Purification and impurity separation equipment and process for peramivir intermediate

Abstract

The invention provides purification and impurity separation equipment and process for a peramivir intermediate, and relates to the technical field of purification and impurity removal of peramivir intermediates. The purification and impurity separation equipment for the peramivir intermediate comprises a rack, an upper separation chamber is arranged on the upper portion in the rack, a lower separation chamber is arranged on the lower portion in the rack, an upper separation mechanism used for secondary purification and impurity separation of the peramivir intermediate is arranged in the upper separation chamber, and a lower separation mechanism used for secondary purification and impurity separation of the peramivir intermediate is arranged in the lower separation chamber. A lower separation mechanism used for primary purification and impurity separation of the peramivir intermediate is arranged in the lower separation chamber, and a transfer mechanism used for conveying the peramivir intermediate to the upper separation mechanism by the lower separation mechanism is arranged on one side of the rack. By means of secondary purification, the purity of the peramivir intermediate is higher, it is guaranteed that the peramivir intermediate cannot be subjected to secondary pollution through the fact that the driving mechanism and the screening mechanism are separated, and the screening efficiency is high.

Description

Technical Field

[0001] The present invention relates to the technical field of the preparation of peramivir intermediates, and specifically to an equipment and process for the purification of peramivir intermediates and the separation of impurities. Background Art

[0002] Peramivir is used to treat influenza B or influenza A, and peramivir intermediate is an intermediate product in the production of peramivir. When preparing the intermediate product of peramivir, in order to obtain better yield and purity of the intermediate, people will further remove fine particles or uncrystallized impurities by screening with a vibrating screen during production to improve the purity of the intermediate, and then obtain the intermediate. After that, through concentration, washing and crushing, the powdery peramivir intermediate is obtained.

[0003] In order to ensure that the peramivir intermediate powder does not contain more other solid impurities or derivative impurities, a screening device is used to screen and purify the peramivir intermediate again to remove the physical impurities therein, so as to achieve the final purification and impurity removal of the peramivir intermediate, and then it is applied to the production of peramivir drugs.

[0004] The efficiency of ordinary sieves is very low, so the equipment for screening peramivir intermediates usually adopts vibrating screens and other equipment. During screening, in order to make the screening efficiency higher, the machine will adopt the method of vibrating while screening to separate and purify the impurities of the peramivir intermediate. The vibration between machines will accelerate the fatigue aging and wear of the equipment structure, not only generating a lot of noise, but also the waste chips generated by the vibration and wear between machines may enter the raw materials, contaminating the peramivir intermediate. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the present invention provides an equipment and process for the purification of peramivir intermediates and the separation of impurities, which solves the problems of secondary pollution and low efficiency during the purification and impurity removal of peramivir intermediates.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: An equipment for the purification of peramivir intermediates and the separation of impurities includes a frame. An upper separation chamber is arranged in the upper part of the frame, and a lower separation chamber is arranged in the lower part of the frame. An upper separation mechanism for the second purification and impurity separation of peramivir intermediates is arranged in the upper separation chamber, a lower separation mechanism for the first purification and impurity separation of peramivir intermediates is arranged in the lower separation chamber, and a transfer mechanism for transporting peramivir intermediates from the lower separation mechanism to the upper separation mechanism is arranged on one side of the frame; The transfer mechanism includes a feeding pipe, the feeding pipe is vertically arranged on the outer wall of the frame, the upper part of the feeding pipe is connected to the upper separation chamber, and the lower part of the feeding pipe is connected to the lower separation chamber.

[0007] Preferably, the upper separation mechanism includes an upper screen and a second casing. The upper screen is in a horizontal "Z" shape. Second top plates are provided at both ends of the upper screen. A second feed inlet is formed in one of the second top plates, and a second iron plate is installed on the other second top plate. Both of the second top plates are rotatably provided on the inner wall of the upper separation chamber; The second casing is installed on the outer wall of the frame. A second electromagnetic plate is connected in the second casing through a first ceramic bearing. The outside of the second casing is connected with a fourth motor through a first mounting plate. The output end of the fourth motor penetrates through the second casing and is connected to one side of the second electromagnetic plate through a rubber shaft. The second electromagnetic plate, the second iron plate and the second top plate have the same diameter, and the cylindrical center lines of the second electromagnetic plate and the second iron plate are on the same straight line.

[0008] Preferably, one of the second top plates is rotatably connected to one side of the upper end of the feed pipe. The second feed inlet is communicated with the upper part of the feed pipe. A finished product tank is arranged at the lower part in the upper separation chamber, and the finished product tank is arranged directly below the upper screen.

[0009] Preferably, the lower separation mechanism includes a lower screen and a first casing. First top plates are installed at both ends of the lower screen. A first feed inlet is formed in one of the first top plates, and a first iron plate is installed on the other first top plate. Both of the first top plates are rotatably provided on the inner wall of the lower separation chamber; A first electromagnetic plate is rotatably connected in the first casing through a second ceramic bearing. The outside of the first casing is connected with a third motor through a second mounting plate. The output end of the third motor penetrates through the first casing and is fixed to one side of the first electromagnetic plate through a rubber shaft.

[0010] Preferably, the first electromagnetic plate, the first iron plate and the first top plate have the same diameter, and the center lines of the first electromagnetic plate, the first iron plate and the first top plate are on the same straight line. A feeding port is installed on the outer wall of the frame, and the lower part of the feeding port is rotatably connected to the first top plate through a sealing rubber, and the feeding port is communicated with the first feed inlet.

[0011] Preferably, the lower screen and the upper screen are perpendicular to each other, and the screen holes of the upper screen are smaller than those of the lower screen.

[0012] Preferably, a feeding trough with both sides inclined and a semi-circular bottom is arranged at the lower part in the lower separation chamber.

[0013] Preferably, the transfer mechanism includes a first auger and a second auger. The first auger is rotatably connected in the feeding trough. One end of the first auger penetrates through the side wall of the lower separation chamber and is fixedly connected to a first motor. The first motor is fixedly connected to the outer wall of the frame. One end of the feeding trough away from the first motor is communicated with the bottom of the feeding pipe. The second auger is rotatably connected in the feeding pipe. The top end of the second auger penetrates through the feeding pipe and is fixedly connected to a second motor. The second motor is installed on the top of the feeding pipe.

[0014] Preferably, a cleaning brush is arranged on the inner side of one end of the feeding port close to the lower screen. The bristles of the cleaning brush are parallel to the inner wall of the lower screen.

[0015] Preferably, a process for purifying a peramivir intermediate and separating impurities includes the following steps: Step 1: Primary purification: The peramivir intermediate after washing and drying is fed into the lower screen from the feeding port. The third motor rotates the first electromagnetic plate. The first electromagnetic plate magnetically adsorbs the first iron plate, so that the first top plate drives the lower screen to rotate. The cleaning brush brushes the lower screen to prevent blockage of the mesh holes. The lower screen filters and purifies the peramivir intermediate for the first time. The peramivir intermediate filtered out from the lower screen falls into the feeding trough. The first motor drives the first auger to send the peramivir intermediate into the feeding pipe. At this time, the second motor sends the peramivir intermediate from the feeding pipe to the second feeding port through the second auger and into the upper screen; Step 2: Secondary purification: The fourth motor magnetically drives the second iron plate through the second electromagnetic plate. The second iron plate drives the upper screen to rotate through the second top plate. The peramivir intermediate falls and impacts the upper screen in the "Z"-shaped upper screen, preventing blockage of the upper screen and accelerating the screening amount. The screened peramivir intermediate is taken out from the finished product trough.

[0016] The present invention provides a device and a process for purifying a peramivir intermediate and separating impurities. The following beneficial effects are achieved: The present invention rotates the first electromagnetic plate through the third motor, and the first electromagnetic plate adsorbs the first iron plate through magnetic force to drive the first top plate to rotate the lower screen, and the cleaning brush brushes the lower screen to avoid clogging of the mesh, and the lower screen filters and purifies the impurities of the peramivir intermediate for the first time, and then the transfer mechanism transports the peramivir intermediate from the lower separation mechanism to the upper separation mechanism, and then the fourth motor drives the second iron plate through the magnetic force of the second electromagnetic plate, and the second iron plate rotates the upper screen through the second top plate, and the peramivir intermediate falls in the "Z"-shaped upper screen to impact the upper screen, so as to avoid clogging of the upper screen and accelerate the screening amount, and the screened peramivir intermediate falls into the finished product tank Taking out, the first purification and impurity removal and the second purification and impurity removal settings make the purification and impurity removal efficiency of the Peramivir intermediate higher. At the same time, the lower screen cooperates with the cleaning brush to screen the Peramivir intermediate, and the upper screen throws the Peramivir intermediate up and then drops it for screening. While ensuring the screening efficiency, no vibration mechanism is used, and a magnetic drive method is used. There will be no vibration and knocking between the machines inside the frame, so that the mechanical drive mechanism and the screening mechanism are separated, and there will be no accelerated wear between the machines. When the Peramivir intermediate is screened, no secondary mechanical debris will be added, ensuring the high purity of the purification and impurity removal of the Peramivir intermediate. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A perspective view of the present invention; Figure 2 It is the main structural diagram of the present invention; Figure 3 It is a side structural diagram of the present invention; Figure 4 is a three-dimensional diagram of the lower separation mechanism of the present invention; Figure 5 It is a three-dimensional diagram of the upper separation structure of the present invention; Figure 6 for Figure 2 The enlarged view of point A in the middle; Figure 7 for Figure 3 Enlarged view of point B in the middle.

[0018] Among them, 1. Frame; 2. Lower separation mechanism; 3. Upper separation mechanism; 4. Transfer mechanism; 5. First motor; 6. First auger; 7. Feeding trough; 8. Cleaning brush; 9. First feed inlet; 10. Lower screen; 11. Feeding pipe; 12. Finished product trough; 13. Second auger; 14. Lower separation chamber; 15. Second motor; 16. Upper screen; 17. Upper separation chamber; 18. Third motor; 19. Feeding port; 20. First housing; 21. First electromagnetic plate; 22. First iron plate; 23. First top plate; 24. Fourth motor; 25. Second housing; 26. Second electromagnetic plate; 27. Second iron plate; 28. Second top plate; 29. Second feed inlet; 30. First ceramic bearing; 31. First mounting plate; 32. Second mounting plate; 33. Second ceramic bearing. Detailed implementation mode

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0020] Embodiment 1: As Figures 1-7 shown, the embodiment of the present invention provides a purification and impurity separation device for peramivir intermediate, including a frame 1. An upper separation chamber 17 is arranged in the upper part of the frame 1, and a lower separation chamber 14 is arranged in the lower part of the frame 1. An upper separation mechanism 3 for the second purification and impurity separation of peramivir intermediate is arranged in the upper separation chamber 17, and a lower separation mechanism 2 for the first purification and impurity separation of peramivir intermediate is arranged in the lower separation chamber 14. A transfer mechanism 4 for transporting the peramivir intermediate from the lower separation mechanism 2 to the upper separation mechanism 3 is arranged on one side of the frame 1. The lower separation mechanism 3 performs primary purification and impurity removal on the peramivir intermediate, and then transports the peramivir intermediate to the upper separation mechanism 2 through the transfer mechanism 4 for secondary impurity removal and purification. The settings of primary purification and impurity removal and secondary purification and impurity removal make the purification and impurity removal efficiency of the peramivir intermediate higher. At the same time, the lower screen 10 cooperates with the cleaning brush 8 to screen the peramivir intermediate, and the upper screen 16 screens the peramivir intermediate by throwing it up and then letting it fall. While ensuring the screening efficiency, without using a vibration mechanism, a magnetic drive method is adopted. There will be no vibration knocking between the machines inside the frame 1, separating the mechanical drive mechanism and the screening mechanism, and there will be no accelerated wear between the machines, so that when screening the peramivir intermediate, no secondary mechanical debris will be added, ensuring a high purity of the purification and impurity removal of the peramivir intermediate; The setting of separating internal screening and external drive results in less wear and vibration between machines. Mechanical wear will not contaminate the peramivir intermediate, enabling better purification and impurity removal efficiency without causing secondary pollution to the peramivir intermediate. The transfer mechanism 4 includes a feeding pipe 11. The feeding pipe 11 is vertically arranged on the outer wall of the frame 1. The upper part of the feeding pipe 11 is connected to an upper separation chamber 17, and the lower part of the feeding pipe 11 is connected to a lower separation chamber 14. The feeding pipe 11 can transport the peramivir intermediate from the lower separation chamber 14 to the upper separation chamber 17.

[0021] The upper separation mechanism 3 includes an upper screen 16 and a second housing 25. The upper screen 16 is in a horizontal "Z" - shaped configuration. Both ends of the upper screen 16 are provided with second top plates 28. A second feed inlet 29 is opened on one side of the second top plate 28, and a second iron plate 27 is installed on the other side of the second top plate 28. Both second top plates 28 are rotatably arranged on the inner wall of the upper separation chamber 17. The rotation of the second top plate 28 drives the rotation of the second iron plate 27, making it convenient for the second iron plate 27 to be driven to rotate by the second electromagnetic plate 26. The "Z" - shaped setting enables the peramivir intermediate to not roll but only fall when being screened on the upper screen 16. Therefore, it can achieve accelerated screening through its own impact. The second housing 25 is installed on the outer wall of the frame 1. Inside the second housing 25, a second electromagnetic plate 26 is connected through a first ceramic bearing 30. Outside the second housing 25, a fourth motor 24 is connected through a first mounting plate 31. The output end of the fourth motor 24 passes through the second housing 25 and is connected to one side of the second electromagnetic plate 26 through a rubber shaft. The rubber shaft prevents the magnetic force of the second electromagnetic plate 26 from affecting the operation of the fourth motor 24. The diameters of the second electromagnetic plate 26, the second iron plate 27, and the second top plate 28 are the same. The cylindrical centerlines of the second electromagnetic plate 26 and the second iron plate 27 are on the same straight line. The setting of the same straight line and the same center makes it better driven and magnetically adsorbed, enabling the equipment to operate more sensitively with a high driving force.

[0022] One side of the second top plate 28 is rotatably connected to one side of the upper end of the feeding pipe 11. The second feed inlet 29 is communicated with the upper part of the feeding pipe 11. A finished product tank 12 is arranged at the lower part inside the upper separation chamber 17. The finished product tank 12 is arranged directly below the upper screen 16 and is arranged inside the frame 1 and can be drawn out, facilitating the extraction of the collected peramivir intermediate.

[0023] The lower separation mechanism 2 includes a lower screen 10 and a first housing 20. Both ends of the lower screen 10 are provided with first top plates 23. A first feed inlet 9 is opened on one side of the first top plate 23, and a first iron plate 22 is installed on the other side of the first top plate 23. Both first top plates 23 are rotatably arranged on the inner wall of the lower separation chamber 14. The driving methods of the first top plate 23 and the first iron plate 22 of the lower separation mechanism 2 are the same as those of the upper separation mechanism 3. Inside the first casing 20, a first electromagnetic plate 21 is rotatably connected through a second ceramic bearing 33. The first ceramic bearing 30 and the second ceramic bearing 33 are used to avoid the influence of magnetic attraction on its rotation. Outside the first casing 20, a third motor 18 is connected through a second mounting plate 32. The output end of the third motor 18 passes through the first casing 20 and is fixed to one side of the first electromagnetic plate 21 through a rubber shaft. The driving modes of the first electromagnetic plate 21 and the first iron plate 22 are the same.

[0024] The diameters of the first electromagnetic plate 21, the first iron plate 22, and the first top plate 23 are all the same, and the center lines of the first electromagnetic plate 21, the first iron plate 22, and the first top plate 23 are all on the same straight line. A feeding port 19 is installed on the outer wall of the frame 1. The lower part of the feeding port 19 and the first top plate 23 are rotatably connected through a sealing rubber. The feeding port 19 is communicated with the first feeding port 9. By rotating relatively, it is possible to avoid movement interference between the feeding port 19 and the lower sieve 10.

[0025] The lower sieve 10 and the upper sieve 16 are perpendicular to each other. The sieve holes of the upper sieve 16 are smaller than those of the lower sieve 10. The setting of secondary purification and impurity removal is to adopt the method of gradually reducing the screening small holes, so as to better improve the purity of the peramivir intermediate. The perpendicular setting here makes it convenient to screen and process the intermediate.

[0026] Inside the lower separation chamber 14, a feeding trough 7 with both sides inclined and a semi-circular bottom is arranged at the lower part. The feeding trough 7 is used to collect the screened peramivir intermediate so that it can be conveyed to the bottom of the feeding pipe 11 by the first auger 6.

[0027] The transfer mechanism 4 includes a first auger 6 and a second auger 13. The first auger 6 is rotatably connected in the feeding trough 7. One end of the first auger 6 passes through the side wall of the lower separation chamber 14 and is fixedly connected to a first motor 5. The first motor 5 is fixedly connected to the outer wall of the frame 1. One end of the feeding trough 7 away from the first motor 5 is communicated with the bottom of the feeding pipe 11. The second auger 13 is rotatably connected in the feeding pipe 11. The top end of the second auger 13 passes through the feeding pipe 11 and is fixedly connected to a second motor 15. The second motor 15 is installed on the top of the feeding pipe 11. The peramivir intermediate in the feeding trough 7 falls from the inclined surface to the bottom. The first motor 5 makes the peramivir intermediate enter the bottom of the feeding pipe 11 from the feeding trough 7 through the first auger 6. Then, the second motor 15 realizes the lifting of the peramivir intermediate to the second feeding port 29 through the second auger 13 and then enters the upper sieve 16 for screening.

[0028] A cleaning brush 8 is arranged inside one end of the feeding port 19 close to the lower sieve 10. The bristled side of the cleaning brush 8 is parallel to the inner wall of the lower sieve 10. The cleaning brush 8 accelerates the screening speed of the lower sieve 10 and prevents it from being blocked by the mesh holes.

[0029] Embodiment 2: Refer to Figures 1-7 As shown, a process for purifying a peramivir intermediate and separating impurities. The equipment used in the process for purifying a peramivir intermediate and separating impurities is the equipment described above. The process includes the following steps: Step 1: Primary purification: The washed and dried peramivir intermediate is fed into the lower sieve 10 from the feeding port 19. The third motor 18 rotates the first electromagnetic plate 21. The first electromagnetic plate 21 magnetically adsorbs the first iron plate 22, causing the first top plate 23 to drive the lower sieve 10 to rotate. The cleaning brush 8 brushes the lower sieve 10 to prevent blockage of the mesh holes. The lower sieve 10 filters and purifies the peramivir intermediate for the first time. The peramivir intermediate filtered out from the lower sieve 10 falls into the feeding trough 7. The first motor 5 drives the first auger 6 to send the peramivir intermediate into the feeding pipe 11. At this time, the second motor 15 drives the peramivir intermediate from the feeding pipe 11 to the second feeding port 29 through the second auger 13 and into the upper sieve 16. The primary purification removes large impurities; Step 2: Secondary purification: The fourth motor 24 magnetically drives the second iron plate 27 through the second electromagnetic plate 26. The second iron plate 27 causes the upper sieve 16 to rotate through the second top plate 28. The peramivir intermediate falls and impacts the upper sieve 16 in the "Z"-shaped upper sieve 16, preventing blockage of the upper sieve 16 and accelerating the screening amount. The screened peramivir intermediate is taken out from the finished product trough 12.

[0030] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A purification and impurity separation device for a peramivir intermediate, comprising a frame (1), characterized in that: An upper separation chamber (17) is disposed at the upper portion of the frame (1), a lower separation chamber (14) is disposed at the lower portion of the frame (1), an upper separation mechanism (3) for the second purification of the peramivir intermediate and the separation of impurities is disposed in the upper separation chamber (17), a lower separation mechanism (2) for the first purification of the peramivir intermediate and the separation of impurities is disposed in the lower separation chamber (14), and a transport mechanism (4) for transporting the peramivir intermediate from the lower separation mechanism (2) to the upper separation mechanism (3) is disposed on one side of the frame (1); The transfer mechanism (4) comprises a feeding pipe (11), wherein the feeding pipe (11) is vertically arranged on the outer wall of the frame (1), the upper part of the feeding pipe (11) is connected to an upper separation chamber (17), and the lower part of the feeding pipe (11) is connected to a lower separation chamber (14).

2. The purification and impurity separation equipment of a peramivir intermediate according to claim 1, characterized in that: The upper separation mechanism (3) comprises an upper screen (16) and a second housing (25); the upper screen (16) is in a transverse "Z" shape; both ends of the upper screen (16) are provided with second top plates (28); a second feed port (29) is provided on one side of the second top plate (28); a second iron plate (27) is installed on the other side of the second top plate (28); and the two second top plates (28) are rotatably arranged on the inner wall of the upper separation chamber (17); The second housing (25) is mounted on the outer wall of the frame (1); a second electromagnetic plate (26) is connected to the inside of the second housing (25) via a first ceramic bearing (30); a fourth motor (24) is connected to the outside of the second housing (25) via a first mounting plate (31); an output end of the fourth motor (24) passes through the second housing (25) and is connected to one side of the second electromagnetic plate (26) via a rubber shaft; the diameters of the second electromagnetic plate (26), the second iron plate (27) and the second top plate (28) are the same; and the cylindrical center lines of the second electromagnetic plate (26) and the second iron plate (27) are on the same straight line.

3. The purification and impurity separation equipment of a peramivir intermediate according to claim 2, characterized in that: The second top plate (28) is rotatably connected to one side of the upper end of the feed pipe (11), the second feed port (29) is communicated with the upper portion of the feed pipe (11), and a finished product trough (12) is provided in the lower portion of the upper separation chamber (17), and the finished product trough (12) is provided directly below the upper screen (16).

4. The purification and impurity separation equipment of a peramivir intermediate according to claim 1, characterized in that: The lower separation mechanism (2) comprises a lower screen (10) and a first housing (20), first top plates (23) being installed at both ends of the lower screen (10), a first feed port (9) being provided on one side of the first top plate (23), and a first iron plate (22) being installed on the other side of the first top plate (23), and the two first top plates (23) being rotatably arranged on the inner wall of the lower separation chamber (14); A first electromagnetic plate (21) is rotatably connected inside the first housing (20) via a second ceramic bearing (33), and a third motor (18) is connected outside the first housing (20) via a second mounting plate (32); an output end of the third motor (18) passes through the first housing (20) and is fixed to one side of the first electromagnetic plate (21) via a rubber shaft.

5. The purification and impurity separation equipment of a peramivir intermediate according to claim 4, characterized in that: The diameters of the first electromagnetic plate (21), the first iron plate (22) and the first top plate (23) are all the same; the center lines of the first electromagnetic plate (21), the first iron plate (22) and the first top plate (23) are all on the same straight line; a feeding port (19) is installed on the outer wall of the frame (1); the lower part of the feeding port (19) and the first top plate (23) are rotatably connected via a sealing rubber; and the feeding port (19) and the first feed port (9) are connected.

6. The purification and impurity separation equipment of a peramivir intermediate according to claim 4, characterized in that: The lower screen (10) and the upper screen (16) are perpendicular to each other, and the drying mesh holes of the upper screen (16) are smaller than the mesh holes of the lower screen (10).

7. The purification and impurity separation equipment of a peramivir intermediate according to claim 4, characterized in that: A feeding trough (7) with inclined sides and a semicircular bottom is provided in the lower part of the lower separation chamber (14).

8. The purification and impurity separation equipment of a peramivir intermediate according to claim 7, characterized in that: The transfer mechanism (4) comprises a first auger (6) and a second auger (13), wherein the first auger (6) is rotatably connected in the feed trough (7), one end of the first auger (6) penetrates the side wall of the lower separation chamber (14) and is fixedly connected to the first motor (5), the first motor (5) is fixedly connected to the outer wall of the frame (1), the end of the feed trough (7) away from the first motor (5) is connected to the bottom of the feed pipe (11), the second auger (13) is rotatably connected in the feed pipe (11), the top end of the second auger (13) penetrates the feed pipe (11) and is fixedly connected to the second motor (15), and the second motor (15) is installed on the top of the feed pipe (11).

9. The purification and impurity separation equipment of a peramivir intermediate according to claim 5, characterized in that: A cleaning brush (8) is provided on the inner side of one end of the feeding port (19) close to the lower screen (10), and the bristle side of the cleaning brush (8) is parallel to the inner wall of the lower screen (10).

10. A process for purifying a peramivir intermediate and separating impurities, wherein the equipment used in the process for purifying a peramivir intermediate and separating impurities is the equipment described in claims 1-9, characterized in that: The following steps are involved: Step 1, primary purification: the washed and dried peramivir intermediate is fed into the lower screen (10) from the feeding port (19), the third motor (18) rotates the first electromagnetic plate (21), the first electromagnetic plate (21) magnetically adsorbs the first iron plate (22) to cause the first top plate (23) to drive the lower screen (10) to rotate, the cleaning brush (8) brushes the lower screen (10) to avoid clogging the mesh, the lower screen (10) filters and purifies the peramivir intermediate for the first time, the peramivir intermediate filtered out from the lower screen (10) falls into the feeding trough (7), the first motor (5) drives the first auger (6) to feed the peramivir intermediate into the feeding pipe (11), at this time, the second motor (15) lifts the peramivir intermediate from the feeding pipe (11) to the second feeding port (29) through the second auger (13) to enter the upper screen (16); Step 2, secondary purification: the fourth motor (24) drives the second iron plate (27) through the second electromagnetic plate (26), and the second iron plate (27) rotates the upper screen (16) through the second top plate (28), and the peramivir intermediate falls in the "Z"-shaped upper screen (16) and impacts the upper screen (16), thereby preventing the upper screen (16) from being blocked and accelerating the screening amount, and the screened peramivir intermediate falls into the finished product tank (12) and is taken out.

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