Sample analyzer and control method of sample analyzer

Abstract

The embodiment of the invention provides a sample analyzer, a control method of the sample analyzer and the sample analyzer. The sample analyzer comprises a pipetting device, a driving device, a reaction device and a detection device, the pipetting device comprises a power mechanism and a pipetting needle, and the driving device is used for driving the pipetting needle to move; the liquid suction / drainage operation of the sample analyzer comprises the following steps: the driving device drives the pipetting needle to horizontally move to a first preset position and descend to a liquid suction / drainage level at the first preset position, and the power mechanism controls the pipetting needle to suck / drain liquid at the liquid suction / drainage level; after liquid suction / drainage, the driving device drives the pipetting needle to ascend to a second preset position and horizontally move to leave the second preset position; wherein when the liquid suction / drainage amounts are different in at least two liquid suction / drainage operation processes, at least part of motion parameters of the driving device for driving the pipetting needle to move are different. Liquid spitting and liquid throwing of the pipetting needle can be prevented, the influence of liquid spitting and liquid throwing on the accuracy of liquid suction / drainage is reduced, and the accuracy is improved.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to a sample analyzer and a control method for the sample analyzer. Background Art

[0002] Sample analyzers usually transfer liquids such as samples and reagents through pipetting needles, and the test solution obtained by detecting the liquids such as samples and reagents can obtain test results; the accuracy of the liquid volume during liquid transfer will affect the accuracy of the test results. In the movement process of the pipetting needle of the related sample analyzer, sometimes problems such as liquid spitting and liquid splashing at the needle tip of the pipetting needle occur, resulting in a decrease in the accuracy of the transferred liquid volume, and sometimes it will also cause machine failures. Summary of the Invention

[0003] This application provides a sample analyzer and a control method for the sample analyzer, which can improve the accuracy of liquid suction / discharge.

[0004] In a first aspect, an embodiment of this application provides a sample analyzer, including:

[0005] A pipetting device, the pipetting device includes a power mechanism and a pipetting needle, and the power mechanism is used to provide power for the pipetting needle to suck and / or discharge liquid;

[0006] A driving device, the driving device is used to drive the pipetting needle to move;

[0007] A reaction device, the reaction device is used to process the liquid provided by the pipetting device to obtain a test solution;

[0008] A detection device, the detection device is used to detect the test solution;

[0009] The liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to move horizontally to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to suck / discharge liquid at the liquid suction / discharge level, and after liquid suction / discharge, the driving device drives the pipetting needle to rise to a second preset position and move horizontally away from the second preset position; wherein, when there are at least two times that the liquid volumes of liquid suction / discharge are different during the liquid suction / discharge operation process, at least some of the movement parameters of the driving device driving the pipetting needle to move are different.

[0010] In a second aspect, an embodiment of this application provides a sample analyzer, including:

[0011] A pipetting device, the pipetting device includes a power mechanism and a pipetting needle, and the power mechanism is used to provide power for the pipetting needle to suck and / or discharge liquid;

[0012] A sensing device, which is connected to the pipetting needle and is used to obtain the pressure information and / or flow information of the liquid in the pipetting needle;

[0013] A driving device, which is used to drive the pipetting needle to move;

[0014] A reaction device, which is used to process the liquid provided by the pipetting device to obtain a test solution;

[0015] A detection device, which is used to detect the test solution;

[0016] The liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to move horizontally to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after liquid suction / discharge, the driving device drives the pipetting needle to rise to a second preset position and move horizontally away from the second preset position;

[0017] A control device, which is used to obtain the pressure information and / or flow information of the liquid in the pipetting needle through the sensing device during the liquid suction / discharge operation, and determine at least some of the movement parameters of the driving device driving the pipetting needle according to the pressure information and / or flow information of the liquid in the pipetting needle.

[0018] In a third aspect, an embodiment of the present application provides a control method for a sample analyzer, including:

[0019] During the liquid suction / discharge operation of the sample analyzer, the driving device drives the pipetting needle to move horizontally to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after liquid suction / discharge, the driving device drives the pipetting needle to rise to a second preset position and leave the second preset position;

[0020] Wherein, when the liquid volumes of liquid suction / discharge are different during at least two liquid suction / discharge operations, at least some of the movement parameters of the driving device driving the pipetting needle are different.

[0021] In a second aspect, an embodiment of the present application provides a control method for a sample analyzer, including:

[0022] During the process of the sample analyzer performing liquid suction / discharge operations, the driving device drives the pipetting needle to move horizontally to a first preset position and then move downward to the liquid suction / discharge level at the first preset position. The power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to move upward to a second preset position and leave the second preset position;

[0023] Wherein, during the process of the liquid suction / discharge operation, pressure information and / or flow information of the liquid inside the pipetting needle are acquired, and at least some of the movement parameters of the driving device driving the pipetting needle to move are determined according to the pressure information and / or flow information of the liquid inside the pipetting needle.

[0024] The sample analyzer and the control method of the sample analyzer provided by the embodiments of the present application. The sample analyzer includes: a pipetting device, a driving device, a reaction device, and a detection device; the pipetting device includes a power mechanism and a pipetting needle, and the power mechanism is used to provide power for sucking and / or discharging liquid by the pipetting needle; the driving device is used to drive the pipetting needle to move; the reaction device is used to process the liquid provided by the pipetting device to obtain a test solution to be tested; the detection device is used to detect the test solution to be tested; the liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to move horizontally to a first preset position and then move downward to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to move upward to a second preset position and move horizontally away from the second preset position; wherein, when there are at least two liquid suction / discharge operations with different liquid volumes during the liquid suction / discharge operation, at least some of the movement parameters of the driving device driving the pipetting needle to move are different. By having at least some of the movement parameters of the pipetting needle different when the liquid volumes of the liquid suction / discharge are different, it is possible to prevent the pipetting needle from spitting and splashing liquid at the needle tip, reduce or eliminate the influence of problems such as the pipetting needle spitting and splashing liquid at the needle tip on the accuracy of the liquid suction / discharge, and improve the accuracy of the sample analysis result.

[0025] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure content of the embodiments of the present application. Description of the Drawings

[0026] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0027] Figure 1 It is a schematic structural diagram of a sample analyzer provided by the embodiments of the present application;

[0028] Figure 2 is a schematic block diagram of a sample analyzer in an embodiment of the present application;

[0029] Figure 3 is a schematic block diagram of a sample analyzer in another embodiment of the present application;

[0030] Figure 4 is a schematic structural diagram of a sample analyzer in yet another embodiment of the present application;

[0031] Figure 5 is a schematic flowchart of a control method for a sample analyzer provided in an embodiment of the present application;

[0032] Figure 6 is a schematic flowchart of a control method for a sample analyzer provided in another embodiment of the present application.

[0033] Explanation of reference numerals:

[0034] 110, pipetting device; 111, power mechanism; 112, pipetting needle; 120, driving device; 130, reaction device; 140, detection device; 150, control device; 160, sensing device;

[0035] 10, functional module; 11, sample component; 12, sample dispensing mechanism; 13, reagent component; 14, reagent dispensing mechanism; 15, mixing mechanism; 16, reaction component; 17, optical measurement component; 20, input module; 30, display module; 40, memory; 50, processor; 60, alarm module. Detailed implementation manners

[0036] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0037] The flowcharts shown in the accompanying drawings are only illustrative examples, and do not necessarily include all the contents and operations / steps, nor do they necessarily need to be executed in the described order. For example, some operations / steps can be decomposed, combined, or partially merged, so the actual execution order may be changed according to the actual situation.

[0038] Next, some embodiments of the present application will be described in detail in conjunction with the accompanying drawings. Without conflict, the following embodiments and the features in the embodiments can be combined with each other.

[0039] Please refer to Figure 1 , Figure 1It is a schematic structural diagram of a sample analyzer provided by an embodiment of the present application.

[0040] In some embodiments, the sample analyzer includes, but is not limited to, at least one of the following: biochemical analyzer, electrolyte analyzer, immunoassay analyzer, coagulation analyzer, urine analyzer.

[0041] Exemplarily, the sample analyzer can be a biochemical analyzer, and at least one of an electrolyte analysis module, an immunoassay analysis module, a coagulation analysis module, a urine analysis module, etc. can be carried in the biochemical analyzer.

[0042] Before specifically describing the present invention, first, the structure of the sample analyzer in some embodiments will be described.

[0043] Please refer to Figure 2 , an embodiment discloses a sample analyzer, including at least one functional module 10 (or one or more functional modules 10), an input module 20, a display module 30, a memory 40, a processor 50, and an alarm module 60, which will be described separately below.

[0044] Each functional module 10 is used to complete at least one function required in the sample analysis process. These functional modules 10 cooperate with each other to complete the sample analysis and obtain the result of the sample analysis. Please refer to Figure 3 , which is a sample analyzer of an embodiment, and some examples of the functional module 10 are given therein. For example, the functional module 10 may include a sample component 11, a sample dispensing mechanism 12, a reagent component 13, a reagent dispensing mechanism 14, a mixing mechanism 15, a reaction component 16, a photometric component 17, etc.

[0045] The sample component 11 is used to carry the sample. In some examples, the sample component 11 may include a sample distribution module (SDM, Sample Delivery Module) and a front-end track; in other examples, the sample component 11 may also be a sample disk, and the sample disk includes a plurality of sample positions for placing samples such as sample tubes. By rotating its disk structure, the sample disk can schedule the sample to a corresponding position, such as the position for the sample dispensing mechanism 12 to aspirate the sample.

[0046] The sample dispensing mechanism 12 is used to aspirate the sample and discharge it into the reaction cup to be loaded with the sample. For example, the sample dispensing mechanism 12 may include a sample needle, and the sample needle moves in two or three dimensions in space through a two-dimensional or three-dimensional drive mechanism, so that the sample needle can move to aspirate the sample carried by the sample component 11, and move to the reaction cup to be loaded with the sample and discharge the sample into the reaction cup.

[0047] The reagent component 13 is used to carry reagents. In one embodiment, the reagent component 13 can be a reagent tray, which is arranged in a disc shape and has a plurality of positions for carrying reagent containers. The reagent component 13 can rotate and drive the reagent containers it carries to rotate, so as to rotate the reagent containers to specific positions, such as the positions where the reagent dispensing mechanism 14 sucks reagents. The number of the reagent components 13 can be one or more.

[0048] The reagent dispensing mechanism 14 is used to suck reagents and discharge them into the reaction cups to which reagents are to be added. In one embodiment, the reagent dispensing mechanism 14 can include a reagent needle, and the reagent needle can perform two-dimensional or three-dimensional movements in space through a two-dimensional or three-dimensional drive mechanism, so that the reagent needle can move to suck the reagents carried by the reagent component 13, and move to the reaction cups to which reagents are to be added, and discharge the reagents into the reaction cups.

[0049] The mixing mechanism 15 is used to mix the reaction liquid that needs to be mixed in the reaction cups. The number of the mixing mechanisms 15 can be one or more.

[0050] The reaction component 16 has at least one placement position, and the placement position is used to place the reaction cups and incubate the reaction liquid in the reaction cups. For example, the reaction component 16 can be a reaction tray, which is arranged in a disc shape and has one or more placement positions for placing reaction cups. The reaction tray can rotate and drive the reaction cups in its placement positions to rotate, so as to schedule the reaction cups in the reaction tray and incubate the reaction liquid in the reaction cups.

[0051] The optical measurement component 17 is used to perform optical measurement on the reaction liquid after incubation to obtain the reaction data of the sample. For example, the optical measurement component 17 detects the luminescence intensity of the reaction liquid to be measured, and calculates the concentration of the component to be measured in the sample through a calibration curve, etc. In one embodiment, the optical measurement component 17 is separately arranged outside the reaction component 16.

[0052] The above are some examples of the functional module 10. Next, other components and structures in the sample analyzer will be described.

[0053] The input module 20 is used to receive user input. Commonly, the input module 20 can be a mouse, a keyboard, etc. In some cases, it can also be a touch display screen. The touch display screen brings the functions of allowing users to input and display content. Therefore, in this example, the input module 20 and the display module 30 are integrated together. Of course, in some examples, the input module 20 can even be a voice input device that can recognize voices, etc.

[0054] The display module 30 can be used to display information. In some embodiments, the sample analyzer itself can integrate the display module. In some embodiments, the sample analyzer can also be connected to a computer device (such as a computer), and the information can be displayed through the display unit (such as a display screen) of the computer device. These all fall within the scope defined and protected by the display module 30 in this article.

[0055] The processor 50 is used to obtain the test data when the functional module 10 completes the sample analysis, and judge whether to trigger the alarm condition according to the test data and the alarm conditions in the memory 40. In some embodiments, the processor 50 obtains the reaction data of the sample and judges whether the reaction process of the sample is normal according to the alarm conditions.

[0056] The alarm module 60 is used to give an alarm when the processor 50 judges that the alarm condition is triggered. In some embodiments, when the alarm condition has a corresponding alarm identifier, when the processor 50 judges that the alarm condition is triggered, the alarm module 60 drives the display module 30 to display the alarm identifier corresponding to the alarm condition to give an alarm. In some examples, the alarm module 60 can be hardware with a display function, and even the alarm module 60 can be integrated with the display module 30 to give an alarm and prompt to the user through the displayed content.

[0057] For the convenience of description, the following mainly takes the biochemical analyzer as an example of the sample analyzer for description.

[0058] As Figure 1 shown, the sample analyzer according to the embodiment of the present application includes: a liquid transfer device 110, a driving device 120, a reaction device 130, and a detection device 140.

[0059] The liquid transfer device 110 includes a power mechanism 111 and a liquid transfer needle 112. The power mechanism 111 is used to provide power for the liquid transfer needle 112 to aspirate and / or discharge liquid. The liquid transfer needle 112 includes a sample needle and / or a reagent needle, or may include a liquid transfer needle 112 that can be reused as a sample needle and a reagent needle; the liquid aspirated and / or discharged by the liquid transfer needle 112 includes but is not limited to reagents, samples, and may also be a reaction solution, a cleaning solution, etc. prepared from reagents and samples, and of course it is not limited to this. The power mechanism 111 may include a syringe, and the syringes can all be connected to the liquid transfer needle 112 through pipelines.

[0060] The driving device 120 is used to drive the liquid transfer needle 112 to move. The driving device 120 includes, for example, a two-dimensional or three-dimensional driving mechanism, which can drive the liquid transfer needle 112 to perform two-dimensional or three-dimensional movement in space. Exemplarily, the driving device 120 can drive the liquid transfer needle 112 to move in the vertical direction, that is, to move up or down, and can also drive the liquid transfer needle 112 to move in the horizontal direction.

[0061] The reaction device 130 is used to process the liquid provided by the pipetting device 110 to obtain a test solution to be tested. The reaction device 130 includes, for example, the aforementioned reaction component 16, and may also include the aforementioned mixing mechanism 15.

[0062] The detection device 140 is used to detect the test solution to be tested. The detection device 140 includes, for example, the aforementioned optical measurement component 17, but is not limited thereto.

[0063] Please refer to Figure 1 , the liquid suction / discharge operation of the sample analyzer includes: the driving device 120 drives the pipetting needle 112 to move horizontally to the first preset position A and move downward to the liquid suction / discharge level B at the first preset position A, the power mechanism 111 controls the pipetting needle 112 to perform liquid suction / discharge at the liquid suction / discharge level B, and after the liquid suction / discharge, the driving device 120 drives the pipetting needle 112 to move upward to the second preset position C and move horizontally away from the second preset position C.

[0064] The first preset position A and the second preset position C are positions above the liquid suction / discharge level B. The first preset position A and the second preset position C can be the same position or different positions.

[0065] In some embodiments, the liquid suction operation of the sample analyzer includes: the driving device 120 drives the pipetting needle 112 to move horizontally to the first preset position A1 above the liquid suction level B1 and move downward to the liquid suction level B1 at the first preset position A1, the power mechanism 111 controls the pipetting needle 112 to perform liquid suction at the liquid suction level B1, and after the liquid suction, the driving device 120 drives the pipetting needle 112 to move upward to the second preset position C1 and move horizontally away from the second preset position C1; after this liquid suction operation, the liquid discharge operation of the sample analyzer may include: the driving device 120 drives the pipetting needle 112 to move horizontally to the first preset position A2 above the liquid discharge level B2 and move downward to the liquid discharge level B2 at the first preset position A2, the power mechanism 111 controls the pipetting needle 112 to perform liquid discharge at the liquid discharge level B2, and after the liquid discharge, the driving device 120 drives the pipetting needle 112 to move upward to the second preset position C2 and move horizontally away from the second preset position C2.

[0066] Wherein, when there are at least two times that the liquid volumes of the liquid suction / discharge during the liquid suction / discharge operation are different, at least some of the movement parameters of the driving device 120 driving the pipetting needle 112 to move are different.

[0067] In some embodiments, during at least two liquid aspiration operations, when the liquid volumes aspirated are different, at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 are different; or during at least two liquid discharge operations, when the liquid volumes discharged are different, at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 are different. In some other embodiments, when the liquid volume aspirated during the liquid aspiration operation is different from the liquid volume discharged during the liquid discharge operation, at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 can also be different.

[0068] By controlling at least some of the motion parameters of the pipetting needle 112 to be different when the liquid volumes aspirated / discharged are different in the embodiments of the present application, it is possible to prevent the pipetting needle 112 from spitting or splashing liquid at the needle tip, and can also reduce or eliminate the influence of problems such as the pipetting needle 112 spitting or splashing liquid on the accuracy of liquid aspiration / discharge, and improve the accuracy of the sample analysis results.

[0069] The motion parameters include speed and / or acceleration. Of course, it is not limited thereto. For example, it may also include the motion distance.

[0070] In some embodiments, taking the first liquid volume being less than the second liquid volume as an example, the speed of the driving device 120 driving the pipetting needle 112 when the liquid volume aspirated / discharged during the liquid aspiration / discharge operation is the first liquid volume is less than the speed of the driving device 120 driving the pipetting needle 112 when the liquid volume aspirated / discharged during the liquid aspiration / discharge operation is the second liquid volume.

[0071] For example, the first liquid volume is less than 10 microliters and the second liquid volume is greater than 10 microliters. Of course, it is not limited thereto.

[0072] When the liquid volume aspirated / discharged is small, reducing the speed of the pipetting needle 112 can prevent the pipetting needle 112 from spitting or splashing liquid at the needle tip, or can reduce the liquid volume loss caused by spitting or splashing, making the liquid volume aspirated / discharged more accurate. When the liquid volume aspirated / discharged is large, a larger speed of the pipetting needle 112 can improve the efficiency of liquid aspiration / discharge. Even if the pipetting needle 112 spits or splashes liquid at the needle tip, due to the large liquid volume aspirated / discharged, the influence caused by the liquid volume loss due to splashing is small, and the high accuracy of the sample analysis results can still be ensured.

[0073] In some embodiments, taking the first liquid volume being less than the second liquid volume as an example, the acceleration of the driving device 120 driving the pipetting needle 112 when the liquid volume aspirated / discharged during the liquid aspiration / discharge operation is the first liquid volume is less than the acceleration of the driving device 120 driving the pipetting needle 112 when the liquid volume aspirated / discharged during the liquid aspiration / discharge operation is the second liquid volume.

[0074] When the liquid volume for liquid suction / discharge is small, reducing the acceleration during the movement of the pipetting needle 112 can prevent liquid from spitting out or splashing from the tip of the pipetting needle 112, or can reduce the liquid volume loss caused by liquid spitting or splashing, making the liquid volume for liquid suction / discharge more accurate. When the liquid volume for liquid suction / discharge is large, the acceleration of the movement of the pipetting needle 112 is large, the operation is more sensitive, the movement speed within the same movement distance can be faster, and the efficiency of liquid suction / discharge can be improved. Even if liquid spits out or splashes from the tip of the pipetting needle 112, due to the large liquid volume for liquid suction / discharge, the impact caused by the liquid volume loss due to liquid splashing is small, and the high accuracy of the sample analysis result can still be ensured.

[0075] The movement of the pipetting needle 112 includes movements in the vertical direction, such as upward movement or downward movement, and can also include movements in the horizontal direction, such as horizontal movement to the first preset position or leaving the second preset position. When there are at least two liquid suction / discharge operations with different liquid volumes, at least some of the movement parameters of the driving device 120 driving the pipetting needle 112 to move in the vertical direction are different, and / or at least some of the movement parameters of the driving device 120 driving the pipetting needle 112 to move in the horizontal direction are different.

[0076] In some embodiments, during at least two liquid suction operations, the movement parameters of the driving device 120 driving the pipetting needle 112 to move upward to the second preset position are different, and / or the movement parameters of the horizontal movement leaving the second preset position are different.

[0077] Taking the first liquid volume being less than the second liquid volume as an example, the movement parameters of the pipetting needle 112 moving upward after sucking the first liquid volume are less than the movement parameters of the pipetting needle 112 moving upward after sucking the second liquid volume; after sucking the liquid of the first liquid volume, reducing the movement parameters of the pipetting needle 112 moving upward can prevent the liquid sucked by the pipetting needle 112 from spitting out from the tip of the pipetting needle 112 during the upward movement of the pipetting needle 112; after sucking the liquid of the second liquid volume, the movement parameters of the pipetting needle 112 moving upward can be larger to improve the efficiency.

[0078] Taking the first liquid volume being less than the second liquid volume as an example, the movement parameters of the pipetting needle 112 moving horizontally away from the second preset position after sucking the first liquid volume are less than the movement parameters of the pipetting needle 112 moving horizontally away from the second preset position after sucking the second liquid volume. After sucking the liquid of the first liquid volume, reducing the movement parameters of the pipetting needle 112 moving horizontally can prevent the liquid sucked by the pipetting needle 112 from spitting out from the tip of the pipetting needle 112 during the horizontal movement of the pipetting needle 112; after sucking the liquid of the second liquid volume, the movement parameters of the pipetting needle 112 moving horizontally can be larger to improve the efficiency.

[0079] In some embodiments, during at least two liquid discharging operations, the motion parameters of the driving device 120 driving the pipetting needle 112 to move horizontally to the first preset position are different, and / or the motion parameters of the driving device 120 driving the pipetting needle 112 to move downward to the liquid discharging position at the first preset position are different.

[0080] Taking the case where the first liquid volume is less than the second liquid volume as an example, the motion parameters of the pipetting needle 112 containing at least the first liquid volume moving horizontally are less than those of the pipetting needle 112 containing at least the second liquid volume moving horizontally; by reducing the motion parameters of the pipetting needle 112 containing at least the first liquid volume moving horizontally, it is possible to prevent the liquid in the pipetting needle 112 from spitting out from the needle orifice of the pipetting needle 112 during the horizontal movement of the pipetting needle 112, and the accuracy of the liquid volume discharged at the liquid discharging position can be ensured; the motion parameters of the pipetting needle 112 containing at least the second liquid volume moving horizontally can be larger to improve efficiency.

[0081] Taking the case where the first liquid volume is less than the second liquid volume as an example, the motion parameters of the pipetting needle 112 containing at least the first liquid volume moving downward are less than those of the pipetting needle 112 containing at least the second liquid volume moving downward; by reducing the motion parameters of the pipetting needle 112 containing at least the first liquid volume moving downward, it is possible to prevent the liquid in the pipetting needle 112 from spitting out from the needle orifice of the pipetting needle 112 or prevent air from entering the pipetting needle 112 during the downward movement of the pipetting needle 112, and the accuracy of the liquid volume discharged at the liquid discharging position can be ensured; the motion parameters of the pipetting needle 112 containing at least the second liquid volume moving downward can be larger to improve efficiency.

[0082] Optionally, during the process of the driving device 120 driving the pipetting needle 112 to move horizontally to the first preset position above the liquid suction position and / or during the process of moving downward to the liquid suction position at the first preset position, the power mechanism 111 controls the pipetting needle 112 to suck in isolation air. Before the pipetting needle 112 sucks the liquid at the liquid suction position, the isolation air is sucked in first to separate the liquid at the liquid suction position from the liquid in the power mechanism 111, and prevent the liquid at the liquid suction position from coming into contact and mixing with the liquid in the power mechanism 111.

[0083] In some embodiments, during at least two liquid suction operations, the motion parameters of the driving device 120 driving the pipetting needle 112 to move horizontally to the first preset position above the liquid suction position are different, and / or the motion parameters of the driving device 120 driving the pipetting needle 112 to move downward to the liquid suction position at the first preset position are different. Exemplarily, at least after the pipetting needle 112 sucks in isolation air, the motion parameters of the driving device 120 driving the pipetting needle 112 to move horizontally and / or downward are different.

[0084] Taking the example where the first liquid volume is less than the second liquid volume, when the liquid volume to be aspirated at the aspiration level is the first liquid volume, the movement parameters of the pipetting needle 112 are relatively small after the pipetting needle 112 aspirates the isolation air. For example, it can prevent the isolation air aspirated by the pipetting needle 112 from escaping from the needle orifice of the pipetting needle 112, and prevent the liquid volume aspirated at the subsequent aspiration level from being greater than the first liquid volume due to the reduction of the isolation air, that is, it can improve the accuracy of liquid aspiration. When the liquid volume to be aspirated at the aspiration level is the second liquid volume, the movement parameters of the pipetting needle 112 can be relatively large after the pipetting needle 112 aspirates the isolation air to improve the efficiency; moreover, even if the isolation air aspirated by the pipetting needle 112 escapes from the needle orifice of the pipetting needle 112, since the liquid volume of liquid aspiration / discharge is large, the influence of the additional liquid volume aspirated at the subsequent aspiration level on the second liquid volume is small.

[0085] Optionally, as Figure 4 shown, the sample analyzer further includes a control device 150. The control device 150 may include Figure 2 the processor 50 in, of course, it is not limited thereto. For example, the control device 150 may include other processors other than the processor 50, such as the control device 150 includes a processor dedicated to controlling the driving device 120.

[0086] In some embodiments, the control device 150 is configured to determine at least some of the movement parameters of the driving device 120 driving the pipetting needle 112 during the liquid aspiration / discharge operation according to the detection item parameters of the sample corresponding to the liquid aspiration / discharge operation.

[0087] Exemplarily, the liquid volume of liquid aspiration / discharge during the liquid aspiration / discharge operation can be determined according to the detection item parameters, and at least some of the movement parameters of the pipetting needle 112 movement can be determined according to the liquid volume of liquid aspiration / discharge. The liquid volumes of liquid aspiration / discharge corresponding to the detection item parameters of at least two samples are different, or the liquid volumes of liquid aspiration / discharge corresponding to multiple liquid aspiration / discharge operations of the detection item parameters of one sample are different.

[0088] Exemplarily, according to the detection item parameters of the current sample, the liquid volume aspirated during each aspiration operation and the liquid volume discharged during each discharge operation are determined, and the movement parameters of the corresponding pipetting needle 112 movement are determined.

[0089] Exemplarily, the detection item parameters of the sample include but are not limited to at least one of the following: the type of the detection item, the type of the sample, the type of the corresponding reagent, the sample volume, the dilution ratio, of course, it is not limited thereto.

[0090] In some embodiments, the control device 150 is configured to determine at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 during the liquid suction / discharge operation according to the liquid parameters of the liquid corresponding to the suction / discharge operation, such as the sample or reagent; the liquid parameters include at least one of the following: the volume of the liquid, the type of the liquid, and the physical property parameters of the liquid.

[0091] Exemplarily, the corresponding motion parameters are determined according to the volume of the liquid corresponding to the suction / discharge operation. When the volume is small, smaller motion parameters are adopted to prevent problems such as liquid spitting and liquid splashing, so as to improve the accuracy of the liquid volume in the suction / discharge operation; when the volume is large, larger motion parameters are adopted to improve the efficiency of the suction / discharge operation.

[0092] Exemplarily, the physical property parameters of the liquid include but are not limited to at least one of the following: viscosity, surface tension. Optionally, the physical property parameters of the liquid can be determined according to the type of the liquid, and of course, it is not limited thereto. For example, the corresponding physical property parameters can be detected for the liquid.

[0093] Exemplarily, according to the type and / or physical property parameters of the liquid corresponding to the suction / discharge operation, it can be determined whether the liquid in the pipetting needle 112 is prone to liquid spitting and liquid splashing during the suction / discharge operation. For example, when the volume of the suction / discharge liquid is the same, the smaller the viscosity and / or surface tension of the liquid corresponding to the suction / discharge operation, the smaller the determined motion parameters of the movement of the pipetting needle 112, which can prevent the pipetting needle 112 from spitting and splashing liquid.

[0094] By determining at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 during the suction / discharge operation according to the type and / or physical property parameters of the liquid, for example, determining the motion parameters corresponding to different volumes of the suction / discharge liquid, the accuracy and efficiency of the suction / discharge operation can be improved.

[0095] Optionally, as Figure 4 shown, the sample analyzer further includes a control device 150, and may further include a sensing device 160.

[0096] The sensing device 160 is connected to the pipetting needle 112 and is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle 112.

[0097] Exemplarily, the sensing device 160 is provided on the pipetting needle 112, or provided on the power mechanism 111, such as a syringe, or can be provided on the pipeline between the pipetting needle 112 and the power mechanism 111; for example, it can also be provided at the connection between the pipetting needle 112 and the pipeline, or at the connection between the power mechanism 111 and the pipeline.

[0098] Exemplarily, the pressure information of the liquid in the pipetting needle 112 includes at least one of the following: pressure magnitude, pressure change rate. For example, the sensing device 160 includes a pressure sensor.

[0099] Exemplarily, the flow information of the liquid in the pipetting needle 112 includes at least one of the following: flow velocity magnitude, flow rate magnitude, flow velocity change rate. For example, the sensing device 160 includes a flow rate sensor and / or a flow velocity sensor.

[0100] The control device 150 is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle 112 through the sensing device 160 during the liquid suction / discharge operation, and determine at least some of the motion parameters for the driving device 120 to drive the pipetting needle 112 to move according to the pressure information and / or flow information of the liquid in the pipetting needle 112.

[0101] In some embodiments, at least some of the motion parameters for the driving device 120 to drive the pipetting needle 112 to move during the liquid suction / discharge operation are determined according to the pressure information and / or flow information of the liquid in the pipetting needle 112, and the liquid volume of the liquid suction / discharge during the liquid suction / discharge operation.

[0102] In the embodiments of the present application, at least some of the motion parameters for the driving device 120 to drive the pipetting needle 112 to move can be controlled according to the pressure information and / or flow information of the liquid in the pipetting needle 112, that is, the current working conditions of the pipetting needle 112, so that the movement of the pipetting needle 112 can adapt to different working conditions, and the states of the liquid, isolated air and other fluids in the pipetting needle 112 are more stable, thereby improving the accuracy and efficiency of the liquid volume of the liquid suction / discharge. For example, compared with the related art in which the pipetting needle 112 is driven to move by a single motion parameter, the embodiments of the present application can reduce or eliminate the influence caused by the reduction of the accuracy of the transferred liquid volume due to problems such as liquid spitting and liquid splashing at the needle tip of the pipetting needle 112.

[0103] Exemplarily, when determining at least some of the motion parameters for the driving device 120 to drive the pipetting needle 112 to move according to the pressure information and / or flow information of the liquid in the pipetting needle 112: the speed and / or acceleration of the pipetting needle 112 to move is negatively correlated with at least one of the following information: flow velocity magnitude, pressure change rate, flow velocity change rate.

[0104] For example, when the liquid volume of the liquid suction / discharge is the same, if the flow velocity of the liquid in the pipetting needle 112 is relatively large, it can be determined that the liquid in the pipetting needle 112 is likely to spit out liquid. By reducing the speed and acceleration of the pipetting needle 112 to move, the occurrence of liquid spitting can be prevented, thereby improving the accuracy of the liquid volume of the liquid suction / discharge.

[0105] For example, when the liquid volume of suction / discharge is the same, if the pressure change and / or flow rate change of the liquid in the pipetting needle 112 is relatively fast, it can be determined that the liquid in the pipetting needle 112 is prone to liquid spitting. By reducing the speed and acceleration of the movement of the pipetting needle 112, liquid spitting can be prevented, so as to improve the accuracy of the liquid volume of suction / discharge.

[0106] Exemplarily, when determining at least some of the movement parameters of the driving device 120 for driving the movement of the pipetting needle 112 according to the pressure information and / or flow information of the liquid in the pipetting needle 112: the speed and / or acceleration of the movement of the pipetting needle 112 is positively correlated with at least one of the following information: the magnitude of the pressure, the magnitude of the flow rate.

[0107] For example, when the liquid volume of suction / discharge is the same, if the pressure of the liquid in the pipetting needle 112 is relatively small, it can be determined that the liquidity of the liquid in the pipetting needle 112 is relatively good and it is relatively easy to have liquid spitting. By reducing the speed and acceleration of the movement of the pipetting needle 112, liquid spitting can be prevented, so as to improve the accuracy of the liquid volume of suction / discharge.

[0108] For example, if the flow rate of the liquid in the pipetting needle 112 is relatively large, it can be determined that the liquid volume of suction / discharge of the pipetting needle 112 is relatively large. By increasing the speed and acceleration of the movement of the pipetting needle 112, the efficiency of the suction / discharge operation can be improved.

[0109] In some embodiments, the control device 150 is configured to determine at least some of the movement parameters of the driving device 120 for driving the movement of the pipetting needle 112 according to at least one of the following pressure information and / or flow information: the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 sucks liquid at the liquid suction position; the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 moves upward from the liquid suction position to a second preset position above the liquid suction position; the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 moves horizontally away from the second preset position above the liquid suction position; the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 moves downward from a first preset position above the liquid discharge position to the liquid discharge position.

[0110] Exemplarily, the pressure information and / or flow information of the liquid in the pipetting needle 112 can be obtained at at least one time from the start of liquid aspiration to before the end of liquid discharge. According to the obtained pressure information and / or flow information, the speed and / or acceleration of the movement of the pipetting needle 112 at a subsequent time can be determined. For example, the pressure information and / or flow information of the liquid currently in the pipetting needle 112 can be collected in real time, and according to the collected pressure information and / or flow information, the speed and / or acceleration of the movement of the pipetting needle 112 can be adaptively adjusted to achieve dynamic adjustment of the movement of the pipetting needle 112 and improve the state stability of fluids such as the liquid and isolated air in the pipetting needle 112; when the pressure information and / or flow information is abnormal, the speed and / or acceleration of the movement of the pipetting needle 112 can also be adjusted so that the pressure information and / or flow information of the liquid in the pipetting needle 112 can quickly return to normal, preventing the problem from further deteriorating and effectively eliminating the abnormality at the budding stage, thereby enhancing the overall stability and reliability of the sample analyzer.

[0111] Exemplarily, the control device 150 is configured to determine at least one of the following movement parameters according to the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 aspirates liquid at the liquid aspiration position: at least part of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move upward from the liquid aspiration position to a second preset position above the liquid aspiration position; at least part of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move horizontally away from the second preset position; at least part of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move horizontally to a first preset position above the liquid discharge position; at least part of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move downward from the first preset position to the liquid discharge position.

[0112] For example, when the pressure of the liquid in the pipetting needle 112 obtained during liquid aspiration is small and / or the flow rate is large and / or the pressure change and / or the flow rate change are fast and / or the flow rate is small, it can be determined that the subsequent speed and / or acceleration of the pipetting needle 112 are small to prevent liquid spitting and improve the accuracy of the liquid volume aspirated / discharged.

[0113] Exemplarily, the control device 150 can also be used to obtain the pressure information and / or flow information of the liquid in the pipetting needle 112 during the movement of the pipetting needle 112, and determine the speed and / or acceleration of the movement of the pipetting needle 112 at a subsequent time. For example, when the pipetting needle 112 moves upward from the liquid suction position to a second preset position above the liquid suction position, the pressure information and / or flow information of the liquid in the pipetting needle 112 is obtained to determine at least some of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move horizontally away from the second preset position; when the pipetting needle 112 moves horizontally away from the second preset position, the pressure information and / or flow information of the liquid in the pipetting needle 112 is obtained to determine at least some of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move downward from a first preset position above the liquid discharge position to the liquid discharge position.

[0114] Exemplarily, various pressure information and / or various flow information of the liquid in the pipetting needle 112 can also be used to comprehensively determine the movement parameters for driving the movement of the pipetting needle 112, so that the movement of the pipetting needle 112 can adapt to different working conditions, the states of fluids such as the liquid and the isolated air in the pipetting needle 112 are more stable, and the accuracy and efficiency of the liquid volume for liquid suction / discharge are improved.

[0115] The sample analyzer provided in the embodiment of the present application includes: a pipetting device, a driving device, a reaction device, and a detection device; the pipetting device includes a power mechanism and a pipetting needle, and the power mechanism is used to provide power for the pipetting needle to suck and / or discharge liquid; the driving device is used to drive the movement of the pipetting needle; the reaction device is used to process the liquid provided by the pipetting device to obtain a test solution to be tested; the detection device is used to detect the test solution to be tested; the liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to move horizontally to a first preset position and move downward to the liquid suction / discharge position at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge position, and after the liquid suction / discharge, the driving device drives the pipetting needle to move upward to a second preset position and move horizontally away from the second preset position; wherein, when there are at least two liquid suction / discharge operations with different liquid volumes for liquid suction / discharge, at least some of the movement parameters for the driving device to drive the movement of the pipetting needle are different. By having at least some of the movement parameters of the pipetting needle different when the liquid volumes for liquid suction / discharge are different, it is possible to prevent the pipetting needle from spitting or splashing liquid at the needle tip, reduce or eliminate the influence of problems such as spitting or splashing liquid at the needle tip of the pipetting needle on the accuracy of liquid suction / discharge, and improve the accuracy of the sample analysis result.

[0116] Please refer to the foregoing embodiments in conjunction with Figure 5 , Figure 5 which is a schematic flowchart of a control method for a sample analyzer provided in an embodiment of the present application.

[0117] As Figure 5 shown, the control method of the sample analyzer includes the following step S110.

[0118] Step S110: During the liquid suction / discharge operation of the sample analyzer, the driving device drives the pipetting needle to move horizontally to a first preset position and then move downward to the liquid suction / discharge level at the first preset position. The power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to move upward to a second preset position and leave the second preset position;

[0119] Wherein, when there are at least two liquid suction / discharge operations with different liquid volumes during the liquid suction / discharge process, at least some of the movement parameters of the driving device driving the pipetting needle are different.

[0120] In some embodiments, the speed of the driving device driving the pipetting needle during the liquid suction / discharge operation with a first liquid volume is less than the speed of the driving device driving the pipetting needle during the liquid suction / discharge operation with a second liquid volume; and / or the acceleration of the driving device driving the pipetting needle during the liquid suction / discharge operation with a first liquid volume is less than the acceleration of the driving device driving the pipetting needle during the liquid suction / discharge operation with a second liquid volume; wherein, the first liquid volume is less than the second liquid volume.

[0121] In some embodiments, during at least two liquid suction operations, the movement parameters of the driving device driving the pipetting needle to move upward to the second preset position are different, and / or the movement parameters of the driving device driving the pipetting needle to move horizontally away from the second preset position are different.

[0122] In some embodiments, during at least two liquid discharge operations, the movement parameters of the driving device driving the pipetting needle to move horizontally to the first preset position are different, and / or the movement parameters of the driving device driving the pipetting needle to move downward to the liquid discharge level at the first preset position are different.

[0123] In some embodiments, during the process of the driving device driving the pipetting needle to move horizontally above the liquid suction level to the first preset position and / or move downward to the liquid suction level at the first preset position, the power mechanism controls the pipetting needle to suck in isolation air;

[0124] During at least two liquid suction operations, the movement parameters of the driving device driving the pipetting needle to move horizontally above the liquid suction level to the first preset position are different, and / or the movement parameters of the driving device driving the pipetting needle to move downward to the liquid suction level at the first preset position are different.

[0125] In some embodiments, at least some of the motion parameters of the driving device driving the pipetting needle during the liquid suction / discharge operation can also be determined according to the detection item parameters of the sample corresponding to the liquid suction / discharge operation.

[0126] In some embodiments, at least some of the motion parameters of the driving device driving the pipetting needle during the liquid suction / discharge operation can also be determined according to the liquid parameters of the liquid corresponding to the liquid suction / discharge operation;

[0127] The liquid parameters include at least one of the following: the volume of the liquid, the type of the liquid, and the physical property parameters of the liquid.

[0128] In some embodiments, during the liquid suction / discharge operation, the pressure information and / or flow information of the liquid in the pipetting needle can also be obtained through the sensing device, and at least some of the motion parameters of the driving device driving the pipetting needle can be determined according to the pressure information and / or flow information of the liquid in the pipetting needle.

[0129] Exemplarily, the pressure information of the liquid in the pipetting needle includes at least one of the following: the magnitude of the pressure, the rate of change of the pressure; and / or the flow information of the liquid in the pipetting needle includes at least one of the following: the magnitude of the flow rate, the magnitude of the flow rate, the rate of change of the flow rate.

[0130] For example, the speed and / or acceleration of the pipetting needle movement is negatively correlated with at least one of the following information: the magnitude of the flow rate, the rate of change of the pressure, the rate of change of the flow rate; and / or

[0131] The speed and / or acceleration of the pipetting needle movement is positively correlated with at least one of the following states: the magnitude of the pressure, the magnitude of the flow rate.

[0132] The specific principles and implementation manners of the control method of the sample analyzer provided in the embodiments of the present application are similar to those of the sample analyzer in the foregoing embodiments, and will not be elaborated herein.

[0133] Please refer to the foregoing embodiments in conjunction with Figure 4 , Figure 4 which is a schematic block diagram of a sample analyzer provided in another embodiment of the present application.

[0134] As Figure 4 shown, the sample analyzer includes a pipetting device 110, a driving device 120, a reaction device 130, a detection device 140, a control device 150, and a sensing device 160.

[0135] The pipetting device 110 includes a power mechanism 111 and a pipetting needle 112. The power mechanism 111 is used to provide power for the pipetting needle 112 to suck and / or discharge liquid;

[0136] A sensing device 160, which is connected to the pipetting needle 112 and is used to obtain the pressure information and / or flow information of the liquid in the pipetting needle 112;

[0137] A driving device 120, which is used to drive the pipetting needle 112 to move;

[0138] A reaction device 130, which is used to process the liquid provided by the pipetting device 110 to obtain a test solution;

[0139] A detection device 140, which is used to detect the test solution;

[0140] The liquid suction / discharge operation of the sample analyzer includes: the driving device 120 drives the pipetting needle 112 to move horizontally to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism 111 controls the pipetting needle 112 to perform liquid suction / discharge at the liquid suction / discharge level, and after liquid suction / discharge, the driving device 120 drives the pipetting needle 112 to ascend to a second preset position and move horizontally away from the second preset position;

[0141] A control device 150, which is used to obtain the pressure information and / or flow information of the liquid in the pipetting needle 112 through the sensing device 160 during the liquid suction / discharge operation, and determine at least some of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move according to the pressure information and / or flow information of the liquid in the pipetting needle 112.

[0142] In some embodiments, the control device 150 is used to determine at least some of the movement parameters for the driving device 120 to drive the pipetting needle 112 to move according to at least one of the following pressure information and / or flow information:

[0143] The pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 sucks liquid at the liquid suction level;

[0144] The pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 ascends from the liquid suction level to a second preset position above the liquid suction level;

[0145] The pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 moves horizontally away from the second preset position above the liquid suction level;

[0146] The pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 descends from a first preset position above the liquid discharge level to the liquid discharge level.

[0147] Exemplarily, the control device 150 is configured to determine at least one of the following motion parameters based on the pressure information and / or flow information of the liquid in the pipetting needle 112 when the pipetting needle 112 aspirates liquid at the aspiration level:

[0148] At least some of the motion parameters of the driving device 120 driving the pipetting needle 112 to move upward from the aspiration level to a second preset position above the aspiration level;

[0149] At least some of the motion parameters of the driving device 120 driving the pipetting needle 112 to move horizontally away from the second preset position;

[0150] At least some of the motion parameters of the driving device 120 driving the pipetting needle 112 to move horizontally to a first preset position above the discharge level;

[0151] At least some of the motion parameters of the driving device 120 driving the pipetting needle 112 to move downward from the first preset position to the discharge level.

[0152] In some embodiments, the pressure information of the liquid in the pipetting needle 112 includes at least one of the following: pressure magnitude, pressure change rate; and / or

[0153] The flow information of the liquid in the pipetting needle 112 includes at least one of the following: flow velocity magnitude, flow rate magnitude, flow velocity change rate;

[0154] Wherein, when determining at least some of the motion parameters of the driving device 120 driving the pipetting needle 112 to move according to the pressure information and / or flow information of the liquid in the pipetting needle 112:

[0155] The velocity and / or acceleration of the pipetting needle 112 moving is negatively correlated with at least one of the following information: flow velocity magnitude, pressure change rate, flow velocity change rate; and / or

[0156] The velocity and / or acceleration of the pipetting needle 112 moving is positively correlated with at least one of the following information: pressure magnitude, flow rate magnitude.

[0157] A sample analyzer provided by an embodiment of the present application can control the driving device to drive the pipetting needle to move with different motion parameters according to the pressure information and / or flow information of the liquid in the pipetting needle, that is, the current working conditions of the pipetting needle, so that the movement of the pipetting needle can adapt to different working conditions, and the states of the liquid in the pipetting needle, isolated air and other fluids are more stable, so as to improve the accuracy and efficiency of the liquid volume aspirated / discharged.

[0158] Please refer to the foregoing embodiments in conjunction with Figure 6 , Figure 6 which is a schematic flowchart of a control method of a sample analyzer provided by an embodiment of the present application.

[0159] As shown in Figure 6As shown, the control method of the sample analyzer includes the following step S210.

[0160] Step S210: During the liquid suction / discharge operation of the sample analyzer, the driving device drives the pipetting needle to move horizontally to a first preset position and then move downward to the liquid suction / discharge level at the first preset position. The power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to move upward to a second preset position and leave the second preset position.

[0161] Wherein, during the liquid suction / discharge operation, pressure information and / or flow information of the liquid in the pipetting needle are obtained, and at least some motion parameters of the driving device driving the pipetting needle to move are determined according to the pressure information and / or flow information of the liquid in the pipetting needle.

[0162] In some embodiments, at least some motion parameters of the driving device driving the pipetting needle to move can be determined according to at least one of the following pressure information and / or flow information:

[0163] The pressure information and / or flow information of the liquid in the pipetting needle when the pipetting needle sucks liquid at the liquid suction level;

[0164] The pressure information and / or flow information of the liquid in the pipetting needle when the pipetting needle moves upward from the liquid suction level to a second preset position above the liquid suction level;

[0165] The pressure information and / or flow information of the liquid in the pipetting needle when the pipetting needle moves horizontally away from the second preset position above the liquid suction level;

[0166] The pressure information and / or flow information of the liquid in the pipetting needle when the pipetting needle moves downward from a first preset position above the liquid discharge level to the liquid discharge level.

[0167] Exemplarily, at least one of the following motion parameters can be determined according to the pressure information and / or flow information of the liquid in the pipetting needle when the pipetting needle sucks liquid at the liquid suction level:

[0168] At least some motion parameters of the driving device driving the pipetting needle to move upward from the liquid suction level to a second preset position above the liquid suction level;

[0169] At least some motion parameters of the driving device driving the pipetting needle to move horizontally away from the second preset position;

[0170] At least some motion parameters of the driving device driving the pipetting needle to move horizontally to a first preset position above the liquid discharge level;

[0171] The driving device drives the pipetting needle to move downward from the first preset position to at least part of the movement parameters at the liquid discharging position.

[0172] Optionally, the pressure information of the liquid in the pipetting needle includes at least one of the following: pressure magnitude, pressure change rate; and / or the flow information of the liquid in the pipetting needle includes at least one of the following: flow velocity magnitude, flow rate magnitude, flow velocity change rate.

[0173] Exemplarily, the speed and / or acceleration of the movement of the pipetting needle is negatively correlated with at least one of the following information: flow velocity magnitude, pressure change rate, flow velocity change rate; and / or the speed and / or acceleration of the movement of the pipetting needle is positively correlated with at least one of the following information: pressure magnitude, flow rate magnitude.

[0174] The specific principle and implementation manner of the control method of the sample analyzer provided in the embodiments of the present application are similar to those of the sample analyzer in the foregoing embodiments, and will not be elaborated here.

[0175] It should be understood that the terms used in the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0176] It should also be understood that the term "and / or" used in the present application and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0177] The above is only the specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should be covered within the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A sample analyzer, characterized in that, Comprising: A pipetting device, the pipetting device including a power mechanism and a pipetting needle, the power mechanism being used to provide power for the pipetting needle to aspirate and / or discharge liquid; A driving device, the driving device being used to drive the pipetting needle to move; A reaction device, the reaction device being used to process the liquid provided by the pipetting device to obtain a test solution; A detection device, the detection device being used to detect the test solution; The liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to horizontally move to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to ascend to a second preset position and horizontally move away from the second preset position; wherein, when there are at least two times that the liquid volumes of the liquid suction / discharge in the liquid suction / discharge operation process are different, at least some of the movement parameters of the driving device driving the pipetting needle to move are different.

2. The sample analyzer according to claim 1, wherein The speed of the driving device driving the pipetting needle to move corresponding to the liquid volume of the first liquid volume during the liquid suction / discharge operation process is less than the speed of the driving device driving the pipetting needle to move corresponding to the liquid volume of the second liquid volume during the liquid suction / discharge operation process; and / or The acceleration of the driving device driving the pipetting needle to move corresponding to the liquid volume of the first liquid volume during the liquid suction / discharge operation process is less than the acceleration of the driving device driving the pipetting needle to move corresponding to the liquid volume of the second liquid volume during the liquid suction / discharge operation process; wherein, the first liquid volume is less than the second liquid volume.

3. The sample analyzer according to claim 1 or 2, characterized in that, During at least two liquid suction operations, the movement parameters of the driving device driving the pipetting needle to ascend to the second preset position are different, and / or the movement parameters of the driving device driving the pipetting needle to horizontally move away from the second preset position are different.

4. The sample analyzer according to claim 1 or 2, characterized in that, During at least two liquid discharge operations, the movement parameters of the driving device driving the pipetting needle to horizontally move to the first preset position are different, and / or the movement parameters of the driving device driving the pipetting needle to descend to the liquid discharge level at the first preset position are different.

5. The sample analyzer according to claim 1 or 2, characterized in that, During the process that the driving device drives the pipetting needle to horizontally move to a first preset position above the liquid suction level and / or descend to the liquid suction level at the first preset position, the power mechanism controls the pipetting needle to aspirate and isolate air; During at least two liquid suction operations, the movement parameters of the driving device driving the pipetting needle to horizontally move to the first preset position above the liquid suction level are different, and / or the movement parameters of the driving device driving the pipetting needle to descend to the liquid suction level at the first preset position are different.

6. The sample analyzer according to any one of claims 1-5, characterized in that, The sample analyzer further includes a control device, the control device being used to determine at least some of the movement parameters of the driving device driving the pipetting needle to move during the liquid suction / discharge operation according to the detection item parameters of the sample corresponding to the liquid suction / discharge operation.

7. The sample analyzer according to any one of claims 1-5, characterized in that, The sample analyzer further includes a control device, which is configured to determine at least some of the motion parameters of the driving device driving the pipetting needle during the liquid suction / discharge operation according to the liquid parameters of the liquid corresponding to the liquid suction / discharge operation; The liquid parameters include at least one of the following: the volume of the liquid, the type of the liquid, and the physical property parameters of the liquid.

8. The sample analyzer according to any one of claims 1-5, characterized in that, The sample analyzer further includes a sensing device and a control device, the sensing device is connected to the pipetting needle and is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle; The control device is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle through the sensing device during the liquid suction / discharge operation, and determine at least some of the motion parameters of the driving device driving the pipetting needle according to the pressure information and / or flow information of the liquid in the pipetting needle.

9. The sample analyzer according to claim 8, characterized in that, The pressure information of the liquid in the pipetting needle includes at least one of the following: the magnitude of the pressure, the rate of change of the pressure; and / or The flow information of the liquid in the pipetting needle includes at least one of the following: the magnitude of the flow rate, the magnitude of the flow rate, the rate of change of the flow rate.

10. The sample analyzer according to claim 9, characterized in that, When determining at least some of the motion parameters of the driving device driving the pipetting needle according to the pressure information and / or flow information of the liquid in the pipetting needle: The speed and / or acceleration of the pipetting needle movement is negatively correlated with at least one of the following information: the magnitude of the flow rate, the rate of change of the pressure, the rate of change of the flow rate; and / or The speed and / or acceleration of the pipetting needle movement is positively correlated with at least one of the following information: the magnitude of the pressure, the magnitude of the flow rate.

11. A sample analyzer, characterized in that, including: A pipetting device, the pipetting device includes a power mechanism and a pipetting needle, and the power mechanism is configured to provide power for the pipetting needle to suck and / or discharge liquid; A sensing device, the sensing device is connected to the pipetting needle and is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle; A driving device, the driving device is configured to drive the pipetting needle to move; A reaction device, the reaction device is configured to process the liquid provided by the pipetting device to obtain a test solution; A detection device, the detection device is configured to detect the test solution; The liquid suction / discharge operation of the sample analyzer includes: the driving device drives the pipetting needle to move horizontally to a first preset position and descend to the liquid suction / discharge level at the first preset position, the power mechanism controls the pipetting needle to perform liquid suction / discharge at the liquid suction / discharge level, and after the liquid suction / discharge, the driving device drives the pipetting needle to rise to a second preset position and move horizontally away from the second preset position; A control device, the control device is configured to obtain the pressure information and / or flow information of the liquid in the pipetting needle through the sensing device during the liquid suction / discharge operation, and determine at least some of the motion parameters of the driving device driving the pipetting needle according to the pressure information and / or flow information of the liquid in the pipetting needle.

12. The sample analyzer according to claim 11, characterized in that, The control device is configured to determine at least some of the motion parameters of the driving device driving the pipetting needle according to at least one of the following pressure information and / or flow information: The pressure information and / or flow information of the liquid inside the pipetting needle when the pipetting needle aspirates liquid at the aspiration level; The pressure information and / or flow information of the liquid inside the pipetting needle when the pipetting needle moves upward from the aspiration level to a second preset position above the aspiration level; The pressure information and / or flow information of the liquid inside the pipetting needle when the pipetting needle moves horizontally away from the second preset position above the aspiration level; The pressure information and / or flow information of the liquid inside the pipetting needle when the pipetting needle moves downward from a first preset position above the discharge level to the discharge level.

13. The sample analyzer according to claim 12, wherein, The control device is used to determine at least one of the following motion parameters according to the pressure information and / or flow information of the liquid inside the pipetting needle when the pipetting needle aspirates liquid at the aspiration level: At least part of the motion parameters of the driving device driving the pipetting needle to move upward from the aspiration level to a second preset position above the aspiration level; At least part of the motion parameters of the driving device driving the pipetting needle to move horizontally away from the second preset position; At least part of the motion parameters of the driving device driving the pipetting needle to move horizontally to a first preset position above the discharge level; At least part of the motion parameters of the driving device driving the pipetting needle to move downward from the first preset position to the discharge level.

14. The sample analyzer according to any one of claims 11-13, wherein The pressure information of the liquid inside the pipetting needle includes at least one of the following: pressure magnitude, pressure change rate; and / or The flow information of the liquid inside the pipetting needle includes at least one of the following: flow velocity magnitude, flow rate magnitude, flow velocity change rate; Wherein, when determining at least part of the motion parameters of the driving device driving the pipetting needle to move according to the pressure information and / or flow information of the liquid inside the pipetting needle: The speed and / or acceleration of the pipetting needle movement is negatively correlated with at least one of the following information: flow velocity magnitude, pressure change rate, flow velocity change rate; and / or The speed and / or acceleration of the pipetting needle movement is positively correlated with at least one of the following information: pressure magnitude, flow rate magnitude.

15. A control method for a sample analyzer, characterized in that, Including: During the aspiration / discharge operation of the sample analyzer, the driving device drives the pipetting needle to move horizontally to a first preset position and move downward from the first preset position to the aspiration / discharge level, the power mechanism controls the pipetting needle to aspirate / discharge liquid at the aspiration / discharge level, and after aspiration / discharge, the driving device drives the pipetting needle to move upward to a second preset position and leave the second preset position; Wherein, when there are at least two times when the liquid volumes aspirated / discharged during the aspiration / discharge operation are different, at least part of the motion parameters of the driving device driving the pipetting needle to move are different.

16. A control method for a sample analyzer, characterized in that, Including: During the aspiration / discharge operation of the sample analyzer, the driving device drives the pipetting needle to move horizontally to a first preset position and move downward from the first preset position to the aspiration / discharge level, the power mechanism controls the pipetting needle to aspirate / discharge liquid at the aspiration / discharge level, and after aspiration / discharge, the driving device drives the pipetting needle to move upward to a second preset position and leave the second preset position; Wherein, during the liquid suction / discharge operation, pressure information and / or flow information of the liquid in the pipetting needle is acquired, and at least some motion parameters of the driving device for driving the pipetting needle to move are determined based on the pressure information and / or flow information of the liquid in the pipetting needle.

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