Filtering and purifying equipment applied to biopharmaceutical production

Abstract

The invention belongs to the technical field of biopharmacy, and particularly relates to filtering and purifying equipment applied to biopharmacy production, the filtering and purifying equipment applied to biopharmacy production comprises a box body, a discharging pipeline is arranged on the lower right portion of the box body, and a pipeline valve is arranged on the outer surface of the discharging pipeline; a feeding hopper is arranged at the top of the box body, a connecting bearing located on the outer side of the feeding hopper is fixedly connected to the inner wall of the top of the box body, and a primary filtering cage located under the feeding hopper is fixedly connected to the inner surface of the connecting bearing. According to the filtering and purifying equipment applied to biopharmaceutical production, a stepping motor is started to control a rotating rod to rotate, the rotating rod rotates to enable a force application cam to intermittently apply force to a stressed circular truncated cone, and the stressed circular truncated cone is intermittently stressed to enable a secondary filter screen to reciprocate in the left-right direction under the action of a reset spring; furthermore, the effect of improving the filtering and purifying efficiency and precision is achieved through rapid reciprocating motion.

Description

Technical Field

[0001] The present invention belongs to the technical field of biopharmaceuticals, and specifically relates to a filtration and purification device applied to biopharmaceutical production. Background Art

[0002] Biopharmaceuticals, also known as biopharmaceutical products or biologics, refer to any pharmaceutical product manufactured, extracted or semi-synthesized from biological sources. Different from fully synthetic drugs, they include vaccines, whole blood, blood components, allergens, somatic cells, gene therapy, tissues, recombinant therapeutic proteins and living drugs for cell therapy. Biologics can be composed of sugars, proteins, nucleic acids or complex combinations of these substances, or can be living cells or tissues. They (or their precursors or components) are isolated from living sources - humans, animals, plants, fungi or microorganisms, and they can be used in human and veterinary medicine.

[0003] With the rapid development of the biopharmaceutical field, the requirements for biopharmaceutical production equipment have also increased. However, the existing filtration and purification equipment for biopharmaceutical production has low filtration efficiency and low precision of filtration and purification, which greatly affects the normal working efficiency. Summary of the Invention

[0004] The purpose of the present invention is to provide a filtration and purification device applied to biopharmaceutical production, which can complete the filtration and purification work with high efficiency and high precision.

[0005] The technical solution adopted by the present invention is specifically as follows: A filtering and purification device used in biopharmaceutical production, comprising a box body, a discharge pipe is arranged at the lower right side of the box body, a pipe valve is arranged on the outer surface of the discharge pipe, a feed hopper is arranged on the top of the box body, a connecting bearing located outside the feed hopper is fixedly connected to the inner wall of the top of the box body, a primary filter cage located directly below the feed hopper is fixedly connected to the inner surface of the connecting bearing, a feed port is opened at the top of the primary filter cage, a primary filter screen is arranged on the outer surface of the primary filter cage, a driving motor located below the primary filter cage is fixedly connected to the inner surface of the box body through a fixing rod, a rotating shaft is fixedly connected to the output end at the top of the driving motor, and the top end of the rotating shaft is fixedly connected to the center of the lower surface of the primary filter cage A mounting ring is fixedly connected to the inner wall of the box body, a secondary filter screen is fixedly connected to the inner surface of the mounting ring through a return spring, a vibration motor is fixedly connected to the bottom of the secondary filter screen, a force-bearing round table located on the left side of the vibration motor is fixedly connected to the inner wall on the left side of the box body, a stepper motor located below the mounting ring is fixedly connected to the inner wall on the left side of the box body, a rotating rod is fixedly connected to the output end on the right side of the stepper motor, a force-applying cam located on the front of the force-bearing round table is fixedly connected to the right end of the rotating rod, a rotating rod located below the stepper motor is rotatably connected to the inner wall on the left side of the box body through a combined bearing, a spiral push plate is fixedly connected to the outer surface of the rotating rod, and the outer surface of the rotating rod is transmission-connected to the rotating rod through a transmission belt.

[0006] In a preferred solution, a deflector located above the drive motor is fixedly connected to the outer surface of the rotating shaft.

[0007] In a preferred embodiment, guide grooves are provided on the inner wall of the back side of the box body and are located on both sides of the secondary filter screen. The top and bottom of the secondary filter screen are slidably connected to the inner surface of the guide grooves through guide rods.

[0008] In a preferred solution, two limit plates located on both sides of the transmission belt are fixedly connected to the outer surfaces of the rotating rod and the rotary rod.

[0009] In a preferred embodiment, guide grooves are provided on the inner surface of the feed hopper, the number of the guide grooves is not less than twelve, and not less than twelve of the guide grooves are arranged in a circular array.

[0010] In a preferred embodiment, an annular mounting groove located outside the feed hopper is opened inside the top wall of the box body, the outer surface of the feed hopper is slidably connected to the inner surface of the annular mounting groove via a positioning ring, a transmission ring is fixedly connected to the outer surface of the feed hopper, the top of the box body is fixedly connected to a synchronous motor via two support rods, a traction rod is fixedly connected to the output end of the bottom of the synchronous motor, and the outer surface of the traction rod is transmission-connected to the transmission ring via a traction belt.

[0011] In a preferred embodiment, stabilizing rods are fixedly connected to both sides of the primary filter cage, and stabilizing rollers are fixedly connected to the ends of the stabilizing rods away from the primary filter cage.

[0012] In a preferred embodiment, the number of the stabilizing rods and the stabilizing rollers is not less than six and they are arranged in a rectangular array.

[0013] In a preferred embodiment, the outer surface of the flow guide cover is a curved surface, and a lubricating pad is arranged on the outer surface of the flow guide cover.

[0014] In a preferred embodiment, wear-resistant pads are arranged on the inner surface of the guide groove and the outer surface of the guide rod.

[0015] The technical effects achieved by the present invention are as follows: By arranging a flow guide groove in the feed hopper, the present invention effectively avoids the situation of feed blockage, effectively improves the feed efficiency. By setting a synchronous motor to control the rotation of the feed hopper, it effectively makes the feed rotate and enter, and then the feed will be dispersed due to rotation, thereby effectively dispersing the feed and improving the filtration efficiency and quality.

[0016] By controlling the rotation of the primary filter cage with a drive motor, the present invention effectively performs primary filtration and purification on the feed. Then the feed after primary filtration and purification falls on the upper surface of the secondary filter screen. Starting the stepping motor to control the rotation of the rotating rod, the rotation of the rotating rod causes the force-applying cam to intermittently apply force to the force-receiving round table. The intermittent force on the force-receiving round table causes the secondary filter screen to perform reciprocating motion in the left-right direction under the action of the return spring. Then, through the rapid reciprocating motion, the filtration and purification efficiency and accuracy are improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of the internal structure of the front view of the present invention; Figure 2 is Figure 1 the enlarged view of part A in Figure 3 is a schematic diagram of the top view structure of the feed hopper of the present invention; Figure 4 is Figure 1 the enlarged view of part B in Figure 5 is a schematic diagram of the right view structure of the force-receiving round table of the present invention.

[0018] In the drawings, the list of components represented by each reference numeral is as follows: 1. Box body; 2. Discharge pipeline; 3. Pipeline valve; 4. Feed hopper; 5. Connecting bearing; 6. Primary filter cage; 7. Feed inlet; 8. Primary filter screen; 9. Fixed rod; 10. Driving motor; 11. Rotating shaft; 12. Deflector; 13. Mounting ring; 14. Return spring; 15. Secondary filter screen; 16. Guide groove; 17. Guide rod; 18. Vibration motor; 19. Force-receiving round table; 20. Stepper motor; 21. Rotating rod; 22. Force-applying cam; 23. Combined bearing; 24. Rotating rod; 25. Spiral pushing plate; 26. Transmission belt; 27. Limiting disc; 28. Flow guide groove; 29. Annular mounting groove; 30. Positioning ring; 31. Transmission ring; 32. Support rod; 33. Synchronous motor; 34. Towing rod; 35. Towing belt; 36. Stabilizing rod; 37. Stabilizing roller. Detailed implementation manners

[0019] In order to make the above objects, features and advantages of the present invention more obvious and understandable, the following will describe the detailed implementation manners of the present invention with reference to the accompanying drawings of the specification.

[0020] In the following description, many specific details are set forth in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described herein. Those skilled in the art can make similar promotions without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.

[0021] Secondly, the so-called "one embodiment" or "embodiment" herein refers to a specific feature, structure or characteristic that can be included in at least one implementation manner of the present invention. The phrase "in a preferred implementation manner" that appears in different places in this specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment that excludes other embodiments.

[0022] Furthermore, the present invention is described in detail with reference to the schematic diagrams. When describing the embodiments of the present invention in detail, for the convenience of explanation, the cross-sectional views showing the device structure will be enlarged locally out of the general proportion, and the schematic diagrams are only examples and should not limit the scope of protection of the present invention herein. In addition, in actual production, three-dimensional spatial dimensions including length, width and depth should be included.

[0023] Please refer to the attached Figures 1-5As shown, the present invention provides a filtering and purification device for biopharmaceutical production, including a box body 1, a discharge pipe 2 is arranged at the lower right side of the box body 1, a pipe valve 3 is arranged on the outer surface of the discharge pipe 2, a feed hopper 4 is arranged on the top of the box body 1, a connecting bearing 5 located outside the feed hopper 4 is fixedly connected to the inner wall of the top of the box body 1, a primary filter cage 6 located directly below the feed hopper 4 is fixedly connected to the inner surface of the connecting bearing 5, a feed port 7 is opened at the top of the primary filter cage 6, a primary filter screen 8 is arranged on the outer surface of the primary filter cage 6, a driving motor 10 located below the primary filter cage 6 is fixedly connected to the inner surface of the box body 1 through a fixing rod 9, a rotating shaft 11 is fixedly connected to the output end at the top of the driving motor 10, and the top of the rotating shaft 11 A guide hood 12 located above the drive motor 10 is fixedly connected to the center of the lower surface of the primary filter cage 6, and a guide hood 12 is fixedly connected to the outer surface of the rotating shaft 11. The outer surface of the guide hood 12 is a curved surface, and a sliding pad is arranged on the outer surface of the guide hood 12. A mounting ring 13 is fixedly connected to the inner wall of the box body 1, and a secondary filter screen 15 is fixedly connected to the inner surface of the mounting ring 13 through a reset spring 14. A guide groove 16 located on both sides of the secondary filter screen 15 is provided on the inner wall of the back side of the box body 1. The top and bottom of the secondary filter screen 15 are slidably connected to the inner surface of the guide groove 16 through a guide rod 17. Wear-resistant pads are arranged on the inner surface of the guide groove 16 and the outer surface of the guide rod 17. A vibration motor 18 is fixedly connected to the bottom of the secondary filter screen 15. The bottom of the net 15 is fixedly connected with a force-bearing truncated table 19 located on the left side of the vibration motor 18, and the inner wall on the left side of the box body 1 is fixedly connected with a stepper motor 20 located below the mounting ring 13, and the output end on the right side of the stepper motor 20 is fixedly connected with a rotating rod 21, and the right end of the rotating rod 21 is fixedly connected with a force-applying cam 22 located on the front side of the force-bearing truncated table 19. The inner wall on the left side of the box body 1 is rotatably connected with a rotating rod 24 located below the stepper motor 20 through a bearing 23, and a spiral push plate 25 is fixedly connected to the outer surface of the rotating rod 24, and the outer surface of the rotating rod 24 is transmission-connected to the rotating rod 21 through a transmission belt 26, and two limit plates 27 located on both sides of the transmission belt 26 are fixedly connected to the outer surfaces of the rotating rod 21 and the rotating rod 24, and the inner surface of the feed hopper 4 A guide groove 28 is provided on the surface, and the number of the guide grooves 28 is not less than twelve, and not less than twelve guide grooves 28 are in an annular array. An annular mounting groove 29 is provided inside the top wall of the box body 1 and is located outside the feed hopper 4. The outer surface of the feed hopper 4 is slidably connected to the inner surface of the annular mounting groove 29 through a positioning ring 30. A transmission ring 31 is fixedly connected to the outer surface of the feed hopper 4. A synchronous motor 33 is fixedly connected to the top of the box body 1 through two support rods 32. A traction rod 34 is fixedly connected to the output end at the bottom of the synchronous motor 33. The outer surface of the traction rod 34 is transmission-connected to the transmission ring 31 through a traction belt 35. Stabilizing rods 36 are fixedly connected to both sides of the primary filter cage 6. A stabilizing roller 37 is fixedly connected to the end of the stabilizing rod 36 away from the primary filter cage 6.The number of the stabilizer bars 36 and the stabilizer rollers 37 is not less than six and they are arranged in a rectangular array.

[0024] The working principle of the present invention is as follows: By arranging the diversion groove 28 in the feed hopper 4, it effectively avoids the situation of feed blockage and effectively improves the feed efficiency. By setting the synchronous motor 33 to control the rotation of the feed hopper 4, it effectively makes the feed rotate and enter, and then the feed will be dispersed due to rotation, and further effectively disperses the feed to improve the filtration efficiency and quality. By controlling the rotation of the primary filtration cage 6 with the driving motor 10, it effectively performs primary filtration and purification on the feed. Then, the feed after primary filtration and purification falls on the upper surface of the secondary filter screen 15. Start the stepping motor 20 to control the rotation of the rotating rod 21. The rotation of the rotating rod 21 causes the force-applying cam 22 to intermittently apply force to the force-receiving frustum 19. The intermittent force on the force-receiving frustum 19 causes the secondary filter screen 15 to reciprocate in the left-right direction under the action of the return spring 14. Then, through the rapid reciprocating motion, the effects of improving the filtration and purification efficiency and accuracy are achieved.

[0025] The above is only the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art of this technology, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention. The structures, devices, and operation methods not specifically described and explained in the present invention, unless otherwise specifically stated and limited, are implemented according to the conventional means in the art.

Claims

1. A filtration and purification device applied to biopharmaceutical production, characterized in that: It includes a box body (1), a discharge pipe (2) is arranged at the lower right of the box body (1), a pipe valve (3) is arranged on the outer surface of the discharge pipe (2), a feed hopper (4) is arranged at the top of the box body (1), a connecting bearing (5) located outside the feed hopper (4) is fixedly connected to the inner wall at the top of the box body (1), a primary filter cage (6) located directly below the feed hopper (4) is fixedly connected to the inner surface of the connecting bearing (5), a feed inlet (7) is opened at the top of the primary filter cage (6), a primary filter screen (8) is arranged on the outer surface of the primary filter cage (6), a driving motor (10) located below the primary filter cage (6) is fixedly connected to the inner surface of the box body (1) through a fixing rod (9), a rotating shaft (11) is fixedly connected to the output end at the top of the driving motor (10), the top end of the rotating shaft (11) is fixedly connected to the center of the lower surface of the primary filter cage (6), an installation ring (13) is fixedly connected to the inner wall of the box body (1), a secondary filter screen (15) is fixedly connected to the inner surface of the installation ring (13) through a return spring (14), a vibration motor (18) is fixedly connected to the bottom of the secondary filter screen (15), a force-receiving frustum (19) located on the left side of the vibration motor (18) is fixedly connected to the bottom of the secondary filter screen (15), a stepping motor (20) located below the installation ring (13) is fixedly connected to the inner wall on the left side of the box body (1), a rotating rod (21) is fixedly connected to the output end on the right side of the stepping motor (20), a force-applying cam (22) located in front of the force-receiving frustum (19) is fixedly connected to the right end of the rotating rod (21), a rotating rod (24) located below the stepping motor (20) is rotatably connected to the inner wall on the left side of the box body (1) through a combined bearing (23), a spiral pushing plate (25) is fixedly connected to the outer surface of the rotating rod (24), and the outer surface of the rotating rod (24) is in transmission connection with the rotating rod (21) through a transmission belt (26).

2. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: A flow guide cover (12) located above the driving motor (10) is fixedly connected to the outer surface of the rotating shaft (11).

3. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: Guide grooves (16) located on both sides of the secondary filter screen (15) are opened on the inner wall of the back surface of the box body (1), and the top and bottom of the secondary filter screen (15) are slidably connected to the inner surface of the guide grooves (16) through guide rods (17).

4. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, wherein: Two limiting discs (27) located on both sides of the transmission belt (26) are fixedly connected to the outer surfaces of the rotating rod (21) and the rotating rod (24).

5. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: A flow guide groove (28) is opened on the inner surface of the feed hopper (4), the number of the flow guide grooves (28) is not less than twelve, and not less than twelve of the flow guide grooves (28) are arranged in an annular array.

6. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: An annular mounting groove (29) located outside the feed hopper (4) is formed inside the top wall of the box body (1). The outer surface of the feed hopper (4) is slidably connected to the inner surface of the annular mounting groove (29) through a positioning ring (30). A transmission ring (31) is fixedly connected to the outer surface of the feed hopper (4). A synchronous motor (33) is fixedly connected to the top of the box body (1) through two support rods (32). The output end at the bottom of the synchronous motor (33) is fixedly connected to a traction rod (34). The outer surface of the traction rod (34) is drivingly connected to the transmission ring (31) through a traction belt (35).

7. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: Stabilizing rods (36) are fixedly connected to both sides of the primary filter cage (6). The end of the stabilizing rod (36) far from the primary filter cage (6) is fixedly connected to a stabilizing roller (37).

8. The filtration and purification equipment applied to biopharmaceutical production according to claim 1, characterized in that: The number of the stabilizing rods (36) and the stabilizing rollers (37) is not less than six and they are arranged in a rectangular array.

9. The filtration and purification equipment applied to biopharmaceutical production according to claim 2, characterized in that: The outer surface of the flow deflector (12) is a curved surface, and a sliding aid pad is arranged on the outer surface of the flow deflector (12).

10. The filtration and purification equipment applied to biopharmaceutical production according to claim 3, characterized in that: Wear-resistant pads are arranged on the inner surface of the guide groove (16) and the outer surface of the guide rod (17).

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