Traditional Chinese medicine composition for treating male asthenospermia and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating male asthenospermia and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises prepared rehmannia root, semen cuscutae, raspberry, fructus lycii, schisandra chinensis, semen plantaginis, astragalus membranaceus, Chinese yam, cistanche, herba epimedii and deer-horn glue, the traditional Chinese medicine composition is decocted into decoction or added into boiled honey to be prepared into pills, and the medicine for treating male asthenospermia is obtained. The composition has the advantages of small and precise dosage, small side effect, high safety and low cost. Experimental results show that the traditional Chinese medicine composition can be effectively applied to treatment of male asthenozoospermia due to male kidney essence deficiency, the total effective rate reaches up to 91.67% or above, and the traditional Chinese medicine composition has obvious advantages in improvement of clinical traditional Chinese medicine symptoms compared with western medicines. The invention provides a novel pharmaceutical composition for treating male asthenospermia, and the pharmaceutical composition has practical clinical significance and popularization value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and particularly to a traditional Chinese medicine composition for treating male asthenospermia, and its preparation method and application. Background Art

[0002] Male asthenospermia is a common disease in the urology and andrology outpatient clinic, and the main clinical manifestations are sparse semen and poor sperm motility. The main cause of male infertility is male asthenospermia. However, in the existing technology, there is still a lack of effective therapeutic drugs for male asthenospermia, and the treatment mainly relies on empirical drugs. The surgical indications and curative effects are very limited. Although assisted reproduction solves some fertility problems, there are still defects such as low success rate, high cost, medical ethics and genetic risks.

[0003] Therefore, how to provide an effective method for treating male asthenospermia is a technical problem that needs to be urgently solved by those skilled in the art. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating male asthenospermia, and its preparation method and application, so as to solve the problems existing in the above-mentioned prior art. The traditional Chinese medicine components provided by the present invention are scientific, with reasonable compatibility, complementing each other, and having the excellent effects of nourishing yin and strengthening yang, and tonifying the kidney and generating essence. Clinically used for treating male asthenospermia, it shows remarkable curative effects, characterized by high safety, no toxic and side effects, and stable and lasting curative effects, achieving a comprehensive treatment effect of treating both the symptoms and the root causes, and bringing an innovative breakthrough in the treatment field of male asthenospermia.

[0005] To achieve the above purpose, the present invention provides the following solutions:

[0006] The present invention provides a traditional Chinese medicine composition for treating male asthenospermia, which includes the following drugs in parts by weight:

[0007] 15 - 20 parts of Rehmannia glutinosa, 15 - 20 parts of Cuscuta chinensis, 10 - 15 parts of Rubus idaeus, 10 - 15 parts of Lycium barbarum, 10 - 20 parts of Schisandra chinensis, 15 - 30 parts of Plantago asiatica, 15 - 30 parts of Astragalus membranaceus, 15 - 30 parts of Dioscorea opposita, 15 - 20 parts of Cistanche deserticola, 15 - 20 parts of Epimedium brevicornu, and 10 - 15 parts of Cornu Cervi Colla.

[0008] Preferably, it includes the following drugs in parts by weight:

[0009] 20 parts of Rehmannia glutinosa, 20 parts of Cuscuta chinensis, 10 parts of Rubus idaeus, 10 parts of Lycium barbarum, 20 parts of Schisandra chinensis, 15 parts of Plantago asiatica, 30 parts of Astragalus membranaceus, 20 parts of Dioscorea opposita, 20 parts of Cistanche deserticola, 20 parts of Epimedium brevicornu, and 10 parts of Cornu Cervi Colla.

[0010] Preferably, it includes the following drugs in parts by weight:

[0011] 17 - 20 parts of Rehmannia glutinosa preparata, 17 - 20 parts of Cuscuta chinensis, 10 - 13 parts of Rubus idaeus, 10 - 13 parts of Lycium barbarum, 13 - 20 parts of Schisandra chinensis, 15 - 23 parts of Plantago asiatica, 17 - 30 parts of Astragalus membranaceus, 15 - 27 parts of Dioscorea opposita, 17 - 20 parts of Cistanche deserticola, 17 - 20 parts of Epimedium brevicornu, and 10 - 13 parts of Cornu Cervi Colla.

[0012] The present invention provides an application of the traditional Chinese medicine composition in the preparation of a drug for improving male sperm activity and sperm density.

[0013] The present invention also provides an application of the traditional Chinese medicine composition in the preparation of a drug for treating male asthenospermia.

[0014] Preferably, the asthenospermia is asthenospermia of kidney essence deficiency syndrome.

[0015] The present invention also provides a drug for treating male asthenospermia, and the raw materials of the drug include the traditional Chinese medicine composition.

[0016] Preferably, the dosage form of the drug is decoction or pill.

[0017] The present invention also provides a preparation method of the drug. When the drug is decoction, the preparation method includes: weighing the traditional Chinese medicine composition, mixing, adding water, soaking, decocting, filtering, separately collecting the filtrate and the residue, adding water to the residue, decocting, filtering, and combining the two filtrates to obtain the drug;

[0018] Wherein, the soaking time is 30 min; the mass ratio of the traditional Chinese medicine composition to water is 1:6; the mass ratio of the residue to water is 1:4;

[0019] The decocting includes: heating to boiling, and maintaining a slightly boiling state for heating for 30 min.

[0020] The present invention also provides a preparation method of the drug. When the drug is pill, the preparation method includes:

[0021] weighing the traditional Chinese medicine composition, pulverizing, mixing to obtain a mixed powder; heating honey to boiling for 3 min, adding the mixed powder to the boiling honey, and kneading to form pill grains to obtain the drug;

[0022] Wherein, the mass ratio of the traditional Chinese medicine composition to the honey is 2.5:1; the single - grain weight of the pill grains is 2 g.

[0023] The present invention discloses the following technical effects:

[0024] The present invention discloses a traditional Chinese medicine composition for treating male asthenospermia, its preparation method and application. Compared with western medicine, the present invention has less and more precise dosage, less side effects, high safety, and low cost, and can be effectively applied to the treatment of male asthenospermia caused by kidney essence deficiency syndrome, with a total effective rate of over 91.67%. The traditional Chinese medicine composition provided by the present invention has obvious advantages over western medicine especially in improving clinical TCM syndromes, is an innovation in the drugs for treating male asthenospermia, and has practical clinical significance and promotion value. Detailed Embodiments

[0025] The various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, characteristics, and implementation embodiments of the present invention.

[0026] It should be understood that the terms used in the present invention are only for describing specific embodiments and are not used to limit the present invention. Additionally, for the numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0027] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention pertains. Although the present invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0028] Without departing from the scope or spirit of the present invention, various improvements and changes can be made to the specific embodiments of the present invention specification, which are obvious to those skilled in the art. Other embodiments obtained from the specification of the present invention are obvious to those skilled in the art. The specification and embodiments of the present invention are only exemplary.

[0029] Regarding the use of "comprising", "including", "having", "containing", etc. in this article, they are all open-ended terms, meaning including but not limited to.

[0030] In the traditional Chinese medicine formula of the present invention, Rehmannia glutinosa is used as the monarch drug. Its nature and flavor are sweet and slightly warm, and it specifically enters the liver and kidney meridians. It is good at tonifying the kidney and nourishing yin, and is even more capable of replenishing essence and marrow. As recorded in "Compendium of Materia Medica", it can "fill the marrow... generate essence and blood, and supplement the deficiencies of internal injuries of the five zang-organs"; the ministerial drugs include Cuscuta chinensis and Lycium barbarum. Cuscuta chinensis is famous for tonifying the kidney and assisting yang, and strengthening the spleen and replenishing essence. Its nature is "warm but not dry, tonifying without stagnation". As praised in "Fengyuan of Materia Medica", its specialty lies in "benefiting the essence and marrow, strengthening the muscles and bones, and stopping spermatorrhea and emission"; Lycium barbarum is an excellent product for nourishing the liver and kidney, and also has the effect of nourishing blood and calming the mind. It is good at replenishing essence and blood. The adjuvant drugs are Cornu Cervi Colla, Rubus chingii, Schisandra chinensis, Astragalus membranaceus, Epimedium brevicornu, and Cistanche deserticola. Cornu Cervi Colla, as a product with vital essence of blood and flesh, can warm the kidney yang and tonify the kidney essence; Rubus chingii is sweet and sour in flavor and slightly warm in nature, and has a significant effect on tonifying the kidney and consolidating essence, reducing urination and stopping enuresis. It can be said that it is "warming the kidney without being dry, consolidating essence without coagulation"; Schisandra chinensis benefits qi and promotes the production of body fluid, consolidates essence and tonifies the kidney; Astragalus membranaceus strengthens the spleen and replenishes qi; Epimedium brevicornu and Cistanche deserticola supplement essence and blood, benefit the liver and kidney, and assist yang qi. The guiding drug is Plantago asiatica, which can clear the wind-heat of the liver and lung, guide the water pathogen of the bladder, promote diuresis without damaging healthy qi, combine astringency with dredging, and tonify without stagnation. The combination of the above-mentioned drugs has the effects of warming the kidney yang, benefiting the liver and spleen, and regulating qi and blood, so as to achieve the effect of strengthening essence. In the whole formula, the monarch, ministerial, adjuvant, and guiding drugs are used exquisitely, and the compatibility is scientific and reasonable, jointly achieving the effects of nourishing yin and yang, and tonifying the kidney and filling essence.

[0031] In addition, according to modern medicine, the glycoside compounds and carrier saponins in the prepared Rehmannia root of the present invention have been experimentally verified to significantly enhance the activity of superoxide dismutase, catalase, etc. in mouse blood, showing excellent antioxidant efficacy. On the other hand, the main active substance of Cuscuta chinensis, flavonoid compounds, have performed well in improving male reproductive function. Many studies have confirmed that Cuscuta chinensis can effectively enhance sperm motility, which is specifically reflected in improving the motility index, movement speed and capillary penetration value of sperm. In addition, the water extract of Cuscuta chinensis can significantly increase the activity of superoxide dismutase in sperm suspension, while reducing the content of lipid peroxides such as malondialdehyde, providing protection for the damage of sperm membrane, acrosome structure and mitochondrial function caused by reactive oxygen; as for raspberry, the study of its water extract revealed that it can reduce the secretion of hypothalamic luteinizing hormone-releasing hormone (LHRH) by the hypothalamus of rats, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the pituitary gland, and leading to a decrease in estradiol levels. Lycium barbarum polysaccharides (LBP) are rich in Lycium barbarum polysaccharides. LBP can not only increase the number and activity of sperm, but also improve the reproductive function of rats with kidney yang deficiency symptoms. In addition, LBP can effectively resist the DNA damage of testicular cells induced by reactive oxygen free radicals with its antioxidant effect, thereby maintaining the normal structure and function of testicular cells; Schisandra polysaccharides have a therapeutic effect on rats with spermatogenesis disorders caused by cyclophosphamide (CTX). It was found that it can restore the balanced regulation of the hypothalamus-pituitary-gonad axis, promote the normal secretion of sex hormones, accelerate the regeneration process of testicular tissue cells, and significantly improve the number and quality of sperm, thereby optimizing the spermatogenesis function of the testis; Astragalus, Epimedium, Cistanche deserticola, etc. can increase the activity and content of superoxide dismutase in the testis, effectively counteracting the oxidative emergency damage of germ cells and sperm. At the same time, Cistanche deserticola, Epimedium, Lycium barbarum, Cuscuta chinensis, etc. can promote the secretion of testosterone by regulating the function of the hypothalamus-pituitary-testis axis to promote the production and maturation of sperm. Epimedium can also promote cell proliferation. The Chinese medicinal ingredients in this recipe can regulate the key reproductive regulation system of the hypothalamus-pituitary-gonadal axis (HPG). HPG is the reproductive center of humans. The gonadotropin-releasing hormone (GnRH) secreted by the hypothalamus acts as a messenger to stimulate the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Follicle-stimulating hormone is responsible for the spermatogenic cells in the testicles to initiate spermatogenesis, and luteinizing hormone can regulate the production of testosterone by the interstitial cells of the testicles to maintain normal spermatogenesis. This recipe also shows a strong ability to resist oxidative stress, which can increase the activity of superoxide dismutase (SOD) and effectively reduce the content of malondialdehyde, thereby significantly enhancing the antioxidant defense mechanism. This effect is of great significance for improving the production function of spermatogenic cells and the secretory function of supporting cells; it can also inhibit the abnormal opening of the sperm mitochondrial permeability transition pore, increase the level of mitochondrial membrane potential, and reduce the apoptosis of spermatogenic cells.

[0032] The traditional Chinese medicine components of the present invention are scientific, with reasonable compatibility, complementing each other, and having the excellent effects of nourishing yin and strengthening yang, and tonifying the kidney to generate essence. Clinically used for the treatment of male asthenospermia, it shows remarkable curative effects. Its characteristics lie in high safety, no toxic and side effects, and stable and lasting curative effects, achieving a comprehensive treatment effect of treating both the symptoms and the root causes, bringing an innovative breakthrough in the treatment field of male asthenospermia.

[0033] Example 1

[0034] 1. A traditional Chinese medicine composition for treating male asthenospermia, comprising the following raw materials in parts by weight:

[0035] 20 parts of Rehmannia glutinosa, 20 parts of Cuscuta chinensis, 10 parts of Rubus idaeus, 10 parts of Lycium barbarum, 20 parts of Schisandra chinensis, 15 parts of Plantago asiatica, 30 parts of Astragalus membranaceus, 20 parts of Dioscorea opposita, 20 parts of Cistanche deserticola, 20 parts of Epimedium brevicornu, and 10 parts of Cornu Cervi Colla.

[0036] 2. A preparation method of a traditional Chinese medicine composition for treating male asthenospermia, the traditional Chinese medicine composition being a decoction, and the preparation process comprising the following steps:

[0037] Mix the raw medicinal materials, add 6 times the mass of water, soak for 30 minutes, first decoct with strong fire until boiling, then change to slow fire and decoct for 30 minutes, then filter, collect the filtrate, and then add water to the residue in a mass ratio of 1:4 of the residue to water, repeat the above-mentioned decocting and filtering steps, and mix the two filtrates to obtain the decoction of the traditional Chinese medicine composition.

[0038] Example 2

[0039] A preparation method of a traditional Chinese medicine composition for treating male asthenospermia, different from Example 1, the traditional Chinese medicine composition being pills, and the preparation process comprising the following steps:

[0040] Crush the above raw materials respectively with a pulverizer, and fully mix the raw material powders with a pestle in a mortar. Then heat and boil the honey for 3 minutes, and then add the mixed raw material powders to the boiled honey, wherein the mass ratio of the raw medicinal materials to the honey is 2.5:1. Knead the mixture of honey and the mixed raw material powders to make pill grains with a mass of 2 g per grain, and thus obtain the pills of the traditional Chinese medicine composition.

[0041] Example 3

[0042] A traditional Chinese medicine composition for treating male asthenospermia, different from Example 1, comprising the following raw materials in parts by weight:

[0043] 17 parts of Rehmannia glutinosa, 15 parts of Cuscuta chinensis, 13 parts of Rubus idaeus, 13 parts of Lycium barbarum, 10 parts of Schisandra chinensis, 30 parts of Plantago asiatica, 15 parts of Astragalus membranaceus, 15 parts of Dioscorea opposita, 17 parts of Cistanche deserticola, 17 parts of Epimedium brevicornu, and 13 parts of Cornu Cervi Colla.

[0044] Example 4

[0045] A traditional Chinese medicine composition for treating asthenospermia in men. Different from Example 1, it comprises raw materials in the following parts by weight:

[0046] 15 parts of Rehmannia glutinosa, 17 parts of Cuscuta chinensis, 15 parts of Rubus idaeus, 15 parts of Lycium barbarum, 13 parts of Schisandra chinensis, 23 parts of Plantago asiatica, 17 parts of Astragalus membranaceus, 30 parts of Dioscorea opposita, 15 parts of Cistanche deserticola, 15 parts of Epimedium brevicornu, and 15 parts of Cornu Cervi Colla.

[0047] Control Example 1

[0048] The difference from Example 1 is only that Astragalus membranaceus is not included in the raw materials.

[0049] Control Example 2

[0050] The difference from Example 1 is only that Cistanche deserticola and Epimedium brevicornu are not included in the raw materials.

[0051] Control Example 3

[0052] The difference from Example 1 is only that Cuscuta chinensis and Lycium barbarum are not included in the raw materials.

[0053] Effect Verification Example 1

[0054] Gonadal inhibition was induced in rats by using tripterygium glycosides tablets to obtain model rats.

[0055] The model rats were divided into a blank control group, a levocarnitine group (oral liquid, Northeast Pharmaceutical General Factory, specification 10 mL: 1 g), an Example 1 group, and Control Example 1 - 3 groups, a total of 6 groups, with 6 rats in each group for a control study.

[0056] The levocarnitine group was administered 2 times a day (after conversion of the rat administration dose: 0.36 mL by gavage each time), and the traditional Chinese medicine groups (Example 1 group, Control Example 1 - 3 groups) were administered one dose a day, orally in two divided doses. The blank control group received no treatment.

[0057] The treatment process lasted for 4 weeks. The results are shown in Tables 1 and 2. The research results show that both the levocarnitine group and the Example 1 group had significant increases in semen concentration and sperm motility compared with the blank control group, and the differences were statistically significant (P < 0.05).

[0058] Table 1 Sperm concentration before and after treatment (×10 6 / mL)

[0059]

[0060] Table 2 PR + NP (%) before and after treatment

[0061]

[0062] Effect Verification Example 2

[0063] 1. Experimental methods

[0064] 1.1 Case data

[0065] ① Aged 20 - 45 years old, with normal sexual life, normal fertility of the female partner, and not pregnant after more than 1 year of marriage without taking any contraceptive measures;

[0066] ② Meeting the diagnosis of male asthenospermia;

[0067] ③ Meeting the diagnosis of kidney deficiency and sperm depletion syndrome.

[0068] The male patients with asthenospermia in the observed cases were randomly divided into a treatment group and a control group, with 36 cases in each group. The control group was given levocarnitine oral solution, and the treatment group was given the traditional Chinese medicine composition decoction for treating male asthenospermia prepared in Example 1 of the present invention. The treatment course for both groups was 3 months, and the clinical efficacy and the changes in semen indexes were evaluated after 1 treatment course.

[0069] 1.2 Diagnostic criteria

[0070] 1.2.1 Diagnostic criteria for traditional Chinese medicine syndromes

[0071] Main syndromes: ① Few sperm; ② Weak motility; ③ Low survival rate;

[0072] Sub - syndromes: ① Soreness and weakness in the waist and knees; ② Fatigue, spermatorrhea, premature ejaculation, frequent urination at night, forgetfulness, tinnitus; ③ Whitish tongue coating, weak pulse;

[0073] Diagnosis: The diagnosis is established when 3 main syndromes and 2 or more sub - syndromes are present.

[0074] 1.2.2 Western medicine diagnostic criteria (male asthenospermia)

[0075] ① Total sperm count less than 3.9×10 7 / ejaculation;

[0076] ② Sperm concentration < 1.5×10 7 / mL;

[0077] ③ Total sperm motility (PR + NP) < 40% or progressive motility (PR) < 32%.

[0078] The diagnosis of male asthenospermia can be made only when the diagnostic criteria of ①②③ are met.

[0079] 1.3 Treatment plan

[0080] The treatment group took the traditional Chinese medicine prepared in Example 1 of the present invention, 2 times a day, 200 - 300 mL each time, and took it warm 2 hours after breakfast and dinner for 3 months. The curative effect was statistically analyzed after 1 course of treatment. The control group took Levocarnitine Oral Solution (General Pharmaceutical Factory of Northeast Pharmaceutical) 1 vial (containing 1 g of levocarnitine) each time, 2 times a day, orally. During the treatment of each group, raw and cold, greasy, and spicy foods were prohibited.

[0081] 1.4 Diagnostic criteria for curative effect

[0082] Semen indexes were detected before and after treatment respectively. Abstinence for 2 - 7 days was required before the examination, and semen was collected by masturbation; after the semen was incubated at 37°C for liquefaction, routine semen analysis was performed using an automatic sperm analyzer in accordance with the standards recommended by the WHO. It mainly included grade a sperm, (a + b) grade sperm, sperm motility rate, and sperm density.

[0083] 1.5 Criteria for judging curative effect:

[0084] 1.5.1 Refer to the relevant standards in the "Standard Examination and Diagnosis Manual for Infertile Couples" to evaluate the clinical curative effect:

[0085] Cured: The spouse became pregnant;

[0086] Markedly effective: Sperm motility returned to normal [(a + b) grade ≥ 50%, or a grade > 25%, sperm motility rate ≥ 60%];

[0087] Effective: Sperm motility was improved [(a + b) grade > 30%, or a grade increased by > 30%, sperm motility rate increased by > 30%];

[0088] Ineffective: Sperm motility was not improved, or the degree of improvement did not reach the effective standard.

[0089] 1.5.2 Refer to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines" to formulate the criteria for judging the curative effect of traditional Chinese medicine:

[0090] Cured: The clinical symptoms of kidney yang deficiency disappeared before and after treatment, and the syndrome score decreased by ≥ 95%.

[0091] Markedly effective: The clinical symptoms of kidney yang deficiency were significantly improved before and after treatment, and the syndrome score decreased by 70% - 94%.

[0092] Effective: The clinical symptoms and signs of kidney yang deficiency were improved before and after treatment, and the syndrome score decreased by 30% - 69%.

[0093] Ineffective: The symptoms of kidney yang deficiency were not significantly improved before and after treatment, and the syndrome score decreased by less than 30%.

[0094] 1.6 Statistical method

[0095] Statistical methods: The experimental data were statistically analyzed using SPSS 10.0 software. Measurement data were expressed as x±s and the t-test was used; ranked data were analyzed using the Ridit analysis. All statistical tests were two-sided tests, and P≤0.05 was considered statistically significant.

[0096] 2. Treatment results

[0097] According to the above treatment plan, the treatment group and the control group were orally administered the traditional Chinese medicine composition decoction in Example 1 of the present invention and levocarnitine oral solution respectively to treat 72 patients with male asthenospermia. After 1 course of treatment, the curative effect was statistically analyzed. Among them, 10 patients in the treatment group were clinically cured, 12 were markedly effective, 10 were effective, and 3 were ineffective. The total number of effective cases was 33, accounting for 91.67%. In the control group, 5 patients were clinically cured, 9 were markedly effective, 15 were effective, and 7 were ineffective. The total number of effective cases was 29, accounting for 80.56%.

[0098] The total effective rates of the treatment group and the control group were 91.67% and 80.56% respectively; there was a statistically significant difference in the clinical efficacy between the groups (P>0.05). When comparing within the groups before and after treatment, there were statistically significant differences in grade a sperm, (a + b) grade sperm, sperm motility rate, and sperm density (P<0.05). When comparing between the groups after treatment, there were statistically significant differences in grade a sperm and sperm density (P<0.05). The treatment group was superior to the control group.

[0099] The results of the present invention show that the total effective rate of the treatment group is 91.67%. Its clinical efficacy is comparable to that of the western medicine control group (P>0.05), and it has an obvious advantage in increasing sperm density (P<0.05). It is suggested that the traditional Chinese medicine composition for treating male asthenospermia in Example 1 of the present invention can be effectively used for the treatment of male asthenospermia and has the value of clinical popularization and application.

[0100] The above-described embodiments are only descriptions of the preferred embodiments of the present invention and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicine composition for treating male asthenospermia, characterized in that: According to weight, it includes the following drugs: 15-20 parts of Rehmannia root, 15-20 parts of Cuscuta seed, 10-15 parts of Rubus idaeus, 10-15 parts of Lycium barbarum, 10-20 parts of Schisandra chinensis, 15-30 parts of Plantago seed, 15-30 parts of Astragalus, 15-30 parts of Dioscorea opposita, 15-20 parts of Cistanche deserticola, 15-20 parts of Epimedium and 10-15 parts of Deer Horn Glue.

2. The Chinese medicine composition according to claim 1, characterized in that According to weight, it includes the following drugs: 17-20 parts of Rehmannia root, 17-20 parts of Cuscuta seed, 10-13 parts of Rubus idaeus, 10-13 parts of Lycium barbarum, 13-20 parts of Schisandra chinensis, 15-23 parts of Plantago seed, 17-30 parts of Astragalus, 15-27 parts of Dioscorea opposita, 17-20 parts of Cistanche deserticola, 17-20 parts of Epimedium and 10-13 parts of Deer Horn Glue.

3. The Chinese medicine composition according to claim 1, characterized in that: According to weight, it includes the following drugs: 20 parts of Radix Rehmanniae Preparata, 20 parts of Semen Cuscutae, 10 parts of Fructus Rubi, 10 parts of Fructus Lycii, 20 parts of Fructus Schisandrae Chinensis, 15 parts of Semen Plantaginis, 30 parts of Radix Astragali, 20 parts of Rhizoma Dioscoreae, 20 parts of Herba Cistanches, 20 parts of Herba Epimedii and 10 parts of Deer Horn Glue.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for improving male sperm activity and sperm density.

5. Use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating male asthenospermia.

6. The use according to claim 5, characterized in that The asthenospermia is asthenospermia due to kidney essence deficiency.

7. A drug for treating male asthenospermia, characterized in that: The raw materials of the medicine include the Chinese medicine composition according to any one of claims 1-3.

8. The drug according to claim 7, characterized in that The dosage form of the medicine is decoction or pill.

9. A method for preparing the drug according to claim 8, characterized in that: When the medicine is a decoction, the preparation method comprises: weighing the Chinese medicine composition, mixing, adding water, soaking, decocting, filtering, collecting the filtrate and the filter residue respectively, adding water to the filter residue, decocting, filtering, and combining the two filtrates to obtain the medicine; Wherein, the soaking time is 30 minutes; the mass ratio of the Chinese medicine composition to water is 1:6; the mass ratio of the filter residue to water is 1:4; The decoction comprises: heating to boil, and keeping the heating in a slightly boiling state for 30 minutes.

10. A method for preparing the drug according to claim 8, characterized in that: When the drug is a pill, the preparation method comprises: Weigh the Chinese medicine composition, crush it, mix it, and obtain a mixed powder; heat and boil the honey for 3 minutes, add the mixed powder into the boiled honey, and knead it into pellets to obtain the medicine; Among them, the mass ratio of the traditional Chinese medicine composition to the honey is 2.5:1; and the weight of a single pellet is 2g.

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