Acupuncture point ironing moxibustion patch combined with compound clove appetizing patch for treating children's dwarf disease

Abstract

The invention relates to the technical field of external treatment of traditional Chinese medicine, and discloses an acupoint ironing moxibustion patch for treating children's dwarf disease in combination with a compound clove appetizing patch, the acupoint ironing moxibustion patch comprises: a non-woven fabric layer, which is used for providing a supporting effect and preventing the non-woven fabric layer from generating a hook line with clothes during use; the automatic heat production layer is arranged above the non-woven fabric layer and is used for providing a temperature rising capability; the medicine is arranged above the automatic heat production layer, ironing moxibustion is formed on the basis of heat energy generated by the automatic heat production layer, and the medicine is absorbed by a user when making contact with the skin of the Shenque acupoint and the body'zhu 'acupoint of the patient. Through cooperation of medicines and the automatic heat production layer, transdermal absorption of medicine components can be promoted, effects are achieved by stimulating acupuncture points, the heating temperature is controlled through the automatic heat production layer to conduct ironing moxibustion on the Shenque acupoint, the body'zhu 'acupoint and the like, the appetite, sleep and serum insulin-like growth factor-I of a patient are improved, and normal growth of the patient is recovered.

Description

Technical Field

[0001] The present invention relates to the technical field of external treatment of traditional Chinese medicine, and particularly to an acupoint ironing moxibustion patch for treating children with short stature in combination with compound clove appetizer patch. Background Art

[0002] Short stature is a relatively common growth and development disorder in children. Its etiology is complex. Since the child is significantly shorter than peers of the same age, it is likely to cause negative psychological problems such as anxiety, fear, and inferiority in the child, which has an important impact on the child's health; it will also have varying degrees of impact on current life, study, as well as future work and spouse selection; the height of children with short stature is -2SD shorter than that of children of the same age, and the growth rate is slow. Although there is no record of the disease name of short stature in ancient Chinese medical books, according to its clinical manifestations, it can be classified into the category of "five delays and five flaccidities". The etiology is mostly due to insufficient essence of the parents at birth and improper nursing in the later stage, resulting in insufficient spleen and kidney qi and blood. The disease location is mainly in the spleen and kidney, and the nature of the disease is mostly deficiency syndrome. Because the kidney stores essence and is the "foundation of congenital nature and the source of life", it is closely related to human growth, development, and reproduction. If the kidney essence is deficient, the bone marrow will be insufficiently filled, and the growth and development of bones will become slow; the spleen is in charge of transportation and transformation, with the physiological function of turning food into qi and blood essence and transporting the qi and blood essence throughout the body to nourish the zang-fu organs, meridians, limbs, bones, muscles, and skin. Therefore, human growth and development are also closely related to the spleen. If the spleen is weak, the transportation and transformation will be abnormal, food cannot be normally transformed into essence substances, resulting in insufficient qi and blood production, and the qi and blood essence cannot be transported throughout the body, and the zang-fu organs, meridians, bones, and muscles will lose moistening and nourishment, thus presenting symptoms such as less rosy complexion, poor sleep, emaciation, and short stature.

[0003] Currently, for the treatment of children with short stature, modern medicine mainly takes corresponding intervention measures according to their specific etiology. For children with short stature with clear etiology, such as growth hormone deficiency, hypothyroidism, chromosomal abnormalities, etc., Western medicine generally uses targeted treatment means for intervention, and the curative effect is relatively clear. However, for idiopathic short stature (ISS) with unknown etiology, recombinant human growth hormone (rhGH) is mostly used for treatment clinically, and this therapy can improve the growth rate and final height of children to a certain extent.

[0004] However, there are still some deficiencies in the treatment of children with short stature in the existing technology. Firstly, although modern medical treatment has obvious curative effects in some patients with clear etiologies, its treatment methods mainly rely on drugs such as growth hormone, which have problems of strong dependence, high cost, long treatment courses, side effect risks, and poor compliance. Especially in children with idiopathic short stature, a group lacking a clear pathogenic mechanism, although modern medicine provides a standardized treatment path, such as growth hormone replacement therapy, in clinical practice, some children have poor responses to treatment and limited improvement in expected height. In addition, the current treatment plan mainly focuses on hormone level intervention, and rarely combines factors such as the physical state, lifestyle, and functional development characteristics of children. The individualized intervention means are not sufficient, which to a certain extent affects the overall treatment effect. Summary of the Invention

[0005] In view of the deficiencies of the existing technology, the present invention provides an acupoint ironing moxibustion patch for treating children with short stature in combination with Compound Eugenia Fruit Stomach-Activating Patch, which solves the problems of lack of individualized regulation, insufficient overall conditioning, and poor curative effect stability in the existing treatment of short stature.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: An acupoint ironing moxibustion patch for treating children with short stature in combination with Compound Eugenia Fruit Stomach-Activating Patch, the acupoint ironing moxibustion patch includes:

[0007] Non-woven fabric layer: used to provide a supporting effect, and at the same time, prevent snagging with clothes during use;

[0008] Automatic heat generation layer: which is arranged above the non-woven fabric layer and is used to provide the ability to increase temperature;

[0009] Drug: which is arranged above the automatic heat generation layer, and forms ironing moxibustion based on the heat energy generated by the automatic heat generation layer, so that the drug is absorbed by the user when it contacts the skin of the umbilicus and the body column acupoints of the patient.

[0010] Preferably, the acupoint ironing moxibustion patch further includes:

[0011] Adhesive layer, which is arranged on the upper side of the automatic heat generation layer and is used to support the drug, so that the drug remains in contact with the automatic heat generation layer and forms ironing moxibustion under the heat energy generated by the automatic heat generation layer;

[0012] Anti-sticking layer, which is arranged above the drug and is used to prevent adhesion when the adhesive layer contacts external objects, and the anti-sticking layer is adhered to both ends of the non-woven fabric layer, so that the acupoint ironing moxibustion patch can be stored.

[0013] Preferably, adhesives are arranged above both the non-woven fabric layer and the automatic heat generation layer, and the non-woven fabric layer, the automatic heat generation layer, and the adhesive layer are adhesively fixed in sequence from bottom to top.

[0014] Preferably, an anhydrous adhesive is provided on the inner wall of the adhesive layer, and the drug is fixedly connected to the inner wall of the adhesive layer through the anhydrous adhesive.

[0015] Preferably, the drug is a compound clove appetizer pill, and the compound clove appetizer pill comprises the following components in parts by weight:

[0016] Clove: 5 - 10 parts; Atractylodes lancea: 10 - 20 parts; Atractylodes macrocephala and cardamom: 8 - 15 parts; Amomum villosum: 5 - 10 parts; Aucklandia lappa: 3 - 8 parts; Licorice: 5 - 10 parts; Fructus aurantii: 8 - 15 parts; Astragalus membranaceus: 15 - 25 parts; Dioscorea opposita: 20 - 30 parts.

[0017] Preferably, an adhesive is provided on the top of the adhesive layer for attaching the acupoint moxibustion ironing patch to the skin of a patient and keeping it from falling off.

[0018] Preferably, an anti - sticking adhesive is provided on the side of the anti - sticking layer close to the drug, and both sides of the bottom of the anti - sticking layer are adhered to the non - woven fabric layer.

[0019] Preferably, the automatic heat - generating layer comprises the following components in parts by weight:

[0020] Iron powder: 60 - 75 parts; Carbon powder: 5 - 10 parts; Wood powder: 5 - 10 parts; Sodium chloride: 1 - 3 parts; Water: 10 - 15 parts; Gelatin solution: with a concentration of 10 - 15%, for outer coating.

[0021] The present invention provides an acupoint moxibustion ironing patch combined with a compound clove appetizer pill for treating pediatric short stature. It has the following beneficial effects:

[0022] 1. The present invention innovatively introduces an automatic heat - generating structure to form a constant - heating application system, controlling the temperature range between 40 - 55 °C to form moxibustion ironing, and is paired with a compound clove appetizer pill to effectively stimulate the drug penetration activity and enhance the intensity of acupoint warming stimulation, achieving the effect of treating short stature.

[0023] 2. The present invention uses an anhydrous adhesive surface to fix the pill in the adhesive structure, and through the close fitting of the adhesive layer and the automatic heat - generating layer, ensures that the drug is always in an effective transdermal state under the action of heat, maintaining an efficient absorption path. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 is the structural diagram of the present invention;

[0025] Figure 2 is the structural schematic diagram of the drug of the present invention;

[0026] Figure 3 is the structural schematic diagram of the non - woven fabric layer of the present invention;

[0027] Figure 4This is a schematic structural diagram of the automatic heat generation layer of the present invention.

[0028] Among them, 1. Anti-sticking layer; 2. Drug; 3. Adhesive layer; 4. Automatic heat generation layer; 5. Non-woven fabric layer. Detailed implementation manners

[0029] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the specification of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0030] Please refer to the attached Figure 1 - attached Figure 4 , the embodiments of the present invention provide an acupoint ironing moxibustion patch for treating children's short stature in combination with compound clove appetizer patch. The acupoint ironing moxibustion patch includes:

[0031] Non-woven fabric layer 5: It is used to provide a supporting role. At the same time, it prevents snagging with clothes during use. The non-woven fabric layer 5 is the bottom layer structure of the acupoint ironing moxibustion patch and is made of a medical non-woven fabric material with good flexibility, excellent air permeability, and strong anti-stretching ability. Its main function is to carry the entire patch structure and prevent the patch from shifting and wrinkling due to the patient's activities during use, ensuring that the acupoint correspondence relationship does not deviate; in addition, the surface fibers of the non-woven fabric layer 5 are densely arranged, effectively preventing snagging during the process of putting on and taking off clothes, and improving the use safety and comfort;

[0032] Automatic heat generation layer 4: It is arranged above the non-woven fabric layer 5 and is used to provide the ability to increase temperature. When the ironing moxibustion patch is opened and exposed to the air, the automatic heat generation layer 4 immediately starts a self-heating reaction, releases stable heat energy, and maintains a temperature suitable for human ironing moxibustion: 40°C - 55°C, and maintains ironing moxibustion for > 6 hours; the heat effect conduction direction is mainly upward, and it is transmitted to the upper part through short-distance heat radiation, promoting the activation of the drug 2 component and permeating into the deep layer of the acupoint along with the skin microcirculation, effectively improving the penetration and action efficiency of traditional Chinese medicine treatment;

[0033] Drug 2: It is arranged above the automatic heat generation layer 4, and forms ironing moxibustion based on the heat energy generated by the automatic heat generation layer 4, so that the drug 2 is absorbed by the user when it contacts the skin of the patient's Shenque acupoint and Shenzhu acupoint. During use, by attaching part of the drug 2 to the skin of the patient's acupoint, and the heat effect conduction of the automatic heat generation layer 4 promotes the activation of the drug 2 component and permeates into the deep layer of the acupoint along with the skin microcirculation, effectively improving the penetration and action efficiency of traditional Chinese medicine treatment.

[0034] Please refer to the attached Figure 1 - attached Figure 4, in a preferred embodiment of the present invention, the acupoint moxibustion patch further comprises:

[0035] The adhesive layer 3 is disposed on the upper side of the automatic heat generation layer 4 and is used to support the drug 2, so that the drug 2 remains in contact with the automatic heat generation layer 4 and forms moxibustion by the heat energy generated by the automatic heat generation layer 4. Through the support of the drug 2 by the adhesive layer 3, it can be ensured that the drug 2 remains in contact with the automatic heat generation layer 4 during use, so that through the transfer of heat energy, the drug 2 can be effectively permeated and absorbed when contacting the skin;

[0036] The anti-sticking layer 1 is disposed above the drug 2 and is used to prevent the adhesive layer 3 from sticking when contacting an external object. Moreover, the anti-sticking layer 1 is adhered to both ends of the non-woven fabric layer 5, so that the acupoint moxibustion patch can be stored. The setting of the anti-sticking layer 1 prevents the adhesive layer 3 and the drug 2 from sticking when contacting an external object or other articles, and at the same time prevents the operation of the automatic heat generation layer 4, keeps the moxibustion patch clean and avoids causing secondary pollution or adhesive residue during use. In addition, it can maintain the adhesiveness of the adhesive layer 3, so that the acupoint moxibustion patch maintains adhesiveness during use.

[0037] Please refer to the attached Figure 1 - attached Figure 4 , in a preferred embodiment of the present invention, adhesives are provided above both the non-woven fabric layer 5 and the automatic heat generation layer 4. The non-woven fabric layer 5, the automatic heat generation layer 4 and the adhesive layer 3 are adhesively fixed in sequence from bottom to top. Through the provided adhesives, the automatic heat generation layer 4 can be fixed above the non-woven fabric layer 5, and at the same time the adhesive layer 3 can be fixed above the automatic heat generation layer 4, thereby forming the framework of the acupoint moxibustion patch, and it can be used after the drug 2 is put in.

[0038] Please refer to the attached Figure 1 - attached Figure 4 , in a preferred embodiment of the present invention, anhydrous glue is provided on the inner wall of the adhesive layer 3, and the drug 2 is fixedly connected to the inner wall of the adhesive layer 3 through the anhydrous glue. Through the provided anhydrous glue, it can play a role in fixing the drug 2 when the drug 2 enters the adhesive layer 3 and prevent the drug 2 from falling off.

[0039] Please refer to the attached Figure 1 - attached Figure 4 , in a preferred embodiment of the present invention, the drug 2 is a compound clove appetizer pill, and the compound clove appetizer pill comprises the following components in parts by weight:

[0040] Clove: 5 - 10 parts; Atractylodes lancea: 10 - 20 parts; Atractylodes macrocephala and cardamom: 8 - 15 parts; Amomum villosum: 5 - 10 parts; Aucklandia lappa: 3 - 8 parts; Licorice: 5 - 10 parts; Fructus aurantii: 8 - 15 parts; Astragalus membranaceus: 15 - 25 parts; Chinese yam: 20 - 30 parts;

[0041] Preparation method of the compound clove appetizer pill:

[0042] 1. Select medicinal materials

[0043] Place all medicinal materials on the selection table respectively, select, remove gravel and impurities, sieve out dust, and pack them in containers respectively, making material marks.

[0044] 2. Wash medicinal materials:

[0045] Place all medicinal materials in the medicinal material washing machine for washing in turn. Wash to remove dust and mildew, ensuring no residual sediment and impurities. After washing, cut them into thick slices of 2 - 4 mm, and finally break them.

[0046] 3. Dry:

[0047] Place the medicinal material clove in a normal temperature drying room for drying (when the moisture content of the medicinal material entering the warehouse is close to 12%). After 24 hours, the moisture content ≤ 8.0%. Pack it in a container with an inner plastic film bag, seal it, make a mark, and send it to the clean material temporary storage room.

[0048] 4. Extract and concentrate:

[0049] Put the medicinal materials atractylodes rhizome, atractylodes macrocephala rhizome, amomum kravanh, amomum villosum, costus root into the feeding port. When feeding, generally put the amomum kravanh and amomum villosum, which are not easy to boil and rot, first, and put the atractylodes rhizome, atractylodes macrocephala rhizome, and costus root on top to facilitate the outflow of the medicinal liquid. After the medicinal materials are put in, close the feeding port door. Add the medicinal material wetting liquid into the tank, open the water valve to add water into the tank, and the total water volume is 3 times the total amount of the medicinal materials. The steam gauge pressure shall not be greater than 0.25 Mpa. When boiling bubbles appear on the contact surface between the medicinal materials and the tank wall, adjust the steam valve so that the steam pressure is about 0.05 MPa. When there is more oil layer in the separator, open the oil collection valve to collect the volatile oil into the oil collector. The distillation process takes about 17 hours and the distillation ends. Then add 1.5 times the total amount of the medicinal materials in water, and keep boiling for 60 minutes for the distillation operation. Pump the extracted medicinal liquid from the large storage tank to the storage tank and let it stand for more than 2 hours. Start the vacuum pump. When the vacuum degree reaches 0.06 MPa, slowly open the steam valve to heat up. Adjust the steam valve (pressure ≤ 0.15 MPa) so that the boiling foam in the evaporator does not exceed the upper sight glass. During the concentration process, often supplement a small amount of medicinal liquid to control the liquid level at half of the concentration tank. Until all the medicinal liquid is pumped into the concentration tank, the vacuum degree of the concentration tank can vary in the range of - 0.05 to - 0.08 MPa, and the evaporation chamber temperature is in the range of 60℃ - 70℃. Start the stirring paddle to stir, and control the normal pressure concentration time to be not less than 30 minutes. When the normal pressure concentration is about to reach the paste collection position, collect the paste from the paste outlet at the lower part of the concentrator.

[0050] 5. Grind and sieve:

[0051] The dried medicinal materials (cloves) are crushed in an ultrafine pulverizer or a high-efficiency sifting machine. The circulating water temperature of the pulverizer's chiller is 5 - 15°C, and the pulverizing time is 12 minutes. The particle size of the pulverized powder should be controlled such that the mesh number of the sieve is not less than 80 - 100 meshes, ensuring that the medicinal powder is delicate, uniform, and convenient for mixing and forming.

[0052] 6. Formulation mixing:

[0053] Weigh the clove medicinal powder, volatile oil, and mixed paste according to the aforementioned ratio, and pour them into a trough mixer or a three-dimensional mixer in sequence for stirring and mixing. Set the mixing time at 20 - 30 minutes, and maintain the stirring speed at 15 - 30 revolutions per minute. The mixing process must be uniform to ensure that each pill contains the same proportion of ingredients, and finally obtain a thick paste.

[0054] 7. Medicinal material refining

[0055] Place the thick paste in the hopper of the medicinal material refining machine, start the refining machine, and refine the paste once to obtain the refined paste, ensuring that the refining can promote the fusion of ingredients and produce a synergistic effect.

[0056] 8. Pill forming:

[0057] Place the paste in the tray of the pill-making machine. Pass the made medicinal strip through under the speed reduction controller, then place it on the strip feeding wheel, and enter the pill-making cutter wheel through the strip aligner for pill making; select the strip aligner, and by adjusting the frequency of the strip aligner and the strip feeding frequency, make the pill weight between 1.20 - 1.30 g; directly load the qualified pills obtained into a stainless steel tray and cover it tightly.

[0058] 9. Packaging and storage:

[0059] The qualified pills are separately packed into medical aluminum-plastic packaging bags or glass bottles, sealed, and stored in a dry and cool place where the temperature does not exceed 20°C and the relative humidity is 35 - 75%, avoiding high temperature, humidity, and sunlight.

[0060] Please refer to the appendix Figure 1 - appendix Figure 4 , in a preferred embodiment of the present invention, an adhesive is provided on the top of the adhesive layer 3 for attaching the acupoint moxibustion patch to the patient's skin and keeping it from falling off. By setting the adhesive, the adhesive layer 3 can be adhered to the skin at the patient's acupoint by slightly pressing, so that there is no need for the patient to hold it manually and it can remain non-detached for a long time.

[0061] Please refer to the appendix Figure 1 - appendix Figure 4, in a preferred embodiment of the present invention, an anti-sticking glue is provided on the side of the anti-sticking layer 1 close to the drug 2. Both sides of the bottom of the anti-sticking layer 1 are adhered to the non-woven fabric layer 5. The anti-sticking glue is used to prevent the anti-sticking layer 1 from contacting and sticking to the drug 2, so as to ensure that the drug 2 is always in the middle of the sticking layer 3 after the anti-sticking layer 1 is torn off. By adhering both sides of the bottom of the anti-sticking layer 1 to the non-woven fabric layer 5, it is prevented that the anti-sticking layer 1 is always used to separate the drug 2 and the sticking layer 3 when not in use, and the drug 2 and the sticking layer 3 are prevented from contacting foreign objects.

[0062] Please refer to the attached Figure 1 - attached Figure 4 , in a preferred embodiment of the present invention, the self-heating layer 4 comprises the following components in parts by weight:

[0063] Iron powder: 60 - 75 parts; carbon powder: 5 - 10 parts; wood powder: 5 - 10 parts; sodium chloride: 1 - 3 parts; water: 10 - 15 parts; gelatin solution: with a concentration of 10 - 15%, for outer coating.

[0064] Preparation method of the self-heating layer 4:

[0065] 1. Dry powder mixing:

[0066] Pour the iron powder, carbon powder, wood powder and sodium chloride into a high-speed dry powder mixer. The mixing time is controlled within 10 - 15 minutes, and the rotation speed is set at 40 - 60 revolutions per minute to ensure that the four powders are evenly distributed. Keep a dry environment during mixing to prevent premature reaction with water.

[0067] 2. Humidification reaction pre-start:

[0068] After mixing, add water while stirring by spraying to ensure that each powder is moist but not caked. This step does not initiate a violent reaction, but only a pre-wetting activation state. After completion, the material presents a slightly agglomerated, moist and non-flowing loose granular state.

[0069] 3. Molding and filling:

[0070] Fill the humidified heat-generating material into a non-woven bag or air-permeable membrane layer with good air permeability. The filling thickness is controlled within 3 - 6 mm and spread evenly. The edges are fixed by hot pressing or bonding to ensure that the material does not overflow before use.

[0071] 4. Gelatin outer coating:

[0072] Feed the loaded and formed heating layer into the gelatin coating process. The gelatin solution needs to be pre-heated and dissolved to a concentration of 10-15%, with the temperature controlled between 45-60°C. Use dip coating or spraying to cover the outer surface of the heating layer with gelatin, forming a protective film layer with humidity control and air permeability functions. The coating thickness is 0.5-1 mm to ensure that it can isolate part of the moisture in the air and initiate the heating reaction after the anti-sticking layer is torn off.

[0073] 5. Drying and shaping:

[0074] After coating, put the prepared automatic heat generation layer into the drying oven and dry it at a temperature of 40-50°C for 4-6 hours to make the gelatin film dry and form. The completed heat generation layer is in a dry state, capable of immediate heating upon activation, and does not undergo oxidation reaction before direct contact with air.

[0075] Example 1:

[0076] It includes the following structural layers arranged in sequence from bottom to top:

[0077] Non-woven fabric layer 5: Select medical polypropylene fiber non-woven fabric with good air permeability and high softness, with a thickness of 0.25 mm and an area of 60 mm × 60 mm, used to provide stable body support and prevent clothing from snagging.

[0078] Automatic heat generation layer 4: The components in parts by weight are: 70 parts of iron powder, 8 parts of carbon powder, 8 parts of wood powder, 2 parts of sodium chloride, 12 parts of water. The outer layer is coated with 10% concentration gelatin solution, and the thickness of this layer is 3.5 mm, coated with a breathable film.

[0079] Adhesive layer 3: Medical polymer film coated with anhydrous glue, with moderate viscosity, used to fix the drug.

[0080] Drug layer 2: Embed a compound clove appetizer pill with a diameter of 8 mm. The pill formula is: 7 parts of cloves, 15 parts of atractylodes lancea, 12 parts of atractylodes macrocephala and amomum kravanh, 6 parts of amomum villosum, 5 parts of costus root, 7 parts of licorice, 12 parts of aurantii fructus immaturus, 20 parts of astragalus membranaceus, 25 parts of Chinese yam.

[0081] Anti-sticking layer 1: Double-sided anti-sticking paper to prevent premature contact.

[0082] Usage method: Apply it to the Shenque acupoint and Shenzhu acupoint every night for 10 hours, once a day, for a course of 3 months.

[0083] Example 2:

[0084] On the basis of Example 1, enhance the heat control of the automatic heat generation layer:

[0085] Add a microporous moisture-conducting structure to the automatic heat generation layer 4, and use a double-layer structure of non-woven fabric + directional moisture-exhausting film to enhance air permeability;

[0086] The ratio of the components in the exothermic reaction system is as follows: 65 parts of iron powder, 6 parts of carbon powder, 6 parts of wood powder, 2.5 parts of sodium chloride, 13 parts of water, and the concentration of gelatin is 12%;

[0087] This design improves the uniformity of heat maintenance. The actual test shows that the ironing and moxibustion temperature is stable at 43.5 - 45.5 °C, and the duration is > 8 hours.

[0088] Comparative Example 1: The preparation structure is the same as that of Example 1, but the automatic heat generation layer 4 is not set, and the rest of the structure remains unchanged.

[0089] Comparative Example 2: A commercially available single - flavor clove external application patch is used, which is directly applied to the Shenque acupoint and the Shenzhu acupoint, without a compound prescription and an automatic heat generation structure.

[0090] Comparative experiment:

[0091] Experimental purpose: To verify the difference in clinical efficacy between the acupoint ironing and moxibustion patch with an automatic heat generation structure and compound clove appetizer pills of the present invention in the treatment of children's short stature compared with the existing patch schemes.

[0092] Experimental grouping and sample setting:

[0093] A total of 176 children meeting the diagnostic criteria for short stature were included from the outpatient clinic. Aged 6 - 9 years old, they were randomly divided into 4 groups, with 44 people in each group = 44 sample numbers:

[0094]

[0095] III. Experimental steps:

[0096] 1. Application operation:

[0097] Acupoint selection: Shenque acupoint, Shenzhu acupoint;

[0098] Application time: Apply every night before going to bed and remove in the next morning, 8 - 12 hours each time;

[0099] Frequency: Once a day, one patch each time;

[0100] Course of treatment: Apply continuously for 6 months (3 months as one course of treatment, 2 consecutive courses);

[0101] 2. Lifestyle intervention (uniformly implemented for the four groups):

[0102] Sleep management: Turn off the lights at 9 pm and get up at 7 am;

[0103] Dietary guidance: Have regular three meals, less greasy food, and appropriately supplement calcium, zinc, and vitamin AD;

[0104] Exercise plan: 30 - minute vertical jumping or stretching exercise every day.

[0105] 3. Index detection:

[0106] Traditional Chinese Medicine (TCM) syndrome score: The score (food intake, sleep, complexion) was evaluated by the same group of TCM physicians before and after treatment, on a scale of 0 - 6 points.

[0107] Height measurement: Recorded uniformly using a standard height ruler with an accuracy of ±0.1 cm.

[0108] Serum IGF-I detection: 2 ml of venous blood was collected on an empty stomach in the early morning, serum was extracted by centrifugation, and detected by LC-MS / MS method.

[0109] IV. Evaluation indicators:

[0110] Item Measured Content Method Frequency Traditional Chinese Medicine Syndrome Score Food Intake, Sleep, Complexion Physician's Inquiry + Observation Before Treatment and 6 Months Later HGV Height Increase (cm) Height Ruler The Same as Above IGF-I Growth Factor (ng / ml) LC-MS / MS The Same as Above

[0111] The experimental results are shown in the following table:

[0112] Summary table of changes in TCM syndrome scores, height growth, and IGF-I before and after treatment in each group

[0113]

[0114] It can be seen from the above table that:

[0115] The experimental results show that the ironing moxibustion patch of the present invention has advantages in promoting the improvement of children's appetite, the enhancement of sleep quality, and the improvement of complexion. Through the self-heating structure, a constant temperature of 40 - 55 °C is continuously provided, which stimulates the activation, volatilization, and penetration of drug components during the application process, enhances the transdermal absorption efficiency, and effectively penetrates the lower part of the cortex where the Shenque and Shenzhu acupoints are located. The warm stimulation not only promotes capillary dilation and increases the distribution concentration of the drug effect in the local microcirculation, but also activates the skin - nerve - endocrine response pathway, thereby triggering a positive regulatory effect on overall growth and development. Compared with the patch without a heat generation structure or a single-herb drug patch, the present invention can more effectively mobilize the synergistic mechanism of acupoint conduction and drug release.

[0116] Further combined with the change data of serum insulin-like growth factor-I, it can be seen that the IGF-I levels in both experimental groups increased, which was higher than the slight changes in the two control groups. As a key physiological index for children's height growth, the increase in IGF-I indicates a good response of the endocrine system to external conditioning. Thus, it can be seen that the present invention can not only improve the compliance of children by improving subjective symptoms, but also has the ability to objectively improve the growth-promoting biochemical indexes. It is a new external treatment method of traditional Chinese medicine with low trauma, high compliance, and suitable for long-term intervention for children with idiopathic short stature.

[0117] Working principle: When in use, place the medicine 2 inside the adhesive layer 3, lift up the anti-sticking layer 1 through the middle self-adhesive paper and tear it off, and then directly stick it on the skin of the patient's Shenque acupoint and Shenzhu acupoint through the adhesive layer 3. In addition to exerting its effect through the action of the medicine 2 of the acupoint ironing and moxibustion patch on the acupoints, it also regulates the heat generation of the automatic heat generating layer 4 to perform ironing and moxibustion on the skin of the Shenque acupoint, Shenzhu acupoint and other acupoints, thereby stimulating the acupoints to treat dwarfism.

[0118] The following requirements need to be met when using it: regular meals, eating on time and in the right amount; reasonable combination of meat and vegetables, balanced nutrition, less fried and greasy food, snacks and drinks, reasonable supplement of vitamins AD, calcium, zinc and other nutrients; ensure adequate sleep, turn off the lights and go to bed at 9 o'clock every night, get up after 7 o'clock the next morning; insist on half an hour of vertical exercise every day. On this basis, acupoint application acupoint ironing and moxibustion paste, select the Shenque point and Shenzhu point, apply before going to bed at night, remove the next morning, lasting 8 to 12 hours, once a day, 3 months as a course of treatment, and observe 2 courses of treatment.

[0119] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An acupoint ironing and moxibustion patch for treating dwarfism in children combined with a compound clove appetizer patch, characterized in that: The acupoint ironing and moxibustion patch comprises: Non-woven fabric layer (5): used to provide support and prevent snagging with clothing during use; Automatic heat-generating layer (4): arranged above the non-woven fabric layer (5) to provide temperature-raising capability; Medicine (2): It is arranged above the self-heating layer (4), and forms moxibustion based on the heat energy generated by the self-heating layer (4), so that the medicine (2) is absorbed by the user when it comes into contact with the skin of the patient's Shenque point and Shenzhu point.

2. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 1, characterized in that: The acupoint ironing and moxibustion patch also includes: An adhesive layer (3) is arranged on the upper side of the self-heat generating layer (4) and is used to support the medicine (2) so that the medicine (2) remains in contact with the self-heat generating layer (4) and is subjected to the heat energy generated by the self-heat generating layer (4) to form a moxibustion effect; The anti-adhesive layer (1) is arranged above the medicine (2) and is used to prevent the adhesive layer (3) from sticking to an external object when in contact with the adhesive layer (3). The anti-adhesive layer (1) is adhered to both ends of the non-woven fabric layer (5) so that the acupoint ironing and moxibustion patch can be stored.

3. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 1, characterized in that: Viscose is provided above the non-woven fabric layer (5) and the self-heat generating layer (4), and the non-woven fabric layer (5), the self-heat generating layer (4) and the adhesive layer (3) are sequentially glued and fixed from bottom to top.

4. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 2, characterized in that: The inner wall of the adhesive layer (3) is provided with anhydrous glue, and the medicine (2) is fixedly connected to the inner wall of the adhesive layer (3) by the anhydrous glue.

5. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 4, characterized in that: The drug (2) is a compound clove appetizer patch pill, which comprises the following components in parts by weight: Cloves: 5-10 parts; Atractylodes: 10-20 parts; Atractylodes macrocephala and cardamom: 8-15 parts; Amomum villosum: 5-10 portions; Aucklandia: 3-8 parts; Licorice: 5-10 parts; Citrus aurantium: 8-15 parts; Astragalus: 15-25 portions; Chinese yam: 20-30 portions.

6. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 2, characterized in that: The top of the adhesive layer (3) is provided with adhesive glue, which is used to stick the acupoint ironing and moxibustion patch to the patient's skin and keep it from falling off.

7. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 2, characterized in that: A self-adhesive paper is provided on the side of the anti-adhesive layer (1) close to the medicine (2), and both sides of the bottom of the anti-adhesive layer (1) are adhered to the non-woven fabric layer (5).

8. The acupoint ironing and moxibustion patch for treating dwarfism in children combined with the compound clove appetizer patch according to claim 1, characterized in that: The self-heat-generating layer (4) comprises the following components in parts by weight: Iron powder: 60-75 parts; Carbon powder: 5-10 parts; Wood powder: 5-10 parts; Sodium chloride: 1-3 parts; Water: 10-15 parts; Gelatin solution: concentration is 10-15%, used for outer coating.

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