Multifunctional sampling device

Abstract

The invention relates to a multifunctional sampling device which comprises a first rod part, a second rod part, a first sampling part and a second sampling part, the first sampling part is located at the first end of the first rod part, and the second sampling part is located at the first end of the second rod part; the first rod part and the second rod part are locally connected, and the distance from the first end of the first sampling part to the first end of the second rod part is adjustable; when the distance between the first end of the first rod part and the first end of the second rod part is minimum, the first edge of the first sampling part is attached to the first edge of the second sampling part, so that the first sampling part and the second sampling part are combined to form an accommodating part; a cutting part is arranged on the first edge of the first sampling part and / or the first edge of the second sampling part. In the sampling process of the multifunctional sampling device, a sample does not need to pass through a narrow suction nozzle and is not extruded, and the original sample can be better kept. Therefore, the multifunctional sampling device provided by the invention is suitable for sampling tissues and organoid, and can realize less redundant residual quantity and keep the tissue structure undamaged.

Description

Technical Field

[0001] The present invention relates to the technical field of biological experimental instruments, and particularly to a multi-functional sampling device. Background Art

[0002] In recent years, the number of literatures related to organoid research has shown a linear upward trend. Organoids refer to tissue analogs with a certain spatial structure formed by in vitro three-dimensional culture of adult stem cells or pluripotent stem cells. Although organoids are not real human organs, they can simulate the in vivo tissue structure and function to the greatest extent and can be passaged and cultured stably for a long time. Currently, various organoids of internal organs have been successfully constructed, including the small intestine, stomach, colon, lung, bladder, brain, liver, pancreas, kidney, ovary, esophagus, heart, etc., including not only organoids of normal organ tissues but also organoids of corresponding tumor tissues.

[0003] Since organoids are tissue analogs with a certain spatial structure, during the sampling process, if a pipette or micropipette is used, it is not only easy to retain the components of the culture medium, but also easy to be squeezed when passing through the narrow nozzle position, thus damaging the tissue structure and causing losses. Therefore, there is an urgent need to propose a multi-functional sampling device suitable for tissues and organoids. Summary of the Invention

[0004] In view of this, the present invention provides a multi-functional sampling device, which can overcome the technical defects of the prior art and is suitable for multi-functional operations on tissues and organoids.

[0005] The multi-functional sampling device proposed by the present invention includes a first rod portion, a second rod portion, a first sampling portion, and a second sampling portion, wherein: the first sampling portion is located at the first end of the first rod portion, and the second sampling portion is located at the first end of the second rod portion; the first rod portion and the second rod portion are locally connected, and the distance from the first end of the first sampling portion to the first end of the second rod portion is adjustable; when the distance between the first end of the first rod portion and the first end of the second rod portion is the smallest, the first edge of the first sampling portion fits with the first edge of the second sampling portion, so that the first sampling portion and the second sampling portion are combined to form a receiving portion; a cutting portion is provided on the first edge of the first sampling portion and / or the first edge of the second sampling portion.

[0006] Optionally, the first sampling portion and / or the second sampling portion has a plurality of filter holes.

[0007] Optionally, the midpoints of the first rod portion and the second rod portion are connected by a rotating shaft so that the first rod portion and the second rod portion are in an X shape.

[0008] Optionally, the second end of the first rod portion and / or the second end of the second rod portion has a concave surface to form an auxiliary receiving space.

[0009] Optionally, the second ends of the first rod portion and the second rod portion are connected so that the first rod portion and the second rod portion form a V shape.

[0010] Optionally, the accommodating portion is in the shape of a hemispherical shell or a semi-ellipsoidal shell.

[0011] Optionally, the first sampling portion and the second sampling portion have the same shape.

[0012] Optionally, the cutting portion is in the shape of a thin blade or a serrated shape.

[0013] Optionally, both the first rod portion and the second rod portion are telescopic rods.

[0014] Optionally, the materials of the first sampling portion and the second sampling portion are both medical plastics or medical stainless steels.

[0015] According to the technical solution of the present invention, since the cutting portion is provided on the first sampling portion and / or the second sampling portion, a sample can be cut out from the culture material; since the distance from the first end of the first rod portion to the first end of the second rod portion can be adjusted to be minimized, the first sampling portion and the second sampling portion are in partial contact with each other and form an accommodating space in combination, and the cut-out sample falls into the accommodating space, and the sample can be safely transferred later. During the sampling process of the multifunctional sampling device, the sample does not need to pass through a narrow nozzle and will not be squeezed, and can better maintain its original state. Therefore, the multifunctional sampling device of the present invention is suitable for tissue and organoid sampling, and can achieve less redundant residue and keep the tissue structure intact. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] For purposes of illustration and not limitation, the present invention will now be described in accordance with preferred embodiments of the present invention, particularly with reference to the accompanying drawings, in which:

[0017] Figure 1A is a top view of the multifunctional sampling device of the first embodiment;

[0018] Figure 1B is a front view of the multifunctional sampling device of the first embodiment;

[0019] Figure 1C is a side view of the multifunctional sampling device of the first embodiment;

[0020] Figure 1D is a first three-dimensional schematic diagram of the multifunctional sampling device of the first embodiment;

[0021] Figure 1E is a second three-dimensional schematic diagram of the multifunctional sampling device of the first embodiment;

[0022] Figure 2A is a first three-dimensional schematic diagram of the multifunctional sampling device of the second embodiment;

[0023] Figure 2B The second three-dimensional schematic diagram of the multi-functional sampling device of the second embodiment;

[0024] Figure 3 The three-dimensional schematic diagram of the multi-functional sampling device of the third embodiment;

[0025] Figure 4 The three-dimensional schematic diagram of the multi-functional sampling device of the fourth embodiment.

[0026] In the figure:

[0027] 01. The multi-functional sampling device of the first embodiment; 02. The multi-functional sampling device of the second embodiment; 03. The multi-functional sampling device of the third embodiment; 04. The multi-functional sampling device of the fourth embodiment; 10. The first rod part; 20. The second rod part; 30. The first sampling part; 40. The second sampling part; 50. The filtering hole; 60. The cutting part; 70. The concave surface. Specific embodiments

[0028] The following describes exemplary embodiments of the present invention with reference to the accompanying drawings. Various details of the embodiments of the present invention are included to assist in understanding, and they should be considered merely exemplary. Therefore, those of ordinary skill in the art should recognize that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of the present invention. Similarly, for the sake of clarity and conciseness, descriptions of well-known functions and structures are omitted in the following description.

[0029] The multi-functional sampling device according to the embodiment of the present invention mainly includes a first rod part, a second rod part, a first sampling part, and a second sampling part. The first sampling part is located at the first end of the first rod part, and the second sampling part is located at the first end of the second rod part. The first rod part and the second rod part are locally connected, and the distance from the first end of the first sampling part to the first end of the second rod part is adjustable. When the distance between the first end of the first rod part and the first end of the second rod part is the smallest, the first edge of the first sampling part fits with the first edge of the second sampling part, so that the first sampling part and the second sampling part are combined to form a receiving part. The first edge of the first sampling part and / or the first edge of the second sampling part is provided with a cutting part.

[0030] According to the technical solution of the present invention, since the cutting part is provided on the first sampling part and / or the second sampling part, a sample can be cut out from the culture material. Since the distance from the first end of the first rod part to the first end of the second rod part can be adjusted to be the minimum, the first sampling part and the second sampling part are in partial contact with each other and form an accommodation space together, and the cut-out sample falls into the accommodation space, and then the sample can be safely transferred. During the complete sampling process, the sample does not need to pass through a narrow nozzle and will not be squeezed, and can better maintain its original state. Therefore, the multi-functional sampling device of the present invention is suitable for tissue and organoid sampling, and can achieve less redundant residue and keep the tissue structure intact.

[0031] In the multi-functional sampling device according to an embodiment of the present invention, the first sampling part and / or the second sampling part may have a plurality of filter holes, which can filter out excess culture solution. The plurality of filter holes can be circular holes or rectangular holes, and the average pore diameter can be flexibly set according to requirements.

[0032] The accommodating part can be in the shape of a hemispherical shell or a semi-ellipsoidal shell, and this design can accommodate more samples.

[0033] The cutting part can be in the shape of a thin blade or a serrated shape, and this design can effectively cut and sample.

[0034] The first sampling part and the second sampling part have the same shape, and this design can enable the same mold to be used when manufacturing the first sampling part and the second sampling part, saving manufacturing costs.

[0035] The first rod part and the second rod part can also be set as telescopic rods, so that the total length of the multi-functional sampling device can be flexibly adjusted to be suitable for different experimental occasions. The materials of the first sampling part and the second sampling part can both be medical plastics (such as polystyrene) or medical stainless steel, which have the advantages of being clean, hygienic and easy to sterilize.

[0036] In order to enable those skilled in the art to better understand, four embodiments are listed below for illustration.

[0037] Embodiment 1

[0038] The multi-functional sampling device 01 according to the embodiment of the present invention is as Figures 1A to 1E shown, and includes a first rod part 10, a second rod part 20, a first sampling part 30 and a second sampling part 40. The first sampling part 30 is located at the first end of the first rod part 10, and the second sampling part 40 is located at the first end of the second rod part 20. The first rod part 10 and the second rod part 20 are locally connected. Specifically, the midpoints of the first rod part 10 and the second rod part 20 are connected by a rotating shaft so that the first rod part 10 and the second rod part 20 are in an X shape, so that the user can complete sampling by using a "pinching" action. Figure 1D is a three-dimensional schematic diagram of the multi-functional sampling device 01 in the clamped state; Figure 1ESchematic perspective view of the multi-functional sampling device 01 in the open state. The second end of the first rod portion 10 and / or the second end of the second rod portion 20 may have a concave surface 70 to form an auxiliary accommodation space. The concave surface 70 may specifically be a groove shape as shown in the figure, and may also be a spoon shape or other shapes in other embodiments. The distance from the first end of the first sampling portion 10 to the first end of the second rod portion 20 is adjustable, that is, the distance between the first sampling portion 30 and the second sampling portion 40 is adjustable. When the distance between the first end of the first rod portion 10 and the first end of the second rod portion 20 is the smallest, the first edge of the first sampling portion 30 fits with the first edge of the second sampling portion 40, that is, the two are aligned and in partial contact with each other. In this way, the first sampling portion 30 and the second sampling portion 40 can be combined to form an accommodation portion, and the accommodation portion is hemispherical. In the multi-functional sampling device 01, a plurality of filter holes 50 are provided only on the first sampling portion 30. Cutting portions 60 are provided on both the first edge of the first sampling portion 30 and the first edge of the second sampling portion 40.

[0039] Embodiment 2

[0040] The multi-functional sampling device 02 of the embodiment of the present invention is as Figures 2A to 2B shown. The difference between the multi-functional sampling device 02 and the multi-functional sampling device 01 is that a plurality of filter holes 50 are provided on both the first sampling portion 30 and the second sampling portion 40.

[0041] Embodiment 3

[0042] The multi-functional sampling device 03 of the embodiment of the present invention is as Figure 3 shown, and includes a first rod portion 10, a second rod portion 20, a first sampling portion 30, and a second sampling portion 40. The first sampling portion 30 is located at the first end of the first rod portion 10, and the second sampling portion 40 is located at the first end of the second rod portion 20. The first rod portion 10 and the second rod portion 20 are partially connected. Specifically, the second end of the first rod portion 10 and the second end of the second rod portion 20 are connected so that the first rod portion 10 and the second rod portion 20 are in a V shape, so that the user can complete the sampling by using a "pinching" action. The distance from the first end of the first rod portion 10 to the first end of the second rod portion 20 is adjustable, that is, the distance between the first sampling portion 30 and the second sampling portion 40 is adjustable. When the distance between the first end of the first rod portion 10 and the first end of the second rod portion 20 is the smallest, the first edge of the first sampling portion 30 fits with the first edge of the second sampling portion 40, that is, the two are aligned and in partial contact with each other. In this way, the first sampling portion 30 and the second sampling portion 40 can be combined to form an accommodation portion, and the accommodation portion is hemispherical. In the multi-functional sampling device 01, a plurality of filter holes 50 are provided only on the first sampling portion 30. Cutting portions 60 are provided on both the first edge of the first sampling portion 30 and the first edge of the second sampling portion 40.

[0043] Embodiment 4

[0044] The multi-functional sampling device 04 of the embodiment of the present invention is asFigure 4 As shown, the difference between the multifunctional sampling device 02 and the multifunctional sampling device 03 is that a plurality of filter holes 50 are provided on both the first sampling part 30 and the second sampling part 40.

[0045] The above specific embodiments do not constitute a limitation on the protection scope of the present invention. Those skilled in the art should understand that various modifications, combinations, sub - combinations and substitutions can occur depending on design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A multi-functional sampling device, characterized in that, It includes a first rod portion, a second rod portion, a first sampling portion, and a second sampling portion, wherein: The first sampling portion is located at the first end of the first rod portion, and the second sampling portion is located at the first end of the second rod portion; The first rod portion and the second rod portion are partially connected, and the distance from the first end of the first sampling portion to the first end of the second rod portion is adjustable; When the distance between the first end of the first rod portion and the first end of the second rod portion is the smallest, the first edge of the first sampling portion fits with the first edge of the second sampling portion, so that the first sampling portion and the second sampling portion are combined to form a receiving portion; A cutting portion is provided on the first edge of the first sampling portion and / or the first edge of the second sampling portion.

2. The multi-functional sampling device according to claim 1, characterized in that, The first sampling portion and / or the second sampling portion has a plurality of filter holes.

3. The multi-functional sampling device according to claim 1, characterized in that, The midpoints of the first rod portion and the second rod portion are connected by a rotating shaft so that the first rod portion and the second rod portion are in an X shape.

4. The multi-functional sampling device according to claim 3, characterized in that, The second end of the first rod portion and / or the second end of the second rod portion has a concave surface to form an auxiliary receiving space.

5. The multi-functional sampling device according to claim 1, characterized in that, The second end of the first rod portion is connected to the second end of the second rod portion so that the first rod portion and the second rod portion are in a V shape.

6. The multi-functional sampling device according to claim 1, characterized in that, The receiving portion is in the shape of a hemispherical shell or a semi-elliptical shell.

7. The multi-functional sampling device according to claim 1, characterized in that, The first sampling portion and the second sampling portion have the same shape.

8. The multi-functional sampling device according to claim 1, characterized in that, The cutting portion is in the shape of a thin blade or a serrated shape.

9. The multi-functional sampling device according to claim 1, characterized in that, Both the first rod portion and the second rod portion are telescopic rods.

10. The multi-functional sampling device according to any one of claims 1 to 9, characterized in that, The materials of the first sampling portion and the second sampling portion are both medical plastics or medical stainless steels.

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