Anti-aging and skin barrier repairing composition, product and application thereof

Abstract

The invention relates to the field of cosmetics, in particular to an anti-aging and skin barrier repairing composition, a product and application thereof. The invention provides an anti-aging and skin barrier repairing composition. The anti-aging and skin barrier repairing composition comprises lactobionic acid, cryptomeria fortunei bud extract and seasoning murraya paniculata stem extract. The lactobionic acid, the cryptomeria fortunei bud extract and the seasoning murraya paniculata stem extract are compounded for use, so that the synergistic interaction effect is achieved, the improvement of COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation can be remarkably promoted, the production of I-type collagen, III-type collagen and elastin is improved, and the obvious anti-wrinkle effect is achieved. In addition, the composition provided by the invention can significantly improve the relative expression quantity of FLG and LOR genes in a human immortalized keratinocyte model, and has the effect of repairing the skin barrier.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to anti-aging and skin barrier repairing compositions, products and applications thereof. Background Art

[0002] Aging is a complex and continuous biological process characterized by cellular and molecular changes, a progressive decrease in the body's ability to maintain homeostasis, and increased apoptosis and senescence, which become more pronounced with the passage of time.

[0003] The two main processes of skin aging are endogenous aging and exogenous aging. Endogenous aging is controlled by the individual's genetics and gradually manifests itself over time. This is an inevitable law; while exogenous aging is mainly caused by environmental factors, such as ultraviolet radiation, smoking, wind, sun exposure, and exposure to harmful chemicals. At the cellular level, skin aging also brings about some functional changes, including decreased proliferation of keratinocytes, reduced stratum corneum formation, decreased ability to regenerate the protective barrier, and reduced lipid synthesis.

[0004] The prior art has disclosed a variety of anti-aging products, such as retinol and retinol derivatives, which have strong anti-aging effects but are highly irritating; peptides and collagen anti-aging substances are mild and effective, but they are expensive and the active ingredients are not stable. Summary of the invention

[0005] In view of this, the present invention provides an anti-aging and skin barrier repair composition, product and application thereof. The composition provided by the present invention has a synergistic effect and can effectively resist aging and repair the skin barrier.

[0006] The invention provides an anti-aging and skin barrier repairing composition, comprising lactobionic acid, cryptomeria fortunei bud extract and condiment osmanthus odoratus stem extract.

[0007] Lactobionic acid is a polyhydroxy biomimetic acid with a molecular formula of C 12 H 22 O 12, the structural formula is shown in formula (I), and it has broad application prospects in the food, pharmaceutical and chemical industries. Lactobionic acid has multiple functions such as moisturizing, repairing, anti-aging and anti-oxidation. For example, lactobionic acid contains eight hydrophilic hydroxyl groups, so it has good hygroscopicity and can bind water in the epidermis. As an effective moisturizer, it softens the skin surface and reduces the appearance of fine wrinkles. For example, lactobionic acid can chelate with metal ions, inhibit the activity of matrix metalloproteinases (MMPs), protect collagen, improve skin elasticity, and effectively reduce the effects of photoaging. Moreover, lactobionic acid has a significant effect on improving the homeostasis of the epidermal barrier and the function of the stratum corneum, but it does not have side effects such as irritation and stinging similar to traditional hydroxy acids (such as glycolic acid), and can act on sensitive skin.

[0008] Formula (I).

[0009] Cryptomeria japonica bud extract, also known as CRYPTOMERIA JAPONICA BUD EXTRACT, is an extract extracted from the tender buds of Cryptomeria japonica and has the following effects: (1) Promote the regeneration of skin tissue structure: Cryptomeria japonica bud extract can stimulate the regeneration of skin cells, enhance the vitality of skin tissue, and help reshape a healthy skin structure.

[0010] (2) Comprehensively strengthen the skin: Cryptomeria japonica bud extract has antioxidant and anti-free radical properties, which can effectively resist the effects of harmful factors in the environment on the skin, thereby comprehensively improving the skin's resistance.

[0011] (3) Create a moist and plump texture: Cryptomeria japonica bud extract contains rich natural moisturizing ingredients that can effectively retain skin moisture, making the skin more hydrated, plump and elastic.

[0012] (4) Forming a barrier to protect the skin: Cryptomeria bud extract can form a protective film on the surface of the skin, effectively blocking external stimuli and pollution, thereby protecting the skin from external damage.

[0013] (5) Anti-allergic: Cryptomeria japonica bud extract has excellent anti-inflammatory and anti-allergic effects. It can effectively relieve skin allergy symptoms, reduce allergic reactions, and make the skin healthier and more comfortable.

[0014] The present application has no particular restrictions on the source of the Cryptomeria fortunei bud extract, and any product purchased on the market can be used. In some specific implementations, the Cryptomeria fortunei bud extract is a commercially available product extracted from water and butylene glycol, and its isopimaric acid content is greater than 150ppm, preferably greater than 170ppm, more preferably greater than 190ppm, and most preferably greater than 200ppm.

[0015] Murraya Koenigii Stem Extract, also known as Murraya Koenigii STEM EXTRACT, is an extract of the stem of Murraya exotica L., a plant of the Rutaceae family. Murraya Koenigii Stem Extract can promote the metabolism of skin cells, accelerate the shedding of old cells and the generation of new cells, and restore the skin's luster and elasticity.

[0016] The present application has no special restrictions on the source of the seasoning Murraya paniculata stem extract, and any product purchased on the market can be used. In some specific implementations, the seasoning Murraya paniculata stem extract is a commercially available product extracted from water, propylene glycol and betaine, and its flavonoid content is greater than 30ppm, preferably greater than 35ppm.

[0017] The inventors found that the combined use of lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya osmanthus stem extract has a synergistic effect, which can significantly promote the increase in COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect.

[0018] In some embodiments of the present invention, the above composition includes, by weight: 0.3-8 parts of lactobionic acid, 0.5-25 parts of Cryptomeria fortunei bud extract, and 0.4-35 parts of Murraya odorifera stem extract.

[0019] In some embodiments of the present invention, the above composition includes, by weight: 0.3-6 parts of lactobionic acid, 0.5-20 parts of Cryptomeria fortunei bud extract and 0.4-30 parts of Murraya osmanthus stem extract.

[0020] In some embodiments of the present invention, the above composition includes, by weight: 0.5-4 parts of lactobionic acid, 1-15 parts of Cryptomeria fortunei bud extract, and 0.5-20 parts of Murraya odorifera stem extract.

[0021] In some embodiments of the present invention, the above composition includes, by weight: 1 to 3 parts of lactobionic acid, 1.5 to 12 parts of Cryptomeria japonica bud extract, and 1 to 15 parts of Murraya odorifera stem extract.

[0022] In some embodiments of the present invention, the above composition, by weight, comprises: 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract and 6 parts of Murraya paniculata stem extract; In some embodiments of the present invention, the above composition, in parts by weight, comprises: 4 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract; In some embodiments of the present invention, the above composition, in parts by weight, comprises: 0.3 parts of lactobionic acid, 0.5 parts of Cryptomeria japonica bud extract and 0.4 parts of Murraya odorifera stem extract; In some embodiments of the present invention, the above composition, in parts by weight, comprises: 1 part of lactobionic acid, 12 parts of Cryptomeria japonica bud extract and 15 parts of Murraya odorifera stem extract; In some embodiments of the present invention, the above composition, by weight, comprises: 6 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract; In some embodiments of the present invention, the above composition, in parts by weight, includes: 2 parts of lactobionic acid, 1.5 parts of Cryptomeria fortunei bud extract and 1 part of Murraya osmanthus stem extract.

[0023] The present invention also provides the use of the above composition in the preparation of anti-aging products. Experimental results show that the combination of lactobionic acid, Cryptomeria japonica bud extract and Murraya oleifera stem extract has a synergistic effect, which can significantly promote the increase of COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect.

[0024] The present invention also provides the use of the above composition in the preparation of repair products. Experimental results show that the combined use of lactobionic acid, Cryptomeria japonica bud extract and condiment Murraya oleifera stem extract can significantly increase the relative expression of FLG and LOR genes in the human immortalized keratinocyte model, and has the effect of repairing the skin barrier.

[0025] The present invention also provides a product, comprising: the anti-aging and skin barrier repairing composition described in the above technical solution.

[0026] In some embodiments of the present invention, the above products include but are not limited to personal care products, medicines, etc. Those skilled in the art can understand that, in addition to the composition described in the above technical solution, other excipients are also included, such as pharmaceutical excipients or excipients for personal care products.

[0027] In some embodiments of the present invention, the personal care product comprises: a basic care product and / or a makeup product.

[0028] In some embodiments of the present invention, the cosmetic products include but are not limited to: (1) Foundation makeup: Liquid foundation / cream: used to even out skin tone and cover blemishes; BB cream / CC cream: a light makeup base product that combines skin care and finishing effects; Concealer / pen: for covering local areas such as acne, dark circles, etc.; Loose powder / face powder: sets makeup and reduces facial shine.

[0029] (2) Eye makeup: Eyeshadow: Add color and depth to the eyes; Eyeliner pencil / liquid / gel: outline the eyeliner to make the eyes look more vivid; Mascara: lengthens and thickens eyelashes, making eyes look deeper; Eyebrow pencil / eyebrow powder / eyebrow gel: fill in the gaps in the eyebrows and shape the ideal eyebrow shape.

[0030] (3) Cheek makeup: Blush: add natural redness to cheeks and improve complexion; Contouring cake / stick: Use shading techniques to make the facial contour more three-dimensional; (4) Lip makeup: Lipstick / Lip Glaze / Lip Gloss: Change or emphasize the color of lips; Lip liner: Draw a clear lip boundary to prevent lipstick from overflowing.

[0031] (5) Multifunctional cosmetics: Highlighter stick / liquid / powder: brightens the high points of the face (such as the bridge of the nose and cheekbones) to create a radiant look.

[0032] In addition, there are products designed specifically for special occasions, such as waterproof and sweat-proof eyeliners, long-lasting lipsticks, etc.

[0033] In some embodiments of the present invention, the basic care products include but are not limited to: Facial cleanser / facial cleanser: gently removes facial dirt, oil and makeup residue; Makeup remover oil / makeup remover water / makeup remover cream: specially used to completely remove makeup, especially waterproof makeup; Toner / make-up water: Use after cleansing to further clean the residue on the skin surface, replenish moisture for the skin, restore the pH balance of the skin, and lay a good foundation for the absorption of subsequent skin care products; Essence: Contains high concentrations of active ingredients, providing deep nourishment and repair for specific skin problems (such as anti-aging, moisturizing, whitening, etc.); Eye cream: specially designed for the sensitive area around the eyes, it can reduce fine lines, dark circles and tighten the skin around the eyes. The texture is usually light and easy to absorb; Day / night lotion or cream: has the functions of protecting, repairing and nourishing, promoting cell regeneration, etc., can provide the skin with necessary moisture and lock in the replenished moisture; Sunscreen: used for UV protection, prevention of photoaging, etc.; Facial masks: provide extra nourishment and care to the skin, such as hydration, pore cleansing or brightening.

[0034] This application adds lactobionic acid, Cryptomeria japonica bud extract and seasoning Murraya osmanthus stem extract to the above-mentioned product for use, which can have the effects of anti-aging and repairing the skin barrier. This application has no special restrictions on other active ingredients in the product, and they can be added as needed. This application also has no special restrictions on the excipients in the product, which can be added according to the product type. This application has no special restrictions on the preparation method of the product, and the preparation method can be adjusted according to the specific substances selected in the product formula.

[0035] The present application uses lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya oleifera stem extract in combination to achieve a synergistic effect, which can significantly promote the increase in the expression of COL1A1, COL3A1 and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect. In addition, the composition provided in the present application can significantly increase the relative expression of FLG and LOR genes in the human immortalized keratinocyte model, and has the effect of repairing the skin barrier. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0037] Figure 1 The test results of the relative expression of FLG gene in Example 1; Figure 2 This is the test result of Example 1 on the relative expression level of LOR gene. DETAILED DESCRIPTION

[0038] The invention discloses the field of cosmetics, and in particular relates to anti-aging and skin barrier repairing compositions, products and applications thereof.

[0039] It should be understood that the expression "one or more of..." includes each of the items recited after the expression individually and in various different combinations of two or more of the recited items, unless otherwise understood from the context and usage. The expression "and / or" in combination with three or more recited items should be understood to have the same meaning, unless otherwise understood from the context.

[0040] The use of the terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, for example not excluding other unrecited elements or steps, unless otherwise specifically stated or otherwise understood from the context.

[0041] It should be understood that the order of steps or the order in which certain actions are performed is not important as long as the present invention remains operable. In addition, two or more steps or actions may be performed simultaneously.

[0042] The use of any and all examples or exemplary language, such as "for example" or "including", herein is intended only to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating that any non-claimed element is essential to the practice of the invention.

[0043] In addition, the numerical ranges and parameters used to define the present invention are approximate values, and the relevant values ​​in the specific embodiments have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. Therefore, unless otherwise expressly stated, it should be understood that all ranges, quantities, values ​​and percentages used in this disclosure are modified by "about". Here, "about" generally means that the actual value is within plus or minus 10%, 5%, 1% or 0.5% of a specific value or range.

[0044] The invention provides an anti-aging and skin barrier repairing composition, comprising lactobionic acid, cryptomeria fortunei bud extract and condiment osmanthus odoratus stem extract.

[0045] The present application uses lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya oleifera stem extract in combination to achieve a synergistic effect, which can significantly promote the increase in the expression of COL1A1, COL3A1 and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect. In addition, the anti-aging and skin barrier repair composition provided by the present application can significantly increase the relative expression of FLG and LOR genes in the human immortalized keratinocyte model, and has the effect of repairing the skin barrier.

[0046] The present invention will be further described below in conjunction with embodiments: In the following embodiments and comparative examples, the Cryptomeria fortunei bud extract and the Murraya osmanthus stem extract were purchased on the market, wherein the Cryptomeria fortunei bud extract was obtained by extraction with water and butylene glycol, and its isopimaric acid content was about 200 ppm; the Murraya osmanthus stem extract was obtained by extraction with water, propylene glycol and betaine, and its flavonoid content was about 35 ppm.

[0047] Examples 1 to 7, Comparative Examples 1-1 to 7-2 According to the formula shown in Table 1, corresponding weights of lactobionic acid, Cryptomeria fortunei bud extract and seasoning Murraya oleifera stem extract were mixed to obtain a composition.

[0048] Table 1 Composition formula provided in Examples and Comparative Examples

[0049] Test Example 1 Human dermal fibroblast model, through the increase rate of COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation, to evaluate whether the sample has anti-wrinkle effect.

[0050] (1) Experimental system: Cell line: human dermal fibroblasts; Cell generation number: at least 2 generations; The number of cells per group: 3×10 5 Pieces / hole.

[0051] (2) Experimental steps: 1. Inoculate cells in 6-well plates (3×10 5 / well), at 37°C, 5% CO 2 Incubate for 24 hours; 2. After the incubation, remove the culture medium, wash with D-Hanks for 1-2 times, and then expose the sample group and the model control group to UVA light at 5J / cm 2 ; 3. After the modeling was completed, the normal control group and the model control group were replaced with fresh culture medium, and the sample group was added with fresh culture medium containing the above samples. The final concentrations of each sample were shown in Table 2. The culture medium was continued at 37°C and 5% CO. 2 Incubate for 24 hours; Table 2 Final concentration of each sample

[0052] 4. Extract total RNA from each experimental group, synthesize cDNA, and use q-PCR to detect the gene expression of β-actin and target genes; 5. Using β-actin as the internal reference for gene expression, calculate the relative RNA expression of the target gene according to the following formula: Relative RNA expression = 2 ΔΔC(t) ; ; ΔC(t)=C(t) 目的基因 -C(t) β-actin ; ; Where Q is the relative gene expression.

[0053] The results are shown in Table 3, which shows the test results of the examples and comparative examples of the present application on the expression enhancement rates of COL1A1, COL3A1 and ELN genes in human dermal fibroblasts after UVA radiation.

[0054] Table 3 Test results of gene expression enhancement rate

[0055] In Table 3 , the up-regulation rate of the relative expression of each gene is the value not * 100%; In Table 3, the synergy coefficient is calculated according to the King's method, and the calculation formula is as follows: q=E A+B / (E A +E B -E A *E B ) Among them, q is the synergy coefficient, E A+B is the up-regulation rate of the corresponding gene in Example X, E A is the up-regulation rate of the corresponding gene in comparative example X-1, E B It is the up-regulation rate of the corresponding gene in comparative example X-2.

[0056] As shown in Table 3, lactobionic acid, Cryptomeria fortunei bud extract and seasoning Murraya oleifera stem extract all have a synergistic effect in the ratio range of 0.3~6:0.5~20:0.4~30, and can significantly promote the increase of COL1A1, COL3A1 and ELN gene expressions in human dermal fibroblasts after UVA radiation.

[0057] UV radiation accelerates skin aging through a series of complex reactions. COL1A1 is the gene responsible for producing type I collagen, COL3A1 is the gene responsible for producing type III collagen, and ELN is the gene responsible for elastin. Therefore, the combination of lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya paniculata stem extract can significantly promote the increase in the expression of COL1A1, COL3A1 and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect.

[0058] Test Example 2 According to the method disclosed in the "Cosmetic Barrier Repair Efficacy Test - In Vitro Human Immortalized Keratinocyte Barrier Repair Factor Determination Standard Operating Procedure", human immortalized keratinocytes were used as a model, and the samples prepared in Example 1 were applied to the cells to detect the relative expression levels of FLG and LOR genes to evaluate whether the samples had repair effects.

[0059] (1) Experimental system: Cell line: immortalized human keratinocytes; Cell generation number: at least 2 generations; The number of cells per group: 6×10 5 Pieces / hole; (2) Experimental steps: 1. Inoculate cells in 6-well plates (6×10 5 / well), at 37°C, 5% CO 2 Incubate for 24 h; 2. After the incubation, the cells were gently rinsed once or twice with D-Hanks, and fresh culture medium was added to the normal control group, and fresh culture medium containing the sample of Example 1 was added to the sample group. The total final concentration of lactobionic acid, Cryptomeria japonica bud extract and Murraya oleifera stem extract in the sample of Example 1 was 0.3125%. The cells were continued to be incubated at 37°C and 5% CO. 2 Incubate for 24 h; 3. After the culture, the cells were sampled, the total RNA of each experimental group was extracted, cDNA was synthesized, and the gene expression of β-actin and the target gene was detected by q-PCR; 4. Using β-actin as the internal reference for gene expression, calculate the relative RNA expression of the target gene according to the following formula: Relative RNA expression = 2 ΔΔC(t) ; ; ΔC(t)=C(t) 目的基因 -C(t) β-actin .

[0060] The results are shown in Table 4. Figure 1 and Figure 2 Table 4 shows the test results of the relative expression of FLG and LOR genes in Example 1. Figure 1 The test results of the relative expression of FLG gene in Example 1 are as follows: Figure 2 This is the test result of Example 1 on the relative expression level of LOR gene.

[0061] Table 4 Test results of relative expression of FLG and LOR genes in Example 1

[0062] In Table 4, * indicates that the p value is less than 0.05 when compared with the normal control group, and ** indicates that the p value is less than 0.01 when compared with the normal control group.

[0063] In the process of repairing skin barrier damage, the regulation of FLG gene expression is a key point. Studies have shown that by upregulating the expression of FLG gene, the skin barrier function can be enhanced, thereby repairing damaged skin. Loricrin (LOR) is the main component of keratinocytes, accounting for about 80% of the total amount of keratinocytes. It is mainly present in the epidermal granular layer. Its main function is to strengthen the keratinocytes, enhance the permeability barrier and interact with the intermediate filaments, increase the flexibility of the keratinocyte structure, and play an important role in the barrier function of the epidermis.

[0064] As can be seen from Table 4, the composition provided in the present application can significantly increase the relative expression levels of FLG and LOR genes, thereby having the effect of repairing the skin barrier.

[0065] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-aging and skin barrier repairing composition, characterized in that: include: Lactobionic acid, Cryptomeria japonica bud extract and spices Murraya oleifera stem extract.

2. The anti-aging and skin barrier repairing composition according to claim 1, characterized in that: The invention comprises, by weight, 0.3 to 8 parts of lactobionic acid, 0.5 to 25 parts of Cryptomeria japonica bud extract and 0.4 to 35 parts of Murraya osmanthus stem extract.

3. The anti-aging and skin barrier repairing composition according to claim 2, characterized in that: The invention comprises, by weight, 0.3-6 parts of lactobionic acid, 0.5-20 parts of Cryptomeria japonica bud extract and 0.4-30 parts of Murraya osmanthus stem extract.

4. The anti-aging and skin barrier repairing composition according to claim 3, characterized in that: The composition comprises, by weight: 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract and 6 parts of Murraya odorifera stem extract; Or it may include: 4 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya paniculata stem extract; Or comprising: 0.3 parts of lactobionic acid, 0.5 parts of Cryptomeria japonica bud extract and 0.4 parts of Murraya paniculata stem extract; Or comprising: 1 part of lactobionic acid, 12 parts of Cryptomeria japonica bud extract and 15 parts of Murraya paniculata stem extract; Or comprising: 6 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya paniculata stem extract; Or it may include: 2 parts of lactobionic acid, 1.5 parts of Cryptomeria japonica bud extract and 1 part of seasoning Murraya osmanthus stem extract.

5. The anti-aging and skin barrier repairing composition according to any one of claims 1 to 4, characterized in that: The Cryptomeria fortunei bud extract is obtained by extraction with water and butylene glycol; The content of isopimaric acid in the Cryptomeria fortunei bud extract is >150ppm; The seasoning Murraya paniculata stem extract is obtained by extracting water, propylene glycol and betaine; The content of flavonoids in the seasoning Murraya paniculata stem extract is greater than 30 ppm.

6. Use of the anti-aging and skin barrier repairing composition according to any one of claims 1 to 5 in the preparation of anti-aging products.

7. Use of the anti-aging and skin barrier repairing composition according to any one of claims 1 to 5 in the preparation of repair products.

8. A product, characterized in that include: The anti-aging and skin barrier repairing composition according to any one of claims 1 to 5.

9. The product according to claim 8, characterized in that include: One or more of personal care products and pharmaceutical products.

10. The product according to claim 9, characterized in that The personal care products include: basic care products and / or makeup products.

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