Whitening composition and preparation method thereof

Abstract

The invention provides a whitening composition and a preparation method thereof, and belongs to the technical field of cosmetics. The whitening composition comprises vitamin C and derivatives thereof, pearl powder, grease and oil gel combined by hydrogen bonds. The oleogel combined by the hydrogen bonds comprises a cross-linked polymer, the mass ratio of the oleogel combined by the hydrogen bonds to the active ingredients is 1: (1-2), and the active ingredients comprise vitamin C and derivatives thereof and pearl powder. According to the whitening composition, an oleogel suspension technology is adopted, the oleogel combined by hydrogen bonds is selected to build a compact network structure, and the active ingredients and the grease are dispersed in the compact network structure, so that the chemical structural integrity of the active ingredients is maintained to a great extent, and the skin whitening effect is ensured within the storage and use period of the product. Vitamin C and the derivative thereof can stably exist and continuously release effects, reliable and long-acting skin care effects of whitening, oxidation resistance and the like are provided for a user, the stability of the whitening composition is improved, and the application range and the use experience of the product are expanded.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics. Specifically, it relates to a whitening composition and a preparation method thereof. Background Art

[0002] With the increasing demand for skin care among people, skin care products with multiple functions such as whitening and antioxidant effects have attracted much attention. Vitamin C (VC) and its derivatives have excellent antioxidant properties, can effectively inhibit melanin production, brighten skin tone, and promote collagen synthesis at the same time, and have broad application prospects in the skin care field. However, usually VC and its derivatives are stable when dry, but are easily oxidized in aqueous solutions, especially in the presence of trace amounts of copper, iron, and alkaline environments, generating irreversible hydrolysis product 2,3-diketogulonic acid, and the hydrolysis rate has a great relationship with factors such as concentration, temperature, light, and pH, making it difficult to maintain an effective state for a long time to fully exert the skin care effect.

[0003] Pearl powder, as a traditional and widely recognized natural skin care ingredient, is rich in various amino acids, trace elements and other nutrients, and has many benefits such as nourishing the skin, refining pores, and whitening, and has long occupied an important position in skin care products.

[0004] Although there are many skin care products containing VC or pearl powder on the market at present, there are few solutions to apply the whitening composition combining VC and its derivatives with pearl powder to ointment products. Existing related products often have difficulty effectively overcoming the poor stability of VC and its derivatives, or the difficulty in synergizing with other ingredients in the formula, resulting in the easy loss of active ingredients of VC and its derivatives during storage and use, and being unable to continuously and stably provide the desired whitening, antioxidant and other effects for the skin. In view of this, there is an urgent need to develop an innovative ointment product containing pearl powder and VC and its derivatives, which overcomes the defect of insufficient stability of VC and its derivatives by adopting specific formula and process technologies, enables it to stably exist in the ointment system, and fully exerts the synergistic skin care advantages of the two, providing consumers with an efficient, stable and high-quality skin care choice. Summary of the Invention

[0005] The present application provides a whitening composition and a preparation method thereof, which have good stability.

[0006] The embodiments of the present application are implemented as follows:

[0007] In a first aspect, the present application provides a whitening composition, which includes vitamin C and its derivatives, pearl powder, oil, and an oil gel combined by hydrogen bonds. The oil gel combined by hydrogen bonds includes a cross-linked polymer, and the mass ratio of the oil gel combined by hydrogen bonds to the active ingredients is 1:1 to 2, and the active ingredients include vitamin C and its derivatives and pearl powder.

[0008] In the above technical solution, the whitening composition of the present application uses an organogel combined by hydrogen bonds to build a dense network structure, and the active ingredients and oils are dispersed in the dense network structure, so that the active ingredients and oils are locked, thereby realizing a relatively stable "protection system" for the active ingredients; the unique structure of the organogel can effectively block external adverse factors, greatly maintaining the chemical structure integrity of the active ingredients, ensuring that vitamin C and its derivatives can stably exist and continuously release their effects during the storage and use period of the product, providing reliable and long-lasting whitening, antioxidant and other skin care effects for users, improving the stability of the whitening composition, expanding the product application range and usage experience, so that it can not only meet the needs of consumers with different skin types for whitening, anti-aging and other effects in daily skin care, but also be applicable to use in a variety of complex environments. For example, in the environmental conditions of different seasons and different regions, it can still maintain a good product state; at the same time, the whitening composition with an ointment texture usually has good moisturizing and moisturizing properties. In addition, the whitening composition of the present application uses vitamin C and its derivatives and pearl powder as active ingredients in combination. Pearl powder itself is rich in various natural amino acids, trace elements and other ingredients beneficial to the skin, and can complement each other with vitamin C and its derivatives in the ointment system and act on multiple levels of the skin together. It can not only exert the nourishing and repairing effects of pearl powder, but also rely on the whitening and antioxidant properties of vitamin C and its derivatives to comprehensively improve the health state of the skin.

[0009] In some possible embodiments, the organogel combined by hydrogen bonds includes at least one of castor oil-IPDI copolymer, hydrogenated castor oil-sebacic acid copolymer, dextrin palmitate, dextrin myristate and hydrogenated castor oil.

[0010] In the above technical solution, the above organogel can form a stable network structure in the oil phase to suspend the powder and stabilize the active ingredients.

[0011] In some possible embodiments, vitamin C and its derivatives include vitamin C and / or vitamin C derivatives; wherein, the vitamin C derivatives include at least one of 3-O-ethyl ascorbic acid, ascorbyl glucoside, ascorbyl palmitate, magnesium ascorbyl phosphate and sodium ascorbyl phosphate.

[0012] In the above technical solution, the above vitamin C and its derivatives have excellent antioxidant properties, can effectively inhibit melanin production, brighten the skin tone, and at the same time promote collagen synthesis.

[0013] In some possible embodiments, the Dv50 particle size of the pearl powder is 50 nm to 100 nm.

[0014] In the above technical solution, pearl powder with a Dv50 particle size within the above range is selected and added to the whitening composition of the present application. Since the pearl powder is relatively fine, it is beneficial to improve the usability of the whitening composition.

[0015] In some possible embodiments, the oil includes a first oil and a second oil;

[0016] Among them, the first oil includes at least one of olive oil, squalane, sweet almond oil, and jojoba seed oil;

[0017] The second oil includes at least one of triglyceride caprylate / caprate, dicaprylyl carbonate, and Limnanthes alba seed oil.

[0018] In the above technical solution, the above first oil and second oil have good stability, compatibility, and solubility in active ingredients.

[0019] In some possible embodiments, the whitening composition includes 0.1 wt% to 10 wt% of vitamin C and its derivatives, 3 wt% to 5 wt% of pearl powder, 70 wt% to 80 wt% of oil, and 8 wt% to 13 wt% of an oil gel bonded by hydrogen bonds.

[0020] In a second aspect, the present application provides a method for preparing a whitening composition, which includes: first mixing the active ingredients and the first oil to obtain a first mixture, then mixing the oil gel bonded by hydrogen bonds and the second oil and heating to dissolve to obtain a second mixture, and mixing and emulsifying the first mixture and the second mixture. Among them, the active ingredients include vitamin C and its derivatives and pearl powder, the oil gel bonded by hydrogen bonds includes a cross-linked polymer, and the mass ratio of the oil gel bonded by hydrogen bonds to the active ingredients is 1:1 to 2.

[0021] In the above technical solution, the preparation method of the whitening composition of the present application is simple. It adopts the oil gel suspension technology, selects oil gels combined by hydrogen bonds to build a dense network structure, and the active ingredients and oils are dispersed in the dense network structure, so that the active ingredients and oils are locked, thereby realizing the construction of a relatively stable "protection system" for the active ingredients; the unique structure of the oil gel can effectively block external adverse factors, maintaining the chemical structure integrity of the active ingredients to a great extent, ensuring that vitamin C and its derivatives can stably exist and continuously release their efficacy during the storage and use period of the product, providing reliable and long-lasting skin whitening, antioxidant and other skin care effects for users, improving the stability of the whitening composition, expanding the product application range and usage experience, so that it can meet the needs of consumers with different skin types for skin whitening, anti-aging and other effects in daily skin care, and can also be applicable to use in a variety of complex environments. For example, in the environmental conditions of different seasons and different regions, it can still maintain a good product state; at the same time, the whitening composition with an ointment texture usually has good moisturizing and moisturizing properties. In addition, the whitening composition of the present application uses vitamin C and its derivatives and pearl powder as active ingredients in combination. Pearl powder itself is rich in various natural amino acids, trace elements and other ingredients beneficial to the skin, and can complement each other with vitamin C and its derivatives in the ointment system, acting on multiple levels of the skin together, being able to exert the nourishing and repairing effects of pearl powder, and also being able to utilize the skin whitening and antioxidant characteristics of vitamin C and its derivatives to comprehensively improve the health state of the skin.

[0022] In some possible embodiments, the method of mixing the active ingredient and the first oil includes: mixing the active ingredient and the first oil and performing a grinding treatment to make the particle size of the first mixture be 5 μm to 10 μm.

[0023] In the above technical solution, the preparation method of the whitening composition of the present application first performs a grinding treatment on the active ingredient powder and the first oil, which can increase the specific surface area of the active ingredient powder, so that the active ingredient can provide more "contact surfaces", enabling the active ingredient to better adhere to the skin surface during the use of the whitening composition, and being beneficial to penetrate into the deep layer of the skin, thereby significantly optimizing the interaction process between the active ingredient and the skin, enabling the active ingredients to be more efficiently absorbed and utilized by the skin, thus enhancing the overall skin care effect of the product, and enabling the skin to more fully enjoy the multiple benefits of pearl powder nourishing the skin and the skin whitening and antioxidant properties of vitamin C and its derivatives.

[0024] In some possible embodiments, the mass ratio of the active ingredient to the first oil is 1:1 to 2.

[0025] In some possible embodiments, the step of mixing and emulsifying the first mixture and the second mixture includes: using a homogenizer to mix the first mixture and the second mixture at a rotation speed of 3000 r / min to 6000 r / min for 10 min to 15 min to form an emulsion. Description of the Drawings

[0026] To more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present application, and thus should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative efforts.

[0027] Figure 1 It is a process flow chart of the preparation method of the whitening composition of the embodiment of the present application. Detailed Description of the Embodiments

[0028] The embodiments of the present application will be described in detail below in conjunction with the embodiments. However, those skilled in the art will understand that the following embodiments are only used to illustrate the present application and should not be regarded as limiting the scope of the present application. For those not specified in the embodiments, they are carried out under conventional conditions or conditions recommended by the manufacturer. Those reagents or instruments not specified by the manufacturer can be obtained as conventional products through commercial purchase.

[0029] The following specifically describes a whitening composition and its preparation method according to an embodiment of the present application:

[0030] The present application provides a whitening composition, which includes vitamin C and its derivatives, pearl powder, oil, and an oil gel combined by hydrogen bonds. The mass ratio of the oil gel combined by hydrogen bonds to the active ingredients is 1:1 to 2, and the active ingredients include vitamin C and its derivatives and pearl powder.

[0031] As an example, the mass ratio of the oil gel combined by hydrogen bonds to the active ingredients can be 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9, or 1:2.

[0032] Among them, vitamin C and its derivatives include vitamin C and / or vitamin C derivatives. Vitamin C derivatives include at least one of 3-O-ethyl ascorbic acid, ascorbyl glucoside, ascorbyl palmitate, magnesium ascorbyl phosphate, and sodium ascorbyl phosphate. The mass proportion of vitamin C and its derivatives in the whitening composition is 0.1 wt% to 10 wt%.

[0033] It should be noted that among vitamin C and its derivatives

[0034] Optionally, vitamin C and its derivatives include vitamin C and vitamin C derivatives, and the mass percentage of vitamin C in the whitening composition is 5 wt% - 9 wt%, and the mass percentage of vitamin C derivatives in the whitening composition is 1% - 3%.

[0035] As an example, the mass percentage of vitamin C and its derivatives in the whitening composition can be 0.1 wt%, 0.5 wt%, 1 wt%, 2 wt%, 5 wt% or 10 wt%.

[0036] Optionally, the mass percentage of vitamin C and its derivatives in the whitening composition is 1 wt% - 10 wt%.

[0037] The above-mentioned vitamin C and its derivatives have excellent antioxidant properties, can effectively inhibit melanin production, brighten the skin tone, and at the same time promote collagen synthesis.

[0038] The pearl powder is preferably high-quality fresh water pearl powder, and its Dv50 particle size is 50 nm - 100 nm. The mass percentage of pearl powder in the whitening composition is 3 wt - 5 wt%.

[0039] Selecting pearl powder with a Dv50 particle size in the above range and adding it to the whitening composition of the present application, because the pearl powder is relatively delicate, it is beneficial to improve the use feeling of the whitening composition.

[0040] As an example, the mass percentage of pearl powder in the whitening composition can be 3 wt%, 3.5 wt%, 4 wt%, 4.5 wt% or 5 wt%.

[0041] The oil includes a first oil and a second oil. Among them, the first oil includes at least one of olive oil, squalane, sweet almond oil and jojoba oil, and the second oil includes at least one of caprylic / capric triglyceride, dicaprylyl carbonate and Limnanthes alba seed oil. The mass percentage of the oil in the whitening composition is 70 wt% - 80 wt%.

[0042] The above-mentioned first oil and second oil have good stability, compatibility and solubility for active ingredients.

[0043] As an example, the mass percentage of the oil in the whitening composition can be 70 wt%, 71 wt%, 72 wt%, 73 wt%, 74 wt%, 75 wt%, 76 wt%, 77 wt%, 78 wt%, 79 wt% or 80 wt%.

[0044] The hydrogen-bonded organogel is an organogel formed by hydrogen bonding, which includes a cross-linked polymer. The hydrogen-bonded organogel includes at least one of castor oil-IPDI copolymer, hydrogenated castor oil-sebacic acid copolymer, dextrin palmitate, dextrin myristate, and hydrogenated castor oil. The mass percentage of the hydrogen-bonded organogel in the whitening composition is 8wt% - 13wt%.

[0045] The above organogel can form a stable network structure in the oil phase to suspend the powder and stabilize the active ingredient.

[0046] As an example, the mass percentage of the hydrogen-bonded organogel in the whitening composition is 8wt%, 9wt%, 10wt%, 11wt%, 12wt% or 13wt%.

[0047] Please refer to Figure 1 , this application also provides a method for preparing a whitening composition, which includes the following steps:

[0048] S1. Prepare the first mixture

[0049] Mix the active ingredient and the first oil and conduct a grinding treatment so that the particle size of the first mixture is 5μm - 10μm.

[0050] Optionally, the grinding treatment includes grinding with a three-roll mill. The grinding treatment includes high-speed grinding, medium-speed grinding, and low-speed grinding in sequence, and the rotation speed of high-speed grinding is greater than that of medium-speed grinding which is greater than that of low-speed grinding.

[0051] Optionally, the mass ratio of the active ingredient to the first oil is 1:1 - 2.

[0052] As an example, the mass ratio of the active ingredient to the first oil can be 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9 or 1:2.

[0053] S2. Prepare the second mixture

[0054] Heat the second oil to above the melting point of the hydrogen-bonded organogel. The second oil is in a flowing state. Add the hydrogen-bonded organogel to the second oil and stir at a stirring rate of 10r / min - 20r / min for 10min - 20min until the hydrogen-bonded organogel is completely melted and evenly dispersed.

[0055] S3. Prepare the whitening composition

[0056] Keep stirring, slowly add the first mixture to the obtained second mixture, and use a homogenizer to mix the first mixture and the second mixture at a rotation speed of 3000 r / min to 6000 r / min for 10 min to 15 min to form an emulsion, and then cool it to room temperature.

[0057] In a first aspect, the whitening composition and its preparation method of the present application are simple. It adopts an oil gel suspension technology, selects oil gels combined by hydrogen bonds to build a dense network structure, and the active ingredients and oils are dispersed in the dense network structure, so that the active ingredients and oils are locked, thereby realizing the construction of a relatively stable "protection system" for the active ingredients; the unique structure of the oil gel can effectively block external adverse factors, and greatly maintains the chemical structure integrity of the active ingredients, ensuring that vitamin C and its derivatives can stably exist and continuously release their efficacy during the storage and use period of the product, providing users with reliable and long-lasting whitening, antioxidant and other skin care effects, and improving the stability of the whitening composition.

[0058] In a second aspect, the whitening composition and its preparation method of the present application expand the product application scope and user experience. Since the stability problem of vitamin C and its derivatives is solved and the effect of the active ingredients is optimized, the ointment product of the present application has a wider adaptability in actual application scenarios. It can not only meet the needs of consumers with different skin types for whitening, anti-aging and other effects in daily skin care, but also be applicable to use in a variety of complex environments. For example, in the environmental conditions of different seasons and different regions, it can still maintain a good product state; at the same time, the whitening composition with an ointment texture usually has good moisturizing and moisturizing properties. Compared with some traditional aqueous skin care products containing vitamin C and its derivatives, the ointment product of the present application can form a moisturizing protective film on the skin surface during the application process, bringing a comfortable skin feeling experience to the user, and avoiding the problem of dry skin after use caused by the volatile characteristics of aqueous products, further improving the overall quality and market competitiveness of the product.

[0059] In a third aspect, the whitening composition of the present application uses vitamin C and its derivatives and pearl powder as active ingredients in combination. Pearl powder itself is rich in various natural amino acids, trace elements and other ingredients beneficial to the skin, and can complement vitamin C and its derivatives in the ointment system, acting on multiple levels of the skin together. It can not only exert the nourishing and repairing effects of pearl powder, but also utilize the whitening and antioxidant properties of vitamin C and its derivatives to comprehensively improve the health status of the skin. Moreover, the raw materials selected are strictly screened, and the preparation process pays attention to the stability and compatibility of each component. The entire ointment product has high safety while ensuring the efficacy, meeting the safety standard requirements related to cosmetics, and allowing consumers to use it with confidence. This is also a major advantage compared to some existing technologies where the quality of the product may be affected by the deterioration of ingredients due to stability problems.

[0060] In a fourth aspect, the preparation method of the whitening composition of the present application first grinds the active ingredient powder and the first oil, which can increase the specific surface area of the active ingredient powder. As a result, the active ingredient can provide more "contact surfaces", enabling it to better adhere to the skin surface during the use of the whitening composition and facilitating penetration into the deep layers of the skin. Furthermore, it significantly optimizes the interaction process between the active ingredient and the skin, allowing the active ingredients to be more efficiently absorbed and utilized by the skin, thereby enhancing the overall skin care efficacy of the product and enabling the skin to more fully enjoy the multiple benefits of pearl powder nourishing the skin and the whitening and antioxidant properties of vitamin C and its derivatives.

[0061] Therefore, the whitening composition of the present application can be an ointment skin care product containing pearl powder and vitamin C and its derivatives with excellent performance, reliable efficacy and safety.

[0062] The following further describes in detail a whitening composition and its preparation method of the present application in conjunction with examples.

[0063] Example 1

[0064] The embodiment of the present application provides a whitening composition and its preparation method, which include the following steps:

[0065] S1. Raw material preparation

[0066] Select high-quality fresh water pearls, grind them to a DV50 particle size of 50 nm to 100 nm with ultra-fine grinding, and the purity reaches more than 95% as pearl powder; select 3-O-ethylascorbic acid as the vitamin C derivative; select olive oil as the first oil, and select caprylic / capric triglyceride, dicaprylyl carbonate and Limnanthes alba seed oil in a mass ratio of 2:3:2 as the second oil; select dextrin palmitate as the oil gel combined by hydrogen bonds.

[0067] The raw materials include 8 wt% vitamin C, 1.8 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0068] S2. Prepare the first mixture

[0069] Mix the pearl powder, ascorbic acid (vitamin C) powder and 3 - O - ethyl ascorbic acid powder, then place them in a three - roll mill. Add the first oil to the three - roll mill and conduct high - speed grinding, medium - speed grinding and low - speed grinding in sequence at 30°C. The rotation speed of high - speed grinding is 30 rpm / min, the rotation speed of medium - speed grinding is 20 rpm / min, and the rotation speed of low - speed grinding is 8 rpm / min. Grind for a total of 40 min to obtain the first mixture.

[0070] S3. Prepare the second mixture

[0071] Heat the second oil to 85°C. The second oil is in a flowing state. Slowly add dextrin palmitate to the second oil and stir at a stirring rate of 15 r / min for 20 min until the dextrin palmitate is completely melted and evenly dispersed to obtain the second mixture.

[0072] S4. Prepare the whitening composition

[0073] While maintaining the stirring state, slowly add the first mixture to the obtained second mixture. Use a homogenizer to mix the first mixture and the second mixture at a rotation speed of 4000 r / min for 15 min to form an emulsion, and then cool to room temperature to obtain an ointment - like whitening composition.

[0074] Example 2

[0075] This application example provides a whitening composition and its preparation method. Based on Example 1, the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 1 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0076] Example 3

[0077] This application example provides a whitening composition and its preparation method. Based on Example 1, the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 3 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0078] Example 4

[0079] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 5 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0080] Example 5

[0081] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 8 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0082] Example 6

[0083] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the vitamin C derivative to sodium ascorbyl phosphate and the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 1 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0084] Example 7

[0085] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the vitamin C derivative to sodium ascorbyl phosphate and the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 3 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0086] Example 8

[0087] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the vitamin C derivative to sodium ascorbyl phosphate and the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 5 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0088] Example 9

[0089] An embodiment of the present application provides a whitening composition and a preparation method thereof. On the basis of Example 1, the vitamin C derivative is changed to sodium ascorbyl phosphate and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 8 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bonds, 15 wt% first oil and 57.2 wt% second oil.

[0090] Example 10

[0091] An embodiment of the present application provides a whitening composition and a preparation method thereof. On the basis of Example 1, the vitamin C derivative is changed to ascorbyl palmitate and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 1 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bonds, 15 wt% first oil and 57.2 wt% second oil.

[0092] Example 11

[0093] An embodiment of the present application provides a whitening composition and a preparation method thereof. On the basis of Example 1, the vitamin C derivative is changed to ascorbyl palmitate and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 3 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bonds, 15 wt% first oil and 57.2 wt% second oil.

[0094] Example 12

[0095] An embodiment of the present application provides a whitening composition and a preparation method thereof. On the basis of Example 1, the vitamin C derivative is changed to ascorbyl palmitate and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 5 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bonds, 15 wt% first oil and 57.2 wt% second oil.

[0096] Example 13

[0097] An embodiment of the present application provides a whitening composition and a preparation method thereof. On the basis of Example 1, the vitamin C derivative is changed to ascorbyl palmitate and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 8 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bonds, 15 wt% first oil and 57.2 wt% second oil.

[0098] Example 14

[0099] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the vitamin C derivative is changed to ascorbyl glucoside and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 1 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0100] Example 15

[0101] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the vitamin C derivative is changed to ascorbyl glucoside and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 3 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0102] Example 16

[0103] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the vitamin C derivative is changed to ascorbyl glucoside and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 5 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0104] Example 17

[0105] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the vitamin C derivative is changed to ascorbyl glucoside and the ratio of raw materials is changed. The raw materials include 8 wt% vitamin C, 8 wt% vitamin C derivative, 5 wt% pearl powder, 13 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 57.2 wt% second oil.

[0106] Example 18

[0107] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the first oil is changed to squalane and the total grinding time is 20 min.

[0108] Example 19

[0109] An embodiment of the present application provides a whitening composition and a preparation method thereof. Based on Example 1, the first oil is changed to squalane and the total grinding time is 40 min.

[0110] Example 20

[0111] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to squalane on the basis of Example 1, and the total grinding time is 60 min.

[0112] Example 21

[0113] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to sweet almond oil on the basis of Example 1, and the total grinding time is 20 min.

[0114] Example 22

[0115] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to sweet almond oil on the basis of Example 1, and the total grinding time is 40 min.

[0116] Example 23

[0117] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to sweet almond oil on the basis of Example 1, and the total grinding time is 60 min.

[0118] Example 24

[0119] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to jojoba seed oil on the basis of Example 1, and the total grinding time is 20 min.

[0120] Example 25

[0121] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to jojoba seed oil on the basis of Example 1, and the total grinding time is 40 min.

[0122] Example 26

[0123] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the first oil to jojoba seed oil on the basis of Example 1, and the total grinding time is 60 min.

[0124] Example 27

[0125] The embodiments of the present application provide a whitening composition and a preparation method thereof, which change the second oil to squalane and the ratio of raw materials on the basis of Example 1. The raw materials include 8 wt% vitamin C, 1.8 wt% vitamin C derivative, 5 wt% pearl powder, 10 wt% oil gel combined by hydrogen bond, 15 wt% first oil and 60.2 wt% second oil.

[0126] Example 28

[0127] The embodiments of the present application provide a whitening composition and a preparation method thereof. On the basis of Example 1, the oil gel combined by hydrogen bonds is changed to a hydrogenated castor oil-sebacic acid copolymer, the second oil is changed to squalane, and the ratio of raw materials is changed. The raw materials include 8 wt% of vitamin C, 1.8 wt% of vitamin C derivative, 5 wt% of pearl powder, 10 wt% of the oil gel combined by hydrogen bonds, 15 wt% of the first oil, and 60.2 wt% of the second oil.

[0128] Example 29

[0129] The embodiments of the present application provide a whitening composition and a preparation method thereof. On the basis of Example 1, the oil gel combined by hydrogen bonds is changed to a castor oil-IPDI copolymer, the second oil is changed to squalane, and the ratio of raw materials is changed. The raw materials include 8 wt% of vitamin C, 1.8 wt% of vitamin C derivative, 5 wt% of pearl powder, 10 wt% of the oil gel combined by hydrogen bonds, 15 wt% of the first oil, and 60.2 wt% of the second oil.

[0130] Example 30

[0131] The embodiments of the present application provide a whitening composition and a preparation method thereof. On the basis of Example 1, the oil gel combined by hydrogen bonds is changed to 6 wt% of dextrin palmitate and 4 wt% of hydrogenated castor oil-sebacic acid copolymer, the second oil is changed to squalane, and the ratio of raw materials is changed. The raw materials include 8 wt% of vitamin C, 1.8 wt% of vitamin C derivative, 5 wt% of pearl powder, 10 wt% of the oil gel combined by hydrogen bonds, 15 wt% of the first oil, and 60.2 wt% of the second oil.

[0132] Example 31

[0133] The embodiments of the present application provide a whitening composition and a preparation method thereof. On the basis of Example 1, the oil gel combined by hydrogen bonds is changed to 6 wt% of dextrin palmitate, 3 wt% of hydrogenated castor oil-sebacic acid copolymer and 1 wt% of castor oil-IPDI copolymer, the second oil is changed to squalane, and the ratio of raw materials is changed. The raw materials include 8 wt% of vitamin C, 1.8 wt% of vitamin C derivative, 5 wt% of pearl powder, 10 wt% of the oil gel combined by hydrogen bonds, 15 wt% of the first oil, and 60.2 wt% of the second oil.

[0134] Comparative Example 1

[0135] The comparative example of the present application provides a whitening composition and a preparation method thereof, which include the following steps:

[0136] S1. Raw material preparation

[0137] Select high-quality fresh water pearls, grind them to a DV50 particle size of 50 nm to 100 nm through ultra-fine grinding, with a purity of over 95%, as pearl powder; select 3-O-ethyl ascorbic acid as a vitamin C derivative; select olive oil as the first oil, and select triglyceride caprylate / caprate, dicaprylyl carbonate, and Limnanthes alba seed oil in a mass ratio of 2:3:2 as the second oil.

[0138] The raw materials include 8 wt% vitamin C, 1.8 wt% vitamin C derivative, 5 wt% pearl powder, 15 wt% first oil, and 70.2 wt% second oil.

[0139] S2. Prepare the first mixture

[0140] Mix the pearl powder, ascorbic acid (vitamin C) powder, and 3-O-ethyl ascorbic acid powder, then place them in a three-roll mill. Add the first oil to the three-roll mill and perform high-speed grinding, medium-speed grinding, and low-speed grinding in sequence at 30°C. The rotation speed of high-speed grinding is 30 rpm / min, the rotation speed of medium-speed grinding is 20 rpm / min, and the rotation speed of low-speed grinding is 8 rpm / min. Grind for a total of 40 min to obtain the first mixture.

[0141] S3. Prepare the whitening composition

[0142] While maintaining the stirring state, add the second oil to the obtained first mixture, and use a homogenizer to mix the first mixture and the oil at a rotation speed of 4000 r / min for 15 min to form an emulsion, and cool it to room temperature to obtain a flowing whitening composition.

[0143] Test Example 1

[0144] Take the whitening compositions of Examples 1 to 17 and Comparative Example 1 for stability testing, take the whitening compositions of Examples 18 to 26 and Comparative Example 1 for adhesion rate testing, and conduct stability testing and DPPH testing on the whitening compositions of Examples 27 to 31. The results are shown in Tables 1 to 3 respectively.

[0145] The test methods are as follows:

[0146] 1. Stability testing

[0147] Place each ointment sample in an incubator at 45°C to simulate a high-temperature environment, and detect the color change of the ointment at 0 d, 7 d, 14 d, and 28 d.

[0148] 2. Adhesion rate testing

[0149] The attachment rate of the active ingredient in each ointment sample was tested. Take 1.0 g of the ointment sample, add 10 mL of n-hexane (to dissolve the oil matrix), shake for 5 min, centrifuge at 4000 rpm for 15 min. The precipitate is pearl powder, VC, and VC derivatives. Add 10 mL of extraction solvent to the precipitate, sonicate, centrifuge and take the supernatant, and test by HPLC. Calculate the attachment rate. Attachment rate (%) = [C×V / (m×P)]×100%, where C is the concentration measured by HPLC (μg / ml), V is the volume of constant volume (ml), m is the sample mass (g), and P is the labeled content of the raw material (μg / g).

[0150] 3. DPPH Test

[0151] The ointment samples were placed in an environment with a light intensity of (1.47×10^6 Lux hr) and irradiated for 0 d, 7 d, 14 d, and 28 d respectively. Weigh 0.5 g of the ointment sample, add 5 ml of (anhydrous ethanol-Tween 80 mixed solution (3:1, v / v)), shake in a water bath at 60°C for 10 min, centrifuge at 6000 rpm for 15 min, and take the supernatant for standby. Verify the extraction efficiency by HPLC (C18 chromatographic column, mobile phase 0.1% phosphoric acid solution: methanol = 95:5), which is greater than 85%; dilute the extract with ethanol to gradient concentrations of 0.2 / 0.5 / 1.0 / 2.0 / 4.0 mg / mL. Take 2 mL of the sample solution + 2 mL of DPPH solution → vortex and mix well, let stand in the dark for 45 minutes, centrifuge (5000 rpm, 15 min) to remove the undissolved oil, take the supernatant and measure the absorbance at 517 nm, and calculate the scavenging rate.

[0152] Table 1 Stability test results of the whitening compositions of Examples 1 to 17 and Comparative Example 1

[0153]

[0154]

[0155] Table 2 Attachment rate test results of the whitening compositions of Examples 18 to 26

[0156] Item Adhesion rate (%) Example 18 83.2 Example 19 91.6 Example 20 87.3 Example 21 78.9 Example 22 85.2 Example 23 83.1 Example 24 81.9 Example 25 87.9 Example 26 88.5

[0157] Table 3 DPPH test results of the whitening compositions of Examples 27 to 31

[0158]

[0159] As can be seen from the examples of this application, the whitening composition of the examples of this application is in paste form and has good stability, while the whitening composition prepared in Comparative Example 1 is in fluid form and has poor stability.

[0160] As can be seen from Examples 1 to 17, the stability of sodium ascorbyl phosphate is the best at a concentration of 1 wt%, the stabilities of 3-O-ethyl ascorbic acid and ascorbyl palmitate are relatively good at a concentration of 3 wt%, and ascorbyl glucoside is relatively stable at a concentration of 5 wt%.

[0161] As can be seen from Examples 18 to 26, when squalane is used and the grinding time is 40 minutes, the attachment rate of the active ingredient is the highest. At the same time, these ointments were subjected to sensory evaluation, including the smoothness and greasiness during application. Considering comprehensively, it was determined that squalane and a grinding time of 40 minutes are an optimal combination.

[0162] As can be seen from Examples 27 to 31, when squalane is used as the oil-phase matrix, and the addition amounts of dextrin palmitate, hydrogenated castor oil / sebacic acid, and castor oil / IPDI copolymer are 6 wt%, 3 wt%, and 2 wt% of the mass of the oil-phase matrix respectively, the ointment has the best effect on the photo-stability protection of VC derivatives. In the antioxidant performance test (DPPH free radical scavenging experiment) of these ointments, it was found that the ointment prepared under this combination has strong antioxidant ability, which further proves the important influence of the adjustment of the oil gel system on the product performance and also provides a basis for the further optimization of the ointment formula.

[0163] The above are only specific embodiments of the present application and are not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. A whitening composition, characterized in that: The whitening composition comprises vitamin C and its derivatives, pearl powder, oil and oil gel bonded by hydrogen bonds; The hydrogen-bonded oil gel comprises a cross-linked polymer, and the mass ratio of the hydrogen-bonded oil gel to the active ingredient is 1:1-2, and the active ingredient comprises the vitamin C and its derivatives and the pearl powder.

2. The whitening composition according to claim 1, characterized in that The hydrogen-bonded oil gel comprises at least one of castor oil-IPDI copolymer, hydrogenated castor oil-sebacic acid copolymer, dextrin palmitate, dextrin myristate and hydrogenated castor oil.

3. The whitening composition according to claim 1, characterized in that The vitamin C and its derivatives include vitamin C and / or vitamin C derivatives; Wherein, the vitamin C derivative includes at least one of 3-o-ethyl ascorbic acid, ascorbyl glucoside, ascorbyl palmitate, magnesium ascorbyl phosphate and sodium ascorbyl phosphate.

4. The whitening composition according to claim 1, characterized in that The Dv50 particle size of the pearl powder is 50nm to 100nm.

5. The whitening composition according to claim 1, characterized in that The grease includes a first grease and a second grease; Wherein, the first oil comprises at least one of olive oil, squalane, sweet almond oil and jojoba seed oil; The second oil comprises at least one of caprylic / capric triglyceride, dicaprylyl carbonate and meadowfoam seed oil.

6. The whitening composition according to claim 1, characterized in that The whitening composition comprises 0.1 wt% to 10 wt% of the vitamin C and its derivatives, 3 wt% to 5 wt% of the pearl powder, 70 wt% to 80 wt% of the oil and 8 wt% to 13 wt% of the oil gel bonded by hydrogen bonds.

7. A method for preparing a whitening composition, characterized in that: The preparation method of the whitening composition comprises: firstly mixing the active ingredient with a first oil to prepare a first mixture, then mixing the oil gel bonded by hydrogen bonds with a second oil and heating to dissolve to prepare a second mixture, and then mixing and emulsifying the first mixture and the second mixture; The active ingredients include vitamin C and its derivatives and pearl powder, the hydrogen-bonded oil gel includes a cross-linked polymer, and the mass ratio of the hydrogen-bonded oil gel to the active ingredients is 1:1-2.

8. The method for preparing the whitening composition according to claim 7, characterized in that: The method of mixing the active ingredient with the first oil comprises: mixing the active ingredient with the first oil and performing a grinding process so that the particle size of the first mixture is 5 μm to 10 μm.

9. The method for preparing the whitening composition according to claim 7, characterized in that: The mass ratio of the active ingredient to the first oil is 1:1-2.

10. The method for preparing the whitening composition according to claim 7, characterized in that: The step of mixing and emulsifying the first mixture and the second mixture includes: using a homogenizer to mix the first mixture and the second mixture at a rotation speed of 3000 r / min to 6000 r / min for 10 min to 15 min to form an emulsion.

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