Chondroitin sulfate extraction device for microbial fermentation

Abstract

The invention discloses a chondroitin sulfate extraction device for microbial fermentation, and relates to the technical field of chondroitin extraction.The chondroitin sulfate extraction device for microbial fermentation is characterized in that the chondroitin sulfate extraction device for microbial fermentation comprises a supporting plate, a fermentation device, a grinding device and a smashing device, the fermentation device is arranged on one side of the top end of the supporting plate, and the grinding device is arranged on one side of the top end of the supporting plate; the grinding device is arranged in the middle of the top end of the supporting plate, the smashing device is arranged on the other side of the top end of the supporting plate, a lead screw is rotationally connected to the middle of the top end of the inner side wall of the tank body, adjusting gears are fixedly connected to the middle of the other side of a turning plate, and four stirring fan blades are arranged on the side wall of a fixing rod in a circumferential array mode. The chondroitin extraction device has the effects that the mixing efficiency of raw materials can be improved and the fermentation efficiency can be improved by arranging the fermentation device and utilizing longitudinal stirring of a turning plate and transverse stirring of stirring fan blades, and crushed bones can promote the uniformity of fermentation operation and improve the working efficiency of chondroitin extraction by arranging the grinding device and the crushing device.

Description

Technical Field

[0001] The present invention relates to the technical field of chondroitin extraction, and more specifically, it relates to a chondroitin sulfate extraction device for microbial fermentation. Background Art

[0002] Chondroitin sulfate is a class of glycosaminoglycans covalently linked to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain is composed of alternating glucuronic acid and N-acetylgalactosamine disaccharide units, and is linked to the serine residue of the core protein through a glycosyl-like linker region. Chondroitin sulfate exists in all organisms from nematodes to humans except plants and plays many important physiological functions. The extraction methods of chondroitin sulfate mainly include chemical extraction method, enzymatic hydrolysis method and microbial fermentation method. Among them, the microbial fermentation method has gradually become a research hotspot due to its environmental protection, high efficiency and strong controllability.

[0003] The prior art treats animal cartilage tissue with chemical reagents such as strong acids and strong alkalis to destroy the tissue structure and release chondroitin sulfate. However, there is a problem that the volume of bone blocks added before fermentation is large, resulting in a smaller contact area between microorganisms and bones during the fermentation process, and thus the extraction efficiency of chondroitin is reduced. Therefore, those skilled in the art have provided a chondroitin sulfate extraction device for microbial fermentation to solve the problems raised in the above background art.

[0004] Therefore, in order to solve the above technical problems, the present application proposes a chondroitin sulfate extraction device for microbial fermentation. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a chondroitin sulfate extraction device for microbial fermentation.

[0006] To achieve the above purpose, the present invention provides the following technical solution: A chondroitin sulfate extraction device for microbial fermentation, including a support plate, a fermentation device, a grinding device, and a crushing device. The fermentation device is arranged on one side of the top of the support plate, the grinding device is arranged in the middle of the top of the support plate, and the crushing device is arranged on the other side of the top of the support plate. The fermentation device includes a tank body. In the middle of the top inner wall of the tank body, a lead screw is rotatably connected. At the top of the inner wall of the tank body and on the side wall of the lead screw, a limiting frame is fixedly connected. A slider is threadedly connected to the side wall of the lead screw. On the side wall of the slider, three turning plates are arranged in a circumferential array. In the middle of the other side of each turning plate, an adjusting gear is fixedly connected respectively. On the inner wall of the tank body, three racks are arranged in a circumferential array. In the middle of the bottom end of the limiting frame, a fixing rod is rotatably connected. On the side wall of the fixing rod, four stirring fan blades are arranged in a circumferential array.

[0007] Preferably, the grinding device includes a grinding barrel. At the bottom end of the inner side wall of the grinding barrel, a rotating shaft is rotatably connected. On the side wall of the rotating shaft, two grinding fan blades are fixedly connected. In the middle of the bottom end of the grinding barrel, a protective shell is fixedly connected. At the top end of the inner side wall of the protective shell, a driven bevel gear is rotatably connected. On the other side of the inner side wall of the protective shell, a driving bevel gear is rotatably connected. On the other side of the top end of the grinding barrel, a blanking plate is fixedly connected. At the bottom end of the grinding barrel, a feeding device is arranged. The feeding device includes a connecting pipe. On the side wall of the connecting pipe, a third valve is fixedly connected. The other end of the connecting pipe is fixedly connected to a feeding pipe. On the inner side wall of the feeding pipe, a spiral feeding shaft is rotatably connected. One end of the feeding pipe is fixedly connected to a second motor. The grinding barrel is fixedly connected to the middle of the top end of the support plate, and the other end of the feeding pipe is fixedly connected to the side wall of the tank body.

[0008] Preferably, the crushing device includes a third motor and a lower housing. On the side wall of the output end of the third motor, a driving belt pulley is fixedly connected. At a position above the middle of the inner side wall of the lower housing, a rotating frame is rotatably connected. At the bottom end of the inner side wall of the lower housing, a filter screen is fixedly connected. At a position below the middle of one side of the lower housing, a second discharge port is formed. At the top end of the lower housing, an upper housing is hinged. At the top end of the upper housing, a second feeding port is fixedly connected. At a position above the middle of the other side of the lower housing, a driven belt pulley is rotatably connected. On the inner side wall of the rotating frame, a number of crushing blades are arranged in a circumferential array. The third motor is fixedly connected to one side of the top end of the support plate.

[0009] Preferably, at the middle of the top end of the tank body, a first motor is fixedly connected. At one side of the top end of the tank body, a one-way exhaust pipe is fixedly connected. At the other side of the top end of the tank body, a first feeding port is fixedly connected. On the side wall of the first feeding port, a first valve is fixedly connected. At a position below the middle of the other side of the tank body, a first discharge port is fixedly connected. On the side wall of the first discharge port, a second valve is fixedly connected. The output end of the first motor penetrates through the middle of the top end of the tank body and is fixedly connected to the top end of the lead screw. The top end of the fixed rod penetrates through the bottom end of the limiting frame and is fixedly connected to the bottom end of the lead screw. The three turning plates are respectively rotatably connected to the side wall of the slider. The three racks are meshed with the three limiting frames. The side wall of the slider is respectively slidably connected to the inner side wall of the limiting frame.

[0010] Preferably, the bottom end of the rotating shaft penetrates through the middle of the bottom end of the inner side wall of the grinding barrel, the top end of the protective shell and is fixedly connected to the top end of the driven bevel gear. The driven bevel gear is meshed with the driving bevel gear. The output end of the second motor penetrates through one end of the feeding pipe and is fixedly connected to one end of the spiral feeding shaft. And the connecting pipe penetrates through the third valve and is communicated with the inside of the grinding barrel.

[0011] Preferably, the output end of the third motor penetrates through the driving belt pulley and the other side wall of the protective shell and is fixedly connected to the middle of the driving bevel gear. The side wall of the lower housing is fixedly connected to the other side of the blanking plate, and the blanking plate is located above the blanking plate.

[0012] Preferably: The middle part of the other side of the rotating frame penetrates through the lower housing and is fixedly connected to the middle part of the driven pulley. The driving pulley and the side wall of the driven pulley are connected by a belt. The top ends of the upper housing and the lower housing are mutually adapted. The second feeding port is communicated with the inside of the upper housing. The bottom end of the lower housing is fixedly connected to one side of the top end of the support plate. Several of the crushing blades are respectively rotatably connected to the inner side wall of the rotating frame.

[0013] 1. In the present invention, by providing a fermentation device, after the bone meal enters the tank body, enzymes required for fermentation are added into the tank body through the first feeding port, and at the same time, the pH value in the tank body is adjusted. At this time, the first valve, the second valve and the third valve are closed, so that the tank body is in a sealed state. The first motor is turned on to drive the lead screw to rotate, so that the slider can slide up and down in the limiting frame. And during the up and down movement of the turning plate, the turning plate will turn the raw materials up and down. And as the turning plate moves, the turning plate will rotate under the meshing action of the rack and the adjusting gear. And the lead screw will also drive the fixed rod to rotate, so that the stirring fan blades further stir the raw materials. And before fermentation, an appropriate amount of water can be added into the one-way exhaust pipe. During the fermentation process, the one-way exhaust pipe will be used for exhaust work. The longitudinal stirring of the turning plate and the transverse stirring of the stirring fan blades can improve the mixing efficiency of the raw materials and improve the fermentation efficiency.

[0014] 2. In the present invention, by providing a grinding device and a crushing device, the bone blocks are added into the upper housing through the second feeding port. The third motor is turned on, and the third motor drives the driving pulley to rotate. Under the transmission of the belt, the driven pulley can drive the rotating frame to rotate. Since there are multiple crushing blades arranged on the rotating frame, under the action of centrifugal force, the crushing blades will strike the bone blocks in the lower housing, making them become fine. Those smaller than the diameter of the filter mesh opening will be discharged through the second discharge port, realizing the preliminary crushing of the bone blocks. The crushed bone blocks will fall into the grinding barrel through the blanking plate. The output end of the third motor continues to drive the driving helical gear to rotate, so as to realize the driven helical gear driving the rotating shaft to rotate. Under the rotation of the grinding fan blades on the side wall of the rotating shaft, the bone blocks can be further ground and crushed. And by driving the rotation of the spiral feeding shaft by the second motor, the bone meal in the grinding barrel can be discharged into the tank body, so that it can have a larger contact area with microorganisms during the fermentation process, improving the reaction efficiency. And the crushed bones can promote the uniformity of the fermentation operation and improve the working efficiency of chondroitin extraction. Description of the Drawings

[0015] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The schematic embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings: Figure 1Schematic structural diagram of the present invention; Figure 2 Front view structural diagram of the present invention; Figure 3 Front view structural diagram of the grinding device and the crushing device in the present invention; Figure 4 Top view structural diagram of the grinding device and the crushing device in the present invention; Figure 5 Schematic structural diagram of the fermentation device in the present invention; Figure 6 Front view structural diagram of the fermentation device in the present invention; Figure 7 Internal front view structural diagram of the fermentation device in the present invention; Figure 8 Internal structural diagram of the fermentation device in the present invention.

[0016] 1. Fermentation device; 101. Tank body; 102. One-way exhaust pipe; 103. First motor; 104. First feeding port; 105. First valve; 106. First discharging port; 107. Second valve; 108. Rack; 109. Lead screw; 1010. Limiting frame; 1011. Adjusting gear; 1012. Turning plate; 1013. Slide block; 1014. Fixed rod; 1015. Stirring fan blade; 2. Feeding device; 201. Second motor; 202. Connecting pipe; 203. Feeding pipe; 204. Screw feeding shaft; 205. Third valve; 3. Grinding device; 301. Grinding barrel; 302. Feeding plate; 303. Protective shell; 304. Rotating shaft; 305. Grinding fan blade; 306. Driven bevel gear; 307. Driving bevel gear; 4. Crushing device; 401. Second feeding port; 402. Upper shell; 403. Lower shell; 404. Driving belt pulley; 405. Third motor; 406. Second discharging port; 407. Rotating frame; 408. Driven belt pulley; 409. Crushing blade; 4010. Filter screen; 5. Support plate. Detailed implementation manners

[0017] Embodiment 1

[0018] As Figure 1 - Figure 4As shown in the figure, the present invention provides a chondroitin sulfate extraction device for microbial fermentation, including a grinding device 3. The grinding device 3 includes a grinding barrel 301. At the bottom end of the inner side wall of the grinding barrel 301, a rotating shaft 304 is rotatably connected. On the side wall of the rotating shaft 304, two grinding fan blades 305 are fixedly connected. In the middle of the bottom end of the grinding barrel 301, a protective shell 303 is fixedly connected. At the top end of the inner side wall of the protective shell 303, a driven bevel gear 306 is rotatably connected. On the other side of the inner side wall of the protective shell 303, a driving bevel gear 307 is rotatably connected. On the other side of the top end of the grinding barrel 301, a blanking plate 302 is fixedly connected. At the bottom end of the grinding barrel 301, a feeding device 2 is provided. The feeding device 2 includes a connecting pipe 202. On the side wall of the connecting pipe 202, a third valve 205 is fixedly connected. The other end of the connecting pipe 202 is fixedly connected to a feeding pipe 203. Inside the side wall of the feeding pipe 203, a spiral feeding shaft 204 is rotatably connected. One end of the feeding pipe 203 is fixedly connected to a second motor 201. The grinding barrel 301 is fixedly connected to the middle of the top end of a support plate 5, and the other end of the feeding pipe 203 is fixedly connected to the side wall of a tank body 101.

[0019] The crushing device 4 includes a third motor 405 and a lower housing 403. On the side wall of the output end of the third motor 405, a driving pulley 404 is fixedly connected. At a position above the inner side wall of the lower housing 403, a rotating frame 407 is rotatably connected. At the bottom end of the inner side wall of the lower housing 403, a filter screen 4010 is fixedly connected. At a position below one side of the lower housing 403, a second discharge port 406 is provided. At the top end of the lower housing 403, an upper housing 402 is hinged. At the top end of the upper housing 402, a second feeding port 401 is fixedly connected. At a position above the other side of the lower housing 403, a driven pulley 408 is rotatably connected. Inside the inner side wall of the rotating frame 407, a plurality of crushing blades 409 are arranged in a circumferential array. The third motor 405 is fixedly connected to one side of the top end of the support plate 5.

[0020] The bottom end of the rotating shaft 304 penetrates through the middle of the bottom end of the inner side wall of the grinding barrel 301, the top end of the protective shell 303 and is fixedly connected to the top end of the driven bevel gear 306. The driven bevel gear 306 is meshed and connected with the driving bevel gear 307. The output end of the second motor 201 penetrates through one end of the feeding pipe 203 and is fixedly connected to one end of the spiral feeding shaft 204, and the connecting pipe 202 penetrates through the third valve 205 and is communicated with the inside of the grinding barrel 301.

[0021] The output end of the third motor 405 penetrates through the driving pulley 404 and the other side wall of the protective shell 303 and is fixedly connected to the middle of the driving bevel gear 307. The side wall of the lower housing 403 is fixedly connected to the other side of the blanking plate 302, and the blanking plate 302 is located above the blanking plate 302.

[0022] On the other side of the rotating frame 407, in the middle, it penetrates through the lower housing 403 and is fixedly connected to the middle of the driven pulley 408. The driving pulley 404 and the side wall of the driven pulley 408 are connected by a belt. The upper housing 402 and the top end of the lower housing 403 are mutually adapted. The second feeding port 401 is communicated with the inside of the upper housing 402. The bottom end of the lower housing 403 is fixedly connected to one side of the top end of the support plate 5. A plurality of crushing blades 409 are respectively rotatably connected to the inner side wall of the rotating frame 407.

[0023] Put the bone blocks into the upper housing 402 through the second feeding port 401. Turn on the third motor 405. Use the third motor 405 to drive the driving pulley 404 to rotate. Under the transmission of the belt, the driven pulley 408 can drive the rotating frame 407 to rotate. Since there are multiple crushing blades 409 arranged on the rotating frame 407, under the action of centrifugal force, the crushing blades 409 will strike the bone blocks in the lower housing 403, making them become fine. Those smaller than the mesh diameter of the filter screen 4010 will be discharged through the second discharge port 406, realizing the preliminary crushing of the bone blocks. The crushed bone blocks will fall into the grinding barrel 301 through the blanking plate 302. The output end of the third motor 405 continues to drive the driving bevel gear 307 to rotate, so as to realize the driven bevel gear 306 driving the rotating shaft 304 to rotate. Under the rotation of the grinding fan blades 305 on the side wall of the rotating shaft 304, the bone blocks can be further ground and crushed, and the rotation of the screw feeding shaft 204 driven by the second motor 201 can discharge the bone powder in the grinding barrel 301 into the tank body 101.

[0024] Embodiment 2

[0025] As Figure 5 - Figure 8 As shown in the figure, the present invention provides a chondroitin sulfate extraction device for microbial fermentation, including a support plate 5, a fermentation device 1, a grinding device 3, and a crushing device 4. The fermentation device 1 is arranged on one side of the top end of the support plate 5. The grinding device 3 is arranged in the middle of the top end of the support plate 5. The crushing device 4 is arranged on the other side of the top end of the support plate 5. The fermentation device 1 includes a tank body 101. In the middle of the top end of the inner side wall of the tank body 101, a lead screw 109 is rotatably connected. At the top end of the inner side wall of the tank body 101 and on the side wall of the lead screw 109, a limiting frame 1010 is fixedly connected. A slider 1013 is threadedly connected to the side wall of the lead screw 109. On the side wall of the slider 1013, three turning plates 1012 are arranged in a circumferential array. In the middle of the other side of the turning plate 1012, adjusting gears 1011 are respectively fixedly connected. On the inner side wall of the tank body 101, three racks 108 are arranged in a circumferential array. In the middle of the bottom end of the limiting frame 1010, a fixing rod 1014 is rotatably connected. On the side wall of the fixing rod 1014, four stirring fan blades 1015 are arranged in a circumferential array.

[0026] A first motor 103 is fixedly connected to the middle of the top end of the tank body 101. A one-way exhaust pipe 102 is fixedly connected to one side of the top end of the tank body 101. A first feeding port 104 is fixedly connected to the other side of the top end of the tank body 101. A first valve 105 is fixedly connected to the side wall of the first feeding port 104. A first discharging port 106 is fixedly connected to a position near the lower part of the other side of the tank body 101. A second valve 107 is fixedly connected to the side wall of the first discharging port 106. The output end of the first motor 103 penetrates through the middle of the top end of the tank body 101 and is fixedly connected to the top end of the lead screw 109. The top end of the fixed rod 1014 penetrates through the bottom end of the limiting frame 1010 and is fixedly connected to the bottom end of the lead screw 109. The three turning plates 1012 are respectively rotatably connected to the side walls of the sliders 1013. The three racks 108 are meshed with the three limiting frames 1010. The side walls of the sliders 1013 are respectively slidably connected to the inner side walls of the limiting frames 1010.

[0027] After the bone meal enters the tank body 101, enzymes required for fermentation are added into the tank body 101 through the first feeding port 104, and at the same time, the pH value in the tank body 101 is adjusted. At this time, the first valve 105, the second valve 107 and the third valve 205 are closed, so that the tank body 101 is in a sealed state. The first motor 103 is turned on to drive the lead screw 109 to rotate, so that the slider 1013 can slide up and down in the limiting frame 1010. And during the up and down movement of the turning plate 1012, the turning plate 1012 will turn the raw materials up and down. And as the turning plate 1012 moves, the turning plate 1012 will rotate under the meshing action of the rack 108 and the adjusting gear 1011. And the lead screw 109 will also drive the fixed rod 1014 to rotate, so that the stirring fan blades 1015 further stir the raw materials. And an appropriate amount of water can be added into the one-way exhaust pipe 102 before fermentation. During the fermentation process, the one-way exhaust pipe 102 will be used for exhaust work.

[0028] The above is only a preferred embodiment of the present invention, and it is not intended to limit the present invention in any form; any ordinary technician in the industry can smoothly implement the present invention according to the illustrations in the specification and the above description; however, any slight changes, modifications and evolutions made by those skilled in the art within the scope of the technical solution of the present invention by using the technical content disclosed above are equivalent embodiments of the present invention; at the same time, any equivalent changes, modifications and evolutions made to the above embodiments according to the essential technology of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

1. A chondroitin sulfate extraction device for microbial fermentation, comprising a support plate (5), a fermentation device (1), a grinding device (3), and a crushing device (4). The fermentation device (1) is arranged on one side of the top of the support plate (5), the grinding device (3) is arranged in the middle of the top of the support plate (5), and the crushing device (4) is arranged on the other side of the top of the support plate (5), characterized in that: The fermentation device (1) includes a tank body (101). In the middle of the top of the inner side wall of the tank body (101), a lead screw (109) is rotatably connected. At the top of the inner side wall of the tank body (101) and on the side wall of the lead screw (109), a limiting frame (1010) is fixedly connected. A slider (1013) is threadedly connected to the side wall of the lead screw (109). On the side wall of the slider (1013), three turning plates (1012) are arranged in a circumferential array. In the middle of the other side of each turning plate (1012), an adjusting gear (1011) is fixedly connected respectively. On the inner side wall of the tank body (101), three racks (108) are arranged in a circumferential array. In the middle of the bottom end of the limiting frame (1010), a fixed rod (1014) is rotatably connected. On the side wall of the fixed rod (1014), four stirring fan blades (1015) are arranged in a circumferential array.

2. The chondroitin sulfate extraction device for microbial fermentation according to claim 1, characterized in that: The grinding device (3) includes a grinding barrel (301). At the bottom end of the inner side wall of the grinding barrel (301), a rotating shaft (304) is rotatably connected. On the side wall of the rotating shaft (304), two grinding fan blades (305) are fixedly connected. In the middle of the bottom end of the grinding barrel (301), a protective shell (303) is fixedly connected. At the top of the inner side wall of the protective shell (303), a driven bevel gear (306) is rotatably connected. On the other side of the inner side wall of the protective shell (303), a driving bevel gear (307) is rotatably connected. On the other side of the top of the grinding barrel (301), a blanking plate (302) is fixedly connected. At the bottom end of the grinding barrel (301), a feeding device (2) is provided. The feeding device (2) includes a connecting pipe (202). On the side wall of the connecting pipe (202), a third valve (205) is fixedly connected. The other end of the connecting pipe (202) is fixedly connected to a feeding pipe (203). On the inner side wall of the feeding pipe (203), a spiral feeding shaft (204) is rotatably connected. One end of the feeding pipe (203) is fixedly connected to a second motor (201). The grinding barrel (301) is fixedly connected to the middle of the top of a support plate (5), and the other end of the feeding pipe (203) is fixedly connected to the side wall of the tank body (101).

3. The chondroitin sulfate extraction device for microbial fermentation according to claim 1, characterized in that: The crushing device (4) includes a third motor (405) and a lower housing (403). On the side wall of the output end of the third motor (405), a driving pulley (404) is fixedly connected. At a position above the inner side wall of the lower housing (403), a rotating frame (407) is rotatably connected. At the bottom end of the inner side wall of the lower housing (403), a filter screen (4010) is fixedly connected. At a position below one side of the lower housing (403), a second discharge port (406) is opened. At the top of the lower housing (403), an upper housing (402) is hinged. At the top of the upper housing (402), a second feeding port (401) is fixedly connected. At a position above the other side of the lower housing (403), a driven pulley (408) is rotatably connected. On the inner side wall of the rotating frame (407), a number of crushing blades (409) are arranged in a circumferential array. The third motor (405) is fixedly connected to one side of the top of the support plate (5).

4. A chondroitin sulfate extraction device for microbial fermentation according to claim 1, characterized in that: In the middle of the top of the tank body (101), a first motor (103) is fixedly connected. On one side of the top of the tank body (101), a one-way exhaust pipe (102) is fixedly connected. On the other side of the top of the tank body (101), a first feeding port (104) is fixedly connected. On the side wall of the first feeding port (104), a first valve (105) is fixedly connected. At a position near the lower part on the other side of the tank body (101), a first discharging port (106) is fixedly connected. On the side wall of the first discharging port (106), a second valve (107) is fixedly connected. The output end of the first motor (103) penetrates through the middle of the top of the tank body (101) and is fixedly connected to the top end of a lead screw (109). The top end of the fixed rod (1014) penetrates through the bottom end of the limit frame (1010) and is fixedly connected to the bottom end of the lead screw (109). The three turning plates (1012) are respectively rotatably connected to the side wall of the slider (1013). The three racks (108) are meshed with the three limit frames (1010). The side wall of the slider (1013) is slidably connected to the inner side wall of the limit frame (1010).

5. A chondroitin sulfate extraction device for microbial fermentation according to claim 2, characterized in that: The bottom end of the rotating shaft (304) penetrates through the middle of the inner side wall at the bottom of the grinding barrel (301) and is fixedly connected to the top end of the protective shell (303) and the top end of the driven bevel gear (306). The driven bevel gear (306) is meshed with the driving bevel gear (307). The output end of the second motor (201) penetrates through one end of the feeding pipe (203) and is fixedly connected to one end of the spiral feeding shaft (204). And the connecting pipe (202) penetrates through the third valve (205) and is communicated with the inside of the grinding barrel (301).

6. The chondroitin sulfate extraction device for microbial fermentation according to claim 3, wherein: The output end of the third motor (405) penetrates through the driving belt pulley (404) and the other side wall of the protective shell (303) and is fixedly connected to the middle of the driving bevel gear (307). The side wall of the lower shell (403) is fixedly connected to the other side of the blanking plate (302). And the blanking plate (302) is located above the blanking plate (302).

7. A chondroitin sulfate extraction device for microbial fermentation according to claim 3, characterized in that: The middle of the other side of the rotating frame (407) penetrates through the lower shell (403) and is fixedly connected to the middle of the driven belt pulley (408). The driving belt pulley (404) and the side wall of the driven belt pulley (408) are connected by a belt. The upper shell (402) and the top end of the lower shell (403) are mutually adapted. The second feeding port (401) is communicated with the inside of the upper shell (402). The bottom end of the lower shell (403) is fixedly connected to one side of the top end of the support plate (5). A plurality of crushing blades (409) are respectively rotatably connected to the inner side wall of the rotating frame (407).

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