Intelligent biological kidney dialysis treatment device

Abstract

The invention relates to the technical field of medical treatment, in particular to an intelligent biological renal dialysis treatment device which comprises a data acquisition module, a data monitoring module and a biological renal dialysis module. The data acquisition module is used for acquiring basic information, blood data, historical examination data and treatment data of a patient. The data monitoring module is used for generating a treatment scheme, performing personalized adjustment on the treatment scheme, and transmitting the adjusted treatment scheme to the biological kidney dialysis module; the biological kidney dialysis module comprises a bioreactor unit, a portable unit and a dialysis unit, the bioreactor unit is used for simulating the structure and function of the kidney and assisting a user in blood ultrafiltration, blood transportation, toxin removal, metabolism assistance, endocrine assistance and immunoregulation; the biological kidney dialysis module is further used for receiving the adjusted treatment scheme and adjusting the bioreactor unit according to the adjusted treatment scheme. The structure is complete, and the treatment effect can be improved.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and particularly to an intelligent biological kidney dialysis treatment device. Background Art

[0002] Renal dialysis is an important method for kidney replacement therapy and is a crucial means of maintaining life for many patients with kidney diseases. Renal dialysis is mainly divided into two types: hemodialysis and peritoneal dialysis. Hemodialysis involves drawing the patient's blood out of the body, filtering and removing waste through a dialyzer (artificial kidney), and then returning the purified blood back into the body. Peritoneal dialysis utilizes the peritoneum as a semipermeable membrane. By injecting dialysate into the abdominal cavity, material exchange occurs between the peritoneum and the blood to achieve the purpose of removing waste and excess water.

[0003] Traditional hemodialysis treatment requires patients to undergo treatment three times a week, each time lasting up to four hours. Due to the relatively large volume of existing hemodialysis machines, with a weight of approximately 90 to 120 kilograms, patients need to repeatedly go to the hospital for treatment. Such frequent dialysis not only increases the economic burden on patients but also brings great inconvenience and pain to patients during the long and repeated journey to the hospital, seriously reducing their quality of daily life and mental health.

[0004] Kidney organoids are three-dimensional cell clusters that can simulate the structure and function of the kidney, obtained by inducing stem cell differentiation to grow a microscopic structure similar to the kidney, such as glomeruli, renal tubules, collecting ducts, etc., from a mass of cells. Although these organoids are not real kidneys, they can express various structures similar to human nephrons. Through the design and application of kidney organoids, the convenience of dialysis treatment can be effectively improved.

[0005] In summary, how to solve the problem that the treatment with existing hemodialysis machines is not portable, resulting in patients having to travel back and forth repeatedly for a long time, bringing great inconvenience and pain to patients, and seriously reducing their quality of daily life and mental health has become a difficult problem that urgently needs to be solved in the current field.

[0006] Therefore, it is necessary to propose a convenient and intelligent biological kidney dialysis treatment device. Summary of the Invention

[0007] To solve the above problems, the present invention provides an intelligent biological kidney dialysis treatment device. Through the data acquisition module, it can effectively understand and record the historical conditions of patients, thereby providing a good data basis for the subsequent data monitoring module to analyze the recovery of patients in real time. Then, by using a bioreactor composed of glomerulus-like structures, renal tubule cell-like structures, and stromal cell structures induced and differentiated from stem cells, it can effectively assist patients in metabolism, endocrine, and immune regulation, and with the implantable and portable design, it is convenient for patients to carry, improving the quality of life and mental health of patients.

[0008] To achieve the above object, the technical solution of the present invention is as follows: An intelligent biological kidney dialysis treatment device includes a data acquisition module, a data monitoring module, and a biological kidney dialysis module.

[0009] The data acquisition module is used to collect the basic information, blood data, historical physical examination data, and treatment data of patients, and transmit the basic information, blood data, historical physical examination data, and treatment data of patients to the data monitoring module; the data acquisition module is also used to associate the basic information, blood data, historical physical examination data, and treatment data of the same patient to form case information, store the case information, and construct a case database.

[0010] The data monitoring module is used to retrieve the basic information, blood data, and historical physical examination data of patients in the case database, obtain the case information with the highest similarity, extract the treatment data in the case information, generate a treatment plan according to the treatment data in the case information; the data monitoring module is also used to retrieve the treatment plan with the highest similarity to the current treatment plan in the case database, evaluate the potential risks of the current treatment plan; and according to the characteristic differences between the case information of the current patient and the case information with the highest similarity, combined with the potential risks of the current treatment plan, adjust the treatment plan personalized, and then transmit the adjusted treatment plan to the biological kidney dialysis module.

[0011] The biological kidney dialysis module includes a bioreactor unit, a portable unit, and a dialysis unit; the bioreactor unit is used to simulate the structure and function of the kidney, and assist users in metabolism, endocrine, and immune regulation; the biological kidney dialysis module is also used to receive the adjusted treatment plan and adjust the bioreactor unit according to the adjusted treatment plan.

[0012] Furthermore, the bioreactor unit includes a bioreactor, which is constructed based on self-organizing three-dimensional culture technology using stem cells. The bioreactor contains glomerulus-like structures, renal tubule cell-like structures, and stromal cell structures induced and differentiated from stem cells, and the bioreactor is implanted in the patient's body.

[0013] Furthermore, the data monitoring module is constructed based on a deep learning model, which is trained based on a number of case information.

[0014] Furthermore, the blood data includes blood components, blood pressure, blood flow rate, and blood temperature; the treatment data includes treatment plans, treatment durations, basic vital signs, and rehabilitation conditions.

[0015] Furthermore, the data monitoring module is also used to monitor the changes in the user's blood components, blood pressure, blood flow velocity, and blood temperature in real time; and generate dialysis regulation instructions according to the changes in the user's blood components, blood pressure, blood flow velocity, and blood temperature, and send them to the biological kidney dialysis module.

[0016] Furthermore, the biological kidney dialysis module is also used to receive the dialysis regulation instructions sent by the data monitoring module. After being confirmed by the doctor, it adjusts the composition, flow rate, and temperature of the dialysis fluid in real time according to the dialysis regulation instructions.

[0017] Furthermore, the data acquisition module is also used to summarize all the case databases and construct a blood purification case information registration database.

[0018] The technical principle of the above solution is as follows: The data acquisition module is used to collect the patient's basic information, blood data, historical physical examination data, and treatment data and transmit them to the data monitoring module; the data monitoring module retrieves in the case database according to the patient's basic information, blood data, and historical physical examination data, obtains the case information with the highest similarity, generates a treatment plan according to the treatment data of this case information, and adjusts the treatment plan according to the characteristic differences between the current patient and the historical patient and the potential risks of the current treatment plan, and then transmits the adjusted treatment plan to the biological kidney dialysis module; the biological kidney dialysis module uses the bioreactor unit to perform blood ultrafiltration, blood transportation, foreign body removal, metabolic assistance, endocrine assistance, and immune regulation on the patient according to the adjusted treatment plan to achieve biological kidney dialysis treatment.

[0019] Adopting the above solution has the following beneficial effects: 1. The bioreactor designed by the present invention contains glomerular-like structures, tubular cell structures and matrix cell structures obtained by induced differentiation of stem cells, but does not contain capillary loops and complete glomerular filtration barriers. Its ultrastructure shows obvious podocyte clusters, with podocyte foot processes and slit diaphragms, and the renal tubules form brush border structures and have preliminary reabsorption functions. The cell composition is rich and diverse, including nephron progenitor cells, endothelial cells, podocytes, tubular cells, matrix cells, and a small amount of off-target cells such as glial cells, neurons and muscle progenitor cells. Its cell type is basically similar to fetal kidney cells, which makes the bioreactor provide a good environment for patients' blood ultrafiltration, blood transportation, foreign body removal, metabolic assistance, endocrine assistance and immune regulation. Compared with existing mechanical dialysis devices, it uses bionic principles to achieve better dialysis effects.

[0020] 2. In the prior art, hemodialysis treatment requires patients to undergo hemodialysis three times a week, each time for up to four hours. Since the hemodialysis machines in the prior art are relatively large in size and weigh approximately 90 to 120 kilograms, patients need to go to the hospital repeatedly for treatment. Such treatment methods greatly affect the normal life of patients, and the long-term repeated running around makes it difficult for patients to bear both physically and mentally. The present invention implants the bioreactor into the patient's body in an implantable manner, so that the patient can undergo hemodialysis in a portable manner without the need for repeated running around, thereby effectively improving the patient's quality of life and mental health.

[0021] 3. The present invention can collect important data such as the patient's basic information, past medical history, and current blood data through the design of the data acquisition module, so as to facilitate the subsequent dialysis treatment of the patient, make targeted adjustments according to the patient's specific situation, improve the practicality and pertinence of the treatment plan, and improve the patient's treatment effect. The data acquisition module can also associate various types of data of the same patient to form complete case information, and store it in the case database to facilitate subsequent retrieval and query by doctors. In addition, the module can also summarize the case databases of all hospitals to build a more extensive blood purification case information registry, thereby promoting the standardization, specialization, standardization, and refinement of kidney disease quality control work, improving the homogeneity and overall level of kidney disease medical services, narrowing the gap between regions and hospitals, improving medical services, improving medical quality, and ensuring medical safety.

[0022] 4. The present invention monitors the patient's treatment status in real time through the data monitoring module, and generates dialysis control instructions in real time and sends them to the biological kidney dialysis module. The biological kidney dialysis module adjusts the composition, flow rate and temperature of the dialysate in real time according to the dialysis control instructions; thereby realizing automatic adjustment and real-time adjustment of the treatment plan, or executing it after confirmation by a doctor, providing patients with more targeted treatment plans, thereby achieving better treatment effects.

[0023] 5. Conventional dialysis can only mainly remove small molecule toxins (such as urea and creatinine), but has a poor effect on removing medium and large molecule toxins (such as β2-microglobulin, phosphates, and uremic toxins). The accumulation of these toxins may lead to long-term complications, such as amyloidosis or cardiovascular diseases. In addition, conventional dialysis cannot metabolize hormones in the blood, which may cause problems for patients in terms of hormonal levels and homeostasis. Given these drawbacks, adding a bio-kidney dialysis module to enhance the dialysis effect in the present invention has become a feasible solution. By introducing the bio-kidney dialysis module, toxin removal can be carried out at a deeper level, which can not only remove medium and large molecule toxins, but also promote hormone metabolism, thereby improving the overall health status and quality of life of patients.

[0024] Furthermore, the portable unit includes an elastic portable ring and a controller. The outer side wall of the portable ring is fixedly connected with a dialysis fluid tank, a component analyzer, and a waste fluid tank. The dialysis fluid tank is communicated with the component analyzer, and the component analyzer is communicated with the waste fluid tank. The controller is used to control the opening and closing of the component analyzer to analyze the components of the used dialysis fluid; symmetrically fixed shoulder straps are provided on the portable ring; an adjusting assembly for adjusting the size of the portable ring is arranged inside the portable ring; the bioreactor is detachably connected to the portable ring.

[0025] Beneficial effects: The user can wear the portable ring around the waist and then wear the shoulder straps on both sides on the shoulders, thereby wearing the entire dialysis treatment device portably; the dialysis fluid tank is used to store the dialysis fluid required during dialysis to ensure the continuous progress of the dialysis process. The component analyzer is communicated with the dialysis fluid tank and can analyze the components of the used dialysis fluid, monitor the dialysis effect, ensure the quality of the dialysis fluid and the accuracy of the dialysis process; the waste fluid tank is communicated with the component analyzer and is used to collect the analyzed waste fluid, avoiding environmental pollution and facilitating subsequent treatment.

[0026] Furthermore, the adjusting assembly includes a support rod, a plurality of first connecting rods, and a plurality of second connecting rods. The middle parts of adjacent first connecting rods and second connecting rods are hinged to each other; both sides of the lower end of the support rod are hinged to the adjacent first connecting rods; a sleeve ring is slidably fitted on the upper part of the support rod, and both sides of the sleeve ring are hinged to the adjacent second connecting rods; fixing rings are hinged between adjacent first connecting rods and between adjacent second connecting rods, and the fixing rings are fixedly connected to the inner wall of the portable ring.

[0027] Beneficial effects: In the prior art, although the portable cloth belt can be worn around the patient's waist for the dialysis device, due to the certain weight of the dialysis device, the cloth belt cannot provide good support, which will cause excessive burden on the patient's waist, resulting in discomfort and a sense of compression, and is not conducive to the patient's life. Moreover, the cloth bag may fall off due to the excessive weight of the device, thus causing serious consequences. Compared with the prior art, the portable ring of the present invention has good support and adaptability; when the patient wears the portable ring, the support rod is aligned with the position of the patient's lower back to provide support for the patient's waist. Due to the limitation of the shoulder straps on both sides, the position of the support rod is relatively fixed. Since the portable ring has good elasticity, a number of first connecting rods and a number of second connecting rods will move according to the size of the patient's waist, and the collar will move along the support rod, thereby adjusting the diameter of the portable ring, so that the portable ring can be adjusted according to the patient's waist circumference, ensuring that the portable ring fits closely with the patient's waist, improving the stability and convenience of treatment, and a number of first connecting rods and second connecting rods can further support the entire waist of the patient while adjusting the size of the portable ring.

[0028] Further, the dialysis unit is used for blood ultrafiltration and toxin removal; the dialysis unit includes a filter, and a number of dialysis pipes with a spiral structure are communicated inside the filter.

[0029] Beneficial effects: The filter in the prior art performs dialysis work through straight dialysis pipes, with a small dialysis area and low dialysis efficiency; compared with the filter in the prior art, the present invention can effectively increase the dialysis area through a number of dialysis pipes with a spiral structure, thereby improving the dialysis efficiency and the treatment effect.

[0030] The additional aspects and advantages of the present invention will be partially given in the following description, partially become obvious from the following description, or be understood through the practice of the present invention. Brief Description of the Drawings

[0031] Figure 1 It is a schematic diagram of the system structure of the intelligent biological kidney dialysis treatment device of the present invention.

[0032] Figure 2 It is an axonometric view of the portable ring in the intelligent biological kidney dialysis treatment device of the present invention.

[0033] Figure 3 It is an axonometric view of the adjustment component in the intelligent biological kidney dialysis treatment device of the present invention.

[0034] Figure 4 It is an axonometric view of the filter in the intelligent biological kidney dialysis treatment device of the present invention.

[0035] The reference numerals in the accompanying drawings of the description include: 1, portable loop; 2, dialysate tank; 3, component analyzer; 4, waste liquid tank; 5, shoulder strap; 6, support rod; 7, collar; 8, first connecting rod; 9, second connecting rod; 10, fixing ring; 11, filter; 12, dialysis pipeline. Detailed implementation manners

[0036] The following is a further detailed description through specific implementation manners: Embodiment 1:

[0037] As Figure 1 shown, an intelligent biological kidney dialysis treatment device includes a data acquisition module for collecting various data of a patient, a data monitoring module for detecting various data of the patient, and a biological kidney dialysis module for treating the patient; the data acquisition module, the data monitoring module, and the biological kidney dialysis module are interconnected by signals.

[0038] The specific functions of each module are as follows: The data acquisition module is used to collect the basic information, blood data, historical physical examination data, and treatment data of the patient, and transmit the basic information, blood data, historical physical examination data, and treatment data of the patient to the data monitoring module; the data acquisition module is also used to associate the basic information, blood data, historical physical examination data, and treatment data of the same patient to form case information, and store the case information to construct a case database. The blood data includes blood components, blood pressure, blood flow rate, and blood temperature, where the blood components include creatinine, urea nitrogen, hemoglobin, pH, coagulation factors, thyroxine, and electrolytes, etc. The treatment data includes treatment plans, treatment durations, and rehabilitation conditions. The data acquisition module is also used to summarize all the case databases to construct a blood purification case information registration library.

[0039] In this embodiment, the data acquisition module uses a sphygmomanometer to collect the blood pressure of the patient, uses a blood analyzer to detect the blood type and blood components of the patient, uses a temperature sensor and a flow rate sensor to collect the blood temperature and blood flow rate; uses a memory to store various data.

[0040] In this embodiment, the data acquisition module extracts data from various data sources based on the ETL process, then cleans and transforms these data to make them conform to the standards of the case database, and finally loads the data into the case database. In the ETL process, the relevance of data is mainly reflected in the integration and transformation of data. By cleaning and standardizing data from different sources, the ETL process can ensure that various data of the same patient are associated when entering the case database.

[0041] The data monitoring module is used to retrieve the basic information, blood data, and historical physical examination data of the patient in the case database, obtain the case information with the highest similarity, extract the treatment data in the case information, generate a treatment plan based on the treatment data in the case information, and retrieve the treatment plan with the highest similarity to the current treatment plan in the case database to evaluate the potential risks of the current treatment plan. According to the characteristic differences between the case information of the current patient and the case information with the highest similarity, combined with the potential risks of the current treatment plan, the treatment plan is adjusted personalized, and then the adjusted treatment plan is transmitted to the biological kidney dialysis module for execution after being confirmed by the doctor. The data monitoring module is constructed based on a deep learning model, and the deep learning model is obtained by training based on a number of case information.

[0042] In this embodiment, the deep learning model uses the cosine similarity algorithm to retrieve the treatment plan with the highest similarity to the current treatment plan in the case database, and its specific algorithm is as follows: cos(θ) = (A·B) / (|A|*|B|) (1).

[0043] Among them, A is the feature vector A constructed from the case information of the current user, B is the feature vector B constructed from the case information of the historical user, A·B is the dot product of the feature vectors A and B, and |A| and |B| are the norms of the feature vectors A and B respectively.

[0044] cos(θ) = Σ(A[i]*B[i]) / (√(Σ(A[i]^2))*√(Σ(B[i]^2))) (2).

[0045] Among them, Σ represents the summation operation, and i represents the dimension index of the feature vector.

[0046] The data monitoring module is also used to monitor the changes in the user's blood components, blood pressure, blood flow rate, and blood temperature in real time, and generate a dialysis control instruction based on the changes in the user's blood components, blood pressure, blood flow rate, and blood temperature and send it to the biological kidney dialysis module. In this embodiment, the data monitoring module uses a portable blood pressure monitor to collect the patient's blood pressure, uses a blood analyzer to detect the patient's blood type and blood components, and uses a temperature sensor and a flow sensor to collect the blood temperature and blood flow rate.

[0047] The bio-kidney dialysis module includes a bioreactor unit, a portable unit and a dialysis unit; the bioreactor unit is used to simulate the structure and function of the kidney and assist the user in metabolic assistance, endocrine assistance and immune regulation; the bio-kidney dialysis module is also used to receive the adjusted treatment plan and adjust the bioreactor unit according to the adjusted treatment plan. The bio-kidney dialysis module is also used to receive the dialysis control instructions sent by the data monitoring module and adjust the composition, flow rate and temperature of the dialysate in real time according to the dialysis control instructions.

[0048] In this embodiment, the bioreactor unit includes a bioreactor, which is a kidney organoid. The bioreactor is constructed using stem cells based on self-organizing three-dimensional culture technology. The bioreactor contains a glomerular-like structure, a tubular cell structure and a matrix cell structure obtained by induced differentiation of stem cells; the bioreactor is implanted in the patient's body.

[0049] Its ultrastructure shows obvious podocyte clusters with podocyte foot processes and slit diaphragms. The renal tubules form brush border structures and have preliminary reabsorption functions. The cell composition is rich and diverse, including nephron progenitor cells, endothelial cells, podocytes, tubular cells, and stromal cells. These cell types are richer and closer to the physiological environment and structure of the kidneys than simple tubular epithelial cell lines. This allows the bioreactor to provide a good environment for patients' blood ultrafiltration, blood transport, foreign body removal, metabolic assistance, endocrine assistance, and immune regulation. Compared with existing mechanical dialysis devices, it uses the principle of bionics to achieve better therapeutic effects.

[0050] At the same time, the bioreactor unit with biomimetic design can simulate the selective reabsorption mechanism of the kidney to a certain extent, reducing unnecessary nutrient loss. By using the patient's own stem cells to build the bioreactor unit, the risk of immune rejection can be reduced, providing a more precise treatment plan for patients with renal failure.

[0051] In the prior art, hemodialysis treatment requires patients to undergo hemodialysis three times a week, each time for up to four hours. Since the hemodialysis machine in the prior art is relatively large and weighs approximately 90 to 120 kilograms, patients need to go to the hospital repeatedly for treatment; such treatment greatly affects the normal life of patients, and the long-term repeated running makes it difficult for patients to bear both physically and mentally. In this embodiment, the bioreactor is implanted into the patient's body in an implantable manner, and the patient can perform hemodialysis in a portable manner without having to run around repeatedly, thereby effectively improving the patient's quality of life and mental health.

[0052] Through the design of the data acquisition module, important data such as the basic information of patients, past medical history, and current blood data can be collected, which is convenient for making targeted adjustments according to the specific conditions of patients during subsequent dialysis treatment, improving the practicability and pertinence of the treatment plan, and enhancing the treatment effect of patients. The data acquisition module can also associate various types of data of the same patient to form complete case information and store it in the case database for subsequent retrieval and query by doctors. In addition, this module can summarize all case databases to build a more extensive blood purification case information registration library, thereby promoting the standardization, specialization, standardization, and refinement of the quality control work for kidney diseases, improving the homogenization degree and overall level of kidney disease medical services, narrowing the gap between regions and hospitals, improving medical services, enhancing medical quality, and ensuring medical safety.

[0053] Embodiment 2:

[0054] As Figures 2 - 3 shown, the difference from the above embodiment is that the portable unit includes an elastic portable ring 1 and a controller. A dialysis solution tank 2, a component analyzer 3, and a waste liquid tank 4 are fixedly bonded to the outer side wall of the portable ring 1. The dialysis solution tank 2 is communicated with the component analyzer 3, and the component analyzer 3 is communicated with the waste liquid tank 4. The controller is used to control the opening and closing of the component analyzer 3 to perform component analysis on the used dialysis solution; Shoulder straps 5 are symmetrically and fixedly bonded to the portable ring 1; An adjusting component for adjusting the size of the portable ring 1 is arranged inside the portable ring 1.

[0055] The adjusting component includes a support rod 6, a plurality of first connecting rods 8, and a plurality of second connecting rods 9. The middle parts of adjacent first connecting rods 8 and second connecting rods 9 are hinged to each other; Both sides of the lower end of the support rod 6 are hinged to the adjacent first connecting rod 8; A collar 7 is slidably fitted on the upper part of the support rod 6, and both sides of the collar 7 are hinged to the adjacent second connecting rod 9; Fixing rings 10 are hinged between adjacent first connecting rods 8 and between adjacent second connecting rods 9, and the fixing rings 10 are fixedly bonded to the inner wall of the portable ring 1.

[0056] The bioreactor is engaged with the portable ring 1, and the user can carry the bioreactor conveniently.

[0057] The specific implementation process is as follows: The user can wear the portable ring 1 around the waist, and then wear the shoulder straps 5 on both sides on the shoulders, so as to wear the entire dialysis treatment device portably; the dialysis fluid tank 2 is used to store the dialysis fluid required during dialysis to ensure the continuous progress of the dialysis process. The component analyzer 3 is connected to the dialysis fluid tank 2 and can analyze the components of the used dialysis fluid, monitor the dialysis effect, ensure the quality of the dialysis fluid and the accuracy of the dialysis process; the waste liquid tank 4 is connected to the component analyzer 3 and is used to collect the analyzed waste liquid, avoiding environmental pollution and facilitating subsequent treatment. In this embodiment, a blood analyzer is selected as the component analyzer 3 for component analysis.

[0058] When the patient wears the portable ring 1, the support rod 6 is aligned with the position of the patient's lower back to provide support for the patient's waist. Due to the limitation of the shoulder straps 5 on both sides, the support rod 6 is fixedly bonded to the portable ring 1. Therefore, the position of the support rod 6 is fixed relative to the patient's waist, which is convenient for providing support for the movement of the first connecting rod 8 and the second connecting rod 9 subsequently. Since the portable ring 1 has good elasticity, and the first connecting rod 8 is hinged to the second connecting rod 9, adjacent first connecting rods 8 and adjacent second connecting rods 9 are both hinged to the fixed ring 10; the fixed ring 10 is also fixedly bonded to the portable ring 1. Therefore, with the elasticity of the portable ring 1 as the driving force, all the first connecting rods 8 and the second connecting rods 9 will move according to the size of the patient's waist. The second connecting rod 9 hinged to the collar 7 will pull the collar 7 to move along the support rod 6, thereby adjusting the diameter of the portable ring 1; when the diameter of the patient's waist is larger, the two ends of the first connecting rod 8 and the second connecting rod 9 approach each other, the collar 7 slides downward, and the overall diameter of the portable ring 1 increases. When the diameter of the patient's waist is smaller, the two ends of the first connecting rod 8 and the second connecting rod 9 move away from each other, the collar 7 slides upward, and the overall diameter of the portable ring 1 decreases. The portable ring 1 fits the patient's waist with its own elasticity. At the same time, since the shoulder straps 5 on both sides of the portable ring 1 are located on the patient's shoulders, the shoulder straps 5 can provide a supporting force for the portable ring 1, making the portable ring 1 fixed to the patient's waist. Thus, the portable ring 1 is adjusted according to the patient's waist circumference to ensure that the portable ring 1 fits closely to the patient's waist, improving the stability and convenience of treatment. Moreover, a number of the first connecting rods 8 and the second connecting rods 9 can further support the entire waist of the patient while adjusting the size of the portable ring 1.

[0059] Embodiment 3:

[0060] As Figure 4 shown, the difference from the above embodiment is that the dialysis unit is used for blood ultrafiltration and toxin removal; the dialysis unit includes a filter 11, and a number of dialysis pipes 12 with a spiral structure are connected inside the filter 11.

[0061] The specific implementation process is as follows: The filter 11 in the prior art performs dialysis work through a straight dialysis pipeline 12, with a small dialysis area and low dialysis efficiency. Compared with the filter 11 in the prior art, the dialysis area can be effectively increased through a plurality of dialysis pipelines 12 with spiral structures, thereby improving the dialysis efficiency and the treatment effect.

[0062] Obviously, the above embodiments are merely examples given for clear illustration and are not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or alterations can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. And the obvious changes or alterations derived therefrom are still within the protection scope of the present invention.

Claims

1. An intelligent biological kidney dialysis treatment device, characterized in that: It includes data acquisition module, data monitoring module and biological kidney dialysis module; The data collection module is used to collect the patient's basic information, blood data, historical physical examination data and treatment data, and transmit the patient's basic information, blood data, historical physical examination data and treatment data to the data monitoring module; The data collection module is also used to associate the basic information, blood data, historical physical examination data and treatment data of the same patient to form case information, store the case information and build a case database; The data monitoring module is used to search the patient's basic information, blood data and historical physical examination data in the case database, obtain the case information with the highest similarity, extract the treatment data in the case information, and generate a treatment plan based on the treatment data in the case information; The data monitoring module is also used to retrieve the treatment plan with the highest similarity to the current treatment plan in the case database and evaluate the potential risks of the current treatment plan; According to the characteristic differences between the case information of the current patient and the case information with the highest similarity, combined with the potential risks of the current treatment plan, the treatment plan is adjusted individually, and then the adjusted treatment plan is transmitted to the biological kidney dialysis module; The biological kidney dialysis module includes a bioreactor unit, a portable unit and a dialysis unit; the bioreactor unit is used to simulate the structure and function of the kidney and assist the user in metabolic assistance, endocrine assistance and immune regulation; The biological kidney dialysis module is further used to receive an adjusted treatment plan and adjust the bioreactor unit according to the adjusted treatment plan.

2. The intelligent biological kidney dialysis treatment device according to claim 1, characterized in that: The bioreactor unit includes a bioreactor, which is constructed using stem cells based on self-organizing three-dimensional culture technology; the bioreactor contains a glomerular-like structure, a tubular cell structure and a matrix cell structure obtained by induced differentiation of stem cells; the bioreactor is implanted in the patient's body.

3. The intelligent biological kidney dialysis treatment device according to claim 2 is characterized in that: The data monitoring module is built based on a deep learning model; the deep learning model is trained based on information from several cases.

4. The intelligent biological kidney dialysis treatment device according to claim 3 is characterized in that: Blood data includes blood composition, blood pressure, blood flow rate and blood temperature; treatment data includes treatment plan, treatment duration, basic vital signs and recovery status.

5. The intelligent biological kidney dialysis treatment device according to claim 4 is characterized in that: The data monitoring module is also used to monitor the user's blood composition changes, blood pressure changes, blood flow velocity changes and blood temperature changes in real time; and generate dialysis control instructions based on the user's blood composition changes, blood pressure changes, blood flow velocity changes and blood temperature changes and send them to the biological kidney dialysis module.

6. The intelligent biological kidney dialysis treatment device according to claim 5, characterized in that: The biological kidney dialysis module is also used to receive dialysis control instructions sent by the data monitoring module, and after confirmation by the doctor, adjust the composition, flow rate and temperature of the dialysate in real time according to the dialysis control instructions.

7. The intelligent biological kidney dialysis treatment device according to claim 6, characterized in that: The data collection module is also used to aggregate all case databases and build a blood purification case information registry.

8. The intelligent biological kidney dialysis treatment device according to claim 7, characterized in that: The portable unit comprises an elastic portable ring (1) and a controller. The outer wall of the portable ring (1) is fixedly connected to a dialysate box (2), a component analyzer (3) and a waste liquid box (4). The dialysate box (2) is connected to the component analyzer (3), and the component analyzer (3) is connected to the waste liquid box (4). The controller is used to control the opening and closing of the component analyzer (3) so as to perform component analysis on the dialysate after use. A shoulder strap (5) is symmetrically fixedly connected to the portable ring (1); An adjustment component for adjusting the size of the portable ring (1) is provided inside the portable ring (1); and the bioreactor and the portable ring (1) are detachably connected.

9. The intelligent biological kidney dialysis treatment device according to claim 8, characterized in that: The adjustment assembly comprises a support rod (6), a plurality of first connecting rods (8) and a plurality of second connecting rods (9), wherein the middle portions of adjacent first connecting rods (8) and second connecting rods (9) are hinged to each other; Both sides of the lower end of the support rod (6) are hinged to the first connecting rod (8) adjacent thereto; a collar (7) is slidably fitted on the upper part of the support rod (6), and both sides of the collar (7) are hinged to the second connecting rod (9) adjacent thereto; fixing rings (10) are hinged between adjacent first connecting rods (8) and between adjacent second connecting rods (9), and the fixing rings (10) are fixedly connected to the inner wall of the portable ring (1).

10. The intelligent biological kidney dialysis treatment device according to claim 9, characterized in that: The dialysis unit is used for blood ultrafiltration and toxin removal; the dialysis unit comprises a filter (11), and the filter (11) is connected with a plurality of dialysis pipes (12) with a spiral structure.

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