Molecular biology sample grinding device

Abstract

The invention relates to the technical field of grinding equipment, and discloses a molecular biology sample grinding device which comprises a screw feeding type grinding mechanism and a grinding pressure adjusting mechanism. And a longitudinal hollow shell which is fixedly mounted in the first component mounting opening and is in a hollow state, a spiral spring which is placed in the longitudinal hollow shell and is in a compressed state, a longitudinal telescopic rod which can exert upward elastic acting force on the lower grinding disc, and an external threaded rod which can change the elastic pressure of the spiral spring are arranged in the lower grinding disc. According to the molecular biology sample grinding device, elastic grinding pressure can be generated on biological samples, the pressure is adjustable, so that a worker can adjust the grinding pressure according to the pressure borne by different samples, in addition, the device can realize a grinding path from inside to outside, and the grinding efficiency is improved. Therefore, the one-time grinding effect on the biological sample can be achieved, and the grinding efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of powder grinding equipment, and particularly to a molecular biology sample powder grinding device. Background Art

[0002] In the prior art, a sample powder grinding device is used in molecular biology test detection work to facilitate subsequent observation and detection work. The existing laboratory simple powder grinding device in the prior art realizes the powder grinding work by manually applying pressure for grinding, with low work efficiency and unable to well meet the actual needs of people.

[0003] For this reason, the Chinese patent with the publication number "CN211755782U" discloses a "molecular biology sample powder grinding device", the main structure of which includes an outer frame in the shape of a semi-square-shaped bent plate. A round table base and a grinding tool are arranged in the inner cavity of the outer frame. The lower end of the round table base is fixedly connected to the outer frame, the upper end of the round table base is provided with a grinding tool, the upper end of the grinding tool is provided with a lifting column, the upper end of the lifting column penetrates through the outer frame, a control device is arranged between the grinding tool and the lifting column, and the lower end of the control device extends into the grinding tool. A transmission device is arranged at the upper end of the outer frame, and the lower end of the transmission device contacts the lifting column. When the molecular biology sample powder grinding device is in use, the biological sample to be ground is placed in the conical groove on the grinding tool seat. Manually rotate the grinding tool. Due to the spring rebound, the conical part of the original grinding tool will fit with the conical groove of the grinding tool seat. In this way, the sample is padded in the conical groove of the grinding tool seat. Rotate the grinding tool, and through the misaligned grinding between the grinding tool and the grinding tool seat, the powder grinding work is realized. At the same time, the rotation of the grinding tool drives the annular gear, and through the transmission of gear one, the worm rotates, and then drives gear two to rotate. The top body is controlled to rotate through the shaft rod. During the rotation of the top body, the lifting column is gradually jacked up. In this way, during the rotation of the top body, the lifting column repeatedly rises and falls, and pressure is applied to the control block through the spring, thereby controlling the grinding tool. In this way, during the cooperative grinding of the grinding tool and the grinding tool seat, the grinding tool gradually applies pressure to the sample to achieve sufficient grinding.

[0004] It can be known from the above description that when the above-mentioned molecular biology sample powder grinding device grinds, the biological sample needs to be placed in the conical groove on the grinding tool seat. And during the grinding process, due to the grinding pressure from the center, the sample particles will move outward, resulting in some larger particles not being ground in time. It is necessary to repeatedly move the particles located on the periphery to the grinding center to achieve a more refined grinding effect. Therefore, its grinding efficiency is low. Summary of the Invention

[0005] In view of the deficiencies of the prior art, the present invention provides a molecular biology sample grinding device, which can generate elastic grinding pressure on biological samples, and this pressure is adjustable, so that the staff can adjust the grinding pressure according to the pressure received by different samples. In addition, the device can realize the grinding path from the inside to the outside, so as to achieve a one-time grinding effect on biological samples, improve the grinding efficiency, and solve the above technical problems.

[0006] To achieve the above object, the present invention provides the following technical solution: A molecular biology sample grinding device includes a bottom support base, a first fixed substrate fixedly installed above the bottom support base through a first support rod, a first component installation port provided at the center of the first fixed substrate, a second fixed substrate fixedly installed on the upper surface of the bottom support base and directly above the first fixed substrate through a second support rod, a second component installation port provided at the center of the second fixed substrate, a third fixed substrate fixedly installed directly above the second fixed substrate through a third support rod, and a rotor perforation provided at the center of the third fixed substrate. It also includes a screw feeding type grinding mechanism, which internally has an upper grinding disc and a lower grinding disc that can grind molecular samples when rotating relatively, a material storage housing fixedly installed on the upper surface of the upper grinding disc and in the second component installation port, which can pre-store sample materials, a driving motor fixedly installed on the upper surface of the third fixed substrate, and a screw placed in the material storage housing and capable of rotating with the rotor of the driving motor and driving the sample inside the material storage housing to be conveyed downward; and a grinding pressure adjustment mechanism, which internally has a longitudinal hollow housing fixedly installed in the first component installation port and in a hollow state, a helical spring placed inside the longitudinal hollow housing and in a compressed state, a longitudinal telescopic rod that can exert an upward elastic force on the lower grinding disc, and an external threaded rod that can change the elastic pressure of the helical spring.

[0007] Preferably, the screw feeding type grinding mechanism includes a motor fixing seat fixedly installed on the upper surface of the third fixed substrate, an upper grinding disc and a lower grinding disc symmetrically arranged up and down. An inverted driving motor is fixedly installed inside the motor fixing seat. The rotor of the driving motor penetrates through the motor fixing seat and the rotor perforation. An axially installed groove with an inward concave structure is provided at the center of the bottom end of the lower grinding disc. A material storage housing integrally structured with the upper grinding disc is provided on the upper surface of the upper grinding disc. A funnel-shaped cavity with an open top is provided in the top area of the material storage housing. A material conveying cavity with an open bottom end and a top end communicating with the bottom end of the funnel-shaped cavity is provided in the bottom area of the material storage housing and the inside of the upper grinding disc. The bottom end of the screw is installed through a coupling with a screw located inside the funnel-shaped cavity and the material conveying cavity.

[0008] Preferably, the structural radius of the upper port of the funnel-shaped cavity is greater than that of its lower port, and the structural radius of the lower port of the funnel-shaped cavity is the same as that of the material conveying cavity.

[0009] Preferably, after the driving motor is started, the rotation of the screw causes the material around it to have a downward conveying direction.

[0010] Preferably, the grinding pressure adjusting mechanism includes a longitudinal hollow housing fixedly installed in the first component installation port. A longitudinal component moving cavity is provided inside the longitudinal hollow housing. An internal threaded hole communicating with the bottom end of the longitudinal component moving cavity is provided at the bottom end of the longitudinal hollow housing. A rod body through hole communicating with the top end of the longitudinal component moving cavity is provided at the top end of the longitudinal hollow housing. A lower limit plate and an upper limit plate capable of moving axially along the longitudinal component moving cavity are placed inside the longitudinal hollow housing in the longitudinal component moving cavity. A helical spring in a compressed state is placed between the lower limit plate and the upper limit plate. The bottom end of the lower limit plate is installed with a rotatable external threaded rod through a bearing. The rod body of the external threaded rod is installed in the internal threaded hole through a threaded structure. A rotating cap is fixedly installed at the bottom end of the external threaded rod. A longitudinal telescopic rod penetrating the rod body through hole is fixedly installed on the upper surface of the upper limit plate. The top end of the longitudinal telescopic rod is installed inside the shaft body installation groove through a bearing.

[0011] Preferably, the threaded structure includes an internal threaded structure provided in the internal threaded hole and an external threaded structure provided on the rod body of the external threaded rod, and the internal threaded structure matches the external threaded structure.

[0012] Compared with the prior art, the present invention provides a molecular biology sample grinding device, which has the following beneficial effects: It can generate elastic grinding pressure on biological samples, and this pressure is adjustable, so that the staff can adjust the grinding pressure according to the pressure received by different samples. In addition, the device can realize a grinding path from the inside to the outside, so that a one-time grinding effect on biological samples can be achieved to improve the grinding efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 is a three-dimensional view of the present invention; Figure 2 is a three-dimensional sectional view of the present invention; Figure 3 is a three-dimensional view of the screw feeding type grinding mechanism in the present invention; Figure 4 is a three-dimensional sectional view of the screw feeding type grinding mechanism in the present invention; Figure 5 is a three-dimensional view of the grinding pressure adjusting mechanism in the present invention; Figure 6 This is a three-dimensional sectional view of the grinding pressure adjusting mechanism in the present invention.

[0014] Wherein: 1. Bottom support base; 2. First support rod; 3. First fixed substrate; 4. First component installation port; 5. Second support rod; 6. Second fixed substrate; 7. Second component installation port; 8. Third support rod; 9. Third fixed substrate; 10. Screw feeding type grinding mechanism; 101. Motor fixed seat; 102. Driving motor; 103. Rotor; 104. Coupling; 105. Upper grinding disc; 106. Lower grinding disc; 107. Material storage housing; 108. Funnel-shaped cavity; 109. Material conveying cavity; 1010. Shaft body installation groove; 1011. Screw; 11. Grinding pressure adjusting mechanism; 111. Longitudinal hollow housing; 112. Longitudinal component moving cavity; 113. Internal thread hole; 114. Rod body perforation; 115. Lower limit plate; 116. Upper limit plate; 117. External threaded rod; 118. Rotating cap; 119. Helical spring; 1110. Longitudinal telescopic rod; 12. Rotor perforation. Specific embodiments

[0015] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0016] Please refer to Figure 1 and Figure 2 A molecular biology sample grinding device includes a bottom support base 1, a first fixed substrate 3 fixedly installed above the bottom support base 1 through a first support rod 2, a first component installation port 4 provided at the center of the first fixed substrate, a second fixed substrate 6 fixedly installed on the upper surface of the bottom support base 1 and directly above the first fixed substrate 3 through a second support rod 5, a second component installation port 7 provided at the center of the second fixed substrate 6, a third fixed substrate 9 fixedly installed directly above the second fixed substrate 6 through a third support rod 8, and a rotor perforation 12 provided at the center of the third fixed substrate 9.

[0017] In order to achieve multi-functional use of a single machine and thus improve the effective utilization rate of the kinetic energy of the driving motor 102, please refer to Figure 1 、 Figure 2 、 Figure 3 and Figure 4, it is necessary to set up a screw-feeding grinding mechanism 10, which is internally provided with an upper grinding disc 105 and a lower grinding disc 106 that can grind molecular samples during relative rotation, a material storage housing 107 that is arranged on the upper surface of the upper grinding disc 105 and fixedly installed in the second component mounting port 7 and can pre-store sample materials, a driving motor 102 fixedly installed on the upper surface of the third fixed substrate 9, and a screw 1011 that is placed in the material storage housing 107 and can rotate with the rotor 103 of the driving motor 102 and drive the samples inside the material storage housing 107 to achieve a downward conveying effect. The molecular material is put into the interior of the material storage housing 107. Under the action of gravity, the molecular material will enter the material conveying cavity 109. The driving motor 102 is started, and the rotor 103 will drive the screw 1011 to rotate. At this time, the material around the screw 1011 will move downward. When the pressure of the downward movement of the material is greater than the elastic strength of the helical spring 119, the material will be pressed between the upper grinding disc 105 and the lower grinding disc 106. The rotating lower grinding disc 106 will make the material move from the center to the outside, and a friction grinding effect will be achieved during the movement process, so that the kinetic energy of the driving motor 102 can not only achieve the pressure conveying of the material, but also achieve the grinding effect on the molecular sample, thereby improving the effective utilization rate of the kinetic energy of the driving motor 102.

[0018] For the specific structure of the screw-feeding grinding mechanism 10, please refer to Figure 3 and Figure 4 , including a motor fixing seat 101 fixedly installed on the upper surface of the third fixed substrate 9, an upper grinding disc 105 and a lower grinding disc 106 symmetrically arranged up and down. The driving motor 102 in an inverted state is fixedly installed inside the motor fixing seat 101. The rotor 103 of the driving motor 102 penetrates through the motor fixing seat 101 and the rotor perforation 12. An axially installed groove 1010 with an inward concave structure is arranged at the center of the bottom end of the lower grinding disc 106. A material storage housing 107 with an integral structure is arranged on the upper surface of the upper grinding disc 105. A funnel-shaped cavity 108 with an open top is arranged in the top area of the material storage housing 107. A material conveying cavity 109 with an open bottom end and a top end communicating with the bottom end of the funnel-shaped cavity 108 is arranged in the bottom area of the material storage housing 107 and the interior of the upper grinding disc 105. The bottom end of the rotor 103 is installed with a screw 1011 located inside the funnel-shaped cavity 108 and the material conveying cavity 109 through a coupling 104. The structural radius of the upper port of the funnel-shaped cavity 108 is greater than that of its lower port, and the structural radius of the lower port of the funnel-shaped cavity 108 is the same as the structural radius of the material conveying cavity 109. After the driving motor 102 is started, the rotation of the screw 1011 makes the material around it generate a downward conveying direction.

[0019] To achieve the function of adjusting the grinding pressure, please refer to Figure 1 , Figure 2 , Figure 5 and Figure 6 , it is necessary to set up a grinding pressure adjusting mechanism 11, which internally has a longitudinal hollow housing 111 fixedly installed in the first component mounting port 4 and hollow inside, a helical spring 119 placed inside the longitudinal hollow housing 111 and in a compressed state, a longitudinal telescopic rod 1110 that can exert an upward elastic force on the lower grinding disc 106, and an external threaded rod 117 that can change the elastic pressure of the helical spring 119. By rotating the rotating cap 118, due to the connection relationship of the threaded structure, the external threaded rod 117 will drive the lower grinding disc 106 to move longitudinally, thereby changing the distance between the lower limit plate 115 and the upper limit plate 116, and further changing the elastic strength of the helical spring 119 during operation. Finally, the pressure between the upper grinding disc 105 and the lower grinding disc 106 during grinding will be changed, achieving the function of adjusting the grinding pressure.

[0020] Regarding the specific structure of the grinding pressure adjusting mechanism 11, please refer to Figure 5 and Figure 6 , including a longitudinal hollow housing 111 fixedly installed in the first component mounting port 4. The interior of the longitudinal hollow housing 111 is provided with a longitudinal component activity cavity 112. The bottom end of the longitudinal hollow housing 111 is provided with an internal threaded hole 113 communicating with the bottom end of the longitudinal component activity cavity 112. The top end of the longitudinal hollow housing 111 is provided with a rod body perforation 114 communicating with the top end of the longitudinal component activity cavity 112. Inside the longitudinal hollow housing 111 and located within the longitudinal component activity cavity 112, there are placed a lower limit plate 115 and an upper limit plate 116 that can move axially along the longitudinal component activity cavity 112. A compressed helical spring 119 is placed between the lower limit plate 115 and the upper limit plate 116. The bottom end of the lower limit plate 115 is installed with a rotatable external threaded rod 117 through a bearing. The rod body of the external threaded rod 117 is installed in the internal threaded hole 113 through a threaded structure. The bottom end of the external threaded rod 117 is fixedly installed with a rotating cap 118. The upper surface of the upper limit plate 116 is fixedly installed with a longitudinal telescopic rod 1110 passing through the rod body perforation 114. The top end of the longitudinal telescopic rod 1110 is installed inside the shaft body installation groove 1010 through a bearing. The threaded structure includes an internal threaded structure provided in the internal threaded hole 113 and an external threaded structure provided on the rod body of the external threaded rod 117, and the internal threaded structure matches the external threaded structure.

[0021] In use, according to the hardness of the molecular sample, the rotating cap 118 is rotated. Due to the connection relationship of the threaded structure, the outer threaded rod 117 will drive the lower grinding disc 106 to move longitudinally, and finally the pressure between the upper grinding disc 105 and the lower grinding disc 106 during grinding will be changed, so that the pressure is sufficient to grind the molecular sample into powder. The molecular material is put into the interior of the material storage housing 107. Under the action of gravity, the molecular material will enter the material conveying cavity 109. The driving motor 102 is started, and the rotor 103 will drive the screw 1011 to rotate. At this time, the material located around the screw 1011 will move downward. When the pressure of the downward movement of the material is greater than the elastic strength of the helical spring 119, the material will be pressed between the upper grinding disc 105 and the lower grinding disc 106. The rotating lower grinding disc 106 will cause the material to move from the center to the outside, and a frictional grinding effect will be achieved during the movement process.

[0022] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A molecular biology sample grinding device, comprising a bottom support base (1), a No. 1 fixed base plate (3) fixedly mounted on the top of the bottom support base (1) via a No. 1 support rod (2), a No. 1 component mounting opening (4) arranged at the center of the No. 1 fixed base plate (6), a No. 2 fixed base plate (6) fixedly mounted on the upper surface of the bottom support base (1) via a No. 2 support rod (5) and located directly above the No. 1 fixed base plate (3), a No. 2 component mounting opening (7) arranged at the center of the No. 2 fixed base plate (6), a No. 3 fixed base plate (9) fixedly mounted directly above the No. 2 fixed base plate (6) via a No. 3 support rod (8), and a rotor through hole (12) arranged at the center of the No. 3 fixed base plate (9), characterized in that: Also includes, A screw feeding type grinding mechanism (10) is provided with an upper grinding disc (105) and a lower grinding disc (106) capable of grinding a molecular sample when rotating relative to each other, a material storage shell (107) disposed on the upper surface of the upper grinding disc (105) and fixedly mounted in a second component mounting opening (7) and capable of pre-storing sample materials, a driving motor (102) fixedly mounted on the upper surface of a third fixed base plate (9), and a screw (1011) disposed in the material storage shell (107) and capable of rotating with a rotor (103) of the driving motor (102) and driving the sample located in the material storage shell (107) to achieve a downward conveying effect; and a grinding pressure regulating mechanism (11), which is provided with a longitudinal hollow shell (111) fixedly mounted in the first component mounting opening (4) and having a hollow interior, a coil spring (119) placed in the longitudinal hollow shell (111) and in a compressed state, a longitudinal telescopic rod (1110) capable of exerting an upward elastic force on the lower grinding disc (106), and an externally threaded rod (117) capable of changing the elastic pressure of the coil spring (119).

2. A molecular biology sample grinding device according to claim 1, characterized in that: The screw feeding type grinding mechanism (10) comprises a motor fixing seat (101) fixedly mounted on the upper surface of a third fixed base plate (9), an upper grinding disc (105) and a lower grinding disc (106) symmetrically arranged at the upper and lower sides, an inverted driving motor (102) fixedly mounted inside the motor fixing seat (101), a rotor (103) of the driving motor (102) passing through the motor fixing seat (101) and the rotor through hole (12), a shaft body mounting groove (1010) of an inner concave structure is arranged at the center of the bottom end of the lower grinding disc (106), and the upper grinding disc (105) is fixedly mounted on the inner side of the motor fixing seat (101). ) is provided on the upper surface of the rotor (103) with a material storage shell (107) of an integral structure therewith, the top region of the material storage shell (107) is provided with a funnel-shaped cavity (108) with an open top, the bottom region of the material storage shell (107) and the interior of the upper grinding disc (105) are provided with a material conveying cavity (109) with an open bottom and a top connected to the bottom of the funnel-shaped cavity (108), and the bottom end of the rotor (103) is provided with a screw (1011) located inside the funnel-shaped cavity (108) and the material conveying cavity (109) via a coupling (104).

3. A molecular biology sample grinding device according to claim 2, characterized in that: The structural radius of the upper port of the funnel-shaped cavity (108) is greater than the structural radius of the lower port thereof, and the structural radius of the lower port of the funnel-shaped cavity (108) is the same as the structural radius of the material conveying cavity (109).

4. A molecular biology sample grinding device according to claim 3, characterized in that: After the driving motor (102) is started, the screw (1011) rotates so that the material around it is conveyed in a downward direction.

5. A molecular biology sample grinding device according to claim 4, characterized in that: The grinding pressure regulating mechanism (11) comprises a longitudinal hollow shell (111) fixedly mounted in the first component mounting port (4); a longitudinal component movable cavity (112) is arranged inside the longitudinal hollow shell (111); an internal threaded hole (113) connected to the bottom end of the longitudinal component movable cavity (112) is arranged at the bottom end of the longitudinal hollow shell (111); a rod body through hole (114) connected to the top end of the longitudinal component movable cavity (112) is arranged at the top end of the longitudinal hollow shell (111); and a lower limit plate (115) capable of axial movement along the longitudinal component movable cavity (112) is arranged inside the longitudinal component movable cavity (112) of the longitudinal hollow shell (111). and an upper limit plate (116), a helical spring (119) in a compressed state is arranged between the lower limit plate (115) and the upper limit plate (116), a rotatable externally threaded rod (117) is mounted on the bottom end of the lower limit plate (115) via a bearing, the rod body of the externally threaded rod (117) is mounted in the internally threaded hole (113) via a threaded structure, a rotating cap (118) is fixedly mounted on the bottom end of the externally threaded rod (117), a longitudinal telescopic rod (1110) penetrating the rod body through-hole (114) is fixedly mounted on the upper surface of the upper limit plate (116), and the top end of the longitudinal telescopic rod (1110) is mounted inside the shaft body mounting groove (1010) via a bearing.

6. A molecular biology sample grinding device according to claim 5, characterized in that: The thread structure comprises an internal thread structure arranged in the internal thread hole (113) and an external thread structure arranged on the rod body of the external thread rod (117), and the internal thread structure matches the external thread structure.

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