Traditional Chinese medicine compound composition for promoting wound healing of type II diabetes mellitus, gel preparation and preparation method and application of gel preparation

Abstract

The invention relates to the technical field of traditional Chinese medicine wound surface repairing, in particular to a traditional Chinese medicine compound composition for repairing type II diabetes mellitus wounds, a gel preparation and a preparation method and application of the traditional Chinese medicine compound composition and the gel preparation. According to the traditional Chinese medicine compound composition suitable for repairing the type II diabetes wound, starting from a diabetes refractory wound, active substances such as astragaloside, tea polyphenol and the like are compatible with blood glucose reducing traditional Chinese medicines for the first time, and a matrix material formed by glycerol, carbomer and chitosan is matched, so that the traditional Chinese medicine compound composition suitable for repairing the type II diabetes wound is finally obtained. And the effect of the traditional Chinese medicine composition is better than that of clinical common healing-promoting medicine diabetic foot ointment.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine wound repair, and particularly relates to a traditional Chinese medicine compound composition, a gel preparation, a preparation method and an application thereof for promoting the wound healing of type II diabetes. Background Art

[0002] The wound surface of diabetic foot is difficult to heal, which is one of the common complications in the late stage of diabetes, and the prognosis is poor. Among them, about 14% - 24% of patients need to undergo amputation surgery, which brings great physical and mental blows to patients and their families.

[0003] The existing clinical treatment methods for diabetic foot generally involve dressing after clinical routine disinfection and debridement. Common dressings include anionic dressings, growth factor gel dressings, etc. Among them, the anionic dressing only has an antibacterial effect, and the growth factor gel dressing usually only has the effect of promoting wound healing. It can be seen that the existing dressings for diabetic foot wound surfaces have the problems of independent and relatively single functions.

[0004] In view of this, the present invention is specifically proposed. Summary of the Invention

[0005] In order to solve the above technical problems, the present invention provides a traditional Chinese medicine compound composition for repairing the wound surface of type II diabetes wounds, a preparation method and an application thereof.

[0006] Specifically, the technical solution of the present invention is as follows: In the first aspect, the present invention provides a traditional Chinese medicine compound composition for promoting the wound healing of type II diabetes, and the raw material formula thereof includes components in the following dosage ratios: 0.4 - 0.6 parts by mass of tea polyphenols, 0.12 - 0.20 parts by mass of astragaloside, 2.0 - 2.8 parts by mass of liquorice, 4.6 - 5.0 parts by mass of lithospermum, 5.2 - 6.0 parts by mass of angelica, 6.0 - 6.8 parts by mass of coptis, 3.2 - 4.0 parts by mass of Chinese prickly ash, 12 - 14 parts by mass of honeysuckle, 8 - 12 parts by mass of dragon's blood, 6 - 7.5 parts by mass of earthworm, 0.7 - 0.9 parts by mass of menthol ice, 1.2 - 1.5 parts by mass of carbomer, 0.3 - 0.35 parts by mass of chitosan, 6 - 8 parts by volume of glycerol, 25 - 35 parts by volume of propylene glycol, 2.5 - 3.5 parts by volume of polyethylene glycol; wherein, when the unit of the parts by mass is g, the unit of the parts by volume is mL.

[0007] The present invention aims to provide a multifunctional dressing for patients, which can not only resist infection, promote wound healing, fill and conform to irregular wounds, but also absorb exudative substances. Based on the prescription of Shenjing Zhike Pills (Jiangtang Pills) in the Pharmacopoeia (which are composed of ten natural traditional Chinese medicines such as Astragalus membranaceus, Coptis chinensis, and Glycyrrhiza uralensis respectively, and these drugs have significant curative effects in the clinical practice, especially for type II diabetes patients, and have certain effects of replenishing qi and nourishing yin, promoting fluid production and quenching thirst), functional components such as astragaloside IV and tea polyphenols are added, and carbomer, chitosan, and glycerol are used as matrices to finally prepare a gel-like external dressing preparation, so as to repair type II refractory wounds and achieve the treatment of internal diseases by external treatment.

[0008] In the present invention, carbomer and chitosan have high liquid absorption, are soft and moisturizing, which is beneficial to provide a moist environment for the wound and can fill irregular wounds; by adding three matrices of glycerol, carbomer, and chitosan, the compatibility is reasonable, making the traditional Chinese medicine compound ointment lubricating, non-irritating, with appropriate consistency, easy to apply on the skin, stable in nature, without incompatibility changes with the main drug, having water absorption, capable of absorbing wound secretions, not interfering with the normal functions of the skin, having good drug release performance, and being easy to wash off, etc.; the semi-solid external preparation with a certain consistency prepared by uniformly mixing with tea polyphenols, astragaloside IV, and traditional Chinese medicine stock solution can mainly promote the healing of diabetic wounds, and at the same time has the effects of clearing heat and anti-inflammation, promoting the generation of new blood vessels and nerve endings in the wound area, having good local wound sterilization effect, being convenient to use, non-irritating, non-damaging, non-allergic to the skin, fast-acting, and having significant curative effects. Through the efficacy observation and verification on the mouse model of type 2 diabetes wounds, this drug has good antibacterial activity, can inhibit excessive inflammation, moisten the wound, promote collagen deposition in the wound area, and has the effect of promoting the healing of type II diabetes wounds.

[0009] Preferably, in the present invention, the raw material formula includes components with the following dosage ratios: 0.4 - 0.5 parts by mass of tea polyphenols, 0.12 - 0.16 parts by mass of astragaloside IV, 2.0 - 2.4 parts by mass of Glycyrrhiza uralensis, 4.6 - 4.8 parts by mass of Lithospermum erythrorhizon, 5.2 - 5.6 parts by mass of Angelica sinensis, 6.0 - 6.4 parts by mass of Coptis chinensis, 3.2 - 3.6 parts by mass of Zanthoxylum bungeanum, 12 - 12.8 parts by mass of Lonicera japonica, 8 - 10 parts by mass of Sanguis draxonis, 6 - 6.69 parts by mass of Pheretima aspergillum, 0.7 - 0.8 parts by mass of menthol camphor, 1.2 - 1.36 parts by mass of carbomer, 0.3 - 0.32 parts by mass of chitosan, 6 - 7 parts by volume of glycerol, 25 - 30 parts by volume of propylene glycol, and 2.5 - 3 parts by volume of polyethylene glycol.

[0010] Another preferred embodiment of the present invention is that the raw material formula comprises components in the following dosage proportions: 0.5 - 0.6 parts by mass of tea polyphenols, 0.16 - 0.20 parts by mass of astragaloside IV, 2.4 - 2.8 parts by mass of liquorice, 4.8 - 5.0 parts by mass of lithospermum root, 5.6 - 6.0 parts by mass of angelica sinensis, 6.4 - 6.8 parts by mass of coptis chinensis, 3.6 - 4.0 parts by mass of Chinese prickly ash, 12.8 - 14 parts by mass of honeysuckle flower, 10 - 12 parts by mass of dragon's blood, 6.69 - 7.5 parts by mass of earthworm, 0.8 - 0.9 parts by mass of menthol camphor, 1.36 - 1.5 parts by mass of carbomer, 0.32 - 0.35 parts by mass of chitosan, 7 - 8 parts by volume of glycerol, 30 - 35 parts by volume of propylene glycol, and 3 - 3.5 parts by volume of polyethylene glycol.

[0011] In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine compound composition, which includes the step of mixing each raw material according to the parts by weight; before mixing each raw material according to the parts by weight, the following processing steps are further included: placing liquorice, lithospermum root, angelica sinensis, coptis chinensis, Chinese prickly ash, honeysuckle flower and dragon's blood in water and boiling them over medium heat for 20 - 40 minutes, adding earthworm, and then turning to low heat and simmering for 40 - 80 minutes (frying until the inside is yellow and the outside is charred, and removing the medicinal residues); filtering and then cooling for later use.

[0012] Preferably, in the present invention, liquorice, lithospermum root and angelica sinensis are sliced before processing, the slicing thickness of liquorice is 2 - 4 mm, and the slicing thickness of angelica sinensis or lithospermum root is 1 - 2 mm; And / or, coptis chinensis and menthol camphor are pulverized before processing; wherein, the pulverizing particle size of coptis chinensis is 80 ± 10 mesh; the pulverizing particle size of menthol camphor is 60 ± 10 mesh.

[0013] Preferably, in the present invention, the preparation method includes the following steps: (1) Placing liquorice, lithospermum root, angelica sinensis, coptis chinensis, Chinese prickly ash, honeysuckle flower and dragon's blood in water and boiling them over medium heat for 20 - 40 minutes, adding earthworm, and then turning to low heat and simmering for 40 - 80 minutes; filtering and then cooling; (2) Adding tea polyphenols, astragaloside IV, menthol camphor, chitosan, glycerol, propylene glycol and polyethylene glycol to the cooled traditional Chinese medicine stock solution, and mixing evenly; (3) Adding carbomer and water to the evenly mixed material, and standing still under ultraviolet light for 1.5 - 2.5 hours.

[0014] Further preferably, in step (2), the volume ratio of the traditional Chinese medicine stock solution to glycerol is 15 - 25:6 - 8, preferably 20:7.

[0015] Further preferably, in step (3), the dosage proportion of carbomer and water is 1.2 - 1.5 g:15 - 25 mL, preferably 1.36 g:20 mL.

[0016] Further preferably, the volume of the traditional Chinese medicine stock solution after decocting in step (1) is 10%-16% of the volume of water used before decocting.

[0017] Further preferably, the concentration of tea polyphenols in the traditional Chinese medicine compound composition is 0.5%-0.75%.

[0018] Further preferably, the concentration of astragaloside IV in the traditional Chinese medicine compound composition is 0.15%-0.25%.

[0019] Further preferably, the concentration of carbomer in the traditional Chinese medicine compound composition is 1.5%-2.0%.

[0020] In a third aspect, the present invention provides the use of the traditional Chinese medicine compound composition or the preparation method in the preparation of a product for promoting the wound healing of type II diabetes; the product can be selected as a gel preparation, or a derivative product obtained by supplementing the gel preparation with a medically acceptable carrier.

[0021] Beneficial effects: The present invention provides a traditional Chinese medicine compound composition for repairing type II diabetic wound surfaces, its preparation method and application. Starting from the intractable diabetic wounds, the present invention first combines active substances such as astragaloside IV and tea polyphenols with hypoglycemic traditional Chinese medicines, and cooperates with a matrix material formed by glycerol, carbomer and chitosan, and finally obtains a traditional Chinese medicine compound composition suitable for repairing type II diabetic wounds, and proves that it has better effects than the clinically commonly used wound healing drug diabetic foot ointment. Description of the drawings

[0022] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following will describe the drawings required to be used in the examples or the description of the prior art.

[0023] Figure 1 It is a flow chart for preparing the traditional Chinese medicine compound gel preparation of the present invention.

[0024] Figure 2 It is a HE staining diagram of type II diabetic skin wounds of mice on the fourteenth day of the present invention.

[0025] Figure 3 It is a diagram of the repair state of type II diabetic skin wounds of mice on the fourteenth day of the present invention. Specific embodiments

[0026] The present invention provides a traditional Chinese medicine compound gel formula capable of promoting the wound healing of type II diabetes and its preparation method. The traditional Chinese medicine compound gel can promote the wound healing of type II diabetes, and at the same time has the effects of clearing heat and reducing inflammation, and promoting the generation of new blood vessels and nerve endings in the wound area.

[0027] In one of the more specific embodiments provided by the present invention, the present invention provides the following technical solution: a formula for a traditional Chinese medicine compound gel that can promote the wound healing of type II diabetes, comprising the following raw materials: tea polyphenols, astragaloside IV, licorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, dragon's blood, earthworm, menthol, carbomer, chitosan, glycerin, propylene glycol, polyethylene glycol, and the ratio is carried out according to the following weights and components: 0.5 grams of tea polyphenols, 0.16 grams of astragaloside IV, 2.4 grams of licorice, 4.8 grams of lithospermum, 5.6 grams of angelica, 6.4 grams of coptis, 3.6 grams of Chinese prickly ash, 12.8 grams of honeysuckle, 10 grams of dragon's blood, 6.69 grams of earthworm, 0.8 grams of menthol, 1.36 grams of carbomer, 0.32 grams of chitosan, 7 milliliters of glycerin, 30 milliliters of propylene glycol, 3 milliliters of polyethylene glycol.

[0028] The present invention provides a preparation method for the above-mentioned formula of the traditional Chinese medicine compound gel preparation that can promote the wound healing of type II diabetes, including Step 1, preliminary processing; Step 2, grinding and sterilization of medicinal materials; Step 3, boiling the original Chinese medicine liquid; Step 4, adding active ingredients and stirring; Step 5, gel synthesis; Step 6, internal and external packaging.

[0029] Among them, in the above Step 1, the cleaning of various medicinal materials is done well. The staff in the dispensing room should select the qualified tea polyphenols, astragaloside IV, licorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, dragon's blood, earthworm, menthol, carbomer, chitosan, glycerin, propylene glycol, polyethylene glycol according to the formula requirements. The staff extracts the processed medicinal materials in full amount in the ultra-clean workbench.

[0030] Among them, in the above Step 2, the staff cuts licorice, lithospermum, and angelica into thin slices, pulverizes coptis into coarse powder, pulverizes menthol into fine powder, and performs ultraviolet disinfection for 30 minutes.

[0031] Among them, in the above Step 3, the staff pours the prepared licorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, and dragon's blood into a clean pot, boils it with high heat for 30 minutes, adds earthworm and turns to slow fire to boil for 60 minutes, filters and cools it, and seals it for later use.

[0032] Among them, in the above Step 4, 20 mL of the prepared original Chinese medicine liquid is taken, and tea polyphenols, astragaloside IV, menthol, chitosan, glycerin, propylene glycol, and polyethylene glycol are added thereto, and stirred evenly.

[0033] Among them, in the above Step 5, the mixture in Step 4 is added with carbomer and 20 mL of water at room temperature, and left to stand and swell under ultraviolet light for 2 hours to obtain the gel finished product.

[0034] Among them, in the above Step 6, the staff performs internal packaging before the gel is completely solidified. After the internal packaging, the outer box packaging is carried out after the gel is solidified, and it is stored in a cool, ventilated, and dry area.

[0035] Preferably, when screening the medicinal materials in step one, remove the soil and soil dust in the medicinal materials, and perform low-temperature and drying treatments on the main high-quality forage.

[0036] Preferably, when decocting the Chinese medicine stock solution in step three, add 1500 mL of water in total, and obtain 200 mL of Chinese medicine stock solution in total when the decoction is completed.

[0037] Preferably, the concentration of added tea polyphenols in step four is 0.625%, and the concentration of added astragaloside IV is 0.2%.

[0038] Preferably, the concentration of added carbomer in step five is 1.7%.

[0039] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions in the present invention will be described clearly and completely below. Obviously, the described embodiments are some embodiments of the present invention, rather than all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the scope of protection of the present invention.

[0040] At the endpoints and any value in the ranges disclosed in this specification, these ranges or values are not limited to the exact ranges or values. These ranges or values should be understood to include values close to these ranges or values. For numerical ranges, between the endpoint values of each range, between the endpoint values of each range and individual point values, and between individual point values, they can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be regarded as specifically disclosed herein.

[0041] In the description of this specification, the descriptions with reference to the terms "one embodiment", "some embodiments", "specific implementation manners", or "some specific implementation manners", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the embodiments of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without conflict, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0042] In the embodiments provided in this specification, for those without specifying specific techniques or conditions, follow the techniques or conditions described in the literature in this field or follow the product instructions. For the reagents or instruments without indicating the manufacturer, they are all conventional products that can be obtained through regular channels.

[0043] In the present invention, the expression of "medium heat" can be selected according to the following standards: the unit heat is about 5760 kJ / h; the power is 1600 W, and the temperature range is 170 - 200 °C; the expression of "gentle heat" can be selected according to the following standards: the unit heat is about 1440 kJ / h; the power is 400 W, and the temperature range is 60 - 100 °C.

[0044] Example 1 This example provides a traditional Chinese medicine compound gel that can promote the wound healing of type II diabetes. Its formula includes the following raw materials: tea polyphenols, astragaloside IV, liquorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, dragon's blood, earthworm, menthol camphor, carbomer, chitosan, glycerol, propylene glycol, polyethylene glycol, and the ratio is carried out according to the following weights and components: 0.5 grams of tea polyphenols, 0.16 grams of astragaloside IV, 2.4 grams of liquorice, 4.8 grams of lithospermum, 5.6 grams of angelica, 6.4 grams of coptis, 3.6 grams of Chinese prickly ash, 12.8 grams of honeysuckle, 10 grams of dragon's blood, 6.69 grams of earthworm, 0.8 grams of menthol camphor, 1.36 grams of carbomer, 0.32 grams of chitosan, 7 milliliters of glycerol, 30 milliliters of propylene glycol, and 3 milliliters of polyethylene glycol.

[0045] This example provides a preparation method of the above traditional Chinese medicine compound gel. Refer to Figure 1 , and specifically includes the following steps: Step 1, preliminary processing: Do a good job in cleaning all kinds of medicinal materials. The staff in the dispensing room should select the qualified tea polyphenols, astragaloside IV, liquorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, dragon's blood, earthworm, menthol camphor, carbomer, chitosan, glycerol, propylene glycol, polyethylene glycol according to the formula requirements, and the staff should fully extract the processed medicinal materials in the ultra-clean workbench.

[0046] Step 2, grinding and sterilization of medicinal materials: The staff cut liquorice, lithospermum, and angelica into thin slices, pulverize coptis into coarse powder, and pulverize menthol camphor into fine powder, and sterilize with ultraviolet light for 30 minutes.

[0047] Step 3, boiling the traditional Chinese medicine stock solution: The staff pour the prepared liquorice, lithospermum, angelica, coptis, Chinese prickly ash, honeysuckle, and dragon's blood into a clean pot, add water and boil over high heat for 30 minutes, add earthworm and turn to gentle heat and boil for 60 minutes, filter and cool, and seal for later use.

[0048] Step 4, adding active ingredients and stirring: Take 20 mL of the prepared traditional Chinese medicine stock solution, and add tea polyphenols, astragaloside IV, menthol camphor, chitosan, glycerol, propylene glycol, and polyethylene glycol, and stir evenly.

[0049] Step 5, gel synthesis: Add carbomer and 20 mL of water to the mixture in step 4 at room temperature, and let it stand and swell under ultraviolet light for 2 hours to obtain the finished gel.

[0050] Step 6, Inner and outer packaging: The staff can directly carry out inner and outer packaging on the gel products and store them in a cool, ventilated and dry area.

[0051] Example 2 This example provides a traditional Chinese medicine compound gel that can promote the wound healing of type II diabetes. Compared with Example 1, the difference is only that the formula is proportioned according to the following weights and components: 0.4 grams of tea polyphenols, 0.12 grams of astragaloside IV, 2.0 grams of licorice, 4.6 grams of lithospermum, 5.2 grams of angelica, 6.0 grams of coptis, 3.2 grams of zanthoxylum bungeanum, 12 grams of honeysuckle, 8 grams of dragon's blood, 6 grams of earthworm, 0.7 grams of menthol ice, 1.2 grams of carbomer, 0.3 grams of chitosan, 6 milliliters of glycerol, 25 milliliters of propylene glycol, and 2.5 milliliters of polyethylene glycol.

[0052] Example 3 This example provides a traditional Chinese medicine compound gel that can promote the wound healing of type II diabetes. Compared with Example 1, the difference is only that the formula is proportioned according to the following weights and components: 0.6 grams of tea polyphenols, 0.20 grams of astragaloside IV, 2.8 grams of licorice, 5.0 grams of lithospermum, 6.0 grams of angelica, 6.8 grams of coptis, 4.0 grams of zanthoxylum bungeanum, 14 grams of honeysuckle, 12 grams of dragon's blood, 7.5 grams of earthworm, 0.9 grams of menthol ice, 1.5 grams of carbomer, 0.35 grams of chitosan, 8 milliliters of glycerol, 35 milliliters of propylene glycol, and 3.5 milliliters of polyethylene glycol.

[0053] Example 4 To further prove that the traditional Chinese medicine compound gel of the present invention has a good effect in the repair of type II diabetic wounds, the following experiment was carried out: SD mice aged 8 - 10 weeks, both male and female, were induced into a diabetic mouse model by intraperitoneal injection of streptozotocin. Then, a full - thickness skin wound with a diameter of 6 mm was made on the back of each mouse. The mice were randomly divided into a blank control group (without any other treatment), a positive control group (using a diabetic foot ointment), and a traditional Chinese medicine compound gel group (using the traditional Chinese medicine compound gel prepared in Example 1). The dressing was changed once a day. After dressing, the wound was covered with a sterile gauze and bandaged with an elastic bandage.

[0054] The results are shown in Figure 2 and Figure 3 .

[0055] As Figure 2 shown in the HE staining of the skin of type II diabetic mice on the 14th day, and as Figure 3 shown in the wound repair status map of the skin of type II diabetic mice on the 14th day, it can be seen that the HE staining of the traditional Chinese medicine compound gel group has more new blood vessels than the other two groups, and the gross view of the wound surface is smaller than that of the other two groups.

[0056] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A Chinese medicinal compound composition for promoting wound healing in type 2 diabetes, characterized in that: The raw material formula comprises the following components in the following dosage proportions: 0.4-0.6 parts by weight of tea polyphenols, 0.12-0.20 parts by weight of astragaloside IV, 2.0-2.8 parts by weight of liquorice, 4.6-5.0 parts by weight of lithospermum officinale, 5.2-6.0 parts by weight of angelica sinensis, 6.0-6.8 parts by weight of coptis root, 3.2-4.0 parts by weight of prickly ash, 12-14 parts by weight of honeysuckle, 8-12 parts by weight of dragon's blood, 6-7.5 parts by weight of earthworm, 0.7-0.9 parts by weight of mint ice, 1.2-1.5 parts by weight of carbomer, 0.3-0.35 parts by weight of chitosan, 6-8 parts by volume of glycerol, 25-35 parts by volume of propylene glycol and 2.5-3.5 parts by volume of polyethylene glycol; wherein, when the unit of the mass part is g, the unit of the volume part is mL.

2. The Chinese medicine compound composition according to claim 1, characterized in that: The raw material formula comprises the following components in the following dosage proportions: 0.4-0.5 parts by weight of tea polyphenols, 0.12-0.16 parts by weight of astragaloside IV, 2.0-2.4 parts by weight of liquorice, 4.6-4.8 parts by weight of lithospermum officinale, 5.2-5.6 parts by weight of angelica sinensis, 6.0-6.4 parts by weight of coptis root, 3.2-3.6 parts by weight of zanthoxylum bungeanum, 12-12.8 parts by weight of honeysuckle, 8-10 parts by weight of dragon's blood, 6-6.69 parts by weight of earthworm, 0.7-0.8 parts by weight of mint ice, 1.2-1.36 parts by weight of carbomer, 0.3-0.32 parts by weight of chitosan, 6-7 parts by weight of glycerol, 25-30 parts by weight of propylene glycol and 2.5-3 parts by weight of polyethylene glycol.

3. The Chinese medicine compound composition according to claim 1, characterized in that: The raw material formula comprises the following components in the following dosage proportions: 0.5-0.6 parts by weight of tea polyphenols, 0.16-0.20 parts by weight of astragaloside IV, 2.4-2.8 parts by weight of liquorice, 4.8-5.0 parts by weight of lithospermum officinale, 5.6-6.0 parts by weight of angelica sinensis, 6.4-6.8 parts by weight of coptis root, 3.6-4.0 parts by weight of zanthoxylum bungeanum, 12.8-14 parts by weight of honeysuckle, 10-12 parts by weight of dragon's blood, 6.69-7.5 parts by weight of earthworm, 0.8-0.9 parts by weight of mint ice, 1.36-1.5 parts by weight of carbomer, 0.32-0.35 parts by weight of chitosan, 7-8 parts by volume of glycerol, 30-35 parts by volume of propylene glycol and 3-3.5 parts by volume of polyethylene glycol.

4. The method for preparing the Chinese medicine compound composition according to any one of claims 1 to 3, comprising the step of mixing the raw materials in parts by weight, characterized in that: Before mixing the raw materials by weight, the following preparation steps are also included: put licorice, lithospermum officinale, angelica, coptis root, prickly ash, honeysuckle and dragon's blood in water and boil them over medium heat for 20-40 minutes, add earthworms, and simmer over low heat for 40-80 minutes; filter and cool for later use.

5. The preparation method according to claim 4, characterized in that: Licorice, Lithospermum officinale and Angelica sinensis are sliced ​​before processing. The slice thickness of licorice is 2-4 mm, and the slice thickness of Angelica sinensis or Lithospermum officinale is 1-2 mm. And / or, coptis root and mint ice are crushed before processing; wherein the particle size of the coptis root crushed is 80±10 mesh; the particle size of the mint ice crushed is 60±10 mesh.

6. The preparation method according to claim 4, characterized in that: The steps include: (1) Place licorice, lithospermum officinale, angelica, coptis root, prickly ash, honeysuckle and dragon's blood in water and boil over high heat for 20-40 minutes. Add earthworms and simmer over low heat for 40-80 minutes. Filter and let cool. (2) Add tea polyphenols, astragaloside IV, mint ice, chitosan, glycerol, propylene glycol and polyethylene glycol to the cooled traditional Chinese medicine stock solution and mix well; (3) Add carbomer and water to the mixed material and let it stand under ultraviolet light for 1.5-2.5 hours.

7. The preparation method according to claim 6, characterized in that: In step (2), the volume ratio of the Chinese medicine stock solution to glycerol is 15-25:6-8, preferably 20:7; And / or, in step (3), the ratio of carbomer to water is 1.2-1.5 g:15-25 mL, preferably 1.36 g:20 mL.

8. The preparation method according to any one of claims 4 to 7, characterized in that: The volume of the Chinese medicine stock solution after boiling in step (1) is 10%-16% of the volume of the water before boiling.

9. The preparation method according to any one of claims 4 to 8, characterized in that: The concentration of tea polyphenols in the traditional Chinese medicine compound composition is 0.5%-0.75%; And / or, the concentration of astragaloside IV in the Chinese medicine compound composition is 0.15%-0.25%; And / or, the concentration of Carbomer in the Chinese medicine compound composition is 1.5%-2.0%.

10. Use of the Chinese herbal compound composition according to any one of claims 1 to 3 or the preparation method according to any one of claims 4 to 9 in the preparation of a product for promoting wound healing in type 2 diabetes; the product may be a gel preparation, or a derivative product obtained by adding a medically acceptable carrier to the gel preparation.

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