A florfenicol-doxycycline compound preparation and a preparation method thereof

A florfenicol-doxycycline compound preparation was prepared by encapsulation with cyclodextrin and polyacrylamide network, which solved the problems of inconvenient operation and environmental pollution of florfenicol-doxycycline injection and achieved efficient and stable drug blending and antibacterial effect.

CN120131674BActive Publication Date: 2026-03-20HANGZHOU SHANGNI BIOPHARMACEUTICAL R&D CO LTD
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Patent Information

Application Number
CN202510552245.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-04-29
Publication Date
2026-03-20
Estimated Expiration
2045-04-29

AI Technical Summary

Technical Problem

The existing florfenicol-doxycycline injection is inconvenient to use in clinical practice, and its production process is prone to environmental pollution and high cost. It is also difficult to achieve the blending and stability issues of water-soluble and lipid-soluble drugs.

Method used

A florfenicol-doxycycline compound formulation was prepared by cyclodextrin inclusion and polyacrylamide network encapsulation. Florfenicol and doxycycline hydrochloride were loaded into porous microparticles by granulation technology. Cyclodextrin and nano-silica were used as excipients to improve solubility and stability.

Benefits of technology

The stability and solubility of florfenicol-doxycycline combination preparations have been improved, production costs have been reduced, antibacterial effects have been enhanced, the duration of drug action in animals has been prolonged, and clinical treatment effects have been significant.

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Abstract

The present application relates to the technical field of pharmaceutical preparation, and in particular to a florfenicol-doxycycline compound preparation and a preparation method thereof.The raw materials of the florfenicol-doxycycline compound preparation include, by mass fraction, 5-10 parts of florfenicol, 5-20 parts of doxycycline hydrochloride, 20-40 parts of inclusion material, 8-14 parts of pullulan, 1-3 parts of nano-silicon dioxide, 1-5 parts of glycerol, 1-2 parts of emulsifier, 0.1-0.3 parts of genipin, 20-60 parts of filler, 0.1-1 parts of surfactant, and 0.1-1 parts of lubricant.The present application combines the use of florfenicol and doxycycline hydrochloride, and the effect is better than that of single use;meanwhile, the granulation method and the auxiliary materials used improve the solubility of florfenicol, and the florfenicol-doxycycline compound preparation can be administered by mixed feeding or drinking water, and is convenient for clinical use.
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