to the receiver is only transmitted in the solvent, so that the light signal will not be affected by refraction interference due to the oscillation of the water surface, resulting in the receiver being unable to receive the signal in time; on the other hand, because the floating head floats on the solvent in the medicine immersion chamber, it can slow down the bubbles generated by the splashing of the solvent liquid surface in the medicine immersion chamber caused by the up and down movement of the tube body, so as to ensure the accuracy of detecting the end point of the disintegration time limit. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the three-dimensional structure of a disintegration time endpoint timing device according to one embodiment of the present application;

[0021] Figure 2 is a structural schematic diagram of the lifting drive device;

[0022] Figure 3 This is a schematic diagram of the installation of a Hall sensor and an induction magnetic block in a disintegration time endpoint timing device according to one embodiment of the present application;

[0023] Figure 4 is a schematic diagram of the three-dimensional structure of the hanging basket;

[0024] Figure 5 An exploded view of the components of the hanging basket;

[0025] Figure 6 is a cross-sectional view of the hanging basket;

[0026] Figure 7 for Figure 6 A partial enlarged view of area A in the middle circle.

[0027] In the picture:

[0028] 1- Disintegration Apparatus Body; 11- Water Bath; 12- Lifting Drive; 121- Rotating Transmission; 122- Linear Motion Assembly; 123- Inductive Magnetic Block; 124- Lifting Rod; 125- Extension Plate; 126- Hanging Rod; 13- Hall Effect Sensor;

[0029] 2-basket; 21-tube body; 22-conical screen cover; 221-conical bottom; 222-annular sleeve; 23-upper limit plate; 24-lower limit plate; 25-connecting rod; 251-positioning nut; 252-wire trough; 253-limiting cap; 254-mounting plate; 255-wire through hole; 26-support plate;

[0030] 3-beaker;

[0031] 4-photoelectric sensor; 41-transmitter; 42-receiver; 421-floating head; 422-missing part;

[0032] 5-emitter mounting frame; 51-base; 511-mounting countersunk hole; 512-light-transmitting through hole; 513-conical fitting surface; 5134-limiting platform; 52-ring; 53-connecting plate. DETAILED DESCRIPTION

[0033] Example 1

[0034] Combine Figures 5 to 7 A disintegration time limit sensing sensor with anti-refraction interference is shown, comprising:

[0035] The pipe body 21 is provided with a chemical soaking chamber;

[0036] A conical screen cover 22 corresponding to the bottom of the medicine soaking chamber, wherein the upper end diameter of the conical screen cover 22 is larger than the lower end diameter, and the lower end of the conical screen cover 22 corresponds to the central position of the medicine soaking chamber and is provided with an opening;

[0037] Photoelectric sensor 4, the photoelectric sensor 4 includes a transmitter 41 and a receiver 42, the transmitter 41 is fixed below the conical screen cover 22, and the emission port of the transmitter 41 is directly opposite to the opening at the lower end of the conical screen cover 22;

[0038] The floating head 421 is placed in the medicine soaking chamber, and the receiver 42 is installed in the floating head 421. The receiving end of the receiver 42 is exposed at the bottom of the floating head 421 and is opposite to the launching port of the launcher 41.

[0039] The principle of the above-mentioned sensor for monitoring the disintegration time limit is as follows: the drug placed in the tube body 21 sinks to the bottom of the tube body 21. Due to the setting of the conical screen cover 22, the drug will automatically occupy the center position of the conical screen cover 22 due to gravity, and at this time, it just blocks the launch port of the transmitter 41. During the disintegration experiment, when the hanging basket 2 moves upward, the drug will fit with the conical screen cover 22, and at this time, it can ensure that the undisintegrated drug blocks the launch port of the transmitter 41, so that the receiver 42 cannot detect the light signal emitted by the transmitter 41; when the drug is completely disintegrated, there is no obstruction between the transmitter 41 and the receiver 42, and the receiver 42 can receive the light signal, thereby starting to stop timing, outputting timing data, and obtaining the disintegration time limit end time. It should be noted that the reciprocating frequency of the hanging basket 2 up and down movement specified in the Pharmacopoeia is 30 to 32 times per minute, so the theoretical error of the disintegration time limit timing of the disintegration time limit timing device of this embodiment is 1 second. Therefore, the disintegration endpoint timing device of this embodiment can automatically time the disintegration endpoint of the drug to be tested, saving manpower. Compared with existing technical solutions for automatic detection of the disintegration endpoint, it has the advantages of low manufacturing cost, simple control principle, and good reliability. Among them, the photoelectric sensor 4 is preferably an underwater infrared photoelectric sensor.

[0040] In this embodiment, on the one hand, due to the setting of the floating head 421, it can be ensured that the receiving end of the receiver 42 is always immersed in the solvent, so that the optical signal emitted by the transmitter 41 to the receiver 42 is only transmitted in the solvent, so the optical signal will not be refracted and disturbed due to the vibration of the water surface, resulting in the receiver 42 being unable to receive the signal in time; on the other hand, since the floating head 421 floats on the solvent in the immersion chamber, it can slow down the bubbles generated by the splashing of the solvent liquid surface in the immersion chamber due to the up and down movement of the tube body 21, so as to ensure the accuracy of detecting the end point of the disintegration time limit.

[0041] Specifically, in this embodiment, the positions of the receiving port and the transmitting port of the receiver 42 and the transmitter 41 correspond to the axis of the tube body 21 .

[0042] In this embodiment, a transmitter mounting frame 5 is also included. The transmitter mounting frame 5 is installed at the lower end of the tube body 21. The transmitter mounting frame 5 is connected to the tube body 21. The transmitter mounting frame 5 includes a base 51. A mounting countersunk hole 511 is provided at the bottom of the base 51. The transmitting end of the transmitter 41 is arranged in the mounting countersunk hole 511. A light-transmitting perforation 512 is provided at the top of the mounting countersunk hole 511. The light-transmitting perforation 512 corresponds to the transmitting port of the transmitter 41. The aperture of the light-transmitting perforation 512 is less than or equal to the sieve hole of the conical screen cover 22. The aperture size of the sieve hole of the disintegration instrument is the size specified in the "Pharmacopoeia", such as 2mm. When the particles after the drug disintegration are smaller than the sieve hole of the conical screen cover 22, the disintegration is considered to be complete. Therefore, the light-transmitting perforation 512 is smaller than the sieve hole of the conical screen cover 22, which can ensure that the drug that has not completed disintegration can cover the light-transmitting perforation 512. Light-transmitting through-hole 512 is vertically arranged throughout. Providing light-transmitting through-hole 512 and mounting counterbore 511 prevents diffuse reflection of the light signal emitted by transmitter 41, which could cause receiver 42 to receive the light signal prematurely and cause errors. In this embodiment, mounting counterbore 511 is threadedly connected to transmitter 41, and light-transmitting through-hole 512 corresponds to the axial core of tube body 21.

[0043] Combine Figure 7 As shown, in this embodiment, a conical fitting surface 513 is provided at the upper end of the base 51. The lower end of the conical bottom surface of the conical screen cover 22 fits with the conical fitting surface 513. A stopper 5134 extends from the center of the conical fitting surface 513. The edge of the opening at the lower end of the conical screen cover 22 fits with the stopper 5134. In this embodiment, the launcher mounting frame 5 also includes a collar 52, which is arranged above the base 51. A group of connecting plates 53 are circumferentially provided at the lower end of the collar 52. The bottom of the connecting plate 53 is connected to the base 51, and the collar 52 is sleeved on the outer wall of the tube body 21. The collar 52 and the base 51 are connected by the connecting plate 53. The launcher mounting frame 5 is hollowed out as a whole, which can ensure the circulation of the solvent.

[0044] Combine Figure 5As shown, in this embodiment, the conical screen cover 22 includes an integrally connected conical bottom 221 and an annular sleeve 222. The conical bottom 221 is disposed below the annular sleeve 222, and the annular sleeve 222 is sleeved on the outer wall of the tube body 21. The conical surface on the inner side of the conical bottom 221 fits against the bottom of the tube body 21, thereby limiting the position of the conical screen cover 22 relative to the tube body 21. When the conical bottom 221 is separated from the bottom edge of the tube body 21, the annular sleeve 222 can prevent a gap from forming between the conical screen cover 22 and the tube body 21, so that the medicine inside the tube body 21 can leak out through the gap. In this embodiment, a limiting groove is provided on the inner wall of the ring 52, and the top of the annular sleeve 222 is arranged in the limiting groove on the inner wall of the ring 52. Therefore, in this embodiment, the conical screen cover 22 is embedded as a whole between the ring 52 and the conical fitting surface 513 of the launcher mounting frame 5. The overall fixing effect is firm, and when the hanging basket 2 reciprocates up and down, the conical screen cover 22 can be effectively prevented from falling off relative to the launcher mounting frame 5.

[0045] Furthermore, in this embodiment, the radial dimensions of the floating head 421 are adapted to those of the drug immersion chamber. This ensures that the receiver 42 always faces the transmitter 41 during movement of the floating head 421. Furthermore, a series of vertically extending notches 422 are provided on the sidewalls of the floating head 421. These notches 422 prevent the floating head 421 from causing airtight blockage of the tube body 21.

[0046] Example 2

[0047] Combine Figures 1 to 5 The disintegration time endpoint timing device shown includes a disintegration instrument body 1, which includes a water bath 11 and a lifting drive device 12, as well as a beaker 3 and a hanging basket 2. The beaker 3 is disposed in the water bath 11, and the hanging basket 2 is disposed in the beaker 3. The lifting drive device 12 can drive the hanging basket 2 to reciprocate up and down in the beaker 3; a disintegration time limit sensing sensor with anti-refraction interference in a set of embodiment 1 is installed on the hanging basket 2, and a transmitter 41 and a receiver 42 are electrically connected to the disintegration instrument control system;

[0048] The lifting drive device 12 includes a rotating transmission member 121 and a linear motion component 122. The rotating transmission member 121 is in transmission connection with the linear motion component 122, and the linear motion component 122 is connected to the hanging basket 2. The rotating transmission member 121 is provided with an induction magnetic block 123; and further includes a Hall sensor 13, which is arranged on one side of the induction magnetic block 123 and is electrically connected to the disintegration instrument control system.

[0049] When the rotating transmission member 121 drives the sensing magnet 123 to rotate to a position corresponding to the Hall sensor 13 , the linear moving component 122 is in an upward movement.

[0050] In this embodiment, the number of tubes 21 is 6 and they are evenly spaced in the circumferential direction. A method for using the disintegration time endpoint timing device of this embodiment includes the following steps:

[0051] S1: Preparation: Solvent is placed in the water bath 11 and the beaker 3, the hanging basket 2 is immersed in the beaker 3, and the lifting drive device 12 is connected to the hanging basket 2;

[0052] S2: To begin, the drug to be tested is placed in the tube body 21, the disintegration instrument is started, and the lifting drive device 12 drives the hanging basket 2 to move up and down in the beaker 3. The counting module of the disintegration instrument control system simultaneously performs timing. In order to prevent the drug from moving up and down for too long, a limiting cover (not shown) that can be sunk into the solution in the drug immersion chamber can be provided to cover the drug. The limiting cover is provided with a through hole that is positioned opposite to the emitter 41, and the size of the through hole is the same as the mesh size of the conical screen cover 22.

[0053] S3: Emitting a light signal. When the hanging basket 2 moves upward, the induction magnetic block 123 rotates to a position corresponding to the Hall sensor 13. At this time, the Hall sensor 13 outputs a signal to the controller, and the controller controls the emitter 41 to emit a light signal.

[0054] S4: End point timing. After the drug disintegrates, and there is no obstruction between receiver 42 and transmitter 41, receiver 42 receives the light signal from transmitter 41, and the corresponding counter stops timing and outputs the timing data. The output destination of the timing data includes, but is not limited to, a display screen, a computer, or a printer.

[0055] In this embodiment, the rotating transmission member 121 rotates one circle, the linear moving component 122 completes one lifting, the induction magnetic block 123 is set on the rotating transmission member 121, and the Hall sensor 13 is fixed at a preset position. Since the rotation stroke position of the rotating transmission member 121 and the moving position (including direction parameters) of the linear moving component 122 can correspond one to one, the Hall sensor 13 can be used to detect whether the rotating transmission member 121 rotates to the preset position to determine whether the hanging basket 2 is in an upward moving state. The rotating transmission member 121 can be a cam or a crank, and the cam follower mechanism or the crank slider mechanism is used to achieve the above functions. In this embodiment, the rotating transmission member 121 is an eccentric wheel, and the lower end of the linear moving component 122 is in contact with the upper end of the eccentric wheel.

[0056] Combine Figure 4 and Figure 6As shown, in this embodiment, the hanging basket 2 includes an upper limit plate 23 and a lower limit plate 24. The upper limit plate 23 is set at the upper end of a group of tube bodies 21, and a group of tube bodies 21 are passed through the lower limit plate 24. The upper limit plate 23 and the lower limit plate 24 are provided with limit holes adapted to the tube bodies 21; it also includes a connecting rod 25, which passes through the upper limit plate 23 and the lower limit plate 24. The outer wall of the connecting rod 25 is provided with a group of positioning nuts 251. The positioning nuts 251 realize the axial positioning of the upper limit plate 23 and the lower limit plate 24 relative to the connecting rod 25. The upper end of the connecting rod 25 is connected to the lifting drive device 12. The connecting rod 25 is driven by the lifting drive device 12, thereby realizing the up and down movement of the hanging basket 2 as a whole. It should be noted that the upper end of the limit hole corresponding to the tube body 21 on the upper limit plate 23 is provided with a radially inwardly extending eaves to realize the limiting of the upper end of the tube body 21.

[0057] Combine Figure 6 and Figure 7 As shown, in this embodiment, the connecting rod 25 is a hollow tube with two open ends. The lower end of the connecting rod 25 extends to correspond to the launcher 41. The connecting rod 25, which is a hollow tube, is used to pass a group of wires from the launcher 41 through it to prevent the wires from swinging, entanglement, and interference when the hanging basket 2 moves up and down. In this embodiment, a group of wire grooves 252 are circumferentially provided at the lower end of the connecting rod 25. Each group of wire grooves 252 corresponds to a group of launchers 41. A limit cap 253 is connected to the bottom of the connecting rod 25. The wire grooves 252 are used to lead out the wires, and the limit cap 253 can limit the lower end of the wires.

[0058] Combine Figure 4 As shown, in this embodiment, the hanging basket 2 also includes a support plate 26, which is connected to the lower limit plate 24 via a set of bolts. The upper end of the support plate 26 is in contact with the bottom surface of the base 51. The support plate 26 is fixed to the bottom of the launcher mounting frame 5 using bolts and nuts. This overall structure improves the secure connection between the launcher mounting frame 5 and the conical screen cover 22 relative to the tube body 21. In this embodiment, the top of the collar 52 is in contact with the upper limit plate 23. The entire structure is also removable, making it easy to clean and maintain.

[0059] Combine Figure 1 and Figure 2 As shown, in this embodiment, a mounting plate 254 is provided on the top of the connecting rod 25. The mounting plate 254 is provided with a wire through-hole 255 for passing the wire extending from the receiver 42. The linear motion assembly 122 includes a lifting rod 124, a rotating transmission member 121 extending from the upper end of the disintegration apparatus body 1, and an extension plate 125 on the rotating transmission member 121. A pair of suspension rods 126 are fixed to the linear motion assembly 122, and a pair of induction magnets 123 are connected to the mounting plate 254.

[0060] The technical principles of the present invention have been described above in conjunction with specific embodiments. These descriptions are intended solely to illustrate the principles of the present invention and are not to be construed in any way as limiting the scope of protection of the present invention. Based on the explanations herein, those skilled in the art will be able to conceive of other specific embodiments of the present invention without inventive effort, and such embodiments will fall within the scope of protection of the present invention.

Claims

1. A disintegration time limit induction sensor with anti-refraction interference, characterized in that: include: The pipe body (21) is provided with a chemical dipping chamber; A conical screen cover (22) corresponding to the bottom of the medicine soaking chamber, wherein the upper end diameter of the conical screen cover (22) is larger than the lower end diameter, and the lower end of the conical screen cover (22) corresponds to the central position of the medicine soaking chamber and is provided with an opening; A photoelectric sensor (4), the photoelectric sensor (4) includes a transmitter (41) and a receiver (42), the transmitter (41) is fixed below the conical screen cover (22), and the transmitting port of the transmitter (41) is directly opposite to the opening at the lower end of the conical screen cover (22); A floating head (421) is placed in the medicine soaking chamber, and a receiver (42) is installed in the floating head (421). The receiving end of the receiver (42) is exposed at the bottom of the floating head (421) and is directly opposite to the transmitting port of the transmitter (41).

2. The refraction-interference-resistant disintegration time sensor according to claim 1, characterized in that: The device further comprises a transmitter mounting frame (5), the transmitter mounting frame (5) being connected to the lower end of the tube body (21), the transmitter mounting frame (5) comprising a base (51), a mounting countersunk hole (511) being provided at the bottom of the base (51), an emitting end of the transmitter (41) being arranged in the mounting countersunk hole (511), and a light-transmitting through-hole (512) corresponding to the emitting port of the transmitter (41) being provided at the top of the mounting countersunk hole (511).

3. The refraction-interference-resistant disintegration time sensor according to claim 2, characterized in that: The upper end of the base (51) is provided with a conical fitting surface (513), and the lower end of the conical bottom surface of the conical screen cover (22) fits into the conical fitting surface (513).

4. The refraction-interference-resistant disintegration time sensor according to claim 2, characterized in that: The conical screen cover (22) comprises a conical bottom (221) and an annular sleeve (222) connected in one piece, wherein the conical bottom (221) is arranged below the annular sleeve (222), and the annular sleeve (222) is sleeved on the outer wall of the tube body (21); The launcher mounting frame (5) further comprises a collar (52), the collar (52) being arranged above the base (51), a group of connecting plates (53) being circumferentially provided at the lower end of the collar (52), the bottom of the connecting plate (53) being connected to the base (51), a limiting groove being provided on the inner wall of the collar (52), the top end of the annular sleeve (222) being arranged in the limiting groove on the inner wall of the collar (52), and the collar (52) being sleeved on the outer wall of the tube body (21).

5. The refraction-interference-resistant disintegration time sensor according to claim 1, characterized in that: The radial dimension of the floating head (421) is adapted to the radial dimension of the medicine soaking chamber.

6. The refraction-interference-resistant disintegration time sensor according to claim 5, characterized in that: The side wall of the floating head (421) is provided with a group of notches (422) that pass through from top to bottom.

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