Nicotine liquid preparation as well as preparation method and application thereof

Abstract

The invention relates to the technical field of electronic atomization, in particular to a nicotine liquid preparation and a preparation method and application thereof. The nicotine liquid preparation provided by the invention is prepared from the following raw material components: nicotine, a nicotine head feeling simulation additive, an atomizing solvent and organic acid, the nicotine head feeling simulation additive is selected from at least one of cytisine, magnolol and 6-methyl nicotine; the content of nicotine in the nicotine liquid preparation is 10-20 mg / g. According to the nicotine liquid preparation formed by compounding the head feeling simulation additive and the nicotine on the specific nicotine, under the synergistic effect of all the components, the satisfaction of a user on the low-nicotine-content liquid preparation is improved, and under the condition of the same experience feeling, the toxicity and addiction are reduced, and health damage is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of electronic atomization, and particularly relates to a nicotine liquid preparation, a preparation method thereof, and an application thereof. Background Art

[0002] An electronic atomization system is a tobacco substitution product that delivers nicotine without tobacco smoke, delivering nicotine into the blood. Like nicotine replacement therapy, it can effectively reduce tobacco intake and help smokers quit smoking. The electronic atomization system mainly consists of three parts: a cartridge, an atomizer, and a power source. The cartridge is a container device for holding the nicotine liquid preparation. The main components of the nicotine liquid preparation are nicotine, propylene glycol, glycerol, flavoring agents, etc. The atomizer is powered by a battery rod and can atomize the liquid nicotine in the cartridge into an aerosol with a specific smell for the user to use.

[0003] The core component in the nicotine liquid preparation is nicotine. When the power source heats the atomizer, the nicotine in the nicotine liquid preparation will be atomized into an aerosol and then inhaled by the human body, thus bringing an improvement in satisfaction. However, nicotine has high toxicity and addiction, and long-term inhalation will affect human health. In order to prevent the abuse of nicotine and ensure the health and safety of the public, currently, various countries have strict supervision over nicotine, restricting the nicotine content to basically 20 mg / g or less. However, the decrease in nicotine content will lead to a decrease in satisfaction. In order to improve the satisfaction of consumers, the prior art generally uses low-content nicotine in the form of nicotine salts. The organic acid commonly used to form nicotine salts is benzoic acid. By compounding benzoic acid with low-content nicotine, the satisfaction is improved, but the improvement effect is still limited. Summary of the Invention

[0004] The purpose of the present invention is to overcome the defects that nicotine in the prior art has high toxicity and addiction, and long-term inhalation will affect human health, and the improvement effect of compounding low-content nicotine with benzoic acid on the satisfaction of users is limited, and further provide a nicotine liquid preparation, a preparation method thereof, and an application thereof.

[0005] To achieve the above purpose, the present invention adopts the following technical solutions:

[0006] The present invention provides a nicotine liquid preparation, and the raw material components of the nicotine liquid preparation include nicotine, a nicotine head feeling simulation additive, an atomization solvent, and an organic acid;

[0007] The nicotine head feeling simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine;

[0008] The nicotine content in the nicotine liquid preparation is 10 - 20 mg / g.

[0009] Preferably, the mass ratio of the nicotine head rush simulation additive to nicotine is (0.1 - 3.7):(1 - 2);

[0010] Preferably, the mass ratio of the nicotine head rush simulation additive to nicotine is (1 - 3.7):(1 - 2).

[0011] Preferably, the nicotine head rush simulation additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine.

[0012] Preferably, the nicotine head rush simulation additive is cytisine and magnolol;

[0013] The mass ratio of cytisine to magnolol is (1 - 20):(1 - 10);

[0014] Optionally, the mass of cytisine accounts for 0.1 - 2% of the mass of the nicotine liquid preparation;

[0015] The mass of magnolol accounts for 0.1 - 1% of the mass of the nicotine liquid preparation.

[0016] Preferably, the nicotine head rush simulation additive is cytisine, magnolol, and 6-methylnicotine;

[0017] The mass ratio of cytisine, magnolol, and 6-methylnicotine is (1 - 20):(1 - 10):(1 - 10);

[0018] Optionally, the mass of cytisine accounts for 0.1 - 2% of the mass of the nicotine liquid preparation;

[0019] The mass of magnolol accounts for 0.1 - 1% of the mass of the nicotine liquid preparation;

[0020] The mass of 6-methylnicotine accounts for 0.1 - 1% of the mass of the nicotine liquid preparation.

[0021] Preferably, the mass ratio of the atomization solvent to nicotine is (40 - 97.8):(1 - 2).

[0022] Preferably, the atomization solvent includes at least one of propylene glycol, glycerol, water, ethanol, triacetin, and sorbitol.

[0023] Preferably, the atomization solvent is propylene glycol and glycerol;

[0024] The mass ratio of propylene glycol to glycerol is (1 - 50):(1 - 50).

[0025] Preferably, the organic acid includes at least one of C3 - C8 organic carboxylic acids;

[0026] Optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acids, C3-C8 dibasic organic carboxylic acids, and C3-C8 tribasic organic carboxylic acids.

[0027] Preferably, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid;

[0028] Optionally, the organic acid is benzoic acid.

[0029] Preferably, based on the carboxyl group of the organic acid, the molar ratio of the organic acid to nicotine is (1-2):(1-2);

[0030] Preferably, based on the carboxyl group of the organic acid, the molar ratio of the organic acid to nicotine is 1:1.

[0031] Preferably, based on the carboxyl group of the organic acid, the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is (0.98-2):(0.98-2);

[0032] Preferably, based on the carboxyl group of the organic acid, the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is 1:1.

[0033] Optionally, based on the carboxyl group of the organic acid, the molar ratio of the organic acid to 6-methylnicotine is (1-2):(1-2).

[0034] Optionally, in the nicotine liquid preparation, nicotine and the organic acid may exist in the form of nicotine organic salts, and 6-methylnicotine and the organic acid may exist in the form of 6-methylnicotine organic salts.

[0035] Preferably, the raw material components of the nicotine liquid preparation further include flavor.

[0036] Preferably, the flavor includes at least one of tobacco flavor, fruit flavor, and mint flavor;

[0037] Optionally, the fruit flavor includes at least one of blueberry flavor, strawberry flavor, and watermelon flavor.

[0038] Preferably, the mass ratio of the flavor to nicotine is (20-50):(1-2).

[0039] The nicotine liquid preparation of the present invention is used to enhance the sense of satisfaction, and further, to enhance the smoking experience of consumers.

[0040] The present invention provides a preparation method of the above-mentioned nicotine liquid preparation, which includes the following steps:

[0041] The nicotine, nicotine head-feeling simulating additive, atomizing solvent and organic acid are mixed, and then heated and stirred to obtain the product.

[0042] Preferably, the method for preparing the nicotine liquid preparation further comprises the step of adding flavors.

[0043] The present invention does not specifically limit the stirring method. Optionally, the stirring method is selected from mechanical stirring, mechanical oscillation or ultrasonic oscillation.

[0044] The present invention provides use of the above-mentioned nicotine liquid preparation or the nicotine liquid preparation prepared by the above-mentioned preparation method in an atomization device.

[0045] Preferably, the atomization device is an electronic atomization device.

[0046] Beneficial effects of the present invention:

[0047] The nicotine liquid preparation provided by the present invention comprises nicotine, a nicotine head feeling simulation additive, an atomizing solvent and an organic acid as raw material components of the nicotine liquid preparation; the nicotine head feeling simulation additive is selected from at least one of cytisine, magnolol and 6-methyl nicotine; the nicotine content in the nicotine liquid preparation is 10-20mg / g. The present invention adopts a nicotine head feeling simulation additive (at least one of cytisine, magnolol and 6-methyl nicotine) to make the brain produce a head feeling similar to that of nicotine, which can partially replace the activation effect of nicotine, and adopts a low content (10-20mg / g) of nicotine to provide a throat hit; the nicotine liquid preparation formed by the compounding of a specific nicotine head feeling simulation additive and nicotine is conducive to improving the user's satisfaction with the low nicotine content liquid preparation under the synergistic effect of each component, and reduces toxicity and addiction under the same suction experience, and reduces health damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0049] Figure 1 Normalized heart rate graphs of Example 2, Example 6, Example 12, Example 13 and Comparative Example 1 of the present invention;

[0050] Figure 2 Average normalized heart rate graphs of Example 2, Example 6, Example 12, Example 13 and Comparative Example 1 of the present invention. Detailed implementation mode

[0051] The following embodiments are provided to better understand the present invention further. They are not limited to the best implementation mode, and do not constitute a limitation on the content and protection scope of the present invention. Any product identical or similar to the present invention obtained by anyone under the inspiration of the present invention or by combining the features of the present invention with those of other prior arts falls within the protection scope of the present invention.

[0052] For those not specifying specific experimental steps or conditions in the embodiments, the operations or conditions of the conventional experimental steps described in the literature in this field can be followed. For the reagents or instruments not specifying the manufacturer, they are all conventional reagent products that can be obtained through commercial purchase.

[0053] The core component in the nicotine liquid preparation is nicotine. When the power source heats the atomizer, the nicotine in the nicotine liquid preparation will be atomized into aerosol and then inhaled by the human body. Part of the aerosol is transmitted to the larynx, and there are also acetylcholine receptors distributed in the larynx. The nicotine deposited in the larynx can bind to the acetylcholine receptors, causing a throat hit feeling. Another part of the aerosol will enter the lungs to participate in the pulmonary vein circulation, and then enter the arterial circulation, quickly transmitting the nicotine to the brain and combining with the acetylcholine receptors in the brain, promoting the brain to release neurotransmitters (dopamine). The release of dopamine is a pleasant experience, which will enhance the reward function of the brain, produce a high feeling, and make smokers feel satisfied. Satisfaction is a comprehensive evaluation of the high feeling and the throat hit feeling. An appropriate throat hit feeling helps to improve the overall satisfaction. However, if the throat hit feeling is too strong, it will cause too high a suction irritation and physical discomfort, thus reducing the satisfaction. Nicotine has great toxicity and addiction, and long-term inhalation will affect human health. In order to prevent the abuse of nicotine and ensure the health and safety of the public, currently, various countries have strict supervision on the nicotine in e-cigarette products, basically limiting the nicotine content to 20 mg / g and below. However, the decrease in nicotine content will lead to a decrease in satisfaction. In order to improve the satisfaction of consumers, the prior art generally uses nicotine in the form of nicotine salts. The commonly used organic acid for forming nicotine salts is benzoic acid. By compounding nicotine with benzoic acid, the satisfaction can be improved, but the improvement effect is still limited.

[0054] Cytisine is an extract of leguminous plants and has been proven to have a high affinity for the α4β2 subtype of the nicotinic acetylcholine receptor and is a low non-specific partial agonist. The inventor found that cytisine can interact with the acetylcholine receptors in the brain to produce a nicotine-like activation effect, which is synergistic with nicotine and is beneficial to improving satisfaction.

[0055] Magnolol is an active ingredient in the extract of Magnolia officinalis plants and has effects such as sedation, anti - anxiety, and anti - epilepsy. Magnolol can increase the ratio of 5 - hydroxyindoleacetic acid / 5 - hydroxytryptamine (5 - HIAA / 5 - HT) in the frontal cortex, striatum, and nucleus accumbens, inhibit the increase in serum corticosterone levels, and reverse the decrease in platelet adenylate cyclase activity induced by chronic mild stress (CMS), thus playing an antidepressant role. Magnolol can counteract the inhibition of endogenous enkephalin release by exogenous morphine and produce an effect of relieving withdrawal symptoms. Magnolol can also antagonize the excitatory effects of the central excitatory neurotransmitters glutamate and N - methyl - D - aspartic acid (NMDA) by promoting the release of β - endorphin and activating cannabinoid receptors. Magnolol mainly counteracts the damage of excitatory neurotransmitters to nerve cells by promoting the biosynthesis of γ - aminobutyric acid (GABA), increasing the content of GABA, and enhancing the binding of GABA to receptors.

[0056] 6 - Methylnicotine (CAS: 13270 - 56 - 9) is an organic intermediate and belongs to nicotine analogs. It is reported that the affinity of nicotine analogs for nicotinic acetylcholine receptors (nAChR) is related to the lipophilicity of their 6 - position substituents. Further relevant studies have shown that as the size of the substituents increases, the affinity decreases. The affinity of nicotine analogs is determined by the lipophilicity of the 6 - position substituents and is also related to the size of the substituents. Among them, the 6 - position substituent of 6 - methylnicotine has the smallest volume and strong lipophilicity, and also has a strong affinity for the nAChR receptor, showing good medicinal prospects.

[0057] The inventors unexpectedly found that when nicotine is compounded with a nicotine head - feeling simulation additive (at least one of sparteine, magnolol, and 6 - methylnicotine), nicotine and the nicotine head - feeling simulation additive have a synergistic effect, which is beneficial to improving the satisfaction of users when the nicotine content is not higher than 20 mg / g.

[0058] The present invention provides a nicotine liquid preparation, and the raw material components of the nicotine liquid preparation include nicotine, a nicotine head rush simulation additive, an atomization solvent, and an organic acid; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine; the nicotine content in the nicotine liquid preparation is 10-20 mg / g. The present invention uses a nicotine head rush simulation additive (at least one of cytisine, magnolol, and 6-methylnicotine) to produce an effect similar to the head rush of nicotine in the brain, which can partially replace the activation effect of nicotine, and uses nicotine with a low content (10-20 mg / g) to provide a throat hit feeling; the nicotine liquid preparation formed by the compounding of a specific nicotine head rush simulation additive and nicotine is beneficial to improving the satisfaction of users with a low-nicotine-content liquid preparation under the synergistic action of each component, reducing toxicity and addiction, and reducing health damage under the condition of the same experience. Optionally, in some alternative embodiments, the nicotine content in the nicotine liquid preparation is 10 mg / g, 11 mg / g, 12 mg / g, 13 mg / g, 14 mg / g, 15 mg / g, 16 mg / g, 17 mg / g, 18 mg / g, 19 mg / g, 20 mg / g.

[0059] In some alternative embodiments, the mass ratio of the nicotine head rush simulation additive to nicotine is (0.1 - 3.7):(1 - 2); for example, optionally, the mass ratio of the nicotine head rush simulation additive to nicotine can be 0.1:1, 0.2:1, 0.3:1, 0.5:1, 0.7:1, 0.9:1, 1:1, 1.3:1, 1.4:1, 1.5:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 2.1:1, 2.3:1, 2.5:1, 2.8:1, 3:1, 3.1:1, 3.3:1, 3.4:1, 3.5:1, 3.7:1, 0.1:1.25, 0.2:1.25, 0.3:1.25, 0.5:1.25, 0.7:1.25, 0.9:1.25, 1:1.25, 1.3:1.25, 1.4:1.25, 1.5:1.25, 1.7:1.25, 1.8:1.25, 1.9:1.25, 2:1.25, 2.1:1.25, 2.3:1.25, 2.5:1.25, 2.8:1.25, 3:1.25, 3.1:1.25, 3.3:1.25, 3.4:1.25, 3.5:1.25, 3.7:1.25, 0.1:1.5, 0.2:1.5, 0.3:1.5, 0.5:1.5, 0.7:1.5, 0.9:1.5, 1:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 2.1:1.5, 2.3:1.5, 2.5:1.5, 2.8:1.5, 3:1.5, 3.1:1.5, 3.3:1.5, 3.4:1.5, 3.5:1.5, 3.7:1.5, 0.1:1.75, 0.2:1.75, 0.3:1.75, 0.5:1.75, 0.7:1.75, 0.9:1.75, 1:1.75, 1.3:1.75, 1.4:1.75, 1.5:1.75, 1.7:1.75, 1.8:1.75, 1.9:1.75, 2:1.75, 2.1:1.75, 2.3:1.75, 2.5:1.75, 2.8:1.75, 3:1.75, 3.1:1.75, 3.3:1.75, 3.4:1.75, 3.5:1.75, 3.7:1.75, 0.1:2, 0.2:2, 0.3:2, 0.5:2, 0.7:2, 0.9:2, 1:2, 1.3:2, 1.4:2, 1.5:2, 1.7:2, 1.8:2, 1.9:2, 2:2, 2.1:2, 2.3:2, 2.5:2, 2.8:2, 3:2, 3.1:2, 3.3:2, 3.4:2, 3.5:2, 3.7:2.Preferably, the mass ratio of the nicotine head rush simulation additive to nicotine is (1 - 3.7):(1 - 2). The inventors found that by controlling the mass ratio of the nicotine head rush simulation additive to nicotine within the range of (1 - 3.7):(1 - 2), the satisfaction of users is further improved under their synergistic effect.

[0060] In some alternative embodiments, the nicotine head rush simulation additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine. The inventors found that when the nicotine head rush simulation additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine, the improvement in the satisfaction of users is more obvious than when only one kind of nicotine head rush simulation additive is selected, and it can even reach or be better than the satisfaction of the nicotine liquid preparation on the market with benzoic acid as the organic acid and a nicotine content of 30 mg / g.

[0061] In some alternative embodiments, the nicotine head rush simulation additive is cytisine and magnolol; the mass ratio of cytisine to magnolol is (1 - 20):(1 - 10); for example, optionally, the mass ratio of cytisine to magnolol can be 1:1, 3:1, 4:1, 5:1, 7:1, 8:1, 9:1, 10:1, 11:1, 13:1, 15:1, 17:1, 19:1, 20:1, 1:3, 3:3, 4:3, 5:3, 7:3, 8:3, 9:3, 10:3, 11:3, 13:3, 15:3, 17:3, 19:3, 20:3, 1:5, 3:5, 4:5, 5:5, 7:5, 8:5, 9:5, 10:5, 11:5, 13:5, 15:5, 17:5, 19:5, 20:5, 1:7, 3:7, 4:7, 5:7, 7:7, 8:7, 9:7, 10:7, 11:7, 13:7, 15:7, 17:7, 19:7, 20:7, 1:10, 3:10, 4:10, 5:10, 7:10, 8:10, 9:10, 10:10, 11:10, 13:10, 15:10, 17:10, 19:10, 20:10. Optionally, the mass of cytisine accounts for 0.1 - 2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1 - 1% of the mass of the nicotine liquid preparation. For example, optionally, the mass of cytisine accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% of the mass of the nicotine liquid preparation.

[0062] In some alternative embodiments, the nicotine head rush simulation additive is sparteine, magnolol, and 6-methylnicotine; the inventors have found that when the nicotine head rush simulation additive is selected from the combination of sparteine, magnolol, and 6-methylnicotine, the satisfaction of the user is most significantly improved, and the satisfaction can even reach that of a nicotine liquid preparation on the market with benzoic acid as the organic acid and a nicotine content of 50 mg / g. Under the condition of the same experience, it can effectively reduce toxicity and addiction and reduce health damage. The mass ratio of sparteine, magnolol, and 6-methylnicotine is (1-20):(1-10):(1-10); for example, the mass ratio of sparteine and magnolol can be 1:1:1, 3:1:2, 4:1:1, 5:1:5, 7:1:9, 8:1:10, 9:1:1, 10:1:9, 11:1:1, 13:1:6, 15:1:6, 17:1:2, 19:1:1, 20:1:9, 1:3, 3:3:1, 4:3:1, 5:3:4, 7:3:6, 8:3:1, 9:3:8, 10:3:10, 11:3:10, 13:3:3, 15:3:1, 17:3:9, 19:3:2, 20:3:10, 1:5:1, 3:5:10, 4:5:2, 5:5:5, 7:5:6, 8:5:9, 9:5:10, 10:5:1, 11:5:6, 13:5:9, 15:5:10, 17:5:8, 19:5:8, 20:5:9, 1:7:8, 3:7:9, 4:7:10, 5:7:10, 7:7:1, 8:7:1, 9:7:2, 10:7:10, 11:7:9, 13:7:10, 15:7:1, 17:7:1, 19:7:10, 20:7:5, 1:10:1, 3:10:2, 4:10:10, 5:10:10, 7:10:1, 8:10:5, 9:10:9, 10:10:5, 11:10:4, 13:10:3, 15:10:7, 17:10:10, 19:10:8, 20:10:8. Optionally, the mass of sparteine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation; the mass of 6-methylnicotine accounts for 0.1-1% of the mass of the nicotine liquid preparation.For example, optionally, the mass of anabasine accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% of the mass of the nicotine liquid preparation; the mass of 6-methylnicotine accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% of the mass of the nicotine liquid preparation.

[0063] In some alternative embodiments, the atomization solvent can be a conventional atomization solvent in the art, including but not limited to at least one of propylene glycol, glycerol, water, ethanol, triacetin, sorbitol; optionally, the mass ratio of the atomization solvent to nicotine is (40 - 97.8):(1 - 2). For example, the optionally selected mass ratios of the atomization solvent to nicotine are 40:1, 45:1, 47:1, 50:1, 60:1, 70:1, 80:1, 90:1, 97.8:1, 40:1.5, 45:1.5, 47:1.5, 50:1.5, 60:1.5, 70:1.5, 80:1.5, 90:1.5, 97.8:1.5, 40:2, 45:2, 47:2, 50:2, 60:2, 70:2, 80:2, 90:2, 97.8:2. Preferably, the atomization solvent is propylene glycol and glycerol. The mass ratio of propylene glycol to glycerol is (1 - 50):(1 - 50). For example, the optionally selected mass ratios of propylene glycol to glycerol are 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:13, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 2:1, 2:3, 2:5, 2:7, 2:9, 2:10, 2:13, 2:15, 2:20, 2:25, 2:30, 2:35, 2:40, 2:45, 2:50, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 12:1, 13:1, 15:1, 18:1, 20:1, 22:1, 25:1, 29:1, 30:1, 32:1, 35:1, 40:1, 43:1, 45:1, 47:1, 50:1. The addition of the atomization solvent in the present invention can better dissolve the raw material components, effectively improve the atomization efficiency of nicotine, and increase the sense of satisfaction.

[0064] In some alternative embodiments, the atomizing solvent is propylene glycol, glycerol, and ethanol. For example, optionally, the mass ratio of propylene glycol, glycerol, and ethanol is (1 - 50):(1 - 50):(1 - 2).

[0065] In some alternative embodiments, the organic acid includes at least one of C3 - C8 organic carboxylic acids; further optionally, the organic acid includes at least one of C3 - C8 monobasic organic carboxylic acids, C3 - C8 dibasic organic carboxylic acids, and C3 - C8 tribasic organic carboxylic acids. Further optionally, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; still further optionally, the organic acid is benzoic acid. By further adding a specific organic acid to the raw material components to form a nicotine salt in the present invention, the satisfaction of users can be further ensured.

[0066] In some alternative embodiments, based on the carboxyl group of the organic acid, the molar ratio of the organic acid to nicotine is (1 - 2):(1 - 2); for example, optionally, based on the carboxyl group of the organic acid, the molar ratio of the organic acid to nicotine is 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, 2:1.2, 1:1.5, 1.1:1.5, 1.2:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.6:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 1:1.7, 1.1:1.7, 1.2:1.7, 1.3:1.7, 1.4:1.7, 1.5:1.7, 1.6:1.7, 1.7:1.7, 1.8:1.7, 1.9:1.7, 2:1.7, 1:2, 1.1:2, 1.2:2, 1.3:2, 1.4:2, 1.5:2, 1.6:2, 1.7:2, 1.8:2, 1.9:2, 2:2. After adding the head - feeling simulation additive nicotine in the synergistic substance, the inventor further found that the addition amount of the organic acid will affect the satisfaction. Benzoic acid and nicotine will combine to form a salt state. Changing the molar ratio of the organic acid to nicotine can change the acid - base environment of the throat and affect the strength of the throat - hitting feeling during the process of the aerosol entering the lungs. The inventor found that based on the carboxyl group of the organic acid, when the molar ratio of the organic acid to nicotine is (1 - 2):(1 - 2), both the head - feeling and the throat - hitting feeling during suction will change, and the comprehensive satisfaction is high.

[0067] In some alternative embodiments, in terms of carboxyl groups, the molar ratio of the organic acid to 6-methyl nicotine is (1 - 2):(1 - 2); for example, optionally, in terms of carboxyl groups, the molar ratio of the organic acid to 6-methyl nicotine can be 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, 2:1.2, 1:1.5, 1.1:1.5, 1.2:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.6:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 1:1.7, 1.1:1.7, 1.2:1.7, 1.3:1.7, 1.4:1.7, 1.5:1.7, 1.6:1.7, 1.7:1.7, 1.8:1.7, 1.9:1.7, 2:1.7, 1:2, 1.1:2, 1.2:2, 1.3:2, 1.4:2, 1.5:2, 1.6:2, 1.7:2, 1.8:2, 1.9:2, 2:2.

[0068] In some alternative embodiments, based on the carboxyl group of the organic acid, the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is (0.98 - 2):(0.98 - 2). For example, optionally, based on the carboxyl group of the organic acid, the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is 0.98:0.99, 0.99:0.98, 0.98:1, 0.99:1, 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 0.98:1.2, 0.99:1.2, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, 2:1.2, 0.98:1.5, 0.99:1.5, 1:1.5, 1.1:1.5, 1.2:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.6:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 0.98:1.7, 0.99:1.7, 1:1.7, 1.1:1.7, 1.2:1.7, 1.3:1.7, 1.4:1.7, 1.5:1.7, 1.6:1.7, 1.7:1.7, 0.98:1.8, 0.99:1.8, 1.8:1.7, 1.9:1.7, 2:1.7, 0.98:2, 0.99:2, 1:2, 1.1:2, 1.2:2, 1.3:2, 1.4:2, 1.5:2, 1.6:2, 1.7:2, 1.8:2, 1.9:2, 2:2. After adding the synergistic substance nicotine head feeling simulation additive, the inventors further found that the addition amount of the organic acid will affect the satisfaction. Both nicotine and 6-methylnicotine will combine with benzoic acid to form salts, and changing the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid can change the acid-base environment of the throat and affect the strength of the throat hit feeling during the process of aerosol entering the lungs. The inventors found that when, based on the carboxyl group of the organic acid, the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is (0.98 - 2):(0.98 - 2), both the head feeling and the throat hit feeling during suction will change, and the comprehensive satisfaction is high.

[0069] In some alternative embodiments, the raw material components of the nicotine liquid preparation further include flavoring agents. The flavoring agents can be conventional existing flavoring materials in the art, which can be obtained commercially or prepared by conventional preparation methods. For example, they can be monomeric flavor raw materials or a mixture of various extracts, including but not limited to tobacco flavor, fruit flavor, and mint flavor. Further, the fruit flavor includes at least one of blueberry flavor, strawberry flavor, and watermelon flavor. Optionally, the mass ratio of the flavoring agent to nicotine is (20 - 50):(1 - 2). For example, the mass ratio of the flavoring agent to nicotine can be 20:1, 22:1, 25:1, 27:1, 30:1, 32:1, 35:1, 37:1, 39:1, 40:1, 42:1, 45:1, 47:1, 49:1, 50:1, 20:1.2, 22:1.2, 25:1.2, 27:1.2, 30:1.2, 32:1.2, 35:1.2, 37:1.2, 39:1.2, 40:1.2, 42:1.2, 45:1.2, 47:1.2, 49:1.2, 50:1.2, 20:1.5, 22:1.5, 25:1.5, 27:1.5, 30:1.5, 32:1.5, 35:1.5, 37:1.5, 39:1.5, 40:1.5, 42:1.5, 45:1.5, 47:1.5, 49:1.5, 50:1.5, 20:1.7, 22:1.7, 25:1.7, 27:1.7, 30:1.7, 32:1.7, 35:1.7, 37:1.7, 39:1.7, 40:1.7, 42:1.7, 45:1.7, 47:1.7, 49:1.7, 50:1.7, 20:2, 22:2, 25:2, 27:2, 30:2, 32:2, 35:2, 37:2, 39:2, 40:2, 42:2, 45:2, 47:2, 49:2, 50:2.

[0070] The present invention also provides a preparation method of the above-mentioned nicotine liquid preparation, which includes the following steps: mixing nicotine, a nicotine head-feeling simulation additive, an atomization solvent, and an organic acid, and then heating and stirring evenly to obtain the product.

[0071] In some alternative embodiments, the preparation method of the nicotine liquid preparation further includes a step of adding a flavoring agent.

[0072] The present invention does not specifically limit the heating and stirring temperature and time, as long as the raw materials can be dissolved. Optionally, the dissolution temperature is not higher than 100°C. Optionally, the heating and stirring temperature is 40 - 65°C, and the heating and stirring time is 20 - 30 min. In the present invention, all the raw materials can be mixed and then heated for dissolution, or some of the raw materials can be mixed and dissolved first, and then the remaining raw materials can be mixed and dissolved. In some optional embodiments, the method for preparing the nicotine liquid preparation includes the following steps: mixing nicotine, nicotine top note simulation additives, organic acids, and atomization solvents, heating at 40 - 65°C for 20 - 30 minutes to dissolve and mix evenly, and then adding flavors and stirring at 10 - 40°C for 5 - 40 min to mix evenly to obtain the nicotine liquid preparation.

[0073] The present invention also provides an application of the above-mentioned nicotine liquid preparation or the nicotine liquid preparation prepared by the above-mentioned preparation method in an atomization device. Optionally, the atomization device is an electronic atomization device.

[0074] Example 1

[0075] This example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0076] Mix 2 g of nicotine, 1.50 g of benzoic acid, 0.1 g of cytisine, 0.3 g of magnolol, 11.1 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly, cool to room temperature, add 45 g of blueberry flavor, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0077] Example 2

[0078] This example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0079] Mix 2 g of nicotine, 1.50 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 10.5 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly, cool to room temperature, add 45 g of blueberry flavor, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0080] Example 3

[0081] This example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0082] Mix 2 g of nicotine, 1.50 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 9.7 g of propylene glycol and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min until dissolved and mixed evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0083] Example 4

[0084] This example provides a preparation method of a nicotine liquid preparation, including the following steps:

[0085] Mix 2 g of nicotine, 1.50 g of benzoic acid, 2 g of cytisine, 0.3 g of magnolol, 9.2 g of propylene glycol and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min until dissolved and mixed evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0086] Example 5

[0087] This example provides a preparation method of a nicotine liquid preparation, including the following steps:

[0088] Mix 2 g of nicotine, 1.50 g of benzoic acid, 2.0 g of cytisine, 1 g of magnolol, 8.5 g of propylene glycol and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min until dissolved and mixed evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0089] Example 6

[0090] This example provides a preparation method of a nicotine liquid preparation, including the following steps:

[0091] Mix 2 g of nicotine, 1.50 g of benzoic acid, 0.4 g of cytisine, 0.3 g of magnolol, 0.3 g of 6-methylnicotine, 10.5 g of propylene glycol and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min until dissolved and mixed evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0092] Example 7

[0093] This example provides a preparation method of a nicotine liquid preparation, including the following steps:

[0094] Mix 1.5 g of nicotine, 1.48 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 0.5 g of 6-methylnicotine, 10.52 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly. After cooling to room temperature, add 45 g of blueberry essence and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0095] Example 8

[0096] This example provides a method for preparing a nicotine liquid preparation, which includes the following steps:

[0097] Mix 1.3 g of nicotine, 1.48 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 0.7 g of 6-methylnicotine, 10.52 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly. After cooling to room temperature, add 45 g of blueberry essence and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0098] Example 9

[0099] This example provides a method for preparing a nicotine liquid preparation, which includes the following steps:

[0100] Mix 1.3 g of nicotine, 1.46 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 0.7 g of 6-methylnicotine, 9.74 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly. After cooling to room temperature, add 45 g of blueberry essence and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0101] Example 10

[0102] This example provides a method for preparing a nicotine liquid preparation, which includes the following steps:

[0103] Mix 1.3 g of nicotine, 1.46 g of benzoic acid, 2.0 g of cytisine, 1.0 g of magnolol, 0.7 g of 6-methylnicotine, 8.54 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60°C water bath for 20 min to dissolve and mix evenly. After cooling to room temperature, add 45 g of blueberry essence and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0104] Example 11

[0105] This example provides a method for preparing a nicotine liquid preparation, which includes the following steps:

[0106] Mix 1.0 g of nicotine, 1.45 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 1.0 g of 6-methylnicotine, 9.75 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60 °C water bath for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0107] Example 12

[0108] This example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0109] Mix 2 g of nicotine, 1.50 g of benzoic acid, 1 g of cytisine, 10.5 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60 °C water bath for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0110] Example 13

[0111] This example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0112] Mix 2 g of nicotine, 1.50 g of benzoic acid, 1 g of magnolol, 10.5 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60 °C water bath for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0113] Comparative Example 1

[0114] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0115] Mix 2.0 g of nicotine, 1.50 g of benzoic acid, 11.5 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60 °C water bath for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0116] Comparative Example 2

[0117] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0118] Mix 3.0 g of nicotine, 2.26 g of benzoic acid, 9.74 g of propylene glycol, and 40 g of glycerol, heat and stir in a 60 °C water bath for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0119] Comparative Example 3

[0120] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0121] Mix 4.0 g of nicotine, 3 g of benzoic acid, 8.0 g of propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0122] Comparative Example 4

[0123] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0124] Mix 5.0 g of nicotine, 3.76 g of benzoic acid, 6.24 g of propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to dissolve and mix evenly, add 45 g of blueberry essence after cooling to room temperature, and continue to stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0125] Test Example

[0126] The present invention scores various smoking indexes of the nicotine liquid preparations of Examples 1-13 and Comparative Examples 1-4 by means of subjective smoking. The smoking team has 12 people, all of whom have more than 5 years of experience in traditional cigarettes or more than 3 years of experience in e-cigarette smoking, and nicotine withdrawal is carried out 12 hours before smoking.

[0127] Each smoker has a smoking evaluation form and adopts a blind-draw scoring method. Different examples and comparative examples are randomly coded by three-digit numbers. The evaluator starts smoking at 10 am and smokes the next random sample every hour. The smoking method is as follows: During the process of smoking a sample, the smoker smokes a total of 8 puffs (each puff lasts for 3 s and the interval between each puff is 27 s), the smoke stays in the mouth for a short time, and then the smoke is swallowed into the lungs. The smokers cannot communicate their smoking feelings and score and evaluate according to the evaluation indexes in Table 1 respectively, and write down their smoking results in the smoking evaluation form. The test results are shown in Table 2 (the scoring value is the average score).

[0128] Table 1 Evaluation Indexes

[0129]

[0130] Table 2 Smoking Scoring Data

[0131]

[0132]

[0133] Heart rate tests were conducted on the nicotine liquid preparations (hereinafter referred to as samples) prepared in Example 2, Example 6, Example 12, Example 13 and Comparative Example 1 during puffing. The test method was as follows: The puffing personnel underwent nicotine withdrawal the night before the puffing test, and the heart rate test during puffing was conducted at 9:00 am on the day of puffing. Before puffing, wear the heart rate test instrument well (the heart rate test instrument is Lepu Xin'anbao ER1), and monitor the real-time change of heart rate throughout the puffing process. After the heart rate instrument was worn and adjusted, a 2-minute baseline heart rate test was conducted. After the heart rate became stable, the heart rate monitoring during the puffing process began. Use the RELX 5th generation cigarette rod (matched with samples of different examples and comparative examples), and draw 5 puffs of smoke in total (each puff is drawn for 3 s, and the interval between adjacent puffs is 27 s). The total puffing time is about 2.5 min, and record the start time of each puff of smoke. After puffing, continue to monitor the heart rate change for 1 min, and then end the experiment. After finishing one sample, withdraw for 2 hours, and then conduct the heart rate test during the puffing process of the next sample. The test results are as Figure 1 and 2 shown, where Figure 1 the normalized heart rate is the ratio of the real-time monitored heart rate during puffing to the average baseline heart rate within the above 2 minutes, Figure 2 and the average normalized heart rate is the ratio of the average monitored heart rate during puffing to the average baseline heart rate.

[0134] Obviously, the above examples are only illustrations for clear explanation and not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or variations can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. And the obvious changes or variations derived therefrom are still within the protection scope of the present invention.

Claims

1. A nicotine liquid preparation, characterized in that, the raw material components of the nicotine liquid preparation include nicotine, a nicotine head rush simulation additive, an atomization solvent, and an organic acid; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine; the nicotine content in the nicotine liquid preparation is 10-20 mg / g.

2. The nicotine liquid preparation according to claim 1, characterized in that, the mass ratio of the nicotine head rush simulation additive to nicotine is (0.1-3.7):(1-2); preferably, the mass ratio of the nicotine head rush simulation additive to nicotine is (1-3.7):(1-2).

3. The nicotine liquid preparation according to claim 1 or 2, characterized in that, the nicotine head rush simulation additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine.

4. The nicotine liquid preparation according to any one of claims 1-3, characterized in that, the nicotine head rush simulation additive is cytisine and magnolol; the mass ratio of cytisine to magnolol is (1-20):(1-10); optionally, the mass of cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation.

5. The nicotine liquid preparation according to any one of claims 1-3, characterized in that, the nicotine head rush simulation additive is cytisine, magnolol, and 6-methylnicotine; the mass ratio of cytisine, magnolol, and 6-methylnicotine is (1-20):(1-10):(1-10); optionally, the mass of cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation; the mass of 6-methylnicotine accounts for 0.1-1% of the mass of the nicotine liquid preparation.

6. The nicotine liquid preparation according to any one of claims 1-5, characterized in that, the mass ratio of the atomization solvent to nicotine is (40-97.8):(1-2).

7. The nicotine liquid preparation according to any one of claims 1-6, characterized in that, the atomization solvent includes at least one of propylene glycol, glycerol, water, ethanol, triacetin, and sorbitol.

8. The nicotine liquid preparation according to any one of claims 1-7, characterized in that, the atomization solvent is propylene glycol and glycerol; the mass ratio of propylene glycol to glycerol is (1-50):(1-50).

9. The nicotine liquid preparation according to any one of claims 1-8, characterized in that, the organic acid includes at least one of C3-C8 organic carboxylic acids; optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acids, C3-C8 dibasic organic carboxylic acids, and C3-C8 tribasic organic carboxylic acids.

10. The nicotine liquid preparation according to any one of claims 1-9, characterized in that, The organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; Optionally, the organic acid is benzoic acid.

11. The nicotine liquid preparation according to any one of claims 1-10, characterized in that Calculated by carboxyl group, the molar ratio of the organic acid to nicotine is (1-2):(1-2); Preferably, calculated by carboxyl group, the molar ratio of the organic acid to nicotine is 1:

1.

12. The nicotine liquid preparation according to any one of claims 1-10, characterized in that Calculated by carboxyl group, the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is (0.98-2):(0.98-2); Preferably, calculated by carboxyl group, the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is 1:

1.

13. The nicotine liquid preparation according to any one of claims 1-12, characterized in that The raw material components of the nicotine liquid preparation further include essence.

14. The nicotine liquid preparation according to claim 13, characterized in that The essence includes at least one of tobacco essence, fruit essence, and mint essence; Optionally, the fruit essence includes at least one of blueberry essence, strawberry essence, and watermelon essence.

15. The nicotine liquid preparation according to any one of claims 13-14, characterized in that The mass ratio of the essence to nicotine is (20-50):(1-2).

16. A preparation method of the nicotine liquid preparation according to any one of claims 1-15, characterized in that comprises the following steps: Mix nicotine, nicotine top note simulation additive, atomization solvent and organic acid, and then heat and stir evenly to obtain.

17. The preparation method of the nicotine liquid preparation according to claim 16, characterized in that It further includes the step of adding essence.

18. Application of the nicotine liquid preparation according to any one of claims 1-15 or the nicotine liquid preparation prepared by the preparation method according to any one of claims 16 or 17 in an atomization device.

19. The application according to claim 18, characterized in that The atomization device is an electronic atomization device.

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