Device for separating protein in urine

Abstract

The invention relates to the technical field of protein separation, in particular to a device for separating protein in urine, which comprises a rack, mounting racks which are symmetrically arranged are mounted on the rack, a plurality of separation tanks for separating and filtering protein are mounted between the two groups of mounting racks, connectors are mounted on the relatively far sides of the mounting racks, and the connectors are connected with the mounting racks. A stirring mechanism is installed on the machine frame, the input end of the stirring mechanism is communicated with a liquid injection pipeline, the output end of the stirring mechanism is communicated with a liquid guide pipeline, a liquid guide connector is arranged at the tail end, away from the stirring mechanism, of the liquid guide pipeline, and the liquid guide connector is communicated with one end of a connector through a hose. The separation tank is convenient to disassemble and replace, the matched connector is convenient to connect and communicate with the liquid guide connector, use is more convenient and flexible, through the matched design, the separation tank is stable and safe when being connected and installed through the installation frame, the problems of leakage and the like are not prone to occurring when the separation tank is disassembled, and the separation tank is cleaner.

Description

Technical Field

[0001] The present invention relates to the technical field of protein separation, and specifically to a protein separation device in urine. Background Art

[0002] There are mainly two ways to obtain human proteins, urine and blood. Compared with blood, urine is easier to obtain. Through biotechnology development, there are currently a variety of functional human urine protein products successfully developed in human urine, which play a very important role in the medical fields such as the treatment of acute pancreatitis, shock, stroke, myocardial infarction and other clinical critical diseases, assisted reproductive technology, burn and plastic wound repair, etc.

[0003] Chinese Patent Publication No.: CN117398719A, discloses a protein separation device for collecting urine and its control system, including a frame; a pre-adjustment device, the pre-adjustment device includes a pre-adjustment bin, a sensor, a liquid outlet regulating valve and a stock solution pump, the pre-adjustment bin is arranged on the frame, an adsorption device, the adsorption device includes a diversion pipe, an adsorption column, a pressure sensor and a regulating valve, the diversion pipe is used to connect the adsorption device and the pre-adjustment device, and the adsorption column is used to adsorb proteins in urine.

[0004] In this solution, after using for a period of time, when the amount of proteins adsorbed on the adsorption column is relatively large, the adsorption column needs to be replaced for continuous use. However, during this process, when the adsorption column is removed, the urine in it will drip out, thus polluting the workplace. Summary of the Invention

[0005] The purpose of the present invention is to provide a protein separation device in urine to solve the problems raised in the above background art.

[0006] To achieve the above purpose, the present invention provides the following technical solutions: A protein separation device in urine, including a frame, symmetrically arranged mounting brackets are installed on the frame, a plurality of separation tanks for protein separation and filtration are installed between the two mounting brackets, connection heads are installed on the relatively far sides of the mounting brackets, a stirring mechanism is installed on the frame, the input end of the stirring mechanism is communicated with a liquid injection pipeline, the output end of the stirring mechanism is communicated with a liquid guiding pipeline, a liquid guiding joint is provided at the end of the liquid guiding pipeline far from the stirring mechanism, and the liquid guiding joint is communicated with one end of a connection head through a hose.

[0007] As a further solution of the present invention: a first filter is communicated on the liquid injection pipeline, a liquid injection joint is provided at the end of the liquid injection pipeline far from the stirring mechanism, a second filter is communicated on the liquid guiding pipeline, and a water pump is communicated on the liquid guiding pipeline.

[0008] As a further solution of the present invention: a control mechanism is also installed on the frame.

[0009] As a further solution of the present invention: the mounting bracket includes a frame plate, and a plurality of liquid guide holes are penetratingly provided on the frame plate. An installation flange is provided at one side edge of the frame plate, and a plurality of groups of threaded holes for installation are penetratingly provided on the installation flange. An assembly groove for installing the separation tank is embedded on one side surface of the frame plate, and the assembly groove is communicated with the liquid guide holes. A fixing plate for cooperatively fixing the separation tank is assembled and connected to the side of the frame plate.

[0010] As a further solution of the present invention: rotating rods are symmetrically and rotatably connected to both sides of the fixing plate, and limit holes for limiting and cooperating with the rotating rods are embedded on the side of the frame plate.

[0011] As a further solution of the present invention: a limit convex block is provided on one side of the end of the rotating rod away from the fixing plate. A torsion spring groove is embedded on the periphery of the part of the rotating rod rotatably connected inside the fixing plate. A torsion spring is connected between the torsion spring groove and the fixing plate. The limit hole is slidably adapted to the rotating rod. A guide hole slidably adapted to the limit convex block is further provided on the upper side of the limit hole along the extending direction of the limit hole. A circular groove with a radius equal to the sum of the radii of the rotating rod and the limit convex block is also provided at the end of the guide hole and the limit hole.

[0012] As a further solution of the present invention: the connecting head includes a pipe body. One end of the pipe body is open, and an assembly flange for cooperative installation is provided on the periphery. The other end of the pipe body is closed. The side of the pipe body is respectively communicated with a plurality of liquid guide holes through connecting pipes. A valve is provided between two connecting pipes near the assembly flange on one side inside the pipe body. One of the pipe bodies is communicated with the liquid guide joint through a hose through the assembly flange.

[0013] As a further solution of the present invention: the separation tank includes a tank body, and tank covers are assembled and connected to both ends of the tank body. A conduit is slidably penetrated through the tank covers. A separation filler is filled in the tank body. A sealing plate opposite to the conduit is installed on one side of the tank cover inside the tank body. A spring is connected between the end of the conduit extending into the tank cover and the tank cover, and the spring acts to make the end of the conduit fit against the surface of the sealing plate.

[0014] As a further solution of the present invention: adjustment grooves are symmetrically embedded on both sides of the periphery of the conduit, and the adjustment grooves are arranged along the axial direction of the conduit. A lining ring is slidably sleeved on the periphery of the conduit, and adjustment protrusions slidably adapted to the adjustment grooves are protruded on the inner side of the lining ring.

[0015] As a further solution of the present invention: The assembly groove includes a clamping groove embedded in the side of the frame plate. One end of the clamping groove penetrates the side of the frame plate, and the other end of the clamping groove is in an arc shape adapted to the edge of the conduit. A limiting groove is embedded in the inner wall of the clamping groove, and the limiting groove is slidably adapted to the lining ring.

[0016] As a further solution of the present invention: A clamping plate is fixedly connected to the side of the fixing plate facing the clamping groove. The clamping plate is slidably adapted to the clamping groove, and the end of the clamping plate facing the clamping groove is arc-shaped and adapted to the periphery of the conduit.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: During use, since the separation tank needs to be frequently removed and replaced to continuously perform protein separation on urine. Therefore, through the design of the mounting rack, the separation tank can be conveniently disassembled and replaced, and it is convenient to connect and communicate with the liquid guiding joint through the connecting head, making it more convenient and flexible during use. And through the above-mentioned cooperative design, when the separation tank is connected and installed through the mounting rack, it is stable and safe, and when it is disassembled, problems such as leakage are not likely to occur, and it is cleaner. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of the present invention.

[0019] Figure 2 It is a structural schematic diagram of the mounting rack in the present invention.

[0020] Figure 3 It is a structural schematic diagram of the frame plate in the present invention.

[0021] Figure 4 It is Figure 3 An enlarged structural schematic diagram of area A in

[0022] Figure 5 It is a structural schematic diagram of the fixing plate in the present invention.

[0023] Figure 6 It is a structural schematic diagram of the rotating rod in the present invention.

[0024] Figure 7 It is a structural schematic diagram of the connection structure of the mounting rack, the separation tank and the connecting head in the present invention.

[0025] Figure 8 It is a structural schematic diagram of the separation tank in the present invention.

[0026] Figure 9 It is Figure 8 An enlarged structural schematic diagram of area B in

[0027] Figure 10 It is a sectional view of the separation tank in the present invention.

[0028] In the figure: 1 - frame, 2 - control mechanism, 3 - stirring mechanism, 4 - liquid injection pipeline, 41 - first filter, 42 - liquid injection joint, 5 - liquid guiding pipeline, 51 - second filter, 52 - water pump, 53 - liquid guiding joint, 6 - mounting bracket, 61 - bracket plate, 62 - liquid guiding hole, 63 - mounting flange, 64 - fixing plate, 6401 - clamping plate, 65 - rotating rod, 6501 - torsion spring groove, 6502 - limiting projection, 66 - limiting hole, 6601 - guiding hole, 67 - assembly groove, 6701 - clamping groove, 6702 - limiting groove, 6703 - inclined surface, 7 - connecting head, 71 - pipe body, 72 - assembly flange, 73 - connecting pipe, 8 - separation tank, 81 - tank body, 82 - tank cover, 83 - conduit, 8301 - adjusting groove, 84 - lining ring, 8401 - adjusting projection, 85 - separation filling, 86 - sealing plate. Detailed implementation manner

[0029] Please refer to Figures 1 - 3, in the embodiments of the present invention, a protein separation device in urine includes a frame 1. On the frame 1, symmetrically arranged mounting brackets 6 are installed. Between the two groups of mounting brackets 6, multiple separation tanks 8 for protein separation and filtration are installed. Preferably, three groups of the separation tanks 8 are provided. On the relatively far - away sides of the mounting brackets 6, connection heads 7 are installed. The separation tanks 8 are sequentially connected through the mounting brackets 6 and the connection heads 7. On the frame 1, a stirring mechanism 3 is installed. The stirring mechanism 3 is a device commonly used in the prior art for stirring urine. On the stirring mechanism 3, a detection module for detecting the pH value of the internal liquid is integrally provided, a detection module for detecting the conductivity of the internal urine is also integrally provided, and a flowmeter for detecting the flow rate of the internal urine is also integrally provided. The input end of the stirring mechanism 3 is connected to a liquid injection pipeline 4, and urine is injected into the stirring mechanism 3 through the liquid injection pipeline 4. Since the stirring mechanism 3 uses a mature device in the prior art, its internal structure will not be described in detail. The output end of the stirring mechanism 3 is connected to a liquid guiding pipeline 5. After urine is stored in the stirring mechanism 3 for a period of time (the specific time is further defined according to production design), it is discharged through the liquid guiding pipeline 5. For convenience, solenoid valves can be provided at the connection points of the liquid injection pipeline 4 and the liquid guiding pipeline 5 with the stirring mechanism 3 to control the connection. A first filter 41 is connected to the liquid injection pipeline 4 to filter the urine injected into the stirring mechanism 3. A water pump 52 is also connected to the liquid guiding pipeline 5, and the urine flowing from the stirring mechanism 3 into the liquid guiding pipeline 5 can be filtered again. A water pump 52 for pumping out the urine in the stirring mechanism 3 is also connected to the liquid guiding pipeline 5. The end of the liquid guiding pipeline 5 far from the stirring mechanism 3 is provided with a liquid guiding joint 53, and the end of the liquid injection pipeline 4 far from the stirring mechanism 3 is provided with a liquid injection joint 42. The liquid injection joint 42 is used to connect to the urine injection end. The liquid guiding joint 53 is connected to one end of a connection head 7 through a hose (not shown in the figure). After the urine is processed by the separation tank 8 for protein separation, the waste liquid is discharged from the end of the other connection head 7. Preferably, both the first filter 41 and the second filter 51 can use activated carbon filtration.

[0030] Preferably, a control mechanism 2 is also installed on the frame 1. The control mechanism 2 is electrically connected to the stirring mechanism 3 and various sensors on the stirring mechanism 3, etc., so that various parameters can be understood in real - time to facilitate control and adjustment. The control mechanism 2 is composed of a hardware system and a display control system. This part is a monitoring and control device, which is composed of a software system and hardware in the prior art, and its structure will not be described in detail here.

[0031] During use, since the separation tank 8 needs to be frequently removed and replaced to continuously separate proteins from urine. Therefore, through the design of the mounting bracket 6, the disassembly and replacement of the separation tank 8 can be facilitated, and it is convenient to connect and communicate with the liquid guiding joint 53 through the connector 7, making it more convenient and flexible during use. Through the above-mentioned combined design, when the separation tank 8 is connected and installed through the mounting bracket 6, it is stable and safe, and when disassembled, problems such as leakage are not likely to occur, and it is cleaner.

[0032] Specifically, as Figures 2 - 3 and Figure 6 shown, the mounting bracket 6 includes a frame plate 61, and a plurality of liquid guiding holes 62 are penetratingly provided on the frame plate 61. An installation flange 63 is provided at one side edge of the frame plate 61, and a plurality of groups of threaded holes for installation are penetratingly provided on the installation flange 63. An assembly groove 67 for installing the separation tank 8 is embedded on one side surface of the frame plate 61, and the assembly groove 67 is communicated with the liquid guiding holes 62. A fixing plate 64 for cooperatively fixing the separation tank 8 is assembled and connected to the side of the frame plate 61. Among them, rotating rods 65 are symmetrically and rotatably connected to both sides of the fixing plate 64, and a limiting hole 66 for limiting cooperation with the rotating rod 65 is embedded on the side of the frame plate 61. Further, a limiting convex block 6502 is provided on one end side of the rotating rod 65 away from the fixing plate 64, and a torsion spring groove 6501 is embedded on the periphery of the part of the rotating rod 65 rotatably connected inside the fixing plate 64. A torsion spring is connected between the torsion spring groove 6501 and the fixing plate 64. The limiting hole 66 and the rotating rod 65 are slidably adapted. Along the extending direction of the limiting hole 66, a guiding hole 6601 slidably adapted to the limiting convex block 6502 is further provided on the upper side of the limiting hole 66. A circular groove with a radius equal to the sum of the radii of the rotating rod 65 and the limiting convex block 6502 is also provided at the end of the guiding hole 6601 and the limiting hole 66. The torsion spring acts on the angle at which the limiting convex block 6502 deviates from the guiding hole 6601. During use, the two ends of the separation tank 8 can be aligned and installed with the upper and lower assembly grooves 67 respectively, and then the rotating rod 65 is rotated to align the limiting convex block 6502 with the guiding hole 6601. At this time, the rotating rod 65 can be inserted into the limiting hole 66, and the fixing plate 64 is used in cooperation with the assembly groove 67 to fix the end of the separation tank 8. Then, after the rotating rod 65 is released, the limiting convex block 6502 rotates in the circular groove, thereby realizing the limit, and at this time, the fixation of the separation tank 8 can be maintained. The frame plate 61 can be installed on the frame 1 through the threaded holes on the installation flange 63, and the installation is stable and convenient. The side of the liquid guiding hole 62 away from the assembly groove 67 can be communicated with the connector 7.

[0033] In order to ensure the sequential connection of the separation tank 8, as Figure 7As shown, the connector 7 includes a tube body 71, one end of which is open and the outer periphery is provided with an assembly flange 72 for matching installation, and the other end of the tube body 71 is closed. The sides of the tube body 71 are respectively connected to the multiple liquid guide holes 62 through the connecting pipes 73. A valve is provided between the two connecting pipes 73 near the side of the assembly flange 72 in the tube body 71, and one of the tube bodies 71 is connected to the liquid guide joint 53 through the assembly flange 72 through a hose. After the valves on the two tube bodies 71 are closed, the urine after pre-treatment such as filtration enters the separation tank 8 from one end of one of the tube bodies 71. Through adsorption and other methods, the protein is filtered and retained in the separation tank 8. After the urine passes through multiple separation tanks 8 in sequence, the waste liquid is discharged through the end of another tube body 71. During the whole process, the operation is simple and convenient. According to needs, multiple separation tanks 8 can be selected to be used in series or in parallel.

[0034] In order to ensure cleanliness during use, the separation tank 8 includes a tank body 81, and a tank cover 82 is assembled and connected at both ends of the tank body 81. A conduit 83 is slidably penetrated on the tank cover 82. The tank body 81 is filled with a separation filler 85. A sealing plate 86 opposite to the conduit 83 is installed on one side of the tank cover 82 located in the tank body 81. A spring is connected between the end of the conduit 83 extending into the tank cover 82 and the tank cover 82, and the end of the spring-acting conduit 83 is attached to the surface of the sealing plate 86. When in use, the conduit 83 and the assembly groove 67 are slidably adapted, and the opening and the liquid guide hole 62 can be connected when aligned. When the conduit 83 and the assembly groove 67 are matched, the conduit 83 can be pulled away from the tank body 81, so that the inside of the tank body 81 can be connected to the outside through the conduits 83 at both ends. In this way, the connection and protein separation can be kept smooth during use. Once the separation tank 8 needs to be replaced, the conduit 83 is separated from the matching between the assembly groove 67, and the spring at the end of the conduit 83 can retract the end of the conduit 83 into the tank body 81 and abut against the surface of the sealing plate 86 to form a blockage, thereby preventing the liquid in the tank body 81 from leaking out, and making it cleaner when replacing. The separation filler 85 is preferably filled with silicone material.

[0035] Among them, adjustment grooves 8301 are symmetrically embedded on both sides of the outer periphery of the conduit 83, and the adjustment grooves 8301 are arranged along the axial direction of the conduit 83. A liner ring 84 is slidably sleeved on the outer periphery of the conduit 83, and an adjustment protrusion 8401 is protrudingly arranged on the inner side of the liner ring 84 to slide with the adjustment groove 8301. The cooperation between the adjustment protrusion 8401 and the adjustment groove 8301 can limit the relative rotation between the liner ring 84 and the conduit 83, and the liner ring 84 can pull the conduit 83 to slide relative to the tank cover 82.

[0036] like Figures 3 - 5As shown, the assembly groove 67 includes a clamping groove 6701 embedded in the side of the frame plate 61. One end of the clamping groove 6701 penetrates the side of the frame plate 61, and the other end of the clamping groove 6701 is in an arc shape adapted to the edge of the conduit 83. A limiting groove 6702 is embedded in the inner wall of the clamping groove 6701, and the limiting groove 6702 is slidably adapted to the lining ring 84. After the lining ring 84 on the conduit 83 is aligned with one side of the limiting groove 6702, the conduit 83 and the lining ring 84 are gradually slid into the clamping groove 6701 and the limiting groove 6702. There is an inclined surface 6703 in the frame plate 61 within the clamping groove 6701. When the separation tank 8 is installed between the upper and lower mounting frames 6, the conduit 83 is in a state of being stretched away from the tank body 81. When the conduit 83 and the lining ring 84 are initially slid into the clamping groove 6701 and the limiting groove 6702, the absence of the obstruction of the inclined surface 6703 facilitates the adjustment of the positions of the conduit 83 and the lining ring 84. As they are gradually slid in, the inclined surface 6703 can adjust the degree to which the conduit 83 is away from the tank body 81. Such a setting avoids the conduit 83 being overly pulled out of the tank body 81 and the spring from being deformed excessively and failing. The absence of the inclined surface 6703 at the opening of the clamping groove 6701 is for the convenience of the cooperation between the conduit 83 and the lining ring 84 and the clamping groove 6701 and the limiting groove 6702, making the assembly more convenient, and the sliding fit between the adjustment groove 8301 and the adjustment protrusion 8401 can also be adjusted in cooperation. Further, a clamping plate 6401 is fixedly connected to the side of the fixing plate 64 facing the clamping groove 6701. The clamping plate 6401 is slidably adapted to the clamping groove 6701, and the end of the clamping plate 6401 facing the clamping groove 6701 is arc-shaped and adapted to the outer periphery of the conduit 83. Through such a design, it is convenient to cooperate and fix the conduit 83, improving the placement stability of the tank body 81.

Claims

1. A protein separation device in urine, comprising a frame, on which a stirring mechanism is installed, the input end of the stirring mechanism is connected to a liquid injection pipeline, and the output end of the stirring mechanism is connected to a liquid guide pipeline, characterized in that: The frame is provided with symmetrically arranged mounting frames, a plurality of separation tanks for protein separation and filtration are installed between two groups of mounting frames, a connector is installed on the relatively distant side of the mounting frames, a liquid conducting joint is provided at the end of the liquid conducting pipeline away from the stirring mechanism, and the liquid conducting joint is connected to one end of a connector through a hose.

2. The device for separating protein from urine according to claim 1, characterized in that: The liquid injection pipeline is connected to a first filter, the end of the liquid injection pipeline away from the stirring mechanism is provided with a liquid injection joint, the liquid guide pipeline is connected to a second filter, and the liquid guide pipeline is connected to a water pump.

3. The device for separating protein from urine according to claim 1, characterized in that: A control mechanism is also installed on the frame.

4. The device for separating protein from urine according to claim 1, characterized in that: The mounting frame includes a frame plate, a plurality of liquid guide holes are provided on the frame plate, a mounting flange is provided on one edge of the frame plate, a plurality of groups of threaded holes for mounting are provided on the mounting flange, an assembly groove for mounting a separation tank is embedded in one side of the frame plate, the assembly groove is connected to the liquid guide holes, and a fixing plate for cooperating with and fixing the separation tank is provided on the side of the frame plate.

5. The device for separating protein from urine according to claim 4, characterized in that: The fixing plate is provided with rotating rods symmetrically and rotatably connected on both sides, and the side edges of the frame plate are embedded with limiting holes that cooperate with the rotating rods.

6. The device for separating protein from urine according to claim 5, characterized in that: A limiting protrusion is provided on one side of the end of the rotating rod away from the fixed plate, and a torsion spring groove is embedded in the outer periphery of the rotating rod rotatably connected to the fixed plate, a torsion spring is connected between the torsion spring groove and the fixed plate, the limiting hole and the rotating rod are slidably adapted, and a guide hole slidably adapted to the limiting protrusion is also provided on the upper side of the limiting hole along the extension direction of the limiting hole, and a circular groove with a radius the same as the sum of the radii of the rotating rod and the limiting protrusion is also provided at the ends of the guide hole and the limiting hole.

7. A device for separating protein from urine according to claim 4 or 6, characterized in that: The connector includes a tube body, one end of which is open and has an assembly flange for matching installation on the periphery, the other end of which is closed, the sides of the tube body are connected to multiple liquid guide holes through connecting pipes, a valve is provided between two connecting pipes on the side of the tube body close to the assembly flange, and one of the tube bodies is connected to the liquid guide joint through a hose through the assembly flange.

8. A device for separating protein from urine according to claim 4 or 6, characterized in that: The separation tank comprises a tank body, with tank covers assembled and connected at both ends of the tank body, a conduit slidingly penetrated on the tank cover, a separation filler provided in the tank body, a sealing plate opposite to the conduit installed on one side of the tank cover located in the tank body, a spring connected between the end of the conduit extending into the tank cover and the tank cover, and the spring acts on the end of the conduit to fit the surface of the sealing plate.

9. The device for separating protein from urine according to claim 8, characterized in that: Adjustment grooves are symmetrically embedded on both sides of the outer periphery of the catheter, and the adjustment grooves are arranged along the axial direction of the catheter. A liner ring is provided on the outer periphery of the catheter for sliding. An adjustment protrusion that is slidably matched with the adjustment groove is protruded from the inner side of the liner ring.

10. The device for separating protein from urine according to claim 9, characterized in that: The assembly groove includes a card slot embedded in the side of the frame plate, one end of the card slot passes through the side of the frame plate, and the other end of the card slot is in an arc shape that matches the edge of the catheter. The inner wall of the card slot is embedded with a limiting groove, and the limiting groove and the lining ring are slidably matched; the fixing plate is also fixedly connected to a card plate facing the card slot, and the card plate and the card slot are slidably matched, and the end of the card plate facing the card slot is matched with the outer arc of the catheter.

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