Liftable automatic sampling device

By designing a liftable automatic sampling device, using motor transmission and multi-link structure, automated sampling of bioreactors is realized, solving the problem of time-consuming and labor-intensive manual sampling in the prior art, and improving detection efficiency and accuracy.

CN120192835APending Publication Date: 2025-06-24WUXI TMAXTREE BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202311791126.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-12-24
Publication Date
2025-06-24

AI Technical Summary

Technical Problem

In biological experiments, solutions in bioreactors require frequent sampling and testing, but the existing technology relies on manual operations and is time-consuming and labor-intensive, and cannot achieve real-time online testing.

Method used

An automatic sampling device that can be lifted and lowered is designed. Through the motor, the screw drives the gears and racks to move, realize the up and down movement of the lift plate and the sampling head, and combines the multi-link structure to realize the automatic sampling function.

Benefits of technology

Automatic bioreactor sampling is realized, reducing the time and energy of manual operation, real-time online detection can be achieved during the biological reaction process, and improving detection efficiency and accuracy.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention discloses a liftable automatic sampling device which comprises a base, a motor fixed on the base, a screw rod, a first lifting plate, a second lifting plate, a third lifting plate, a fourth lifting plate and a sampling head, a synchronous wheel and a synchronous belt are arranged at the bottom of the screw rod, the synchronous belt is connected with the synchronous wheel and the motor, and a nut is arranged on the screw rod. And the nut is fixedly connected with the second lifting plate. The motor drives the lead screw to drive the gear and the rack to move so as to drive the sampling head on the lifting plate to move up and down, the three connecting rods are designed at the sampling head, the position of the sampling needle can be adjusted in the horizontal direction, and the function of automatically sampling from the bioreactor is achieved through multi-dimensional adjustment.
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Description

Technical Field

[0001] The present invention relates to the field of sampling devices, and particularly to a liftable automatic sampling device. Background Art

[0002] In biological experiments, it is often necessary to detect the solution in a bioreactor. Since bioreactors are usually used to monitor biological reaction conditions, on-line detection of biochemical parameters cannot be obtained in real time. However, during the biological reaction process, the growth and metabolism of organisms are vigorous, and the biochemical indexes of organisms will change greatly in a short period of time. Therefore, it is necessary to sample and detect frequently. The conventional method is to rely on experimenters to take samples manually at regular intervals. This method requires long-term manual on-duty, which is time-consuming and laborious. Summary of the Invention

[0003] In order to overcome the above problems, the present invention provides a liftable automatic sampling device, which includes a base, a motor fixed on the base, a lead screw, a first lifting plate, a second lifting plate, a third lifting plate, a fourth lifting plate and a sampling head. A synchronous wheel and a synchronous belt are arranged at the bottom of the lead screw. The synchronous belt connects the synchronous wheel and the motor. A nut is arranged on the lead screw, and the nut is fixedly connected with the second lifting plate; the first lifting plate is fixedly connected with the lead screw, the first lifting plate is fixed on the base, the first lifting plate and the second lifting plate are arranged parallel and opposite to each other. A first slide rail and a first rack are arranged on one side of the first lifting plate opposite to the second lifting plate. The third lifting plate is arranged parallel and opposite to the second lifting plate. A second rack is arranged on one side of the third lifting plate opposite to the second lifting plate. A first gear is connected to the second lifting plate, and the first gear meshes with the first rack and the second rack respectively. A first slider is arranged on one side of the second lifting plate opposite to the first lifting plate, and the first slider is slidably connected with the first slide rail; a third rack and a second slide rail are arranged on one side of the second lifting plate opposite to the third lifting plate. A fourth rack and a third slider are arranged on one side of the fourth lifting plate opposite to the third lifting plate. A second gear is arranged on the third lifting plate, and the second gear meshes with the third rack and the fourth rack respectively. A second slider is arranged on one side of the third lifting plate opposite to the second lifting plate, and the second slide rail is slidably connected with the second slider; a third slide rail is arranged on one side of the third lifting plate opposite to the fourth lifting plate, and the third slide rail is slidably connected with the third slider; the top of the fourth lifting plate is connected with the sampling head.

[0004] In some embodiments, the sampling head includes a first connecting rod, a second connecting rod and a third connecting rod. The first connecting rod is rotatably connected with the fourth lifting plate, the first connecting rod is rotatably connected with the second connecting rod, and the second connecting rod is rotatably connected with the third connecting rod.

[0005] In some embodiments, a sampling needle is connected to the third connecting rod.

[0006] In some embodiments, the sampling needle is a hollow metal tube.

[0007] In some embodiments, the motor is a stepper motor.

[0008] In the present invention, the motor drives a lead screw to drive the movement of a gear and a rack, and further drives the sampling head on the lifting plate to move up and down. A three-link mechanism is designed at the sampling head, which can adjust the position of the sampling needle in the horizontal direction. Through multi-dimensional adjustment, the function of automatically sampling from a bioreactor is realized. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] The above and / or additional aspects and advantages of the present invention will become apparent and be readily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0010] Figure 1 is a schematic structural diagram of an embodiment of the present invention;

[0011] Figure 2 is a schematic diagram of a partial structure of an embodiment of the present invention;

[0012] Figure 3 is a side view of an embodiment of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0013] The embodiments of the present invention will be described in detail below. Examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0014] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for facilitating the description of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless otherwise specifically defined.

[0015] In the description of the present invention, it should be noted that, unless otherwise clearly specified and defined, the terms "installed", "connected", and "coupled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or a connection that allows mutual communication; it can be directly connected, or indirectly connected through an intermediate medium, and can be the internal communication of two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0016] In the description of the present invention, unless otherwise clearly specified and defined, the first feature being "on" or "under" the second feature may include the first and second features being in direct contact, or may include the first and second features not being in direct contact but being in contact through additional features therebetween. Moreover, the first feature being "above", "over", and "on top of" the second feature includes the first feature being directly above and obliquely above the second feature, or merely indicating that the first feature has a higher horizontal height than the second feature. The first feature being "under", "below", and "beneath" the second feature includes the first feature being directly below and obliquely below the second feature, or merely indicating that the first feature has a lower horizontal height than the second feature.

[0017] The following disclosure provides many different embodiments or examples for implementing different structures of the present invention. To simplify the disclosure of the present invention, the components and settings of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. In addition, the present invention may repeat reference numerals and / or reference letters in different examples. This repetition is for the purpose of simplification and clarity, and does not itself indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides examples of various specific processes and materials, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0018] Referring to Figures 1-3 , the present invention provides a liftable automatic sampling device, including a base 1, a motor 2 fixed on the base 1, a lead screw 3, a first lifting plate 4, a second lifting plate 5, a third lifting plate 6, a fourth lifting plate 7, and a sampling head 21. A synchronous pulley and a synchronous belt are provided at the bottom of the lead screw 3. The synchronous belt connects the synchronous pulley and the motor 2. When the motor 2 rotates, through the coordinated transmission of the synchronous belt and the synchronous pulley, the lead screw 3 is driven to rotate.

[0019] A nut 8 is provided on the lead screw 3. The nut 8 is fixedly connected to the second lifting plate 5. When the lead screw 3 rotates, the nut 8 is also driven to rotate. The nut 8 moves upward or downward along the lead screw 3. Since the second lifting plate 5 is fixedly connected to the nut 8, the second lifting plate 5 moves synchronously with the nut 8.

[0020] The first lifting plate 4 is fixedly connected to the lead screw 3. The first lifting plate 4 is fixed on the base 1 and mainly serves as a support. The first lifting plate 4 and the second lifting plate 5 are arranged parallel and opposite to each other. On one side of the first lifting plate 4 relative to the second lifting plate 5, a first slide rail 15 and a first rack 11 are provided. The third lifting plate 6 is arranged parallel and opposite to the second lifting plate 5. On one side of the third lifting plate 6 relative to the second lifting plate 5, a second rack 12 is provided. A first gear 9 is connected to the second lifting plate 5. The first gear 9 meshes with the first rack 11 and the second rack 12 respectively. On one side of the second lifting plate 5 relative to the first lifting plate 4, a first slider 18 is provided. The first slider 18 is slidably connected to the first slide rail 15. The first lifting plate 4 and the second lifting plate 5 are tightly connected under the action of the first slide rail 15 and the first slider 18. The first slide rail 15 and the first slider 18 play a limiting role. Since the first rack 11 and the second rack 12 are respectively meshed with the first gear 9, when the first gear 9 rotates, it will drive the third lifting plate 6 to move.

[0021] On one side of the second lifting plate 5 relative to the third lifting plate 6, a third rack 13 and a second slide rail 16 are provided. On one side of the fourth lifting plate 7 relative to the third lifting plate 6, a fourth rack 14 and a third slider 20 are provided. A second gear 10 is provided on the third lifting plate 6. The second gear 10 meshes with the third rack 13 and the fourth rack 14 respectively. On one side of the third lifting plate 6 relative to the second lifting plate 5, a second slider 19 is provided. The second slide rail 16 and the second slider 19 are slidably connected; on one side of the third lifting plate 6 relative to the fourth lifting plate 7, a third slide rail 17 is provided. The third slide rail 17 and the third slider 20 are slidably connected.

[0022] Connected in this way, the movement of the second lifting plate 5 is transmitted to the third lifting plate 6 through the first gear 9 and the second rack 12. The third lifting plate 6 drives the fourth lifting plate 7 to move up and down through the second gear 10, the third rack 13 and the fourth rack 14. The third slide rail 17 and the third slider play a role in limiting and fixing.

[0023] The top of the fourth lifting plate 7 is connected to a sampling head 21. The sampling head 21 includes a first connecting rod 211, a second connecting rod 212 and a third connecting rod 213. The first connecting rod 211 is rotatably connected to the fourth lifting plate 7. The first connecting rod 211 is rotatably connected to the second connecting rod 212. The second connecting rod 212 is rotatably connected to the third connecting rod 213. The design of the multi-link enables the sampling head 21 to adjust the position more precisely.

[0024] A sampling needle 214 is connected to the third connecting rod 213. The sampling needle 214 is a hollow metal tube. The sampling needle 214 can be used to connect an external sampling tube. The sampling needle 214 extends into the container for sampling, and then the solution is output through the pipeline.

[0025] The motor 2 is preferably a stepper motor. By controlling the forward and reverse rotation of the stepper motor, the up and down movement of the second lifting plate 5, the third lifting plate 6, and the fourth lifting plate 7 is driven. The sampling head 21 can be adjusted to a suitable position for sampling according to the position of the container to be sampled.

[0026] In the description of this specification, the description with reference to terms such as "one embodiment", "certain embodiments", "schematic embodiments", "examples", "specific examples", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the said embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0027] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the claims and their equivalents.

Claims

1. An elevating automatic sampling device, characterized in that, It includes a base, a motor fixed on the base, a lead screw, a first lifting plate, a second lifting plate, a third lifting plate, a fourth lifting plate and a sampling head. A synchronous pulley and a synchronous belt are arranged at the bottom of the lead screw. The synchronous belt connects the synchronous pulley and the motor. A nut is arranged on the lead screw, and the nut is fixedly connected with the second lifting plate; the first lifting plate is fixedly connected with the lead screw, the first lifting plate is fixed on the base, the first lifting plate and the second lifting plate are arranged parallel and opposite to each other. A first slide rail and a first rack are arranged on one side of the first lifting plate opposite to the second lifting plate. The third lifting plate is arranged parallel and opposite to the second lifting plate. A second rack is arranged on one side of the third lifting plate opposite to the second lifting plate. A first gear is connected to the second lifting plate, and the first gear meshes with the first rack and the second rack respectively. A first slider is arranged on one side of the second lifting plate opposite to the first lifting plate, and the first slider is slidably connected with the first slide rail; a third rack and a second slide rail are arranged on one side of the second lifting plate opposite to the third lifting plate. A fourth rack and a third slider are arranged on one side of the fourth lifting plate opposite to the third lifting plate. A second gear is arranged on the third lifting plate, and the second gear meshes with the third rack and the fourth rack respectively. A second slider is arranged on one side of the third lifting plate opposite to the second lifting plate, and the second slide rail is slidably connected with the second slider; a third slide rail is arranged on one side of the third lifting plate opposite to the fourth lifting plate, and the third slide rail is slidably connected with the third slider; the sampling head is connected to the top of the fourth lifting plate.

2. The automatic sampling device capable of lifting according to claim 1, wherein The sampling head includes a first connecting rod, a second connecting rod and a third connecting rod. The first connecting rod is rotatably connected with the fourth lifting plate, the first connecting rod is rotatably connected with the second connecting rod, and the second connecting rod is rotatably connected with the third connecting rod.

3. The automatic sampling device capable of lifting according to claim 2, characterized in that, A sampling needle is connected to the third connecting rod.

4. The automatic sampling device capable of lifting according to claim 3, characterized in that, The sampling needle is a hollow metal tube.

5. The automatic sampling device capable of lifting according to claim 1, characterized in that, The motor is a stepper motor.