Soothing and repairing composition and application thereof

Abstract

The invention relates to a soothing and repairing composition and application thereof. The soothing and repairing composition comprises a combination of a capparis spinosa fruit extract, a kadsura longepedunculata extract and a radix gentianae extract. The invention creatively discovers that three specific plant extract components, namely the capparis spinosa fruit extract, the kadsura longepedunculata extract and the radix gentianae extract, have a potential synergistic effect, and the three extract components can be mutually influenced and positively act; the synergistic promotion effect, which is unexpected by technicians in the field, on the effects of moisturizing, relieving, repairing and the like is achieved. Therefore, the soothing and repairing composition provided by the invention is very suitable for skin care products, mild, non-irritant and good in stability.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics and relates to a soothing and repairing composition and its application. Background Art

[0002] The skin of the human body is an important barrier to prevent the loss of substances such as body moisture and electrolytes and to block the intrusion of harmful substances from the outside. The integrity of the skin barrier is crucial for maintaining skin health. The skin barrier protects the body from the external environment, including preventing the intrusion of harmful microorganisms, chemicals, pollutants, and physical damage (such as ultraviolet radiation). The skin barrier helps to maintain the moisture of the skin and prevent excessive water loss, thus keeping the skin soft and elastic.

[0003] Frequent irregular living phenomena such as staying up late and overeating, as well as problems such as excessive ultraviolet radiation and excessive skin cleansing, are more likely to cause skin problems such as sensitive skin. The main causes of sensitive skin are as follows: the skin barrier function is damaged, resulting in a decrease in the water content of the stratum corneum, an increase in the transepidermal water loss value (TEWL), and an increase in the permeability of the stratum corneum, so that external substances are more likely to enter the skin and cause irritation; the inflammatory response is aggravated, and excessive external irritating substances penetrate, and the skin synthesizes and releases a large amount of inflammatory mediators, thus triggering a cascading inflammatory response; the reactivity of nerve endings is high, and after inflammation and tissue damage, the release of inflammatory agents activates primary sensory neurons to release peptides and neurotransmitters, making it more likely to receive pain signals mediated by inflammatory factors.

[0004] However, in the current prior art, products with soothing and repairing effects often have a single pathway, and a large amount of raw materials with soothing and repairing effects are added to meet the requirements, and their safety and soothing and repairing effects need to be improved. Therefore, providing a mild type of cosmetics that can efficiently moisturize and have both soothing and repairing effects has important application value. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a soothing and repairing composition and its application, in particular to provide a soothing and repairing composition and its application in cosmetics.

[0006] To achieve the purpose of this invention, the following technical solutions are adopted in the present invention:

[0007] In the first aspect, the present invention provides a soothing and repairing composition, and the soothing and repairing composition includes a combination of Capparis spinosa fruit extract, Kadsura longipedunculata extract, and Gentiana scabra root extract.

[0008] In the present invention, three plant extracts, namely Capparis spinosa fruit extract, Kadsura longipedunculata extract, and Gentiana scabra root extract, are used in combination, and it is found that the three plant extracts can cooperate synergistically and have excellent effects in moisturizing and soothing.

[0009] Among them, the Capparis spinosa fruit extract is rich in stachydrine, which can regulate the intelligent moisturizing pathway, effectively enhance the activity of Capspase14 protease in the short term, accelerate the degradation of filaggrin into natural moisturizing factors for rapid moisturization, inhibit the release of Capspase14 in the long term, effectively increase the reserve of filaggrin, enhance cell vitality, and promote the enhancement of the skin barrier; Kadsura longipedunculata is rich in various polysaccharides and schisandrin B and other broad-spectrum bioactive components, with strong antioxidant activity. While reducing the generation of irritating substances such as free radicals, it can effectively inhibit the secretion of inflammatory factors, significantly inhibit the itching caused by toxins and the release of histamine, and reduce chemical irritant dermatitis; Gentiana root is rich in gentiopicroside, which can inhibit the TRPV1 pathway to block the transmission of information by neurons, avoid the overreaction of sensory nerves, rapidly soothe and relieve, effectively inhibit the release of inflammatory factors to soothe the skin. The three components cooperate with each other and synergistically enhance the effect, and have excellent effects when applied to soothing and repairing cosmetics.

[0010] Preferably, the mass ratio of the Capparis spinosa fruit extract, Kadsura longipedunculata extract and Gentiana root extract is (1-10):(0.5-5):(0.5-5);

[0011] Among them, the above "1-10" can be, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, etc.;

[0012] The above "0.5-5" can be, for example, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc. Other specific point values within this numerical range can be selected and will not be elaborated here one by one.

[0013] In the present invention, when the dosage ratio of each component in the plant extract is within the above specific range, it has a better moisturizing and repairing effect.

[0014] Preferably, the soothing and repairing composition further includes cocoa extract.

[0015] In the present invention, when cocoa extract is further added to the plant extract, its combination with the three extracts of Capparis spinosa fruit extract, Kadsura longipedunculata extract and Gentiana root extract can further improve the moisturizing and repairing effect of the product.

[0016] Preferably, the mass ratio of the Capparis spinosa fruit extract, Kadsura longipedunculata extract, Gentiana root extract and cocoa extract is (1-10):(0.5-5):(0.5-5):(0.005-0.05);

[0017] Among them, the above "1-10" can be, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, etc.;

[0018] The above "0.5 - 5" can be, for example, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc.;

[0019] The above "0.005 - 0.05" can be, for example, 0.005, 0.008, 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.038, 0.045, 0.05, etc. Any other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0020] In the present invention, when the dosage ratio of the added cocoa extract to the other three extracts is within the above - mentioned specific range, it has a better moisturizing and soothing effect.

[0021] The kadsura longipedunculata extract, gentiana root extract, and cocoa extract involved in the present invention are not limited to their specific preparation processes and sources. Products prepared by conventional extraction processes and regular commercially available products can be used in the present invention. Exemplarily, it can be obtained by mixing kadsura longipedunculata, gentiana root, or cocoa plant raw materials with water and / or alcohols, heating and leaching at 65 - 98°C for 1 - 5 h, filtering the leaching solution, collecting the filtrate, and concentrating and drying.

[0022] The capparis spinosa fruit extract involved in the present invention is not limited to its specific preparation process. When it is prepared by the following process, its synergistic effect with the kadsura longipedunculata extract and gentiana root extract in soothing and repairing is more significant.

[0023] Preferably, the capparis spinosa fruit extract is prepared by a preparation method including the following steps:

[0024] Mix capparis spinosa fruit, complex enzyme, and water, perform ultrasonic - assisted enzymatic hydrolysis, filter the solution after enzymatic hydrolysis to obtain a filtrate, and concentrate and dry the filtrate to obtain the capparis spinosa fruit extract;

[0025] The complex enzyme includes a combination of cellulase, macerozyme, and papain.

[0026] In the present invention, it is unexpectedly found that when using a complex enzyme solution containing three enzymes, namely cellulase, macerozyme, and papain, to enzymatically extract the active substances in capparis spinosa fruit, the combination of the three enzymes can synergistically enhance the effect, obtain a better extraction effect, the prepared extract has higher activity and better effects; in addition, the enzymatic hydrolysis is carried out under ultrasonic conditions, which can further improve the enzymatic hydrolysis effect and obtain a capparis spinosa fruit extract with better effects.

[0027] Preferably, the mass ratio of the cellulase, macerozyme, and papain is (1 - 5):(1 - 5):(0.1 - 2);

[0028] Among them, the above "1-5" can be, for example, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc.;

[0029] The above "0.1-2" can be, for example, 0.1, 0.2, 0.4, 0.5, 0.6, 0.8, 1, 1.2, 1.4, 1.5, 1.6, 1.8, 2, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0030] Preferably, the addition amount of the complex enzyme is 0.1‰-1‰ of the mass of the caper fruit, for example, it can be 0.1‰, 0.15‰, 0.2‰, 0.25‰, 0.3‰, 0.5‰, 0.6‰, 0.7‰, 0.8‰, 0.9‰, 1‰, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0031] Preferably, the ratio of the caper fruit to water is 1g:(50-80)mL, for example, it can be 1g:50mL, 1g:55mL, 1g:60mL, 1g:65mL, 1g:70mL, 1g:72mL, 1g:75mL, 1g:80mL, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0032] Preferably, the temperature of the enzymatic hydrolysis is 50-60°C, for example, it can be 50°C, 52°C, 55°C, 58°C, 60°C, etc.; the time is 0.5-2h, for example, it can be 0.5h, 0.8h, 1h, 1.2h, 1.5h, 1.8h, 2h, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0033] Preferably, the power of the ultrasonic wave is 150-450W, for example, it can be 150W, 180W, 200W, 220W, 240W, 260W, 280W, 300W, 320W, 350W, 380W, 400W, 425W, 450W, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0034] In a second aspect, the present invention provides an application of the soothing and repairing composition according to the first aspect in cosmetics.

[0035] Preferably, the cosmetics include lotion, emulsion, cream or essence.

[0036] Preferably, the addition amount of the soothing and repairing composition in the cosmetics is 0.1%-2%, for example, it can be 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2%, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0037] In a third aspect, the present invention provides a soothing and repairing lotion, and the lotion comprises the soothing and repairing composition described in the first aspect.

[0038] Preferably, the lotion further comprises any one or a combination of at least two of emollients, humectants, thickeners, emulsifiers, pH regulators, preservatives or water.

[0039] Preferably, the lotion comprises, by mass parts, 0.1-2 parts of the soothing and repairing composition described in the first aspect, 5-15 parts of an emollient, 5-15 parts of a humectant, 0.1-1.5 parts of a thickener, 1-8 parts of an emulsifier, 0.05-0.2 parts of a pH regulator, 0.5-2 parts of a preservative or 50-80 parts of water, or a combination of any one or at least two of them;

[0040] Among them, the above "0.1-2 parts" can be, for example, 0.1 part, 0.2 part, 0.4 part, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc.;

[0041] The above "5-15 parts" can be, for example, 5 parts, 6 parts, 8 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, etc.;

[0042] The above "0.1-1.5 parts" can be, for example, 0.1 part, 0.2 part, 0.4 part, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, etc.;

[0043] The above "1-8 parts" can be, for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, etc.;

[0044] The above "0.05-0.2 parts" can be, for example, 0.05 part, 0.08 part, 0.1 part, 0.12 part, 0.15 part, 0.18 part, 0.2 part, etc.;

[0045] The above "0.5-2 parts" can be, for example, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc.;

[0046] The above "50-80 parts" can be, for example, 50 parts, 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, 72 parts, 75 parts, 80 parts, etc. Other specific point values within this numerical range can be selected and will not be elaborated one by one here.

[0047] Preferably, the emollient comprises any one or a combination of at least two of squalane, shea butter, pentaerythritol tetra(ethylhexanoate) or polydimethylsiloxane.

[0048] Preferably, the humectant includes any one or a combination of at least two of glycerin, butylene glycol, or betaine.

[0049] Preferably, the thickener includes carbomer and / or ammonium acryloyldimethyltaurate / VP copolymer.

[0050] Preferably, the emulsifier includes any one or a combination of at least two of cetearyl olivate, sorbitan olivate, cetearyl glucoside, cetearyl alcohol, or sodium stearoyl glutamate.

[0051] Preferably, the pH regulator includes arginine and / or citric acid.

[0052] Preferably, the preservative includes any one or a combination of at least two of p-hydroxyacetophenone, sorbic acid, or 1,2-hexanediol.

[0053] Compared with the prior art, the present invention has the following beneficial effects:

[0054] In the present invention, three specific plant extract components, namely Capparis spinosa fruit extract, Kadsura longipedunculata extract, and Gentiana root extract, are used in combination, and it is found that the three components can interact with each other and have a mutually positive influence, and have a synergistic promoting effect that is difficult for those skilled in the art to predict in terms of effects such as moisturizing, soothing, and repairing. When applied to cosmetics, it can further enhance the related effects of the product. Specific Embodiments

[0055] To further elaborate on the technical means and effects adopted by the present invention, the following further illustrates the technical solutions of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0056] The sources of the active ingredients contained in the products involved in the following examples, comparative examples, application examples, and comparative application examples are as follows (only the active ingredients are shown, and other necessary auxiliary ingredients contained in the commercially available raw materials are not elaborated).

[0057]

[0058] Among them, the key active component in the Capparis spinosa fruit extract is stachydrine; the key active components in the Kadsura longipedunculata extract are polysaccharides and schisandrin B components; the key active component in the Gentiana root extract is gentiopicroside; the key active component in the Theobroma cacao extract is cocoa butter; the key active component in the shea butter is stearyl palmitate.

[0059] Preparation Example 1

[0060] This preparation example provides a Capparis spinosa fruit extract, which is prepared by the following method:

[0061] (1) Grind the dried capparis spinosa jelly and mix it with complex enzyme and water. The addition amount of the complex enzyme is 0.5‰ of the mass of capparis spinosa fruit, and the material-liquid ratio of capparis spinosa fruit to water is 1 g:65 mL. The complex enzyme is composed of cellulase, macerozyme and papain with a mass ratio of 3:2:1. Carry out ultrasonic enzymolysis extraction treatment at a constant temperature of 55 °C, and the ultrasonic condition is 300 W for 1.2 h;

[0062] (2) After filtering the ultrasonic extract, collect the filtrate, mix the filter residue with water, repeat the ultrasonic extraction process in step (1) and the filtering step in step (2) once, collect and combine the filtrates, and freeze-dry to obtain the capparis spinosa fruit extract.

[0063] Preparation Example 2

[0064] This preparation example provides a capparis spinosa fruit extract, which is prepared by the following method:

[0065] (1) Grind the dried capparis spinosa jelly and mix it with complex enzyme and water. The addition amount of the complex enzyme is 0.2‰ of the mass of capparis spinosa fruit, and the material-liquid ratio of capparis spinosa fruit to water is 1 g:50 mL. The complex enzyme is composed of cellulase, macerozyme and papain with a mass ratio of 5:1:2. Carry out ultrasonic enzymolysis extraction treatment at a constant temperature of 52 °C, and the ultrasonic condition is 175 W for 1.8 h;

[0066] (2) After filtering the ultrasonic extract, collect the filtrate, mix the filter residue with water, repeat the ultrasonic extraction process in step (1) and the filtering step in step (2) once, collect and combine the filtrates, and freeze-dry to obtain the capparis spinosa fruit extract.

[0067] Preparation Example 3

[0068] This preparation example provides a capparis spinosa fruit extract, which is prepared by the following method:

[0069] (1) Grind the dried capparis spinosa jelly and mix it with complex enzyme and water. The addition amount of the complex enzyme is 1‰ of the mass of capparis spinosa fruit, and the material-liquid ratio of capparis spinosa fruit to water is 1 g:80 mL. The complex enzyme is composed of cellulase, macerozyme and papain with a mass ratio of 1:5:0.2. Carry out ultrasonic enzymolysis extraction treatment at a constant temperature of 58 °C, and the ultrasonic condition is 425 W for 0.5 h;

[0070] (2) After filtering the ultrasonic extract, collect the filtrate, mix the filter residue with water, repeat the ultrasonic extraction process in step (1) and the filtering step in step (2) once, collect and combine the filtrates, and freeze-dry to obtain the capparis spinosa fruit extract.

[0071] Preparation Example 4

[0072] This preparation example provides a Capparis spinosa fruit extract, using the freeze-dried and ground Capparis spinosa fruit of Preparation Example 1. The difference in its preparation method from that of Preparation Example 1 lies only in the enzyme composition in the complex enzyme. The difference is that it does not contain cellulase, and the reduced amount is proportionally distributed to macerozyme and papain. Other treatment processes and related parameters refer to Preparation Example 1.

[0073] Preparation Example 5

[0074] This preparation example provides a Capparis spinosa fruit extract, using the freeze-dried and ground Capparis spinosa fruit of Preparation Example 1. The difference in its preparation method from that of Preparation Example 1 lies only in the enzyme composition in the complex enzyme. The difference is that it does not contain macerozyme, and the reduced amount is proportionally distributed to cellulase and papain. Other treatment processes and related parameters refer to Preparation Example 1.

[0075] Preparation Example 6

[0076] This preparation example provides a Capparis spinosa fruit extract, using the freeze-dried and ground Capparis spinosa fruit of Preparation Example 1. The difference in its preparation method from that of Preparation Example 1 lies only in the enzyme composition in the complex enzyme. The difference is that it does not contain papain, and the reduced amount is proportionally distributed to cellulase and macerozyme. Other treatment processes and related parameters refer to Preparation Example 1.

[0077] Example 1

[0078] This example provides a soothing and repairing composition, which is composed of 5 parts of Capparis spinosa fruit extract (Preparation Example 1), 3 parts of Kadsura longipedunculata extract, and 2 parts of Gentiana root extract by mass.

[0079] Example 2

[0080] This example provides a soothing and repairing composition, which is composed of 1 part of Capparis spinosa fruit extract (Preparation Example 2), 4 parts of Kadsura longipedunculata extract, and 5 parts of Gentiana root extract by mass.

[0081] Example 3

[0082] This example provides a soothing and repairing composition, which is composed of 8 parts of Capparis spinosa fruit extract (Preparation Example 3), 1 part of Kadsura longipedunculata extract, and 1 part of Gentiana root extract by mass.

[0083] Example 4

[0084] This example provides a soothing and repairing composition. The difference from Example 1 is only that the used Capparis spinosa fruit extract (Preparation Example 1) is replaced with an equal amount of Capparis spinosa fruit extract (Preparation Example 4).

[0085] Example 5

[0086] This example provides a soothing and repairing composition, which is only different from Example 1 in that the Capparis spinosa fruit extract (Preparation Example 1) used is replaced with an equal amount of Capparis spinosa fruit extract (Preparation Example 5).

[0087] Example 6

[0088] This example provides a soothing and repairing composition, which is only different from Example 1 in that the Capparis spinosa fruit extract (Preparation Example 1) used is replaced with an equal amount of Capparis spinosa fruit extract (Preparation Example 6).

[0089] Example 7

[0090] This example provides a soothing and repairing composition, which is only different from Example 1 in that the Capparis spinosa fruit extract (Preparation Example 1) used is replaced with an equal amount of commercially available Capparis spinosa fruit extract.

[0091] Example 8

[0092] This example provides a soothing and repairing composition, which is composed of 5 parts of Capparis spinosa fruit extract (Preparation Example 1), 3 parts of Kadsura longipedunculata extract, 2 parts of Gentiana root extract, and 0.02 part of cocoa extract by mass.

[0093] Comparative Example 1

[0094] This comparative example provides a soothing and repairing composition, which is only different from Example 1 in that it does not contain Capparis spinosa fruit extract, and the reduced parts are proportionally distributed to Kadsura longipedunculata extract and Gentiana root extract.

[0095] Comparative Example 2

[0096] This comparative example provides a soothing and repairing composition, which is only different from Example 1 in that it does not contain Kadsura longipedunculata extract, and the reduced parts are proportionally distributed to Capparis spinosa fruit extract and Gentiana root extract.

[0097] Comparative Example 3

[0098] This comparative example provides a soothing and repairing composition, which is only different from Example 1 in that it does not contain Gentiana root extract, and the reduced parts are proportionally distributed to Capparis spinosa fruit extract and Kadsura longipedunculata extract.

[0099] Application Example 1

[0100] This example provides a soothing and repairing lotion, and its formula is as follows:

[0101]

[0102] Its preparation method is:

[0103] (1) Add the emollient and the first emulsifier to the oil-phase pot, and dissolve and mix them evenly at 80 °C to obtain Phase A.

[0104] (2) Dissolve and mix the first humectant, the second emulsifier, the thickener and water evenly at 80 °C to obtain Phase B; dissolve and mix the second humectant and the preservative evenly at 60 °C to obtain Phase C; dissolve and mix arginine and 0.9 parts by mass of water evenly at 60 °C to obtain Phase D.

[0105] (3) Pour Phase A into Phase B, homogenize at 2500 rpm for 5 min, then stir and cool down to 40 °C, and sequentially add Phase C, Phase D and the soothing and repairing composition (Example 1), and stir evenly to obtain the emulsion.

[0106] Application Example 2-8

[0107] This application example provides seven kinds of soothing and repairing lotions. The difference in their formulations from Application Example 1 is only that the compositions prepared in Example 1 are respectively replaced with the compositions prepared in Examples 2-8 in equal amounts, and other ingredients and their contents remain unchanged. The preparation method refers to Application Example 1.

[0108] Application Example 9

[0109] This application example provides a soothing and repairing lotion. The difference in its formulation from Application Example 1 is only that it does not contain squalane, and the reduced components are proportionally distributed to two components, shea butter and betaine, and other ingredients and their contents remain unchanged. The preparation method refers to Application Example 1.

[0110] Application Example 10

[0111] This application example provides a soothing and repairing lotion. The difference in its formulation from Application Example 1 is only that it does not contain shea butter, and the reduced components are proportionally distributed to two components, squalane and betaine, and other ingredients and their contents remain unchanged. The preparation method refers to Application Example 1.

[0112] Application Example 11

[0113] This application example provides a soothing and repairing lotion. The difference in its formulation from Application Example 1 is only that it does not contain betaine, and the reduced components are proportionally distributed to two components, squalane and shea butter, and other ingredients and their contents remain unchanged. The preparation method refers to Application Example 1.

[0114] Comparative Application Example 1-3

[0115] This comparative application example provides three kinds of soothing and repairing lotions. The difference in their formulations from Application Example 1 is only that the compositions prepared in Example 1 are respectively replaced with the compositions prepared in Comparative Examples 1-3 in equal amounts, and other ingredients and their contents remain unchanged. The preparation method refers to Application Example 1.

[0116] Test Example 1

[0117] Compositional Efficacy Test and Screening - Determination of Moisture Absorption and Moisture Retention Properties by Weighing Method

[0118] Determination of moisture absorption rate: Weigh 0.1 g of the soothing and repairing composition (Examples 1 - 8 and Comparative Examples 1 - 3) powder, place it in a small petri dish, put it into a desiccator with a relative humidity (RH) controlled at 81% using ammonium sulfate saturated solution, seal it for 72 h until the sample reaches moisture absorption equilibrium, accurately weigh the sample mass, repeat 3 times, and calculate the moisture absorption rate according to the following formula.

[0119] Moisture absorption rate (%) = (M2 - M1) / M1 × 100%;

[0120] Wherein, M1 is the mass of the sample before moisture absorption (g); M2 is the mass of the sample after moisture absorption (g).

[0121] Determination of moisture retention rate: At 25°C, accurately weigh 0.5 g of the soothing and repairing composition (Examples 1 - 8 and Comparative Examples 1 - 3) powder, put it into a weighing bottle, add deionized water with a mass percentage of 10% of the composition sample powder, and place it in a desiccator containing dry silica gel. The placement time is 2 h, 4 h, and 6 h. Weigh the moisture content and the added moisture content of the sample after placement respectively. Each time, there are 3 replicate tubes, and parallel tests are carried out 2 times. Calculate the moisture retention rate according to the following formula.

[0122] Moisture retention rate (%) = H n / H0 × 100%;

[0123] Wherein, H n is the mass of moisture after water loss during placement (g), and H0 is the mass of added deionized water (g).

[0124] The above test results are all shown in Table 1.

[0125] Table 1

[0126]

[0127]

[0128] It can be seen from the data in the table that:

[0129] (1) It can be seen from Examples 1 to 3 that the composition provided by the present invention has a significant moisture retention effect, and the effect of Example 1 is the best.

[0130] (2) By comparing Example 1 with Examples 4 - 7, it can be seen that the caper fruit extract in the present invention is prepared by a biological enzymolysis method without introducing organic solvents, and an extract product with excellent moisturizing effect is obtained. Furthermore, it is found that when using a composite enzyme containing three enzymes, namely cellulase, macerozyme, and papain, for enzymolysis extraction of caper fruit, the combined use of the three enzymes can synergistically promote the enzymolysis effect, further improve the extraction effect of related active ingredients, and obtain a caper fruit extract with better moisturizing efficacy.

[0131] (3) By comparing Example 1 with Example 8, it can be seen that when further adding cocoa extract to the soothing and repairing composition, its combined use with three extracts, namely caper fruit extract, kadsura longipedunculata extract, and gentiana root extract, can further improve the moisturizing effect of the product.

[0132] (4) By comparing Example 1 with Comparative Examples 1 - 3, it can be seen that when any one of the three components, namely caper fruit extract, kadsura longipedunculata extract, and gentiana root extract, is absent in Comparative Examples 1 - 3, the moisturizing effect of the prepared composition is worse than that of Example 1. It can be known that the combined use of three specific extracts, namely caper fruit extract, kadsura longipedunculata extract, and gentiana root extract, in the present invention can cooperate with each other, synergistically enhance the effect, and improve the moisturizing efficacy of the product.

[0133] Test Example 2

[0134] Emulsion Efficacy Test

[0135] (1) Chinese healthy women with a facial lactic acid stinging test (LAST) score > 3 points, dry, rough, dull, and loose facial skin, and sensitive and flushing facial skin were selected. None of the subjects had allergic diseases or a history of allergies to cosmetics and other topical preparations. The age range of the subjects was 35 - 60 years old, and the average age was 46.3 ± 5.6 years. The subjects were divided into 14 groups, with 6 people in each group.

[0136] (2) After cleansing their faces morning and evening, the subjects took an appropriate amount of the emulsion and evenly applied it to the face, gently massaging until absorbed, twice a day for 28 consecutive days. The changes in the subjects' skin before and after were statistically analyzed to obtain the change rate.

[0137] (2) The test items included:

[0138] Using a skin moisture tester Comeometer CM825 to measure the water content of the skin stratum corneum;

[0139] Using a transepidermal water loss tester Tewameter TM300 to measure the transepidermal water loss value of the skin;

[0140] The Mexamter MX18 (Courage&Khazaka, Germany) skin melanin and heme tester was used to test the skin heme content.

[0141] (3) The test products were the emulsion products prepared in Application Examples 1-11 and Comparative Application Examples 1-3. The test environment was at a temperature of 20°C and a humidity of 50%, meeting the requirements of the protocol design. The improvement rate (%) after using the product = (data after use - data before use) / data before use × 100%. The results are shown in Table 2:

[0142] Table 2

[0143]

[0144]

[0145] According to the data in the table, in the present invention, the combined use of three specific extracts, Capparis spinosa fruit extract, Schisandra sphenanthera extract, and Gentiana root extract, shows a certain synergistic effect in moisturizing and soothing the skin. After adding Theobroma cacao extract to the composition, the related efficacy of the product can be further improved. And when adding three specific components, squalane, shea butter, and betaine, at the same time, the product has better effects than those without any one of these components. In addition, the Capparis spinosa fruit extract prepared by the further method of composite biocatalysis in the present invention has better moisturizing and soothing effects. Among them, the mild extraction method of biocatalysis, without introducing any organic solvents, the obtained extract product has extremely low irritation to the skin when applied to related skin care products, which helps to soothe the skin.

[0146] Test Example 3

[0147] Product safety test

[0148] According to the subject selection criteria, 55 people were selected to participate in the test, with a male-female ratio of 1:1. They were randomly divided into 11 groups (2 males and 3 females in each group) and received the trial respectively. An appropriate amount of the emulsion product prepared in Application Examples 1-11 was placed in the medicine chamber of the patch test tape, and the patch test device with the sample was applied to the flexor side skin of the forearm of the subject with medical tape for 24 hours. 30 minutes after removing the test patch device, after the indentation disappeared, the skin reaction was observed. For those with negative results, the skin reaction was observed again at 24 hours and 48 hours after the test, and the skin reaction results were recorded. The grading standard of the reaction degree is as follows in the table.

[0149]

[0150]

[0151] The results showed that the emulsion products prepared in Application Examples 1-11 showed negative reactions at 24 h and 48 h after the test, and there were no irritation and erythema phenomena. It can be seen that the soothing and repairing emulsion product prepared by the present invention has no irritation to the skin and no positive reaction, proving that the product has a high safety level, low irritation and is relatively mild.

[0152] The applicant declares that the technical solution of the present invention is illustrated by the above embodiments, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvement to the present invention, the equivalent substitution of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the protection scope and the disclosure scope of the present invention.

[0153] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0154] In addition, it should be noted that in the various specific technical features described in the above specific embodiments, they can be combined in any appropriate manner without conflict. To avoid unnecessary repetition, the present invention will not separately describe various possible combination methods.

Claims

1. A soothing and repairing composition, characterized in that: The soothing and repairing composition includes a combination of Capparis spinosa fruit extract, Schisandra chinensis berry extract and Gentiana lutea root extract.

2. The soothing and repairing composition according to claim 1, characterized in that: The mass ratio of the Capparis spinosa fruit extract, the Schisandra chinensis chinensis extract and the Gentiana scabra root extract is (1-10):(0.5-5):(0.5-5).

3. The soothing and repairing composition according to claim 1 or 2, characterized in that: The soothing and repairing composition also includes cocoa extract; Preferably, the mass ratio of the Capparis spinosa fruit extract, Schisandra chinensis chinensis extract, Gentiana scabra root extract and cocoa extract is (1-10):(0.0.5-5):(0.5-5):(0.005-0.05).

4. The soothing and repairing composition according to any one of claims 1 to 3, characterized in that: The caper fruit extract is prepared by a preparation method comprising the following steps: The caper fruit, the complex enzyme and water are mixed, and ultrasound-assisted enzymolysis is performed, after the enzymolysis is completed, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to obtain the caper fruit extract; The complex enzyme comprises a combination of cellulase, malonase and papain.

5. The soothing and repairing composition according to claim 4, characterized in that: The mass ratio of the cellulase, the macerator and the papain is (1-5):(1-5):(0.1-2); Preferably, the added amount of the complex enzyme is 0.1‰-1‰ of the mass of the caper fruit; Preferably, the solid-liquid ratio of the caper fruit to water is 1 g: (50-80) mL.

6. Use of the soothing and repairing composition according to any one of claims 1 to 5 in cosmetics.

7. The use according to claim 6, characterized in that: The cosmetics include lotions, emulsions, creams or essences; Preferably, the soothing and repairing composition is added in an amount of 0.1%-2% in cosmetics.

8. A soothing and repairing lotion, characterized in that: The emulsion comprises the soothing and repairing composition according to any one of claims 1 to 5; Preferably, the emulsion further comprises any one or a combination of at least two of an emollient, a humectant, a thickener, an emulsifier, a pH adjuster, a preservative or water.

9. The soothing and repairing lotion according to claim 8, characterized in that: The emulsion comprises, by mass, any one of 0.1-2 parts of the soothing and repairing composition according to any one of claims 1 to 5, 5-15 parts of an emollient, 5-15 parts of a humectant, 0.1-1.5 parts of a thickener, 1-8 parts of an emulsifier, 0.05-0.2 parts of a pH adjuster, 0.5-2 parts of a preservative or 50-80 parts of water, or a combination of at least two of them.

10. The soothing and repairing lotion according to claim 8 or 9, characterized in that: The emollient comprises any one of squalane, shea butter, pentaerythritol tetra(ethylhexanoate) or polydimethylsiloxane or a combination of at least two thereof; Preferably, the moisturizer comprises any one of glycerin, butylene glycol or betaine, or a combination of at least two thereof; Preferably, the thickener comprises carbomer and / or ammonium acryloyldimethyltaurate / VP copolymer; Preferably, the emulsifier includes any one of cetearyl olivate, sorbitan olivate, cetearyl glucoside, cetearyl alcohol or sodium stearoyl glutamate, or a combination of at least two thereof; Preferably, the pH adjuster comprises arginine and / or citric acid; Preferably, the preservative includes any one of p-hydroxyacetophenone, sorbic acid or 1,2-hexanediol, or a combination of at least two thereof.

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