Reflux protection monitoring system based on pH response type gel patch

Abstract

The invention discloses a reflux protection monitoring system based on a pH response type gel patch, and belongs to the technical field of medical instruments. According to the system, real-time monitoring and physical protection of the gastroesophageal reflux disease are achieved through a pH response type gel patch arranged on the outer wall of an endoscope, and the patch is composed of a pH response type gel layer containing a polyacrylic acid-chitosan cross-linked structure, an outer attachment layer and a double-sided adhesion layer; the gel expands in an acidic environment to form a temporary physical barrier and release the loaded fluorescein dye. The system comprises a controller with a display, and a laryngoscope and endoscope assembly connected with an adjustable supporting arm, the supporting arm adopts a combined structure of a rotating arm and a telescopic arm, synchronous locking of angle and length is realized through a propping rod driven by a conical block, and the laryngoscope is fixed with the end part of the telescopic arm through a clamping assembly. The technical defects that a traditional monitoring means is high in invasiveness and cannot achieve continuous protection are overcome, and the double functions of backflow monitoring and physical blocking are achieved through the non-invasive patch.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a reflux prevention monitoring system based on a pH-responsive gel patch. Background Art

[0002] In the medical field, gastroesophageal reflux disease, as a common digestive system disease, its accurate diagnosis and effective monitoring are crucial for the treatment and management of patients. Existing reflux monitoring technologies (such as 24-hour esophageal pH monitoring) require the insertion of a catheter, which is highly invasive and uncomfortable; while imaging examinations (such as barium meal imaging) cannot track in real time dynamically. In addition, traditional anti-reflux drugs (such as proton pump inhibitors) cannot provide a physical barrier effect. Summary of the Invention

[0003] The purpose of the present invention is to solve the disadvantages in the prior art that it is highly invasive and uncomfortable; while imaging examinations (such as barium meal imaging) cannot track in real time dynamically. In addition, traditional anti-reflux drugs (such as proton pump inhibitors) cannot provide a physical barrier effect, and a reflux prevention monitoring system based on a pH-responsive gel patch is proposed.

[0004] In order to achieve the above purpose, the present invention adopts the following technical scheme:

[0005] A reflux prevention monitoring system based on a pH-responsive gel patch, which is used for detecting esophageal reflux in patients with gastroesophageal reflux disease, includes a controller arranged on one side of the bed body. A display is provided on the controller, and an endoscope is connected to one side of the controller;

[0006] A laryngoscope for guiding the endoscope is provided on one side of the controller. A support arm is connected between the laryngoscope and the controller. The support arm is used to support the laryngoscope, liberating the hands of medical staff. The support arm is composed of a rotating arm and a telescopic arm. A fixing member is arranged inside the rotating arm, and the fixing member is used to fix both the rotation angle of the rotating arm and the telescopic length of the telescopic arm at the same time;

[0007] It also includes a connecting member arranged at one end of the telescopic arm. The connecting member is clamped with the laryngoscope, and the laryngoscope is fixed on the telescopic arm by using the connecting member;

[0008] A patch is arranged on the outer wall of the endoscope, and the patch expands to form a physical barrier and releases a fluorescence signal in an acidic environment by using its characteristics.

[0009] In a possible design, the fixing part includes a first interference rod slidably arranged in a rotating arm, one end of the rotating arm is L-shaped, and a fixed shaft is rotatably arranged inside the rotating arm through a bearing. The fixed shaft is fixed to one side of the controller by welding, and one end of the first interference rod is in conflict with the fixed shaft. A bolt is threaded on the outer wall of the rotating arm, and a conical block is threaded on the bottom end of the bolt and is located in the rotating arm. The conical surface is used to drive the first interference rod to move and conflict with the fixed shaft.

[0010] In a possible design, the telescopic arm includes a sleeve rod welded to the other end of the rotating arm, a sliding rod is passed through the sleeve rod, and a second interference rod that interferes with the sliding rod is slidably provided inside the rotating arm, and the conical surface of the conical block is used to drive the second interference rod to interfere with the sliding rod.

[0011] In a possible design, the connecting member includes a fixing ring welded to one end of a sliding rod, a connecting seat is clamped on one side of the fixing ring, the laryngoscope is fixed to one side of the connecting seat, a screw is provided on the inner thread of the sleeve rod, one end of the screw is in contact with the connecting seat, and the connecting seat is fixed to one end of the sleeve rod by pulling the fixing ring and the screw in reverse.

[0012] In a possible design, two mounting frames are welded to the outer wall of the fixing ring, two guide rods are fixedly provided in the mounting frames, two sliding blocks are slidably sleeved on the two guide rods, and a tension spring is sleeved on the outer wall of the guide rod and located between the two sliding blocks, and both ends of the tension spring are respectively fixedly connected to the mutually close sides of the two sliding blocks, a clamping block is fixedly provided on one side of the sliding block, and a plurality of connecting strips used in conjunction with the clamping blocks are fixedly provided on one side of the connecting seat, and clamping grooves used in conjunction with the clamping blocks are provided on both sides of the connecting strips.

[0013] In a possible design, two groups of pressure rollers are rotatably provided on one side of the connecting seat through bearings, and a conveying channel is formed between the two groups of pressure rollers, which corresponds to the top end of the guide groove, and a hand wheel is provided on one of the pressure rollers.

[0014] In one possible design, the patch includes a pH-responsive gel, one side of the pH-responsive gel is provided with an external layer, and a storage cavity is formed between the external layer and the pH-responsive gel for storing a pH-sensitive fluorescent dye.

[0015] In a possible design, the outer sides of the pH-responsive gel and the outer layer are both provided with an adhesive layer, and the adhesive layer is used to fix them to the esophagus and the endoscope.

[0016] In the present invention, in the reflux prevention monitoring system based on a pH-responsive gel patch, the pH-responsive gel patch on the outer wall of the endoscope swells in an acidic environment to form a physical barrier and simultaneously releases a fluorescence signal, enabling real-time monitoring of gastroesophageal reflux. The display shows the detection data and images, allowing medical staff to intuitively and quickly obtain the reflux information in the patient's esophagus, improving the accuracy and efficiency of detection.

[0017] In the present invention, in the reflux prevention monitoring system based on a pH-responsive gel patch, the laryngoscope is connected to the controller through a support arm. The support arm consists of a rotating arm and a telescopic arm. Fixing parts can be used to fix both the rotation angle of the rotating arm and the telescopic length of the telescopic arm simultaneously, enabling the position of the laryngoscope to be flexibly adjusted and stabilized, which helps medical staff perform endoscope operations more precisely and improves the detection efficiency.

[0018] In the present invention, in the reflux prevention monitoring system based on a pH-responsive gel patch, the storage cavity formed between the pH-responsive gel and the outer attachment layer is used to store a pH-sensitive fluorescent dye, enabling the patch to accurately respond and release a fluorescence signal in an acidic environment, providing an intuitive basis for reflux detection.

[0019] In the present invention, the support arm liberates the hands of medical staff and realizes stable positioning of the laryngoscope. Combining with a precisely adjustable fixing and connection mechanism, it improves the operation convenience and detection stability. The patch swells in an acidic environment to form a physical barrier and releases a fluorescence signal, realizing real-time monitoring and precise feedback. At the same time, the adhesive layer design ensures reliable fixation, significantly improving the accuracy, efficiency, and patient comfort of gastroesophageal reflux disease detection, providing strong support for clinical diagnosis and treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is a three-dimensional structural schematic diagram of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention;

[0021] Figure 2 is a structural schematic diagram of the support wall of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention;

[0022] Figure 3 is a cross-sectional structural schematic diagram of the support arm of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention;

[0023] Figure 4 is a structural schematic diagram of the chuck and mounting plate of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention;

[0024] Figure 5Schematic diagram of the block and sliding rod structure of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention;

[0025] Figure 6 Schematic diagram of the patch structure of a reflux prevention monitoring system based on a pH-responsive gel patch proposed by the present invention.

[0026] In the figure: 1, bed body; 2, controller; 3, display; 4, support arm; 5, endoscope; 6, laryngoscope; 7, connecting seat; 8, rotating arm; 9, telescopic arm; 10, bolt; 11, guide groove; 12, pressure roller; 13, handwheel; 14, fixed shaft; 15, first abutting rod; 16, second abutting rod; 17, tapered block; 18, sleeve rod; 19, sliding rod; 20, fixed ring; 21, mounting frame; 22, block; 23, connecting strip; 24, card slot; 25, guide rod; 26, tension spring; 27, sliding block; 28, patch; 29, adhesion layer; 30, pH-responsive gel; 31, outer attachment layer; 32, screw rod. Specific embodiments

[0027] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0028] Embodiment 1

[0029] Existing reflux monitoring technologies (such as 24-hour esophageal pH monitoring) require the insertion of a catheter, which is highly invasive and uncomfortable; while imaging examinations (such as barium meal imaging) cannot track in real time and dynamically. In addition, traditional anti-reflux drugs (such as proton pump inhibitors) cannot provide a physical barrier effect. For this reason, a monitoring system is designed in this solution.

[0030] Refer to Figures 1 - 6 , a monitoring system, including: a controller 2 provided on one side of the bed body 1, and a display 3 is equipped on the controller 2 for real-time display of detection data and images. An endoscope 5 is connected to one side of the controller 2 for directly observing the esophagus of the patient. To assist the operation of the endoscope 5, a laryngoscope 6 is also provided on one side of the controller 2. The laryngoscope 6 is connected to the controller 2 through a support arm 4. The design of the support arm 4 aims to liberate the hands of medical staff and improve the operation stability and accuracy.

[0031] The support arm 4 is composed of a rotating arm 8 and a telescopic arm 9. A fixing member is provided inside the rotating arm 8 for simultaneously fixing the rotation angle of the rotating arm 8 and the telescopic length of the telescopic arm 9 to ensure the stable position of the laryngoscope 6 during the detection process.

[0032] The fixing member includes a first abutting rod 15 slidably arranged in the rotating arm 8. One end of the rotating arm 8 is L-shaped, and a fixed shaft 14 is rotatably arranged inside through a bearing. The fixed shaft 14 is fixed to one side of the controller 2 by welding, and one end of the first abutting rod 15 abuts against the fixed shaft 14. A bolt 10 is provided on the outer wall of the rotating arm 8 in a threaded manner, and a tapered block 17 located inside the rotating arm 8 is provided at the bottom end of the bolt 10 in a threaded manner. By rotating the bolt 10, the tapered block 17 moves downward, and the first abutting rod 15 is driven to move by using the tapered surface, and then abuts against the fixed shaft 14 to fix the angle of the rotating arm 8. To increase the friction between the first abutting rod 15 and the fixed shaft 14, anti-slip grooves are provided on one end of the first abutting rod 15 and the outer wall of the fixed shaft 14.

[0033] The telescopic arm 9 includes a sleeve rod 18 welded to the other end of the rotating arm 8, and a sliding rod 19 is arranged through the sleeve rod 18. A second abutting rod 16 that abuts against the sliding rod 19 is slidably arranged inside the rotating arm 8. Similarly, the tapered surface of the tapered block 17 is used to drive the second abutting rod 16 to abut against the sliding rod 19 to fix the length of the telescopic arm 9. To increase the friction between the second abutting rod 16 and the sliding rod 19, anti-slip grooves are provided on one end of the second abutting rod 16 and the outer wall of the sliding rod 19.

[0034] The position of the laryngoscope 6 can be adjusted flexibly, and at the same time, the stability after adjustment is ensured, which helps medical staff perform endoscopic operations more accurately and improves the detection efficiency and accuracy.

[0035] The connecting member is arranged at one end of the telescopic arm 9 and is clamped with the laryngoscope 6 to ensure that the laryngoscope 6 is firmly fixed on the telescopic arm 9.

[0036] The connecting member includes a fixing ring 20 welded and sleeved at one end of the sliding rod 19. A connecting seat 7 is clamped on one side of the fixing ring 20, and the laryngoscope 6 is fixed on one side of the connecting seat 7. A screw rod 32 is provided in the sleeve rod 18 in a threaded manner, and one end of the screw rod 32 abuts against the connecting seat 7. By the reverse pulling of the fixing ring 20 and the screw rod 32, the connecting seat 7 is fixed at one end of the sleeve rod 18.

[0037] A patch 28 is provided on the outer wall of the endoscope 5. The patch 28 forms a physical barrier and releases a fluorescent signal by using its expansion characteristic in an acidic environment, providing an intuitive basis for reflux detection. And the patch 28 gradually degrades within 24 - 48 hours, avoiding the need for a second operation to remove it.

[0038] The patch 28 includes a pH-responsive gel 30. On one side of the pH-responsive gel 30, there is an outer attachment layer 31. A storage cavity is formed between the outer attachment layer 31 and the pH-responsive gel 30 for storing a pH-sensitive fluorescent dye. The pH-sensitive fluorescent dye used for loading is fluorescein. To ensure that the loaded pH-sensitive fluorescent dye can be discharged under an external force, a plurality of pinholes are formed on the outer side of the outer attachment layer 31, and the pinholes can ensure that the loaded pH-sensitive fluorescent dye will not be discharged without an external force. The pH-responsive gel 30 is formed by crosslinking polyacrylic acid (PAA) and chitosan (CS), and has pH sensitivity (swelling in an acidic environment and shrinking in a neutral environment). When gastric acid refluxes to the esophagus, the pH-responsive gel 30 swells to form a temporary physical barrier to prevent further upward surge of gastric acid.

[0039] Adhesive layers 29 are provided on the outer sides of both the pH-responsive gel 30 and the outer attachment layer 31. The patch 28 is fixed to the esophagus and the endoscope 5 by using the adhesive layers 29. The adhesive layers 29 contain sodium alginate to ensure that the patch is firmly attached to the esophageal mucosa.

[0040] The patch 28 utilizes the characteristics of the pH-responsive gel to swell in an acidic environment to form a physical barrier, effectively preventing the reflux material from further eroding the esophagus, and simultaneously releasing a fluorescent signal to provide an intuitive detection basis for medical staff. In addition, the design of the adhesive layer 29 ensures the stable attachment of the patch 28, improves the accuracy and reliability of the detection. At the same time, the size of the patch 28 and the gel swelling rate can be customized according to the esophageal anatomical structure of the patient, enhancing the adaptability and protection effect.

[0041] This application can be used in the field of medical devices and other fields suitable for this application.

[0042] Embodiment 2

[0043] Reference Figures 1 - 6 , on the basis of Embodiment 1, an improvement is made: A reflux protection monitoring system based on a pH-responsive gel patch is applied to the field of medical devices. Two mounting frames 21 are welded to the outer wall of the fixing ring 20. Two guide rods 25 are fixedly arranged in the mounting frames 21. Two sliding blocks 27 are slidably sleeved on the two guide rods 25. A tension spring 26 is sleeved on the outer wall of the guide rod 25 and is located between the two sliding blocks 27. The two ends of the tension spring 26 are respectively fixedly connected to the sides of the two sliding blocks 27 close to each other for driving the two sliding blocks 27 to approach each other. A clamping block 22 is fixedly arranged on one side of the sliding block 27. A plurality of connecting strips 23 that cooperate with the clamping block 22 are fixedly arranged on one side of the connecting seat 7. Slots 24 that cooperate with the clamping block 22 are formed on both sides of the connecting strip 23. Through the pulling force of the tension spring 26, the clamping block 22 is clamped into the slot 24 to achieve a firm clamping connection between the fixing ring 20 and the connecting seat 7.

[0044] And on one side of the connecting seat 7, two pressing rollers 12 are rotatably arranged through bearings. A conveying channel is formed between the two pressing rollers 12, corresponding to the top end of the guiding groove 11. A handwheel 13 is arranged on one of the pressing rollers 12, and the size of the conveying channel is adapted to the endoscope 5. When the endoscope 5 is located in the conveying channel, only by rotating the handwheel 13 to drive the pressing roller 12 to rotate, the friction force between the pressing roller 12 and the endoscope 5 can be used to drive the endoscope 5 to move, imitating the manual insertion action to ensure the stability during the insertion process.

[0045] During use, insert the laryngoscope 6 into the patient's oral cavity and hold it with one hand. Then, use the other hand to turn the support arm 4 on the controller 2 so that the mounting frame 21 is located on one side of the connecting seat 7. Then, pull the mounting frame 21 closer to the connecting bar 23. When the clamping block 22 contacts the connecting bar 23, the inclined surface can be used to drive the clamping block 22 to move outwards until the clamping block 22 moves into the clamping groove 24. At this time, the two clamping blocks 22 can approach each other under the action of the tension spring 26 to clamp the connecting bar 23. Then, rotate the bolt 10. During the rotation of the bolt 10, the threaded portion can be used to drive the conical block 17 to move downwards. During the movement, the conical surface is used to drive the first contact rod 15 and the second contact rod 16 to move away from each other, so that the first contact rod 15 contacts the fixed shaft 14 and the second contact rod 16 contacts the sleeve rod 18, enabling the simultaneous fixation of the rotating arm 8 and the sleeve rod 18.

[0046] Then, rotate the screw rod 32 so that the screw rod 32 moves within the sleeve rod 18. During the movement, it can cooperate with the sleeve rod 18 to contact the connecting bar 23 and further fix the connecting bar 23 in cooperation with the mounting frame 21. At this time, the hand can be released from the laryngoscope 6.

[0047] Then, install the patch 28 on the endoscope 5 so that one side of the outer attachment layer 31 adheres to the endoscope 5. Then, use the endoscope 5 to send the patch 28 to the vicinity of the cardia at the lower end of the esophagus. At this time, the adhesion layer 29 quickly combines with the mucosa to fix the patch 28, and then the endoscope 5 is taken out.

[0048] When gastric acid refluxes to the esophagus: the pH-responsive gel 30 swells to form a temporary physical barrier to prevent further upward flow of gastric acid and squeeze the outer attachment layer 31, causing the fluorescent dye in the outer attachment layer 31 to be released. When detection is required, insert the endoscope 5 into the esophagus again, and capture the fluorescent signal in the esophagus through the endoscope 5 to locate the position where reflux occurs.

[0049] The patch 28 gradually degrades within 24 - 48 hours after being worn and is excreted from the body along with feces.

[0050] However, as is well known to those skilled in the art, the working principles and wiring methods of the display 3, the endoscope 5, and the laryngoscope 6 are common knowledge, and they all belong to conventional means or well-known common sense. Therefore, they will not be elaborated here. Those skilled in the art can make any selection according to their needs or convenience.

[0051] The above are only the preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A reflux protection monitoring system based on a pH-responsive gel patch, which is used for esophageal reflux detection in patients with gastroesophageal reflux disease, characterized in that: It comprises a controller (2) arranged on one side of a bed (1), the controller (2) being provided with a display (3), and one side of the controller (2) being connected to an endoscope (5); A laryngoscope (6) for guiding the endoscope (5) is provided on one side of the controller (2); a support arm (4) is connected between the laryngoscope (6) and the controller (2); the support arm (4) is used to support the laryngoscope (6) to free the hands of medical personnel; the support arm (4) is composed of a rotating arm (8) and a telescopic arm (9); a fixing part is provided inside the rotating arm (8); and the fixing part is used to simultaneously fix the rotating angle of the rotating arm (8) and the telescopic length of the telescopic arm (9); It also includes a connecting piece arranged at one end of the telescopic arm (9), the connecting piece being snap-connected with the laryngoscope (6), and the laryngoscope (6) being fixed to the telescopic arm (9) by means of the connecting piece; The outer wall of the endoscope (5) is provided with a patch (28), which utilizes the characteristics of the patch (28) to swell in an acidic environment to form a physical barrier and release a fluorescent signal.

2. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 1, characterized in that: The fixing member comprises a first abutment rod (15) slidably arranged in a rotating arm (8); one end of the rotating arm (8) is L-shaped, and a fixed shaft (14) is rotatably arranged in the interior thereof via a bearing; the fixed shaft (14) is fixed to one side of the controller (2) by welding; one end of the first abutment rod (15) abuts against the fixed shaft (14); a bolt (10) is threadedly arranged on the outer wall of the rotating arm (8); a conical block (17) located in the rotating arm (8) is threadedly arranged at the bottom end of the bolt (10); and the first abutment rod (15) is driven by the conical surface to move and abut against the fixed shaft (14).

3. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 2, characterized in that: The telescopic arm (9) comprises a sleeve rod (18) welded to the other end of the rotating arm (8), a sliding rod (19) is provided inside the sleeve rod (18), a second abutting rod (16) is slidably provided inside the rotating arm (8) and abuts against the sliding rod (19), and the conical surface of the conical block (17) is used to drive the second abutting rod (16) to abut against the sliding rod (19).

4. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 3, characterized in that: The connecting member comprises a fixing ring (20) welded and sleeved on one end of a sliding rod (19); a connecting seat (7) is clamped on one side of the fixing ring (20); the laryngoscope (6) is fixed on one side of the connecting seat (7); the sleeve rod (18) is internally threaded with a screw rod (32); one end of the screw rod (32) is in contact with the connecting seat (7); the connecting seat (7) is fixed to one end of the sleeve rod (18) by pulling the fixing ring (20) and the screw rod (32) in opposite directions.

5. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 4, characterized in that: Two installation frames (21) are welded to the outer wall of the fixing ring (20), two guide rods (25) are fixedly arranged in the installation frame (21), two sliding blocks (27) are slidably sleeved on the two guide rods (25), a tension spring (26) located between the two sliding blocks (27) is sleeved on the outer wall of the guide rod (25), two ends of the tension spring (26) are respectively fixedly connected to the mutually close sides of the two sliding blocks (27), a clamping block (22) is fixedly arranged on one side of the sliding block (27), a plurality of connecting strips (23) used in conjunction with the clamping blocks (22) are fixedly arranged on one side of the connecting seat (7), and clamping grooves (24) used in conjunction with the clamping blocks (22) are provided on both sides of the connecting strips (23).

6. A pH-responsive gel patch-based reflux protection monitoring system according to claim 4, characterized in that: Two groups of pressure rollers (12) are rotatably provided on one side of the connecting seat (7) via bearings, and a conveying channel is formed between the two groups of pressure rollers (12) and corresponds to the top end of the guide groove (11), and a hand wheel (13) is provided on one of the pressure rollers (12).

7. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 1, characterized in that: The patch (28) comprises a pH-responsive gel (30), one side of the pH-responsive gel (30) is provided with an external layer (31), and a storage cavity is formed between the external layer (31) and the pH-responsive gel (30) for storing a pH-sensitive fluorescent dye.

8. A reflux protection monitoring system based on a pH-responsive gel patch according to claim 7, characterized in that: The pH responsive gel (30) and the outer layer (31) are both provided with an adhesive layer (29) on their outer sides, and the adhesive layer (29) is used to fix them on the esophagus and the endoscope (5).

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