Bacteriostatic fragrance-retaining shower gel and preparation method thereof

Abstract

The invention discloses antibacterial fragrance-retaining shower gel and a preparation method thereof, and relates to the technical field of washing products. Comprising the following steps: uniformly mixing cocamidopropyl betaine, glyceryl laurate and disodium ethylene diamine tetraacetate at 58-62 DEG C, then adding an aloe dispersion liquid, carrying out emulsification treatment, adding a carrier dispersion liquid after the temperature is reduced to 40-45 DEG C, uniformly stirring, then adding fragrance-retaining particles, a combined traditional Chinese medicine extract and rosmarinic acid after the temperature is reduced to 30-40 DEG C, and uniformly stirring, so as to obtain a finished product. Adjusting the pH value to 5.5-6.0 by using a citric acid solution, and finally homogenizing, standing, defoaming and filtering to obtain the antibacterial fragrance-retaining shower gel. By introducing the antibacterial carrier and the fragrance-retaining particles, the antibacterial, fragrance-retaining and moisturizing capabilities and storage stability of the shower gel are effectively improved; the antibacterial activity is further improved by introducing coptis chinensis, fructus cnidii, smoked plum and other extracts in the combined traditional Chinese medicine extract. Therefore, the method has a wider application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of washing and chemical products, and particularly relates to an antibacterial and fragrance - retaining body wash and a preparation method thereof. Background Art

[0002] A body wash, also known as body lotion, is a liquid cleaning agent used when taking a bath. Body washes have good foaming properties, and the rich and dense foam produced weakens the adhesion of dirt, grease and the skin, thus achieving the effect of cleaning the skin. Some body washes are added with ingredients such as moisturizers, which can inhibit bacteria, help the skin retain moisture, make the skin more delicate and smooth, and leave a faint fragrance on the skin after bathing. Existing body washes are divided into three types: fatty acid salt - based body washes, synthetic surfactant - based body washes, and compound body washes. Among them, compound body washes combine the advantages of fatty acid salts and synthetic surfactants, retaining both excellent cleaning power and rich foam, and also having the characteristics of mildness and low irritation. However, existing body washes cannot simultaneously have good moisturizing, antibacterial and fragrance - retaining functions, so the comprehensive effect is still difficult to meet the increasing bathing and skin - care needs of various consumers.

[0003] In order to improve the comprehensive performance of body washes, relevant researchers have proposed various solutions. For example, a kind of agarwood body wash with antibacterial and firming effects and its preparation method and application proposed in the patent technical literature CN118415931 B is prepared from components such as agarwood extract, compound enzymatic hydrolysate of agarwood and Selaginella uncinata, extract of Prinsepia uniflora, extract of Eryngium foetidum, disodium ethylenediaminetetraacetate, etc.; by adding extracts that are reasonably formulated and have little impact on the foam system, this body wash has better antibacterial and firming effects and fragrance - retaining property.

[0004] However, the comprehensive effects of storage stability, moisturizing property, antibacterial property and fragrance - retaining property of body washes prepared by these existing technical methods still need to be improved. Summary of the Invention

[0005] The purpose of the present invention is to provide an antibacterial and fragrance - retaining body wash and a preparation method thereof, and solve the following technical problems:

[0006] The problem that the comprehensive effects of storage stability, moisturizing property, antibacterial property and fragrance - retaining property of existing body washes are not ideal.

[0007] The purpose of the present invention can be achieved by the following technical solutions:

[0008] A preparation method of an antibacterial and fragrance - retaining body wash, comprising the following steps:

[0009] At 58 - 62 °C, mix cocamidopropyl betaine, glycerol laurate, and disodium ethylenediaminetetraacetate. Then add the aloe vera dispersion and perform emulsification. After cooling to 40 - 45 °C, add the carrier dispersion and stir well. After cooling to 30 - 40 °C, add the fragrance - retaining particles, combined traditional Chinese medicine extract, and rosmarinic acid and stir well. Then adjust the pH to 5.5 - 6.0 with a citric acid solution. Finally, through homogenization, static defoaming, and filtration, an antibacterial and fragrance - retaining body wash is obtained.

[0010] Preferably, the dosage ratio of cocamidopropyl betaine, glycerol laurate, disodium ethylenediaminetetraacetate, aloe vera dispersion, carrier dispersion, fragrance - retaining particles, combined traditional Chinese medicine extract, and rosmarinic acid is 12 - 14.4 g : 5 - 6 g : 0.2 - 0.24 g : 60 - 72 mL : 6 - 7.2 g : 2 - 2.4 g : 14.5 - 17.4 g : 0.3 - 0.36 g;

[0011] The rotation speed during emulsification is 4800 - 5000 r / min, and the duration is 10 - 15 min.

[0012] Preferably, the preparation method of the carrier dispersion is as follows:

[0013] Step A1: Mix ethanol and deionized water, add nano - zinc oxide, perform ultrasonic treatment, then add tetraethyl orthosilicate, and while stirring, dropwise add ammonia water at 48 - 50 °C. After reacting for 4 - 5 h, perform centrifugation, and finally, through washing and vacuum drying, obtain pretreated zinc oxide;

[0014] Step A2: Disperse the pretreated zinc oxide in ethanol, then add γ - aminopropyltriethoxysilane and reflux at 70 - 75 °C for 6 - 7 h. After centrifugal separation and drying, obtain modified zinc oxide;

[0015] Step A3: Sequentially add tea tree oil and ethanol to the modified zinc oxide, then perform ultrasonic - assisted reaction at 35 - 40 °C. After centrifugation and drying, obtain an antibacterial carrier;

[0016] Step A4: Disperse the antibacterial carrier in glycerol and grind to obtain the carrier dispersion.

[0017] Preferably, the dosage ratio of ethanol, deionized water, nano - zinc oxide, tetraethyl orthosilicate, and ammonia water in Step A1 is 100 - 200 mL : 25 - 50 mL : 5 - 10 g : 4 - 8 mL : 2.5 - 5 mL;

[0018] The mass fraction of ammonia water in Step A1 is 25% - 28%;

[0019] In step A2, the dosage ratio of the pretreated zinc oxide, ethanol, and γ-aminopropyltriethoxysilane is 5-10 g: 50-100 mL: 1-2 mL.

[0020] Preferably, in step A3, the dosage ratio of the modified zinc oxide, tea tree oil, and ethanol is 5-10 g: 1-3 g: 25-50 mL;

[0021] In step A3, the ultrasonic power during the ultrasonic-assisted reaction is 180-200 W, the ultrasonic frequency is 35-40 kHz, and the reaction duration is 2-3 h;

[0022] In step A4, the dosage ratio of the antibacterial carrier and glycerol is 5-10 g: 15-30 g.

[0023] Preferably, the preparation method of the fragrance-retaining particles is as follows:

[0024] Step B1: Dissolve vanillin in ethanol to obtain a vanillin solution;

[0025] Step B2: Dissolve β-cyclodextrin in deionized water at 55-60 °C, then add the vanillin solution dropwise at 40-45 °C and perform ultrasonic treatment. After standing for 12-15 h, add polyethylene glycol diglycidyl ether, adjust the pH to 8.8-9.2, and stir and react at 45-50 °C for 4-5 h. Then, perform freeze-drying, pulverization, and sieving treatments to obtain the fragrance-retaining particles.

[0026] Preferably, in step B1, the dosage ratio of vanillin and ethanol is 2-3 g: 8-12 g;

[0027] In step B2, the dosage ratio of β-cyclodextrin, deionized water, vanillin solution, and polyethylene glycol diglycidyl ether is 10-15 g: 90-135 g: 8-12 g: 2-3 g.

[0028] Preferably, the preparation method of the combined traditional Chinese medicine extract is as follows:

[0029] Step C1: Ultrafinely pulverize Coptis chinensis Franch. and Fructus Cnidii, mix them with deionized water, extract at 50-70 °C for 2-4 h, filter to obtain the first extract and the first filter residue. Then, add Fructus Mume, Acorus tatarinowii Schott, and aqueous ethanol solution to the first filter residue, extract at 63-68 °C for 2-4 h, and filter to obtain the second extract and the second filter residue;

[0030] Step C2: Mix the first extract and the second extract to obtain the combined traditional Chinese medicine extract.

[0031] Preferably, the dosage ratio of Coptis chinensis, Cnidium monnieri, deionized water, Chinese smoked plum, Acorus tatarinowii, and ethanol aqueous solution in step C1 is 40-60 g: 5-15 g: 450-750 mL: 15-25 g: 15-25 g: 375-1250 mL;

[0032] The mass fraction of the ethanol aqueous solution described in step C1 is 60%-70%;

[0033] The dosage ratio of the first extract and the second extract described in step C2 is 9-15 mL: 7.5-25 mL.

[0034] Preferably, the preparation method of the aloe dispersant is as follows:

[0035] Add 3-5 g of aloe vera gel to 60-100 mL of deionized water and stir evenly to obtain an aloe dispersant.

[0036] As a further solution of the present invention.

[0037] The beneficial effects of the present invention:

[0038] The present invention provides an antibacterial and fragrance-retaining body wash and a preparation method thereof. The present invention effectively improves the antibacterial property, fragrance-retaining ability, moisturizing ability, and storage stability of the antibacterial and fragrance-retaining body wash through the following methods.

[0039] (1) In the present invention, a mesoporous silica layer is coated on the surface of nano-zinc oxide by the sol-gel method, which improves the dispersibility of the antibacterial carrier and its compatibility with the surfactant, and loads tea tree oil on the modified zinc oxide, enabling the slow release of tea tree oil and realizing the dual mechanisms of contact sterilization and volatile antibacterial of plant essential oils, greatly enhancing the antibacterial ability and antibacterial duration of the body wash. Pretreatment and other processes effectively inhibit the precipitation, stratification, etc. of zinc oxide, as well as the oxidation and volatilization of tea tree oil during storage, thereby improving the storage stability of the body wash and the uniformity of its texture. At the same time, the present invention also disperses the antibacterial carrier that can form a protective film on the skin surface to reduce the loss of skin moisture in glycerol that can absorb moisture in the air, further improving the moisturizing and nourishing performance of the body wash.

[0040] (2) In the preparation process of the fragrance-retaining particles of the present invention, an ultrasonic-assisted inclusion technology is adopted to embed vanillin molecules into the cavity of cyclodextrin, and crosslink them with polyethylene glycol diglycidyl ether to form a more stable three-dimensional network structure, realizing pH-responsive slow release (gradually releasing in water and accelerating release in the weakly acidic environment on the skin surface), effectively improving the stability of vanillin in the body wash, and ensuring the uniformity of the body wash during storage and use. This also enables vanillin not to volatilize rapidly during the use of the body wash, but to be slowly released over time, thereby prolonging the stability and duration of the fragrance on the skin surface after bathing. Moreover, the fragrance-retaining particles will produce a synergistic effect with components such as antibacterial carriers and combined traditional Chinese medicine extracts, making the smell of the body wash fresher, more pleasant and layered, while further improving the moisturizing, antibacterial, fragrance-retaining and storage stability of the body wash.

[0041] (3) Coptis chinensis in the combined traditional Chinese medicine extracts of the present invention has the effects of clearing heat and drying dampness, purging fire and detoxifying; Cnidium monnieri can dry dampness and dispel wind, kill insects and relieve itching; Fructus Mume can astringe the lung and intestine, promote the production of body fluid and arrest worms; Acorus tatarinowii can open orifices and resolve phlegm, restore consciousness and improve intelligence, promote digestion with the function of removing dampness; and all of them have antibacterial effects and can also produce synergistic effects. In the present invention, they are compounded in a specific ratio and then extracted twice and repeatedly to maximize the inhibitory effect of the combined traditional Chinese medicine extracts on harmful pathogens; at the same time, it can also improve the ability of the body wash to relieve skin itching, inflammation and maintain the activity of beneficial bacteria on the skin surface.

[0042] Therefore, the antibacterial and fragrance-retaining body wash prepared by the present invention has more excellent antibacterial properties, fragrance-retaining ability, moisturizing ability and storage stability, as well as broad application prospects. Detailed implementation manners

[0043] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0044] The properties and sources of some raw materials in the present invention are as follows:

[0045] Nano zinc oxide (purity 99.9%, particle size 30nm) was purchased from Shanghai Hansi Chemical Co., Ltd., CAS: 1314-13-2; tea tree oil (terpinene 40%) was purchased from Nanjing Bermuda Biotechnology Co., Ltd., CAS: 68647-73-4; polyethylene glycol diglycidyl ether (Mn = 500) was purchased from Shanghai Jieshikai Biotechnology Co., Ltd., CAS: 72207-80-8; aloe vera gel (purity 99%) was purchased from Hebei Qiansheng Biotechnology Co., Ltd., CAS: 1415-73-2.

[0046] Example 1: The preparation method of an antibacterial and fragrance - retaining body wash is as follows:

[0047] S1: Mix 100 mL of ethanol with 25 mL of deionized water, add 5 g of nano - zinc oxide, then perform ultrasonic treatment at a power of 250 W and a frequency of 38 kHz for 25 min, add 4 mL of tetraethyl orthosilicate, and while stirring at 500 r / min and dropping 2.5 mL of 25% ammonia water at a rate of 1 mL / min at 48 °C, react for 4 h, then centrifuge at 7500 r / min for 10 min, and finally wash with ethanol 3 times and perform vacuum drying at 55 °C to obtain pretreated zinc oxide;

[0048] S2: Disperse 5 g of pretreated zinc oxide in 50 mL of ethanol, then add 1 mL of γ - aminopropyltriethoxysilane and reflux at 70 °C for 6 h, after centrifugal separation, dry at 55 °C to obtain modified zinc oxide;

[0049] S3: Sequentially add 1 g of tea tree oil and 25 mL of ethanol to 5 g of modified zinc oxide, then perform ultrasonic - assisted reaction at a power of 180 W and a frequency of 35 kHz for 2 h at 35 °C, and then perform centrifugation and drying to obtain an antibacterial carrier;

[0050] S4: Dissolve 2 g of vanillin in 8 g of ethanol to obtain a vanillin solution;

[0051] S5: Dissolve 10 g of β - cyclodextrin in 90 g of deionized water at 55 °C, then drop 8 g of vanillin solution at a rate of 1 mL / min at 40 °C and perform ultrasonic treatment at a power of 200 W for 30 min, let it stand for 12 h, add 2 g of polyethylene glycol diglycidyl ether, adjust the pH to 8.8 with 0.1 mol / L NaOH solution, stir and react at 45 °C for 4 h, perform freeze - drying treatment, crush and pass through a 200 - mesh sieve to obtain fragrance - retaining microparticles;

[0052] S6: Ultrafinely pulverize 40 g of Coptis chinensis and 5 g of Fructus Cnidii, mix them with 450 mL of deionized water, extract at 50 °C for 2 h, filter to obtain the first extract and the first filter residue, then add 15 g of Fructus Mume, 15 g of Acorus tatarinowii and 375 mL of 60% ethanol aqueous solution to the first filter residue, extract at 63 °C for 2 h, filter to obtain the second extract and the second filter residue;

[0053] S7: Mix 9 mL of the first extract with 7.5 mL of the second extract to obtain a combined traditional Chinese medicine extract;

[0054] S8: Disperse 5 g of antibacterial carrier in 15 g of glycerol, then grind to a D50 particle size of 150 nm to obtain a carrier dispersion;

[0055] S9: Add 3 g of aloe vera gel to 60 mL of deionized water and stir evenly to obtain an aloe vera dispersion;

[0056] S10: At 58 °C, mix 12 g of cocamidopropyl betaine, 5 g of glyceryl laurate, and 0.2 g of disodium ethylenediaminetetraacetate and stir at 280 r / min for 15 min. Then add 60 mL of the aloe vera dispersion and emulsify at 58 °C at 4800 r / min for 10 min. After cooling to 40 °C, add 6 g of the carrier dispersion and stir at 350 r / min for 15 min. After cooling to 30 °C, add 2 g of the fragrance-retaining particles, 14.5 g of the combined traditional Chinese medicine extract, and 0.3 g of rosmarinic acid and stir at 180 r / min for 10 min. Then adjust the pH to 5.5 with a 10% citric acid solution, perform a homogenization treatment at 25 °C and 20 MPa with a flow rate of 10 L / min and a circulation times of 2, and finally let it stand and defoam at a vacuum degree of -0.08 MPa for 30 min. After filtering through a 0.22 μm filter membrane, an antibacterial and fragrance-retaining body wash is obtained.

[0057] Example 2: A method for preparing an antibacterial and fragrance-retaining body wash is as follows:

[0058] S1: Mix 150 mL of ethanol and 37.5 mL of deionized water, add 7.5 g of nano-zinc oxide, then perform ultrasonic treatment at a power of 300 W and a frequency of 39 kHz for 28 min, add 6 mL of tetraethyl orthosilicate, and while stirring at 550 r / min at 49 °C, dropwise add 4 mL of 26% ammonia water at a rate of 1 mL / min. After reacting for 4.5 h, centrifuge at 7800 r / min for 10 min, and finally perform vacuum drying treatment at 58 °C after washing 4 times with ethanol to obtain pretreated zinc oxide;

[0059] S2: Disperse 7.5 g of pretreated zinc oxide in 75 mL of ethanol, then add 1.5 mL of γ-aminopropyltriethoxysilane and reflux at 73 °C for 6.5 h. After centrifugal separation, dry at 58 °C to obtain modified zinc oxide;

[0060] S3: Add 2 g of tea tree oil and 37.5 mL of ethanol to 7.5 g of modified zinc oxide in sequence, then perform ultrasonic-assisted reaction at 38 °C with a power of 190 W and a frequency of 38 kHz for 2.5 h, and then perform centrifugation and drying treatment to obtain an antibacterial carrier;

[0061] S4: Dissolve 2.5 g of vanillin in 10 g of ethanol to obtain a vanillin solution;

[0062] S5: Dissolve 12.5 g of β-cyclodextrin in 112.5 g of deionized water at 58 °C. Then, dropwise add 10 g of vanillin solution at a rate of 1.5 mL / min at 43 °C and perform ultrasonic treatment at a power of 230 W for 35 min. After standing for 14 h, add 2.5 g of polyethylene glycol diglycidyl ether. Adjust the pH to 9 with 0.1 mol / L NaOH solution and stir and react at 48 °C for 4.5 h. After freeze-drying treatment, pulverize and pass through a 200-mesh sieve to obtain the fragrance-retaining microparticles;

[0063] S6: Ultrafinely pulverize 50 g of Coptis chinensis and 10 g of Fructus Cnidii and mix them with 600 mL of deionized water. Extract at 60 °C for 3 h. After filtration, obtain the first extract and the first filter residue. Then, add 20 g of Fructus Mume, 20 g of Rhizoma Acori Tatarinowii, and 812.5 mL of an ethanol aqueous solution with a mass fraction of 65% to the first filter residue. Extract at 65 °C for 3 h. After filtration, obtain the second extract and the second filter residue;

[0064] S7: Mix 12 mL of the first extract with 16.25 mL of the second extract to obtain the combined traditional Chinese medicine extract;

[0065] S8: Disperse 7.5 g of the antibacterial carrier in 22.5 g of glycerol, and then grind it to a D50 particle size of 175 nm to obtain the carrier dispersion;

[0066] S9: Add 4 g of aloe vera gel to 80 mL of deionized water and stir evenly to obtain the aloe dispersion;

[0067] S10: At 60 °C, mix 13.2 g of cocamidopropyl betaine, 5.5 g of glycerol laurate, and 0.22 g of disodium ethylenediaminetetraacetate and stir at 290 r / min for 18 min. Then, add 66 mL of the aloe dispersion and emulsify at 60 °C at 4900 r / min for 13 min. Cool down to 43 °C, add 6.6 g of the carrier dispersion and stir at 380 r / min for 18 min. Cool down to 35 °C, add 2.2 g of the fragrance-retaining microparticles, 15.95 g of the combined traditional Chinese medicine extract, and 0.33 g of rosmarinic acid and stir at 190 r / min for 15 min. Then, adjust the pH to 5.8 with a 10% citric acid solution. Perform a homogenization treatment at a flow rate of 10 L / min and a circulation number of 2 at 28 °C and 20 MPa. Finally, stand and defoam at a vacuum degree of -0.08 MPa for 45 min. After filtration through a 0.22-μm filter membrane, obtain the antibacterial and fragrance-retaining body wash.

[0068] Example 3: A preparation method of an antibacterial and fragrance-retaining body wash is as follows:

[0069] S1: Mix 200 mL of ethanol with 50 mL of deionized water, add 10 g of nano-zinc oxide, then perform ultrasonic treatment at a power of 350 W and a frequency of 40 kHz for 30 min, add 8 mL of tetraethyl orthosilicate, and while stirring at 600 r / min at 50 °C, dropwise add 5 mL of 28% ammonia water at a rate of 1 mL / min. After reacting for 5 h, centrifuge at 8000 r / min for 10 min, and finally wash with ethanol 5 times and perform vacuum drying at 60 °C to obtain pretreated zinc oxide;

[0070] S2: Disperse 10 g of pretreated zinc oxide in 100 mL of ethanol, then add 2 mL of γ-aminopropyltriethoxysilane and reflux at 75 °C for 7 h. After centrifugal separation, dry at 60 °C to obtain modified zinc oxide;

[0071] S3: Add 3 g of tea tree oil and 50 mL of ethanol to 10 g of modified zinc oxide in sequence, then perform ultrasonic-assisted reaction at 40 °C with a power of 200 W and a frequency of 40 kHz for 2 - 3 h, and then perform centrifugation and drying to obtain an antibacterial carrier;

[0072] S4: Dissolve 3 g of vanillin in 12 g of ethanol to obtain a vanillin solution;

[0073] S5: Dissolve 15 g of β-cyclodextrin in 135 g of deionized water at 60 °C, then dropwise add 12 g of vanillin solution at a rate of 2 mL / min at 45 °C and perform ultrasonic treatment at a power of 250 W for 40 min. After standing for 15 h, add 3 g of polyethylene glycol diglycidyl ether, adjust the pH to 9.2 with 0.1 mol / L NaOH solution, stir and react at 50 °C for 5 h, perform freeze-drying treatment, crush and pass through a 200-mesh sieve to obtain fragrance-retaining microparticles;

[0074] S6: Ultrafinely crush 60 g of Coptis chinensis and 15 g of Fructus Cnidii, mix them with 750 mL of deionized water, extract at 70 °C for 4 h, filter to obtain the first extract and the first filter residue. Then add 25 g of Fructus Mume, 25 g of Rhizoma Acori Tatarinowii, and 1250 mL of 70% ethanol aqueous solution to the first filter residue, extract at 68 °C for 4 h, and filter to obtain the second extract and the second filter residue;

[0075] S7: Mix 15 mL of the first extract with 25 mL of the second extract to obtain a combined traditional Chinese medicine extract;

[0076] S8: Disperse 10 g of the antibacterial carrier in 30 g of glycerol, then grind to a D50 particle size of 200 nm to obtain a carrier dispersion;

[0077] S9: Add 5 g of aloe vera gel to 100 mL of deionized water and stir evenly to obtain an aloe dispersion;

[0078] S10: At 62°C, mix 14.4 g of cocamidopropyl betaine, 6 g of glyceryl laurate, and 0.24 g of disodium ethylenediaminetetraacetate and stir at 300 r / min for 20 min. Then add 72 mL of aloe vera dispersion and emulsify at 5000 r / min at 62°C for 15 min. After cooling to 45°C, add 7.2 g of carrier dispersion and stir at 400 r / min for 20 min. After cooling to 40°C, add 2.4 g of fragrance-retaining particles, 17.4 g of combined traditional Chinese medicine extract, and 0.36 g of rosmarinic acid and stir at 200 r / min for 20 min. Then adjust the pH to 6.0 with a 10% (mass fraction) citric acid solution, perform a homogenization treatment at 30°C and 20 MPa with a flow rate of 10 L / min and a circulation times of 2, and finally stand for defoaming for 60 min under a vacuum of -0.08 MPa. After filtering through a 0.22-μm filter membrane, an antibacterial and fragrance-retaining body wash is obtained.

[0079] Comparative Example 1:

[0080] Compared with Example 1, in this comparative example, only the "pretreatment zinc oxide" added in the preparation process of the modified zinc oxide in S2 is replaced with "nano zinc oxide", and the remaining steps and parameters are the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance-retaining body wash is obtained.

[0081] Comparative Example 2:

[0082] Compared with Example 1, in this comparative example, only the following in the preparation process of S6 is replaced: "After ultramicro-pulverizing 40 g of Coptis chinensis and 5 g of Fructus Cnidii and mixing them with 450 mL of deionized water, extracting at 50°C for 2 h, filtering to obtain the first extract and the first filter residue, then adding 15 g of Fructus Mume, 15 g of Acorus tatarinowii, and 375 mL of 60% (mass fraction) ethanol aqueous solution to the first filter residue, extracting at 63°C for 2 h, and filtering to obtain the second extract and the second filter residue" is replaced with "After ultramicro-pulverizing 40 g of Coptis chinensis and 5 g of Fructus Cnidii and mixing them with 15 g of Fructus Mume, 15 g of Acorus tatarinowii, and 450 mL of deionized water, extracting at 50°C for 2 h, filtering to obtain the first extract and the first filter residue, then adding 375 mL of 60% (mass fraction) ethanol aqueous solution to the first filter residue, extracting at 63°C for 2 h, and filtering to obtain the second extract and the second filter residue". The remaining steps and parameters are the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance-retaining body wash is obtained.

[0083] Comparative Example 3:

[0084] Compared with Example 1, in this comparative example, only the "aloe vera dispersion" added in the preparation process of the antibacterial and fragrance-retaining body wash in S10 is replaced with "deionized water", and the remaining steps and parameters are the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance-retaining body wash is obtained.

[0085] Comparative Example 4:

[0086] In this comparative example, compared with Example 1, only the "carrier dispersion liquid" added in the preparation process of the antibacterial and fragrance - retaining body wash of S10 was replaced with "glycerol", and the remaining steps and parameters were the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance - retaining body wash was obtained.

[0087] Comparative Example 5:

[0088] In this comparative example, compared with Example 1, only the "2 g fragrance - retaining microparticles" added in the preparation process of the antibacterial and fragrance - retaining body wash of S10 was replaced with "0.16 g vanillin", and the remaining steps and parameters were the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance - retaining body wash was obtained.

[0089] Comparative Example 6:

[0090] In this comparative example, compared with Example 1, only the "combined traditional Chinese medicine extract" added in the preparation process of the antibacterial and fragrance - retaining body wash of S10 was replaced with "deionized water", and the remaining steps and parameters were the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance - retaining body wash was obtained.

[0091] Comparative Example 7:

[0092] In this comparative example, compared with Example 1, only the "rosmarinic acid" added in the preparation process of the antibacterial and fragrance - retaining body wash of S10 was replaced with "fragrance - retaining microparticles", and the remaining steps and parameters were the same. This comparative example will not be repeated here, and finally an antibacterial and fragrance - retaining body wash was obtained.

[0093] Performance detection:

[0094] Determination of antibacterial property:

[0095] Escherichia coli (bacterium 1) and Staphylococcus aureus (bacterium 2) were respectively cultured in LB solid medium for 12 h at 37°C. When the strains grew to the exponential growth phase, the strains were diluted with sterile water to prepare a bacterial suspension with a concentration of 106 CFU / mL. The body wash was diluted with deionized water to a concentration of 20 wt%, and then a filter paper disc with a diameter of 5 mm and a thickness of 2.5 mm was immersed. After absorption was saturated, it was taken out to obtain an antibacterial sample disc. Each bacterial suspension (30 μL) was respectively inoculated on an agar solid medium plate and spread evenly, and then each antibacterial sample disc was placed on the medium. The plate was placed in a biochemical incubator at 37°C for 24 h, and an electronic vernier caliper was used to measure the diameter (mm) of the antibacterial zone of each antibacterial sample disc. According to this method, the antibacterial properties (mm) of the antibacterial and fragrance - retaining body washes prepared in Examples 1 - 3 and Comparative Examples 1 - 7 of the present invention were determined, and the test results are shown in Table 1 below.

[0096] Determination of fragrance - retaining ability:

[0097] One hundred subjects without skin diseases (50 males and 50 females, all aged between 20 and 45 years old, with the males having an average oily skin type and the females having a dry skin type) were divided into 10 groups randomly by gender (5 males and 5 females in each group). Then, each group was bathed with the antibacterial and fragrance-retaining body wash prepared in Examples 1 - 3 and Comparative Examples 1 - 7 of the present invention (the first group used the product prepared in Example 1, the second group used the product prepared in Example 2, and so on) (during this bathing test, the subjects did not take a bath or use other products within 72 hours before and after). The duration of the fragrance remaining on the skin surface of the subjects was recorded, and the average duration of the 10 subjects in each group was calculated as the measurement result of the fragrance-retaining ability (h) of the antibacterial and fragrance-retaining body wash of the present invention. The measurement results are shown in Table 1 below.

[0098] Determination of moisturizing ability:

[0099] One hundred subjects without skin diseases (50 males and 50 females, all aged between 20 and 45 years old, with the males having an average oily skin type and the females having a dry skin type) were divided into 10 groups randomly by gender (5 males and 5 females in each group). Then, each group was bathed with the antibacterial and fragrance-retaining body wash prepared in Examples 1 - 3 and Comparative Examples 1 - 7 of the present invention (the first group used the product prepared in Example 1, the second group used the product prepared in Example 2, and so on) (during this bathing test, the subjects did not take a bath or use other products within 72 hours before and after). The duration during which the skin surface of the subjects had no peeling, no itching, and the moisture content on the skin surface was not less than 30% was recorded, and the average duration of the 10 subjects in each group was calculated as the measurement result of the moisturizing ability (h) of the antibacterial and fragrance-retaining body wash of the present invention. The measurement results are shown in Table 1 below.

[0100] Determination of storage stability:

[0101] After the prepared antibacterial and fragrance-retaining body wash was bottled and sealed, it was stored at 30°C for 100 days. Then, according to the same method as above, the antibacterial property (%) and fragrance-retaining ability (h) of the antibacterial and fragrance-retaining body wash prepared in Examples 1 - 3 and Comparative Examples 1 - 7 of the present invention after storage were determined. The measurement results are shown in Table 1 below.

[0102] Table 1: Performance test results of Examples 1 - 3 and Comparative Examples 1 - 7

[0103]

[0104] Data analysis:

[0105] As can be seen from Table 1, the antibacterial and fragrance-retaining body wash prepared in the examples of the present invention has more excellent antibacterial property, fragrance-retaining ability, moisturizing ability, and storage stability.

[0106] This may be due to:

[0107] (1) The present invention coats a mesoporous silica layer on the surface of nano-zinc oxide by the sol-gel method, which improves the dispersibility of the antibacterial carrier and its compatibility with surfactants, and loads tea tree oil on the modified zinc oxide, enabling the slow release of tea tree oil and realizing the dual mechanisms of contact sterilization and antibacterial by the volatility of plant essential oils, greatly enhancing the antibacterial ability and antibacterial duration of the shower gel. Processes such as pretreatment effectively inhibit phenomena such as precipitation and stratification of zinc oxide, as well as the oxidation and volatilization of tea tree oil during storage, thereby improving the storage stability and texture uniformity of the shower gel. At the same time, the present invention disperses the antibacterial carrier that can form a protective film on the skin surface to reduce the loss of skin moisture in glycerol that can absorb moisture in the air, further improving the moisturizing and nourishing performance of the shower gel.

[0108] (2) During the preparation process of the fragrance-retaining particles of the present invention, ultrasonic-assisted inclusion technology is adopted to embed vanillin molecules into the cavity of cyclodextrin and crosslink them with polyethylene glycol diglycidyl ether to form a more stable three-dimensional network structure, realizing pH-responsive slow release (gradually releasing in water and accelerating release in the weakly acidic environment on the skin surface), effectively improving the stability of vanillin in the shower gel and ensuring the uniformity of the shower gel during storage and use. This also enables vanillin not to volatilize rapidly during the use of the shower gel, but to be slowly released over time, thereby prolonging the stability and durability of the fragrance on the skin surface after bathing. Moreover, the fragrance-retaining particles and components such as antibacterial carriers and combined traditional Chinese medicine extracts will produce a synergistic effect, making the smell of the shower gel fresher, more pleasant and layered, while also further improving the moisturizing, antibacterial, fragrance-retaining and storage stability of the shower gel.

[0109] (3) Coptis chinensis in the combined traditional Chinese medicine extract of the present invention has the effects of clearing heat and drying dampness, purging fire and detoxifying; Cnidium monnieri can dry dampness and expel wind, kill insects and relieve itching; Fructus Mume can astringe the lung and arrest diarrhea, promote the production of body fluid and arrest worms; Acorus tatarinowii can open orifices and resolve phlegm, restore consciousness and improve intelligence, promote digestion by removing dampness; and all of them have antibacterial effects and can also produce a synergistic effect. The present invention mixes them in a specific ratio and performs double and repeated extractions to maximize the inhibitory effect of the combined traditional Chinese medicine extract on harmful pathogens; at the same time, it can also improve the ability of the shower gel to relieve skin itching, inflammation and maintain the activity of beneficial bacteria on the skin surface.

[0110] (4) Rosmarinic acid in the present invention can synergistically inhibit bacteria and reduce inflammation with components such as the combined traditional Chinese medicine extract, expanding the antibacterial range, enhancing the overall antibacterial efficacy of the body wash and the anti-inflammatory and soothing effect on the skin. At the same time, it can also maintain the acid-base balance of the system, prevent other components from being inactivated or denatured due to oxidation, and prevent phenomena such as delamination and demulsification during storage and use of the emulsion, improving the antioxidant capacity and storage stability of the body wash, making the antibacterial performance and fragrance retention performance of the body wash more stable and lasting during use, and prolonging the effective antibacterial period of the product. Rosmarinic acid can also help the skin resist oxidative stress caused by the external environment, reduce oxidative damage to skin cells, and delay skin aging.

[0111] (5) While the aloe vera gel of the present invention reduces the irritation of the body wash, improves the moisturizing ability, soothing and skin repair ability of the body wash, it can also prevent delamination or precipitation of components such as cocamidopropyl betaine and glycerol laurate, bacteria carriers, and fragrance-retaining particles, thus ensuring the stability and uniformity of the body wash product. At the same time, for solid particle components such as inhibitors added subsequently, the aloe vera gel can also help them disperse evenly in the system, avoid aggregation, and enable the functional components to play a better role.

[0112] The above has described an embodiment of the present invention in detail, but the content described is only the preferred embodiment of the present invention and cannot be considered as limiting the scope of implementation of the present invention. All equivalent changes and improvements made according to the scope of the application of the present invention should still fall within the scope covered by the patent of the present invention.

Claims

1. A preparation method of an antibacterial and fragrance - retaining body wash, characterized in that, It includes the following steps: At 58 - 62 °C, cocamidopropyl betaine, glyceryl laurate, and disodium ethylenediaminetetraacetate are mixed evenly, then aloe dispersant is added and emulsified. After cooling to 40 - 45 °C, carrier dispersant is added and stirred evenly. After cooling to 30 - 40 °C, fragrance-retaining particles, combined traditional Chinese medicine extract, and rosmarinic acid are added and stirred evenly. Then the pH is adjusted to 5.5 - 6.0 with citric acid solution. Finally, after homogenization, static defoaming, and filtration, an antibacterial and fragrance-retaining body wash is obtained.

2. The preparation method of the antibacterial and fragrance - retaining body wash according to claim 1, wherein, The dosage ratio of cocamidopropyl betaine, glyceryl laurate, disodium ethylenediaminetetraacetate, aloe dispersant, carrier dispersant, fragrance-retaining particles, combined traditional Chinese medicine extract, and rosmarinic acid is 12 - 14.4 g : 5 - 6 g : 0.2 - 0.24 g : 60 - 72 mL : 6 - 7.2 g : 2 - 2.4 g : 14.5 - 17.4 g : 0.3 - 0.36 g; The rotation speed during the emulsification process is 4800 - 5000 r / min, and the duration is 10 - 15 min.

3. The preparation method of the antibacterial and fragrance-retaining body wash according to claim 1, wherein The preparation method of the carrier dispersant is as follows: Step A1: Ethanol and deionized water are mixed and nano-zinc oxide is added. After ultrasonic treatment, tetraethyl orthosilicate is added, and ammonia water is added dropwise with stirring at 48 - 50 °C. After reacting for 4 - 5 h, centrifugation is carried out, and finally, after washing and vacuum drying, pretreated zinc oxide is obtained; Step A2: The pretreated zinc oxide is dispersed in ethanol, then γ-aminopropyltriethoxysilane is added and refluxed at 70 - 75 °C for 6 - 7 h. After centrifugal separation and drying, modified zinc oxide is obtained; Step A3: Tea tree oil and ethanol are successively added to the modified zinc oxide, then ultrasonic-assisted reaction is carried out at 35 - 40 °C. After centrifugation and drying, an antibacterial carrier is obtained; Step A4: The antibacterial carrier is dispersed in glycerol and ground to obtain the carrier dispersant.

4. The preparation method of the antibacterial and fragrance - retaining body wash according to claim 3, wherein, The dosage ratio of ethanol, deionized water, nano-zinc oxide, tetraethyl orthosilicate, and ammonia water in Step A1 is 100 - 200 mL : 25 - 50 mL : 5 - 10 g : 4 - 8 mL : 2.5 - 5 mL; The mass fraction of ammonia water in Step A1 is 25% - 28%; The dosage ratio of the pretreated zinc oxide, ethanol, and γ-aminopropyltriethoxysilane in Step A2 is 5 - 10 g : 50 - 100 mL : 1 - 2 mL.

5. The preparation method of the antibacterial and fragrance - retaining body wash according to claim 3, wherein, The dosage ratio of the modified zinc oxide, tea tree oil, and ethanol in Step A3 is 5 - 10 g : 1 - 3 g : 25 - 50 mL; The ultrasonic power during the ultrasonic-assisted reaction in Step A3 is 180 - 200 W, the ultrasonic frequency is 35 - 40 kHz, and the reaction duration is 2 - 3 h; The dosage ratio of the antibacterial carrier and glycerol in Step A4 is 5 - 10 g : 15 - 30 g.

6. The preparation method of the antibacterial and fragrance - retaining body wash according to claim 1, wherein, The preparation method of the fragrance-retaining particles is as follows: Step B1: Vanillin is dissolved in ethanol to obtain a vanillin solution; Step B2: Dissolve β-cyclodextrin in deionized water at 55 - 60 °C, then add vanillin solution dropwise at 40 - 45 °C and perform ultrasonic treatment. After standing for 12 - 15 h, add polyethylene glycol diglycidyl ether. Adjust the pH to 8.8 - 9.2 and stir and react at 45 - 50 °C for 4 - 5 h. Then, perform freeze-drying, crushing, and sieving to obtain the fragrance-retaining microparticles.

7. The preparation method of the antibacterial and fragrance - retaining body wash according to claim 6, characterized in that, In step B1, the dosage ratio of vanillin to ethanol is 2 - 3 g : 8 - 12 g; In step B2, the dosage ratio of β-cyclodextrin, deionized water, vanillin solution, and polyethylene glycol diglycidyl ether is 10 - 15 g : 90 - 135 g : 8 - 12 g : 2 - 3 g.

8. The preparation method of the antibacterial and fragrance-retaining body wash according to claim 1, characterized in that The preparation method of the combined traditional Chinese medicine extract is as follows: Step C1: Ultrafinely pulverize Coptis chinensis Franch. and Fructus Cnidii, mix them with deionized water, extract at 50 - 70 °C for 2 - 4 h, filter to obtain the first extract and the first filter residue. Then, add Fructus Mume, Acorus tatarinowii Schott, and ethanol aqueous solution to the first filter residue, extract at 63 - 68 °C for 2 - 4 h, and filter to obtain the second extract and the second filter residue; Step C2: Mix the first extract and the second extract to obtain the combined traditional Chinese medicine extract.

9. The preparation method of the antibacterial and fragrance-retaining body wash according to claim 8, wherein, In step C1, the dosage ratio of Coptis chinensis Franch., Fructus Cnidii, deionized water, Fructus Mume, Acorus tatarinowii Schott, and ethanol aqueous solution is 40 - 60 g : 5 - 15 g : 450 - 750 mL : 15 - 25 g : 15 - 25 g : 375 - 1250 mL; In step C1, the mass fraction of the ethanol aqueous solution is 60% - 70%; In step C2, the dosage ratio of the first extract to the second extract is 9 - 15 mL : 7.5 - 25 mL.

10. The preparation method of the antibacterial and fragrance-retaining body wash according to claim 1, wherein, The preparation method of the aloe dispersant is as follows: Add 3 - 5 g of aloe vera gel to 60 - 100 mL of deionized water and stir evenly to obtain the aloe dispersant.

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