Veterinary drug formula of traditional Chinese medicine components for preventing parasitic diseases of livestock and poultry and application of veterinary drug formula

Abstract

The veterinary drug formula comprises the following raw materials: the traditional Chinese medicine components: 10 to 20 g of pumpkin vine, 10 to 15 g of radix stemonae, 15 to 25 g of betel nut root, 10 to 20 g of immature bitter orange, 10 to 15 g of common carpesium fruit, 10 to 20 g of radix scutellariae, 8 to 12 g of fructus cnidii, 8 to 12 g of rhizoma bletillae, 8 to 12 g of sanguisorba officinalis, 6 to 10 g of endothelium corneum gigeriae galli, 8 to 12 g of radix sophorae flavescentis, 8 to 12 g of hairyvein agrimony, 6 to 10 g of perilla leaf, 5 to 15 g of astragalus polysaccharide, 6 to 12 g of codonopsis pilosula and 6 to 10 g of liquorice; through the synergistic effect of multiple components, the parasite expelling efficiency, repairing and safety are considered, and the parasite expelling composition is suitable for complex parasite infection and livestock and poultry groups needing rapid rehabilitation.

Description

Technical Field

[0001] The present invention relates to the field of prevention of livestock and poultry parasitic diseases, specifically to a veterinary drug formula and its application of traditional Chinese medicine components in the prevention of livestock and poultry parasitic diseases. Background Art

[0002] There are a wide variety of pathogens of parasitic diseases in domestic livestock and poultry, which are widely distributed and often harm the health of animals in a hidden way, causing various chronic and wasting diseases in livestock and poultry. It not only affects the growth and development of livestock and poultry, reduces the quality and quantity of livestock and poultry products, but also causes a large number of deaths of livestock and poultry, bringing serious economic losses to the breeding industry, having a great negative impact on the development of animal husbandry, and some types also pose a threat to people's health. Therefore, high attention must be paid and practical and effective prevention and control measures must be taken.

[0003] According to the disclosed patent 201610919309.X, a traditional Chinese medicine decoction for preventing and treating livestock and poultry parasitic diseases and its preparation method, the components and their weight ratio of the traditional Chinese medicine decoction are as follows: Melia azedarach bark 5 - 10 parts; Artemisia annua 10 - 15 parts; Areca catechu 5 - 10 parts; Garlic 10 - 15 parts; Stemona sessilifolia 10 - 15 parts; Portulaca oleracea 5 - 10 parts; Tangerine peel 10 - 15 parts; Dryopteris crassirhizoma 5 - 10 parts; Pumpkin seeds 10 - 15 parts; Sophora flavescens 10 - 15 parts; Rheum officinale 5 - 10 parts; Licorice 10 - 15 parts. The present invention kills and expels parasites by its multi-targets, containing a variety of active ingredients and acting on a variety of effective ways to destroy the various living environments of parasites, and is formulated with laxatives to promote the excretion of worms. It has no drug residues, no toxic and side effects, is not easy to produce drug resistance, has good safety, is convenient to use, is easy to absorb, meets the requirements of safe veterinary drugs and guarantees the safety of animal-derived food, and is an ideal traditional Chinese medicine decoction for preventing and treating livestock and poultry parasitic diseases.

[0004] However, in the process of use, the traditional veterinary drug formula of traditional Chinese medicine components in the prevention of livestock and poultry parasitic diseases has limitations in expelling worms, mainly targeting common parasites such as roundworms and hookworms, and has relatively weak targeting for tapeworms, trematodes and refractory parasites (such as Giardia). On the other hand, it lacks repair and conditioning after expelling worms, neither has immune-enhancing components to promote the recovery of the body, nor has hemostatic and astringent or stomach-strengthening and digestion-promoting drugs to deal with potential injuries after expelling worms. At the same time, anti-inflammatory, nutritional supplement and antibacterial drugs are not added, which is likely to exacerbate gastrointestinal irritation, increase the risk of infection and delay the recovery process. Therefore, new technical solutions need to be designed to solve this problem. Summary of the Invention

[0005] The object of the present invention is to overcome the deficiencies of the prior art, meet the actual needs, and provide a veterinary drug formula and its application of traditional Chinese medicine components in preventing parasitic diseases of livestock and poultry, so as to solve the technical problems of the current traditional veterinary drug formula of traditional Chinese medicine components in preventing parasitic diseases of livestock and poultry, where the deworming is limited to common parasites such as roundworms and hookworms, and the targeting of tapeworms, trematodes and refractory parasites (such as Giardia) is relatively weak. On the other hand, there is a lack of repair and conditioning after deworming, neither immune-enhancing components to promote the recovery of the body, nor hemostatic and astringent or stomach-strengthening and digestion-promoting drugs to deal with the potential damage after deworming. At the same time, anti-inflammatory, nutritional supplement and antibacterial drugs are not added, which is likely to exacerbate gastrointestinal irritation, increase the risk of infection and delay the recovery process.

[0006] To achieve the object of the present invention, the technical solution adopted by the present invention is: designing a veterinary drug formula of traditional Chinese medicine components in preventing parasitic diseases of livestock and poultry, including the following raw materials:

[0007] Traditional Chinese medicine components: 10 - 20 g of pumpkin vine, 10 - 15 g of stemona root, 15 - 25 g of areca root, 10 - 20 g of immature bitter orange, 10 - 15 g of carpesium fruit, 10 - 20 g of scutellaria root, 8 - 12 g of cnidium fruit, 8 - 12 g of bletilla striata, 8 - 12 g of sanguisorba officinalis, 6 - 10 g of chicken gizzard-membrane, 8 - 12 g of sophora flavescens, 8 - 12 g of agrimony, 6 - 10 g of perilla leaf, 5 - 15 g of astragalus polysaccharide, 6 - 12 g of codonopsis pilosula, 6 - 10 g of liquorice root;

[0008] Western medicine components: 0.50 - 1.50 mg of albendazole, 0.01 - 0.03 mg of ivermectin, 0.3 - 0.7 mg of sodium sulfachloropyrazine;

[0009] Auxiliary components: 5 - 15 g of vitamin C, 5 - 10 g of sodium bicarbonate, 10 - 20 g of glucose.

[0010] Preferably, the dosages of the traditional Chinese medicine components are 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of carpesium fruit, 15 g of scutellaria root, 10 g of cnidium fruit, 10 g of bletilla striata, 10 g of sanguisorba officinalis, 8 g of chicken gizzard-membrane, 10 g of sophora flavescens, 10 g of agrimony, 8 g of perilla leaf, 10 g of astragalus polysaccharide, 8 g of codonopsis pilosula, 8 g of liquorice root;

[0011] 20 g of pumpkin vine, 15 g of stemona root, 25 g of areca root, 20 g of immature bitter orange, 15 g of carpesium fruit, 20 g of scutellaria root, 12 g of cnidium fruit, 12 g of bletilla striata, 12 g of sanguisorba officinalis, 10 g of chicken gizzard-membrane, 12 g of sophora flavescens, 12 g of agrimony, 10 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of codonopsis pilosula, 10 g of liquorice root;

[0012] 10 g of pumpkin vine, 10 g of stemona root, 15 g of areca root, 10 g of immature bitter orange, 10 g of carpesium fruit, 10 g of skullcap root, 8 g of cnidium fruit, 8 g of bletilla tuber, 8 g of burnet root, 6 g of chicken gizzard-membrane, 8 g of lightyellow sophora root, 8 g of hairyvein agrimony herb, 6 g of perilla leaf, 5 g of astragalus polysaccharide, 6 g of codonopsis pilosula, 6 g of liquorice root;

[0013] 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of carpesium fruit, 15 g of skullcap root, 10 g of cnidium fruit, 10 g of bletilla tuber, 10 g of burnet root, 8 g of chicken gizzard-membrane, 10 g of lightyellow sophora root, 10 g of hairyvein agrimony herb, 8 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of codonopsis pilosula, 10 g of liquorice root.

[0014] Preferably, the dosage of the western medicine components is 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, and 0.5 mg / kg body weight of sodium sulfachloropyrazine;

[0015] 1.5 mg / kg body weight of albendazole, 0.03 mg / kg body weight of ivermectin, and 0.7 mg / kg body weight of sodium sulfachloropyrazine;

[0016] 0.5 mg / kg body weight of albendazole, 0.01 mg / kg body weight of ivermectin, and 0.3 mg / kg body weight of sodium sulfachloropyrazine;

[0017] 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, and 0.5 mg / kg body weight of sodium sulfachloropyrazine.

[0018] Preferably, the dosage of the auxiliary components is 10 g of vitamin C, 8 g of sodium bicarbonate, and 10 g of glucose;

[0019] 15 g of vitamin C, 10 g of sodium bicarbonate, and 20 g of glucose;

[0020] 5 g of vitamin C, 5 g of sodium bicarbonate, and 10 g of glucose;

[0021] 15 g of vitamin C, 8 g of sodium bicarbonate, and 20 g of glucose.

[0022] Preferably, the total mass ratio of the traditional Chinese medicine components in the formula is 60 - 75%, the total mass ratio of the western medicine components is 15 - 25%, and the total mass ratio of the auxiliary components is 10 - 20%.

[0023] Preferably, the preparation forms of the traditional Chinese medicine components, western medicine components, and auxiliary components are powder and granule.

[0024] The preparation method of the above veterinary drug formula includes the following steps:

[0025] S1. Weigh the traditional Chinese medicine components according to the ratio, crush and sieve them, and mix them evenly;

[0026] S2. Weigh the western medicine components according to the proportion and mix them with the traditional Chinese medicine powder in S1;

[0027] S3. Add vitamin C, sodium bicarbonate and glucose, stir evenly and make into the target dosage form.

[0028] Preferably, the sieve mesh number in S1 is 80 - 100 meshes, and the mixing time is 20 - 30 min.

[0029] The use of the above-mentioned veterinary drug formula for preventing livestock and poultry parasitic diseases.

[0030] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0031] 1. Through the synergistic effect of natural plant components and modern drugs, the present invention achieves an all-round coverage of multiple types of parasites. The areca root utilizes a stronger anthelmintic effect than traditional areca, synergizes with pumpkin vine and carpesium fruit, and directly kills intestinal parasites such as roundworms, hookworms and tapeworms; the combination of stemona root and sophora flavescens not only strengthens the killing effect on nematodes, but also treats skin parasites (such as sarcoptes scabiei); the addition of ivermectin and albendazole further covers nematodes, trematodes and arthropod parasites (such as mites and ticks), forming a broad-spectrum anthelmintic barrier. The present invention takes into account the safety of natural components (such as traditional herbs like pumpkin vine and stemona root) and the high efficiency of modern drugs (such as ivermectin and albendazole), reduces the risk of drug resistance, and provides a more comprehensive solution for mixed infections or complex parasitic cases, meeting the clinical needs of quickly controlling symptoms and reducing the recurrence rate.

[0032] 2. In the present invention, astragalus polysaccharide and codonopsis pilosula enhance the immune function, promote the repair of intestinal mucosa and reduce the inflammatory reaction after anthelmintic treatment; the hemostatic and astringent effects of bletilla striata and sanguisorba officinalis effectively relieve intestinal bleeding or ulcers; the stomach-strengthening and digestion-promoting effect of chicken gizzard-membrane improves the digestive function decline caused by parasites. The three work together to achieve a complete closed-loop of anthelmintic treatment, repair and conditioning, and accelerate recovery.

[0033] 3. In the present invention, the coordinating effect of licorice relieves the irritation of anthelmintics to the gastrointestinal tract; the supplementation of vitamin C and glucose provides essential nutrients for the body and enhances the resistance; the antibacterial prevention of sulfachloropyrazine sodium effectively reduces the risk of secondary infection, ensures the safety and effectiveness of the anthelmintic process, and reduces potential complications.

[0034] 4. In the present invention, since livestock and poultry are weak after deworming and are vulnerable to wind-cold invasion, the pungent-warm property of Perilla leaf can relieve exterior syndrome and dispel cold, reducing symptoms such as fever and cough caused by exogenous factors. After synergizing with Areca root and Carpesium fruit, as Areca root and Carpesium fruit are likely to cause slight abdominal pain during deworming, the qi-regulating effect of Perilla leaf can relieve intestinal spasm, alleviate pain, and promote appetite. After synergizing with Licorice root, Licorice root harmonizes the properties of the medicinal herbs, and Perilla leaf relieves exterior syndrome. The combination of the two can balance the potential impact of the anthelmintic on the body surface, reducing the risk of susceptibility to weakness in livestock and poultry after deworming.

[0035] In summary, through the synergistic effect of multiple components, the present invention takes into account anthelmintic efficiency, repair, and safety, and is suitable for livestock and poultry groups with complex parasitic infections and those in need of rapid recovery. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 is a schematic flow diagram of the present invention; DETAILED DESCRIPTION OF THE INVENTION

[0037] The present invention will be further described below in conjunction with the drawings and embodiments:

[0038] The veterinary drug formula of traditional Chinese medicine components in the prevention of livestock and poultry parasitic diseases is shown in Figure 1 and includes the following raw materials:

[0039] Traditional Chinese medicine components: 10 - 20 g of pumpkin vine, 10 - 15 g of Stemona root, 15 - 25 g of Areca root, 10 - 20 g of Immature Bitter Orange, 10 - 15 g of Carpesium fruit, 10 - 20 g of Scutellaria root, 8 - 12 g of Fructus Cnidii, 8 - 12 g of Bletilla striata, 8 - 12 g of Sanguisorba officinalis, 6 - 10 g of Endothelium Corneum Gigeriae Galli, 8 - 12 g of Sophora flavescens, 8 - 12 g of Agrimonia pilosa, 6 - 10 g of Perilla leaf, 5 - 15 g of Astragalus polysaccharide, 6 - 12 g of Codonopsis pilosula, 6 - 10 g of Licorice root;

[0040] Western medicine components: 0.50 - 1.50 mg of albendazole, 0.01 - 0.03 mg of ivermectin, 0.3 - 0.7 mg of sodium sulfachloropyrazine;

[0041] Auxiliary components: 5 - 15 g of vitamin C, 5 - 10 g of sodium bicarbonate, 10 - 20 g of glucose.

[0042] Specifically, as shown in Figure 1 , the dosages of the traditional Chinese medicine components are 15 g of pumpkin vine, 12 g of Stemona root, 20 g of Areca root, 15 g of Immature Bitter Orange, 12 g of Carpesium fruit, 15 g of Scutellaria root, 10 g of Fructus Cnidii, 10 g of Bletilla striata, 10 g of Sanguisorba officinalis, 8 g of Endothelium Corneum Gigeriae Galli, 10 g of Sophora flavescens, 10 g of Agrimonia pilosa, 8 g of Perilla leaf, 10 g of Astragalus polysaccharide, 8 g of Codonopsis pilosula, and 8 g of Licorice root;

[0043] 20 g of pumpkin vine, 15 g of stemona root, 25 g of areca root, 20 g of immature bitter orange, 15 g of carpesium fruit, 20 g of skullcap root, 12 g of fructus cnidii, 12 g of bletilla tuber, 12 g of burnet root, 10 g of chicken gizzard-membrane, 12 g of lightyellow sophora root, 12 g of hairyvein agrimony herb, 10 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of pilose asiabell root, 10 g of liquorice root;

[0044] 10 g of pumpkin vine, 10 g of stemona root, 15 g of areca root, 10 g of immature bitter orange, 10 g of carpesium fruit, 10 g of skullcap root, 8 g of fructus cnidii, 8 g of bletilla tuber, 8 g of burnet root, 6 g of chicken gizzard-membrane, 8 g of lightyellow sophora root, 8 g of hairyvein agrimony herb, 6 g of perilla leaf, 5 g of astragalus polysaccharide, 6 g of pilose asiabell root, 6 g of liquorice root;

[0045] 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of carpesium fruit, 15 g of skullcap root, 10 g of fructus cnidii, 10 g of bletilla tuber, 10 g of burnet root, 8 g of chicken gizzard-membrane, 10 g of lightyellow sophora root, 10 g of hairyvein agrimony herb, 8 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of pilose asiabell root, 10 g of liquorice root.

[0046] Specifically, refer to Figure 1 , the dosage of the western medicine components is 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, and 0.5 mg / kg body weight of sodium sulfachloropyrazine;

[0047] 1.5 mg / kg body weight of albendazole, 0.03 mg / kg body weight of ivermectin, and 0.7 mg / kg body weight of sodium sulfachloropyrazine;

[0048] 0.5 mg / kg body weight of albendazole, 0.01 mg / kg body weight of ivermectin, and 0.3 mg / kg body weight of sodium sulfachloropyrazine;

[0049] 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, and 0.5 mg / kg body weight of sodium sulfachloropyrazine.

[0050] Furthermore, refer to Figure 1 , the dosage of the auxiliary components is 10 g of vitamin C, 8 g of sodium bicarbonate, and 10 g of glucose;

[0051] 15 g of vitamin C, 10 g of sodium bicarbonate, and 20 g of glucose;

[0052] 5 g of vitamin C, 5 g of sodium bicarbonate, and 10 g of glucose;

[0053] 15 g of vitamin C, 8 g of sodium bicarbonate, and 20 g of glucose.

[0054] Even further, refer to Figure 1 , the total mass ratio of the traditional Chinese medicine components in the formula is 60 - 75%, the total mass ratio of the western medicine components is 15 - 25%, and the total mass ratio of the auxiliary components is 10 - 20%.

[0055] It should be noted that, referring to Figure 1 , the preparation forms of the traditional Chinese medicine component, the western medicine component and the auxiliary component are powder and granule.

[0056] The preparation method of the above veterinary drug formula includes the following steps:

[0057] S1. Weigh the traditional Chinese medicine component according to the proportion, crush it and sieve it, and mix it evenly;

[0058] S2. Weigh the western medicine component according to the proportion and mix it with the traditional Chinese medicine powder in S1;

[0059] S3. Add vitamin C, sodium bicarbonate and glucose, stir evenly and make the target dosage form.

[0060] It should be noted that, referring to Figure 1 , the sieve mesh number in S1 is 80 - 100 meshes, and the mixing time is 20 - 30 min.

[0061] The use of the above veterinary drug formula for preventing parasitic diseases of livestock and poultry.

[0062] Example 1

[0063] Formulation composition:

[0064] Traditional Chinese medicine component: 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of fruit of cnidium monnieri, 15 g of skullcap root, 10 g of fructus cnidii, 10 g of bletilla striata, 10 g of garden burnet root, 8 g of chicken gizzard-membrane, 10 g of lightyellow sophora root, 10 g of hairyvein agrimony, 8 g of perilla leaf, 10 g of astragalus polysaccharide, 8 g of codonopsis pilosula, 8 g of liquorice root;

[0065] Western medicine component: 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, 0.5 mg / kg body weight of sodium sulfachloropyrazine;

[0066] Auxiliary component: 10 g of vitamin C, 8 g of sodium bicarbonate, 10 g of glucose.

[0067] Preparation method:

[0068] S1. Crush the traditional Chinese medicine component and sieve it through 80-mesh sieve, and mix it for 30 minutes;

[0069] S2. Add the western medicine component;

[0070] S3. Add the auxiliary component and make powder.

[0071] Example 2

[0072] Formulation composition:

[0073] Traditional Chinese medicine components: 20 g of pumpkin vine, 15 g of stemona root, 25 g of betel nut root, 20 g of immature bitter orange, 15 g of carpesium fruit, 20 g of scutellaria root, 12 g of cnidium fruit, 12 g of bletilla tuber, 12 g of sanguisorba root, 10 g of chicken gizzard-membrane, 12 g of sophora flavescens, 12 g of agrimony herb, 10 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of codonopsis pilosula, 10 g of liquorice root;

[0074] Western medicine components: 1.5 mg / kg body weight of albendazole, 0.03 mg / kg body weight of ivermectin, 0.7 mg / kg body weight of sodium sulfachloropyrazine;

[0075] Auxiliary components: 15 g of vitamin C, 10 g of sodium bicarbonate, 20 g of glucose.

[0076] Preparation method:

[0077] S1. Crush the traditional Chinese medicine components through a 100-mesh sieve and mix for 20 minutes;

[0078] S2. Add the western medicine components;

[0079] S3. Add the auxiliary components to make granules.

[0080] Example 3

[0081] Formulation composition:

[0082] Traditional Chinese medicine components: 10 g of pumpkin vine, 10 g of stemona root, 15 g of betel nut root, 10 g of immature bitter orange, 10 g of carpesium fruit, 10 g of scutellaria root, 8 g of cnidium fruit, 8 g of bletilla tuber, 8 g of sanguisorba root, 6 g of chicken gizzard-membrane, 8 g of sophora flavescens, 8 g of agrimony herb, 6 g of perilla leaf, 5 g of astragalus polysaccharide, 6 g of codonopsis pilosula, 6 g of liquorice root;

[0083] Western medicine components: 0.5 mg / kg body weight of albendazole, 0.01 mg / kg body weight of ivermectin, 0.3 mg / kg body weight of sodium sulfachloropyrazine;

[0084] Auxiliary components: 5 g of vitamin C, 5 g of sodium bicarbonate, 10 g of glucose.

[0085] Preparation method:

[0086] S1. Crush the traditional Chinese medicine components through an 80-mesh sieve and mix for 25 minutes;

[0087] S2. Add the western medicine components;

[0088] S3. Add the auxiliary components to make oral liquid.

[0089] Example 4

[0090] Formulation composition:

[0091] Traditional Chinese medicine components: 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of carpesium fruit, 15 g of scutellaria baicalensis, 10 g of cnidium fruit, 10 g of bletilla striata, 10 g of sanguisorba officinalis, 8 g of chicken gizzard-membrane, 10 g of sophora flavescens, 10 g of agrimonia pilosa, 8 g of perilla leaf, 15 g of astragalus polysaccharide, 12 g of codonopsis pilosula, 10 g of liquorice root;

[0092] Western medicine components: 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, 0.5 mg / kg body weight of sodium sulfachloropyrazine;

[0093] Auxiliary components: 15 g of vitamin C, 8 g of sodium bicarbonate, 20 g of glucose.

[0094] Preparation method:

[0095] S1. Crush the traditional Chinese medicine components through a 100-mesh sieve and mix for 30 minutes;

[0096] S2. Add the western medicine components;

[0097] S3. Add the auxiliary components to make granules.

[0098] Control example 1

[0099] Formulation composition:

[0100] Traditional Chinese medicine components: 10 g of cortex meliae, 15 g of artemisia annua, 10 g of areca nut, 15 g of garlic, 15 g of stemona root, 10 g of portulaca oleracea, 15 g of dried tangerine peel, 10 g of cyrtomium rhizome, 15 g of pumpkin seed, 15 g of sophora flavescens, 10 g of rhubarb, 15 g of liquorice root;

[0101] Western medicine components: None;

[0102] Auxiliary components: None.

[0103] Preparation method:

[0104] Decoct the traditional Chinese medicine components and concentrate them into a liquid dosage form.

[0105] Control example 2

[0106] Formulation composition:

[0107] Traditional Chinese medicine components: 15 g of pumpkin vine, 12 g of stemona root, 20 g of areca root, 15 g of immature bitter orange, 12 g of carpesium fruit, 15 g of scutellaria baicalensis, 10 g of cnidium fruit, 10 g of sophora flavescens, 10 g of agrimonia pilosa, 8 g of perilla leaf;

[0108] Western medicine components: 0.1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, 0.5 mg / kg body weight of sodium sulfachloropyrazine;

[0109] Auxiliary components: 10 g of vitamin C, 8 g of sodium bicarbonate, 10 g of glucose.

[0110] Preparation method:

[0111] S1. Crush the traditional Chinese medicine components through an 80-mesh sieve and mix for 30 minutes;

[0112] S2. Add the western medicine components;

[0113] S3. Add the auxiliary components to make a powder.

[0114] Comparative Example 3

[0115] Formulation composition:

[0116] Western medicine components: Ivermectin 0.2 mg / kg body weight

[0117] Traditional Chinese medicine components: None

[0118] Auxiliary components: None

[0119] Preparation method:

[0120] S1. Weigh ivermectin and calculate the dosage according to 0.2 mg / kg body weight;

[0121] S2. Directly mix it with the feed to make a powder.

[0122] Comparative Example 4

[0123] Formulation composition:

[0124] Western medicine components: Albendazole 10 mg / kg body weight Traditional Chinese medicine components: None

[0125] Auxiliary components: None

[0126] Preparation method:

[0127] S1. Weigh albendazole and calculate the dosage according to 10 mg / kg body weight;

[0128] S2. Directly mix it with the feed to make a powder.

[0129] Efficacy test

[0130] Test method:

[0131] 1. Experimental subjects: Broiler chickens infected with hookworms and tapeworms (50 in each group).

[0132] 2. Administration scheme: Administer the drug continuously for 7 days, and divide the daily dose into 2 times and mix it into the feed.

[0133] 3. Detection indicators:

[0134] Deworming rate: Dissect and check the number of intestinal parasites on the 7th day after drug administration;

[0135] Intestinal repair: Observe the integrity of the intestinal mucosa through tissue sections;

[0136] Immune function: Detect the levels of serum IgA and IgG;

[0137] Weight recovery: Record the weight changes before and after treatment.

[0138] The specific comparison data are as follows:

[0139]

[0140]

[0141] Conclusion:

[0142] 1. The anthelmintic rates of Examples 1 - 4 are all higher than those of Comparative Example 1 (traditional formula) and Comparative Example 2 (lacking repair components). Among them, the anthelmintic rate of Example 2 (high-dose anthelmintic formula) reaches 99.5%.

[0143] 2. The mucosal repair scores of Examples 1, 2, and 4 are close to the full score (5 points), showing the synergistic effect of repair components such as Bletilla striata and Sanguisorba officinalis; due to the lack of repair components in Comparative Example 2, the score is only 3.0.

[0144] 3. The immune function (IgA, IgG) and weight recovery rate are better in the examples than in the comparative examples, proving the immune-enhancing effect of astragalus polysaccharide and Codonopsis pilosula.

[0145] 4. Due to the lack of western medicine and auxiliary components in Comparative Example 1, the anthelmintic effect and comprehensive recovery ability are the worst.

[0146] 5. Due to the lack of traditional Chinese medicine and auxiliary components in Comparative Example 3 and Comparative Example 4, the anthelmintic rate is high but other indicators are poor.

[0147] The above examples and test data show that the formula of the present invention has obvious advantages in anthelmintic efficiency, intestinal repair, and immune regulation.

[0148] In addition, the components designed in the present invention are all common standard components or components known to those skilled in the art. Their structures and principles can all be learned through technical manuals by those skilled in the art or obtained through conventional experimental methods. Those skilled in the art can fully implement them without further elaboration. The content protected by the present invention does not involve improvements to the internal structure and method.

[0149] The embodiments disclosed in the present invention are preferred embodiments, but not limited thereto. Those of ordinary skill in the art can easily understand the spirit of the present invention based on the above embodiments and make different extensions and changes. However, as long as they do not depart from the spirit of the present invention, they are within the protection scope of the present invention.

Claims

1. A veterinary drug formula for preventing parasitic diseases of livestock and poultry using Chinese herbal medicine ingredients, characterized in that: Including the following ingredients: Chinese medicinal ingredients: pumpkin vine 10-20g, stemona 10-15g, betel nut root 15-25g, immature bitter orange 10-20g, scutellaria 10-20g, cnidium monnieri 8-12g, bletilla striata 8-12g, sanguisorba officinalis 8-12g, chicken gizzard 6-10g, sophora flavescens 8-12g, agrimony 8-12g, perilla leaf 6-10g, astragalus polysaccharide 5-15g, codonopsis pilosula 6-12g, licorice 6-10g; Western medicine components: albendazole 0.50-1.50mg, ivermectin 0.01-0.03mg, sulfachloropyrazine sodium 0.3-0.7mg; Auxiliary ingredients: Vitamin C 5-15g, sodium bicarbonate 5-10g, glucose 10-20g.

2. The veterinary drug formulation according to claim 1, characterized in that The dosage of the Chinese medicinal components is 15g of pumpkin vine, 12g of stemona, 20g of betel nut root, 15g of immature bitter orange, 12g of scutellaria, 15g of baicalin, 10g of cnidium monnieri, 10g of bletilla striata, 10g of sanguisorba officinalis, 8g of chicken gizzard lining, 10g of sophora flavescens, 10g of agrimony, 8g of perilla leaf, 10g of astragalus polysaccharide, 8g of codonopsis pilosula, and 8g of liquorice; Pumpkin vine 20g, Stemona tuberosa 15g, Areca nut root 25g, Citrus aurantium 20g, Heshi 15g, Scutellaria 20g, Cnidium monnieri 12g, Bletilla striata 12g, Sanguisorba officinalis 12g, Gallus gallifolia 10g, Sophora flavescens 12g, Agrimoniae 12g, Perilla leaf 10g, Astragalus polysaccharide 15g, Codonopsis pilosula 12g, Licorice root 10g; Pumpkin vine 10g, Stemona tuberosa 10g, Areca nut root 15g, Citrus aurantium 10g, Helix gracile 10g, Scutellaria 10g, Cnidium monnieri 8g, Bletilla striata 8g, Sanguisorba officinalis 8g, Gallus galli 6g, Sophora flavescens 8g, Agrimoniae 8g, Perilla leaf 6g, Astragalus polysaccharide 5g, Codonopsis pilosula 6g, Licorice root 6g; Pumpkin vine 15g, Stemona 12g, Areca nut root 20g, Citrus aurantium 15g, Gallus officinalis 12g, Scutellaria 15g, Cnidium monnieri 10g, Bletilla striata 10g, Sanguisorba officinalis 10g, Gallus gallifolia 8g, Sophora flavescens 10g, Agrimonia 10g, Perilla leaf 8g, Astragalus polysaccharide 15g, Codonopsis pilosula 12g, Licorice root 10g.

3. The veterinary drug formulation according to claim 1, characterized in that The dosage of the western medicine components is 1 mg / kg body weight of albendazole, 0.02 mg / kg body weight of ivermectin, and 0.5 mg / kg body weight of sulfachloropyrazine sodium; albendazole 1.5 mg / kg body weight, ivermectin 0.03 mg / kg body weight, sulfachloropyrazine sodium 0.7 mg / kg body weight; albendazole 0.5 mg / kg body weight, ivermectin 0.01 mg / kg body weight, sulfachloropyrazine sodium 0.3 mg / kg body weight; Albendazole 1 mg / kg body weight, ivermectin 0.02 mg / kg body weight, sulfachloropyrazine sodium 0.5 mg / kg body weight.

4. The veterinary drug formulation according to claim 1, characterized in that The dosage of the auxiliary ingredients is 10g vitamin C, 8g sodium bicarbonate, and 10g glucose; Vitamin C 15g, sodium bicarbonate 10g, glucose 20g; Vitamin C 5g, sodium bicarbonate 5g, glucose 10g; Vitamin C 15g, sodium bicarbonate 8g, glucose 20g.

5. The veterinary drug formulation according to claim 1, characterized in that: In the formula, the total weight of traditional Chinese medicine components accounts for 60-75%, the total weight of western medicine components accounts for 15-25%, and the total weight of auxiliary ingredients accounts for 10-20%.

6. The veterinary drug formulation according to claim 1, characterized in that: The traditional Chinese medicine components, western medicine components and auxiliary ingredients are prepared in the form of powders and granules.

7. A method for preparing the veterinary drug formulation according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Weigh the Chinese medicine components according to the proportion, crush and sieve, and mix them evenly; S2, weigh the western medicine components according to the proportion and mix them with the Chinese medicine powder in S1; S3. Add vitamin C, sodium bicarbonate and glucose, stir evenly to prepare the target dosage form.

8. The preparation method according to claim 7, characterized in that: The sieving mesh number in S1 is 80-100 mesh, and the mixing time is 20-30 minutes.

9. Use of the veterinary drug formulation according to any one of claims 1 to 6 for preventing parasitic diseases in livestock and poultry.

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