Reversible organ perfusion bin and control method thereof

Abstract

The invention provides a turnover organ perfusion bin which comprises a perfusion bin bottom and a perfusion bin top, and a perfusion bin cavity used for containing organs is formed by the perfusion bin bottom and the perfusion bin top. The pouring bin overturning and adjusting mechanism is connected to the bottom of the pouring bin, and the whole pouring bin overturning and adjusting mechanism is located outside the pouring bin cavity; wherein the perfusion bin turnover adjusting mechanism is used for adjusting the posture of the organ perfusion bin.

Description

Technical Field

[0001] The present application relates to organ perfusion, and more particularly, to a reversible organ perfusion chamber. Background Art

[0002] Organ perfusion is a technology that simulates the in vivo environment to provide oxygen, nutrients and metabolic waste removal to isolated organs. This technology can prolong the storage time of organs before transplantation to avoid damage. Normothermic perfusion technology usually keeps the organs at a close to physiological temperature (generally 35-38°C) to maintain normal metabolic activities of organ cells, and monitors and evaluates organ function during the perfusion process for real-time repair and evaluation. During the normothermic perfusion process, sufficient oxygen, nutrients and metabolic substrates need to be provided to ensure the normal operation of the organs under a high metabolic state.

[0003] The core of organ perfusion technology is to continuously deliver perfusion fluid (usually specially configured oxygenated blood or replacement fluid) to the vascular system within the organ through the extracorporeal circulation system to keep the organ active and functional.

[0004] The organ perfusion chamber is a medical device specifically used to preserve and maintain the function of transplanted organs in vitro and to improve the success rate of transplantation. Its structure and function are designed to simulate the in vivo environment, thereby providing high-quality support for organ transplantation and prolonging the storage time of organs. The organ perfusion chamber is the core device of organ perfusion technology, and its structural design directly affects the preservation effect and organ quality.

[0005] MIT's patent CN 109070082 B discloses a "modular organ microphysiological system with integrated pumping, leveling and sensing", which supports the cultivation of multiple organs in a microphysiological interaction system through pneumatically driven on-board pumping of fluid flow, a redesigned overflow channel with self-leveling from source to sink, a non-contact built-in fluid level sensing device, and precise control of fluid flow profiles and segmentation. However, its structural design is complex and the cost of use is high.

[0006] A lower-cost approach is to set up air bags under the organs to improve the preservation of the organs. For example, patent CN 116195577 B of the Suzhou Institute of Biomedical Engineering and Technology of the Chinese Academy of Sciences discloses "a mechanical perfusion system for in vitro culture and regeneration of organs", in which a simulated air bag is located under the organ pad and connected to the air bag control component outside the chamber by a pipeline. The simulated air bag is inflated and deflated according to a certain pattern and cycle, so that the organ on the organ pad is lifted up and lowered, changing the contact position between the organ and the organ pad, simulating the influence of the lungs and diaphragm on the organ in the body.

[0007] However, the similar way of setting up the airbag can usually only achieve the up-and-down movement of the organ, and often cannot effectively avoid the pressure concentration and poor blood circulation caused by the organ's long-term contact with the support surface. Moreover, the adjusting airbag is located inside the organ chamber, which has problems of organ contamination and inconvenient replacement. Therefore, it is necessary to provide an improved organ perfusion chamber that can dynamically adjust the posture of the organ located in the organ perfusion chamber through an adjusting mechanism outside the organ chamber to improve the blood circulation of the organ and enhance the preservation quality. Summary of the Invention

[0008] The present invention provides an organ perfusion chamber capable of flipping an organ. By providing an adjusting mechanism outside the organ perfusion chamber to adjust the swing of the organ perfusion chamber, the posture of the organ located in the organ perfusion chamber can be dynamically adjusted, thereby improving the blood circulation of the organ and enhancing the preservation quality.

[0009] The adjusting mechanism of the present invention can be arranged outside the organ perfusion chamber and does not need to be operated in a sterile environment, reducing the maintenance and repair costs. In addition, the adjusting mechanism of the present invention can be adapted to the preservation requirements of different organs by setting different parameters, improving the preservation quality of multiple organs.

[0010] A flipable organ perfusion chamber according to an embodiment of the present application includes: a perfusion chamber bottom and a perfusion chamber top, the perfusion chamber bottom and the perfusion chamber top form a perfusion chamber cavity for accommodating an organ; a perfusion chamber flip adjustment mechanism, the perfusion chamber flip adjustment mechanism is connected to the perfusion chamber bottom, and the whole perfusion chamber flip adjustment mechanism is located outside the perfusion chamber cavity; wherein the perfusion chamber flip adjustment mechanism is used to adjust the posture of the organ perfusion chamber. According to the adjusting mechanism of the present invention, it can be arranged outside the organ perfusion chamber, does not come into contact with the organ inside the organ perfusion chamber during operation, and does not need to be operated in a sterile environment. At the same time, it can realize various postures and movement forms of the organ perfusion chamber, thereby driving the corresponding movement of the organ in the organ perfusion chamber.

[0011] The flipable organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flip adjustment mechanism includes: a hinge mechanism, the perfusion chamber bottom is installed on a base through the hinge mechanism; a motor for driving a slider to move along a linear guide rail on the installation base; a dial rod and a connecting rod, the dial rod is connected to the slider, and the dial rod is used to convert the linear movement of the slider into the swing or rotational movement of the connecting rod. The organ perfusion chamber can achieve swing or flip through the perfusion chamber flip adjustment mechanism. During the swing or flip of the organ perfusion chamber, the organ stored in the organ perfusion chamber also rotates by a specific angle or moves at a set speed.

[0012] The organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism makes the rotation angle of the organ perfusion chamber less than 30 degrees. This is suitable for causing slight swinging of the organ, and can effectively avoid pressure concentration and poor blood circulation caused by the organ contacting the support surface for a long time.

[0013] The organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism flips the organ in the organ perfusion chamber up and down. If the organ to be preserved needs to be flipped up and down, the rotation angle of the organ perfusion chamber can be increased, so as to realize the flipping of the upper and lower surfaces of the organ, and there is no need to open the organ perfusion chamber, which greatly simplifies the perfusion operation of some organs that need to be turned over.

[0014] The flipable organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism increases or decreases the swinging speed of the organ perfusion chamber, and can effectively avoid pressure concentration and poor blood circulation caused by the organ contacting the support surface for a long time.

[0015] A method for controlling the attitude of an organ perfusion chamber according to an embodiment of the present application, comprising: providing a perfusion chamber bottom and a perfusion chamber top, the perfusion chamber bottom and the perfusion chamber top forming a perfusion chamber cavity for accommodating an organ; adjusting the attitude of the organ perfusion chamber through a perfusion chamber flipping and adjusting mechanism connected to the perfusion chamber bottom, wherein the perfusion chamber flipping and adjusting mechanism is entirely located outside the perfusion chamber cavity. According to the adjusting mechanism of the present invention, it can be arranged outside the organ perfusion chamber, does not come into contact with the organ inside the organ perfusion chamber during the operation, and does not need to be operated in a sterile environment. At the same time, it can realize various postures and movement forms of the organ perfusion chamber, thereby driving the corresponding movement of the organ in the organ perfusion chamber.

[0016] A method for controlling the attitude of an organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism includes: a hinge mechanism, the perfusion chamber bottom is installed on a base through the hinge mechanism; a motor for driving a slider to move along a linear guide rail on the installation base; a lever and a connecting rod, the lever is connected to the slider, and the lever is used to convert the linear movement of the slider into the swinging or rotational movement of the connecting rod. The organ perfusion chamber can realize swinging or flipping through the perfusion chamber flipping and adjusting mechanism. During the swinging or flipping of the organ perfusion chamber, the organ stored in the organ perfusion chamber also rotates a specific angle or moves at a set speed accordingly.

[0017] A method for controlling the attitude of an organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism makes the rotation angle of the organ perfusion chamber less than 30 degrees. This is suitable for causing slight swinging of the organ, and can effectively avoid pressure concentration and poor blood circulation caused by the organ contacting the support surface for a long time.

[0018] A method for controlling the attitude of an organ perfusion chamber according to an embodiment of the present application, wherein: the perfusion chamber flipping and adjusting mechanism flips the organ in the organ perfusion chamber up and down. If the organ to be preserved needs to be flipped up and down, the rotation angle of the organ perfusion chamber can be increased, so as to realize the flipping of the upper and lower surfaces of the organ, and it is not necessary to open the organ perfusion chamber, which greatly simplifies the perfusion operation of some organs that need to be turned over.

[0019] A method for controlling the attitude of an organ perfusion chamber according to an embodiment of the present application, wherein:

[0020] The perfusion chamber flipping and adjusting mechanism increases or decreases the swinging speed of the organ perfusion chamber, which can effectively avoid pressure concentration and poor blood circulation caused by the organ contacting the support surface for a long time.

[0021] The solution of the present invention provides a simple, precise and effective flipable organ perfusion chamber, which is suitable for preserving and maintaining the function of transplanted organs and improving the transplantation success rate. It can move and flip the organ perfusion chamber and the organs stored therein according to different needs, and can reduce the direct contact with the organs stored inside the organ perfusion chamber, thereby greatly reducing the risk of organ contamination. Therefore, the assembly process is simplified and possible contamination and complex sterilization operations are avoided. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to illustrate the embodiments of the present application more clearly, the embodiments of the present application will be described below in conjunction with the drawings. The drawings are only schematic, and the shapes, sizes and positional relationships shown in the drawings are only examples and cannot limit the scope of protection required by the present application.

[0023] Figure 1 A schematic diagram of an organ perfusion chamber according to the present invention is shown.

[0024] Figure 2 A schematic diagram of a perfusion chamber flipping and adjusting mechanism according to an embodiment of the present invention is shown. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] The technical solutions of the present invention will be described below in conjunction with the drawings. It should be understood that the described embodiments are only partial embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts shall fall within the scope of protection of the present invention. In the following description, the connection between devices can be either direct connection or connection through other devices; the positional relationship and size of each component are only schematic and are not limited to the manner shown in the drawings.

[0026] Figure 1It is a schematic diagram of an organ perfusion chamber 10 for organ perfusion. The organ (not shown) placed in the organ perfusion chamber 10 can be an organ or tissue of a human or animal, can be a natural or artificial organ or tissue, and can be a healthy or diseased organ or tissue. For example, it can be a liver, kidney, heart, lung or intestine. The organ is preserved in the perfusion chamber 10 and maintains its own metabolic state. The organ perfusion chamber 10 provides stable oxygen supply and nutrients for the organ while reducing the risk of infection.

[0027] As Figure 1 shown, the organ perfusion chamber 10 includes a perfusion chamber bottom 20 and a perfusion chamber top 30. The perfusion chamber bottom 20 and the perfusion chamber top 30 form a perfusion chamber cavity for accommodating the organ. The perfusion chamber cavity is usually made of a non-toxic and corrosion-resistant material (such as medical-grade stainless steel or polymer material) to ensure sterility and chemical stability. The inside of the perfusion chamber cavity is a sterile and disinfected environment, and the outside of the perfusion chamber cavity can be a non-sterile and non-disinfected environment. The organ (not shown) being perfused in the organ perfusion chamber 10 can be put in and taken out through the perfusion chamber top 30, for example.

[0028] The organ perfusion chamber 10 cooperates with other modules to provide a controllable and precise in vitro organ survival environment. As an important device for organ preservation and evaluation, the organ perfusion chamber is designed with a variety of interfaces to achieve precise control of the perfusion process, data acquisition, environmental regulation, and organ fixation and protection. The organ perfusion chamber 10 includes a perfusion fluid input interface for delivering a pre-prepared perfusion fluid or preservation fluid into the organ perfusion chamber; a perfusion fluid output interface for discharging metabolites or excess fluid generated after organ perfusion to ensure smooth liquid circulation in the system. The organ perfusion chamber 10 also includes an oxygen input interface for injecting oxygen into the perfusion fluid or directly delivering oxygen to the organ to ensure normal cell respiration and energy metabolism. The organ perfusion chamber 10 includes an organ fixation and positioning device for fixing and holding the organ. The organ fixation and positioning device may include clamps, trays or other fixing devices to ensure the proper position of the organ in the perfusion fluid. The organ fixation and positioning device can be adjusted to adapt to different organ sizes and shapes.

[0029] The perfusion chamber bottom 20 is connected to a perfusion chamber flipping and adjusting mechanism 40 at the other end opposite to the top of the perfusion chamber top 30. The perfusion chamber flipping and adjusting mechanism 40 is entirely located outside the perfusion chamber cavity. Through the perfusion chamber flipping and adjusting mechanism 40, the organ perfusion chamber 10 can swing or flip, thereby adjusting the posture (angle or speed) of the organ perfusion chamber 10. Through parameter settings, the organ perfusion chamber 10 can rotate within a specific range of angles or achieve continuous movement at a specific speed. It should be noted that the perfusion chamber flipping and adjusting mechanism 40 does not come into contact with the organ located inside the organ perfusion chamber 10 during operation.

[0030] Figure 2 An embodiment of the perfusion chamber tilting and adjusting mechanism 40 is shown. As Figure 2 shown, the perfusion chamber tilting and adjusting mechanism 40 includes a hinge mechanism 41, a motor 42, a lever 45, and a connecting rod 46. The bottom 20 of the perfusion chamber is mounted on the base through the hinge mechanism 41. The hinge mechanism 41 can be symmetrically arranged on the bottom 20 of the perfusion chamber and is used to enable the bottom 20 of the perfusion chamber to perform single-axis swinging. The hinge 30 has a fixed rotation axis and is used to limit the organ perfusion chamber 10 to swing around a specific axis. Preferably, the trajectory of the swinging motion is in an arc shape. In addition, as Figure 2 shown, the motor 42 drives the slider 43 to move along the linear guide rail 44 on the mounting base, which is driven by a transmission device (such as a lead screw or a rack) to provide an initial linear motion. The lever 45 is connected to the slider 43, and the lever 45 is used to convert the linear motion of the slider 43 into the swinging or rotational motion of the connecting rod 46. The shape and structure of the lever 45 determine the efficiency and trajectory of the motion conversion.

[0031] In this embodiment, the slider 43 is driven by a transmission device and reciprocates linearly on the guide rail 44. The motion of the slider 43 drives the lever 45, and the lever 45 converts the linear thrust into a swinging or rotational motion along a curved trajectory through a specific geometric design (such as an eccentric shaft or an arc-shaped groove). Preferably, the contact surface between the slider 43 and the lever 45 should reduce friction, and rollers or lubrication devices can be added if necessary.

[0032] The organ perfusion chamber 10 can achieve swinging or tilting through the perfusion chamber tilting and adjusting mechanism 40. During the swinging or tilting process of the organ perfusion chamber 10, the organs stored in the organ perfusion chamber 10 also rotate by a specific angle or move at a set speed. According to the specific requirements of the stored organs, the rotation angle of the organ perfusion chamber 10 and the organs therein can be less than 90 degrees, specifically, less than 30 degrees. If the stored organs need to be turned upside down, the rotation angle of the organ perfusion chamber 10 can be greater than 90 degrees, so as to realize the turning of the upper and lower surfaces of the organs without opening the organ perfusion chamber 10. In addition, according to the metabolic parameters of the stored organs, the swinging speed of the organ perfusion chamber 10 can be set, and when the organ metabolism is vigorous, the swinging speed of the organ perfusion chamber 10 can be increased.

[0033] According to another embodiment, the lever 45 can be an eccentric structure lever. The slider pushes the lever, and the lever generates an eccentric motion near the rotation axis, finally forming an arc swing. The slider 43 is driven by a transmission device and reciprocates linearly on the guide rail 44. The motion of the slider 43 drives the lever 45, and the lever 45 converts the linear thrust into a swinging or rotational motion along a curved trajectory through the eccentric structure.

[0034] According to another embodiment, the lever 45 can be an arc-shaped groove lever. The slider drives the lever to slide, and the sliding range of the lever is restricted by the arc-shaped groove, thus being converted into a curvilinear motion. The slider 43 is driven by a transmission device and reciprocates linearly on the guide rail 44. The movement of the slider 43 drives the lever 45, and the lever 45 converts the linear thrust into a swinging or rotating motion along a curvilinear trajectory through the arc-shaped groove structure.

[0035] In addition, the perfusion chamber flipping and adjusting mechanism 40 can also adopt other structural designs. For example, the perfusion chamber flipping and adjusting mechanism 40 can be a four-bar linkage mechanism, which is formed by connecting four rigid members through four rotating pairs to form a closed linkage chain. Among them, one of the linkages is fixed as the frame, and the other three linkages are respectively used as the crank, rocker, and connecting rod. They jointly achieve the transmission and conversion of the input motion to the output motion through hinge connections, thereby realizing continuous rotation or reciprocating swinging motion and realizing the functions of force amplification or speed transformation.

[0036] Similarly, those skilled in the art can also design other structures of the perfusion chamber flipping and adjusting mechanism 40 to achieve similar functions.

[0037] The solution of the present invention provides a simple, accurate, and effective flipable organ perfusion chamber, which is suitable for preserving and maintaining the functions of transplanted organs and improving the transplantation success rate. It can move and flip the organ perfusion chamber and the organs stored therein according to different needs, and can reduce the direct contact with the organs stored inside the organ perfusion chamber, thereby greatly reducing the risk of organ contamination.

[0038] Those skilled in the art can understand that various modifications, combinations, or substitutions can be made within the scope of the appended claims or their equivalents based on design requirements and other factors.

Claims

1. A reversible organ perfusion chamber, comprising: A perfusion chamber bottom and a perfusion chamber top, the perfusion chamber bottom and the perfusion chamber top forming a perfusion chamber cavity for accommodating an organ; A perfusion chamber flipping and adjusting mechanism, the perfusion chamber flipping and adjusting mechanism being connected to the perfusion chamber bottom, and the perfusion chamber flipping and adjusting mechanism being entirely located outside the perfusion chamber cavity; Wherein The perfusion chamber flipping and adjusting mechanism is used to adjust the attitude of the organ perfusion chamber.

2. The reversible organ perfusion chamber according to claim 1, wherein: The perfusion chamber flipping and adjusting mechanism includes: A hinge mechanism, the perfusion chamber bottom being mounted on a base through the hinge mechanism; A motor for driving a slider to move along a linear guide on the mounting base; A lever and a connecting rod, the lever being connected to the slider, the lever being used to convert the linear motion of the slider into a swinging or rotating motion of the connecting rod.

3. The reversible organ perfusion chamber according to claim 1 or 2, wherein: The perfusion chamber flipping and adjusting mechanism makes the rotation angle of the organ perfusion chamber less than 30 degrees.

4. The reversible organ perfusion chamber according to claim 1 or 2, wherein: The rotation angle of the perfusion chamber flipping and adjusting mechanism causes the organ in the organ perfusion chamber to be flipped up and down.

5. The reversible organ perfusion chamber according to claim 1 or 2, wherein: The perfusion chamber flipping and adjusting mechanism increases or decreases the swinging speed of the organ perfusion chamber.

6. A method for controlling the attitude of an organ perfusion chamber, comprising: Providing a perfusion chamber bottom and a perfusion chamber top, the perfusion chamber bottom and the perfusion chamber top forming a perfusion chamber cavity for accommodating an organ; Adjusting the attitude of the organ perfusion chamber through a perfusion chamber flipping and adjusting mechanism connected to the perfusion chamber bottom, wherein the perfusion chamber flipping and adjusting mechanism is entirely located outside the perfusion chamber cavity.

7. The method for controlling the attitude of an organ perfusion chamber according to claim 6, wherein: The perfusion chamber flipping and adjusting mechanism includes: A hinge mechanism, the perfusion chamber bottom being mounted on a base through the hinge mechanism; A motor for driving a slider to move along a linear guide on the mounting base; A lever and a connecting rod, the lever being connected to the slider, the lever being used to convert the linear motion of the slider into a swinging or rotating motion of the connecting rod.

8. The method for controlling the attitude of an organ perfusion chamber according to claim 6 or 7, wherein: The perfusion chamber flipping and adjusting mechanism makes the rotation angle of the organ in the organ perfusion chamber less than 30 degrees.

9. The method for controlling the attitude of an organ perfusion chamber according to claim 6 or 7, wherein: The perfusion chamber flipping and adjusting mechanism causes the organ in the organ perfusion chamber to be flipped up and down.

10. The method for controlling the attitude of an organ perfusion chamber according to claim 6 or 7, wherein: The perfusion chamber flipping and adjusting mechanism increases or decreases the swinging speed of the organ perfusion chamber.

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