Chromatographic column filling device

Abstract

The invention relates to the technical field of chromatographic analysis, and discloses a chromatographic column filling device which comprises a chromatographic column body and a support seat, a feeding end is arranged at the top of the chromatographic column body, a discharging end is arranged at the bottom of the chromatographic column body, and a valve is arranged at the discharging end; a power mechanism, a Y-axis mechanism, a metering plate mechanism and a laminating mechanism are arranged in the chromatographic column body; the power mechanism is connected with the Y-axis mechanism, the Y-axis mechanism is connected with the laminating mechanism, and the metering plate mechanism is arranged on the Y-axis mechanism; the Y-axis mechanism comprises an upper connecting column, the upper connecting column is connected with the power mechanism, a guide rotating cylinder is arranged at the bottom of the upper connecting column, a first guide groove is formed in the upper portion of the surface of the guide rotating cylinder, a bottom connecting cylinder is arranged at the bottom of the guide rotating cylinder, an outer lifting column is arranged on the outer side of the guide rotating cylinder, and limiting rods are arranged on the two corresponding sides of the upper portion of the outer lifting column. The device has the beneficial effects that the trouble and labor amount of manual operation in the prior art are solved, the filling efficiency is improved, meanwhile, vibration devices do not need to be additionally arranged on the periphery, and the problem of complex structure is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of chromatographic analysis, and more specifically, to a chromatographic column filling device. Background Art

[0002] Chromatography is a separation and analysis method, and separation is the core. Therefore, the chromatographic column responsible for separation is the heart of the chromatographic system. Since there are many factors affecting the performance of the chromatographic column, among which the properties and shapes of the chromatographic packing, as well as the particle size and uniformity, will all affect the separation performance of chromatography. And the more uniformly the packing is filled, the smaller the longitudinal diffusion of the packing is, and the higher the column efficiency of the chromatographic column is. Therefore, the filling operation of the chromatographic column is particularly important.

[0003] In the prior art, in order to improve the filling rate of the chromatographic column, a short rod is generally used. During the filling process, the chromatographic column is continuously patted to promote the filling of the packing in the chromatographic column. And this process undoubtedly increases the labor intensity of the staff, and the filling efficiency is not high. In addition, although currently on the market, a vibration device is used externally to pat the chromatographic column to promote filling, this undoubtedly increases the total area and cost, and the structure of the chromatographic column filling device with an additional vibration device becomes complicated, and the filling effect is not good. Summary of the Invention

[0004] The technical task of the present invention is to provide a chromatographic column filling device to solve the above problems in view of the above deficiencies.

[0005] The technical solution of the present invention is realized as follows:

[0006] A chromatographic column filling device includes a chromatographic column body and a support seat. The top of the chromatographic column body is provided with a feed end, the bottom of the chromatographic column body is provided with a discharge end, and a valve is provided on the discharge end; a power mechanism, a Y-axis mechanism, a metering plate mechanism and a stacking mechanism are arranged in the chromatographic column body; the power mechanism is connected to the Y-axis mechanism, the Y-axis mechanism is connected to the stacking mechanism, and the metering plate mechanism is arranged on the Y-axis mechanism; the Y-axis mechanism includes an upper connecting column, the upper connecting column is connected to the power mechanism, a guiding rotating cylinder is provided at the bottom of the upper connecting column, a first guiding groove is provided on the upper part of the surface of the guiding rotating cylinder, a bottom connecting cylinder is provided at the bottom of the guiding rotating cylinder, an outer lifting column is arranged outside the guiding rotating cylinder, limiting rods are provided on both sides corresponding to the upper part of the outer lifting column, the inner ends of the limiting rods are located in the first guiding groove, a lower connecting column is provided at the bottom of the outer lifting column, the lower connecting column is connected to the metering plate mechanism, the bottom connecting cylinder penetrates through the lower connecting column, and the bottom connecting cylinder is connected to the stacking mechanism.

[0007] Preferably, a first buffer block is provided on the chromatographic column body, a second buffer block is provided on the chromatographic column body at the bottom of the first buffer block, a third buffer block is provided at the lower part of the chromatographic column body, and the support seat is fixed on the third buffer block.

[0008] Preferably, the power mechanism is arranged at the feeding end. The power mechanism includes a rotating end block which is embedded in the inner wall of the first buffer block. The inner wall of the rotating end block is provided with inner wall teeth, and an outer gear sleeve meshing with the inner wall teeth is sleeved on the upper part of the upper connecting column.

[0009] Preferably, the inner wall of the second buffer block is provided with an inner sliding groove, and sliding blocks are arranged on both sides corresponding to each other in the inner sliding groove. The sides of the sliding blocks away from the inner sliding groove are respectively fixed on the sides of the corresponding limiting rods.

[0010] Preferably, a blanking channel is arranged in a penetrating connection inside the upper connecting column, the guiding rotating cylinder and the bottom connecting cylinder, and the bottom connecting cylinder penetrates through the metering plate mechanism.

[0011] Preferably, the metering plate mechanism includes a metering plate. A baffle is arranged on the side of the metering plate, and a metering bottom plate is arranged at the bottom of the baffle. A plurality of metering holes are arranged on both the metering plate and the metering bottom plate, and the metering holes are located at the position inside the bottom connecting cylinder.

[0012] Preferably, the laminating mechanism includes an outer rotating cylinder. A first hollow plate is arranged at the top of the outer rotating cylinder, and the top of the first hollow plate is connected to the bottom of the bottom connecting cylinder. An inner lifting column is arranged inside the outer rotating cylinder. A second hollow plate is arranged at the top of the inner lifting column. A reset spring is arranged at the center of the top of the second hollow plate, and the top of the reset spring is fixed at the center of the bottom of the first hollow plate; a plurality of limiting columns are arranged on the upper part of the surface of the inner lifting column, and a second guiding groove matching with the limiting columns is arranged on the inner wall of the outer rotating cylinder.

[0013] Preferably, a cavity column is arranged at the lower inner part of the third buffer block. A plurality of discharge holes are arranged at both the top and the bottom of the cavity column. The lower discharge holes correspond to the upper discharge holes. A plurality of ropes are arranged at the bottom of the cavity column, and a rubber sphere is arranged at the bottom of the ropes.

[0014] Compared with the prior art, the advantages and positive effects of the present invention are as follows:

[0015] 1. The filling device includes a power mechanism, a Y-axis mechanism, a metering plate mechanism, and a stacking mechanism. A power mechanism is provided at the feeding port of the chromatographic column. The Y-axis mechanism is connected to the power mechanism, and the metering plate mechanism is connected to the Y-axis mechanism. After the power mechanism operates, it will drive the Y-axis mechanism and the metering plate mechanism to move downward as a whole, and convey the filler downward along the downward movement trajectory. During the conveying process, the filler is monitored by the metering plate to prevent it from being too large. At the same time, during the filling operation, the Y-axis direction of the chromatographic column is kept from tilting. After the power mechanism operates and the filler forms a downward movement trajectory, the vertical gravity generated will squeeze the stacking mechanism arranged below in the chromatographic column. The stacking mechanism will be stacked under the action of force. After stacking, the multiple rubber spheres arranged below will collide with each other under the action of inertia force. After the collision, the inner wall will be subjected to vibration force, and the vibration generated will achieve filling, thus solving the trouble and labor intensity of manual operation in the prior art, improving the filling efficiency, and at the same time not requiring additional vibration devices around, solving the problem of complex structure.

[0016] 2. After the Y-axis mechanism operates, the guiding rotating cylinder will rotate. The rotational movement will carry the filler entering inside. The filler will be conveyed downward along the rotational trajectory, providing a certain conveying movement and extrusion effect for the conveying. After the guiding rotating cylinder rotates, it will drive the outer lifting column outside to generate a lifting movement. The outer lifting column will drive the metering plate mechanism connected below to move up and down. After the metering plate mechanism hits the outer rotating cylinder downward, the outer rotating cylinder will generate a vibration force. After the outer rotating cylinder receives the vibration force, the remaining force generated will affect the inner wall of the chromatographic column body, thereby improving the filling effect.

[0017] 3. A number of metering holes provided on the metering plate and the metering bottom plate are correspondingly arranged. When the filler falling from above enters the metering holes, under the influence of the metering holes, the filler will be squeezed inside. In this way, the amount of filler falling downward can be controlled. When the outer lifting column moves up and down, it will drive the metering plate mechanism to continuously hit the stacking mechanism below. Under the impact movement and the vibration hammering force generated, the filler restricted in the metering holes will fall downward, providing a buffering and vibrating effect for the falling material.

[0018] 4. Driven by the guiding rotating cylinder, the stacking mechanism drives the outer rotating cylinder to rotate. The outer rotating cylinder will drive the inner lifting column inside to achieve a lifting movement, and then the inner lifting column will hit the cavity column below. The cavity column is subjected to a vibration force, and the rubber spheres below will collide with each other, continuously hammering the inner wall of the chromatographic column.

[0019] 5. The chromatographic column here is a C18 chromatographic column, and the C18 chromatographic column is a material used in the kit for FDG synthesis. Description of the Drawings

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the accompanying drawings required for use in the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other accompanying drawings can be obtained based on these drawings.

[0021] Figure 1 is the overall structural schematic diagram according to the embodiment of the present invention;

[0022] Figure 2 is the overall sectional view according to the embodiment of the present invention;

[0023] Figure 3 is the structural schematic diagram of the connection between the outer lifting column and the stacking mechanism according to the embodiment of the present invention;

[0024] Figure 4 is the structural schematic diagram of the Y-axis mechanism according to the embodiment of the present invention;

[0025] Figure 5 is the structural schematic diagram of the guiding rotating cylinder according to the embodiment of the present invention;

[0026] Figure 6 is the exploded view of the connection between the Y-axis mechanism and the stacking mechanism according to the embodiment of the present invention;

[0027] Figure 7 is the structural schematic diagram of the inner lifting column according to the embodiment of the present invention;

[0028] Figure 8 is the structural schematic diagram of the outer rotating cylinder according to the embodiment of the present invention;

[0029] Figure 9 is the unfolded structural schematic diagram of the outer rotating cylinder according to the embodiment of the present invention.

[0030] In the figure:

[0031] 1. Chromatographic column body; 2. Bracket seat; 3. Feeding end; 4. Discharging end; 5. Power mechanism; 6. Y-axis mechanism; 7. Metering plate mechanism; 8. Stacking mechanism; 9. Upper connecting column; 10. Guiding rotating cylinder; 11. First guiding groove; 12. Bottom connecting cylinder; 13. Outer lifting column; 14. Limiting rod; 15. Lower connecting column; 16. First buffer block; 17. Second buffer block; 18. Third buffer block; 19. Rotating end block; 20. Inner wall teeth; 21. Outer gear sleeve; 22. Inner sliding groove; 23. Slide block; 24. Baffle plate; 25. Metering bottom plate; 26. Metering plate; 27. Metering hole; 28. Outer rotating cylinder; 29. First hollow plate; 30. Inner lifting column; 31. Second hollow plate; 32. Return spring; 33. Limiting column; 34. Second guiding groove; 35. Cavity column; 36. Discharging hole; 37. Rope; 38. Rubber sphere. Detailed implementation mode

[0032] In order to more clearly understand the above objects, features, and advantages of the present invention, the present invention will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, without conflict, the embodiments of the present application and the features in the embodiments can be combined with each other.

[0033] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0034] According to an embodiment of the present invention, as shown in Figures 1-9 shown:

[0035] The present invention provides a chromatographic column filling device, including a chromatographic column body 1 and a support seat 2. The top of the chromatographic column body 1 is provided with a feed end 3, the bottom of the chromatographic column body 1 is provided with a discharge end 4, and a valve is provided on the discharge end 4; a power mechanism 5, a Y-axis mechanism 6, a metering plate mechanism 7, and a stacking mechanism 8 are provided inside the chromatographic column body 1; the power mechanism 5 is connected to the Y-axis mechanism 6, the Y-axis mechanism 6 is connected to the stacking mechanism 8, and the metering plate mechanism 7 is arranged on the Y-axis mechanism 6; the Y-axis mechanism 6 includes an upper connecting column 9, the upper connecting column 9 is connected to the power mechanism 5, a guiding rotating cylinder 10 is provided at the bottom of the upper connecting column 9, a first guiding groove 11 is provided on the upper part of the surface of the guiding rotating cylinder 10, a bottom connecting cylinder 12 is provided at the bottom of the guiding rotating cylinder 10, an outer lifting column 13 is provided outside the guiding rotating cylinder 10, limiting rods 14 are provided on both corresponding sides of the upper part of the outer lifting column 13, the inner ends of the limiting rods 14 are located in the first guiding groove 11, a lower connecting column 15 is provided at the bottom of the outer lifting column 13, the lower connecting column 15 is connected to the metering plate mechanism 7, the bottom connecting cylinder 12 penetrates through the lower connecting column 15, and the bottom connecting cylinder 12 is connected to the stacking mechanism 8.

[0036] Among them, a first buffer block 16 is provided on the chromatographic column body 1, a second buffer block 17 is provided at the bottom of the first buffer block 16 on the chromatographic column body 1, a third buffer block 18 is provided at the lower part of the chromatographic column body 1, the support seat 2 is fixed on the third buffer block 18, the power mechanism 5 is arranged at the feed end 3, the power mechanism 5 includes a rotating end block 19, the rotating end block 19 is embedded in the inner wall of the first buffer block 16, an inner wall gear 20 is provided inside the rotating end block 19, an outer gear sleeve 21 meshing with the inner wall gear 20 is sleeved on the upper part of the upper connecting column 9, inner sliding grooves 22 are provided on the inner wall of the second buffer block 17, cooperating sliders 23 are provided on both corresponding sides in the inner sliding grooves 22, the sides of the sliders 23 away from the inner sliding grooves 22 are respectively fixed on the side edges of the corresponding limiting rods 14, a through connection material falling channel is provided inside the upper connecting column 9, the guiding rotating cylinder 10, and the bottom connecting cylinder 12, and the bottom connecting cylinder 12 penetrates through the metering plate mechanism 7.

[0037] In addition, the metering plate mechanism 7 includes a metering plate 26. A baffle plate 24 is provided on the side of the metering plate 26. A metering bottom plate 25 is provided at the bottom of the baffle plate 24. A number of metering holes 27 are provided on both the metering plate 26 and the metering bottom plate 25. The metering holes 27 are located at the position inside the bottom connection cylinder 12. The laminating mechanism 8 includes an outer rotating cylinder 28. A hollow plate one 29 is provided at the top of the outer rotating cylinder 28. The top of the hollow plate one 29 is connected to the bottom of the bottom connection cylinder 12. An inner lifting column 30 is provided inside the outer rotating cylinder 28. A hollow plate two 31 is provided at the top of the inner lifting column 30. A return spring 32 is provided at the center of the top of the hollow plate two 31. The top of the return spring 32 is fixed at the center of the bottom of the hollow plate one 29. A number of limiting columns 33 are provided on the upper part of the surface of the inner lifting column 30. A guiding groove two 34 matched with the limiting columns 33 is provided on the inner wall of the outer rotating cylinder 28. A cavity column 35 is provided in the lower inner part of the third buffer block 18. A number of discharge holes 36 are provided at both the top and the bottom of the cavity column 35. The lower discharge holes 36 correspond to the upper discharge holes 36. A number of ropes 37 are provided at the bottom of the cavity column 35. A rubber sphere 38 is provided at the bottom of the ropes 37.

[0038] The cavity column 35 is arranged in the lower inner part of the third buffer block 18. The outer rotating cylinder 28 is located above the third buffer block 18. The top of the outer rotating cylinder 28 is connected to the bottom of the bottom connection cylinder 12. The top of the bottom connection cylinder 12 is connected to the bottom of the guiding rotating cylinder 10. An outer gear sleeve 21 is sleeved on the upper part of the guiding rotating cylinder 10. The outer gear sleeve 21 is connected to the power mechanism 5. The driving of the power mechanism 5 can be realized by arranging an outer gear on the outer side of the rotating end block 19, a meshing gear on the side of the outer gear, and the driving shaft of the gear can be connected with a driver. Then the driver is connected to the chromatographic column body 1 through a bracket. It can also directly rotate the rotating end block 19 by means of an external force. After the rotating end block 19 rotates, it will drive the inner outer gear sleeve 21 inside, and further drive the outer rotating cylinder 28 to rotate.

[0039] A certain distance is left between the metering plate 26 and the metering bottom plate 25. A baffle plate 24 is provided on the sides of the metering plate 26 and the metering bottom plate 25, so as to form a cavity inside. The metering holes 27 on the metering plate 26 and the metering holes 27 on the metering bottom plate 25 are corresponding, so that the path of the upper and lower through is in a diameter state. After the filler enters the metering holes 27, there are certain limitations.

[0040] The aperture of the hollow holes on the hollow plate one 29 and the hollow plate two 31 is larger than the aperture of the metering holes 27. The aperture of the discharge holes 36 provided at the top and the bottom of the cavity column 35 is larger than the aperture of the hollow plate one 29 and the hollow plate two 31.

[0041] The detailed usage method and function of this embodiment:

[0042] When the filler enters the upper connecting column 9 from the feeding end 3, it is conveyed downward along the blanking channel formed inside the upper connecting column 9, the guiding rotating cylinder 10, and the bottom connecting cylinder 12. During the conveying process, the driving rotating end block 19 is driven. When the rotating end block 19 rotates, the inner wall gear teeth 20 on the inner wall of the rotating end block 19 drive the meshing external gear tooth sleeve 21. After the external gear tooth sleeve 21 rotates, it drives the upper connecting column 9 inserted in the middle. The upper connecting column 9 drives the guiding rotating cylinder 10 connected at the bottom. After the guiding rotating cylinder 10 rotates, the guiding groove 11 on the upper side will drive the internally engaged limiting rod 14, and the limiting rod 14 will slide along the track of the guiding groove 11, thereby promoting the up and down movement of the outer lifting column 13. When the guiding rotating cylinder 10 rotates, the internally flowing filler will generate a centrifugal movement along with the rotation, increasing the blanking speed, and bringing up the filler into the lower metering hole 27. Under the influence of the metering hole 27, the metering effect is achieved. When the outer lifting column 13 moves up and down, it presses the metering plate mechanism 7 downward together. The metering plate mechanism 7 impacts the first hollow plate 29. After the metering plate 26 and the metering bottom plate 25 are vibrated, the filler in the metering hole 27 will be filled downward under the action of vibration. At the same time, when the guiding rotating cylinder 10 rotates, it drives the bottom connecting cylinder 12 connected at the bottom to rotate together. After the bottom connecting cylinder 12 rotates, the guiding groove 34 on the inner wall will drive the limiting column 33 sliding inside. The limiting column 33 moves up and down along the track of the guiding groove 34. At this time, the inner lifting column 30 will move up and down inside the outer rotating cylinder 28. After the inner lifting column 30 moves up and down, it will continuously impact the cavity column 35. After the cavity column 35 is impacted up and down, the rubber spheres 38 connected at the bottom will impact each other and continuously knock on the inner wall of the chromatographic column body 1. After the inner wall is knocked, the filler falling inside will be compacted under the vibration and knocking.

[0043] Through the above specific embodiments, those skilled in the art of the present invention can easily implement the present invention. However, it should be understood that the present invention is not limited to the above specific embodiments. Based on the disclosed embodiments, those skilled in the art can arbitrarily combine different technical features to achieve different technical solutions.

Claims

1. A chromatographic column filling device, characterized in that, It includes a chromatographic column body (1) and a support base (2). The top of the chromatographic column body (1) is provided with a feeding end (3), the bottom of the chromatographic column body (1) is provided with a discharging end (4), and a valve is provided on the discharging end (4). A power mechanism (5), a Y-axis mechanism (6), a metering plate mechanism (7) and a stacking mechanism (8) are arranged inside the chromatographic column body (1). The power mechanism (5) is connected to the Y-axis mechanism (6), the Y-axis mechanism (6) is connected to the stacking mechanism (8), and the metering plate mechanism (7) is arranged on the Y-axis mechanism (6). The Y-axis mechanism (6) includes an upper connecting column (9). The upper connecting column (9) is connected to the power mechanism (5). The bottom of the upper connecting column (9) is provided with a guiding rotating cylinder (10). The upper part of the surface of the guiding rotating cylinder (10) is provided with a first guiding groove (11). The bottom of the guiding rotating cylinder (10) is provided with a bottom connecting cylinder (12). An outer lifting column (13) is arranged outside the guiding rotating cylinder (10). Limiting rods (14) are arranged on both corresponding sides of the upper part of the outer lifting column (13). The inner ends of the limiting rods (14) are located in the first guiding groove (11). The bottom of the outer lifting column (13) is provided with a lower connecting column (15). The lower connecting column (15) is connected to the metering plate mechanism (7). The bottom connecting cylinder (12) penetrates through the lower connecting column (15), and the bottom connecting cylinder (12) is connected to the stacking mechanism (8).

2. The chromatographic column packing device according to claim 1, wherein A first buffer block (16) is arranged on the chromatographic column body (1). A second buffer block (17) is arranged at the bottom of the first buffer block (16) on the chromatographic column body (1). A third buffer block (18) is arranged at the lower part of the chromatographic column body (1). The support base (2) is fixed on the third buffer block (18).

3. The chromatographic column filling device according to claim 2, wherein The power mechanism (5) is arranged at the feeding end (3). The power mechanism (5) includes a rotating end block (19). The rotating end block (19) is embedded in the inner wall of the first buffer block (16). Inner wall teeth (20) are arranged inside the rotating end block (19). An outer gear sleeve (21) meshing with the inner wall teeth (20) is sleeved on the upper part of the upper connecting column (9).

4. A chromatographic column filling device according to claim 2, characterized in that, Inner sliding grooves (22) are arranged on the inner wall of the second buffer block (17). Sliding blocks (23) are arranged on both corresponding sides inside the inner sliding grooves (22). The sides of the sliding blocks (23) far away from the inner sliding grooves (22) are respectively fixed on the side edges of the corresponding limiting rods (14).

5. The chromatographic column filling device according to claim 1, characterized in that A through connection blanking channel is arranged inside the upper connecting column (9), the guiding rotating cylinder (10) and the bottom connecting cylinder (12). The bottom connecting cylinder (12) penetrates through the metering plate mechanism (7).

6. The chromatographic column filling device according to claim 1, wherein, The metering plate mechanism (7) includes a metering plate (26). A baffle plate (24) is arranged on the side of the metering plate (26). A metering bottom plate (25) is arranged at the bottom of the baffle plate (24). A plurality of metering holes (27) are arranged on both the metering plate (26) and the metering bottom plate (25). The metering holes (27) are located at the position inside the bottom connecting cylinder (12).

7. A chromatographic column filling device according to claim 2, characterized in that, The laminated mechanism (8) includes an outer rotating cylinder (28). A first hollow plate (29) is provided at the top of the outer rotating cylinder (28). The top of the first hollow plate (29) is connected to the bottom of the bottom connecting cylinder (12). An inner lifting column (30) is provided inside the outer rotating cylinder (28). A second hollow plate (31) is provided at the top of the inner lifting column (30). A return spring (32) is provided at the center of the top of the second hollow plate (31). The top of the return spring (32) is fixed at the center of the bottom of the first hollow plate (29). A number of limiting columns (33) are provided on the upper part of the surface of the inner lifting column (30). A second guiding groove (34) that mates with the limiting columns (33) is provided on the inner wall of the outer rotating cylinder (28).

8. A chromatographic column filling device according to claim 7, characterized in that, A cavity column (35) is provided in the lower inner part of the third buffer block (18). A number of discharge holes (36) are provided at the top and bottom of the cavity column (35). The lower discharge holes (36) correspond to the upper discharge holes (36). A number of ropes (37) are provided at the bottom of the cavity column (35). A rubber sphere (38) is provided at the bottom of the ropes (37).

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