Antibacterial and breathable medical adhesive tape and preparation method thereof

Abstract

The application discloses an antibacterial and breathable medical adhesive tape and a preparation method thereof, and relates to the technical field of medical supplies.The medical adhesive tape comprises, from inside to outside, a hydrophobic antibacterial layer, an antibacterial intermediate layer, a liquid absorbing outer layer and a hydrophobic coating layer.The hydrophobic antibacterial layer is an Ag-PU / PAN nanofiber membrane.The antibacterial intermediate layer is an ALZ-PEO / CS nanofiber membrane.The liquid absorbing outer layer is a PAN nanofiber membrane.The hydrophobic coating layer is a HAR / TTMAP emulsion.The antibacterial and breathable medical adhesive tape provided by the application not only has excellent water resistance, antibacterial property and breathability, but also has a one-way wetness guiding function, and can effectively achieve the effect of sweat removal.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical supplies technology, in particular to an antibacterial and breathable medical adhesive tape and a preparation method thereof. BACKGROUND

[0002] Wound healing is a complex and easily influenced process, and in order to ensure the best wound healing management, the selection of medical adhesive tape is crucial. In terms of function, the core role of medical adhesive tape is to fix medical devices such as wound dressings and catheters, so as to prevent them from moving or falling off, thereby providing a continuous and stable protective barrier for the wound. In addition, some medical adhesive tapes also achieve the function of auxiliary treatment by adding drug ingredients, for example, silver ion-containing adhesive tapes can inhibit bacterial growth, and lidocaine-containing adhesive tapes have local analgesic effect. These functions make medical adhesive tapes play a key role in wound care, catheter fixation and postoperative recovery.

[0003] The current medical adhesive tape technology on the market presents diversified development, mainly including pressure-sensitive medical adhesive tape, moisture-proof and anti-allergic medical adhesive tape, paper anti-allergic medical adhesive tape and fully transparent and breathable medical adhesive tape and the like. The pressure-sensitive medical adhesive tape is characterized by strong adhesion, and is suitable for fixing catheters and dressings, but may cause allergic problems; the moisture-proof and anti-allergic medical adhesive tape uses non-woven fabric substrate and anti-allergic adhesive layer, aiming to reduce skin adverse reactions; the paper anti-allergic medical adhesive tape is suitable for patients with sensitive skin due to its softness and breathability, but its adhesion is relatively low.

[0004] However, due to the material and process limitations of traditional medical adhesive tapes, there is still a problem of poor breathability, and long-term application can easily cause local skin moisture and whitening, increasing the risk of infection. Even though some special adhesive tapes have improved breathability through material modification, there are still deficiencies in antibacterial performance. Therefore, it is urgent to develop a medical adhesive tape product with efficient antibacterial and excellent breathability, so as to improve the treatment comfort and prognosis of patients. SUMMARY

[0005] In order to improve the defects of the existing medical adhesive tape in terms of insufficient antibacterial and breathability, the present application provides an antibacterial and breathable medical adhesive tape and a preparation method thereof.

[0006] The antibacterial and breathable medical adhesive tape provided by the present application adopts the following technical scheme:

[0007] The medical adhesive tape comprises, from inside to outside, a hydrophobic antibacterial layer, an antibacterial intermediate layer, a liquid-absorbing outer layer and a hydrophobic coating layer; the hydrophobic antibacterial layer is an Ag-PU / PAN nanofiber membrane; the antibacterial intermediate layer is an ALZ-PEO / CS nanofiber membrane; the liquid-absorbing outer layer is a PAN nanofiber membrane; and the hydrophobic coating layer is a HAR / TTMAP emulsion.

[0008] The application also provides a preparation method of the antibacterial and breathable medical adhesive tape.

[0009] The preparation method of the antibacterial and breathable medical adhesive tape comprises the following steps:

[0010] S1. configuring Ag-PU / PAN spinning solution, injecting the Ag-PU / PAN spinning solution into a syringe, and then starting spinning; the spinning conditions are as follows: a spinning voltage of 16-18 KV, a liquid supply rate of 0.01-0.03 mL / min, a spinning distance of 16-20 cm, a receiving speed of the drum receiver of 300-400 rpm / min, and a spinning time of 5-7 h; and an Ag-PU / PAN nanofiber membrane is obtained;

[0011] S2. configuring ALZ-PEO / CS spinning solution, injecting the ALZ-PEO / CS spinning solution into a syringe, and then spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions are as follows: a spinning voltage of 10-14 KV, a liquid supply rate of 0.01-0.03 mL / min, a spinning distance of 13-15 cm, a receiving speed of the drum receiver of 300-400 rpm / min, and a spinning time of 3-5 h;

[0012] S3. configuring PAN spinning solution, injecting the PAN spinning solution into a syringe, and then spinning on the ALZ-PEO / CS nanofiber membrane with the double-layer fiber membrane as a receiving substrate; the spinning conditions are as follows: a spinning voltage of 10-14 KV, a liquid supply rate of 0.01-0.03 mL / min, a spinning distance of 13-15 cm, a receiving speed of the drum receiver of 300-400 rpm / min, and a spinning time of 3-5 h;

[0013] S4. spraying HAR / TTMAP emulsion of 1-3 mL / cm 2 on the PAN nanofiber membrane layer to obtain a composite nanofiber membrane; placing the composite nanofiber membrane in a dryer to crosslink in glutaraldehyde vapor for 10-16 h, and then placing the composite nanofiber membrane in a fume hood to be stored after residual glutaraldehyde volatilizes, thereby obtaining the antibacterial and breathable medical adhesive tape.

[0014] Preferably, the raw materials of the Ag-PU / PAN spinning solution comprise, by weight: 85-100 parts of N,N-dimethylformamide, 0.4-0.6 parts of silver nitrate, 3-5 parts of polyurethane powder, and 7-12 parts of polyacrylonitrile powder.

[0015] Preferably, the preparation method of the Ag-PU / PAN spinning solution comprises the following steps:

[0016] Silver nitrate is added into N,N-dimethylformamide, and stirred at room temperature for 1-3h to obtain a silver nitrate solution; polyurethane powder and polyacrylonitrile powder are added into the silver nitrate solution, and stirred at room temperature for 5-7h to obtain the Ag-PU / PAN spinning solution.

[0017] Preferably, the raw materials of the ALZ-PEO / CS spinning solution include, by weight fraction, 1.2-2.4 parts of polyethylene oxide powder, 2.8-5.6 parts of chitosan powder, and 95-115 parts of 70% acetic acid solution.

[0018] Preferably, the method for preparing the ALZ-PEO / CS spinning solution includes the following steps:

[0019] Polyethylene oxide powder and chitosan powder are added into 70% acetic acid solution, and stirred at room temperature for 5-7h to obtain the ALZ-PEO / CS spinning solution.

[0020] Preferably, the raw materials of the PAN spinning solution include, by weight fraction, 10-14 parts of polyacrylonitrile powder and 80-100 parts of N,N-dimethylformamide.

[0021] Preferably, the method for preparing the PAN spinning solution includes the following steps:

[0022] Polyacrylonitrile powder is added into N,N-dimethylformamide, and stirred to obtain the PAN spinning solution.

[0023] Preferably, the raw materials of the HAR / TTMAP emulsion include, by weight fraction, 4-12 parts of fluorine-free water-based hydroxyl acrylic resin, 0.04-0.12 parts of aziridine, and 88-96 parts of deionized water.

[0024] Preferably, the method for preparing the HAR / TTMAP emulsion includes the following steps:

[0025] The fluorine-free water-based hydroxyl acrylic resin is slowly added into deionized water, and stirred for 1-3h, then the aziridine is added, and stirred magnetically at room temperature for 30-90min to obtain the HAR / TTMAP emulsion.

[0026] In summary, the present application has at least one of the following beneficial technical effects:

[0027] 1. The present application uses Ag-PU / PAN nanofiber membrane as a hydrophobic antibacterial layer, ALZ-PEO / CS nanofiber membrane as an antibacterial intermediate layer, and PAN nanofiber membrane as a liquid-absorbing outer layer, which utilizes the difference in hydrophilicity of the three layers to endow the fiber membrane with good unidirectional wetting performance, air and moisture permeability, and antibacterial property.

[0028] 2.The application uses HAR / TTMAP emulsion as the hydrophobic coating of medical adhesive tape, uses fluorine-free water-based hydroxyl acrylic resin (HAR) with long hydrocarbon chain structure as the coating hydrophobic agent, and uniformly coats the PAN nanofiber membrane surface under the action of aziridine crosslinking agent (TTMAP), so that the outer surface of the medical adhesive tape has excellent waterproofness, and by controlling the coating amount of HAR / TTMAP emulsion, the medical adhesive tape has the function of blocking external moisture while not affecting the one-way wetting performance of the adhesive tape. DETAILED DESCRIPTION

[0029] The application will be further described in detail below in combination with examples.

[0030] The chemical reagents used in the preparation examples, examples and comparative examples provided by the application are all commercially available.

[0031] Example 1

[0032] S1. Configure Ag-PU / PAN spinning solution, add 0.4g silver nitrate to 85g N,N-dimethylformamide, seal and stir at room temperature for 1h to obtain a silver nitrate solution; add 3g polyurethane powder and 7g polyacrylonitrile powder to the silver nitrate solution, seal and stir at room temperature for 5h to obtain Ag-PU / PAN spinning solution; inject the Ag-PU / PAN spinning solution into a syringe and start spinning; spinning conditions: spinning voltage 16KV, liquid supply rate set to 0.01mL / min, spinning distance 16cm, receiving speed of drum receiver 300rpm / min, spinning time 5h; obtain Ag-PU / PAN nanofiber membrane;

[0033] S2. Configure ALZ-PEO / CS spinning solution, add 1.2g polyethylene oxide powder and 2.8g chitosan powder to 95g 70% mass fraction acetic acid solution, stir at room temperature for 5h to obtain ALZ-PEO / CS spinning solution; inject the ALZ-PEO / CS spinning solution into a syringe and spin on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; spinning conditions: spinning voltage 10KV, liquid supply rate set to 0.01mL / min, spinning distance 13cm, receiving speed of drum receiver 300rpm / min, spinning time 3h;

[0034] S3. The PAN spinning solution was configured by adding 10 g of polyacrylonitrile powder to 80 g of N, N-dimethylformamide, and stirring uniformly to obtain the PAN spinning solution; the PAN spinning solution was injected into a syringe, and the double-layer fiber membrane was used as the receiving substrate to perform spinning on the ALZ-PEO / CS nanofiber membrane; the spinning conditions were as follows: a spinning voltage of 10 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 13 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 3 h;

[0035] S4. 4 g of fluorine-free aqueous hydroxyl acrylic resin was slowly added to 96 g of deionized water, stirred for 1 h, and then 0.04 g of aziridine was added. After magnetic stirring at room temperature for 30 min, the HAR / TTMAP emulsion was obtained. The HAR / TTMAP emulsion was sprayed at a rate of 1 mL / cm 2 over the PAN nanofiber membrane layer to obtain a composite nanofiber membrane; the composite nanofiber membrane was placed in a dryer to crosslink in glutaraldehyde vapor for 10 h, and then placed in a fume hood to be stored after the residual glutaraldehyde volatilized, thereby obtaining an antibacterial and breathable medical adhesive tape.

[0036] Example 2

[0037] S1. The Ag-PU / PAN spinning solution was configured by adding 0.45 g of silver nitrate to 90 g of N, N-dimethylformamide, and stirring at room temperature in the dark for 1.5 h to obtain a silver nitrate solution; 3.5 g of polyurethane powder and 8 g of polyacrylonitrile powder were added to the silver nitrate solution, and stirred at room temperature for 5.5 h to obtain the Ag-PU / PAN spinning solution; the Ag-PU / PAN spinning solution was injected into a syringe to start spinning; the spinning conditions were as follows: a spinning voltage of 16 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 16 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 5 h; and the Ag-PU / PAN nanofiber membrane was obtained.

[0038] S2. The ALZ-PEO / CS spinning solution was configured by adding 1.5 g of polyethylene oxide powder and 3.5 g of chitosan powder to 100 g of 70% acetic acid solution, and stirring at room temperature for 5.5 h to obtain the ALZ-PEO / CS spinning solution; the ALZ-PEO / CS spinning solution was injected into a syringe to perform spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions were as follows: a spinning voltage of 10 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 13 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 3 h;

[0039] S3. The PAN spinning solution was configured by adding 11 g of polyacrylonitrile powder to 85 g of N, N-dimethylformamide, and stirring uniformly to obtain the PAN spinning solution; the PAN spinning solution was injected into a syringe, and the double-layer fiber membrane was used as the receiving substrate to perform spinning on the ALZ-PEO / CS nanofiber membrane; the spinning conditions were as follows: a spinning voltage of 10 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 13 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 3 h;

[0040] S4. 6 g of fluorine-free aqueous hydroxyl acrylic resin was slowly added to 94 g of deionized water, stirred for 1.5 h, and then 0.06 g of aziridine was added. After magnetic stirring at room temperature for 45 min, the HAR / TTMAP emulsion was obtained. The HAR / TTMAP emulsion was sprayed on the PAN nanofiber membrane layer at a rate of 1.5 mL / cm 2 to obtain the composite nanofiber membrane; the composite nanofiber membrane was placed in a dryer to crosslink in glutaraldehyde vapor for 11.5 h, and then placed in a fume hood to be stored after the residual glutaraldehyde volatilized, to obtain the antibacterial and breathable medical adhesive tape.

[0041] Example 3

[0042] S1. The Ag-PU / PAN spinning solution was configured by adding 0.5 g of silver nitrate to 90 g of N, N-dimethylformamide, and stirring at room temperature in the dark for 2 h to obtain a silver nitrate solution; 4 g of polyurethane powder and 9.5 g of polyacrylonitrile powder were added to the silver nitrate solution, and stirred at room temperature for 6 h to obtain the Ag-PU / PAN spinning solution; the Ag-PU / PAN spinning solution was injected into a syringe to start spinning; the spinning conditions were as follows: a spinning voltage of 14 KV, a liquid supply rate of 0.02 mL / min, a spinning distance of 18 cm, a receiving speed of the drum receiver of 350 rpm / min, and a spinning time of 6 h; the Ag-PU / PAN nanofiber membrane was obtained;

[0043] S2. The ALZ-PEO / CS spinning solution was configured by adding 1.8 g of polyethylene oxide powder and 4.2 g of chitosan powder to 105 g of 70% acetic acid solution, and stirring at room temperature for 6 h to obtain the ALZ-PEO / CS spinning solution; the ALZ-PEO / CS spinning solution was injected into a syringe to perform spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions were as follows: a spinning voltage of 12 KV, a liquid supply rate of 0.02 mL / min, a spinning distance of 14 cm, a receiving speed of the drum receiver of 350 rpm / min, and a spinning time of 4 h;

[0044] S3. The PAN spinning solution was configured by adding 12 g of polyacrylonitrile powder to 90 g of N, N-dimethylformamide, and stirring uniformly to obtain the PAN spinning solution; the PAN spinning solution was injected into a syringe, and the double-layer fiber membrane was used as the receiving substrate to perform spinning on the ALZ-PEO / CS nanofiber membrane; the spinning conditions were as follows: a spinning voltage of 12 KV, a liquid supply rate of 0.02 mL / min, a spinning distance of 14 cm, a receiving speed of the drum receiver of 350 rpm / min, and a spinning time of 4 h;

[0045] S4. 8 g of fluorine-free aqueous hydroxyl acrylic resin was slowly added to 92 g of deionized water, stirred for 2 h, and then 0.08 g of aziridine was added, and the mixture was magnetically stirred at room temperature for 60 min to obtain the HAR / TTMAP emulsion; the HAR / TTMAP emulsion was sprayed at a rate of 2 mL / cm 2 to coat the PAN nanofiber membrane layer, to obtain a composite nanofiber membrane; the composite nanofiber membrane was placed in a dryer to crosslink in glutaraldehyde vapor for 13 h, and then placed in a fume hood to be stored after the residual glutaraldehyde volatilized, to obtain an antibacterial and breathable medical adhesive tape.

[0046] Example 4

[0047] S1. The Ag-PU / PAN spinning solution was configured by adding 0.55 g of silver nitrate to 95 g of N, N-dimethylformamide, stirring at room temperature in the dark for 2.5 h to obtain a silver nitrate solution; 4.5 g of polyurethane powder and 7 g of polyacrylonitrile powder were added to the silver nitrate solution, and the mixture was stirred at room temperature for 6.5 h to obtain the Ag-PU / PAN spinning solution; the Ag-PU / PAN spinning solution was injected into a syringe to start spinning; the spinning conditions were as follows: a spinning voltage of 18 KV, a liquid supply rate of 0.03 mL / min, a spinning distance of 20 cm, a receiving speed of the drum receiver of 400 rpm / min, and a spinning time of 7 h; and an Ag-PU / PAN nanofiber membrane was obtained.

[0048] S2. The ALZ-PEO / CS spinning solution was configured by adding 2.1 g of polyethylene oxide powder and 4.9 g of chitosan powder to 110 g of 70% acetic acid solution, and stirring at room temperature for 6.5 h to obtain the ALZ-PEO / CS spinning solution; the ALZ-PEO / CS spinning solution was injected into a syringe to perform spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions were as follows: a spinning voltage of 14 KV, a liquid supply rate of 0.03 mL / min, a spinning distance of 15 cm, a receiving speed of the drum receiver of 400 rpm / min, and a spinning time of 5 h;

[0049] S3. Configuration of PAN spinning solution, 13 g of polyacrylonitrile powder is added to 95 g of N, N-dimethylformamide, and after stirring evenly, the PAN spinning solution is obtained; the PAN spinning solution is injected into the syringe, and the double-layer fiber membrane is used as the receiving substrate to perform spinning on the ALZ-PEO / CS nanofiber membrane; the spinning conditions are as follows: the spinning voltage is 14 KV, the liquid supply rate is set to 0.03 mL / min, the spinning distance is 15 cm, the receiving speed of the drum receiver is 400 rpm / min, and the spinning time is 5 h;

[0050] S4. 10 g of fluorine-free water-based hydroxy acrylic resin is slowly added to 90 g of deionized water, stirred for 2.5 h, and then 0.1 g of aziridine is added. After magnetic stirring at room temperature for 75 min, the HAR / TTMAP emulsion is obtained. The HAR / TTMAP emulsion is sprayed on the PAN nanofiber membrane layer at a rate of 2.5 mL / cm 2 to obtain a composite nanofiber membrane; the composite nanofiber membrane is placed in a dryer to crosslink in glutaraldehyde vapor for 15 h, and then placed in a fume hood to be stored after the residual glutaraldehyde volatilizes, to obtain an antibacterial and breathable medical adhesive tape.

[0051] Example 5

[0052] S1. Configuration of Ag-PU / PAN spinning solution, 0.6 g of silver nitrate is added to 100 g of N, N-dimethylformamide, and stirred at room temperature in the dark for 3 h to obtain a silver nitrate solution; 5 g of polyurethane powder and 12 g of polyacrylonitrile powder are added to the silver nitrate solution, and stirred at room temperature for 7 h to obtain the Ag-PU / PAN spinning solution; the Ag-PU / PAN spinning solution is injected into the syringe to start spinning; the spinning conditions are as follows: the spinning voltage is 18 KV, the liquid supply rate is set to 0.03 mL / min, the spinning distance is 20 cm, the receiving speed of the drum receiver is 400 rpm / min, and the spinning time is 7 h; the Ag-PU / PAN nanofiber membrane is obtained;

[0053] S2. Configuration of ALZ-PEO / CS spinning solution, 2.4 g of polyethylene oxide powder and 5.6 g of chitosan powder are added to 115 g of 70% acetic acid solution, and stirred at room temperature for 7 h to obtain the ALZ-PEO / CS spinning solution; the ALZ-PEO / CS spinning solution is injected into the syringe to perform spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions are as follows: the spinning voltage is 14 KV, the liquid supply rate is set to 0.03 mL / min, the spinning distance is 15 cm, the receiving speed of the drum receiver is 400 rpm / min, and the spinning time is 5 h;

[0054] S3. The PAN spinning solution was configured by adding 14 g of polyacrylonitrile powder to 100 g of N, N-dimethylformamide, and stirring uniformly to obtain the PAN spinning solution; the PAN spinning solution was injected into a syringe, and the double-layer fiber membrane was used as the receiving substrate to perform spinning on the ALZ-PEO / CS nanofiber membrane; the spinning conditions were as follows: a spinning voltage of 14 KV, a liquid supply rate of 0.03 mL / min, a spinning distance of 15 cm, a receiving speed of the drum receiver of 400 rpm / min, and a spinning time of 5 h;

[0055] S4. 12 g of fluorine-free aqueous hydroxyl acrylic resin was slowly added to 88 g of deionized water, stirred for 3 h, and then 0.12 g of aziridine was added. After magnetic stirring at room temperature for 90 min, the HAR / TTMAP emulsion was obtained. The HAR / TTMAP emulsion was sprayed on the PAN nanofiber membrane layer at a rate of 3 mL / cm 2 to obtain a composite nanofiber membrane; the composite nanofiber membrane was placed in a dryer to crosslink in glutaraldehyde vapor for 16 h, and then placed in a fume hood to be stored after the residual glutaraldehyde was volatilized, thereby obtaining an antibacterial and breathable medical adhesive tape.

[0056] Comparative Example 1

[0057] Comparative Example 1 and Example 1 differ in that no HAR / TTMAP emulsion was sprayed in Comparative Example 1; the specific preparation method is as follows:

[0058] S1. The Ag-PU / PAN spinning solution was configured by adding 0.4 g of silver nitrate to 85 g of N, N-dimethylformamide, and stirring at room temperature in the dark for 1 h to obtain a silver nitrate solution; 3 g of polyurethane powder and 7 g of polyacrylonitrile powder were added to the silver nitrate solution, and the mixture was stirred at room temperature for 5 h to obtain the Ag-PU / PAN spinning solution; the Ag-PU / PAN spinning solution was injected into a syringe to start spinning; the spinning conditions were as follows: a spinning voltage of 16 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 16 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 5 h; and the Ag-PU / PAN nanofiber membrane was obtained.

[0059] S2. The ALZ-PEO / CS spinning solution was configured by adding 1.2 g of polyethylene oxide powder and 2.8 g of chitosan powder to 95 g of 70% acetic acid solution, and stirring at room temperature for 5 h to obtain the ALZ-PEO / CS spinning solution; the ALZ-PEO / CS spinning solution was injected into a syringe to perform spinning on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions were as follows: a spinning voltage of 10 KV, a liquid supply rate of 0.01 mL / min, a spinning distance of 13 cm, a receiving speed of the drum receiver of 300 rpm / min, and a spinning time of 3 h;

[0060] S3. Configuration of PAN spinning solution, 10 g of polyacrylonitrile powder is added to 80 g of N, N-dimethylformamide, and after stirring evenly, the PAN spinning solution is obtained; the PAN spinning solution is injected into a syringe, and spinning is carried out on the ALZ-PEO / CS nanofiber membrane with the double-layer fiber membrane as the receiving substrate; the spinning conditions are as follows: spinning voltage 10 KV, liquid supply rate 0.01 mL / min, spinning distance 13 cm, receiving speed of the drum receiver 300 rpm / min, and spinning time 3 h; the composite nanofiber membrane is obtained; the composite nanofiber membrane is placed in a dryer for crosslinking in glutaraldehyde vapor for 10 h, and after crosslinking is completed, it is placed in a fume hood for storage after residual glutaraldehyde is volatilized, and an antibacterial and breathable medical adhesive tape is obtained.

[0061] Comparative Example 2

[0062] Comparative Example 2 is different from Example 1 in that no Ag-PU / PAN nanofiber membrane is provided in Comparative Example 2; the specific preparation method is as follows:

[0063] S1. Configuration of Ag-PU / PAN spinning solution, 0.4 g of silver nitrate is added to 85 g of N, N-dimethylformamide, and after stirring at room temperature in the dark for 1 h, a silver nitrate solution is obtained; 3 g of polyurethane powder and 7 g of polyacrylonitrile powder are added to the silver nitrate solution, and after stirring at room temperature for 5 h, the Ag-PU / PAN spinning solution is obtained; the Ag-PU / PAN spinning solution is injected into a syringe, and spinning is started; the spinning conditions are as follows: spinning voltage 16 KV, liquid supply rate 0.01 mL / min, spinning distance 16 cm, receiving speed of the drum receiver 300 rpm / min, and spinning time 5 h; the Ag-PU / PAN nanofiber membrane is obtained;

[0064] S2. Configuration of ALZ-PEO / CS spinning solution, 1.2 g of polyethylene oxide powder and 2.8 g of chitosan powder are added to 95 g of 70% mass fraction acetic acid solution, and after stirring at room temperature for 5 h, the ALZ-PEO / CS spinning solution is obtained; the ALZ-PEO / CS spinning solution is injected into a syringe, and spinning is carried out on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; the spinning conditions are as follows: spinning voltage 10 KV, liquid supply rate 0.01 mL / min, spinning distance 13 cm, receiving speed of the drum receiver 300 rpm / min, and spinning time 3 h;

[0065] S3. 4 g of fluorine-free water-based hydroxy acrylate resin is slowly added to 96 g of deionized water, and after stirring for 1 h, 0.04 g of aziridine is added; after magnetic stirring at room temperature for 30 min, the HAR / TTMAP emulsion is obtained; the HAR / TTMAP emulsion is applied to the double-layer fiber membrane at a rate of 1 mL / cm 2Spraying above the PAN nanofiber membrane layer to obtain a composite nanofiber membrane; the composite nanofiber membrane is placed in a dryer to crosslink in glutaraldehyde vapor for 10 h, and after crosslinking is completed, it is placed in a fume hood to be stored after residual glutaraldehyde volatilizes, to obtain the antibacterial and breathable medical adhesive tape.

[0066] Performance detection test

[0067] I. Contact angle test: the dynamic contact angles of the outer layer and the inner layer of the antibacterial and breathable medical adhesive tape obtained in Examples 1-5 and Comparative Examples 1-2 were tested by using a contact angle tester, the sample was laid on the measuring table, 3 μL of water droplets were dropped on the surface of the outer layer and the inner layer of the antibacterial and breathable medical adhesive tape, and the contact angle of the water droplets after contacting the fiber membrane was recorded by using the video function of a high-speed camera, and the results are shown in Table 1.

[0068] Table 1 Contact angle test results

[0069]

[0070] It can be seen from the detection results in Table 1 that the outer layer and the inner layer of the antibacterial and breathable medical adhesive tape provided by the application both have excellent hydrophobicity.

[0071] II. Air permeability test: the air permeability of the antibacterial and breathable medical adhesive tape obtained in Examples 1-5 and Comparative Examples 1-2 was detected by using a YG461E digital air permeability meter. The pressure difference of the sample was set to 100 pa, the area of the sample to be tested was 25 cm 2 , 3 points on the sample were randomly selected for testing, and the final results were averaged for statistical analysis, and the results are shown in Table 2.

[0072] Table 2 Air permeability test results

[0073]

[0074] It can be seen from the detection results in Table 2 that the air permeability of the antibacterial and breathable medical adhesive tape provided by the application reaches 40 mm / s or more, indicating that the medical adhesive tape provided by the application has excellent air permeability.

[0075] III. Antimicrobial test: the antibacterial effect test of Staphylococcus aureus, Candida albicans, and Escherichia coli on the antibacterial and breathable medical adhesive tape obtained in Examples 1-5 and Comparative Examples 1-2 was carried out, and the results are shown in Table 3.

[0076] Table 2 Antimicrobial test results

[0077]

[0078] It can be seen from the detection results in Table 3 that the antibacterial and breathable medical adhesive tape provided by the application has strong antibacterial performance.

[0079] The embodiments are only illustrative of the present application, and are not intended to limit the present application. Those skilled in the art can make modifications to the embodiments according to the needs without creative contribution, as long as the modifications are within the scope of the claims of the present application.

Claims

1. A method for preparing antibacterial and breathable medical adhesive tape, characterized in that: The medical adhesive tape comprises, from the inside out, a hydrophobic antibacterial layer, an antibacterial intermediate layer, an absorbent outer layer, and a hydrophobic coating layer; the hydrophobic antibacterial layer is an Ag-PU / PAN nanofiber membrane; the antibacterial intermediate layer is an ALZ-PEO / CS nanofiber membrane; the absorbent outer layer is a PAN nanofiber membrane; and the hydrophobic coating layer is a HAR / TTMAP emulsion. The preparation method of the antibacterial and breathable medical adhesive tape includes the following steps: S1. Prepare Ag-PU / PAN spinning solution. Inject the Ag-PU / PAN spinning solution into the syringe and start spinning. Spinning conditions: spinning voltage 16-18KV, liquid supply rate set to 0.01-0.03mL / min, spinning distance 16-20cm, receiving speed of the roller receiver 300-400rpm / min, spinning time 5-7h; obtain Ag-PU / PAN nanofiber membrane. S2. Prepare the ALZ-PEO / CS spinning solution, inject the ALZ-PEO / CS spinning solution into a syringe, and spin it on the Ag-PU / PAN nanofiber membrane to obtain a double-layer fiber membrane; spinning conditions: spinning voltage 10-14KV, liquid supply rate set to 0.01-0.03mL / min, spinning distance 13-15cm, receiving speed of the roller receiver 300-400rpm / min, spinning time 3-5h; S3. Prepare the PAN spinning solution and inject it into a syringe. Using the bilayer fiber membrane as the receiving substrate, spin on the ALZ-PEO / CS nanofiber membrane. Spinning conditions: spinning voltage 10-14KV, liquid supply rate set to 0.01-0.03mL / min, spinning distance 13-15cm, receiving speed of the roller receiver 300-400rpm / min, spinning time 3-5h. S4. Add HAR / TTMAP emulsion at a rate of 1-3 mL / cm³ 2 Spraying the PAN nanofiber membrane layer onto the composite nanofiber membrane layer yields a composite nanofiber membrane. The composite nanofiber membrane is placed in a desiccator and crosslinked in glutaraldehyde vapor for 10-16 hours. After crosslinking is completed, it is placed in a fume hood and stored after the residual glutaraldehyde has evaporated, thus obtaining an antibacterial and breathable medical adhesive tape. The raw materials of the Ag-PU / PAN spinning solution include, by weight: 85-100 parts N,N-dimethylformamide, 0.4-0.6 parts silver nitrate, 3-5 parts polyurethane powder, and 7-12 parts polyacrylonitrile powder. The raw materials of the ALZ-PEO / CS spinning solution include, by weight, 1.2-2.4 parts polyethylene oxide powder, 2.8-5.6 parts chitosan powder, and 95-115 parts acetic acid solution with a mass fraction of 70%. The raw materials of the PAN spinning solution include, by weight: 10-14 parts polyacrylonitrile powder and 80-100 parts N,N-dimethylformamide; The raw materials of the HAR / TTMAP emulsion include, by weight: 4-12 parts of fluorine-free waterborne hydroxyl acrylic resin, 0.04-0.12 parts of aziridine, and 88-96 parts of deionized water.

2. The method for preparing the antibacterial and breathable medical adhesive tape according to claim 1, characterized in that: The preparation method of the Ag-PU / PAN spinning solution includes the following steps: Silver nitrate was added to N,N-dimethylformamide and stirred in a sealed container at room temperature in the dark for 1-3 hours to obtain a silver nitrate solution. Polyurethane powder and polyacrylonitrile powder were added to the silver nitrate solution and stirred in a sealed container at room temperature for 5-7 hours to obtain the Ag-PU / PAN spinning solution.

3. The method for preparing the antibacterial and breathable medical adhesive tape according to claim 1, characterized in that: The preparation method of the ALZ-PEO / CS spinning solution includes the following steps: Polyoxyethylene powder and chitosan powder were added to a 70% (w / w) acetic acid solution and stirred at room temperature for 5-7 hours to obtain ALZ-PEO / CS spinning solution.

4. The method for preparing the antibacterial and breathable medical adhesive tape according to claim 1, characterized in that: The method for preparing the PAN spinning solution includes the following steps: Polyacrylonitrile powder is added to N,N-dimethylformamide and stirred until homogeneous to obtain PAN spinning solution.

5. The method for preparing the antibacterial and breathable medical adhesive tape according to claim 1, characterized in that: The method for preparing the HAR / TTMAP emulsion includes the following steps: The fluorine-free waterborne hydroxyl acrylic resin was slowly added to deionized water and stirred for 1-3 hours. Then, aziridine was added and the mixture was magnetically stirred at room temperature for 30-90 minutes to obtain the HAR / TTMAP emulsion.

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