Oxytetracycline hydrochloride crystallization device and working method thereof

Abstract

The invention belongs to the technical field of separation, and particularly relates to an oxytetracycline hydrochloride crystallization device and a working method thereof.The oxytetracycline hydrochloride crystallization device is characterized in that a feeding mechanism is arranged on a crystallization mechanism and communicates with the crystallization mechanism, and raw materials enter the crystallization mechanism through the feeding mechanism and then are crystallized in the crystallization mechanism; a plurality of feeding runners are arranged in the feeding mechanism, and filter bags are arranged in the feeding runners; a cleaning mechanism is arranged outside the feeding mechanism and comprises cleaning assemblies corresponding to the filter bags, air outlets of the cleaning assemblies are located above the inner bottom faces of the corresponding filter bags, and the cleaning assemblies are suitable for blowing impurities on the inner bottom faces of the filter bags and preventing the air outlets of the cleaning assemblies from being blocked. Therefore, the situation that the gas output and the gas output range are affected due to the fact that the inner diameter of the inner pipeline is reduced or blocked is avoided.

Description

Technical Field

[0001] The present invention belongs to the technical field of general chemical apparatuses, specifically relates to the technical field of separation, and particularly relates to a crystallization apparatus for oxytetracycline hydrochloride and its working method. Background Art

[0002] During the preparation of oxytetracycline hydrochloride, crystallization needs to be precipitated first and then dried. However, when the raw materials are input into the crystallization mechanism, the impurities in the raw materials will block the filtering mechanism, resulting in unsmooth flow of the raw materials, increasing the crystallization time and decreasing the crystallization efficiency.

[0003] Therefore, due to the technical problem that the crystallization efficiency is decreased because the filtering mechanism is blocked during the input of raw materials, a crystallization apparatus for oxytetracycline hydrochloride and its working method need to be designed.

[0004] It should be noted that the above information disclosed in this background art part is only used to understand the background art of the concept of this application. Therefore, the above description is not considered as information of the prior art. Summary of the Invention

[0005] The embodiments of the present disclosure at least provide a crystallization apparatus for oxytetracycline hydrochloride and its working method.

[0006] In a first aspect, the embodiments of the present disclosure provide a crystallization apparatus for oxytetracycline hydrochloride, including: a crystallization mechanism and a feeding mechanism; The feeding mechanism is arranged on the crystallization mechanism, and the feeding mechanism is communicated with the crystallization mechanism. After the raw materials enter the crystallization mechanism through the feeding mechanism, they are crystallized in the crystallization mechanism; A plurality of feeding channels are arranged in the feeding mechanism. The feeding channels are communicated with the crystallization mechanism, and filter bags are arranged in the feeding channels; A cleaning mechanism is arranged outside the feeding mechanism, and the cleaning mechanism extends into the feeding mechanism. The cleaning mechanism includes a cleaning component corresponding to the filter bag. The air outlet of the cleaning component is located above the inner bottom surface of the corresponding filter bag. The inner diameter of the inner pipeline in the cleaning component is increased to avoid blocking of the air outlet of the inner pipeline.

[0007] In an optional embodiment, the cleaning mechanism includes: an air tank and a plurality of air pipes; The air tank is arranged outside the feeding mechanism, and gas is stored in the air tank; The air pipes are arranged on the air tank, and a part of the air pipes extends into the feeding mechanism; The air pipes are communicated with the air tank; The cleaning component is connected and communicated with the air pipes, and the cleaning component is located inside the feeding mechanism.

[0008] In an optional embodiment, the cleaning assembly includes: an inner pipe and an outer pipe disposed inside and outside; A chamber is formed between the inner pipe and the outer pipe, and the bottom surface of the chamber is in a sealed state, and the seal is close to the bottom end of the inner pipe; The vacuum pump is electrically connected to the control module, and the control module controls the vacuum pump to extract the gas in the chamber, so that the air pressure in the chamber decreases, thereby increasing the inner diameter of the inner pipe to avoid blockage of the inner pipe outlet.

[0009] In an optional embodiment, the bottom end of the inner pipe is an air outlet, and the air outlet is located above the inner bottom surface of the corresponding filter bag; The inner pipeline and the outer pipeline are both connected to the gas pipeline; The top of the inner pipe is in communication with a first air passage in the air delivery pipe, and the first air passage is in communication with the gas tank; The top of the chamber is in communication with a second air passage in the air delivery pipe, and the second air passage is connected to an air pump via an air extraction pipe; The inner pipe is made of a flexible material; The gas in the gas tank is blown toward the inner bottom surface of the filter bag through the inner pipe, blowing away the impurities on the inner bottom surface of the filter bag.

[0010] In an optional embodiment, a valve is provided between the gas tank and the gas pipeline, the valve is electrically connected to the control module, and the control module is configured to control the valve to open so as to introduce gas into the gas pipeline; The gas tank is provided with a gas replenishing port.

[0011] In an optional embodiment, the feeding mechanism includes: a sleeve; The sleeve is connected to the tank body in the crystallization mechanism; A plurality of feed channels are vertically arranged in the sleeve, and the bottom of the feed channels is connected to the tank body; A feed inlet is provided on the side wall of the sleeve, and the feed inlet is located above the top surface of the feed channel; A filter bag is arranged in the feed flow channel, and the air outlet of the cleaning component is located in the corresponding filter bag and above the inner bottom surface of the filter bag; The top surface of the sleeve is provided with a cover body.

[0012] In an optional embodiment, the crystallization mechanism includes: a tank body; The tank body is arranged horizontally, and a stirring mechanism is arranged in the tank body, and the stirring mechanism is suitable for stirring the raw materials entering the tank body; The tank body is provided with a heating mechanism, and the heating mechanism introduces hot air into the tank body to dry the crystals precipitated in the tank body.

[0013] In an alternative embodiment, the stirring mechanism includes: a stirring shaft and stirring blades; The stirring shaft is horizontally disposed through the tank body; The stirring blades are arranged on the stirring shaft; A driving motor is arranged outside the tank body, and the stirring shaft is connected to the driving motor; The driving motor is electrically connected to the control module, and the control module is configured to control the driving motor to drive the stirring shaft to rotate.

[0014] In an alternative embodiment, the heating mechanism includes: an air inlet joint and an air outlet joint; The air inlet joint and the air outlet joint are arranged on the outer wall of the tank body; Steam is introduced into the tank body through the air inlet joint, and the gas in the tank body is discharged through the air outlet joint; When the steam enters the inner pipe of the cleaning assembly, the air in the chamber between the inner pipe and the outer pipe of the cleaning assembly is pumped out by a suction pump, so that the steam condenses and adheres to the inner wall of the inner pipe, melting the crystals on the inner wall of the inner pipe and preventing the air outlet of the inner pipe from being blocked.

[0015] In an alternative embodiment, a liquid outlet is provided at the bottom of the tank body; A discharge port is provided on the tank body, and a baffle is provided on the discharge port.

[0016] In a second aspect, the embodiments of the present disclosure further provide a working method of using the above-mentioned crystallization device for oxytetracycline hydrochloride, including: After the raw materials enter the crystallization mechanism through the feeding mechanism, crystals are precipitated and dried in the crystallization mechanism; The impurities on the inner bottom surface of the filter bag are blown by the cleaning assembly, and the cleaning assembly prevents its own air outlet from being blocked.

[0017] The beneficial effect of the present invention is that the crystallization device for oxytetracycline hydrochloride of the present invention includes: a crystallization mechanism and a feeding mechanism; the feeding mechanism is arranged on the crystallization mechanism, and the feeding mechanism is communicated with the crystallization mechanism. After the raw materials enter the crystallization mechanism through the feeding mechanism, crystallization occurs in the crystallization mechanism; a plurality of feeding channels are arranged in the feeding mechanism, the feeding channels are communicated with the crystallization mechanism, and filter bags are arranged in the feeding channels; a cleaning mechanism is arranged outside the feeding mechanism, and the cleaning mechanism extends into the feeding mechanism. The cleaning mechanism includes a cleaning assembly corresponding to the filter bag. The air outlet of the cleaning assembly is located above the inner bottom surface of the corresponding filter bag. The inner diameter of the inner pipe in the cleaning assembly is increased to prevent the air outlet of the inner pipe from being blocked, thereby avoiding the situation that the air outlet volume and air outlet range are affected due to the reduction or blockage of the inner diameter of the inner pipe.

[0018] Other features and advantages of the present invention will be set forth in the following description, and in part will be obvious from the description, or may be learned by practice of the present invention. The objectives and other advantages of the present invention are realized and attained by the structure particularly pointed out in the specification and the drawings.

[0019] To make the above objectives, features and advantages of the present invention more comprehensible, specific preferred embodiments are presented herein, in conjunction with the accompanying drawings, and are described in detail as follows. Description of the Drawings

[0020] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0021] Figure 1 Schematic structural diagram of a crystal device for oxytetracycline hydrochloride provided by an embodiment of the present disclosure; Figure 2 Internal structural diagram of a feeding mechanism provided by an embodiment of the present disclosure; Figure 3 Cross-sectional view of a cleaning component provided by an embodiment of the present disclosure; Figure 4 Schematic structural diagram of a crystallization mechanism provided by an embodiment of the present disclosure; Figure 5 Cross-sectional view of a crystallization mechanism provided by an embodiment of the present disclosure; Figure 6 Principle block diagram of a crystal device for oxytetracycline hydrochloride provided by an embodiment of the present disclosure.

[0022] In the figures: 1 Crystallization mechanism, 11 Tank body, 12 Stirring mechanism, 121 Stirring shaft, 122 Stirring blades, 123 Driving motor, 13 Heating mechanism, 131 Air inlet joint, 132 Air outlet joint, 14 Liquid outlet, 15 Baffle; 2 Feeding mechanism, 21 Sleeve, 22 Feeding channel, 23 Feeding port, 24 Filter bag, 25 Cover body; 3 Cleaning mechanism, 31 Air tank, 32 Air delivery pipe, 321 First air passage, 322 Second air passage, 33 Cleaning component, 331 Inner pipe, 332 Outer pipe, 333 Chamber, 334 Air extraction pump, 335 Air extraction pipe, 34 Valve, 35 Air supply port. Detailed Embodiments

[0023] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Apparently, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of protection of the present invention.

[0024] In this document, when it is mentioned that the first component is located on the second component, this may mean that the first component can be directly formed on the second component, or a third component can be interposed between the first component and the second component. In addition, in the drawings, to effectively describe the technical content, the thickness of the components may be exaggerated or reduced.

[0025] As used herein, phrases such as "in one embodiment", "according to one embodiment", "in some embodiments", etc. generally refer to the fact that the specific features, structures, or characteristics after the phrase can be included in at least one embodiment of the present disclosure. Therefore, a specific feature, structure, or characteristic may be included in more than one embodiment of the present disclosure, such that these phrases do not necessarily refer to the same embodiment. As used herein, terms such as "example", "exemplary", etc. are used "as an example, instance, or illustration. Any embodiment, aspect, or design described herein as "example" or "exemplary" is not necessarily construed as being preferred or superior to other embodiments, aspects, or designs. On the contrary, the use of terms such as "example", "exemplary", etc. is intended to present concepts in a specific manner.

[0026] In the existing preparation process of oxytetracycline hydrochloride, liquid raw materials are filtered through a filter bag and then introduced into the tank of the crystallization mechanism. Then, by introducing a gas at an appropriate temperature into the tank, the solution reaches the crystallization temperature and is stirred for crystallization. After filtering out the liquid in the crystals, the remaining crystals are obtained. Then, hot air is introduced into the tank to dry the crystals. During the process of crystal precipitation of oxytetracycline hydrochloride, it is first necessary to introduce liquid raw materials into the crystallization mechanism. After the raw materials are filtered through the filter bag, they enter the crystallization mechanism. However, the inventor found that the filter bag would be blocked by impurities in the raw materials, resulting in the raw materials being unable to enter the crystallization mechanism or entering the crystallization mechanism very slowly, greatly increasing the time required for all the raw materials to complete crystal precipitation and affecting the crystallization efficiency. By blowing air, the impurities on the inner bottom surface of the filter bag can be blown away, enabling the raw materials to smoothly pass through the filter bag and enter the crystallization mechanism. However, the inventor also found that raw materials would enter the inner pipeline wall of the cleaning mechanism for blowing impurities due to splashing and other reasons, and crystals would precipitate on the inner pipeline wall, causing the inner pipeline to be blocked, resulting in the inability to blow air on the inner bottom surface of the filter bag and affecting the efficiency of the raw materials entering the crystallization mechanism.

[0027] Regarding the defects existing in the above solutions, they are all the results obtained by the inventor through practice and careful research. Therefore, the process of discovering the above problems and the solutions proposed in this disclosure by the present disclosure for the above problems should all be the contributions made by the inventor to the present disclosure during the process of the present disclosure.

[0028] It should be noted that similar reference numerals and letters represent similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0029] The following will, with reference to the drawings, elaborate on some embodiments of the present invention. Without conflict, the following embodiments and the features in the embodiments can be combined with each other.

[0030] As Figure 1 shown, at least one disclosed embodiment provides a crystallization device for oxytetracycline hydrochloride, including: a crystallization mechanism 1 and a feeding mechanism 2; the feeding mechanism 2 is arranged on the crystallization mechanism 1, the feeding mechanism 2 is communicated with the crystallization mechanism 1, and the raw material enters the crystallization mechanism 1 through the feeding mechanism 2 and crystallizes in the crystallization mechanism 1; a plurality of feeding channels 22 are arranged in the feeding mechanism 2, the feeding channels 22 are communicated with the crystallization mechanism 1, and filter bags 24 are arranged in the feeding channels 22; a cleaning mechanism 3 is arranged outside the feeding mechanism 2, and the cleaning mechanism 3 extends into the feeding mechanism 2, and the cleaning mechanism 3 includes a cleaning component 33 corresponding to the filter bag 24, the air outlet of the cleaning component 33 is located above the inner bottom surface of the corresponding filter bag 24, and the inner diameter of the inner pipeline 331 in the cleaning component 33 is increased to avoid the air outlet of the inner pipeline 331 being blocked, thereby avoiding the situation that the air outlet volume and the air outlet range are affected due to the reduction or blockage of the inner diameter of the inner pipeline 331.

[0031] In this embodiment, the cleaning component 33 is adapted to blow the impurities on the inner bottom surface of the filter bag 24, thereby realizing blowing the impurities on the inner bottom surface of the filter bag 24 during the process of filtering the raw material, avoiding the inner bottom surface of the filter bag 24 being blocked by impurities, ensuring that the raw material can pass through the filter bag 24, avoiding the situation that the raw material cannot enter the crystallization mechanism 1 due to the blockage of the filter bag 24, ensuring the speed of the raw material entering the crystallization mechanism 1, avoiding the increase of the crystallization precipitation time due to the increase of the time for the raw material to enter the crystallization mechanism, and ensuring the crystallization efficiency.

[0032] In this embodiment, the raw material is in a liquid state, and the raw material may adhere to the inner wall of the inner pipeline 331 due to reasons such as splashing. The raw material adhering to the inner pipeline 331 may precipitate crystals, resulting in the reduction or even blockage of the inner diameter of the inner pipeline 331. The reduction or blockage of the inner diameter of the inner pipeline 331 will affect the air outlet volume and the air outlet range, and further result in the inability to blow the impurities on the inner bottom surface of the filter bag 24.

[0033] AsFigure 2 As shown, in an alternative embodiment, the cleaning mechanism 3 includes: a gas tank 31 and a plurality of gas pipes 32; the gas tank 31 is arranged outside the feeding mechanism 2, and gas is stored in the gas tank 31; the gas pipes 32 are arranged on the gas tank 31, and part of the gas pipes 32 extends into the feeding mechanism 2; the gas pipes 32 are communicated with the gas tank 31; the cleaning component 33 is connected and communicated with the gas pipes 32, and the cleaning component 33 is located inside the feeding mechanism 2.

[0034] In this embodiment, high-pressure gas can be stored in the gas tank 31 so that the gas can be ejected from the cleaning component 33 after passing through the gas pipes 32.

[0035] As Figure 3 and Figure 6 As shown, in an alternative embodiment, the cleaning component 33 includes: an inner pipe 331 and an outer pipe 332; the outer pipe 332 is sleeved outside the inner pipe 331, and the bottom end of the inner pipe 331 is flush with the bottom end of the outer pipe 332; the bottom end of the inner pipe 331 is an air outlet, and the air outlet is located above the inner bottom surface of the corresponding filter bag 24; both the inner pipe 331 and the outer pipe 332 are connected to the gas pipes 32; the top of the inner pipe 331 is communicated with the first air passage 321 in the gas pipes 32, and the first air passage 321 is communicated with the gas tank 31; a chamber 333 is formed between the inner pipe 331 and the outer pipe 332, and the bottom surface of the chamber 333 is in a sealed state, and the seal is close to the bottom end of the inner pipe 331; the top of the chamber 333 is communicated with the second air passage 322 in the gas pipes 32, and the second air passage 322 is connected to an air extraction pump 334 through an air extraction pipe 335; the inner pipe 331 is made of a flexible material; the gas in the gas tank 31 is blown towards the inner bottom surface of the filter bag 24 through the inner pipe 331 to blow the impurities on the inner bottom surface of the filter bag 24; the air extraction pump 334 is electrically connected to a control module, and the control module controls the air extraction pump 334 to extract the gas in the chamber 333, so that the air pressure in the chamber 333 drops, and further the inner diameter of the inner pipe 331 increases to avoid blocking the air outlet of the inner pipe 331.

[0036] In this embodiment, gas can be ejected from the inner pipe 331 through the first air passage 321, and the gas comes from the gas tank 31.

[0037] In this embodiment, the bottom end of the inner pipe 331 being flush with the bottom end of the outer pipe 332 can better clean the crystals remaining on the inner wall of the inner pipe 331.

[0038] In this embodiment, when air is blown in the inner pipe 331, the direction of the air flow is as shown by F in the figure, and when the gas in the chamber 333 is extracted, the direction of the air flow is as shown by f in the figure.

[0039] In this embodiment, the gas in the chamber 333 can be pumped out through the second air duct 322, and gas can be replenished into the chamber 333. By separately arranging the first air duct 321 and the second air duct 322, the first air duct 321 and the second air duct 322 do not affect each other.

[0040] In this embodiment, the inner pipe 331 is made of a flexible material, so that the inner pipe 331 can be deformed to facilitate an increase in the inner diameter of the inner pipe 331. If crystals precipitate from the raw materials remaining on the inner wall of the inner pipe 331, the gas in the chamber 333 is pumped out, causing the air pressure in the chamber 333 to drop, making the outer wall of the inner pipe 331 approach the inner wall of the outer pipe 332. The inner pipe 331 deforms and its inner diameter becomes larger, ensuring that the gas outlet volume and outlet range of the inner pipe 331 are not affected by the precipitated crystals.

[0041] In this embodiment, when the raw materials enter the filter bag 24, air can be blown out through the inner pipe 331. By using the airflow to push the raw materials through the filter bag 24, the entry of the raw materials into the crystallization mechanism 1 can be accelerated, improving the crystallization efficiency. And if the impurities accumulated on the inner bottom surface of the filter bag 24 cause the inner bottom surface of the filter bag 24 to be blocked, the gas blown out by the inner pipe 331 can blow the impurities on the inner bottom surface of the filter bag 24. The impurities will accumulate towards the edge of the inner bottom surface of the filter bag 24, and the central area of the inner bottom surface of the filter bag 24 will be exposed without impurities, so that there is still an area without impurities on the inner bottom surface of the filter bag 24, preventing the filter bag 24 from being blocked and causing the raw materials to be unable to pass through the filter bag 24 and enter the crystallization mechanism 1.

[0042] In this embodiment, by pumping out the gas in the chamber 333, the area where the inner pipe 331 blows out gas is ensured, so as to ensure that a corresponding-sized impurity-free area can be blown out on the inner bottom surface of the filter bag 24, ensuring that the filter bag 24 will not be completely blocked by impurities and ensuring that the raw materials can enter the tank body 11 after passing through the filter bag 24.

[0043] In an alternative embodiment, a valve 34 is provided between the gas tank 31 and the gas pipeline 32. The valve 34 is electrically connected to the control module, and the control module is configured to control the valve 34 to open to introduce gas into the gas pipeline 32. A gas replenishment port 35 is provided on the gas tank 31.

[0044] In this embodiment, the valve 34 can be an electromagnetic valve or the like and is controlled by the control module. When the inner pipe 331 needs to blow out air, the control module controls the valve 34 to open, so that the gas in the gas tank 31 can be blown out through the inner pipe 331.

[0045] In this embodiment, gas can be replenished into the gas tank 31 through the gas replenishment port 35 to ensure that gas can be blown out from the inner pipe 331.

[0046] Such asFigure 2 As shown, in an alternative embodiment, the feeding mechanism 2 includes: a sleeve 21; the sleeve 21 is connected to the tank body 11 in the crystallization mechanism 1; several feeding channels 22 are vertically arranged in the sleeve 21, and the bottom of the feeding channels 22 communicates with the tank body 11; a feeding port 23 is formed in the side wall of the sleeve 21, and the feeding port 23 is located above the top surface of the feeding channels 22; a filter bag 24 is arranged in the feeding channels 22, and the air outlet of the cleaning assembly 33 is located inside the corresponding filter bag 24 and above the inner bottom surface of the filter bag 24; a cover body 25 is arranged on the top surface of the sleeve 21.

[0047] In this embodiment, air holes may be provided on the cover body 25 to facilitate the discharge of gas in the sleeve 21.

[0048] In this embodiment, the cover body 25 can prevent the raw materials entering the sleeve 21 from splashing out of the sleeve 21.

[0049] In this embodiment, by providing a plurality of feeding channels 22, the speed of raw materials entering the crystallization mechanism 1 can be increased.

[0050] As Figure 4 As shown, in an alternative embodiment, the crystallization mechanism 1 includes: a tank body 11; the tank body 11 is horizontally arranged, a stirring mechanism 12 is arranged inside the tank body 11, and the stirring mechanism 12 is adapted to stir the raw materials entering the tank body 11; a heating mechanism 13 is arranged on the tank body 11, and the heating mechanism 13 introduces hot air into the tank body 11 to dry the crystals precipitated in the tank body 11.

[0051] In this embodiment, the stirring mechanism 12 can stir the raw materials entering the tank body 11 to increase the speed of crystal precipitation.

[0052] In this embodiment, during the crystallization process, the control module repeatedly controls the operation of the air extraction pump 334. When the air extraction pump 334 operates, the gas in the chamber 333 is extracted, causing the inner diameter of the inner pipe 331 to increase. When the air extraction pump 334 does not operate, the external gas re-enters the chamber 333, causing the air pressure in the chamber 333 to recover and the inner diameter of the inner pipe 331 to decrease. Repeating this process causes the inner pipe 331 to deform repeatedly, shaking off the crystals precipitated on the inner wall of the inner pipe 331.

[0053] In this embodiment, after the crystallization is completed, the crystals are dried by introducing hot air into the tank body 11.

[0054] As Figure 5As shown, in an alternative embodiment, the stirring mechanism 12 includes a stirring shaft 121 and stirring blades 122; the stirring shaft 121 is horizontally disposed through the tank body 11; the stirring blades 122 are disposed on the stirring shaft 121; a driving motor 123 is disposed outside the tank body 11, and the stirring shaft 121 is connected to the driving motor 123; the driving motor 123 is electrically connected to the control module, and the control module is configured to control the driving motor 123 to drive the stirring shaft 121 to rotate.

[0055] As Figure 4 As shown, in an alternative embodiment, the heating mechanism 13 includes an air inlet joint 131 and an air outlet joint 132; the air inlet joint 131 and the air outlet joint 132 are disposed on the outer wall of the tank body 11; steam is introduced into the tank body 11 through the air inlet joint 131, and the gas in the tank body 11 is discharged through the air outlet joint 132; when the steam enters the inner pipe 331 of the cleaning assembly 33, the gas in the chamber 333 between the inner pipe 331 and the outer pipe 332 of the cleaning assembly 33 is pumped out by the air extraction pump 334, so that the steam condenses and adheres to the inner wall of the inner pipe 331, melting the crystals on the inner wall of the inner pipe 331 and preventing the air outlet of the inner pipe 331 from being blocked.

[0056] In this embodiment, the air inlet joint 131 can be connected to a steam generator, and the steam generated by the steam generator can enter the tank body 11.

[0057] In this embodiment, the air outlet joint 132 can be connected to an external pipe to facilitate the discharge of the gas in the tank body 11.

[0058] In this embodiment, the steam can be water vapor or the like.

[0059] In this embodiment, during the crystallization process, a gas at a suitable temperature can be introduced into the tank body 11 through the air inlet joint 131 to keep the temperature in the tank body 11 at the temperature required for crystallization.

[0060] In this embodiment, after the crystallization is completed, steam can be introduced into the tank body 11 to dry the crystals in the tank body 11.

[0061] In this embodiment, the air outlet joint 132 can ensure that the gas can be discharged from the air outlet joint 132 when the gas is introduced into the tank body 11, avoiding excessive pressure in the tank body 11.

[0062] In this embodiment, during the drying process, part of the steam enters the sleeve 21, then passes through the filter bag 24 and enters the inner pipe 331. At this time, the gas in the chamber 333 is repeatedly pumped out. After the gas in the chamber 333 is pumped out, the pressure in the chamber 333 drops, and the temperature in the chamber 333 decreases due to the drop in air pressure. At this time, when the steam contacts the inner wall of the inner pipe 331, it will condense and adhere to the inner wall of the inner pipe 331, redissolve the crystals that were originally precipitated and adhered to the inner wall of the inner pipe 331, and then drip off to remove the crystals on the inner wall of the inner pipe 331; after the air pump 334 pumps out the gas in the chamber 333, it stops pumping. At this time, the gas outside, which is cooler than the steam, will enter the chamber 333, reducing the temperature of the inner pipe 331, increasing the temperature difference between the inner pipe 331 and the steam, and enabling the steam contacting the inner pipe 331 to condense smoothly. The air pump 334 works and stops repeatedly, allowing the external air to enter the chamber 333 repeatedly, ensuring the condensation effect of the steam, and thus ensuring the effect of removing the precipitated crystals.

[0063] In an alternative embodiment, a liquid outlet 14 is provided at the bottom of the tank body 11; a discharge port is provided on the tank body 11, and a baffle 15 is provided on the discharge port.

[0064] In this embodiment, a filter screen can be provided in the liquid outlet 14. After crystallization is completed, the liquid outlet 14 is opened to discharge the remaining solution in the tank body 11, and the precipitated crystals are retained in the tank body 11.

[0065] In this embodiment, after drying is completed, the baffle 15 can be opened and the dried crystals can be taken out of the tank body 11.

[0066] At least one other disclosed embodiment also provides a working method of using the above-mentioned oxytetracycline hydrochloride crystallization device, including: after the raw material enters the crystallization mechanism 1 through the feeding mechanism 2, crystals are precipitated and dried in the crystallization mechanism 1; the cleaning component 33 blows the impurities on the inner bottom surface of the filter bag 24, and the cleaning component 33 prevents its own air outlet from being blocked.

[0067] In summary, the crystallization device for oxytetracycline hydrochloride includes a crystallization mechanism 1 and a feeding mechanism 2. The feeding mechanism 2 is arranged on the crystallization mechanism 1 and is in communication with the crystallization mechanism 1. After the raw material enters the crystallization mechanism 1 through the feeding mechanism 2, it crystallizes in the crystallization mechanism 1. A number of feeding channels 22 are provided in the feeding mechanism 2. The feeding channels 22 are in communication with the crystallization mechanism 1, and filter bags 24 are arranged in the feeding channels 22. A cleaning mechanism 3 is arranged outside the feeding mechanism 2 and extends into the feeding mechanism 2. The cleaning mechanism 3 includes a cleaning component 33 corresponding to the filter bag 24. The air outlet of the cleaning component 33 is located above the inner bottom surface of the corresponding filter bag 24. The cleaning component 33 is adapted to blow the impurities on the inner bottom surface of the filter bag 24, and the cleaning component 33 prevents its own air outlet from being blocked, avoiding the situation that the inner diameter of the inner pipeline 331 is reduced or blocked, which affects the air outlet volume and air outlet range. It also realizes blowing the impurities on the inner bottom surface of the filter bag 24 during the process of filtering the raw material, preventing the inner bottom surface of the filter bag 24 from being blocked by impurities, ensuring that the raw material can pass through the filter bag 24, avoiding the situation that the raw material cannot enter the crystallization mechanism 1 due to the blockage of the filter bag 24, ensuring the speed of the raw material entering the crystallization mechanism 1, avoiding the increase of the crystallization precipitation time, and ensuring the crystallization efficiency.

[0068] In the description of the embodiments of the present invention, unless otherwise clearly defined and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0069] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation to the present invention. In addition, terms such as "first", "second" and other numerical terms used in this text do not imply order or sequence unless clearly indicated in the text. Therefore, without departing from the teachings of the exemplary embodiments, the first element, component, region, layer or section discussed above can be referred to as the second element, component, region, layer or section.

[0070] Spatial relative terms, such as "inner", "outer", "below", "beneath", "lower", "above", "upper", etc., may be used herein to facilitate description of the relationship of one element or feature to another element or feature as illustrated in the figures. In addition to the orientation depicted in the figures, spatial relative terms are intended to encompass different orientations of the device in use or operation. For example, if the device in the figures is turned over, an element described as "below" or "beneath" another element or feature will be oriented "above" the other element or feature. Thus, the exemplary term "below" can encompass both an above and below orientation. The device may be otherwise oriented (rotated 90 degrees or at other orientations), and the spatial relative descriptors used herein are to be interpreted accordingly.

[0071] Inspired by the above-described ideal embodiments of the present invention, through the above description, relevant staff can make various changes and modifications completely within the scope not deviating from the technical idea of this invention. The technical scope of this invention is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A crystallization device for oxytetracycline hydrochloride, characterized in that: include: A crystallization mechanism (1) and a feeding mechanism (2); The feeding mechanism (2) is arranged on the crystallization mechanism (1), the feeding mechanism (2) is connected to the crystallization mechanism (1), and the raw material enters the crystallization mechanism (1) through the feeding mechanism (2) and then crystallizes in the crystallization mechanism (1); A plurality of feed channels (22) are provided in the feed mechanism (2), the feed channels (22) are in communication with the crystallization mechanism (1), and a filter bag (24) is provided in the feed channels (22); A cleaning mechanism (3) is arranged outside the feeding mechanism (2), and the cleaning mechanism (3) extends into the feeding mechanism (2); the cleaning mechanism (3) comprises a cleaning component (33) corresponding to the filter bag (24); an air outlet of the cleaning component (33) is located above the inner bottom surface of the corresponding filter bag (24); and the inner pipe (331) in the cleaning component (33) is increased in inner diameter to avoid clogging of the air outlet of the inner pipe (331).

2. The crystallization device of oxytetracycline hydrochloride according to claim 1, characterized in that: The cleaning mechanism (3) comprises: a gas tank (31) and a plurality of gas pipes (32); The gas tank (31) is arranged outside the feeding mechanism (2), and gas is stored in the gas tank (31); The gas delivery pipe (32) is arranged on the gas tank (31), and a portion of the gas delivery pipe (32) extends into the feeding mechanism (2); The gas delivery pipe (32) is in communication with the gas tank (31); The cleaning component (33) is connected to and communicates with the air delivery pipe (32), and the cleaning component (33) is located inside the feeding mechanism (2).

3. The crystallization device of oxytetracycline hydrochloride according to claim 2, characterized in that: The cleaning assembly (33) comprises: an inner pipe (331) and an outer pipe (332) which are arranged inside and outside; A chamber (333) is formed between the inner pipe (331) and the outer pipe (332), and the bottom surface of the chamber (333) is in a sealed state, with the seal close to the bottom end of the inner pipe (331); The vacuum pump (334) is electrically connected to a control module, and the control module controls the vacuum pump (334) to extract gas from the chamber (333), so that the air pressure in the chamber (333) decreases, thereby increasing the inner diameter of the inner pipe (331) to avoid clogging of the air outlet of the inner pipe (331).

4. The crystallization device of oxytetracycline hydrochloride according to claim 3, characterized in that: The bottom end of the inner pipe (331) is an air outlet, and the air outlet is located above the inner bottom surface of the corresponding filter bag (24); The inner pipe (331) and the outer pipe (332) are both connected to the gas transmission pipe (32); The top of the inner pipe (331) is in communication with a first air channel (321) in the air delivery pipe (32), and the first air channel (321) is in communication with the air tank (31); The top of the chamber (333) is in communication with the second air channel (322) in the air delivery pipe (32), and the second air channel (322) is connected to the air pump (334) via an air extraction pipe (335); The inner pipe (331) is made of a flexible material; The gas in the gas tank (31) is blown toward the inner bottom surface of the filter bag (24) through the inner pipe (331), thereby blowing away impurities on the inner bottom surface of the filter bag (24).

5. The crystallization device of oxytetracycline hydrochloride according to claim 2, characterized in that: A valve (34) is provided between the gas tank (31) and the gas pipeline (32), the valve (34) being electrically connected to a control module, the control module being configured to control the valve (34) to open so as to allow gas to flow into the gas pipeline (32); The gas tank (31) is provided with a gas replenishment port (35).

6. The crystallization device of oxytetracycline hydrochloride according to claim 1, characterized in that: The feeding mechanism (2) comprises: a sleeve (21); The sleeve (21) is connected to the tank body (11) in the crystallization mechanism (1); A plurality of feed channels (22) are vertically arranged in the sleeve (21), and the bottom of the feed channels (22) is connected to the tank body (11); A feed port (23) is provided on the side wall of the sleeve (21), and the feed port (23) is located above the top surface of the feed channel (22); A filter bag (24) is provided in the feed flow channel (22), and the air outlet of the cleaning component (33) is located in the corresponding filter bag (24) and above the inner bottom surface of the filter bag (24); A cover body (25) is provided on the top surface of the sleeve (21).

7. The crystallization device of oxytetracycline hydrochloride according to claim 1, characterized in that: The crystallization mechanism (1) comprises: a tank body (11); The tank body (11) is arranged horizontally, and a stirring mechanism (12) is arranged inside the tank body (11), wherein the stirring mechanism (12) is suitable for stirring the raw materials entering the tank body (11); The tank body (11) is provided with a heating mechanism (13), and the heating mechanism (13) introduces hot air into the tank body (11) to dry the crystals precipitated in the tank body (11); The bottom of the tank body (11) is provided with a liquid outlet (14); The tank body (11) is provided with a discharge port, and a baffle (15) is provided on the discharge port.

8. The crystallization device of oxytetracycline hydrochloride according to claim 7, characterized in that: The stirring mechanism (12) comprises: a stirring shaft (121) and a stirring blade (122); The stirring shaft (121) is transversely arranged in the tank body (11); The stirring blade (122) is arranged on the stirring shaft (121); A driving motor (123) is disposed outside the tank body (11), and the stirring shaft (121) is connected to the driving motor (123); The driving motor (123) is electrically connected to the control module, and the control module is configured to control the driving motor (123) to drive the stirring shaft (121) to rotate.

9. The crystallization device of oxytetracycline hydrochloride according to claim 7, characterized in that: The heating mechanism (13) comprises: an air inlet connector (131) and an air outlet connector (132); The air inlet connector (131) and the air outlet connector (132) are arranged on the outer wall of the tank body (11); Steam is introduced into the tank body (11) through the gas inlet joint (131), and gas in the tank body (11) is discharged through the gas outlet joint (132); When steam enters the inner pipe (331) in the cleaning component (33), the gas in the chamber (333) between the inner pipe (331) and the outer pipe (332) in the cleaning component (33) is extracted by the vacuum pump (334), so that the steam condenses and adheres to the inner wall of the inner pipe (331), melting the crystals on the inner wall of the inner pipe (331), thereby preventing the gas outlet of the inner pipe (331) from being blocked.

10. A working method using the oxytetracycline hydrochloride crystallization device according to any one of claims 1 to 9, characterized in that: include: After the raw material enters the crystallization mechanism (1) through the feeding mechanism (2), crystals are precipitated in the crystallization mechanism (1) and dried; Impurities on the inner bottom surface of the filter bag (24) are blown away by the cleaning component (33), and the cleaning component (33) prevents its own air outlet from being blocked.

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