Online solid phase extraction-liquid chromatography detection method
By using polyacrylonitrile-hydrophilic lipophilic equilibrium copolymer composite nanofibers as solid-phase adsorbents, the problem of combining solid-phase extraction and liquid chromatography is solved, and the online sample processing and detection is integrated, which improves detection efficiency and accuracy, and is suitable for efficient separation of a variety of complex samples.
Patent Information
- Application Number
- CN202510736197.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-04
- Publication Date
- 2025-08-29
- Estimated Expiration
- 2045-06-04
AI Technical Summary
The existing solid-phase extraction technology is difficult to be used online with liquid chromatography, which makes the sample preprocessing time-consuming and labor-intensive and prone to errors, and high concentrations of organic solvents affect the detection effect during the elution process.
Polyacrylonitrile-hydrophilic lipophilic equilibrium copolymer composite nanofibers are used as solid-phase adsorbents, combined with specific eluents, to achieve adsorption and elution of target analytes. They are suitable for online enrichment and separation of hydrophilic, hydrophobic and amphoteric components, and the composite nanofibers are prepared through electrospinning technology to optimize their structure and performance.
It realizes the online combination of solid phase extraction and liquid chromatography, simplifies operational processes, reduces manual errors, improves detection sensitivity and accuracy, and is suitable for efficient processing of a variety of complex samples, reduces time and consumption, and is in line with the concept of green chemistry.