Medicament administration device

Abstract

A drug administration instrument (1) is provided with a holding member (30) that binds and holds a plurality of autoinjectors (5), the holding member (30) is provided with a housing holding part (31), a cap covering part (32), and a breakable connecting part (33), and the housing holding part (31) and the cap covering part (32) are separated by breaking the breakable connecting part (33). The separated case holding section (31) holds the plurality of autoinjector bodies (50) while maintaining a state in which the plurality of autoinjector bodies (50) are bundled, and the separated cap covering section (32) can be separated from the drug administration instrument (1) simultaneously with the plurality of caps (56), or only the separated cap covering section (32) can be separated from the drug administration instrument (1).

Description

Technical Field

[0001] The present invention relates to a medicament administration device including a plurality of autoinjectors and a holding member that bundles and holds the plurality of autoinjectors. Background Art

[0002] Conventionally, a device (autoinjector) for automatically or semi-automatically injecting (administering) a medicament (medical liquid or the like) has been known. Such an autoinjector, for example, as disclosed in Patent Document 1 (Japanese Patent Application Laid-Open No. 2015-533562), releases a drive mechanism (90) for delivering a certain amount of medicament by a prescribed operation, and releases the medicament in a medicament container (24) via a delivery member (28).

[0003] Autoinjectors are standardized to a certain extent according to the type and use of the medicament. Therefore, depending on the patient, it may be necessary to use a plurality of autoinjectors to administer the medicament according to the appropriate dosage of the medicament.

[0004] Patent Document 1: Japanese Patent Application Laid-Open No. 2015-533562 (WO2014-053451A, US2015-273162A, EP2903670A)

[0005] When using a plurality of autoinjectors to administer a medicament, the preparation for administration also requires a great deal of effort. For a plurality of autoinjectors, it is necessary to unpack them separately, remove the caps, and then, if necessary, attach the plurality of autoinjectors to an auxiliary tool for simultaneous administration, which requires a great deal of effort. In addition, the cap attached to the front end portion of the autoinjector is effective for preventing external contact with the injection needle or the like in the state before use, and for improving the safety of the autoinjector. Here, it is difficult to balance making the cap difficult to come off for improving safety and making the cap easy to remove for reducing the effort of administration preparation. Summary of the Invention

[0006] Therefore, an object of the present invention is to provide a medicament administration device including a plurality of autoinjectors and a holding member that bundles and holds the plurality of autoinjectors, which can reduce the effort of administration preparation and has high safety in the state before use.

[0007] The above object can be achieved as follows.

[0008] (1) A medicament administration device including a plurality of autoinjectors and a holding member that bundles and holds the plurality of autoinjectors, wherein the autoinjector includes: an autoinjector main body that houses a prefilled syringe and a seal pressing mechanism in a cylindrical housing; and a cap that is removably attached to the front end portion of the autoinjector main body, and

[0009] The holding member includes: a housing holding portion that holds the housings of the plurality of auto-injectors; a cap covering portion that covers the caps of the plurality of auto-injectors; and a breakable connection portion that separably connects the housing holding portion and the cap covering portion.

[0010] By breaking the breakable connection portion, the housing holding portion is separated from the cap covering portion, and the separated housing holding portion maintains a state of bundling and holding the plurality of auto-injector bodies. In addition, the separated cap covering portion can be detached from the medicament administration device simultaneously with the plurality of caps, or only the separated cap covering portion can be detached from the medicament administration device.

[0011] In addition, the above-described embodiment may also be the following manner.

[0012] (2) The medicament administration device according to (1) above, wherein

[0013] The separated cap covering portion can be detached from the medicament administration device simultaneously with the plurality of caps.

[0014] (3) The medicament administration device according to (1) or (2) above, wherein

[0015] The holding member is a thin film member.

[0016] (4) The medicament administration device according to (3) above, wherein

[0017] The thin film member is a heat-shrinkable thin film member.

[0018] (5) The medicament administration device according to any one of (1) to (4) above, wherein

[0019] The holding member is a single thin film-like packaging member,

[0020] The breakable connection portion is a linear or strip-shaped breakable portion provided on the holding member.

[0021] (6) The medicament administration device according to (5) above, wherein

[0022] The breakable portion is formed by intermittent and linearly extending cuts or thin wall portions, and does not penetrate the holding member.

[0023] (7) The medicament administration device according to (5) or (6) above, wherein

[0024] The breakable connection portion is a strip-shaped breakable portion provided on the holding member, and the breakable portion has a break start portion extending in the width direction of the breakable portion.

[0025] (8) The medicament administration device according to (7) above, wherein,

[0026] The fracture starting portion is formed by a cut or a thin-walled portion that is intermittent and linearly extends along the width direction of the frangible portion.

[0027] (9) The medicament administration device according to (7) or (8) above, wherein,

[0028] It has a gripping fin, one end of which is fixed to the frangible portion and the other end is a free end, and the one end of the gripping fin is fixed at a position close to the fracture starting portion.

[0029] (10) The medicament administration device according to any one of (1) to (9) above, wherein,

[0030] It has a separation member that is disposed between the housings of two adjacent automatic syringes and is used to maintain the automatic syringe bodies of the two adjacent automatic syringes in a separated state from each other.

[0031] (11) The medicament administration device according to (10) above, wherein,

[0032] The housing holding portion is a film-like packaging member,

[0033] The housing holding portion covers the outer peripheries of the housings of the two adjacent automatic syringes in which the separation member is disposed, and maintains the automatic syringe bodies of the two adjacent automatic syringes in a separated state from each other and in a side-by-side state.

[0034] (12) The medicament administration device according to any one of (1) to (11) above, wherein,

[0035] The cap covering portion is a film-like packaging member that covers the outer peripheries of the caps of two adjacent automatic syringes, and within the cap covering portion, the caps of the two adjacent automatic syringes are in contact with each other. Description of the Drawings

[0036] Figure 1 It is a front view showing an embodiment of the medicament administration device of the present invention.

[0037] Figure 2 It is showing from Figure 1 The front view of the state after removing the holding member from the shown medicament administration device.

[0038] Figure 3 It is Figure 1 The A-A cross-sectional view of.

[0039] Figure 4 It is Figure 1 The B-B cross-sectional view of.

[0040] Figure 5 This is a front view showing an example of an auto-injector used in the medicament administration device of the present invention.

[0041] Figure 6 This is used to illustrate Figure 5 the state after medicament administration is completed in the auto-injector shown.

[0042] Figure 7 This is used to illustrate Figure 1 the usage method of the medicament administration device shown.

[0043] Figure 8 This is used to illustrate Figure 1 the usage method of the medicament administration device shown.

[0044] Figure 9 This is used to illustrate Figure 1 the usage method of the medicament administration device shown.

[0045] Figure 10 This is used to illustrate Figure 1 the usage method of the medicament administration device shown.

[0046] Figure 11 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0047] Figure 12 This is used to illustrate Figure 11 the usage method of the medicament administration device shown.

[0048] Figure 13 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0049] Figure 14 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0050] Figure 15 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0051] Figure 16 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0052] Figure 17 This is a front view showing another embodiment of the medicament administration device of the present invention.

[0053] Figure 18 This is Figure 17 a sectional view taken along line C-C of

[0054] Figure 19 is Figure 17 a D-D sectional view of

[0055] Figure 20 is a front view showing another embodiment of the medicament administration device of the present invention.

[0056] Figure 21 is a front view showing another embodiment of the medicament administration device of the present invention. Detailed Description

[0057] The medicament administration device of the present invention will be described using the embodiments shown in the drawings.

[0058] The medicament administration device 1 of the present invention is a medicament administration device 1 including a plurality (two in this case) of autoinjectors 5 and a holding member 30 that bundles and holds the plurality of autoinjectors 5. The autoinjector 5 includes: an autoinjector main body 50 that houses a prefilled syringe 52 and a gasket pressing mechanism 53 in a cylindrical housing 51; and a cap 56 that is detachably attached to the front end portion of the autoinjector main body 50. The holding member 30 includes: a housing holding portion 31 that holds the housings 51 of the plurality of autoinjectors 5; a cap covering portion 32 that covers the caps 56 of the plurality of autoinjectors 5; and a frangible connecting portion 33 that detachably connects the housing holding portion 31 and the cap covering portion 32. By breaking the frangible connecting portion 33, the housing holding portion 31 and the cap covering portion 32 are separated, and the separated housing holding portion 31 maintains the state of bundling and holding the plurality of autoinjector main bodies 50. In addition, the separated cap covering portion 32 can be detached from the medicament administration device simultaneously with the plurality of caps 56, or only the separated cap covering portion 32 can be detached from the medicament administration device.

[0059] Here, first, an outline of the autoinjector used in the medicament administration device 1 of the present embodiment will be described using the embodiments shown in the drawings. As the autoinjector, various known autoinjectors can be used. Here, for the autoinjector 5, descriptions other than the specified structure are omitted. The autoinjector 5 of the present embodiment includes: an autoinjector main body 50 that houses a prefilled syringe 52 and a gasket pressing mechanism 53 in a cylindrical housing 51; and a cap 56 that is detachably attached to the front end portion of the autoinjector main body 50.

[0060] The housing 51 of the autoinjector 5 (autoinjector main body 50) is made of a hard or semi-hard resin and, as shown in Figure 1 and Figure 3 is a cylindrical member having a substantially hexagonal cross-section orthogonal to the axial direction. In addition, as the shape of the cross-section orthogonal to the axial direction of the housing of the autoinjector main body 50, in addition to the illustrated shape, there are also a circular shape, a rounded polygonal shape, and a shape in which each side of a rounded quadrilateral is bent outward.

[0061] The end on one axial side of the housing 51 of the auto-injector body 50 ( Figure 5 the upper end in it) is closed. The end on the other axial side of the housing 51 ( Figure 5 the lower end in it) is open, as Figure 5 and Figure 6 shown, a pressing part 55 (needle shield) protruding from the housing 51 is provided. The pressing part 55 can move relative to the housing 51 within a specified range. As Figure 5 shown, a cap 56 is detachably mounted on the front end part of the auto-injector body 50, and this cap 56 is used to prevent external contact with the pressing part 55 and the injection needle 61 in the state before use.

[0062] In the present embodiment, as Figure 5 shown, the outer shape (outer diameter) of the cap 56 is larger than the outer shape of the front end part of the auto-injector body 50. In other words, when the auto-injector 5 is viewed from the front, the width direction dimension of the cap 56 part ( Figure 5 the dimension in the left-right direction in it) is larger than the width direction dimension of the auto-injector body 50, and the side part of the cap 56 protrudes outward. In this embodiment, as Figure 4 shown, the cap 56 becomes a cylindrical member with a circular cross-section and a closed front end. Moreover, the whole of the tubular side surface of the cap 56 is larger than the whole of the tubular side surface of the auto-injector body 50, and the whole side part of the cap 56 protrudes outward.

[0063] The auto-injector 5 is provided with a window part 57 formed on the side wall part of the housing 51 for visually confirming the inside of the prefilled syringe 52. An auto-injector usually has a window part capable of visually confirming the movement of the gasket accommodated inside the prefilled syringe, specifically, inside the prefilled syringe. By confirming the movement of the gasket from this window part, the progress and end of the administration of the medicine (medical liquid) are grasped.

[0064] The window portion 57 of the auto-injector 5 is a through-hole formed in the side wall portion of the housing 51 and having a substantially rectangular shape. Thereby, the interior of the housing 51 can be visually confirmed from the outside of the auto-injector 5 via the window portion 57. The window portion 57 is formed in the front-end side portion of the auto-injector 5. Thereby, the interior of the prefilled syringe 52 housed in the housing 51 (more specifically, the movement of the gasket 59 within the prefilled syringe 52) can be visually confirmed from the outside of the auto-injector 5 via the window portion 57. Although not shown, the window portions 57 are preferably formed on two opposed surfaces of the side wall portion of the housing 51, respectively. In addition, the shape, formation position, and number of the window portions are not limited to the illustrated shape, formation position, and number. For example, the window portion may be one or three or more, but is at least formed on the opposed surfaces (portions) of the side wall portion of the housing, and is preferable from the viewpoint of visibility of the interior of the prefilled syringe via the window portion.

[0065] The prefilled syringe 52 is housed inside the housing 51. The prefilled syringe 52 includes an outer cylinder 58, a gasket 59 housed within the outer cylinder 58 and capable of sliding in a liquid-tight state, and a medicament (medical liquid) 60 filled into the outer cylinder 58.

[0066] The outer cylinder 58 is a transparent or semi-transparent cylindrical member. A flange portion protruding outward is formed at the base end portion ( Figure 5 the upper end portion in this case) of the outer cylinder 58 (outer cylinder main body portion). A nozzle portion having a reduced diameter toward the front end direction is formed at the front end portion ( Figure 5 the lower end portion in this case) of the outer cylinder 58, and a hollow metallic injection needle 61 is attached to the nozzle portion. The interior and exterior of the outer cylinder 58 communicate with each other via the injection needle 61. The tip of the injection needle 61 serves as a puncture tip. The outer cylinder 58 is housed (fixed) inside the housing 51 in a manner that it cannot move relative to the housing 51. As the material for forming the outer cylinder 58, glass, plastic, etc. can be used.

[0067] The gasket 59 is housed inside the outer cylinder 58 (outer cylinder main body portion). The gasket 59 can move while making liquid-tight contact with the inner surface of the outer cylinder 58. As the material for forming the gasket 59, rubber having elasticity is preferably used.

[0068] Inside the prefilled syringe 52, specifically inside the outer cylinder 58, a medical liquid 60 is filled in the space defined by the inner surface of the outer cylinder 58 and the gasket 59. As the medical liquid 60 filled into the prefilled syringe 52, for example, it is a solution, gel, or suspension containing a medicament. The medicament that can be used has no substantial limitation as long as it is not a medicament unsuitable for transdermal administration.

[0069] Examples of the medicament contained in the medical liquid include protein preparations, antibody preparations, hyaluronic acid, antibacterial agents, antiviral agents, vaccines, anti-tumor agents, immunosuppressive agents, steroid agents, anti-inflammatory agents, anti-rheumatic agents, arthritis therapeutic agents, antihistamines, anti-allergy agents, diabetes therapeutic agents, hormonal agents such as growth hormone, bone calcium metabolism agents, vitamins, blood preparations, hematopoietic agents, antithrombotic agents, antihyperlipidemic agents, antiarrhythmic agents, vasodilators, prostaglandins, calcium antagonists, ACE inhibitors, β-blockers, antihypertensive agents, diuretics, xanthine derivatives, β-agonists, anti-asthma agents, antitussives, expectorants, anticholinergic agents, antidiarrheal agents, stomachic digestive agents, anti-ulcer agents, laxatives, hypnotics, sedatives, antipyretics, cold remedies, antiepileptic agents, antipsychotic agents, antidepressants, anxiolytics, central nervous system stimulants, parasympathomimetic agents, sympathomimetic agents, antiemetics, central stimulants, anti-Parkinson's agents, muscle relaxants, antispasmodics, anesthetics, antipruritics, anti-migraine agents, oligonucleotides, gene drugs, and the like.

[0070] Inside the housing 51, a gasket pressing mechanism 53 is accommodated. Here, the detailed structure of the gasket pressing mechanism 53 is omitted, but for example, as Figure 5 and Figure 6 shown, the gasket pressing mechanism 53 includes a coil spring 62 capable of pressing the gasket 59. The coil spring 62 is pre-compressed and is restrained so as not to exert its acting force in the state before use of the auto-injector 5. The gasket pressing mechanism 53 starts to operate by a prescribed operation of the auto-injector 5 (the auto-injector 5 becomes a prescribed state), in other words, starts the pressing (applying force) of the coil spring 62 on the gasket 59, causing the gasket 59 to move in the outer cylinder 58 toward the front end direction of the prefilled syringe 52 (outer cylinder 58).

[0071] Here, the operation of the auto-injector 5 of this embodiment will be briefly described. When using the auto-injector 5, first, the cap 56 is removed from the auto-injector 5. Next, the housing 51 is held, and the pushing portion 55 is pushed against the administration site 70, causing the housing 51 to advance toward the administration site 70. Thereby, as Figure 6As shown, the pressing part 55 moves inside the housing 51, and the injection needle 61 protrudes (projects) from the pressing part 55, and the injection needle 61 punctures the administration site 70. By this operation (the pressing part 55 enters the housing 51 by a prescribed amount), the gasket pressing mechanism 53 starts to operate. In a state where the injection needle 61 punctures the administration site 70, the gasket 59 is moved toward the front end direction of the prefilled syringe 52 (outer cylinder 58) by the gasket pressing mechanism 53 (coil spring 62), whereby the medical liquid 60 is released from the injection needle 61 and the medical liquid 60 is administered to the patient. Further, after the medical liquid 60 is administered, the pressing of the auto-injector 5 against the administration site 70 is released, and the housing 51 is retracted, whereby the pressing part 55 returns to the state before use, and the injection needle 61 is again housed inside the housing 51 (pressing part 55).

[0072] The auto-injector 5 of the present embodiment is a so-called two-step auto-injector that automatically starts the operation of the gasket pressing mechanism 53 and administers the medical liquid 60 to the patient by advancing the housing 51 in a state where the pressing part 55 is pressed against the administration site 70 (the pressing part 55 enters the housing 51 by a prescribed amount). Further, the auto-injector may be a so-called three-step auto-injector that starts the operation of the gasket pressing mechanism by a prescribed operation (for example, pressing a separately provided operation start button) in a state where the injection needle punctures the administration site 70 of the patient.

[0073] The medicament administration device 1 of the present embodiment includes a plurality (two in this case) of auto-injectors 5, and includes a holding member 30 that bundles and holds these plurality of auto-injectors 5.

[0074] In the present embodiment, as shown in Figure 1 、 Figure 3 and Figure 4 , the holding member 30 is formed of a film member. Further, the holding member 30 also functions as a packaging member. The holding member 30 is formed of a film member and is closely attached to the auto-injector, whereby the outer shape of the medicament administration device 1 including the holding member 30 can be reduced. Here, the film member refers to a thin-walled member, and various known film members can be used.

[0075] Further, as a constituent material of the holding member 30 (film member), a material having heat shrinkability is preferably used. Examples of the material of the holding member 30 (film member) include polyesters such as polyethylene terephthalate and polybutylene terephthalate, polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polystyrene, or polymer alloys containing them.

[0076] The film member can be a single-layer film member, or a laminated film member composed of multiple layers with different constituent materials can also be used. In addition, the constituent material and thickness of the film member are not particularly limited. The film member preferably has transparency that enables visual confirmation of the autoinjector from the outside of the medicament delivery device.

[0077] In addition, the holding member 30 (film member) can also be an extended film formed by extending the film formed of the above material. Furthermore, the holding member 30 (film member) can also be a heat-shrinkable cylindrical body formed of the above material.

[0078] In the present embodiment, the film member constituting the holding member 30 preferably uses a cylindrical body composed of a heat-shrinkable film member. A heat-shrinkable film member is a film member having the property of shrinking when heated. A heat-shrinkable film member is sometimes also referred to as a shrink film member. The heat-shrinkable film member shrinks by heating in a state of wrapping the object to be packaged, and closely adheres to the outer surface of the object to be packaged (covers the outer periphery of the object to be packaged).

[0079] In the present embodiment, the holding member 30 is formed of a single film-like packaging member. In other words, in the present embodiment, the holding member 30 is a film-like packaging member composed of a single cylindrical heat-shrinkable film member, which covers the outer peripheries of a plurality of (two in the present embodiment) autoinjectors 5 having caps 56, adheres closely to them, and packages them. The medicament delivery device 1 can operate in a state where a plurality of autoinjectors 5 are packaged (held) by the holding member 30 which is a film-like packaging member. The holding member as the film-like packaging member preferably has transparency that enables visual confirmation of the autoinjector from the outside of the medicament delivery device, but details indicating the autoinjector (for example, drug name, drug dose) can also be printed on a part thereof for display.

[0080] The holding member 30 includes a housing holding portion 31 for holding the housing 51 of a plurality of autoinjectors 5. Here, the portion of the holding member (film-like packaging member) 30 that covers the outer peripheries of the housings 51, 51 of two adjacent autoinjectors 5, 5 constitutes the housing holding portion 31. In the present embodiment, as Figure 1 shown, the housing holding portion 31 does not cover the base end portion of the housing 51 of the autoinjector 5, but is not limited to such a manner, and the housing holding portion may also cover the base end portion of the housing of the autoinjector.

[0081] In the present embodiment, as Figure 1 and Figure 2 shown, between the housings 51, 51 of two adjacent autoinjectors 5, 5, a separating member 40 for maintaining the autoinjector bodies 50, 50 of the two adjacent autoinjectors 5, 5 in a mutually separated state is disposed.

[0082] Specifically, the isolation member 40 has a prescribed thickness and extends in a prescribed length along the axial direction of the autoinjector 5 ( Figure 1 the up-and-down direction in

[0083] ). By means of the isolation member 40, it is possible to maintain a prescribed interval between two adjacent autoinjectors 5, 5, particularly between the injection needles 61, 61 of the autoinjectors 5, 5. Thereby, it is possible to prevent the administration sites (injection sites) of the medical liquid using multiple autoinjectors from becoming too close to each other.

[0084] In addition, in the present embodiment, as described above, the outer shape (outer diameter) of the cap 56 is larger than the outer shape of the front end portion of the autoinjector main body 50. When two adjacent autoinjector main bodies 50, 50 are in a juxtaposed state (a state where the axes are parallel), the caps 56, 56 abut against each other, and a gap is formed between the housings 51, 51 of the autoinjectors 5, 5. The isolation member 40 preferably fills this gap. In addition, the isolation member 40 preferably maintains two adjacent autoinjectors 5, 5 in a substantially parallel state with the caps 56 mounted. In addition, the isolation member 40 preferably maintains the injection needles 61, 61 of two adjacent autoinjectors 5, 5 in a substantially parallel state when the caps 56 are removed. Figure 3 The isolation member 40 has a side portion shape corresponding to the outer shape of the housing 51 of the autoinjector 5. Here, as

[0085] shown, in a cross section orthogonal to the axial direction, corresponding to the outer shape (corners) of the substantially hexagonal cylindrical housing 51, the isolation member 40 has a shape with a recessed central portion. In addition, the side portion shape of the isolation member can be appropriately set corresponding to the outer shape of the housing of the autoinjector. Figure 3 As

[0086] shown, a plurality of protrusions 41 (four in this case) are formed on the side portion of the isolation member 40. In the present embodiment, the protrusions 41 formed on the side portion of the isolation member 40 each become ribs that protrude outward in a substantially semicircular cross-sectional shape and extend over the entire axial length of the isolation member 40. In a state where the isolation member 40 is disposed between the housings 51, 51 of two adjacent autoinjectors 5, 5, each protrusion 41 abuts against the outer surface of the autoinjector 5 (housing 51). In addition, the form of the protrusions formed on the side portion of the isolation member is not limited to the above. For example, it may also be a plurality of substantially hemispherical protrusions or the like.

[0087] In the present embodiment, the housing holding portion 31 is a film-like package (a part of a film-like package constituting the holding member 30), and the housing holding portion 31 covers the outer peripheries of the housings 51, 51 of two adjacent auto-injectors 5, 5 in which the isolation member 40 is disposed, and maintains the auto-injector bodies 50, 50 of the two adjacent auto-injectors 5, 5 in a separated and juxtaposed state (a state where the axes are parallel). Thus, the isolation member 40 and the holding member 30 (the housing holding portion 31) cooperate to be able to maintain the auto-injector bodies 50, 50 of the two adjacent auto-injectors 5, 5 in a separated state without shaking.

[0088] The holding member 30 includes a cap covering portion 32 that covers the caps 56 of a plurality of auto-injectors 5. Here, the portion of the holding member (film-like package) 30 that covers the outer peripheries of the caps 56, 56 of two adjacent auto-injectors 5, 5 becomes the cap covering portion 32. In the present embodiment, as Figure 1 shown, the cap covering portion 32 covers the front end portion (front end opening) of the cap 56, but is not limited to such a manner, and the cap covering portion may not cover the front end portion of the cap, or the front end may not be open (closed).

[0089] In the present embodiment, the cap covering portion 32 is a film-like package (a part of a single film-like package constituting the holding member 30), covers the outer peripheries of the caps 56, 56 of two adjacent auto-injectors 5, 5, and the caps 56, 56 of the two adjacent auto-injectors 5, 5 abut within the cap covering portion 32.

[0090] Specifically, in the present embodiment, as Figure 4 shown, the outer shape of the cap 56 is substantially cylindrical, and when the auto-injector bodies 50, 50 of two adjacent auto-injectors 5, 5 are in a juxtaposed state (a state where the axes are parallel), the outer peripheral surfaces of the two caps 56, 56 abut (are in close contact) linearly (linearly along the axial direction). Thus, the holding member 30 (the cap covering portion 32) can hold (cover) the caps 56, 56 of two adjacent auto-injectors 5, 5 without shaking. In addition, as will be described later, it is easy to separate the separated cap covering portion 32 and the plurality of caps 56 from the medicament administration device 1 at the same time.

[0091] In the present embodiment, as described above, the outer shape (outer diameter) of the cap 56 is larger than the outer shape of the front end portion of the auto-injector body 50, and in the holding member 30, as Figure 1As shown, a reduced-diameter portion 34 is formed at the upper part of the cap covering portion 32. More specifically, the holding member 30 is composed of a tubular heat-shrinkable film member that covers the outer periphery of the autoinjector 5 and is in close contact with them. A reduced-diameter portion 34 with a smaller outer shape upward is formed at the upper part of the cap covering portion 32. Thereby, the cap covering portion 32 covers the cap 56 more firmly. In addition, as described later, it is easy to separate the separated cap covering portion 32 and a plurality of caps 56 from the medicament administration device 1 at the same time.

[0092] The holding member 30 includes a breakable connection portion 33 that detachably connects the housing holding portion 31 and the cap covering portion 32. Here, the holding member 30 is a thin-film packaging member (in other words, a single integrated object), and the breakable connection portion 33 is a breakable linear or strip-shaped portion provided on the holding member 30. In other words, with the breakable connection portion (breakable portion) 33 as a boundary, the upper part of the holding member 30 becomes the housing holding portion 31, and the lower part becomes the cap covering portion 32.

[0093] In the present embodiment, the breakable connection portion (breakable portion) 33 is provided over the entire circumference of the holding member 30. The breakable portion 33 includes: a first breakable linear portion 35 that extends over substantially the entire length (entire circumference) of the breakable portion 33; and a second breakable linear portion 36 that is opposed to (substantially parallel in the present embodiment) the first breakable linear portion 35 and extends over substantially the entire length (entire circumference) of the breakable portion 33. In other words, a strip-shaped breakable portion 33 is formed on the holding member 30 by the first breakable linear portion 35 and the second breakable linear portion 36 that extend in an opposed manner (substantially parallel in the present embodiment).

[0094] In the present embodiment, as Figure 1 shown, in the axial direction of the autoinjector 5, the second breakable linear portion 36 is located above the base end portion of the cap 56 (the front end portion of the housing 51). Thereby, the above-mentioned reduced-diameter portion 34 is formed at the upper part of the cap covering portion 32. In addition, the first breakable linear portion 35 is located above the second breakable linear portion 36 and below the lower end of the window portion 57 formed in the autoinjector main body 50.

[0095] The breakable portion 33 is preferably formed by intermittent and linearly extending cuts or thin-wall portions and does not penetrate the holding member 30. In the present embodiment, the first breakable linear portion 35 and the second breakable linear portion 36 are formed on the holding member 30 in an intermittent and linearly extending manner and are cuts (so-called semi-cut portions) that do not penetrate the holding member 30, and have lower strength (are easier to break) compared to other parts of the holding member 30 (parts where the first breakable linear portion 35 and the second breakable linear portion 36 are not formed).

[0096] Since the breakable linear portions 35 and 36 do not penetrate the holding member (film-like packaging) 30, it is possible to prevent the breakable connecting portion (breakable portion) 33 from accidentally breaking (the housing holding portion 31 and the cap covering portion 32 separating) in the state before use of the medicament administration device 1, making it difficult for the cap 56 to fall off the autoinjector 5, and improving safety. In addition, it is possible to prevent foreign matter from entering the medicament administration device 1 through the breakable connecting portion (breakable portion) 33.

[0097] In addition, in the above-described embodiment, the breakable portion (first breakable linear portion and second breakable linear portion) is formed by intermittently and linearly extending incisions, but is not limited thereto. The breakable portion (breakable linear portion) may be formed, for example, by a perforated line, a crease, intermittently formed dot portions, continuously formed thin wall portions, or the like.

[0098] As described above, the breakable connecting portion 33 of the present embodiment is a strip-shaped breakable portion 33 provided in the holding member 30, and the breakable portion 33 includes a fracture initiation portion 37 extending in the width direction of the breakable portion 33. Moreover, the fracture initiation portion 37 is preferably formed by an incision or a thin wall portion that intermittently and linearly extends in the width direction of the breakable portion 33.

[0099] Specifically, as Figure 1 shown, the fracture initiation portion 37 of the holding member 30 is formed by an incision that intermittently and linearly extends in the width direction ( Figure 1 the vertical direction in Figure 1 ). In addition, as Figure 3 and

[0100] shown, the fracture initiation portion 37 is provided at a portion where the holding member 30 (breakable portion 33) is in close contact with the autoinjector main body 50 (housing 51). Thereby, it is easy to break the fracture initiation portion 37 (the breakable portion 33 starts to break) from the outside of the medicament administration device 1. In addition, the fracture initiation portion may be formed between two adjacent autoinjectors, at a portion where the holding member is not in contact with the autoinjector (and the isolation member). Use Figures 7 to 10 The operation when using the medicament administration device 1 as described above will be described. In addition, in Figures 7 to 10 , for the sake of explanation, the portion where the holding member (film-like packaging) exists is marked with cross hatching.

[0101] When using the medicament administration device 1, first, break the breakable connecting portion (breakable portion) 33 of the medicament administration device 1 shown in Figure 7 . Specifically, start breaking the breakable connecting portion (breakable portion) 33 from the fracture initiation portion 37, break the breakable connecting portion (breakable portion) 33 along the first breakable linear portion 35 and the second breakable linear portion 36, and remove the breakable connecting portion (breakable portion) 33 of the holding member 30 from the medicament administration device 1. Thereby, asFigure 8 As shown, the housing holding part 31 is separated from the cap covering part 32.

[0102] Next, as Figure 9 shown, the separated cap covering part 32 and the plurality of caps 56 are simultaneously detached from the medicine administering device 1. Here, as described above, the second frangible linear part 36 of the medicine administering device 1 is located above the base end part (the front end part of the housing 51) of the cap 56, and a reduced diameter part 34 is formed in the upper part of the cap covering part 32. Thereby, the situation where only the separated cap covering part 32 accidentally detaches from the medicine administering device 1 is prevented, and furthermore, it is easy to simultaneously detach the separated cap covering part 32 and the plurality of caps 56 from the medicine administering device 1.

[0103] As Figure 9 shown, in the state where the cap covering part 32 (and the cap 56) is detached, the separated housing holding part 31 maintains the state of bundling and holding the plurality of auto-injector bodies 50. In the present embodiment, a separation member 40 is disposed between the housings 51, 51 of two adjacent auto-injectors 5, 5, and the housing holding part 31 covers the outer peripheries of the housings 51, 51 of the two adjacent auto-injectors 5, 5 where the separation member 40 is disposed, and maintains the auto-injector bodies 50, 50 of the two adjacent auto-injectors 5, 5 in a mutually separated and juxtaposed state (an axially parallel state). Thereby, the medicine (medical liquid) administration parts (injection parts) of the plurality of auto-injectors are maintained in a substantially parallel state, and it is possible to prevent the two from getting too close.

[0104] Then, as Figure 10 shown, in the state where the housing holding part 31 holds the plurality of auto-injectors 5, the pressing part 55 is pressed against the administration part 70, and the housing 51 is further advanced toward the administration part 70, thereby completing the administration of the medicine (medical liquid) 60.

[0105] In addition, in the present embodiment, the frangible part (frangible connecting part) 33 is in a band shape, and once the frangible part 33 is broken, it cannot be restored. Thereby, even when the cap 56 is reinstalled on the auto-injector body 50 after using the medicine administering device 1 (after administering the medical liquid), it is possible to visually confirm that the medicine administering device 1 has been opened.

[0106] Hereinafter, other embodiments of the medicine administering device of the present invention will be described with reference to the drawings. In addition, in the following description, for structures substantially the same as those of the above-mentioned medicine administering device 1, corresponding names and reference numerals are used, and reference is made thereto.

[0107] In Figure 11 and Figure 12In the medicament administration device 1a shown, the first breakable linear portion 35 of the breakable connection portion (breakable portion) 33a of the holding member 30a is formed above the second breakable linear portion 36 and above the upper end of the window portion 57 formed in the autoinjector main body 50. Further, in the breakable connection portion (breakable portion) 33a, breakage guiding portions 38, 38 are respectively formed from the breakage start portion 37 toward the first breakable linear portion 35 and the second breakable linear portion 36. The breakage guiding portion 38 is preferably formed by intermittent and linearly extending cuts or thin wall portions and does not penetrate the holding member 30a.

[0108] By breaking the breakable connection portion (breakable portion) 33a of the medicament administration device 1a and removing it from the medicament administration device 1a, as Figure 12 shown, the window portion 57 of the autoinjector 5 is exposed. (In addition, in Figure 12 , for the sake of illustration, the portion where the holding member (film-like packaging) exists is cross-hatched.) Thus, even when the light transmittance of the holding member (film-like packaging) 30a is low, or when printing is performed on the portion of the holding member (film-like packaging) 30a corresponding to the window portion 57, when using the medicament administration device 1a (after removing the breakable connection portion 33a), the inside of the prefilled syringe 52 can be visually confirmed through the window portion 57. Further, according to such a manner, when the medicament filled in the prefilled syringe 52 is light-intolerant, the holding member (film-like packaging) 30a can be a member with low light transmittance (having light-shielding properties).

[0109] In Figure 13 the medicament administration device 1b shown, the second breakable linear portion 36 of the breakable connection portion (breakable portion) 33b of the holding member 30b is formed below the first breakable linear portion 35 and below the upper end of the cap 56. Thus, in a state where the cap covering portion 32b does not have the reduced diameter portion (34) as described above and the separated housing holding portion 31b bundles and holds a plurality of autoinjector main bodies 50, it is easy to separate only the separated cap covering portion 32b from the medicament administration device 1b.

[0110] Figure 14 The medicament administration device 1c shown in Figure 14 has a gripping flap 39 with one end fixed to the breakable portion (breakable connection portion) 33 and the other end being a free end, and one end of the gripping flap 39 is fixed to a position close to the breakage start portion 37 ( Figure 14 the cross-hatched portion). Thus, when breaking the breakable portion (breakable connection portion) 33, the gripping flap 39 can be gripped and pulled, and breakage from the breakage start portion 37 can be easily performed.

[0111] In Figure 15In the medicament administration device 1d shown, the breakable connection part 33d of the holding part 30d is constituted by a breakable (peelable) belt part 33d (hatched in Figure 15 ). Specifically, the housing holding part 31d and the cap covering part 32d are constituted by separate film-like packages, and the lower end of the housing holding part 31d and the upper end of the cap covering part 32d are separated axially. The belt part 33d connects the housing holding part 31d and the cap covering part 32d by covering (peelably pasting) the lower end part of the housing holding part 31d with the upper end (upper edge) part and covering (peelably pasting) the upper end part of the cap covering part 32d with the lower end (lower edge) part. When using the medicament administration device 1d, the housing holding part 31d and the cap covering part 32d can be separated by peeling (breaking) the belt part 33d.

[0112] In Figure 16 the medicament administration device 1e shown, the breakable connection part 33e of the holding part 30e is constituted by the same film-like package as the cap covering part 32e and overlaps with the lower end part of the housing holding part 31e at the upper end part. The breakable connection part (breakable part) 33e has a breakable linear part 42 formed below the lower end of the housing holding part 31e. By breaking the breakable connection part (breakable part) 33e, the housing holding part 31e and the cap covering part 32e can be separated. Further, contrary to this embodiment, the breakable connection part of the holding part may also be constituted by the same film-like package as the housing holding part and overlap with the upper end part of the cap covering part at the lower end part.

[0113] In Figures 17 to 19 the medicament administration device 1f shown, the holding part 30f is made of a hard or semi-hard resin. Specifically, the housing holding part 31f is made of a hard or semi-hard resin and has a housing accommodating part 43 that accommodates (holds) a part of the housing 51 of the autoinjector 5 in a manner of locally covering from the outside. As Figure 18 shown, the housing accommodating part 43 extends a predetermined length in a substantially "C" - shaped cross-section along the axial direction ( Figure 17 the vertical direction in

[0114] ). Preferably, the housing accommodating part 43 firmly holds the housing 51 of the autoinjector 5 by the elastic force in a state where the outer wall part is elastically deformed. Figure 17 and Figure 18As shown, the housing holding part 31f includes a partition part 44 that holds the auto-injector main bodies 50, 50 of the auto-injectors 5, 5 housed (held) in two adjacent housing parts 43, 43 in a separated state from each other. The partition part 44 extends and protrudes downward in the axial direction of the housing part 43. In other words, the housing holding part 31f of the present embodiment has both the function of a housing holding part (housing part) for holding the housings of multiple auto-injectors and the function of an isolation member (partition part) for maintaining the auto-injector main bodies of two adjacent auto-injectors in a separated state from each other.

[0115] The cap covering part 32f of the holding part 30f is made of a hard or semi-hard resin and has a cap housing part 45 that houses (covers) a part of the cap 56 of the auto-injector 5 in a manner of partially covering from the outside. As Figure 19 shown, the cap housing part 45 houses the caps 56, 56 of two adjacent auto-injectors 5, 5 in a state of abutting against each other inside the cap housing part 45. Preferably, the cap housing part 45 firmly holds the caps 56, 56 of the auto-injectors 5, 5 by elastic force in a state where the outer wall part is elastically deformed.

[0116] The breakable connection part 33f of the holding part 30f is a substantially thin rod-shaped part that connects the housing holding part 31f and the cap covering part 32f. When using the medicament administration device 1f, the breakable connection part 33f can be broken (cut) so that the separated cap covering part 32f and multiple caps 56 are detached from the medicament administration device 1f at the same time, or only the separated cap covering part 32f is detached from the medicament administration device 1f. In addition, by breaking the breakable connection part 33f while holding the cap covering part 32f (and the cap 56), the breaking operation of the breakable connection part 33f and the detachment operation of the cap covering part 32f (and the cap 56) can be performed simultaneously.

[0117] In Figure 20 the medicament administration device 1g shown, the housing holding part of the holding part 30g is the above-mentioned resin-made housing holding part 31f, while the cap covering part 32g and the breakable connection part 33g are formed by a thin film member (thin film-like packaging member, shaded in Figure 20 ). The breakable connection part 33g overlaps with the lower end part of the housing holding part 31f (partition part 44) at the upper end part. The breakable connection part (breakable part) 33g has a breakable linear part 46 formed below the lower end of the housing holding part 31f. By breaking the breakable connection part (breakable part) 33g, the housing holding part 31f and the cap covering part 32g can be separated. In addition, contrary to the present embodiment, it may also be that the cap covering part of the holding part is made of resin and the housing holding part and the breakable connection part are thin film members.

[0118] Figure 21The shown medicament administration device 1h does not have an isolation member (40). In addition, the outer shape (outer diameter) of the cap 56 is smaller than the outer shape of the front end portion of the autoinjector main body 50. Even when the autoinjector main bodies 50, 50 of adjacent autoinjectors 5, 5 are in a juxtaposed state (axis-parallel state), the caps 56, 56 do not abut. Further, in the holding member 30h, a reduced-diameter portion (34) as described above is not formed in the cap covering portion 32h. Thus, by breaking the frangible connecting portion 33h, the separated housing holding portion 31h maintains the state of bundling and holding a plurality of autoinjector main bodies 50, and it is easy to detach only the separated cap covering portion 32h from the medicament administration device 1h.

[0119] In addition, as the width of the frangible portion which is a strip-shaped frangible portion of the holding member formed of a thin film member, it is preferably 1 to 20 mm, more preferably 2 to 15 mm, and particularly preferably 3 to 10 mm. Further, as the frangible portion (frangible connecting portion), it may be a substantially linear portion having a width but a narrow width (specifically, 2 mm or less).

[0120] The medicament administration device of the present invention includes a holding member that bundles and holds a plurality of autoinjectors. The holding member includes: a housing holding portion that holds the housings of a plurality of autoinjectors; a cap covering portion that covers the caps of a plurality of autoinjectors; and a frangible connecting portion that separably connects the housing holding portion and the cap covering portion. By breaking the frangible connecting portion, the housing holding portion and the cap covering portion are separated, and the separated housing holding portion maintains the state of bundling and holding a plurality of autoinjector main bodies. In addition, the separated cap covering portion can be detached from the medicament administration device simultaneously with a plurality of caps, or only the separated cap covering portion can be detached from the medicament administration device.

[0121] Thus, in the state before use (the state in which the housing holding portion and the cap covering portion are connected by the frangible connecting portion), it is difficult for the cap to fall off from the autoinjector, and safety can be improved. In addition, during use, by breaking the frangible connecting portion, the state of bundling and holding a plurality of autoinjector main bodies can be maintained, and a plurality of caps and / or the separated cap covering portion can be detached from the medicament administration device. Thus, the labor of preparing for administration can be reduced.

Claims

1. A medicament administration device includes a plurality of autoinjectors and a holding member that bundles and holds the plurality of autoinjectors. The autoinjector includes: an autoinjector main body that houses a prefilled syringe and a seal pressing mechanism in a cylindrical housing; and a cap that is removably attached to a front end portion of the autoinjector main body. It is characterized in that the holding member includes: a housing holding portion that holds the housings of the plurality of autoinjectors; a cap covering portion that covers the caps of the plurality of autoinjectors; and a breakable connecting portion that separably connects the housing holding portion and the cap covering portion, by breaking the breakable connecting portion, the housing holding portion and the cap covering portion are separated, and the separated housing holding portion maintains the state of bundling and holding the plurality of autoinjector main bodies. In addition, the separated cap covering portion can be detached from the medicament administration device simultaneously with the plurality of caps, or only the separated cap covering portion can be detached from the medicament administration device.

2. The medicament administration device according to claim 1, characterized in that the separated cap covering portion can be detached from the medicament administration device simultaneously with the plurality of caps.

3. The medicament administration device according to claim 1, characterized in that the holding member is a film member.

4. The medicament administration device according to claim 3, characterized in that the film member is a heat-shrinkable film member.

5. The medicament administration device according to claim 1, characterized in that the holding member is a single film-like packaging member, and the breakable connecting portion is a linear or strip-shaped breakable portion provided on the holding member.

6. The medicament administration device according to claim 5, characterized in that the breakable portion is formed by intermittent and linearly extending slits or thin-walled portions and does not penetrate the holding member.

7. The medicament administration device according to claim 5, characterized in that the breakable connecting portion is a strip-shaped breakable portion provided on the holding member, and the breakable portion has a fracture start portion extending in the width direction of the breakable portion.

8. The medicament administration device according to claim 7, characterized in that the fracture start portion is formed by intermittent and linearly extending slits or thin-walled portions in the width direction of the breakable portion.

9. The medicament administration device according to claim 7, characterized in that it includes a gripping tab, one end of which is fixed to the breakable portion and the other end is a free end, and the one end of the gripping tab is fixed at a position close to the fracture start portion.

10. The medicament administration device according to claim 1, characterized in that it includes a spacer member that is disposed between the housings of two adjacent autoinjectors and is used to maintain the autoinjector main bodies of the two adjacent autoinjectors in a mutually separated state.

11. The medicament administration device according to claim 10, characterized in that the housing holding portion is a film-like packaging member, The housing holding part covers the outer periphery of the housings of the two adjacent autoinjectors provided with the isolation member, maintaining the autoinjector bodies of the two adjacent autoinjectors in a separated and juxtaposed state.

12. The medicament administration device according to claim 1, wherein The cap covering part is a film-like packaging member that covers the outer periphery of the caps of the two adjacent autoinjectors, and within the cap covering part, the caps of the two adjacent autoinjectors abut against each other.

Images